Sentence:  What wit have we (poor fools) to wit what will serve us, when the blessed Apostle himself in his sore <WSD>tribulation</WSD>, praying thrice unto God to take it away from him, was answered again by God in a manner that he was but a fool in asking that request, but that the help of God's grace in that <WSD>tribulation</WSD> to strengthen him was far better for him, than to take that <WSD>tribulation</WSD> from him? 
Meaning of the word marked with <WSD> tags:  Any adversity; a trying period or event.