Sentence:  As all Ulcers complicated with great Diseases are of difficult Cure, and therefore called <WSD>Cacoethe</WSD>: so these Ulcers labouring under "Intemperies" though they be well handled, are hard of Cure, and may be truly reckoned among the <WSD>Cacoethe</WSD>, malign and rebellious Ulcers. 
Meaning of the word marked with <WSD> tags:  A bad quality or disposition in a disease; a malignant tumour or ulcer.