Sentence:  Whether this abnormal TSH differs chemically from pituitary TSH , or is , alternatively , normal TSH with its period of effectiveness modified by some other blood constituent , cannot be decided without chemical study of the activity in the blood of these patients and a comparison of the substance <WSD>responsible</WSD> for the blood activity with pituitary TSH . 
Meaning of the word marked with <WSD> tags:  being the agent or cause