ANNEX I

STRATEGIC PLANNING AND PROGRAMME ACTIVITIES

The following shall apply in the implementation of the Programme.

STRATEGIC PLANNING

As laid down in Article 4 a, the implementation of the Specific Programme shall be facilitated by a multiannual strategic planning for research and innovation activities . The strategic planning process shall ▌focus in particular on the Global Challenges and European Industrial Competitiveness pillar, including relevant activities in other pillars and the Widening Participation and Strengthening the European Research Area part, also in close coordination and synergy with the planning of the KICs of the EIT established by Regulation 294/2008/EC .

The result of the Strategic Planning Process shall be set out in a Strategic Plan for realising content in the work programme.

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The Strategic Planning process aims to:

— implement Horizon Europe's programme-level objectives in an integrated manner and provide focus on impact for the Programme overall and coherence between its different pillars.

— ▌promote synergies between Horizon Europe and other Union Programmes, including the [cohesion funds] and the Euratom programme, thus becoming a point of reference for research and innovation in all related programmes across the EU budget and non-funding instruments. ▌

— help to develop and realise EU policy for the relevant areas covered, and complement policy development and implementation in the Member States.

— reduce fragmentation of efforts and avoid duplication and overlaps between funding possibilities.

— provide the frame for linking the direct research actions of the Joint Research Centre and other actions supported under the Programme, including the use of results and data for support to policy.

— ensure a balanced and broad approach to research and innovation, at all stages of development, which is not only limited to fostering frontier research, the development of new products processes and services on the basis of scientific and technological knowledge and breakthroughs, but also incorporates the use of existing technologies in novel applications and continuous improvement and non-technological and social innovation.

— ensure a systemic, cross-disciplinary, cross-sectoral and cross-policy approach to research and innovation in order to tackle challenges while also giving rise to new competitive businesses and industries, fostering competition, stimulating private investments and preserving the level playing field in the internal market.

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OTHER PROGRAMME ACTIVITIES

In the ‘Global Challenges and European Industrial Competitiveness’ and the ‘ Innovative Europe ’ Pillars, research and innovation shall be complemented with activities which operate close to the end-users and the market, such as demonstration, piloting or proof-of-concept, excluding however commercialisation activities going beyond the research and innovation phase. This shall also include support to demand-side activities that help accelerate the deployment and diffusion of a broad range of innovations. Emphasis shall be put on non-prescriptive calls for proposals.

Under the ‘Global Challenges and European Industrial Competitiveness’ pillar, building on experience in Horizon 2020, the social sciences and the humanities shall be fully integrated across all clusters, including specific and dedicated activities. Likewise, activities involving marine and maritime research and innovation shall be implemented in a strategic and integrated manner in line with the EU Integrated Maritime Policy, the Common Fisheries Policy ▌and international commitments.

Activities carried out within the ▌FET Flagships▌ on Graphene, the Human Brain Project and Quantum Technology, which are supported under Horizon 2020, will continue being supported under Horizon Europe through calls for proposals included in the work programme ▌. Preparatory actions supported under the FET Flagships part of Horizon 2020 will feed the Strategic Planning process under Horizon Europe and inform the work on missions, co-funded/co-programmed partnerships and regular calls for proposals.

Science and Technology Cooperation dialogues with the EU's international partners and policy dialogues with the main world regions shall make important contributions to the systematic identification of opportunities for cooperation which, when combined with differentiation by country/region, shall support priority setting. Early advice from the ERA-related advisory structure will continue to be sought.

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DISSEMINATION AND COMMUNICATION

Horizon Europe will provide dedicated support for open access to scientific publications, to knowledge repositories and other data sources. Dissemination and knowledge diffusion actions will be supported, also from cooperation with other EU programmes, including clustering and packaging results and data in languages and formats for target audiences and networks for citizens, industry, public administrations, academia, civil society organisations, and policy makers. For this purpose, Horizon Europe may make use of advanced technologies and intelligence tools.

There will be appropriate support for mechanisms to communicate the programme to potential applicants (e.g. National Contact Points).

The Commission will also implement information and communication activities relating to Horizon Europe, to promote the fact that results were obtained with the support of EU funding. They will also seek to raise public awareness on the importance of research and innovation and the broader impact and relevance of EU funded research and innovation, by means of e.g. publications, media relations, events, knowledge repositories, databases, multi-channel platforms, websites or a targeted use of social media. Horizon Europe will also provide support to the beneficiaries to communicate their work and its impact to society at large.

EXPLOITATION AND MARKET UPTAKE

The Commission will establish comprehensive measures for exploitation of Horizon Europe results and the knowledge produced. This will accelerate exploitation towards wide market uptake and boost the impact of the Programme.

The Commission will systematically identify and record the results of the research and innovation activities under the Programme and transfer or disseminate these results and knowledge produced in a non-discriminatory fashion to industry and enterprises of all sizes, public administrations, academia, civil society organisations and policy-makers, in order to maximise the European added value of the Programme.

INTERNATIONAL COOPERATION

Greater impact will be obtained through aligning actions with other countries and regions of the world within strengthened international cooperation efforts ▌. Based on mutual benefit, partners from across the world will be invited to join EU efforts as an integral part of initiatives in support of EU action for sustainability, reinforced research and innovation excellence, and competitiveness.

International joint action will ensure effective tackling of global societal challenges and Sustainable Development Goals, access to the world's best talents, expertise and resources, and enhanced supply and demand of innovative solutions.

WORKING METHODOLOGIES FOR EVALUATION

The use of high quality independent expertise in the evaluation process underpins the engagement of the programme across all stakeholders, communities and interests, and is a prerequisite for maintaining the excellence and relevance of the funded activities.

The Commission or funding body will ensure the impartiality of the process, and avoid conflicts of interest in line with Article 61 of the Financial Regulation. It shall also seek geographical diversity in the composition of evaluation committees, expert and advisory groups.

Exceptionally, when justified by the requirement to appoint the best available experts and/or by the limited size of the pool of qualified experts, independent experts assisting or being members of the evaluation committee may evaluate specific proposals for which they declare a potential interest. In this case, the Commission or funding body shall take all necessary remedial measures to ensure the integrity of the evaluation process. The evaluation process will be managed accordingly, including a stage involving an interaction between diverse experts. The evaluation committee will take into account the particular circumstances when identifying proposals for funding.

