Sentence:  In view of the important role which emotional disturbances play in the genesis of neurotic and psychotic disorders and the parallelism observed between autonomic states and psychological behavior in several instances , it is further suggested that a hypothalamic imbalance may play an important role in initiating mental <WSD>changes</WSD> . 
Meaning of the word marked with <WSD> tags:  a relational difference between states; especially between states before and after some event