Sentence:  A <WSD>blow</WSD> to this phase of the Central 's operations would have serious economic consequences not only to the railroad itself , but to the 40000 people per day who are provided with efficient , reasonably priced transportation in and out of the city . 
Meaning of the word marked with <WSD> tags:  an unfortunate happening that hinders or impedes; something that is thwarting or frustrating