ARCHIVESHISTORIQUES
DELACOMMISSION
COLLECTION RELIEEDES
DOCUMENTS "COM"
COM(81)604
Vol.1981/0183

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COMMISSION OFTHEEUROPEAN COMMUNITIES
COM(81)604 final
Brussels.30October1981
Draft
,COUNCILDECISION
ontheconclusionoftheAgreementbetweentheEuropeanEconomic
Community andSwitzerland onaconcertedactionprojectinthe
fieldofthedetectionofthetendencytothrombosis
/.*N/»-l
(submittedtotheCouncilbythe/Commission )
C0M(81)604final

C-erwv(go^
.COMMUNICATION FROMTHECOMMISSION TOTHECOUNCIL -
Subject:Agreement betweentheEuropeanEconomicCommunity and
Switzerland onaconcertedprojectrelatingtothedetection
ofthetendencytothrombosis
Asecondresearchprogrammeinthefieldofmedicalandpublichealth
researchconsistingof,fourmultiannual concertedactionprojects,oneof
whichconcernsthedetectionofthetendencytothrombosis,wasadoptedby
theCounciIon18March1980^.
Article6oftheaforesaidDecisionprovidesfortheconclusion ofinter­
nationalagreements betweentheCommunity andnon-member Statespartici­
patinginCOST(EuropeanCo-operation inthefieldofScientific andTech­
nicalResearch)withaviewtoassociating themwiththesaidprojects.
Underthetermsofthesameprovision,theCommission wasauthorized to
enterintonegotiations tothatend.
On16July1981Switzerland expresseditswillingness toparticipate inthe
concertedactionprojectrelatingtothedetectionofthetendencyto
thrombosis .Thenegotiations withSwitzerland resultedinthedraftagree­
mentappendedtotheattacheddraftCounciIdecision.
Thisagreementprovidesthat: •
-thepersonresponsible forcoordinating theSwissnationalcontribution
totheconcertedprojectshallbeamemberoftheConcertedAction _
Committee ontheDetectionoftheTendencytoThrombosis .
-theSwissfinancialcontribution totheco-ordination costsshallbe
38000ECUfortheperiodreferredtoinArticle 1oftheagreement.
TheCommission requeststheCounciltoadoptthedraftdecisionconcluding
theaforesaid agreement.
OJNoL78of25March1980,p.24.

DRAFTCOUNCILDECISION
ontheconclusionoftheAgreementbetweentheEuropeanEconomicCommunity
andSwitzerland onaconcertedactionprojectinthefieldofthedetection
ofthetendencytothrombosis
THECOUNCILOFTHEEUROPEAN COMMUNITIES,
HavingregardtotheTreatyestablishing theEuropeanEconomicCommunity,
HavingregardtoCouncilDecision80/344/EECof18March1980adopting asecond
researchprogrammeinthefieldofmedicalandpublichealthresearch,
consistingoffourmultiannual concertedactionprojects^,andinpart­
icularArticle6(1)thereof,
HavingregardtothedraftDecisionsubmittedbytheCommission,
Whereas,pursuanttoArticle6(2)ofDecision80/344/EEC,theCommission
hasnegotiated anAgreementwithSwtzerlandwithaviewtoassociatingit
withtheconcertedactionprojectinthefieldofthedetectionofthe
tendencytothrombosis;
WhereasthatAgreementshouldbeapproved,
HASDECIDED ASFOLLOWS:
Article 1
TheAgreementbetweentheEuropeanEconomicCommunity onaconcerted
actionprojectinthefieldofthedetectionofthetendencytothrombosis
isherebyapprovedonbehalfoftheCommunity.
ThetextoftheAgreementisannexedtothisDecision.
10JNoL78,25.3.1980,p.25

Artide2
ThePresidentoftheCouncilisherebyauthorizedtodesignatethe
personsempoweredtosigntheAgreementinordertobindtheCommunity
DoneatBrussels.....
FortheCouncil
ThePresident

