Sentence:  Because dexamethasone and naloxone successfully reduce body weight, blood lipid and glucose levels, and blood pressure in Obese/SHR (to be published), the question arose whether prevention of corpulency by daily exercise would also <WSD>disentrain</WSD> the genetically programmed obesity and hypertension. 
Meaning of the word marked with <WSD> tags:  To disrupt a body's homeostatic patterns.