derek-thomas/squad-v1.1-t5-question-generation huggingface dataset:
With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]

Question: What are antibiotics in chemical terms? Question: Besides semisytetic modifications, what advances in medicinal chemistry regarding antibacterials? Question: What type of antibiotics include penicilin? Question: What is included in the beta-lactam antibiotics? Question: What is penicillins produced by? Question: What are the type of antibiotics which are taken from still living things? Question: How are the slufonamides,quinolones, and oxazolidinones created? Question: What is the molecular weight loss of antibacterial compounds?
Antibiotics revolutionized medicine in the 20th century, and have together with vaccination led to the near eradication of diseases such as tuberculosis in the developed world. Their effectiveness and easy access led to overuse, especially in livestock raising, prompting bacteria to develop resistance. This has led to widespread problems with antimicrobial and antibiotic resistance, so much as to prompt the World Health Organization to classify antimicrobial resistance as a "serious threat [that] is no longer a prediction for the future, it is happening right now in every region of the world and has the potential to affect anyone, of any age, in any country".

Question: In which century were antibiotics first introduced? Question: In what century did antibiotics revolutionized medicine? Question: When did antibiotics revolutinzed medicine? Question: When were antibiotics created? Question: What other medicine worked along antibiotics to eradicate diseases like tuberculosis? Question: What is one disease that has been nearly eradicated thanks to vaccines and antibiotics? Question: What disease did antibiotics help eliminate? Question: What is one issue that can arise from overuse of antibiotics? Question: Who else uses antibiotics besides the medical industry? Question: What does there medicines do for livestock? Question: What happened when antibiotics was over used in livestock? Question: What is a common problem in antibiotic use? Question: Besides antimicrobial, what did the overused medicine cause? Question: What organization called antimicrobial resistance a 'serious threat?' Question: What organization classifies this as a current serious threat in the whole world?? Question: What organization stated that the world has this serious problem? Question: What regions in the world does this apply in? Question: What can be affected by issues resulting from overuse of antibiotics?
In empirical therapy, a patient has proven or suspected infection, but the responsible microorganism is not yet unidentified. While the microorgainsim is being identified the doctor will usually administer the best choice of antibiotic that will be most active against the likely cause of infection usually a broad spectrum antibiotic. Empirical therapy is usually initiated before the doctor knows the exact identification of microorgansim causing the infection as the identification process make take several days in the laboratory.

Question: What is one kind of therapy that may be used when a patience has an infection, but it has not been identified? Question: What happens in empirical therapy? Question: At what stage does a doctor begin empirical therapy? Question: What kinds of antibiotics are most commonly used for empirical therapy? Question: What happens when a doctor doesn't know the microorganism yet? Question: When is empirical started? Question: How long does the identification process take? Question: Where do doctors perform microorganism identification testing?
Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the antibiotics used, the microbial organisms targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity reactions or anaphylaxis. Safety profiles of newer drugs are often not as well established as for those that have a long history of use. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis. Common side-effects include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridium difficile. Antibacterials can also affect the vaginal flora, and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side-effects can result from interaction with other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid. Some scientists have hypothesized that the indiscriminate use of antibiotics alter the host microbiota and this has been associated with chronic disease.

Question: What are antibiotics screened for on mammals and humans? Question: Why are antibiotics checked before use? Question: What do antibiotics need approval for? Question: What besides the individual patient is targeted when antibiotics is being used? Question: Photodermatitis, nausea, allergic reactions and anaphylaxis are all what type of side effect? Question: What are two examples of minor side effects caused by some antibiotics? Question: Name some adverse effects? Question: Name some side-effects? Question: What causes diarrhea? Question: What can happen to vaginal flora? Question: What negative effects can antibiotics have on the vaginal area? Question: What can happen when antibiotics are used with other drugs? Question: What is one example of antibiotics that may have a possible side effect of tendon damage? Question: What is one possible serious side effect of over-using antibiotics? Question: What was altered during the hypothesis of indiscriminate use of antibiotics?
Exposure to antibiotics early in life is associated with increased body mass in humans and mouse models. Early life is a critical period for the establishment of the intestinal microbiota and for metabolic development. Mice exposed to subtherapeutic antibiotic treatment (STAT)– with either penicillin, vancomycin, penicillin and vancomycin, or chlortetracycline had altered composition of the gut microbiota as well as its metabolic capabilities. Moreover, research have shown that mice given low-dose penicillin (1 μg/g body weight) around birth and throughout the weaning process had an increased body mass and fat mass, accelerated growth, and increased hepatic expression of genes involved in adipogenesis, compared to controlled mice. In addition, penicillin in combination with a high-fat diet increased fasting insulin levels in mice. However, it is unclear whether or not antibiotics cause obesity in humans. Studies have found a correlation between early exposure of antibiotics (<6 months) and increased body mass (at 10 and 20 months). Another study found that the type of antibiotic exposure was also significant with the highest risk of being overweight in those given macrolides compared to penicillin and cephalosporin. Therefore, there is correlation between antibiotic exposure in early life and obesity in humans, but whether or not there is a causal relationship remains unclear. Although there is a correlation between antibiotic use in early life and obesity, the effect of antibiotics on obesity in humans needs to be weighed against the beneficial effects of clinically indicated treatment with antibiotics in infancy.

