devinitorg/iati-policy-markers huggingface dataset:
Exploring Narrative Storytelling as Mental Health Support for Women Experiencing Gender-based Violence in High Prevalence Settings Our partnership brings together medical experts, poets, civil society organisations, and feminist activists working on GBV in the UK and across the Middle East, North Africa and Asia to develop a narrative storytelling approach to gender-based violence (GBV) against women in high prevalence settings. Setting that have a high prevalence of GBV (where over 50% of women experience violence in their lifetime) are often countries or regions where GBV is publicly accepted as a normal part of women's everyday lives and condoned by state inaction. This is the case in the regions and countries included in our proposal, namely: Afghanistan, Kashmir (India), Tunisia, Kurdistan (Iraq), and Turkey. Storytelling is widely used as a means of personal expression in response to violence in these contexts, drawing on their shared socio-cultural origins as ancient Persian societies. Our collaboration draws on this shared history and the cultural importance of storytelling to develop a culturally-relevant intervention for women experiencing gender-based violence. We do this through four main activities: (1) collaboratively designing a potential storytelling intervention based on our team's diverse expertise from the medical sciences (psychiatry, psychology) and the humanities (humanitarian ethics, gender and women's studies, literature studies, poetry); (2) tailoring and piloting the intervention with women residing in safe houses in Kurdistan (Iraq); (3) developing an online networking tool to foster collaborations related to the pilot study and build future project ideas; and (4) creating a collection of stories based on women's accounts to reach a broad national and international audience to effect social change. This is an innovative approach to creating a culturally-relevant intervention to address the mental health needs of women experiencing GBV in high prevalence settings and will ideally challenge discourses that accept violence in the lives of women as part of a broader project of social change. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Developing a multiplex serology panel to detect and quantify Epstein-Barr virus infection MRC/Global Cancer Research Grant to study will develop and validate a panel capable of measuring and quantifying the amounts of EpsteinBarr virus biomarkers. The panel will be part of a pilot casecohort study including 200 each of Nasopharyngeal Cancer, g The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
GCRF:Thanzi la Onse (Health of All):  Frameworks and analysis to ensure value for money health care - developing theory, changing practice UKRI GROW award - Thanzi la Onse, which means ‘Health of All’ in a Malawian language, will construct a model of Malawi’s entire health system, and then test various interventions within it. The model will map not just the health of Malawians but also the country’s resources and how the health system operates. This activity benefits Malawi and Uganda. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
The risk of a chronic clinical condition following a previous hospitalisation by a psychiatric disorder: a linkage nationwide study in Brazil Multimorbidity is the occurrence of more than one chronic condition at a time. This can include conditions like cardiovascular disease, a mental health condition of long duration, such as a mood disorder or dementia or an infectious disease of long duration, such as Tuberculosis.  Multimorbidity increases with age and also presents certain distinct patterns related to sex. On the other hand, mental disorders are commonly found together and usually have consequences on other chronic physical condition that the patient may have. Mental health disorders, in particular depression, represent an important risk factor for premature mortality. Multimorbidity can also increase the treatment costs, as subjects with depression will cost 50% more to health systems than those with one chronic condition alone. Cardiovascular diseases are also found to co-occur with depression, this might happen because these patients show difficulties in following their GP 's recommendations.  It is of note that women seem to be at higher risk of morbidity from cardiovascular disease, while they are also at a higher risk of depression suggesting gender-specific mechanisms. Analysis of a recent health survey in adult Brazilians observed that the prevalence rate of multimorbidity are higher among women compared to men, among older people and those with lower educational level.  We at the Center for Data Integration and Knowledge for Health (CIDACS) have access to very large datasets, which would commonly be known as Big Data. This data comprises information from Brazilian subjects that were listed or benefited by one of the several social programmes or were seen in any of the numerous public hospital of the country's universal health system.  This project aims at increasing knowledge over the relationship of mental disorders and other chronic conditions to ameliorate the lives of those affected. More specifically we want to (A) estimate the the risk of hospitalisations or death by diabetes mellitus, cardiovascular diseases or stroke following a hospitalisation due to depressive disorders, alcohol and substance use-related disorders, and schizophrenia;  (B) To estimate the  risk of the occurrence or death by tuberculosis following a hospitalisation due to depressive disorders, alcohol and substance use-related disorders, and schizophrenia; (C)  To investigate how these chronic conditions goes together in clusters and how these patterns evolve over time and ageing. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Implementing genomic surveillance to support SARS-CoV-2 control and mitigation
