Sentence:  His religious beliefs provide him with plausible explanations for many conditions which cause him great concern , and his religious faith makes possible fortitude , equanimity , and consolation , enabling him to endure colossal <WSD>misfortune</WSD> , fear , frustration , uncertainty , suffering , evil , and danger . 
Meaning of the word marked with <WSD> tags:  unnecessary and unforeseen trouble resulting from an unfortunate event