Sentence:  It is this [the commandment of God], which is the <WSD>manacle</WSD> of melancholy, when menacing ſuicide, and when deaf to every other diſſuaſive, or countroul; which quaſhes the ſilent, lurking purpoſe of diſontent, when misjudging it's preſent, and reckleſs of it's future deſtiny. 
Meaning of the word marked with <WSD> tags:  A fetter, a restriction.