title: A bookmaker's workbench

authors: Liesaputra, Veronica

subjects: computer science

abstract: We have been developing electronic Realistic Books that combine the natural advantages of electronic documents---full-text search, hyperlinks, animation, multimedia---with those of conventional books---the ambient information provided by the physical object, analog page turning, random-access navigation, bookmarks, highlighting and annotation. Although simple Realistic Books can easily be created from PDF or HTML files using a shell script or web service, it is not so easy for book designers to take advantage of advanced features that are not normally represented in the input files. This paper describes the Bookmaker's Workbench, an interactive system intended to help book designers produce Realistic Books. It incorporates many features, including a text mining option that automatically identifies significant key terms and marks them visually in the text, the ability to incorporate synonyms automatically into the full-text search capability, and include automatically generated back-of-the-book index. A user evaluation is reported that demonstrates the system's usability and learnability.

text: A bookmaker's workbench We have been developing electronic Realistic Books that combine the natural advantages of electronic documents---full-text search, hyperlinks, animation, multimedia---with those of conventional books---the ambient information provided by the physical object, analog page turning, random-access navigation, bookmarks, highlighting and annotation. Although simple Realistic Books can easily be created from PDF or HTML files using a shell script or web service, it is not so easy for book designers to take advantage of advanced features that are not normally represented in the input files. This paper describes the Bookmaker's Workbench, an interactive system intended to help book designers produce Realistic Books. It incorporates many features, including a text mining option that automatically identifies significant key terms and marks them visually in the text, the ability to incorporate synonyms automatically into the full-text search capability, and include automatically generated back-of-the-book index. A user evaluation is reported that demonstrates the system's usability and learnability.

year: 2011

title: Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure

authors: Fraser-Smith, Emma Louise

subjects: Calpain

abstract: Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that we understand the mechanism of meat tenderisation of which, the calpain protease system is believed to play a central role.
This thesis focuses on three aspects; characterisation of calpain activity, the effect of porcine μ-calpain on myofibril degradation and the effect of μ-calpain on specific proteins desmin and troponin-T.
To study the effect of calpain activity, fluorogenic assays were used to determine: μ-calpain concentration for optimal peptide cleavage; calcium requirements and the effect of chelating substances on the activity of μ-calpain. In addition, the affinity of μ-calpain for substrates CalS-I and CalS-III were assessed.
The effect of μ-calpain on myofibril degradation was evaluated through the use of myofibrillar fragmentation index and density marker beads. Myofibrils were digested at three different temperatures for varying time periods. Conflicting results were displayed and it was concluded that these methods are not accurate, thus further research should be conducted to ensure inconsistencies are eliminated.
Specific proteins desmin and troponin-T have previously been shown to exhibit degradation in the presence of calcium and μ-calpain. SDS-polyacrylamide electrophoresis, western blotting and densitometry measurements were utilized to investigate this effect. It was concluded that μ-calpain plays a significant role in the post mortem proteolysis of myofibrillar protein.
This thesis provides information and strives to give a better understanding of the proteolytic changes that occur within muscle. Understanding how these mechanisms affect meat on a cellular level, can help to control the influence they inflict on meat quality.

text: Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that we understand the mechanism of meat tenderisation of which, the calpain protease system is believed to play a central role.
This thesis focuses on three aspects; characterisation of calpain activity, the effect of porcine μ-calpain on myofibril degradation and the effect of μ-calpain on specific proteins desmin and troponin-T.
To study the effect of calpain activity, fluorogenic assays were used to determine: μ-calpain concentration for optimal peptide cleavage; calcium requirements and the effect of chelating substances on the activity of μ-calpain. In addition, the affinity of μ-calpain for substrates CalS-I and CalS-III were assessed.
The effect of μ-calpain on myofibril degradation was evaluated through the use of myofibrillar fragmentation index and density marker beads. Myofibrils were digested at three different temperatures for varying time periods. Conflicting results were displayed and it was concluded that these methods are not accurate, thus further research should be conducted to ensure inconsistencies are eliminated.
Specific proteins desmin and troponin-T have previously been shown to exhibit degradation in the presence of calcium and μ-calpain. SDS-polyacrylamide electrophoresis, western blotting and densitometry measurements were utilized to investigate this effect. It was concluded that μ-calpain plays a significant role in the post mortem proteolysis of myofibrillar protein.
This thesis provides information and strives to give a better understanding of the proteolytic changes that occur within muscle. Understanding how these mechanisms affect meat on a cellular level, can help to control the influence they inflict on meat quality.

