devinitorg/iati-policy-markers huggingface dataset:
The relations and susceptibility to invasive bahip between malarial anaemia, neutrophil functioncterial disease. IIB  Research Boards Sep/Oct 2016  RM 2017 award looking at the mechanisms underlying the production of natural mosquito repellents by human beings in Gambia The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
The impact of COVID-19 on primary health care service provision and utilisation in Tanzania, Sierra Leone and the Democratic Republic of Congo MRC GECO COVID award to look at whether the attendance of routine services, like antenatal care, immunisations and HIV treatment services, have been affected by the COVID-19 pandemic in 3 countries in East, West and Central Africa. COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
The DOMINO Study: Measuring and mitigating the indirect effects of COVID-19 on TB and HIV care in Indonesia MRC GECO COVID award to measure and mitigate the indirect effects of COVID-19 on TB and HIV care in Indonesia COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Child malnutrition& Adult NCDs-Generating Evidence on mechanistic links in Jamaica, Malawi & Ethiopia to inform future policy/practice (CHANGE study) Severe malnutrition in early childhood is a major public health concern globally. This has serious consequences: - Short term: for children to survive: malnutrition in all its forms underlies some 45% of all under 5 child deaths worldwide. - Long term: for children to thrive: there is increasing realisation that early life malnutrition contributes to the fast-growing global epidemic of non-communicable diseases (NCDs).   As more children now survive episodes of malnutrition in childhood there is increasing need to understand what causes the long term problems. Evidence on this would lead to: improved early treatment of child malnutrition; improved longer term treatment aiming to reduce long term adverse effects.  In this project we have a unique opportunity to explore three groups of children/adults in: - Jamaica: children suffering from severe malnutrition in the 1980s have been followed up on several occasions already, with scope for further analysis from already collected data. - Malawi: We recently followed up a group of children admitted for severe malnutrition in 2005/6. We plan to both analyse existing data in more depth: also to possible collect new data in future.  - Ethiopia: Individuals who were young children at the time of the great Ethiopia famine of 1983-85 are about to be followed up in a pilot study. Learning from the above two projects will inform and improve plans for the Ethiopia work. We aim to understand what are the long term problems following early child malnutrition and why they occur (the 'mechanisms' by which the two problems are linked)   The work proposed in this applicaiton is background towards the above future project. There are two main activities planned   A) Review of exisiting evidence: we will search the scientific literature to better understand what other have found to date re links between early life malnutrition and adult NCDs. Through this we will identify key knowledge gaps to target in future work.  B) Collaborator meeting - we will bring together the teams working on the above three groups of children to: learn from each other and share experiences. Through this better future work will be possible and there is great potential to enhance the overall learning compared to following each group as a stand-alone. This meeting will be organised in Ethiopia in Autumn 2019: we will invite a number of key experts to make detailed plans for future work. The Ethiopia/Malawi/UK teams will also visit Jamaica (the most advanced/experienced group) to learn from their experience and thus help plan better future projects in Malawi and Ethiopia. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
The role of improved housing in the African malaria recession The aim of this research will be: 1)to test different methods to measure outcomes and collection of basic epidemiology data, 2)understand the intervention needs of the target population,3)to refine the intervention, 4)to assess acceptability and feasibility of the intervention among schoolgirls, parents and teachers. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Indigenous peoples responding to Covid-19 in Brazil: social arrangements in a Global Health emergency MRC GECO COVID award to identify indigenous responses and help to mobilise strategies to mitigatethe servere impact of the pandemic on indigenous people in Brazil. COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Studies towards infectious disease elimination on the Bijagos Archipelago of Guinea Bissau GCRF Foundation Infections 2016 The studies within this grant, will inform the design of new strategies for the elimination of Malaria and Neglected Tropical Diseases that can be evaluated in the Bijagos Islands. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Cambridge Alliance to Protect Bangladesh from Long-term Environmental Hazards (CAPABLE) UKRI GROW award - CAPABLE (Cambridge Programme to Assist Bangladesh in Lifestyle and Environmental risk reduction) will recruit 100,000 people from rural Bangladesh and Dhaka to gather data. Engineers, sociologists, health researchers and a host of other disciplines will t The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
GCRF: Tobacco control capacity programme Working with researchers in South Asia and Sub-Saharan Africa, and offering training and research support, UK-based researchers hope to partner with local academics to develop and implement approaches to tackling Asian and African nations’ tobacco consump The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Nutrition and the epigenome: early environmental factors influencing human developmental programming MRC PSMB award seeking to better understand HOW diet affects the laying down of these methylation marks, WHICH areas of the methylome are especially sensitive to such influences, HOW they influence the development of the placenta and fetus, and ultimately The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
