Assessment of Point of CaRe creatinine testing In pregnancy: a feasibilty Cohort sTudy in Sierra Leone (APRICOT-SL) Background: Every day, approximately 800 women die in pregnancy or childbirth. 99% of all of these deaths occur in the developing world.  Women with limited access to healthcare are at the greatest risk. Many women die in pregnancy because problems are recognised too late. We have experience using a simple, accurate, handheld device (CRADLE VSA) to measure blood pressure and pulse with minimal skill. It uses a 'traffic light' system; the device tells the user if the blood pressure and pulse measurements are normal (green), worrying (amber) or severely abnormal (red) thus highlighting those who are unwell;  however, further work is needed to identify women at greatest risk of death.    Our previous work in Africa showed that women with raised creatinine (a marker of kidney function) indicating acute kidney injury (AKI) were more likely to die.  AKI is the sudden loss of kidney function and many cases are preventable. AKI leads to an increase in number of all pregnancy complications. Costs of AKI are high due to longer length of stay and extra treatment costs, especially if life-saving dialysis is needed. Longer term problems for the mother after AKI including chronic kidney disease, heart disease and pre-eclampsia (high blood pressure and urine protein) in future pregnancies.   Early delivery of the baby, if the mother has AKI, also may lead to infant death and short and long term health problems including future chronic kidney disease.  Point of care testing of creatinine (POC-Cr) on finger prick blood is ideal for low income settings as blood taking and laboratory processing are not required.  But POC-Cr testing in pregnancy to identify AKI at early stages, when treatments are likely to be successful, has not been performed. In the future we think that preventing AKI in pregnancy using POC-Cr in low income settings could lead to a reduction in death of mother and baby.  The aim of this study is to work out:  -How easy it is to do POC-Cr testing in pregnant or postpartum women: we will measure number of test failures, time taken for training and time taken for testing -How accurate POC-Cr testing is compared to routine blood creatinine concentration testing  -Whether POC-Cr testing is acceptable to health care providers and women -How many women are at risk of AKI and how many develop AKI -How long it takes to complete a POC-Cr study in pregnancy and analyse the findings  -What increase in POC-Cr testing value from study entry and at 6-8 hours indicates the likely development of AKI at 24 hours?  -An estimate of the reduction in AKI rate if repeat POC-Cr testing and training to treat AKI is used  Method: We will recruit 2000 pregnant women with abnormal CRADLE VSA readings.  All women will have:  i) POC-Cr at admission/at time of AKI event and again after 6-8 hours ii) Blood creatinine test at admission/ at time of AKI event again at 24 hours   Run-in period (6 months): 1000 women - POC-Cr results will not be seen by the clinical team.  We will compare POC-Cr results with blood laboratory tests.  We will calculate the number of women who develop AKI from blood creatinine changes at 24 hours and work out what increase in POC-Cr measured at 6-8 hours is best at predicting which women get AKI at 24 hours.  Intervention period (6 months): 1000 pregnant women - POC-Cr results will be seen by the clinical team.  The clinical team will also have training in AKI care and it will be recommended that this is given to women who have a rise POC-Cr measured at 6-8 hours which predicts that they might develop AKI at 24 hours.  We will compare how many women get AKI in the run-in period and in the intervention period.    Next steps: The results of this study will be used to design a large international study which will work out if POC-Cr testing can reduce the number of cases of AKI, maternal and neonatal death in low income countries. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.