Sentence:  [I]f luxury <WSD>emaſculate</WSD> the minds of the nobility, enervate the ſinews of the people, render money, and not merit, the paſſport to authority, and, inſtead of the ſtrong and natural ſupport of native valour, ſubſtitute the weak and inefficient prop of mercenary aid: of ſuch a ſtate, however extenſive may be its Commerce, however ample its revenue, the ruin is inevitable. 
Meaning of the word marked with <WSD> tags:  To deprive of masculine vigor or spirit; to weaken; to render effeminate; to vitiate by unmanly softness. (from early 17th c.)