Sentence:  The Mecholyl and noradrenalin tests <WSD>applied</WSD> with certain precautions are reliable indicators of this central autonomic balance , but for the sake of correlating autonomic and clinical states , and of studying the effect of certain therapeutic procedures on central autonomic reactions , additional tests seem to be desirable . 
Meaning of the word marked with <WSD> tags:  put into service; make work or employ for a particular purpose or for its inherent or natural purpose