Sentence:  It must be reasonably clear to all who have taken pains to understand the matter that the true issue as regards design is not between Darwinism and direct <WSD>Creationism</WSD>, but between design and fortuity, between any intention or intellectual cause and no intention nor predicable first cause. 
Meaning of the word marked with <WSD> tags:  The belief that a deity created the world, especially as described in a particular religious text, such as the Quran or the Book of Genesis.