title: Prolactin delays hair regrowth in mice

authors: Craven, A.J.

abstract: Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in regulating follicle cycling. In this study, the relationship between profiles of circulating prolactin and the first post-natal hair growth cycle was examined in female Balb/c mice. Prolactin was found to increase at 3 weeks of age, prior to the onset of anagen 1 week later. Expression of PRLR mRNA in skin increased fourfold during early anagen. This was followed by upregulation of prolactin mRNA, also expressed in the skin. Pharmacological suppression of pituitary prolactin advanced dorsal hair growth by 3.5 days. Normal hair cycling was restored by replacement with exogenous prolactin for 3 days. Increasing the duration of prolactin treatment further retarded entry into anagen. However, prolactin treatments, which began after follicles had entered anagen at 26 days of age, did not alter the subsequent progression of the hair cycle. Skin from PRLR-deficient mice grafted onto endocrine-normal hosts underwent more rapid hair cycling than comparable wild-type grafts, with reduced duration of the telogen phase. These experiments demonstrate that prolactin regulates the timing of hair growth cycles in mice via a direct effect on the skin, rather than solely via the modulation of other endocrine factors.

text: Prolactin delays hair regrowth in mice Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in regulating follicle cycling. In this study, the relationship between profiles of circulating prolactin and the first post-natal hair growth cycle was examined in female Balb/c mice. Prolactin was found to increase at 3 weeks of age, prior to the onset of anagen 1 week later. Expression of PRLR mRNA in skin increased fourfold during early anagen. This was followed by upregulation of prolactin mRNA, also expressed in the skin. Pharmacological suppression of pituitary prolactin advanced dorsal hair growth by 3.5 days. Normal hair cycling was restored by replacement with exogenous prolactin for 3 days. Increasing the duration of prolactin treatment further retarded entry into anagen. However, prolactin treatments, which began after follicles had entered anagen at 26 days of age, did not alter the subsequent progression of the hair cycle. Skin from PRLR-deficient mice grafted onto endocrine-normal hosts underwent more rapid hair cycling than comparable wild-type grafts, with reduced duration of the telogen phase. These experiments demonstrate that prolactin regulates the timing of hair growth cycles in mice via a direct effect on the skin, rather than solely via the modulation of other endocrine factors.

year: 2006

title: A process mining technique using pattern recognition

authors: Liesaputra, Veronica

subjects: computer science

abstract: Several works have proposed process mining techniques to discover process models fromevent logs. With the existing works, mined models can be built based on analyzing the relationship between any two events seen in event logs. Being restricted by that, they can only handle special cases of routing constructs and often produce unsound models that do not cover all of the traces in the logs. In this paper, we propose a novel technique for process mining based on using a pattern recognition technique called Maximal Pattern Mining (MPM). Our MPM technique can handle loops (of any length), duplicate tasks, non-free choice constructs, and long distance dependencies. Furthermore, by using the MPM, the discovered models are generally much easier to understand.

text: A process mining technique using pattern recognition Several works have proposed process mining techniques to discover process models fromevent logs. With the existing works, mined models can be built based on analyzing the relationship between any two events seen in event logs. Being restricted by that, they can only handle special cases of routing constructs and often produce unsound models that do not cover all of the traces in the logs. In this paper, we propose a novel technique for process mining based on using a pattern recognition technique called Maximal Pattern Mining (MPM). Our MPM technique can handle loops (of any length), duplicate tasks, non-free choice constructs, and long distance dependencies. Furthermore, by using the MPM, the discovered models are generally much easier to understand.

year: 2015

title: Media coverage of 'decades of disparity' in ethnic mortality in Aotearoa.

authors: Hodgetts, Darrin

subjects: psychology

abstract: For some time we have known that factors such as economic prosperity, community cohesion, and social justice bear on health. These societal influences are particularly pertinent to the health of indigenous groups, such as Maori, who are still responding to processes of colonization. In July 2003 the New Zealand Ministry of Health published a report entitled  Decades of Disparity , which proposed (among other things) that neoliberal policies of the last two decades impacted negatively on mortality rates for Maori and Pacific peoples, when compared with Pakeha. In this article we explore media coverage of this report through analyses of media releases, radio, television and newspaper items. It is argued that as the story evolved media increasingly challenged the importance of societal determinants of health, preferring individual level explanations. As a result coverage failed to give due emphasis to structural health concerns for Maori, which necessitate social change.

text: Media coverage of 'decades of disparity' in ethnic mortality in Aotearoa. For some time we have known that factors such as economic prosperity, community cohesion, and social justice bear on health. These societal influences are particularly pertinent to the health of indigenous groups, such as Maori, who are still responding to processes of colonization. In July 2003 the New Zealand Ministry of Health published a report entitled  Decades of Disparity , which proposed (among other things) that neoliberal policies of the last two decades impacted negatively on mortality rates for Maori and Pacific peoples, when compared with Pakeha. In this article we explore media coverage of this report through analyses of media releases, radio, television and newspaper items. It is argued that as the story evolved media increasingly challenged the importance of societal determinants of health, preferring individual level explanations. As a result coverage failed to give due emphasis to structural health concerns for Maori, which necessitate social change.

year: 2004