Spanish conquest of Nicaragua
... that within 100 years of the Spanish conquest of Nicaragua, the native population had been all but eliminated by a combination of newly-introduced disease, the slave trade, warfare, and mistreatment?
... that within 100 years of the <b id="mwAoo"><a href="./Spanish_conquest_of_Nicaragua" id="mwAos" rel="mw:WikiLink" title="Spanish conquest of Nicaragua">Spanish conquest of Nicaragua</a></b>, the native population had been all but eliminated by a combination of newly-introduced disease, the slave trade, warfare, and mistreatment?