Sentence:  Cross-examination of genetic and structural information revealed that the <WSD>underwrapping</WSD> or packing deficiency of a protein, ν, is a molecular quantifier of dosage sensitivity [5] precisely because it constitutes a measure of the reliance of the protein on binding partnerships to maintain the integrity of the native fold. 
Meaning of the word marked with <WSD> tags:  A state of being insufficiently desolvated, so that the main chain of hydrogen bonds in a protein are too accessible, rendering the protein unstable.