Question: What is one common result of using antibiotics from a young age? Question: What can happen if people are exposed to antibiotics at a young age? Question: When do intestinal microbiota develop? Question: What does STAT stand for? Question: What are some antibiotics can be used for STAT? Question: Do antibiotics cause obesity in humans? Question: Do antibiotics increase the chance of getting fat for humans? Question: Why do physicians use antibiotics on infants when the relationship has been proven?
The majority of studies indicate antibiotics do interfere with contraceptive pills, such as clinical studies that suggest the failure rate of contraceptive pills caused by antibiotics is very low (about 1%). In cases where antibacterials have been suggested to affect the efficiency of birth control pills, such as for the broad-spectrum antibacterial rifampicin, these cases may be due to an increase in the activities of hepatic liver enzymes' causing increased breakdown of the pill's active ingredients. Effects on the intestinal flora, which might result in reduced absorption of estrogens in the colon, have also been suggested, but such suggestions have been inconclusive and controversial. Clinicians have recommended that extra contraceptive measures be applied during therapies using antibacterials that are suspected to interact with oral contraceptives.

Question: Do antibiotics interact with birth control pills? Question: Do antibiotics mess with birth control pills? Question: What do antibiotics interfere with? Question: What percentage of birth control pill failure is attributed to antibiotics? Question: What percent is the  failure rate of contraceptive pills? Question: What is birth control failure rate due to antibiotics? Question: What are the potential effects on intestinal flora? Question: Whhat does intestinal flora reduce? Question: Have these potential effects been proven through testing? Question: What do physicians recommend to counteract this potential issue? Question: What should women do if they are using antibiotics and birth control pills? Question: In therapy, what does the antibacterial interact with?
Interactions between alcohol and certain antibiotics may occur and may cause side-effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side-effects. Therefore, potential risks of side-effects and effectiveness depend on the type of antibiotic administered. Despite the lack of a categorical counterindication, the belief that alcohol and antibiotics should never be mixed is widespread.

Question: What common drug can reduce antibiotic effectiveness? Question: What is one potential issue with drinking alcohol while taking antibiotics? Question: What can alcohol and certain antibiotics cause? Question: Do all antibiotics interact dangerously with alcohol? Question: What is unlikely to interfere with  with many common antibiotics? Question: Is it OK to drink alcohol while taking any antibiotic? Question: What type of antibiotic is most likely to be a problem with alcohol? Question: What belief should bever be mixed widespread? Question: Should alcohol be used while on antibiotics? Question: How common is the belief that alcohol and antibiotics should never be mixed?
Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.

Question: What is part of hje the make up of bacterial strains? Question: What can be absent from the bacterial genome? Question: What does some resistance come from? Question: When does the spread of antibacterial resistance frequently occurs/ Question: What method of spread can occur in antibacterial resistance? Question: What is exchanged between between bacterial strains or species via plasmids that have this resistance? Question: What do plasmids do in resistance?
Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were for a while well controlled. For example, emergent bacterial strains causing tuberculosis (TB) that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half a million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."

Question: What are strains that are resistant to antibiotics called sometimes? Question: What was a once almost controlled disease that is coming back do to resistance? Question: How many new infections of resistant TB are reported per year? Question: What is the acronym used to describe resistant TB?
Inappropriate antibiotic treatment and overuse of antibiotics have contributed to the emergence of antibiotic-resistant bacteria. Self prescription of antibiotics is an example of misuse. Many antibiotics are frequently prescribed to treat symptoms or diseases that do not respond to antibiotics or that are likely to resolve without treatment. Also, incorrect or suboptimal antibiotics are prescribed for certain bacterial infections. The overuse of antibiotics, like penicillin and erythromycin, has been associated with emerging antibiotic resistance since the 1950s. Widespread usage of antibiotics in hospitals has also been associated with increases in bacterial strains and species that no longer respond to treatment with the most common antibiotics.

Question: What are the two biggest reasons for resistance? Question: What is a common method of misuse? Question: What is an example of bad treatment causing resistance?
Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of the patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold. One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics.

