Question: milroy disease hello , my daughter has lymph edema her both legs and left hand is swelling , this problem started when she was of 3 months now she is  16 months , her swelling is growing day by day , im clue less what to do and what kind of treatment i should do plz help and suggest us

Reference:
 Milroy disease Hereditary lymphedema Congenital hereditary lymphedema Early onset lymphedema Hereditary lymphedema Congenital hereditary lymphedema Early onset lymphedema Hereditary lymphedema 1 Primary congenital lymphedema Nonne-Milroy syndrome Nonne-Milroy disease Milroy's disease Nonne’s syndrome Congenital primary lymphedema Hereditary lymphedema type I Nonne-Milroy lymphedema See More Summary Milroy disease is a lymphatic disease that causes swelling (lymphedema) in the lower legs and feet. Lymphedema is usually present at birth or develops in infancy. It typically occurs on both sides of the body and can worsen over time. Other symptoms may include accumulation of fluid in the scrotum in males (hydrocele), upslanting toenails, deep creases in the toes, wart-like growths, prominent leg veins, and/or cellulitis. Milroy disease is sometimes caused by changes ( mutations ) in the FLT4 gene and is inherited in an autosomal dominant manner. In many cases, the cause remains unknown. [1] Treatment may include lymphedema therapy to improve function and alleviate symptoms. [2] Symptoms The most common symptom of Milroy disease is build-up of fluids ( lymphedema) in the lower limbs, which is usually present from birth or before birth. [2] However, the degree and distribution of swelling varies among affected people. [3] It sometimes progresses, but may improve in some cases. Other signs and symptoms may include hydrocele and/or urethral abnormalities in males; prominent veins; upslanting toenails; papillomatosis (development of wart-like growths); and cellulitis. Cellulitis may cause additional swelling. [2] This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom. Showing of Medical Terms Other Names Learn More: HPO ID Percent of people who have these symptoms is not available through HPO Abnormality of the amniotic fluid 0001560 Abnormality of the nail 0001597 Autosomal dominant inheritance 0000006 Congenital onset Symptoms present at birth 0003577 Hemangioma Strawberry mark 0001028 Hydrocele testis 0000034 Hyperkeratosis over edematous areas 0007448 Hypoplasia of lymphatic vessels Underdeveloped lymphatic vessels 0003759 Nonimmune hydrops fetalis 0001790 Predominantly lower limb lymphedema 0003550 Showing of Inheritance Milroy disease is inherited in an autosomal dominant manner. This means that having one changed ( mutated ) copy of the responsible gene in each cell is enough to cause symptoms of the condition. When a person with an autosomal dominant condition has children, each child has a 50% (1 in 2) chance to inherit the mutated copy of the gene. Most people with Milroy disease have an affected parent, but some cases are due to new mutations that occur for the first time in the affected person. About 10-15% of people with a mutation in the responsible gene do not develop features of the condition. This phenomenon is called reduced penetrance . [2] Diagnosis Making a diagnosis for a genetic or rare disease can often be challenging. Healthcare professionals typically look at a person's medical history, symptoms, physical exam, and laboratory test results in order to make a diagnosis. The following resources provide information relating to diagnosis and testing for this condition. If you have questions about getting a diagnosis, you should contact a healthcare professional. Testing Resources The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional. Treatment Management is typically conservative and usually successful in most people. [3] The goal of treatment is to reduce swelling and prevent complications. Management of lymphedema should be guided by a lymphedema therapist. Complete decongestive therapy (CDT) may be used for manual lymph drainage combined with compression bandaging, skin care, exercise, and well-fitted compression garments. [4] Some improvement is usually possible using these methods. [2] Various surgical techniques (to reduce swelling by creating new pathways for lymphatic fluid to flow) have been tried, but with limited success. [4] To prevent cellulitis, foot infections (such as athlete's foot) should be treated promptly and prevented, and prophylactic antibiotics may be needed in recurrent cases. [2] [3] When possible, people with Milroy disease should try to avoid w Prognosis The symptoms and severity of Milroy disease can vary among affected people (even within the same family), so the long-term effects of the condition may be difficult to predict. [2] Swelling varies in degree and distribution, and can be disabling and disfiguring. [3] For some people the outlook depends on how chronic the lymphedema is, as well as whether complications arise. [4] However, Milroy disease is rarely associated with significant complications. [3] The degree of edema sometimes progresses, but in some cases can improve (particularly in early years). [2] Complications of lymphedema may include recurrent bouts of cellulitis and/or lymphangitis, bacterial and fungal infections, deep venous thrombosis, functional impairment, cosmetic embarrassment, and amputation. Complications following surgery are common. [4] It has also been reported that people with chronic lymphedema for many years may have a significantly higher risk to develop lymphangiosarcoma (a type of angiosarcoma). This type of tumor is highly aggressive and has a very poor prognosis . [4] Find a Specialist If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments. If you can't find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care. You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists. Healthcare Resources To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by the American College of Medical Genetics and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference. 

Answer: There is currently no cure for Milroy disease. Conservative management is usually successful in most people. Management of lymphedema should be guided by a lymphedema therapist. Some improvement is possible with the use of properly fitted compression hosiery or bandaging and well fitting, supportive shoes. Good skin care is essential. Decongestive physiotherapy, which combines compression bandaging, manual lymphatic drainage (a specialized massage technique), exercise, breathing exercises, dietary measures and skin care, is the standard of care for primary lymphedema.  People with recurrent cellulitis may benefit from prophylactic antibiotics  Surgical intervention is considered a last option when other medical management fails.  When possible, people with Milroy disease should avoid wounds to swollen areas (because of their reduced resistance to infection,) long periods of immobility, prolonged standing, elevation of the affected limb, and calcium channel-blocking drugs that can cause increased leg swelling in some people.