MICA: New combination therapy against MDR TB targeting the respiratory chain Tuberculosis (TB) is the main cause of deaths related to antimicrobial resistance.  In 2016, there were an estimated 10.4 million new TB cases worldwide, and 1.7 million TB-associated deaths.  Multi -drug-resistant (MDR) TB is on the rise and globally, the average cure rate for MDR-TB is only 54% and only 30% for extensively drug resistant TB (XDR-TB). TB is a disease of poverty and presently, 95 % of the TB-related deaths occur in LMICs.  The proposed activities are primarily and directly relevant to the health needs of LMIC and therefore ODA compliant  New combination therapies that can overcome current resistance mechanisms are urgently required.  Here, we wish to validate an exciting new therapeutic approach of targeting multiple respiratory chain components of Mycobacterium tuberculosis, the causative pathogen of TB.  The co-investigators, assembled from both academia and the pharmaceutical industry, are uniquely placed to exploit this strategy possessing (i) extensive domain expertise, (ii) proprietary compound libraries containing selective inhibitors of 4 key respiratory chain components, (iii) access to validated in vitro and in vivo models for assessment of efficacy for drug combinations and (iv) background intellectual property (IP) to both inhibitors and the combinatorial approach.  Our objective is to gain validation of this approach using gold-standard in vitro and vivo disease models of TB and to identify the combination of targets eliciting the optimal antitubercular effect which are most likely to be of value in the clinic. In addition, we will also investigate the potential of inhibitor combinations, in reducing the emergence of new drug resistance, thus potentially extending the lifetime of any new therapeutic solution.  The resulting information will inform and aid in prioritization of drug discovery and development programs that aim to identify inhibitors of respiratory chain components that, when used together, should contribute sterilizing activity to novel drug regimens for MDR-TB, resulting in shorter treatment times for patients. Ongoing discovery programs that will directly benefit from the research output include our own and those of our industrial partner; in addition, we expect the data generated to inspire additional TB discovery and development programs in the wider TB community. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Supporting relatives of children with Beta-thalassemia major in Pakistan to make informed decision about cascade screening The World Health Organization has designated the control of beta-thalassaemia major in developing countries a priority. Pakistan has a huge economic and welfare burden due to beta-thalassaemia major. To address this burden, the government funded the provincial 'Punjab Thalassaemia Prevention Project' (PTPP). One of the priorities of the PTPP is to facilitate cascade screening, that is, identify and offer carrier testing to biological relatives to enable them to make informed marital and reproductive decisions.  However, the uptake of carrier screening by relatives is low and our qualitative research shows that relatives are unlikely to be making informed decision to decline carrier testing. Therefore, the aim of this project is to develop and assess the acceptability of a decision support intervention for relatives (DeSIRe) of children with beta-thalassemia major to facilitate informed decision-making about cascade screening.  In this project, we will develop the DeSIRe by working closely with parents and relatives of children with beta-thalassaemia major and health professionals in the PTPP. The DeSIRe will be designed to support informed decision-making about cascade screening.  It will include a decision aid for relatives and training for the PTPP professionals responsible for cascade screening (field officers). The DeSIRe will be tested within routine practice by PTPP field officers.  We will explore if it is (i) feasible to train PTPP field officers to deliver the DeSIRe, (ii) feasible to deliver the DeSIRe in routine practice and (iii) acceptable to parents and relatives of children with beta-thalassaemia major, and PTPP field officers. We will evaluate the impact of the DeSIRe in a future project (trial) by assessing if relatives are making informed decisions about cascade screening.  Furthermore, to support the implementation of the DeSIRe more widely (nationally in Pakistan and in other low-middle-income countries), we will develop a toolkit and make this available via a website linked to the PTPP website.   Similar to our previous research in Pakistan, we will use a combination of qualitative and quantitative methods to explore the views of parents and relatives of children with beta-thalassaemia major and PTPP field officers. Also, throughout the project, we will engage in two-way discussions with key stakeholders (e.g. PTPP professionals, policy makers, and representatives of the Thalassaemia Society Pakistan NGO) via 'expert panel' meetings to guide the development of the intervention by reviewing drafts of the DeSIRe produced by the research team. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
