Sentence:  And you wonder if that is why the little man lost his job and his car and stayed drunk about a year before he straightened out and moved to <WSD>St.</WSD> Louis , where he got to be a big unhappy success . 
Meaning of the word marked with <WSD> tags:  the largest city in Missouri; a busy river port on the Mississippi River near its confluence with the Missouri River; was an important staging area for wagon trains westward in the 19th century