Sentence:  So did the worldes proud "Mistres Rome" at first / Striue with a hard beginning, warr'd with need; / Forcing her strong <WSD>Confiners</WSD> to the worst, / And in her bloud her greatnes first did breed: 
Meaning of the word marked with <WSD> tags:  A person who lives on the confines, boundary or edge; a neighbour.