Sentence:  Although we are still far from a complete understanding of these <WSD>problems</WSD> , as a first approximation , it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances , in experimental and clinical neurosis , and as the result of psychopharmacological agents . 
Meaning of the word marked with <WSD> tags:  a question raised for consideration or solution