Sentence:  Homer's entrepreneurial spirit proves altogether overly infectious. Homer gives Barney a pep talk when he encounters him dressed up like a baby handing out fliers (Barney in humiliating costumes=always funny) and it isn't long until Barney has purchased a truck of his own and <WSD>set up shop</WSD> as the Plow King. 
Meaning of the word marked with <WSD> tags:  To establish a business.