PILLAR I

EXCELLENT SCIENCE

The scientific, economic, social and cultural progress in all its forms depends on an adequate supply of excellent researchers; the search for breakthroughs in understanding and the acquisition of knowledge at all levels ; the world class facilities needed to achieve this including physical and knowledge infrastructures for research and innovation as well as the means to openly disseminate and share knowledge (open science) methodologies and skills ▌

The achievement of world leading innovation is linked to the advancements of open and excellent science ▌. Scientific and technological paradigm shifts , can be key drivers for productivity growth, competitiveness, wealth, sustainable development and social progress. Such paradigm shifts have historically tended to originate from the public-sector science base before going on to lay the foundations for whole new industries and sectors and for comprehensive societal progress .

Public investment in research, especially through universities and public research institutions (PRIs) and research facilities, often undertakes the longer-term, higher-risk research and complements the activities of the private sector. Besides this, it creates highly skilled human resources , knowhow and experience, new scientific instruments and methodologies, as well creating the networks which transmit the latest knowledge.

European science and European-based researchers have been and continue to be at the forefront in many areas. But this is not a position we can take for granted. ▌ The traditional challenge from countries such as the United States is now being joined by economic giants such as China and India, from the newly industrialising parts of the world in particular, and from all countries where governments recognise the manifold and abundant returns which derive from investing in research.

1. EUROPEAN RESEARCH COUNCIL (ERC)

1.1. Rationale

Although the EU remains the largest producer of scientific publications in the world, it has ▌, relative to its size, comparatively few centres of excellence that standout at the world level and with large areas of average and poor performance. Compared with the US and now China to some degree, the EU follows a ‘distributed excellence model’ in which resources are spread across a larger number of researchers and research institutions. Creating attractive conditions for the best researchers ▌ will help Europe to raise its attractiveness in the global competition for scientific talent.

The global research landscape is evolving dramatically and becoming increasingly multipolar as a result of a growing number of emerging countries, in particular China, expanding their scientific production. So whereas the EU and the United States accounted for nearly two-thirds of world expenditure on research and development in 2000, this share had fallen to less than half by 2013.

The ERC supports the best researchers , including talented researchers who are at an early stage of their career, with flexible, long-term funding to pursue ground breaking, high-gain/high-risk research primarily in Europe . It operates autonomously led by an independent Scientific Council made up of scientists, engineers and scholars of the highest repute and appropriate expertise and diversity. The ERC is able to draw on a wider pool of talents and ideas than would be possible for any national scheme, reinforcing excellence through the way in which the best researchers and the best ideas compete against each other.

Frontier research funded by the ERC has a proven substantial direct impact in the form of advances at the frontiers of knowledge, opening the way to new and often unexpected scientific and technological results and new areas for research. In turn, this generates radically new ideas which drive innovation and business inventiveness and tackle societal challenges. The ERC also has a significant structural impact, driving up the quality of the European research system over and above the researchers and actions it funds directly. ERC-funded actions and researchers set an inspirational target for frontier research in Europe, raising its profile and making it more attractive for the best researchers worldwide as a place to work, and work with. The prestige of hosting ERC grant- holders creates competition between Europe's universities and research organisations to offer the most attractive conditions for top researchers and can indirectly help them to assess their relative strengths and weaknesses and bring about reforms.

▌The ERC funds a relatively small percentage of all European research, but from this achieves a ▌high scientific impact. The average citation impact of the research supported by the ERC is comparable to that of the world’s top elite research universities. The ERC’s research performance is extremely high when compared with the world’s largest research funders. The ERC funds a great deal of frontier research in many of the research areas that have received the highest numbers of citations, including those areas that are rapidly emerging. Although ERC funding is targeted to frontier research it has resulted in a substantial number of patents.

So there is clear evidence that the ERC attracts and funds excellent researchers through its calls and ERC actions are producing a substantial number of the most significant and high impact research findings worldwide in emerging areas leading to breakthroughs and major advances. The work of ERC grantees is also highly interdisciplinary and ERC grantees collaborate internationally and publish their results openly across all fields of research including the social sciences , research on the arts and the humanities.

There is also already evidence of the longer term impacts of ERC grants on careers, on training highly skilled recognised researchers and holders of doctoral degrees ▌, on raising the global visibility and prestige of European research and on national research systems through its strong benchmarking effect. This effect is particularly valuable in the EU's distributed excellence model because ERC funded status can replace and serve as a more accurate indicator of research quality than recognition based on the status of institutions. This allows ambitious individuals, institutions, regions and countries to seize the initiative and scale up the research profiles in which they are particularly strong.

1.2. Areas of intervention

1.2.1. Frontier Science

Research funded by the ERC is expected to lead to advances at the frontier of knowledge, with scientific publications of the highest quality▌ to achieve research results with high societal and economic potential impact and with the ERC setting a clear and inspirational target for frontier research across the EU, Europe and internationally. Aiming to make the EU a more attractive environment for the world's best scientists, the ERC will target a measurable improvement in the EU's share of the world's top 1 % most highly cited publications, and aim to increase in the number of excellent researchers including from outside Europe which it funds.

ERC funding shall be awarded in accordance with the following well-established principles. Scientific excellence shall be the sole criterion on which ERC grants are awarded. The ERC shall operate on a ‘bottom-up’ basis without predetermined priorities.

Broad Lines

— Long-term funding to support excellent ideas of investigators of any age and gender, from any country in the world, and their research teams to pursue ground-breaking, high-gain/high-risk research;

— Enabling starting and early-stage career researchers with excellent ideas to make the transition to being independent research leaders in their own right by providing adequate support at the critical stage when they are setting up or ▌consolidating their own research team or programme;

— New ways of working in the scientific world , including the open science approach, with the potential to create breakthrough results and facilitate commercial and social innovation potential of funded research;

— Sharing experience and best practices with regional and national research funding agencies and building links to other parts of the Framework Programme, in particular the MSCA, to promote the support of excellent researchers;

— Raising the profile of frontier research in Europe and the visibility of ERC programmes to researchers across Europe and internationally .

1.3. Implementation

1.3.1. The Scientific Council

The Scientific Council is the guarantor of the quality of the activity from the scientific perspective and has full authority over decisions on the type of research to be funded.

