Sentence:  If, however, the early symptoms of insanity be neglected till the brain becomes accustomed to the irregular actions of disease, or till organic changes take place from the early violence of those actions, then the case becomes hopeless of cure. In this situation, in too many cases, the victim of this <WSD>deplorable</WSD> malady is cast off by his friends, thrust into a dungeon or in chains, there to remain till the shattered intellect shall exhaust all its remaining energies in perpetual raving and violence, till it sinks into hopeless and <WSD>deplorable</WSD> idiocy. 
Meaning of the word marked with <WSD> tags:  Lamentable, to be felt sorrow for, worthy of compassion.