Sentence:  Although we are still far from a complete understanding of these problems , as a first approximation , it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic cortical discharges account for <WSD>major</WSD> changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances , in experimental and clinical neurosis , and as the result of psychopharmacological agents . 
Meaning of the word marked with <WSD> tags:  greater in number or size or amount