Sentence:  The contemptible ignorance, credulity, and fraud, which support its tyrannous authority, as a supernatural revelation, and the futile attempt to enforce a belief of its liberal meaning as indispensable to the happiness of mankind, and the universal degradation and miserty which it perpetuates, by the inbred hostility which all its priesthoods have ever evinced towards every improvement that would enlighten and elevate the human mind, have done more to disgust and <WSD>misanthropize</WSD> all ingenuous and rational minds, and to inspire them with a settled aversion for the ways of man and his institutions, than all the other moral and physical evils now experienced in Christendom. 
Meaning of the word marked with <WSD> tags:  To make misanthropic