In the context of the implementation of the framework programme and in order to carry out its tasks, as set out in Article 7, the Scientific Council will:

(1) Scientific strategy: — establish the overall scientific strategy for the ERC, in the light of scientific opportunities and European scientific needs; — establish the work programme and develop the ERC's mix of support measures in line with its scientific strategy; — establish the necessary international cooperation initiatives including outreach activities, to increase the visibility of the ERC for the best researchers from the rest of the world, in line with its scientific strategy.

(2) Scientific management, monitoring and quality control: — ensure a world-class peer review system based on scientific excellence and on fully transparent, fair and impartial treatment of proposals by establishing positions on implementation and management of calls for proposals, evaluation criteria, peer review processes including the selection of experts, the methods for peer review and proposal evaluation and the necessary implementing rules and guidelines, on the basis of which the proposals to be funded will be determined under the supervision of the Scientific Council; — experts shall be appointed on the basis of a proposal from the ERC Scientific Council in the case of ERC frontier research actions; — ensure that ERC grants are implemented according to simple, transparent procedures that maintain the focus on excellence, encourage initiative and combine flexibility with accountability by continuously monitoring the quality of the operations and implementation; — review and assess the ERC's achievements and the quality and impact of the research funded by the ERC and , accordingly, make recommendations and guidelines for corrective or future actions; — establish positions on any other matter affecting the achievements and impact of the ERC's activities and the quality of the research carried out.

(3) Communication and dissemination: — raise the global profile and visibility of the ERC by conducting communication and outreach activities including scientific conferences to promote the ERC's activities and achievements and the results of the projects funded by the ERC with the scientific community, key stakeholders and the general public; — where appropriate, consult with the scientific, engineering and scholarly community, regional and national research funding agencies and other stakeholders; — regularly report to the Commission on its own activities.

The members of the Scientific Council shall be compensated for the tasks they perform by means of an honorarium and, where appropriate, reimbursement of travel and subsistence expenses.

The President of the ERC will reside in Brussels for the duration of the appointment and devote most of his/her working time (1) to ERC business. He/she will be remunerated at a level commensurate with the Commission's top management and will be provided by the Dedicated Implementation Structure with the necessary support to carry out his or her functions.

The Scientific Council shall elect from amongst its members three Vice-Chairs who shall assist the President in its representation and the organisation of its work. They may also hold the title of Vice-President of the ERC.

Support will be provided to the three Vice-Chairs to ensure adequate local administrative assistance at their home institutes.

1.3.2. Dedicated Implementation Structure

The dedicated implementation structure will be responsible for all aspects of administrative implementation and programme execution, as provided for in the ERC work programme. It will, in particular, implement the evaluation procedures, peer review and selection process in accordance with the strategy established by the Scientific Council and will ensure the financial and scientific management of the grants. The dedicated implementation structure will support the Scientific Council in the conduct of all of its tasks as set out above including the development of its scientific strategy, its monitoring of the operations and its review and assessment of the ERC's achievements as well as its outreach and communications activities, provide access to the necessary documents and data in its possession, and keep the Scientific Council informed of its activities.

In order to ensure an effective liaison with the dedicated implementation structure on strategy and operational matters, the leadership of the Scientific Council and the Director of the dedicated implementation structure will hold regular coordination meetings.

The management of the ERC will be carried out by staff recruited for that purpose, including, where necessary, officials from the EU institutions, and will cover only the real administrative needs in order to assure the stability and continuity necessary for an effective administration.

1.3.3. Role of the Commission

In order to fulfil its responsibilities as set out in Articles 6, 7 and 8 and in the context of its own responsibilities for budget execution, the Commission will:

— ensure the continuity and renewal of the Scientific Council and provide support for a standing Identification Committee for the identification of future Scientific Council members;

— ensure the continuity of the dedicated implementation structure and the delegation of tasks and responsibilities to it taking into account the views of the Scientific Council;

— ensure that the dedicated implementation structure carries out the full range of its tasks and responsibilities;

— appoint the Director and the members of the management of the dedicated implementation structure taking into account the views of the Scientific Council;

— ensure the timely adoption of the work programme, the positions regarding implementing methodology and the necessary implementing rules including the ERC Rules of Submission and the ERC Model Grant Agreement, taking into account the positions of the Scientific Council;

— regularly and in a timely manner inform and consult the Programme Committee on the implementation of the ERC activities;

— as responsible for the overall implementation of the Research Framework Programme, monitor the dedicated implementation structure and evaluate its performance .

2. MARIE SKŁODOWSKA-CURIE ACTIONS (MSCA)

2.1. Rationale

Europe needs a highly-skilled and resilient human capital base in research and innovation that can easily adapt to and find sustainable solutions for current and future challenges, such as major demographic changes in Europe. To ensure excellence, researchers need to be mobile, collaborate and diffuse knowledge across countries, sectors and disciplines, with the right combination of knowledge and skills to tackle societal challenges and support innovation.

Europe is a scientific powerhouse with around 1,8 million researchers working in thousands of universities, research centres and ▌companies. However, it is estimated that the EU will need to train and employ at least one million new researchers by 2027 in order to achieve the targets beings set for increased investment in research and innovation. This need is particularly acute beyond the ▌academic sector (such as in industry and business, including SMEs, government, civil society organisations, cultural institutions, hospitals etc.) and requires collaboration between the different sectors to provide adequately trained new researchers. The EU must reinforce its efforts to entice more young women and men to a career in research, be more inclusive and promote better work/family life balance, attract researchers from third countries, retain its own researchers and reintegrate European researchers working elsewhere back to Europe. In addition, in order to more widely spread excellence, the conditions under which researchers perform must be further improved throughout the European Research Area (ERA). In this respect, stronger links are needed notably with the European Education Area (EEdA), the European Regional Development Fund (ERDF), and European Social Fund (ESF+).

These challenges can best be addressed at EU level due to their systemic nature and to the cross-country effort needed to solve them.

The Marie Skłodowska-Curie Actions (MSCA) focus on excellent research that is fully bottom-up, open to any field of research and innovation from basic research up to market take-up and innovation services. This includes research fields covered under the Treaty on the Functioning of the European Union and the Treaty establishing the European Atomic Energy Community (Euratom). If specific needs arise and additional funding sources become available, the MSCA may seek links to certain activities in specific challenges (incl. identified missions), types of research and innovation institutions, or geographical locations in order to respond to the evolution of Europe's requirements in terms of skills, research training, career development and knowledge sharing.

