derek-thomas/squad-v1.1-t5-question-generation huggingface dataset:
In many non-US western countries a 'fourth hurdle' of cost effectiveness analysis has developed before new technologies can be provided. This focuses on the efficiency (in terms of the cost per QALY) of the technologies in question rather than their efficacy. In England and Wales NICE decides whether and in what circumstances drugs and technologies will be made available by the NHS, whilst similar arrangements exist with the Scottish Medicines Consortium in Scotland, and the Pharmaceutical Benefits Advisory Committee in Australia. A product must pass the threshold for cost-effectiveness if it is to be approved. Treatments must represent 'value for money' and a net benefit to society.

Question: NICE decides the availability of drugs in which two countries? Question: What is the name of the organization in Scotland that decides the availability of drugs? Question: What threshold must a drug pass before it is approved?
The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in the United States in 2013 were Abilify ($6.3 billion,) Nexium ($6 billion) and Humira ($5.4 billion). The best-selling drug ever, Lipitor, averaged $13 billion annually and netted $141 billion total over its lifetime before Pfizer's patent expired in November 2011.

Question: How much money did the top ten bestselling drugs make in 2013? Question: What was the name of the top-selling anti-inflammatory drug in 2013? Question: What was the bestselling drug in history? Question: How much money did Lipitor make before the patent expired? Question: In what year did Pfizer's patent over Lipitor expire?
Depending on a number of considerations, a company may apply for and be granted a patent for the drug, or the process of producing the drug, granting exclusivity rights typically for about 20 years. However, only after rigorous study and testing, which takes 10 to 15 years on average, will governmental authorities grant permission for the company to market and sell the drug. Patent protection enables the owner of the patent to recover the costs of research and development through high profit margins for the branded drug. When the patent protection for the drug expires, a generic drug is usually developed and sold by a competing company. The development and approval of generics is less expensive, allowing them to be sold at a lower price. Often the owner of the branded drug will introduce a generic version before the patent expires in order to get a head start in the generic market. Restructuring has therefore become routine, driven by the patent expiration of products launched during the industry's "golden era" in the 1990s and companies' failure to develop sufficient new blockbuster products to replace lost revenues.

Question: How long do drug exclusivity rights usually last? Question: Governments grant permission to market drugs after how many years? Question: What enables a drug's owner to recover R&D costs? Question: What kind of drug is produced by competitors once a patent expires? Question: What decade was the pharmaceutical industry's "golden era"?
In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.

Question: The safety and efficacy of new drugs must be approved by what organization in the US? Question: What type of filing is used before beginning human trials? Question: How many phases of human trials may be done after IND approval? Question: What type of application is filed after completing three phases of human trials? Question: What type of risk assessment results in approving the drug to go on the market?
Advertising is common in healthcare journals as well as through more mainstream media routes. In some countries, notably the US, they are allowed to advertise directly to the general public. Pharmaceutical companies generally employ sales people (often called 'drug reps' or, an older term, 'detail men') to market directly and personally to physicians and other healthcare providers. In some countries, notably the US, pharmaceutical companies also employ lobbyists to influence politicians. Marketing of prescription drugs in the US is regulated by the federal Prescription Drug Marketing Act of 1987.

Question: "Drug reps" are usually hired by what type of firms? Question: Who do drug reps market to? Question: What law regulates drug marketing in the US?
There has been increasing controversy surrounding pharmaceutical marketing and influence. There have been accusations and findings of influence on doctors and other health professionals through drug reps, including the constant provision of marketing 'gifts' and biased information to health professionals; highly prevalent advertising in journals and conferences; funding independent healthcare organizations and health promotion campaigns; lobbying physicians and politicians (more than any other industry in the US); sponsorship of medical schools or nurse training; sponsorship of continuing educational events, with influence on the curriculum; and hiring physicians as paid consultants on medical advisory boards.