year: 2006

title: Barriers and facilitators to Oranga Tamariki access: Wāhine voices from Te Whakaruruhau

authors: Mcleay, Ana

abstract: This thesis examines how wāhine supported by Te Whakaruruhau Waikato Women’s Refuge experience Oranga Tamariki (OT) in the context of intimate partner violence (IPV), and what barriers and facilitators shape their access to services. Within a Community-Based Participatory Research approach, influenced by Kaupapa Māori and Mana Wahine principles, qualitative data were collected through semi-structured, kanohi ki te kanohi interviews with six wāhine and kaimahi. Reflexive thematic analysis identified seven themes, grouped into two overarching clusters: barriers and facilitators to OT access. Barriers were pervasive and cumulative, encompassing relational harm, negligence, fear and risk, and cultural tokenism. Facilitators - collaborative advocacy, strengths-based practice, and procedural justice - were comparatively rare and often dependent on external supports rather than systemic provision.

Mapping these findings against Te Hā o Whānau, an access framework, revealed that barriers emerged where tikanga manaakitanga, tikanga whakawhanaungatanga, and tikanga rangatiratanga were absent, while facilitators aligned with their enactment. Te Hā o Whānau conceptualises access as a relational and culturally grounded process inseparable from wellbeing, making it both conceptually robust and uniquely suited to Aotearoa. The analysis demonstrates that OT, as currently structured, undermines whānau wellbeing through systemic practices that erode mana, restrict autonomy, and compromise safety. In the immediate term, strengthened collaborative advocacy offers some protection and support, but meaningful change requires systemic transformation.

Future research should examine how Te Hā o Whānau might be further operationalised across different service contexts and explore experiences of wāhine and whānau with OT in a variety of contexts to build a fuller understanding of access and wellbeing in child welfare.

text: Barriers and facilitators to Oranga Tamariki access: Wāhine voices from Te Whakaruruhau This thesis examines how wāhine supported by Te Whakaruruhau Waikato Women’s Refuge experience Oranga Tamariki (OT) in the context of intimate partner violence (IPV), and what barriers and facilitators shape their access to services. Within a Community-Based Participatory Research approach, influenced by Kaupapa Māori and Mana Wahine principles, qualitative data were collected through semi-structured, kanohi ki te kanohi interviews with six wāhine and kaimahi. Reflexive thematic analysis identified seven themes, grouped into two overarching clusters: barriers and facilitators to OT access. Barriers were pervasive and cumulative, encompassing relational harm, negligence, fear and risk, and cultural tokenism. Facilitators - collaborative advocacy, strengths-based practice, and procedural justice - were comparatively rare and often dependent on external supports rather than systemic provision.

Mapping these findings against Te Hā o Whānau, an access framework, revealed that barriers emerged where tikanga manaakitanga, tikanga whakawhanaungatanga, and tikanga rangatiratanga were absent, while facilitators aligned with their enactment. Te Hā o Whānau conceptualises access as a relational and culturally grounded process inseparable from wellbeing, making it both conceptually robust and uniquely suited to Aotearoa. The analysis demonstrates that OT, as currently structured, undermines whānau wellbeing through systemic practices that erode mana, restrict autonomy, and compromise safety. In the immediate term, strengthened collaborative advocacy offers some protection and support, but meaningful change requires systemic transformation.

Future research should examine how Te Hā o Whānau might be further operationalised across different service contexts and explore experiences of wāhine and whānau with OT in a variety of contexts to build a fuller understanding of access and wellbeing in child welfare.

year: 2025