The MSCA are the main instrument at EU-level for attracting researchers from third countries to Europe, thus making a major contribution to global cooperation in research and innovation. Evidence shows that the MSCA not only have a positive impact on individuals, organisations, and at system level, but also yield high-impact and breakthrough research results while at the same time contributing significantly to societal as well as strategic challenges. Long-term investment in people pays off, as indicated by the number of Nobel Prize winners who have been either former MSCA fellows or supervisors.

Through global research competition between scientists and between host organisations from both the academic and non-academic sector, and through the creation and sharing of high-quality knowledge across countries, sectors and disciplines, the MSCA contribute notably to the goals of the ‘Jobs, growth and investment’ agenda, the EU Global Strategy and to the United Nations Sustainable Development Goals.

The MSCA contribute to making the ERA more effective, competitive and attractive on a global scale. This is achieved by focusing on a new generation of highly-skilled researchers and providing support for emerging talent from across the EU and beyond including fostering their transition to other components of the programme, such as ERC and EIT ; by fostering the diffusion and application of new knowledge and ideas to European policies, the economy and society, inter alia through improved science communication and public outreach measures; by facilitating cooperation between research-performing organisations and by publishing following the principles of open science and FAIR data ; and by having a pronounced structuring impact on the ERA, advocating an open labour market and setting standards for quality training, attractive employment conditions and open , transparent and merit-based recruitment for all researchers in line with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers .

2.2. Areas of Intervention

2.2.1. Nurturing Excellence through Mobility of Researchers across Borders, Sectors and Disciplines

The EU must remain a reference point for excellent research and thus attractive for the most promising researchers, European and non-European alike, at all stages of their careers. This can be achieved by enabling researchers and research-related staff to move and collaborate between countries, sectors and disciplines and thus benefit from high-quality training and career opportunities. This will facilitate career moves between academia and other sectors as well as stimulate entrepreneurial activity.

Broad Lines

— Mobility experiences within or outside Europe for the best or most promising researchers regardless of nationality to undertake excellent research and develop their skills as well as career and broaden their network in academia and other sectors (including research infrastructures) .

2.2.2. Fostering new Skills through Excellent Training of Researchers

The EU needs a strong, resilient and creative human resource base, with the right combination of skills to match the future needs of the labour market, to innovate and to convert knowledge and ideas into products and services for economic and social benefit. This can be achieved through training researchers to further develop their core research competences as well as enhance their transferable skills such as a creative, responsible, open-to-society and entrepreneurial mindset and awareness of sustainable development . This will allow them to face current and future global challenges, and improve their career prospects and innovation potential.

Broad Lines

— Training programmes to equip researchers with a diversity of skills relevant to current and future global challenges.

2.2.3. Strengthening Human Resources and Skills Development across the European Research Area

In order to foster excellence, promote cooperation between research-performing organisations and create a positive structuring effect, high-quality training and mentoring standards, good working conditions and effective career development of researchers need to be introduced across the ERA. If appropriate and justified by a study, support for researchers to return to their country of origin within and to the Union shall be provided within the context of the existing broad lines. This will help modernise or enhance research training programmes and systems as well as increasing institutions' ▌attractiveness worldwide .

Broad Lines

— Training programmes to foster excellence and spread best practices across institutions , research infrastructures and research and innovation systems;

— Inter- and transdisciplinary cooperation , production and diffusion of knowledge within the EU and with third countries.

2.2.4. Improving and Facilitating Synergies

Synergies between research and innovation systems and programmes at EU, regional and national level need to be further developed . This can be achieved in particular through synergies ▌, complementarities with other parts of Horizon Europe such as the European Institute of Innovation and Technology (EIT) and other EU programmes, notably Erasmus and the ESF+, including via a Seal of Excellence.

Broad Lines

— Training programmes and similar research career development initiatives supported through complementary public or private funding sources at regional, national or EU level.

2.2.5. Promoting Public Outreach

The awareness of the programme’s activities and the public recognition of researchers need to be enhanced across the EU and beyond, to raise the global profile of the MSCA and to develop a better understanding of the impact of researchers’ work on citizens’ daily lives, and to encourage young people to embark on research careers. This can be achieved by working according to the open science principle which leads to better dissemination, exploitation and diffusion of knowledge and practices. Citizen science could play a valuable role as well.

Broad Lines

— Public outreach initiatives to stimulate interest in research careers, especially amongst young people of all backgrounds ;

— Promotion activities to raise the global profile, visibility and awareness of the MSCA;

— Diffusion and clustering of knowledge through cross-project collaboration , national contact points (NCP) projects and other networking activities such as an alumni service.

3. RESEARCH INFRASTRUCTURES

3.1. Rationale

State of the art research infrastructures provide key services to research and innovation communities, playing an essential role in extending the frontiers of knowledge and laying the basis for research and innovation contributions to tackle the global challenges and industrial competitiveness . Supporting research infrastructures at the EU level helps to mitigate what in many cases is the reality of scattered national and regional research infrastructures and pockets of scientific excellence, and so strengthening the ERA as well as increasing the ▌circulation of knowledge across silos. Scientific progress is increasingly dependent on the collaborations of research infrastructures and industry that develop the necessary instruments based on new key enabling technologies and other new technologies.

The overall aim is to endow Europe with world-class sustainable research infrastructures open and accessible to all researchers in Europe and beyond, which fully exploit their potential for scientific advance and innovation. Key objectives are to reduce the fragmentation of the research and innovation ecosystem, avoiding duplication of effort, and better coordinate the design, development , accessibility and use of research infrastructures , including those financed from ERDF . It is crucial to support open access to research infrastructures for all European researchers as well as, inter alia through the European Open Science Cloud (hereafter ‘EOSC’), increased access to digital research resources, specifically stimulating the up-take of open science and open data practises.

It is also important to improve the long-term sustainability of research infrastructures as they are typically operational for several decades and therefore should produce plans to secure continuous and stable support.

Equally, the EU needs to tackle the rapid increase of global competition for talent by attracting third country researchers to work with European world-class research infrastructures. Increasing the competitiveness and innovation capabilities of European industry is also a major objective, supporting key technologies and services relevant for research infrastructures and their users, thus improving the conditions for supply of innovative solutions.

