Sentence:  Max , in a fit of <WSD>despair</WSD> , takes Alicia and runs off for two marvelous weeks in Burbank ( Fink calls it `` the most wonderful and lovely fourteen days in my whole life '' ) , at the end of which Alicia tragically contracts Parkinson's disease and dies . 
Meaning of the word marked with <WSD> tags:  a state in which all hope is lost or absent