SARS-CoV-2 infection, transmission dynamics and household impact in Malawi (SCATHIM) MRC GECO COVID award to determine the transmission dynamics, determinants and socio-economic impact of SARS-CoV-2 infection in households located in urban mediumdensity, urban high-density and rural-high density locations in Malawi, Africa COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Feasibility of implementing an integrated hybrid model of service delivery for AGYW sexual and reproductive health in South Africa Adolescent girls and young women (AGYW) experience significant health challenges including HIV infection, unwanted teenage pregnancies and sexually transmitted diseases in South Africa. Challenges exist with the uptake and utilization of sexual and reproductive health services for AGYW and there are a number of missed opportunities with the health system to provide prevention and care to AGYW.  There is a renewed drive for service integration by policy makers to integrate SRH services with newly emerging HIV prevention and treatment services, in addition to scaling up access to prevention, care and treatment of STI's at a primary healthcare level. Current isolated service delivery models adds time and cost to clinic facilities and may be seen as a barrier to accessing care, as young people may have less access to cash, competing demands and less control over their time. There is limited data on effective delivery models for integrated interventions for young populations, therefore this study aims to determine the feasibility of implementing an integrated hybrid model of service delivery for adolescent girls and young women (AGYW) sexual and reproductive health (SRH) at selected facilities in South Africa. The integrated service delivery model will be a hybrid model comprising of both integration of contraceptive, STI/HIV transmission prevention and mental health screening with linkage to care services for HIV treatment, PrEP and psychosocial support. The linkages to appropriate care should be facilitated by health connectors. In order to determine whether such an intervention would be feasible to implement at selected facilities, this study will 4 elements, namely acceptability, demand, practicality and adaptation using the following objectives: (1) determine client, provider and key informant acceptability of the integrated hybrid model for SRH service delivery for AGYW, (2) assess demand and preference for integrated SRH services amongst AGYW, (3) determine the practicality of delivering integrated hybrid model for SRH service delivery for AGYW in a resource constrained setting, and (4) determine current level of integration and the adaptations needed to implement the integrated hybrid model for SRH service delivery for AGYW. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Classification of oral lesions using deep learning for early detection of oral cancer For the majority of cancers, early detection results in better survival. Oral cancer is one of the few cancers that is visible and many of these cancers are preceded by a potentially malignant lesion where medical intervention can prevent the development of cancer. Taken together, oral cancer presents an opportunity for early detection. However, identifying which oral lesion has a propensity to become oral cancer is not straightforward without specialised training and this problem is confounded by the lack of specialists who are trained in this expertise particularly in low- and middle-income countries, where the majority of oral cancers are diagnosed. One innovative approach to overcome this is to develop an artificial intelligence algorithm to classify oral lesions into those that are benign and those that are potentially malignant or are occult cancer so that patients can be triaged accordingly to receive appropriate clinical management. In this project, we propose to work within a multi-disciplinary, international team to collate a library of images from existing and prospective collections that will facilitate the development of an artificial intelligence algorithm that will be tested and validated. The outcome of this project will pave the way for further rigorous testing, development of an App incorporating this automated tool and clinical validation for the early detection of oral cancer. The development of an automated tool for the classification of oral lesions will facilitate the identification of patients most at risk to develop oral cancer so that these individuals can be managed appropriately. This project is particularly impactful in the low- and middle-income countries as the majority of the global burden of oral cancer is found in these countries. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Healthcare and Socio-economic Impacts of COVID-19 on Patients with Diabetes in Tanzania and Kenya MRC GECO COVID award to explore the experiences of people within Diabetes in Tanzania abd Keya  type 2 diabetes (T2D) and healthcare providers on managing T2D during COVID-19. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Creating a West African BioResource for Nutritional Genetics and Epigenetics Global Nutrition institutional pump priming award to create a new West African BioResource (WABR). The database will support novel research methods to better understand the complex relationships between diet, nutritional status and infectious and non-comm The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Development and potential reversal of type 2 diabetes: How critical is vitamin A in the regulation of insulin responsiveness and lipid homeostasis? The rapid increase in number of people affected by type 2 diabetes is matter of grave concern. Diabetes is a world-wide problem and has risen from 108 million in 1980 to 422 million in 2014.  In the Philippines, one out of every six Filipino has either pre-diabetes or diabetes. Recent studies have shown that type 2 diabetes develops by excess, yet reversible, fat accumulation in liver and pancreas. There is also some evidence suggesting that vitamin A may contribute to this condition, but the underlying mechanisms are not yet fully understood. Furthermore, it is not yet clear why some people develop type 2 diabetes faster than others, even with a similar liver fat content.  The proposed study therefore aims to understand if vitamin A increases the metabolic stress that is caused by a fatty liver, and if changes in vitamin A metabolism could contribute to an increase in liver fat, therefore inducing a vicious cycle of liver fat accumulation and acceleration of the development of diabetes.  The study will finally evaluate if diet-induced weight loss among diabetics in the Philippines could improve all aspects of diabetes control, and if a low energy liquid diet is culturally acceptable.  Finally, the project may help to develop new prevention strategies to enable the Ministry of Health to reduce the burden of diabetes and its complications in the Philippines. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.