Sentence:  "Guildenstern". The King, sir— / "Hamlet". Ay, sir, what of him? / "Guildenstern". Is in his retirement, marvellous <WSD>distemper'd</WSD>. / "Hamlet". With drink, sir? / "Guildenstern". No, my lord; rather with choler. 
Meaning of the word marked with <WSD> tags:  To derange the functions of, whether bodily, mental, or spiritual; to disorder; to disease.