Past framework programmes have made a significant contribution towards the more efficient and effective use of national research infrastructures as well as developed with the European Strategy Forum on Research Infrastructures (ESFRI) a coherent and strategy-led approach to policy making on pan-European research infrastructures. This strategic approach has generated clear advantages, including reducing duplication of effort with more efficient overall use of resources, as well as standardising processes and procedures. Research mobility plays an important role in facilitating the use of research infrastructures, therefore synergies with national and European mobility schemes have to be considered.

EU supported activity will provide added value through: consolidating and optimising the existing research infrastructure landscape in Europe alongside efforts to develop new research infrastructures of pan-European importance and impact; ensuring similar sets of research infrastructures work together to address strategic issues affecting user communities ; establishing the European Open Science Cloud (EOSC) as an effective scalable and sustainable environment for data-driven research; the interconnection of national and regional research and education networks, enhancing and securing high-capacity network infrastructure for massive amounts of data and access to digital resources across borders and domain boundaries; promoting the pan-European coverage of distributed research infrastructures, also to enable cross-country comparison of research data, e.g. in the SSH and environmental fields; fostering the interoperability of research infrastructures; enhancing and reinforcing knowledge transfer and training of high-skilled human resources; fostering the use and where relevant upgrading of existing world-class pan-European research infrastructures across Horizon Europe; overcoming barriers preventing the best research teams from accessing the best research infrastructures services in Europe ; fostering the innovation potential of research infrastructures, focused on technology development and co-innovation as well as increased use of research infrastructures by industry.

And the international dimension of EU research infrastructures must be reinforced, fostering stronger cooperation with international counterparts and international participation in European research infrastructures for mutual benefit.

Activities will contribute to different Sustainable Development Goals (SDGs) such as: SDG 3 — Good Health and Well-Being for People; SDG 7 — Affordable and Clean Energy; SDG 9 — Industry Innovation and Infrastructure; SDG 13 — Climate Action.

3.2. Areas of intervention

3.2.1. Consolidating and Developing the Landscape of European Research Infrastructures

The establishment, operation and long-term sustainability of research infrastructures identified by ESFRI and other world-class research infrastructures of pan-European relevance is essential for the EU to ensure a leading position in frontier research, training and upskilling of researchers, the creation and use of knowledge and the competitiveness of its industries.

The European Open Science Cloud (EOSC) should become an effective and comprehensive delivery channel for research infrastructures services and should provide Europe's research communities with the next generation of data services for harvesting, storing, processing (e.g. analytics, simulation, visualisation services) and sharing big science data according to the FAIR principles . The EOSC should also provide researchers in Europe with access to the majority of data generated and collected by research infrastructures as well as to HPC and exascale resources , including those deployed under the European Data Infrastructure (EDI) (2).

The pan-European research and education network will link together and enable remote access to research infrastructures and research resources, by providing interconnectivity between universities, research institutes and research and innovation communities at EU level as well as international connections to other partner networks worldwide.

Broad Lines

— The life-cycle of pan European research infrastructures through the design of new research infrastructures; their preparatory and implementation phase, their early-phase operation in complementarity with other funding sources, in case of the research infrastructures supported by structural funds, as well as the consolidation and optimisation of the research infrastructure ecosystem by streamlining the monitoring practice for ESFRI landmarks and other pan-European research infrastructures and facilitating service agreements, evolutions, mergers , pan-European coverage or decommissioning of pan-European research infrastructures;

— The European Open Science Cloud, including: scalability and sustainability of the access channel; in cooperation with the Member States and the associated countries effective federation of European, national, regional and institutional resources; its technical and policy evolution to cope with new research needs and requirements (e.g. usage of sensitive data sets, privacy by design); data inter-operability and compliance with the FAIR principles; and a wide user base;

— The pan-European research and education network underpinning the EOSC and EDI as well as enabling the delivery of HPC/data services in a cloud based environment capable of coping with extreme large data sets and computational processes.

3.2.2. Opening, Integrating and Interconnecting Research Infrastructures

The research landscape will be improved through ensuring openness of key international, national and regional research infrastructures for all European researchers and integrating their services when necessary so as to harmonise access conditions, improve and enlarge service provision and encourage common development strategy of high tech components and advanced services through innovation actions.

Broad Lines

— Networks that bring together national and regional funders of research infrastructures for the co-funding of trans-national access of researchers;

— Networks of pan -European , national and regional research infrastructures addressing global challenges for the provision of access to researchers as well as for the harmonisation and improvement of the research infrastructures' services.

3.2.2a The innovation potential of European Research Infrastructures and activities for Innovation and Training

To stimulate innovation both in the ▌research infrastructures themselves and in industries, R&D cooperation with industry will be fostered to develop Union capacities and demand for industrial supply in high-tech ▌areas such as scientific instrumentation ▌. In addition, the use of research infrastructures by industry, e.g. as experimental test facilities or knowledge-based centres, will be encouraged. The development and exploitation of research infrastructures will require appropriate skills for their managers, researchers, engineers and technicians, as well as users. For this purpose, Union funding will support the training of staff managing and operating research infrastructures of pan-European interest, the exchange of staff and best practices between facilities, and the adequate supply of human resources in key disciplines, including the emergence of specific education curricula. Synergies with the Marie Skłodowska-Curie actions will be encouraged .

Broad lines

— Integrated networks of research infrastructures for the preparation and implementation of a common strategy/roadmap for technological development and instrumentation;

— training of staff managing and operating research infrastructures of pan-European interest.

3.2.2b Reinforcing European Research Infrastructure policy and International Cooperation

Support is needed so that policy makers, funding bodies or advisory groups such as ESFRI are well-aligned towards developing and implementing a coherent and sustainable long-term European strategy on research infrastructures.

Similarly, enabling strategic international cooperation will strengthen of the position of European research infrastructures at international level, ensuring their global networking ▌, interoperability and reach.

Broad Lines

— Survey, monitoring and assessment of research infrastructures at EU level, as well as policy studies, communication and training actions, strategic international cooperation actions for research infrastructures, and specific activities of relevant policy and advisory bodies.

PILLAR II

GLOBAL CHALLENGES AND EUROPEAN INDUSTRIAL COMPETITIVENESS

▌ The EU is confronted by many challenges , some of which ▌are also global challenges. The scale and complexity of the problems are vast, ▌ need to be tackled jointly and matched by adequate, properly trained and skilled human resources, by the appropriate amount of financial resources and a proportionate effort in order to find solutions. These are precisely the areas where the EU must work together; smart, flexible and joined-up for the benefit and well-being of all our citizens.

