Sentence:  With some of it on the south and more of it on the north of the great main thoroughfare that connects Aldgate and the East India Docks, St. Bede's at this period of its history was perhaps the poorest and most <WSD>miserable</WSD> parish in the East End of London. 
Meaning of the word marked with <WSD> tags:  In a state of misery: very sad, ill, or poor.