Sentence:  Although we are still far from a complete understanding of these problems , as a first approximation , it is suggested that <WSD>alterations</WSD> in the hypothalamic balance with consequent changes in the hypothalamic cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances , in experimental and clinical neurosis , and as the result of psychopharmacological agents . 
Meaning of the word marked with <WSD> tags:  the act of making something different (as e.g. the size of a garment)