Sentence:  A study of their activity on thyroglobulin has shown that thyroxine is not preferentially released and that the degradation proceeds stepwise with the <WSD>formation</WSD> of macromolecular intermediates ( Alpers , Petermann and Rall , 1956 ) . 
Meaning of the word marked with <WSD> tags:  the act of fabricating something in a particular shape