Sentence:  If the argument is accepted as essentially sound up to this point , it remains for us to consider whether the patient 's <WSD>difficulties</WSD> in orienting himself spatially and in locating objects in space with the sense of touch can be explained by his defective visual condition . 
Meaning of the word marked with <WSD> tags:  a condition or state of affairs almost beyond one's ability to deal with and requiring great effort to bear or overcome