Sentence:  O lawfull let it be / That I have roome with "Rome" to curſe a while, / Good Father Cardinall, cry thou Amen / To my <WSD>keene</WSD> curſes; for without my wrong / There is no tongue hath power to curſe him right. 
Meaning of the word marked with <WSD> tags:  Acrimonious, bitter, piercing.