DRAFTAGREEMENT
betweentheEuropeanEconomicCommunity andSwitzerland onaconcerted
actionprojectinthe'fieldcfthedetectionofthetendencytothrombosis
THEEUROPEAN EÇONOMIC COMMUNITY
and ■
SWITZERLAND, V
WhereasaEuropeanconcertedresearchactionprojectinthefieldofthe
detectionofthetendencytothrombosisislikelytocontributeeffctively
toensuringanoptimumlevelofhealthinindividuals andinsociety;
Whereas,byitsDecisionof18March1980,theCounciloftheEuropean
Communities adoptedasecondresearchprogrammeinthefieldofmedicaland
publichealthresearchconsistingoffourmultiannual concertedprojects,
oneofwhichrelatestothedetectionofthetendencytothrombosis;
Whereas,theMemberStatesoftheCommunity andSwitzerland,hereinafter
referredtoas"theStates",intend,subjecttotherulesandprocedures
applicable totheirnationalprogrammes,tocarryouttheresearchdescribed
inAnnexAandarepreparedtointegrate suchresearchintoaprocessof
co-ordination whichtheyconsiderwillbeofmutualbenefit;
•" . .11
Whereastheimplementation oftheresearchcoveredbytheconcertedaction
projectwillrequirea,financialcontribution ofapproximately 10million ■
ECUfromtheStates,
HAVEAGREEDASFOLLOWS:

Article 1
TheCommunityandSwitzerland,hereinafterreferredtoas"thecontract­
ingparties",shallparticipateforaperiodextendinguntil31May1984
inaconcertedactionprojectinthefieldofthedetectionofthetend­
encytothrombosiSo
Thisprojectshallconsistinco-ordinating theCommunityconcertedaction
programmewiththecorresponding programmeofSwitzerland.Th^programmes
coveredbythisAgreementarelistedinAnnexA.-
TheStatesshallremainentirelyresponsiblefortheresearchexecutedby
theirnationalinstitutions orbodies.
.Article2
TheCommissionoftheEuropeanCommunitiesshallberesponsibleforthe
co-ordination .
Itshallbeassistedinthistaskbyaprojectleader.
Article3
Inordertofacilitatetheexecutionoftheproject,theConcertedAction
CommitteeontheDetectionoftheTendencytoThrombosis,hereinafter
referredtoas"theCommittee",setupbytheDecisionoftheCouncilof
theEuropeanCommunities of18March1980,shallbeenlargedtoinclude
Switzerland .
Thesecretariat oftheCommitteeshallbeprovidedbytheCommission.
Thetermsof.referenceandthecomposition oftheCommitteeshallbeas
:setoutinAnnexB.

Article4
Themaximumfinancialcontribution bythecontractingpartiestotheco­
ordination costsshallbe:
-616000ECUfromtheCommunityforafoui–yearperiodbeginningon
1June1980,
-38000ECy^.fromSwitzerlandfortheperiodreferredtointhefirst
paragraphofArticle1. '
TheECUisdefinedintheFinancialRegulationapplicabletothegeneral
budgetofttfeEuropeanCommunities andinthefinancialprovisionsadopted
pursuanttothatRegulation.
TherulesgoverningthefinancingoftheAgreementaresetoutinAnnexC.
'Article5
InaccordancewiththeprocedurelaiddownbytheCommissionafterconsult­
ingtheCommittee,theStatesshallexchangeregularlyallrelevant
information concerningtheexecutionoftheresearchcoveredbythecon­
certedactionprojectandshallforwardtotheCommissionallinformation
whichwillassistco-ordination .Theyshallalsoendeavourtoprovidethe
Commissionwithinformation onresearchinthefieldinquestionplanned
orcarriedoutbybodiesnotsubjecttotheirauthority.Anyinformation
shallbetreatedasconfidential iftheStatewhichprovidesitsorequests.
TheCommissionshallprepareyearlyprogressreportsonthebasisofthe
information suppliedandshallforwardthemtotheStates.
Attheendoftheperiodoftheconcertedactionproject,theCommission,
afterconsulting theCommittee,shallforwardtotheStatesageneral ,
reportonitsexecutionandontheresultsobtained,inparticular sothat
theseresultsaremadeaccessibleasquicklyandasfullyaspossibleto