strategies in the Philippines MRC GECO COVID award to build genomic surveillance and response capacity in the Philippines, where it can inform infection control at local and regional scales COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Can improved housing provide additional protection against clinical malaria over current best practice? A household-randomised controlled trial Malaria remains one of the greatest threats to global public health, with 207 million cases of falciparum malaria and 627,000 deaths occurring in 2012, with over 80% of deaths occurring in Africa. More than 80% of malaria is transmitted indoors at night, so the number of malaria mosquitoes which enter a house is critical for getting the disease - with people living in 'leaky' houses being at most risk. We have shown that closing the eaves (the gap between the top of the wall and the roof) and screening a house can reduce dramatically the number of malaria vectors entering a house. Here we propose to find out whether we can protect children against malaria by modifying half the study houses so that they (1) have a metal roof, (2) closed eaves, (3) screened doors and windows and (4) screened-air bricks which allow the warm air to rise out of the house, but not let any mosquitoes indoors. The other study houses will be left with thatched roofs and open eaves and the children in these houses will serve as a comparison group.  Over the past thirty years a silent revolution in house design has been happening across Africa. The traditional thatched-roofed houses are being replaced steadily by metal-roofed houses as the continent develops. We hope to ride this wave of cultural change and further improve the design of houses to make them healthier to live in. Improved housing has the potential to improve the lives of millions of people across sub-Saharan Africa including Gambia (The). The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Investigating the determinants of health worker performance in Senegal JHSR 1 Full 2014 award to generate new knowledge and understanding of how Performance-Based Financing (PBF) programmes work and influence health workers' performance in Senegal The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Whole System Change in South Africa: Understanding the experience of health system transformation in the Western Cape province (WholeSyst-SA) Twenty years after the ending of apartheid the time is ripe to evaluate South African experience of health system transformation. Much was promised and many changes have been introduced - but how much has been achieved, especially for the most vulnerable and previously disadvantaged groups?  What factors have enabled or constrained change across the public health system, nationally recognised as the leading edge of efforts to improve the health and well-being of vulnerable groups? What lessons does past experience hold for continuing efforts to improve health care and health? What issues need to be tracked over time to generate the evidence needed to support future policy and managerial decision-making?  This proposed grant intends to address these questions. It is jointly submitted by a team of public health system policy-makers/managers and researchers based in the Western Cape (WC) province. As South Africa is a quasi-federal state, the WC provincial government has the constitutional responsibility for ensuring an effective health system for its population. It also has a reputation for having been relatively effective in sustaining implementation of such change over the last 20 years. Examining the particular experience of one province, in comparison with wider national experience, will allow in-depth investigation of South African health system transformation. The project will consider not only what changes have been implemented, with what achievements and challenges, but also what set of political, leadership, organisational and other factors have supported or limited the implementation of change. From this analysis it will seek to identify the pathways to change underpinning health system development in the province. The project team's combination of experience and expertise will support this in-depth investigation.  Better understanding of what the province has achieved and how, set against the national context, will offer insights of relevance across the country, as well as internationally. It will also, more specifically, contribute to generating the evidence base needed to support future policy and management decision-making, by supporting provincial health system monitoring and evaluation activities and identifying related, larger scale research needs. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Household Transmission and Immunity to SARS-CoV-2 among Paediatric Clients of a Primary Care Center in a Low-resource Community in Rio de Janeiro MRC GECO COVID award to study the household transmission dynamics of SARS-CoV-2 in a slum in Rio de Janeiro, Brazil and to estimate the immunity of the study population against the new virus. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Ensuring access to health care and medicines during COVID-19: critical challenges and feasible policy options for the medicines retail sector MRC GECO COVID award to understand and mitigate the vulnerability of supply and access to medicines within the Uganda health system COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Drivers of Resistance in Uganda and Malawi: The DRUM Consortium The discovery and development of antibiotics is one of the great scientific achievements of the 20th Century, however it rapidly became clear that bacteria quickly become resistant to these lifesaving agents, and the spread of antibiotic-resistant bacteria is now a problem of global concern. The poorest nations on Earth frequently have the greatest burden of severe and life threatening infections, and these nations are likely to suffer most from the spread of untreatable bacteria. There is much that is unknown about how antibiotic resistance spreads globally and this is particularly true of sub-Saharan Africa, where diagnostic laboratories are not commonly available. The "Drivers of Resistance in Uganda and Malawi" or DRUM Consortium will address how human behaviour and antibacterial usage in the home, around animals and in the wider environment in urban and rural areas of Uganda and Malawi contributes to the spread of antibiotic resistance in bacteria. The consortium is especially interested in the common bacteria E. coli and K. pneumoniae. E. coli is an example of a bacteria that often causes infections in the community, but may also spread around hospitals, whereas K. pneumoniae is a key cause of hospital acquired infections, particularly amongst vulnerable groups such as premature babies. We have chosen to study these bacteria together as they are from the same family and are able to share traits that make them resistant to antibiotics.  