title: Platinum(II) complexes containing ferrocene-derived phosphonate ligands; synthesis, structural characterisation and antitumour activity

authors: Henderson, William

subjects: chemistry

abstract: Platinum ferrocenyl–phosphonate complexes, containing four-membered Pt---O---P(O)---O rings, have been synthesised by the reactions of cis-[PtCl₂(PPh₃)₂] with the ferrocene-derived phosphonic acids Fc(CH₂)nP(O)(OH)₂(n=0–2) [Fc=(η⁵-C₅H₄)Fe(η⁵-C₅H₅)] and 1,1′-Fc′[P(O)(OH)₂]₂ [Fc′=Fe(η⁵-C₅H₄)₂] in the presence of Ag₂O. The complexes have been characterised by NMR spectroscopy, together with crystal structure determinations on [Fc(CH₂)nPO₃Pt(PPh₃)₂] (n=1, 2) and [1,1′-Fc′{PO₃Pt(PPh₃)₂}₂]. The complexes [Fc(CH₂)nPO₃Pt(PPh₃)₂] (n=1, 2) show moderate activity against P388 leukaemia cells, whereas the parent phosphonic acids are inactive.

text: Platinum(II) complexes containing ferrocene-derived phosphonate ligands; synthesis, structural characterisation and antitumour activity Platinum ferrocenyl–phosphonate complexes, containing four-membered Pt---O---P(O)---O rings, have been synthesised by the reactions of cis-[PtCl₂(PPh₃)₂] with the ferrocene-derived phosphonic acids Fc(CH₂)nP(O)(OH)₂(n=0–2) [Fc=(η⁵-C₅H₄)Fe(η⁵-C₅H₅)] and 1,1′-Fc′[P(O)(OH)₂]₂ [Fc′=Fe(η⁵-C₅H₄)₂] in the presence of Ag₂O. The complexes have been characterised by NMR spectroscopy, together with crystal structure determinations on [Fc(CH₂)nPO₃Pt(PPh₃)₂] (n=1, 2) and [1,1′-Fc′{PO₃Pt(PPh₃)₂}₂]. The complexes [Fc(CH₂)nPO₃Pt(PPh₃)₂] (n=1, 2) show moderate activity against P388 leukaemia cells, whereas the parent phosphonic acids are inactive.

year: 2001

title: A Toolbox for Learning from Relational Data with Propositional and Multi-instance Learners

authors: Reutemann, Peter

subjects: Computer science

abstract: Most databases employ the relational model for data storage. To use this data in a propositional learner, a propositionalization step has to take place. Similarly, the data has to be transformed to be amenable to a multi-instance learner. The Proper Toolbox contains an extended version of RELAGGS, the Multi-Instance Learning Kit MILK, and can also combine the multi-instance data with aggregated data from RELAGGS. RELAGGS was extended to handle arbitrarily nested relations and to work with both primary keys and indices. For MILK the relational model is flattened into a single table and this data is fed into a multi-instance learner. REMILK finally combines the aggregated data produced by RELAGGS and the multi-instance data, flattened for MILK, into a single table that is once again the input for a multi-instance learner. Several well-known datasets are used for experiments which highlight the strengths and weaknesses of the different approaches.

text: A Toolbox for Learning from Relational Data with Propositional and Multi-instance Learners Most databases employ the relational model for data storage. To use this data in a propositional learner, a propositionalization step has to take place. Similarly, the data has to be transformed to be amenable to a multi-instance learner. The Proper Toolbox contains an extended version of RELAGGS, the Multi-Instance Learning Kit MILK, and can also combine the multi-instance data with aggregated data from RELAGGS. RELAGGS was extended to handle arbitrarily nested relations and to work with both primary keys and indices. For MILK the relational model is flattened into a single table and this data is fed into a multi-instance learner. REMILK finally combines the aggregated data produced by RELAGGS and the multi-instance data, flattened for MILK, into a single table that is once again the input for a multi-instance learner. Several well-known datasets are used for experiments which highlight the strengths and weaknesses of the different approaches.

year: 2005

title: Taku haumaru me te kurī: He aratohu mō te haumaru i waenga i te tamariki (8-9 pea ngā tau) me te kurī - Te Reo Maori

authors: Carter, Jennifer

subjects: dog safety tips

abstract: This safety booklet for older children (about 8-9yrs) will provide the best level of understanding of how to avoid pet dog attacks which can injure, maim and even kill children. This research-based educational resource provides practical, valid and reliable guidelines for safe interaction between children and pet dogs in their homes or known to them. The content of this booklet has been drawn from ‘Stories with happy endings: Preventing pet dog attacks on children’, the 2007-2008 Summer Scholarship report prepared for the Child Accident Prevention Foundation of New Zealand (CAPFNZ). Obtain a copy of the report from http://hdl.handle.net/10289/768

text: Taku haumaru me te kurī: He aratohu mō te haumaru i waenga i te tamariki (8-9 pea ngā tau) me te kurī - Te Reo Maori This safety booklet for older children (about 8-9yrs) will provide the best level of understanding of how to avoid pet dog attacks which can injure, maim and even kill children. This research-based educational resource provides practical, valid and reliable guidelines for safe interaction between children and pet dogs in their homes or known to them. The content of this booklet has been drawn from ‘Stories with happy endings: Preventing pet dog attacks on children’, the 2007-2008 Summer Scholarship report prepared for the Child Accident Prevention Foundation of New Zealand (CAPFNZ). Obtain a copy of the report from http://hdl.handle.net/10289/768

year: 2008