title: The role of dynamics in enzyme activity

authors: Daniel, Roy M.

subjects: protein flexibility

abstract: Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or ligand binding may have different dynamical dependencies from those for enzymes, and enzymes with large turnover numbers may have different dynamical dependencies from those that turn over more slowly. The timescale differences between the fastest anharmonic fluctuations and the barrier-crossing rate point to the need to develop methods to resolve the range of motions present in enzymes on different time- and lengthscales.

text: The role of dynamics in enzyme activity Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or ligand binding may have different dynamical dependencies from those for enzymes, and enzymes with large turnover numbers may have different dynamical dependencies from those that turn over more slowly. The timescale differences between the fastest anharmonic fluctuations and the barrier-crossing rate point to the need to develop methods to resolve the range of motions present in enzymes on different time- and lengthscales.

year: 2003

title: Laptops for teachers: An evaluation of the TELA scheme in schools (Years 4 to 6)

authors: Cowie, Bronwen

subjects: Laptop for Teachers Scheme

abstract: The purpose of this evaluation was to investigate the impacts of the Laptops for Teachers Scheme (referred to from here as the TELA scheme) on Years 4 to 6 teachers’ work over a period of three years (2004-2006) and to record emerging changes in laptop use. The investigation focused on the Ministry of Education expectation (Ministry of Education, 2004) that teacher access to a laptop for their individual professional use would lead to gains in confidence and expertise in the use of ICTs, to efficiencies in administration, would contribute to teacher collaboration and support the preparation of high quality lesson resources. It was also anticipated that teacher would use their laptop in the classroom for teaching and learning.

text: Laptops for teachers: An evaluation of the TELA scheme in schools (Years 4 to 6) The purpose of this evaluation was to investigate the impacts of the Laptops for Teachers Scheme (referred to from here as the TELA scheme) on Years 4 to 6 teachers’ work over a period of three years (2004-2006) and to record emerging changes in laptop use. The investigation focused on the Ministry of Education expectation (Ministry of Education, 2004) that teacher access to a laptop for their individual professional use would lead to gains in confidence and expertise in the use of ICTs, to efficiencies in administration, would contribute to teacher collaboration and support the preparation of high quality lesson resources. It was also anticipated that teacher would use their laptop in the classroom for teaching and learning.

year: 2010

title: Blue-lip'd cannibal ladies: The allure of the exotic in the illicit Resolution Journal of Gunner John Marra

authors: Ryan, Tom

subjects: John Marra

abstract: Discusses the history and content of the “Journal of the Resolution’s Voyage”, an unauthorized and illicitly published account of Cook’s second voyage of exploration in the Antipodes, by Gunner John Marra of the Resolution’s crew.

text: Blue-lip'd cannibal ladies: The allure of the exotic in the illicit Resolution Journal of Gunner John Marra Discusses the history and content of the “Journal of the Resolution’s Voyage”, an unauthorized and illicitly published account of Cook’s second voyage of exploration in the Antipodes, by Gunner John Marra of the Resolution’s crew.

year: 2001