The DRUM consortium plans to investigate which aspects of behaviour are most important in spreading antibiotic resistance by surveying human behaviour in relation to antibiotics, water, sanitation and hygiene and by investigating bacterial behaviour in response to these stimuli. We plan to use cutting edge mathematical techniques to "model" which behaviours are most important and then use this information to work with policy experts in Uganda and Malawi to design potential interventions to prevent them from spreading further. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Control of gene expression in trypanosomes: Defining the nuclear lamina Parasitic protozoa are important agents of disease, and afflict a major proportion of the world's population. In evolutionary terms parasites are very different to their hosts, and this is frequently reflected in the presence of a great many unique or unusual mechanisms that underpin their biology. This aspect presents multiple opportunities for the understanding of pathogenesis and also the possibility of identifying therapeutic targets.   In trypanosomes, which as a group cause Sleeping sickness, Chagas' disease and Kala Azar (visceral leishmaniasis) and a great many other diseases, immune evasion is vital for survival and transmission. African trypanosomes are highly reliant on antigenic variation for their longterm survival - the process is so successful that trypanosomes can infect their host for many months and in some cases years. The primary mechanism of immune evasion is antigenic variation, the periodic switching of the parasite surface through sequential expression of immunologically distinct forms of the variant surface glycoprotein (VSG). Understanding VSG expression is central to unravelling the mechanisms of trypanosome virulence and is a longstanding goal in the field.   At the rim of the nucleus DNA is compacted into heterochromatin, which is transcriptionally silent and acts as a mechanism for the inactivation of genes placed there. To ensure that only one VSG is expressed at a time trypanosomes use heterochromatin as a store for all potentially expressed VSG genes except one. Recently we have uncovered a system of proteins that are localised to the rim of the trypanosome nucleus, and which regulate heterochromatin, nuclear structure and other functions. Most remarkably these proteins are distinct from those that make up the equivalent system in the host. This application proposes to interrogate in detail the manner in which the proteins comprising this system are organised, how they function and ultimately how they regulate VSG gene expression. The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Covid-19 Excess Mortality and Seroprevalence study for MRC Unit The Gambia at LSHTM MRC GCRF Award conducting a Covid-19 Excess Mortality and Seroprevalence study for MRC Unit The Gambia at LSHTM COVID-19 The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
An investigation of interventions to increase uptake of HIV self-testing and linkage to post-test services among higher education students in Zimbabwe Adolescents and young people in Africa have the worst health outcomes of adolescents and young people globally, in large part because of the high rate of new HIV infections, particularly among young women. Despite this, young people are less likely to know their HIV status than older adults and as such are less likely to benefit from prevention and treatment options. The population of young Africans is set to double in the next 30 years meaning that if nothing is done to improve young people's access to HIV prevention and care, the number of new infections in young people will also double. This project targets young students attending higher education institutions with a novel intervention, HIV self-testing, aimed at improving their uptake of HIV testing and supporting them to take up prevention and care services. HIV self-testing, where people test themselves for HIV infection, has been shown to be safe and accurate and of importance here, highly acceptable to young people who desire privacy and autonomy when testing. I propose to compare the effectiveness and cost and cost effectiveness of two models of distributing HIV self-testing among students, in a trial where higher education institutions are allocated by chance to one of two distribution models. Outcomes include: i) uptake of self-testing, ii) linkage to HIV prevention and care services depending on their HIV result and, iii) cost per person tested, diagnosed positive and started on treatment or preventive service.  The two HIV self-test distribution models to be compared are a peer-led plus mass-media supported model with a mass media only model. I will also develop an internet based tool to measure distribution of self-test kits and support and measure subsequent engagement with services. I will then explore how to adapt these self-testing models for young people to other settings (eg schools or workplaces) and to support prevention and care for other chronic diseases in young people (eg hypertension or poor mental health). The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.
Increasing eye research capacity and capabilities to tackle the burden of blindness in India: a research-based UK-India Collaboration (ORNATE INDIA) UKRI GROW award - 69 million Indians suffer from diabetes, which can lead to deterioration of the eye which can lead to blindness. Researchers from institutes and eye hospitals in the UK and India will trial a new handheld eye camera and a home blood test that picks up sig The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world.