Sentence:  And Mr. Skyros did n't like Angie , but what with Prettyman and three of his boys inside , and not likely to come out - And Angie such a valuable salesman , Prettyman said - All the <WSD>nuisance</WSD> and danger of getting in touch with practically a whole new bunch of boys - Why did everything have to happen at once ? 
Meaning of the word marked with <WSD> tags:  (law) a broad legal concept including anything that disturbs the reasonable use of your property or endangers life and health or is offensive