Sentence:  It was our good fortune last autumn to escape from the feverish excitement and moral tension of this vast metropolis, from the hurry and <WSD>fret</WSD> of business, the glut of pleasure, the satiety of delight, the weariness of politics, and the exhausting duties of our critical function, into that favoured corner of our fortunate island, the West of England; ... 
Meaning of the word marked with <WSD> tags:  Agitation of the mind marked by complaint and impatience; disturbance of temper; irritation.