Question: What is a way of improperly using antibiotics for those traveling? Question: What can happen if a doctor doesn't prescribe to a person's weight and prior use? Question: What are 3 other common forms of bad antibiotic practices? Question: What happens when a cold is treated with antibiotics? Question: What do doctors usually do when a patient seems to want antibiotics even though they may not be right?
Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicrobial resistance, and is coordinated by the US Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and the National Institutes of Health (NIH), as well as other US agencies. An NGO campaign group is Keep Antibiotics Working. In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children.

Question: What is the name of a US government agency tasked with trying to stop improper use of antibiotics? Question: Which agencies control this task force? Question: When did the French start going after overuse of antibiotics?
The emergence of antibiotic resistance has prompted restrictions on their use in the UK in 1970 (Swann report 1969), and the EU has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (e.g., The American Society for Microbiology (ASM), American Public Health Association (APHA) and the American Medical Association (AMA)) have called for restrictions on antibiotic use in food animal production and an end to all nontherapeutic uses.[citation needed] However, commonly there are delays in regulatory and legislative actions to limit the use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including the American Holistic Nurses' Association, the American Medical Association, and the American Public Health Association (APHA).

Question: What report caused the UK to worry about resistance? Question: When did the EU ban antibiotics for speeding up growth? Question: What 3 US organizations have called for the banning of antibiotics in the production of food animals? Question: Name two US bills that want to ban antibiotics in food production? Question: What 3 medical associations supported the bills?
There has been extensive use of antibiotics in animal husbandry. In the United States, the question of emergence of antibiotic-resistant bacterial strains due to use of antibiotics in livestock was raised by the US Food and Drug Administration (FDA) in 1977. In March 2012, the United States District Court for the Southern District of New York, ruling in an action brought by the Natural Resources Defense Council and others, ordered the FDA to revoke approvals for the use of antibiotics in livestock, which violated FDA regulations.

Question: What besides sick people are antibiotics used for? Question: When was resistance first discussed as a problem in the raising of farm animals? Question: When did a district court order the FDA to stop approving antibiotics in animals?
Before the early 20th century, treatments for infections were based primarily on medicinal folklore. Mixtures with antimicrobial properties that were used in treatments of infections were described over 2000 years ago. Many ancient cultures, including the ancient Egyptians and ancient Greeks, used specially selected mold and plant materials and extracts to treat infections. More recent observations made in the laboratory of antibiosis between microorganisms led to the discovery of natural antibacterials produced by microorganisms. Louis Pasteur observed, "if we could intervene in the antagonism observed between some bacteria, it would offer perhaps the greatest hopes for therapeutics". The term 'antibiosis', meaning "against life", was introduced by the French bacteriologist Jean Paul Vuillemin as a descriptive name of the phenomenon exhibited by these early antibacterial drugs. Antibiosis was first described in 1877 in bacteria when Louis Pasteur and Robert Koch observed that an airborne bacillus could inhibit the growth of Bacillus anthracis. These drugs were later renamed antibiotics by Selman Waksman, an American microbiologist, in 1942. Synthetic antibiotic chemotherapy as a science and development of antibacterials began in Germany with Paul Ehrlich in the late 1880s. Ehrlich noted certain dyes would color human, animal, or bacterial cells, whereas others did not. He then proposed the idea that it might be possible to create chemicals that would act as a selective drug that would bind to and kill bacteria without harming the human host. After screening hundreds of dyes against various organisms, in 1907, he discovered a medicinally useful drug, the synthetic antibacterial salvarsan now called arsphenamine.

Question: What methods did people use before antibiotics to treat infections? Question: When were some kinds of antimicrobials first used? Question: What type of things did Egyptians and Greeks use? Question: What does antibiosis mean? Question: Who came up with the term antibiosis?
The effects of some types of mold on infection had been noticed many times over the course of history (see: History of penicillin). In 1928, Alexander Fleming noticed the same effect in a Petri dish, where a number of disease-causing bacteria were killed by a fungus of the genus Penicillium. Fleming postulated that the effect is mediated by an antibacterial compound he named penicillin, and that its antibacterial properties could be exploited for chemotherapy. He initially characterized some of its biological properties, and attempted to use a crude preparation to treat some infections, but he was unable to pursue its further development without the aid of trained chemists.

Question: What type of organism has been reported to have worked on infections? Question: Who noticed in a lab the antibacterial characteristics of mold? Question: What mold did Fleming notice had antibacterial properties? Question: What did Fleming initially think a good use would be for it?
The first sulfonamide and first commercially available antibacterial, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany. Domagk received the 1939 Nobel Prize for Medicine for his efforts. Prontosil had a relatively broad effect against Gram-positive cocci, but not against enterobacteria. Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.

Question: What was the first available antibiotic? Question: Who led the team that came up with Prontosil? Question: What company developed Prontosil? Question: What prize did Domagk get for his work?