Sentence:  Natures that haue much Heat, and great and violent deſires and <WSD>Perturbations</WSD>, are not ripe for Action, till they haue paſſed the Meridian of their yeares: As it was with "w:Julius Caesar 
Meaning of the word marked with <WSD> tags:  A small change in a physical system, or more broadly any definable system (such as a biological or economic system)