Context: CREATE TABLE table_name_78 (against INTEGER, opposing_teams VARCHAR, venue VARCHAR, status VARCHAR)
Question: What is the lowest Against, when Venue is "Twickenham , London", when Status is "Six Nations", and when Opposing Teams is "France"?
Answer: SELECT MIN(against) FROM table_name_78 WHERE venue = "twickenham , london" AND status = "six nations" AND opposing_teams = "france"