Sentence:  There is, however, significant <WSD>acerbation</WSD> of the impact of further episodes of hypoglycemia on cognitive function, so that this risk should be recognized and borne in mind by those receiving or initiating protocols likely to produce such hypoglycemia. 
Meaning of the word marked with <WSD> tags:  Exacerbation, aggravation, deterioration.<ref>"Oxford English Dictionary", 3rd ed., 2005.</ref>