Sentence:  Any of the antithyroid drugs , of either type , if given in large enough doses for a long period of time will cause <WSD>goitre</WSD> , owing to inhibition of thyroid hormone synthesis , with production of hypothyroidism . 
Meaning of the word marked with <WSD> tags:  abnormally enlarged thyroid gland; can result from underproduction or overproduction of hormone or from a deficiency of iodine in the diet