Sentence:  And ſure, although it was invented to eaſe his mynde of <WSD>griefe</WSD>, there be a number of caveats therein to forewarne other young gentlemen to forstand 
Meaning of the word marked with <WSD> tags:  Pain of mind arising from misfortune, significant personal loss, bereavement, misconduct of oneself or others, etc.; sorrow; sadness. (from early 14th c.)