title: Top ten priorities for future infertility research

authors: Duffy, James M. N.

abstract: Introduction: Despite the escalation in research activity and an exponential rise in published papers, many of the fundamental questions about the treatment of infertility remain. This is a barrier to improving the care people with infertility receive.
Objective: To identify and prioritise important research questions for infertility.
Methods: An international Priority Setting Partnership was established, including healthcare professionals, researchers, and people with infertility. Research uncertainties were gathered from healthcare professionals, researchers, and people with infertility. These research uncertainties were prioritised in a transparent process, using robust consensus science methods advocated by the James Lind Alliance (1).
Results: In the initial survey, 179 healthcare professionals, 28 researchers, and 153 people with infertility, submitted 423 research uncertainties. A review of clinical practice guidelines and Cochrane systematic reviews identified a further 236 research uncertainties. A long list of 231 research questions was entered into an interim prioritisation survey which was completed by 103 healthcare professionals, 28 researchers, and 169 people with infertility. Prioritised research uncertainties were entered into a consensus development conference. Using the modified Nominal Group Technique, 17 healthcare professionals, seven researchers, and 14 people with infertility prioritised the top ten research uncertainties for infertility.
Conclusions: We anticipate a prioritised list of research uncertainties, developed to specifically highlight the most pressing clinical needs as perceived by people with infertility and healthcare professionals working in the field, will help funding organisations and researchers to set their future research priorities. We are drowning in research that is singularly lacking in impact. Our approach should ensure future research has the necessary reach and relevance to inform future clinical practice and improve patient outcomes.

text: Top ten priorities for future infertility research Introduction: Despite the escalation in research activity and an exponential rise in published papers, many of the fundamental questions about the treatment of infertility remain. This is a barrier to improving the care people with infertility receive.
Objective: To identify and prioritise important research questions for infertility.
Methods: An international Priority Setting Partnership was established, including healthcare professionals, researchers, and people with infertility. Research uncertainties were gathered from healthcare professionals, researchers, and people with infertility. These research uncertainties were prioritised in a transparent process, using robust consensus science methods advocated by the James Lind Alliance (1).
Results: In the initial survey, 179 healthcare professionals, 28 researchers, and 153 people with infertility, submitted 423 research uncertainties. A review of clinical practice guidelines and Cochrane systematic reviews identified a further 236 research uncertainties. A long list of 231 research questions was entered into an interim prioritisation survey which was completed by 103 healthcare professionals, 28 researchers, and 169 people with infertility. Prioritised research uncertainties were entered into a consensus development conference. Using the modified Nominal Group Technique, 17 healthcare professionals, seven researchers, and 14 people with infertility prioritised the top ten research uncertainties for infertility.
Conclusions: We anticipate a prioritised list of research uncertainties, developed to specifically highlight the most pressing clinical needs as perceived by people with infertility and healthcare professionals working in the field, will help funding organisations and researchers to set their future research priorities. We are drowning in research that is singularly lacking in impact. Our approach should ensure future research has the necessary reach and relevance to inform future clinical practice and improve patient outcomes.

year: 2020-01-09

title: Real time NMR analyses of phenolic resin reactions

authors: Woolley, Samuel Lindsay

subjects: Phenolic

abstract: The current investigation presents the development and application of a  Rapid  NMR acquisition method, capable of identifying transient species and quantitatively monitoring their changes in real time during an in situ phenolic resin preparation. This quantification was only possible after the determination of phenolic resin relaxation times (T1) and nuclear Overhauser enhancements (NOE).

Rapid NMR spectra were recorded with an inter-pulse delay time of 0.6 s and broadband decoupling, which resulted in the acquisition of sequential qualitative spectra at 2.5 min intervals. The obtained qualitative spectral data were then converted into quantitative spectral data via the derived cross calibration (fc) and NOE (η) factors, resulting in quantitative reaction profiles for the phenoic resin species under investigation.

Extension of this work will allow the effects of varying synthesis parameters (i.e. temperature, pH, stoichiometry, catalyst type, etc.) on the final structure and hence on the final physical properties of the resin to be determined and inevitably leading to the development of new, more innovative and cost-effective resins.

text: Real time NMR analyses of phenolic resin reactions The current investigation presents the development and application of a  Rapid  NMR acquisition method, capable of identifying transient species and quantitatively monitoring their changes in real time during an in situ phenolic resin preparation. This quantification was only possible after the determination of phenolic resin relaxation times (T1) and nuclear Overhauser enhancements (NOE).

Rapid NMR spectra were recorded with an inter-pulse delay time of 0.6 s and broadband decoupling, which resulted in the acquisition of sequential qualitative spectra at 2.5 min intervals. The obtained qualitative spectral data were then converted into quantitative spectral data via the derived cross calibration (fc) and NOE (η) factors, resulting in quantitative reaction profiles for the phenoic resin species under investigation.

Extension of this work will allow the effects of varying synthesis parameters (i.e. temperature, pH, stoichiometry, catalyst type, etc.) on the final structure and hence on the final physical properties of the resin to be determined and inevitably leading to the development of new, more innovative and cost-effective resins.

year: 2008

title: Editorial: Special Issue: Ignored no longer: Emerging Indigenous researchers on Indigenous psychologies

authors: Groot, Shiloh Ann Maree

abstract: In this special issue, edited by Mohi, Bridgette, Shiloh, Pat and Darren, we showcase work conducted within several such Indigenous psychologies. This collection of papers from emerging Indigenous scholars reflect a vibrant, healthy and supportive research environment in which conversations relevant to Indigenous peoples are taking place, and where culturally diverse perspectives and methods are valued and accepted. Here, culture is not simply seen as an abstract set of concepts. Culture constitutes a field of human action, meaning making, and self-production. It is through culture that all people construct themselves and make sense of the world (Groot, Hodgetts, Nikora, & Leggat-Cook, 2011; Nikora, Rua, & Te Awekōtuku, 2007).

text: Editorial: Special Issue: Ignored no longer: Emerging Indigenous researchers on Indigenous psychologies In this special issue, edited by Mohi, Bridgette, Shiloh, Pat and Darren, we showcase work conducted within several such Indigenous psychologies. This collection of papers from emerging Indigenous scholars reflect a vibrant, healthy and supportive research environment in which conversations relevant to Indigenous peoples are taking place, and where culturally diverse perspectives and methods are valued and accepted. Here, culture is not simply seen as an abstract set of concepts. Culture constitutes a field of human action, meaning making, and self-production. It is through culture that all people construct themselves and make sense of the world (Groot, Hodgetts, Nikora, & Leggat-Cook, 2011; Nikora, Rua, & Te Awekōtuku, 2007).

year: 2012