Question: Drug reps have been accused of giving what to health professionals? Question: What publications can drug ads be commonly found? Question: Drug marketers have hired who as paid consultants?
The rivalries between the Arab tribes had caused unrest in the provinces outside Syria, most notably in the Second Muslim Civil War of 680–692 CE and the Berber Revolt of 740–743 CE. During the Second Civil War, leadership of the Umayyad clan shifted from the Sufyanid branch of the family to the Marwanid branch. As the constant campaigning exhausted the resources and manpower of the state, the Umayyads, weakened by the Third Muslim Civil War of 744–747 CE, were finally toppled by the Abbasid Revolution in 750 CE/132 AH. A branch of the family fled across North Africa to Al-Andalus, where they established the Caliphate of Córdoba, which lasted until 1031 before falling due to the Fitna of al-Ándalus.

Question: In what year CE did the Second Muslim Civil War end? Question: During what period did the Berber Revolt occur? Question: What branch took over Umayyad leadership during the Second Civil War?
Ali was assassinated in 661 by a Kharijite partisan. Six months later in the same year, in the interest of peace, Hasan ibn Ali, highly regarded for his wisdom and as a peacemaker, and the Second Imam for the Shias, and the grandson of Muhammad, made a peace treaty with Muawiyah I. In the Hasan-Muawiya treaty, Hasan ibn Ali handed over power to Muawiya on the condition that he be just to the people and keep them safe and secure, and after his death he not establish a dynasty. This brought to an end the era of the Rightly Guided Caliphs for the Sunnis, and Hasan ibn Ali was also the last Imam for the Shias to be a Caliph. Following this, Mu'awiyah broke the conditions of the agreement and began the Umayyad dynasty, with its capital in Damascus.

Question: In what year was Ali killed? Question: Who killed Ali? Question: Who made peace with Muawiyah I? Question: Where was the capital of the Umayyad dynasty?
At the time, the Umayyad taxation and administrative practice were perceived as unjust by some Muslims. The Christian and Jewish population had still autonomy; their judicial matters were dealt with in accordance with their own laws and by their own religious heads or their appointees, although they did pay a poll tax for policing to the central state. Muhammad had stated explicitly during his lifetime that abrahamic religious groups (still a majority in times of the Umayyad Caliphate), should be allowed to practice their own religion, provided that they paid the jizya taxation. The welfare state of both the Muslim and the non-Muslim poor started by Umar ibn al Khattab had also continued. Muawiya's wife Maysum (Yazid's mother) was also a Christian. The relations between the Muslims and the Christians in the state were stable in this time. The Umayyads were involved in frequent battles with the Christian Byzantines without being concerned with protecting themselves in Syria, which had remained largely Christian like many other parts of the empire. Prominent positions were held by Christians, some of whom belonged to families that had served in Byzantine governments. The employment of Christians was part of a broader policy of religious assimilation that was necessitated by the presence of large Christian populations in the conquered provinces, as in Syria. This policy also boosted Muawiya's popularity and solidified Syria as his power base.

Question: What form of tax were Christians required to pay? Question: Who was the mother of Yazid? Question: What was Maysum's religion?
The Umayyad Caliphate (Arabic: الخلافة الأموية‎, trans. Al-Khilāfat al-ʾumawiyya) was the second of the four major Islamic caliphates established after the death of Muhammad. This caliphate was centered on the Umayyad dynasty (Arabic: الأمويون‎, al-ʾUmawiyyūn, or بنو أمية, Banū ʾUmayya, "Sons of Umayya"), hailing from Mecca. The Umayyad family had first come to power under the third caliph, Uthman ibn Affan (r. 644–656), but the Umayyad regime was founded by Muawiya ibn Abi Sufyan, long-time governor of Syria, after the end of the First Muslim Civil War in 661 CE/41 AH. Syria remained the Umayyads' main power base thereafter, and Damascus was their capital. The Umayyads continued the Muslim conquests, incorporating the Caucasus, Transoxiana, Sindh, the Maghreb and the Iberian Peninsula (Al-Andalus) into the Muslim world. At its greatest extent, the Umayyad Caliphate covered 15 million km2 (5.79 million square miles), making it the largest empire (in terms of area - not in terms of population) the world had yet seen, and the fifth largest ever to exist.

