Sentence:  Any of the antithyroid drugs , of either type , if given in large enough doses for a long period of time will cause goitre , owing to inhibition of thyroid hormone synthesis , with production of <WSD>hypothyroidism</WSD> . 
Meaning of the word marked with <WSD> tags:  an underactive thyroid gland; a glandular disorder resulting from insufficient production of thyroid hormones