Sentence:  These advantages also play a role in treatment for special indication such as in patients with neurological problems (e.g. Parkinson's disease), in whom a total replacement leads to a worsening of the underlying disease whereas compartmental reconstruction avoids the effect of somato-<WSD>agnosy</WSD> (loss of sensation of a body part). 
Meaning of the word marked with <WSD> tags:  A deficit in the ability to perceive.