Sentence:  Holmes is addicted to the use of <WSD>cocaine</WSD> and other refreshing stimulants ; he is prone to semi catatonic trances induced by the playing of the vioiln ; he is a recluse , an incredible egotist , a confirmed misogynist . 
Meaning of the word marked with <WSD> tags:  a narcotic (alkaloid) extracted from coca leaves; used as a surface anesthetic or taken for pleasure; can become powerfully addictive