undertakings,institutions andotherpartiesconcerned,inparticularin***-
thesocialfield.ThisreportshallbepublishedbytheCommissionsix
monthsafterit,is'forwardedtotheStates,unlessaStateobjects.Inth»
lattercase,thereportshallbeforwarded,onrequest,solelytothe-
institutions andundertakings theresearchorproductionactivitiesof
whichjustifyaccesstotheresultsoftheresearchcoveredbythecon­
certedactionproject.-
Article6 '*
1.AssoonaspossibleaftersigningthisAgreement,eachofthecontract­
ingpartiesshallnotifytheSecretary-General oftheCouncilofthe
EuropeanCommunities ofthecompletionoftheproceduresnecessaryunder
itsinternalprovisionsfortheimplementation ofthisAgreement.
2.ThisAgreementshallenterintoforceonthedayonwhichthesecond
ofthecontractingpartiesforwardsthisnotification .~
PriortoentryintoforceofthisAgreementandforamaximumperiodof
ninemonthsafteritis.signed,.Switzerland maytakepartwithoutvoting
rightsinth.eWorkoftheCommittee.
•r , ,
*" /. % -
3.Foraperiodofsix.monthsfollowingitsentryintoforce,thisAgree­
mentshallbeopenforaccessionbyotherEuropeanStateswhichtookpart
intheMinisterial Conference heldinBrusselson22and23November1971.>
Theinstruments ofaccessionshallbedepositedwiththeGeneral
Secretariat ofthe'CounciloftheEuropeanCommunities .,
AStatewhichaccedestothisAgreementshallbecomeacontracting party
withinthemeaningofArticle1onthedateonwhichtheinstrumentof
accessionisdeposited.Itshallcontributetotheco-ordination costs
undertheconditionslaiddowninArticle4concerningSwitzerland .

4.TheSecretary-General oftheCounciloftheEuropeanCommunities shall
notifyeachofthecontracting partiesofthelodgingofthenotifications
referredtoinparagraph 1,ofthedateofentryintoforceofthisAgree­
mentandofthedeposition oftheinstruments ofaccessionreferredtoin
paragraph 3. .
Article7 ^
ThisAgreement,drawnupinasingleoriginalintheDanish,German,Greeks.
English,French,-ItalianandDutchlanguages,eachtextbeing
equallyauthentic,.shalIbedepositedinthearchivesoftheGeneral
Secretariat oftheCounciloftheEuropeanCommunities,whichshalltrans­
mitacertifiedcopytoeachofthecontracting parties.

0
ANNEXA
PROGRAMMES COVERED BYTHEAGREEMENT
/ ..
Implementation andco-ordination ofthenationalcontributions tothe
project
Thefollowingauthorities carryingoutmedicalresearchintheStates
willensuretheimplementation ofthenationalcontributions to~the
projectandtheirco-ordination atnationallevel:-
Belgium: FRSM,Fondsdelarecherchescientifique médicale/
Bruxelles/FondsvoorGeneeskundig Wetenschappelijk
Onderzoek,Brussel
Denmark: Statenslaegevidenskabeli geForskningsråd Kobenhavn
Germany:-ZentrumfürInnereMedizinderUniversität Giessen
-DepartmentfürInnereMedizinderUniversität Ulm.
Greece:-IpiresiaEpistimonikisErevniskeTechnologhias ,
Athens
-SimvoulionIatrikonErevnon,Athens
v .
France: INSERM,Institutnationaldelasantéetdelâ
i recherche médicale,Paris ■-•.-..
Ireland:
Italy:
Netherlands :Gezondheidsorganisatie TNOandStichtingMedisch
Wetenschappelijk Onderzoek FUNGO,DenHaag
UnitedKingdom:MCR,MedicalResearchCouncil,London
Switzerland :TheodorKocherInstitut,Universität,BernMedicalResearchCouncilofIreland,Dublin
4k
CNR,Consiglionazionaledellaricerca,Roma,and
Istitutosuperioredisanità,Roma

«
Projectrelatingtothedetectionofthetendencytothrombosis
Theresearchwillbecarriedoutwiththepurposeofacquiring
scientific andtechnicalknowledgeinthisfield,selectedforits
importanceatCommunitylevel.
Theresearchisexpectedtocoverthefollowingtopics;
!••Detectionofactivatedclottingfactorsandtheirreaction
products ■
2.Quantitative analysisoftheinhibitorsoftheclottingsystem
3.Studiesoftheactiveandinhibitorycomponentsofthe
fibrinolytic system.
4.Studiesofbloodplatelets
5.:Pilotstudiesinwell-defined populations followingstandard­
izationofmaterialsandmethodology
Belgium,Denmark,Germany,Greece,France,Ireland,Italy,the
Netherlands,theUnitedKingdomandSwitzerland willcontribute
researchunderthetopicsmentionedabove.