Greater impact can be obtained through aligning actions with other nations and regions of the world within ▌international cooperation along the lines indicated by the United Nations 2030 Agenda for Sustainable Development and the Sustainable Development Goals and the Paris climate agreement. Based on mutual benefit, partners from across the world will be invited to join EU efforts as an integral part of research and innovation for sustainable development .

Research and innovation are key drivers of sustainable and inclusive growth and technological and industrial competitiveness ▌. They will contribute to finding solutions to today’s problems, and the problems of tomorrow, in order to reverse as quickly as possible, the negative and dangerous trend that currently links economic development▌with the growing use of natural resources and growing social challenges. This will turn the challenges into new business opportunities and into rapid benefits for society .

The EU will benefit as user and producer of knowledge, technologies and industries showcasing how modern industrialised, sustainable, inclusive, creative, resilient, open and democratic society and economy can function and develop. The growing economic-environmental-social examples of the sustainable ▌economy of the future will be fostered and boosted, be they for: health and well-being for all; or resilient , creative and inclusive ▌societies; or societies strengthened by civil security; or available clean energy and mobility; or a digitised economy and society; or a transdisciplinary and creative industry; or space related, marine or land-based solutions; or a well-functioning bioeconomy, including food and nutrition solutions; sustainable use of natural resources▌, protection of the environment, climate change mitigation and adaptation, all generating wealth in Europe and offering higher quality jobs. Industrial transformation will be crucial , as well as developing EU innovative industrial value chains .

New technologies affect virtually all policy areas. For each separate technology there is often a combination of social and economic opportunities, opportunities for efficiency and quality and improvement of the government, consequences for employment and education, but also possible risks for safety, privacy and ethics.Technology policy therefore necessarily requires an integral weighing of interests, and cross-sectoral cooperation and strategy formulation.

Research and innovation under this pillar of Horizon Europe is grouped into integrated , non-siloed broad clusters of activities. Rather than addressing sectors, the investments aim at systemic changes for our society and economy along a sustainability vector. These will only be achieved if all actors, both private and public, engage in co-designing and co-creating research and innovation; bringing together end-users, scientists, technologists, producers, innovators, businesses, educators, policy-makers, citizens and civil society organisations. Therefore, none of the ▌clusters is intended for only one set of actors and all activities will be implemented primarily by collaborative research and innovation projects selected on the basis of competitive calls for proposals .

In addition to addressing global challenges, activities in the clusters will also develop and apply ▌key enabling and emerging technologies (either or not digital-based) as part of a common strategy to promote the EU's industrial and social leadership. Where appropriate this will use EU space-enabled data and services. All TRL levels up to 8 will be covered in this pillar of Horizon Europe without prejudice to Union competition law.

Actions will generate new knowledge and develop technological and non-technological solutions, bring technology from lab to market and to develop applications including pilot lines and demonstrators, and include measures to stimulate market uptake and to boost private sector commitment and incentives to standardisation activities within the Union. Technologies require critical mass of European researchers and industry to establish world leading eco-systems, that include state of the art technology infrastructures e.g. for testing . Synergies with other parts of Horizon Europe and the EIT, as well as other programmes will be maximised.

The clusters will boost the quick introduction of first-of-its-kind innovation in the EU through a broad range of embedded activities, including communication, dissemination and exploitation, standardisation as well as support to non-technological innovation and innovative delivery mechanisms, helping create innovation friendly societal, regulatory and market conditions such as the innovation deals. Pipelines of innovative solutions originating from research and innovation actions will be established and targeted to public and private investors as well as other relevant EU and national or regional programmes. Synergies will be developed with the third pillar of Horizon Europe in that perspective.

Gender equality is a crucial factor in order to obtain sustainable economic growth. It is therefore important to integrate a gender perspective in all global challenges.

1. CLUSTER ‘HEALTH’

1.1. Rationale

The EU Pillar of Social Rights asserts that everyone has the right to timely access to affordable, preventive and curative health care that is safe and of good quality. This underlines the EU’s commitment to the UN’s Sustainable Development Goals calling for universal health coverage for all and at all ages by 2030, leaving no one behind, and ending preventable deaths.

A healthy population is vital for a stable, sustainable and inclusive society, and improvements in health are crucial in reducing poverty, in dealing with an ageing European society, in fostering social progress and prosperity, and in increasing economic growth. According to the OECD a 10 % improvement in life expectancy is▌associated with a rise in economic growth of 0,3-0,4 % a year. Life expectancy in the EU increased by 12 years since its establishment as a result of tremendous improvements achieved in the quality of life, environment, education, health and care of its people. In 2015, overall life expectancy at birth was 80,6 years in the EU compared to 71,4 years globally. In the past years, it increased in the EU on average by 3 months annually. Besides these improvements social and gender-specific differences in life expectancy can be observed between specific groups and across European countries.

Health ▌research and innovation have played a significant part in this achievement but also in improving productivity and quality in the health and care industry. However, the EU continues to face novel, newly emerging or persisting challenges that are threatening its citizens and public health, the sustainability of its health care and social protection systems, as well as the competitiveness of its health and care industry. Major health challenges in the EU include: accessibility and affordability of health and care; the lack of effective health promotion and disease prevention; the rise of non-communicable diseases; the increased cases of cancer; the increase of mental illness; the spread of antimicrobial drug resistance and the emergence of infectious epidemics; increased environmental pollution; the persistence of health inequalities among and within countries ▌disproportionally affecting people that are disadvantaged or in vulnerable stages of life; the detection, understanding, control, prevention and mitigation of health risks , including poverty-related aspects, in a rapidly changing social, urban , rural and natural environment; demographic change, including ageing-related issues, and the increasing costs for European health care systems▌ and the increasing pressure on the European health and care industry to remain competitive in and by developing health innovation vis-a-vis ▌emerging global players. In addition, vaccine hesitancy may decrease immunisation coverage among certain population groups.

These health challenges are complex, interlinked and global in nature and require multidisciplinary, technical and non-technical, cross-sectorial and transnational collaborations. Research and innovation activities will build close linkages between discovery, clinical, translational epidemiological, ethical, environmental and socio-economic research as well as with regulatory sciences. They will address areas of unmet clinical needs such as for example rare or hard to treat diseases (cancers, such as paediatric and lung cancer). They will harness the combined skills of academia, practitioners, regulatory bodies and industry and foster their collaboration with health services, social services, patients, policy-makers and citizens in order to leverage on public funding and ensure the uptake of results in clinical practice as well as in health care systems taking into account the competencies of Member States regarding the organisation and financing of their health systems . Full advantage will be taken of genomic and other multiomics frontier research, as well as the progressive introduction of personalised medicine approaches, relevant for addressing a variety of non-communicable diseases and the digitalisation in health and care.

