Sentence:  With some of it on the south and more of it on the north of the great main <WSD>thoroughfare</WSD> that connects Aldgate and the East India Docks, St. Bede's at this period of its history was perhaps the poorest and most miserable parish in the East End of London. 
Meaning of the word marked with <WSD> tags:  A road open at both ends or connecting one area with another; a highway or main street.