Sentence:  Adrian, whose health had always been weak, now suffered considerable <WSD>aggravation</WSD> of suffering from the effects of his wound. 
Meaning of the word marked with <WSD> tags:  The act of aggravating, or making worse; used of evils, natural or moral; the act of increasing in severity or heinousness; something additional to a crime or wrong and enhancing its guilt or injurious consequences.