title: Treatment and survival disparities by ethnicity in New Zealand women with stage I-III breast cancer tumour subtypes

authors: Lawrenson, Ross

subjects: Science & Technology

abstract: Purpose
This study aims to look at the distribution of different subtypes of stage I–III breast cancer in Māori and Pacific versus non-Māori/Pacific women, and to examine cancer outcomes by ethnicity within these different subtypes.

Method
This study included 9,015 women diagnosed with stage I–III breast cancer between June 2000 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, who had complete data on ER, PR and HER2 status. Five ER/PR/HER2 subtypes were defined. Kaplan–Meier method and Cox proportional hazards model were used to examine ethnic disparities in breast cancer-specific survival.

Results
Of the 9,015 women, 891 were Māori, 548 were Pacific and 7,576 others. Both Māori and Pacific women were less likely to have triple negative breast cancer compared to others (8.6, 8.9 vs. 13.0%). Pacific women were more than twice as likely to have ER−, PR− and HER2+ cancer than Māori and others (14.2 vs. 6.0%, 6.7%). After adjustment for age, year of diagnosis, stage, grade and treatment, the hazard ratios of breast cancer-specific mortality for Māori and Pacific women with ER+, PR+ and HER2− were 1.52 (95% CI 1.06–2.18) and 1.55 (95% CI 1.04–2.31) compared to others, respectively. Māori women with HER2+ cancer were twice more likely to die of their cancer than others.

Conclusions
Outcomes for Māori and Pacific women could be improved by better treatment regimens especially for those with HER2+ breast cancer and for women with ER+, PR+ and HER2− breast cancer.

text: Treatment and survival disparities by ethnicity in New Zealand women with stage I-III breast cancer tumour subtypes Purpose
This study aims to look at the distribution of different subtypes of stage I–III breast cancer in Māori and Pacific versus non-Māori/Pacific women, and to examine cancer outcomes by ethnicity within these different subtypes.

Method
This study included 9,015 women diagnosed with stage I–III breast cancer between June 2000 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, who had complete data on ER, PR and HER2 status. Five ER/PR/HER2 subtypes were defined. Kaplan–Meier method and Cox proportional hazards model were used to examine ethnic disparities in breast cancer-specific survival.

Results
Of the 9,015 women, 891 were Māori, 548 were Pacific and 7,576 others. Both Māori and Pacific women were less likely to have triple negative breast cancer compared to others (8.6, 8.9 vs. 13.0%). Pacific women were more than twice as likely to have ER−, PR− and HER2+ cancer than Māori and others (14.2 vs. 6.0%, 6.7%). After adjustment for age, year of diagnosis, stage, grade and treatment, the hazard ratios of breast cancer-specific mortality for Māori and Pacific women with ER+, PR+ and HER2− were 1.52 (95% CI 1.06–2.18) and 1.55 (95% CI 1.04–2.31) compared to others, respectively. Māori women with HER2+ cancer were twice more likely to die of their cancer than others.

Conclusions
Outcomes for Māori and Pacific women could be improved by better treatment regimens especially for those with HER2+ breast cancer and for women with ER+, PR+ and HER2− breast cancer.

year: 2017

title: Te Mauri o te Kaitiaki - Exploring Te Ao Māori in environmental relations and kaitiakitanga  in Aotearoa New Zealand

authors: Wareka, Mona-Lisa

subjects: Te Ao Māori

abstract: Indigenous environmental empowerment is on the rise as humans look at ways to slow the adverse effects of anthropogenic environmental degradation. In the context of Aotearoa New Zealand, the concept and practice of ‘kaitiaki’ and ‘kaitiakitanga’, respectfully, play a significant role in the co-existence of Māori with the natural world. Previous research shows the innate connections and responsibilities encompassed in being kaitiaki which extend beyond the human element to encompass nonhumans and spiritual manifestations. This research aims to illustrate how Māori use cultural values, concepts and practices in local-level conservational practices through ethnographic research in Matapōuri. I investigate the conflicts and convergences of a rāhui recently placed on two cultural significant areas to the local hapū, and through this, I analyse the practical and spiritual application of kaitiakitanga. Based on this ethnography, I discuss a model for relating environmental degradation with the wellbeing of Māori within Aotearoa New Zealand today. Here, I wish to highlight the ecological and cultural threats present from continuing in the current system. Lastly, I argue that the assertion of kaitiakitanga at the local-level is also an assertion of Indigenous autonomy for Māori and the environment.

text: Te Mauri o te Kaitiaki - Exploring Te Ao Māori in environmental relations and kaitiakitanga  in Aotearoa New Zealand Indigenous environmental empowerment is on the rise as humans look at ways to slow the adverse effects of anthropogenic environmental degradation. In the context of Aotearoa New Zealand, the concept and practice of ‘kaitiaki’ and ‘kaitiakitanga’, respectfully, play a significant role in the co-existence of Māori with the natural world. Previous research shows the innate connections and responsibilities encompassed in being kaitiaki which extend beyond the human element to encompass nonhumans and spiritual manifestations. This research aims to illustrate how Māori use cultural values, concepts and practices in local-level conservational practices through ethnographic research in Matapōuri. I investigate the conflicts and convergences of a rāhui recently placed on two cultural significant areas to the local hapū, and through this, I analyse the practical and spiritual application of kaitiakitanga. Based on this ethnography, I discuss a model for relating environmental degradation with the wellbeing of Māori within Aotearoa New Zealand today. Here, I wish to highlight the ecological and cultural threats present from continuing in the current system. Lastly, I argue that the assertion of kaitiakitanga at the local-level is also an assertion of Indigenous autonomy for Māori and the environment.

year: 2020

title: Evolving web-based test automation into agile business specifications

authors: Mugridge, Rick

subjects: web test automation

abstract: Usually, test automation scripts for a web application directly mirror the actions that the tester carries out in the browser, but they tend to be verbose and repetitive, making them expensive to maintain and ineffective in an agile setting. Our research has focussed on providing tool-support for business-level, example-based specifications that are mapped to the browser level for automatic verification. We provide refactoring support for the evolution of existing browser-level tests into business-level specifications. As resulting business rule tables may be incomplete, redundant or contradictory, our tool provides feedback on coverage.

text: Evolving web-based test automation into agile business specifications Usually, test automation scripts for a web application directly mirror the actions that the tester carries out in the browser, but they tend to be verbose and repetitive, making them expensive to maintain and ineffective in an agile setting. Our research has focussed on providing tool-support for business-level, example-based specifications that are mapped to the browser level for automatic verification. We provide refactoring support for the evolution of existing browser-level tests into business-level specifications. As resulting business rule tables may be incomplete, redundant or contradictory, our tool provides feedback on coverage.

year: 2011