Sentence:  I believe , therefore , that we are without exception sinners , by nature <WSD>alienated</WSD> from God , and that Jesus Christ , the Son of God , came to earth , the representative Head of a new race , to die upon the cross and pay the penalty of the sin of the world , and that he who thus receives Christ as his personal Saviour is `` born again '' spiritually , with new privileges , appetites , and affections , destined to live and grow in His likeness forever . 
Meaning of the word marked with <WSD> tags:  arouse hostility or indifference in where there had formerly been love, affection, or friendliness