Sentence:  It was not just the confusion that unhappiness brings, it was not just the loneliness, it was the despair that accompanies all those emotions that turns unhappiness into utter <WSD>misery</WSD>. 
Meaning of the word marked with <WSD> tags:  Great (unhappiness); extreme (pain) of body or mind; (wretchedness); (distress); (woe).