Question: How many major Islamic caliphates existed after Muhammad's death? Question: Who was the third caliph? Question: Who founded the Umayyad regime? Question: How many million square miles was the Umayyad caliphate at its largest size?
Most historians[who?] consider Caliph Muawiyah (661–80) to have been the second ruler of the Umayyad dynasty, even though he was the first to assert the Umayyads' right to rule on a dynastic principle. It was really the caliphate of Uthman Ibn Affan (644–656), a member of Umayyad clan himself, that witnessed the revival and then the ascendancy of the Umayyad clan to the corridors of power. Uthman placed some of the trusted members of his clan at prominent and strong positions throughout the state. Most notable was the appointment of Marwan ibn al-Hakam, Uthman's first cousin, as his top advisor, which created a stir among the Hashimite companions of Muhammad, as Marwan along with his father Al-Hakam ibn Abi al-'As had been permanently exiled from Medina by Muhammad during his lifetime. Uthman also appointed as governor of Kufa his half-brother, Walid ibn Uqba, who was accused by Hashmites of leading prayer while under the influence of alcohol. Uthman also consolidated Muawiyah's governorship of Syria by granting him control over a larger area and appointed his foster brother Abdullah ibn Saad as the Governor of Egypt. However, since Uthman never named an heir, he cannot be considered the founder of a dynasty.

Question: When did Muawiyah become caliph? Question: When did the caliphate of Uthman Ibn Affan end? Question: Who was the son of Al-Hakam ibn Abi al-'As?
Following the death of Husayn, Ibn al-Zubayr, although remaining in Mecca, was associated with two opposition movements, one centered in Medina and the other around Kharijites in Basra and Arabia. Because Medina had been home to Muhammad and his family, including Husayn, word of his death and the imprisonment of his family led to a large opposition movement. In 683, Yazid dispatched an army to subdue both movements. The army suppressed the Medinese opposition at the Battle of al-Harrah. The Grand Mosque in Medina was severely damaged and widespread pillaging caused deep-seated dissent. Yazid's army continued on and laid siege to Mecca. At some point during the siege, the Kaaba was badly damaged in a fire. The destruction of the Kaaba and Grand Mosque became a major cause for censure of the Umayyads in later histories of the period.

Question: What opposition movement was based in Arabia and Basra? Question: Who sent an army in 683 to stop the opposition movements? Question: In what battle was the Medinese opposition movement defeated? Question: Where is the Kaaba located?
According to tradition, the Umayyad family (also known as the Banu Abd-Shams) and Muhammad both descended from a common ancestor, Abd Manaf ibn Qusai, and they originally came from the city of Mecca. Muhammad descended from Abd Manāf via his son Hashim, while the Umayyads descended from Abd Manaf via a different son, Abd-Shams, whose son was Umayya. The two families are therefore considered to be different clans (those of Hashim and of Umayya, respectively) of the same tribe (that of the Quraish). However Muslim Shia historians suspect that Umayya was an adopted son of Abd Shams so he was not a blood relative of Abd Manaf ibn Qusai. Umayya was later discarded from the noble family. Sunni historians disagree with this and view Shia claims as nothing more than outright polemics due to their hostility to the Umayyad family in general. They point to the fact that the grand sons of Uthman, Zaid bin amr bin uthman bin affan and Abdullah bin Amr bin Uthman got married to the Sukaina and Fatima the daughters of Hussein son of Ali to show closeness of Banu hashem and Bani Ummayah.

