Sentence:  Three related tribes, the Costanoan, Esselen, and Salinan, living along the California coast to the south of San Francisco Bay used tobacco and <WSD>"toloache</WSD>" (datura). <WSD>"Toloache</WSD>" was taken for vision quests and to initiate boys into manhood. 
Meaning of the word marked with <WSD> tags:  A psychoactive, hallucinogenic preparation made from the plant.