title: Tricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: structures, solution behavior and cytotoxicity

authors: Zhang, Jianyong

subjects: chemistry

abstract: Modified Mannich reactions of amines, amino acids and a model peptide with Ph₂PH and CH₂O gave bis(diphenylphosphinomethyl)amines (Ph₂PCH₂)₂NR [R=Ph (1), CH₂CH₂OH (2), CH₂COOCH₂Ph (3), CH₂CONHCH₂COOCH₂Ph (4), CH2COOH (5)] and (Ph₂PCH₂)₂NCH₂CH₂N(CH₂PPh₂)₂ (6). Reaction with [ReBr₃(CO)₃]²⁻ under mild conditions led to [ReBr(CO)₃]{(Ph₂PCH₂)₂NR} [R=Ph (7), CH₂CH₂OH (8), CH₂COOCH₂Ph (9), CH₂CONHCH₂COOCH₂Ph (10), CH₂COOH (11)] and [ReBr(CO)₃(Ph₂PCH₂)₂NCH₂]₂ (12). All new complexes have been characterized by NMR and IR spectroscopy and for 7, 9 and 10, single-crystal X-ray diffraction analyses. Electrospray mass spectrometric studies show that the rhenium–phosphine chelates are very stable, especially in neutral methanolic solution. Hydrolysis of the ester and amide linkages slowly occur in acidic and basic solutions over several weeks; displacement of the bromide ligand also occurs in basic medium. Cytotoxicity testing of 7–10 and 12 showed that all the complexes are active against specific tumor cell lines, especially MCF-7 breast cancer and HeLa-S3 suspended uterine carcinoma.

text: Tricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: structures, solution behavior and cytotoxicity Modified Mannich reactions of amines, amino acids and a model peptide with Ph₂PH and CH₂O gave bis(diphenylphosphinomethyl)amines (Ph₂PCH₂)₂NR [R=Ph (1), CH₂CH₂OH (2), CH₂COOCH₂Ph (3), CH₂CONHCH₂COOCH₂Ph (4), CH2COOH (5)] and (Ph₂PCH₂)₂NCH₂CH₂N(CH₂PPh₂)₂ (6). Reaction with [ReBr₃(CO)₃]²⁻ under mild conditions led to [ReBr(CO)₃]{(Ph₂PCH₂)₂NR} [R=Ph (7), CH₂CH₂OH (8), CH₂COOCH₂Ph (9), CH₂CONHCH₂COOCH₂Ph (10), CH₂COOH (11)] and [ReBr(CO)₃(Ph₂PCH₂)₂NCH₂]₂ (12). All new complexes have been characterized by NMR and IR spectroscopy and for 7, 9 and 10, single-crystal X-ray diffraction analyses. Electrospray mass spectrometric studies show that the rhenium–phosphine chelates are very stable, especially in neutral methanolic solution. Hydrolysis of the ester and amide linkages slowly occur in acidic and basic solutions over several weeks; displacement of the bromide ligand also occurs in basic medium. Cytotoxicity testing of 7–10 and 12 showed that all the complexes are active against specific tumor cell lines, especially MCF-7 breast cancer and HeLa-S3 suspended uterine carcinoma.

year: 2002

title: The Global Lake Ecological Observatory Network (GLEON): the evolution of grassroots network science

authors: Weathers, Kathleen

abstract: Nine years later, with over 380 members from 40 countries, and 50 publications to its credit, GLEON is growing at a rapid pace and pushing the boundaries of the practice of network science. GLEON is really three networks: a network of lakes, data, and people

text: The Global Lake Ecological Observatory Network (GLEON): the evolution of grassroots network science Nine years later, with over 380 members from 40 countries, and 50 publications to its credit, GLEON is growing at a rapid pace and pushing the boundaries of the practice of network science. GLEON is really three networks: a network of lakes, data, and people

year: 2013

title: The Role of Fatherhood in the Everyday Life of Young Māori Men

authors: Elkington, Angus Marangai Brons

subjects: maori men

abstract: Little research exists that explores the positive aspects of young Māori fathers. The aim of this study was to explore the everyday lived reality of expectant and young Māori males as fathers and partners, within the context of a positive based approach and Kaupapa Māori research framework. A secondary objective of this study was to provide ideas to enhance parent resources for young Māori fathers, such as father centric parenting programmes and mobile applications. The research was derived from semi-structured interviews, which explored the unique experiences and narratives of eight young Māori fathers between the age of 16 and 25 years of age. Using thematic analysis, the findings were categorised into key themes that portrayed their perception and attitudes to roles, responsibility, relationships, barriers, and wellbeing strategies. The findings identified, a strong desire of young Māori fathers to be involved with their children and that the quality of whānau relationships provided resilience, support, and motivation to fulfil the responsibilities of fatherhood. The young Māori fathers had strong goals and aspirations but acknowledged barriers that delayed their ability to achieve them. In the outcome of this study, I have tried to portray a positive understanding of young Māori fathers and to challenge the negative stereotypes that persist in New Zealand society. Furthermore, this research supports the need for restorative cultural practices as the key to wellbeing for our whānau and further investigations in regards to policy reforms and resources to include full participation in society.

text: The Role of Fatherhood in the Everyday Life of Young Māori Men Little research exists that explores the positive aspects of young Māori fathers. The aim of this study was to explore the everyday lived reality of expectant and young Māori males as fathers and partners, within the context of a positive based approach and Kaupapa Māori research framework. A secondary objective of this study was to provide ideas to enhance parent resources for young Māori fathers, such as father centric parenting programmes and mobile applications. The research was derived from semi-structured interviews, which explored the unique experiences and narratives of eight young Māori fathers between the age of 16 and 25 years of age. Using thematic analysis, the findings were categorised into key themes that portrayed their perception and attitudes to roles, responsibility, relationships, barriers, and wellbeing strategies. The findings identified, a strong desire of young Māori fathers to be involved with their children and that the quality of whānau relationships provided resilience, support, and motivation to fulfil the responsibilities of fatherhood. The young Māori fathers had strong goals and aspirations but acknowledged barriers that delayed their ability to achieve them. In the outcome of this study, I have tried to portray a positive understanding of young Māori fathers and to challenge the negative stereotypes that persist in New Zealand society. Furthermore, this research supports the need for restorative cultural practices as the key to wellbeing for our whānau and further investigations in regards to policy reforms and resources to include full participation in society.

year: 2016