Question: What is another term for the Umayyads? Question: Traditionally, who did the Umayyads and Muhammad both descend from? Question: From what city did the Umayyads originate? Question: What son of Abd-Shams was the ancestor of the Umayyads?
Following this battle, Ali fought a battle against Muawiyah, known as the Battle of Siffin. The battle was stopped before either side had achieved victory, and the two parties agreed to arbitrate their dispute. After the battle Amr ibn al-As was appointed by Muawiyah as an arbitrator, and Ali appointed Abu Musa Ashaari. Seven months later, in February 658, the two arbitrators met at Adhruh, about 10 miles north west of Maan in Jordon. Amr ibn al-As convinced Abu Musa Ashaari that both Ali and Muawiyah should step down and a new Caliph be elected. Ali and his supporters were stunned by the decision which had lowered the Caliph to the status of the rebellious Muawiyah I. Ali was therefore outwitted by Muawiyah and Amr. Ali refused to accept the verdict and found himself technically in breach of his pledge to abide by the arbitration. This put Ali in a weak position even amongst his own supporters. The most vociferous opponents in Ali's camp were the very same people who had forced Ali into the ceasefire. They broke away from Ali's force, rallying under the slogan, "arbitration belongs to God alone." This group came to be known as the Kharijites ("those who leave"). In 659 Ali's forces and the Kharijites met in the Battle of Nahrawan. Although Ali won the battle, the constant conflict had begun to affect his standing, and in the following years some Syrians seem to have acclaimed Muawiyah as a rival caliph.

Question: Where did Muawiyah fight Ali? Question: Who was appointed arbitrator by Ali? Question: What did the term Kharjites mean? Question: In what battle did Ali fight the Kharjites?
The Quran and Muhammad talked about racial equality and justice as in The Farewell Sermon. Tribal and nationalistic differences were discouraged. But after Muhammad's passing, the old tribal differences between the Arabs started to resurface. Following the Roman–Persian Wars and the Byzantine–Sassanid Wars, deep rooted differences between Iraq, formally under the Persian Sassanid Empire, and Syria, formally under the Byzantine Empire, also existed. Each wanted the capital of the newly established Islamic State to be in their area. Previously, the second caliph Umar was very firm on the governors and his spies kept an eye on them. If he felt that a governor or a commander was becoming attracted to wealth, he had him removed from his position.

Question: Who controlled Iraq before the Arabs? Question: Who ruled Syria before it was conquered by the followers of Muhammad? Question: Who was the second caliph?
While the Umayyads and the Hashimites may have had bitterness between the two clans before Muhammad, the rivalry turned into a severe case of tribal animosity after the Battle of Badr. The battle saw three top leaders of the Umayyad clan (Utba ibn Rabi'ah, Walid ibn Utbah and Shaybah) killed by Hashimites (Ali, Hamza ibn ‘Abd al-Muttalib and Ubaydah ibn al-Harith) in a three-on-three melee. This fueled the opposition of Abu Sufyan ibn Harb, the grandson of Umayya, to Muhammad and to Islam. Abu Sufyan sought to exterminate the adherents of the new religion by waging another battle with Muslims based in Medina only a year after the Battle of Badr. He did this to avenge the defeat at Badr. The Battle of Uhud is generally believed by scholars to be the first defeat for the Muslims, as they had incurred greater losses than the Meccans. After the battle, Abu Sufyan's wife Hind, who was also the daughter of Utba ibn Rabi'ah, is reported to have cut open the corpse of Hamza, taking out his liver which she then attempted to eat. Within five years after his defeat in the Battle of Uhud, however, Muhammad took control of Mecca and announced a general amnesty for all. Abu Sufyan and his wife Hind embraced Islam on the eve of the conquest of Mecca, as did their son (the future caliph Muawiyah I).

Question: Who did the Umayyads fight in the Battle of Badr? Question: How many top leaders of the Umayyads were killed in the Battle of Badr? Question: What do historians see as the first military defeat of Islam? Question: Who was the spouse of Abu Sufyan? Question: Who was the son of Abu Sufyan?
Umar is honored for his attempt to resolve the fiscal problems attendant upon conversion to Islam. During the Umayyad period, the majority of people living within the caliphate were not Muslim, but Christian, Jewish, Zoroastrian, or members of other small groups. These religious communities were not forced to convert to Islam, but were subject to a tax (jizyah) which was not imposed upon Muslims. This situation may actually have made widespread conversion to Islam undesirable from the point of view of state revenue, and there are reports that provincial governors actively discouraged such conversions. It is not clear how Umar attempted to resolve this situation, but the sources portray him as having insisted on like treatment of Arab and non-Arab (mawali) Muslims, and on the removal of obstacles to the conversion of non-Arabs to Islam.

