Sentence:  But the inclusion of the word “trannie” — a pejorative, in some circles — in the title, and the film's parodic representation of <WSD>transgender</WSD> women, has offended many people. 
Meaning of the word marked with <WSD> tags:  Having a gender (identity) which is different from the sex one was assigned at birth: being assigned male at birth but having a female or non-binary gender or vice versa; or, pertaining to such people. (Compare "transsexual", and the following sense.)