Research and innovation will foster strategic collaboration at EU and international level in order to pool the expertise, capacities and resources needed to create scope, speed and economies of scale, ▌as well as to exploit synergies, avoid duplication of effort and share the expected benefits and financial risks involved. Synergies in health research and innovation in Horizon Europe shall be promoted, in particular with the Health Strand within the European Social Fund Plus.

Digital health solutions have created many opportunities to solve the problems of care services and to address other emerging issues of ageing society. Full advantage should be taken of the opportunities that digitalisation in health and care can provide without jeopardising the right to privacy and data protection. Digital devices and software have been developed to diagnose, treat and facilitate patients’ self-management of illness, including chronic diseases. Digital technologies are also increasingly used in medical training and education and for patients and other healthcare consumers to access, share and create health information.

The research and innovation activities of this global challenge will develop the knowledge base, exploit existing knowledge and technologies, consolidate and create the research and innovation capacity and develop the solutions needed for a more effective promotion of health and the integrated prevention, diagnosis, monitoring, treatment , rehabilitation and cure of diseases and (long-term and palliative) care . Results of research will be translated as recommendations for action and communicated with the relevant stakeholders. Improving health outcomes will in turn result in increased well-being and life expectancy, healthy active lives , improved quality of life and productivity▌, more healthy life years and sustainability of health and care systems. In line with articles 14 and 15 of the Regulation and the Charter for Human Rights and Fundamental Principles, ethics, protection of human dignity, gender and ethnical aspects and the needs of disadvantaged and vulnerable people will receive special attention.

Addressing major health challenges will support the EU’s commitment to the United Nation's 2030 Agenda for Sustainable Development and those in the context of other UN organisations and international initiatives, including the global strategies and plans of action of the World Health Organization (WHO). It will contribute to the EU's policy goals and strategies, notably to the EU Pillar of Social Rights, the EU Digital Single Market, the EU Directive on cross-border healthcare, and the European One Health Action Plan against antimicrobial resistance (AMR), and to the implementation of the relevant EU regulatory frameworks.▌

Activities will contribute directly to the following Sustainable Development Goal (SDGs) in particular: SDG 3 — Good Health and Well-Being for People; SDG13 — Climate Action.

1.2. Areas of Intervention

1.2.1. Health throughout the Life Course

People in vulnerable stages of life ( perinatal, birth, infancy, childhood, adolescence, pregnancy, mature and late adulthood), including people with disabilities or injuries, have specific health needs that require better understanding and tailored solutions , taking gender and ethical aspects into consideration . This will allow reducing related health inequalities and improving health outcomes to the benefit of active and healthy ageing throughout the life course, including through a healthy start of life and diet reducing the risk of mental and physical diseases later in life. Prevention and communication will consider characteristics of specific audiences.

Broad Lines

— Understanding the early development and the aging process throughout the life course;

— pre- and neo-natal, maternal , paternal, infant and child health as well as the role of parents , family and educators ;

— Health needs of adolescents , including factors influencing mental health ;

— Health consequences of disabilities and injuries;

— Research on measures to plan, implement and monitor rehabilitation throughout the life course and especially early individual rehabilitation programme (EIRP) for children affected by disabling pathologies;

— Healthy ageing, independent and active life , including social participation for the elderly and/or disabled people;

— Health education and ▌health literacy , including digital .

1.2.2. Environmental and Social Health Determinants

Improved understanding of health drivers and risk factors determined by the social, cultural, economic and physical environment in people’s everyday life and at the workplace, including the health impact of digitalisation, human mobility (such as migration and travel), pollution, nutrition, climate change and other environmental issues, will contribute to identify , prevent and mitigate health risks and threats; to reducing death and illness from exposure to chemicals and environmental pollution; to supporting safe, environmental-friendly, healthy, resilient and sustainable living and working environments; to promoting healthy lifestyles and consumption behaviour; and to developing an equitable, inclusive and trusted society. This will also be based on population based cohorts, human biomonitoring and epidemiological studies.

Broad Lines

— Technologies and methodologies for assessing hazards, exposures and health impact of chemicals, indoor and outdoor pollutants and other stressors related to climate change, workplace, lifestyle or the environment and combined effects of several stressors;

— Environmental, occupational, socioeconomic, cultural, genetic and behavioural factors impacting physical and mental health and well-being of people and their interaction, with special attention to vulnerable and disadvantaged people , age-specific and gender-specific issues where relevant, and including the impact on health of the design of buildings, products and services ;

— Risk assessment, management and communication, supported by transdisciplinary approaches, where relevant, and improved tools for evidence-based decision-making, including replacement of and alternatives to animal testing;

— Capacity and infrastructures to securely collect, share , use, re-use and combine data on all health determinants, including human exposure and ensure their connection with databases on environmental parameters, lifestyles , health status and diseases, at EU and international level;

— Health promotion and primary prevention interventions , including occupational aspects .

1.2.3. Non-Communicable and Rare Diseases

Non-communicable diseases (NCDs), including cancer, rare diseases, pose a major health and societal challenge and call for improved understanding and taxonomy, as well as more effective approaches ▌, including personalised medicine (also called ‘precision medicine’) approaches, in prevention, diagnosis, monitoring, treatment, rehabilitation and cure as well as understanding of multimorbidities .

Broad Lines

— Understanding the mechanisms underlying the development of non-communicable diseases, including Cardiovascular diseases;

— Longitudinal population studies to support understanding health and disease parameters and help stratifying populations in support of the development of preventive medicine;

— Diagnostic tools and techniques for earlier and more accurate diagnosis and for timely patient-adapted treatment , enabling delay and/or reversal of the progression of disease ;

— Prevention and screening programmes , in line with or going beyond WHO, UN and EU recommendations ;

— Integrated solutions for self-monitoring, health promotion, disease prevention, and management of chronic conditions and multi-morbidities , including neurodegenerative and cardiovascular diseases ;

— Treatments , ▌ cures or other therapeutic interventions , including both pharmacological and nonpharmacological treatments;

— Palliative care;

— Areas of high unmet clinical need, such as rare diseases, including paediatric cancers;

— Assessment of comparative effectiveness of interventions and solutions , including based on Real World Data (RWD) ;

— Implementation research to scale up health interventions and support their uptake in health policies and systems;

— Development of research and improvement of information, care and treatment, including personalised medicine, for rare diseases.

