Sentence:  Manganism has been known about since the 19th century, when miners exposed to ores containing manganese...began to totter, slur their speech and behave like someone inebriated. The poisoning was <WSD>irreversible</WSD>, and soon ended in psychosis and death. 
Meaning of the word marked with <WSD> tags:  Incapable of being reversed, recalled, repealed, or annulled.