NIHR Global Health Research Centres 1: Community Management of Long-Term Conditions in Latin America. A UK and low-and-middle-income-country (LMIC) partnership that aims to strengthen community-based care for people with diabetes, cardiovascular disease, respiratory conditions and mental health problems in Latin America. The partnership will develop a world-class research centre with a regional focus in three Latin American countries – Bolivia, Colombia and Guatemala, to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with longterm NCDs, including those from often neglected indigenous communities. Supported by Queen Mary University of London (UK), the Centre will link a leading university in Colombia, Universidad Javeriana, as a regional hub with two universities namely in Bolivia (Universidad Franz Tamayo) and Guatemala (Universidad Rafael Landívar). Studies will investigate the best way to manage long-term conditions within the community. The approach involves using resource-oriented interventions that help people use their strengths and resources to reduce lifestyle factors and behaviours linked to developing long-term conditions. This research will adapt and test these interventions to see whether they have a beneficial effect and to investigate the best way to deliver them in health care services. The research will be implemented from 2022 to 2027. The project will develop the skills of local researchers and clinicians to help sustain the Centre and increase impact. A PhD and Masters programme will run in Colombia to provide formal training to students from all three countries and will help us develop a network of researchers, linking them with others in the region and internationally. The research will be developed and discussed in collaboration with advisory groups. These groups will involve people with long-term conditions, clinicians in community services, community organisations and representatives of local governments. There will be a particular focus on people from indigenous communities as active participants and collaborators, as the impact of long-term conditions is greatest for indigenous people. The project activities will begin from October 2022 and end in September 2027. The overall objective of this project is to build a world-class research centre with a regional focus in Latin America to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with long-term Non-Communicable Diseases (NCDs), including those from often neglected indigenous communities. Short-term aims: build relationships between partners to establish a shared vision, link with local stakeholders, initiate the postgraduate training programme, and identify future research leaders. Medium-term: consolidate capacity strengthening activities through cross cutting, high quality and priority driven research studies testing effectiveness and implementation of appropriate interventions for patients with long-term NCDs. Long-term: sustain and grow the Centre through a critical mass of researchers with regional and international collaborations, complementary skill sets and top-level expertise to lead research groups and generate further funding; the Centre will provide relevant research evidence and influence policies to improve health and social outcomes for patients with NCDs.