Sentence:  In ſhort, no Inſtruments or Methods of <WSD>"Calumny</WSD>", and "Defamation" will be left unemployed to cruſh "the Man", who has the Courage to "oppoſe" the Errors, which "Avarice", and "Self-Intereſt" combine to eſtabliſh. 
Meaning of the word marked with <WSD> tags:  Falsifications or misrepresentations intended to disparage or discredit another.