Sentence:  But the operation of lead on the ſyſtem is powerfully ſedative and debilitating, and directly adverſe to exuberant action. Hence in the moſt acute form of the <WSD>ſaturnine</WSD> diſeaſe, opium, (which is ſtrongly ſtimulant on the arterial ſyſtem) is adminiſtered, with ſafety and advantage, in quantites much larger than can be borne in moſt other diſeaſes; [...] 
Meaning of the word marked with <WSD> tags:  Of, pertaining to, or containing lead (which was symbolically associated with the planet Saturn by alchemists).