Sentence:  Modern man , as Dietrich Bonhoeffer has told us , has `` come of age '' ; and though this process by no means represents an unambiguous gain and is , in fact , marked by the <WSD>estrangement</WSD> from the depths that seems to be the cost of human maturation , it is still a positive step forward ; and those of us who so richly benefit from it should be the last to despise it . 
Meaning of the word marked with <WSD> tags:  separation resulting from hostility