Question: Along with Christians and Jews, what was a major non-Muslim religious group under the Umayyads? Question: What tax did non-Muslims pay in the Umayyad period? Question: What was another term for Muslims who were not Arab?
After the assassination of Uthman in 656, Ali, a member of the Quraysh tribe and the cousin and son-in-law of Muhammad, was elected as the caliph. He soon met with resistance from several factions, owing to his relative political inexperience. Ali moved his capital from Medina to Kufa. The resulting conflict, which lasted from 656 until 661, is known as the First Fitna ("civil war"). Muawiyah I, the governor of Syria, a relative of Uthman ibn al-Affan and Marwan I, wanted the culprits arrested. Marwan I manipulated everyone and created conflict. Aisha, the wife of Muhammad, and Talhah and Al-Zubayr, two of the companions of Muhammad, went to Basra to tell Ali to arrest the culprits who murdered Uthman. Marwan I and other people who wanted conflict manipulated everyone to fight. The two sides clashed at the Battle of the Camel in 656, where Ali won a decisive victory.

Question: When did Uthman die? Question: What tribe did Ali belong to? Question: Along with being his cousin, what relationship did Ali have to Muhammad? Question: Where was the capital before Ali changed it? Question: What does Fitna mean?
Early Muslim armies stayed in encampments away from cities because Umar feared that they might get attracted to wealth and luxury. In the process, they might turn away from the worship of God and start accumulating wealth and establishing dynasties. When Uthman ibn al-Affan became very old, Marwan I, a relative of Muawiyah I, slipped into the vacuum, became his secretary, slowly assumed more control and relaxed some of these restrictions. Marwan I had previously been excluded from positions of responsibility. In 656, Muhammad ibn Abi Bakr, the son of Abu Bakr, the adopted son of Ali ibn Abi Talib, and the great grandfather of Ja'far al-Sadiq, showed some Egyptians the house of Uthman ibn al-Affan. Later the Egyptians ended up killing Uthman ibn al-Affan.

Question: Who was Marwan I related to? Question: Who adopted Muhammad ibn Abi Bakr? Question: Who was the great grandson of Muhammad ibn Ali Bakr? Question: What group murdered Uthman ibn al-Affan?
In 680 Ibn al-Zubayr fled Medina for Mecca. Hearing about Husayn's opposition to Yazid I, the people of Kufa sent to Husayn asking him to take over with their support. Al-Husayn sent his cousin Muslim bin Agail to verify if they would rally behind him. When the news reached Yazid I, he sent Ubayd-Allah bin Ziyad, ruler of Basrah, with the instruction to prevent the people of Kufa rallying behind Al-Husayn. Ubayd-Allah bin Ziyad managed to disperse the crowd that gathered around Muslim bin Agail and captured him. Realizing Ubayd-Allah bin Ziyad had been instructed to prevent Husayn from establishing support in Kufa, Muslim bin Agail requested a message to be sent to Husayn to prevent his immigration to Kufa. The request was denied and Ubayd-Allah bin Ziyad killed Muslim bin Agail. While Ibn al-Zubayr would stay in Mecca until his death, Husayn decided to travel on to Kufa with his family, unaware of the lack of support there. Husayn and his family were intercepted by Yazid I's forces led by Amru bin Saad, Shamar bin Thi Al-Joshan, and Hussain bin Tamim, who fought Al-Husayn and his male family members until they were killed. There were 200 people in Husayn's caravan, many of whom were women, including his sisters, wives, daughters and their children. The women and children from Husayn's camp were taken as prisoners of war and led back to Damascus to be presented to Yazid I. They remained imprisoned until public opinion turned against him as word of Husayn's death and his family's capture spread. They were then granted passage back to Medina. The sole adult male survivor from the caravan was Ali ibn Husayn who was with fever too ill to fight when the caravan was attacked.

Question: Where did Ibn al-Zubayr flee to in 680? Question: Who did Al-Husayn send to Kufa? Question: What did Ubayd-Allah bin Ziyad rule? Question: Who did Ubayd-Allah bin Ziyad murder?