Sentence:  These colossal changes necessitate an attempt to adapt the constitution of 1789 to an entirely different kind of civilization from the one for which it was planned. The only significant change made to meet this new civilization is the great American <WSD>maid-of-all-work</WSD>, the Inter-State Commerce Commission. 
Meaning of the word marked with <WSD> tags:  Any person who does a wide range of jobs in a supportive role; a thing that serves a wide range of purposes.