Sentence:  The expense of this type of organization in religious life , when one recalls the number of city churches which deteriorated beyond repair before being abandoned , raises <WSD>fundamental</WSD> questions about the principle of Protestant survival in a mobile society ; nonetheless , the prevalence of economic integration in congregations illumines the nature of the Protestant development . 
Meaning of the word marked with <WSD> tags:  far-reaching and thoroughgoing in effect especially on the nature of something