Sentence:  Alice looked at the jury-box, and saw that, in her haste, she had put the Lizard in head downwards ... She soon got it out again, and put it right; ‘not that it <WSD>signifies</WSD> much,' she said to herself; ‘I should think it would be quite as much use in the trial one way up as the other.' 
Meaning of the word marked with <WSD> tags:  To make a difference; to matter ("in negative or interrogative expressions").