ANNEXB
TERMSOFREFERENCE ANDCOMPOSITION OFTHECOMMITTEE
TheCommittee shall:*
1.1contributetotheoptimumexecutionoftheprojectbygivingits
opiniononallofitsaspects;
1.2evaluatetheresultsanddrawconclusions asregardstheir
application ; -
1.3beresponsible fortheexchangeofinformation referredtointhe
firstsub-paragraph ofArticle5; ;
1.4keepabreastofnationalresearchbeingdoneinthefields
coveredbytheprojectandmoreespecially ofscientific and
technicaldevelopments likelytoaffecttheexecutionofthe
project;
1.5suggestguidelinestotheprojectleader.
/
TheCommittee'sreportsandopinionsshallbeforwardedtothe
Commission andtotheStates.TheCommission shallforwardthese,
opinionstoCREST.
I
TheCommitteeshallbecomposedof(personsresponsible forco-ordfnat-
>' - ~
ingthenationalcontributions totheprojectandtheprojectleader.
Eachmembermaybeaccompanied byexperts.

i ANNEXC
FINANCING RUUIS
Article 1 -
Theseprovisions LaydownthefinancingrulesreferredtoinArticle4of
theAgreement onaconcertedactionprojectinthefieldofthedetection
ofthe'tendencytothrombosis .
'V-.ï'V
Atthebeginningofeachfinancialyear,theCommissionshallsend,to
Switzerland acallforfundscorresponding toitsshareoftheannual
co-ordination costsundertheAgreement,calculatedinproportiontothe
maximumamounts ^.aiddowninArticle4oftheAgreement.
Thiscontribution shallbeexpressedbothinECUandinthecurrencyof
theStateconcerned,thevalueoftheECUbeingdefinedjntheFinancial
RegulationapplicabletothegeneralbudgetoftheEuropeanCommunities
anddeterminedonthedateofthecallforfunds.j
Thetotalcontributions shallcoverthetravelandsubsistence costsofthe
delegatestotheCommittee,inadditiontotheco-ordination costsproper.
Switzerland shallpayitsannualcontribution totheco-ordination costs
undertheAgreementatthebeginningofeachyearandby31Marchatthe
latest.Anydelayinthepaymentoftheannualcontribution shallgive,
risetothepaymentofinterestbySwitzerland atarateequaltothe
highestdiscountraterulingintheStatesontheduedate.Therate
.shallbeincreasing by0.25ofapercentage pointforeachmonthofdelay.
Thisincreasedrateshallbeappliedtotheentireperiodofdelay.
However,thisinterestshallberecoverable onlyifpaymentismademore
thanthreemonthsaftertheCommission hassentacallforfunds.

ANNEXC
Article 3
*
ThefundspaidbySwitzerland shallbecreditedtotheconcertedaction
projectasbudgetreceiptsallocatedtoaheadinginthestatementof
revenueoftHebudgetoftheCommission . .
Article4
Theprovisional timetablefortheco-ordination costsreferredtoin
Article4oftheAgreementisannexedhereto.
Article 5
TheFinancialRegulationinforceapplicabletothegeneralbudgetofthe
EuropeanCommunities shallapplytothemanagement oftheappropriations .
Article6
Attheendofeachfinancialyear,astatementofappropriations forthe
concertedactionprojectshallbepreparedandtransmitted toSwitzerland
forinformation .

PROVISIONAL TDtETABLES FORTHECONCERTED AnTTONPRO.TOCP:TiWEYTITrsw rrc>top"pmmmrnvnnmmr,imr\rfri
198O 1981 19Í32 1983 l<?8á
,Initialestimateofoverallrequirements
figuresonthecoramitmentsandpayments
scheduleandinthetableofequivalence -
■nAnnexIItothebudgetofthe
Commission)AC AP ACAP AC AP AC ■AP AC AP AC AP
j·77.000\
'77.000"
<1154.000ji54.00047.5OO
3I.5OO
75.00047.5OO
31.500
75.000iI54.OOOI54.OOO
Àj77.000«
j77.000J616.009V
j-Staff
-Administrative operatingexpenditure
-Contractsr616.000
jTOTAL . 77.00077.000154.000154.000 I54.OOO I54.OOO I54.OOO I54.OOO 77.00077.000 616.000 616.000
Revisedestimateofexpendituretaking-into
iaccountadditionalrequirementsarisingfrom
''theaccessionofSwitzerland
– –47.500
34.500
81.50047.500
34.500
81.500,I63.5OOj163.500I63.5OO I63.5OO186.500■86.5001654.00e,
•
.Í
Í-Staff
J
S-Administrative operatingexpenditure
!
j-Contracts ' ^654.000
jjNEWTOTAL(77.000)(77.000)163.500163.500163.500I63.500 I63.5OO 163.500 86.50086.500 654.003654.000
J.Differencebetween1end2tobecoveredby
thecontribution fromSwitzerland– –9.5009.5009.500 9.500 9.5OO 9.5OO 9.5009.500 38.00038.000
AC«Accountcredited
AP■Accountpaid