Sentence:  In an attempt to reverse the downhill <WSD>trend</WSD> by stimulating the bone marrow and controlling any hemolytic component , triamcinolone , 16 mg. daily , was begun on Sept. 26 , 1958 , and continued until Feb. 18 , 1959 . 
Meaning of the word marked with <WSD> tags:  a general direction in which something tends to move