1.2.4. Infectious Diseases , including poverty-related and neglected diseases

Protecting people against cross-border health threats is a major challenge for public and global health, calling for effective international cooperation at EU and global level. This will involve understanding and prevention of , preparedness for , early detection of and research response to outbreaks , treatment and cure of infectious diseases, including poverty-related and neglected diseases, and also tackling antimicrobial resistance (AMR) following a ‘One Health approach’.

Broad Lines

— Understanding infection-related mechanisms;

— Drivers for the emergence or re-emergence of infectious diseases and their spread, including transmission from animals to humans (zoonosis), or from other parts of the environment (water, soil, plants, food) to humans , as well as impact of climate change and ecosystems evolutions on the dynamics of infectious diseases ;

— Prediction, early and rapid detection , control and surveillance of infectious diseases, ▌ healthcare-associated infections and environmental related factors;

— Combatting antimicrobial resistance, including epidemiology, prevention, diagnosis, as well as the development of new antimicrobials and vaccines;

— Vaccines, including vaccine platform technologies, diagnostics, treatments and cures for infectious diseases, including co-morbidities and co-infections;

— Addressing low vaccine uptake, understanding vaccine hesitancy and building vaccine confidence;

— Effective health emergency preparedness, response and recovery measures and strategies, involving communities , and their coordination at regional, national and EU level ;

— Barriers to the implementation and uptake of medical interventions in clinical practice as well as in the healthcare system;

— Trans-border aspects of infectious diseases and specific challenges in low- and middle-income countries (LMICs), such as AIDS, tuberculosis and tropical diseases , including malaria, also in relation to migratory flows and, in general, to increased human mobility .

1.2.5. Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine

Health technologies and tools are vital for public health and contributed to a large extent to the important improvements achieved in the quality of life, health and care of people, in the EU. It is thus a key strategic challenge to design, develop, deliver ▌, implement and evaluate suitable, trustable, safe, user-friendly and cost-effective tools and technologies for health and care, taking due account of the needs of people with disabilities and the aging society. These include key enabling technologies from new biomaterials to biotechnology as well as single cell methods, multiomics and systems medicine approaches, artificial intelligence and other digital technologies, offering significant improvements over existing ones, as well as stimulating a competitive and sustainable health-related industry that creates high-value jobs. The European health-related industry is one of the critical economic sectors in the EU, accounting for 3 % of GDP and 1,5 million employees. Relevant stakeholders need to be involved as early as possible, and the non-technological dimension will be taken into account, in order to ensure acceptability of new technologies, methodologies and tools. This includes citizens, health care providers and professionals.

Broad Lines

— Tools and technologies for applications across the health spectrum and any relevant medical indication, including functional impairment;

— Integrated tools, technologies , medical devices, medical imaging, biotechnology, nanomedicine and advanced therapies (including cellular and gene therapy), and digital solutions for human health and care , including artificial intelligence, mobile solutions and telehealth , while addressing, when relevant, cost-efficiency production aspects at an early stage (in order to optimize the industrialisation stage and the potential of innovation to become an affordable medicinal product) ;

— Piloting, large-scale deployment, optimisation, and innovation procurement of health and care technologies and tools in real-life settings including clinical trials, implementation research including diagnostics based on personalised medicine ;

— Innovative processes and services for the development, manufacturing and rapid delivery of tools and technologies for health and care;

— The safety, efficacy , cost-effectiveness, interoperability and quality of tools and technologies for health and care as well as their ethical, legal and social impact , including social acceptance issues ;

— Regulatory science and standards for health and care technologies and tools;

— Health data management, including data interoperability, integration, analytical and visualisation methods, decision making processes, building on artificial intelligence, data mining, big data technologies, bioinformatics and high performance computing technologies to foster personalised medicine including prevention, and to optimise the health journey.

1.2.6. Health Care Systems

Health systems are a key asset of the EU social systems, accounting for 24 million employees in the health and social work sector in 2017. It is a main priority of Member States to render health systems safe and secure, accessible for all, integrated , cost-effective, resilient, sustainable and trusted with timely and relevant services, as well as to reduce inequalities, including by unleashing the potential of data-driven and digital innovation for better health and person-centred care building on open and safe European data infrastructures. New opportunities such as 5G deployment, the concept of ‘digital twins’ and the Internet of Things will advance the digital transformation of health and care.

Broad Lines

— Supporting the knowledge base for reforms in health systems and policies in Europe and beyond;

— New models and approaches for health and care , including personalised medicine approaches, management and organisational aspects, and their transferability or adaptation from one country/region to another;

— Improving health technology assessment;

— Evolution of health inequality and effective policy response;

— Future health workforce and its needs , including digital skills ;

— Improving timely , reliable, safe and trustworthy health information and use /reuse of health data, including electronic health records, with due attention to data protection, including the misuse of personal life style and health information, security, accessibility , interoperability, standards, comparability and integrity;

— Health systems resilience in absorbing the impact of crises and to accommodate disruptive innovation;

— Solutions for citizen and patient empowerment, self-monitoring, and interaction with health and social care professionals, for more integrated care and a user-centred approach , while considering equal access ;

— Data, information, knowledge and best practice from health systems research at EU-level and globally building on existing knowledge and databases .

2. CLUSTER ‘ CULTURE, CREATIVITY AND ▌INCLUSIVE SOCIETY’

2.1. Rationale

The EU stands for a unique way of combining economic growth with sustainable development goals and social policies, with high levels of social inclusion, shared values embracing democracy, human rights, gender equality and the richness of diversity. This model is constantly evolving and needs to deal with the challenges from amongst other things, globalisation and technological change and rising inequalities . ▌

The EU must promote a model of inclusive and sustainable growth while reaping the benefits of technological advancements, enhancing trust in and promoting innovation of democratic governance, fostering education, combatting inequalities, unemployment, marginalisation, discrimination and radicalisation, guaranteeing human rights, fostering cultural diversity and European cultural heritage and empowering citizens through social innovation. The management of migration and the integration of migrants will also continue to be priority issues. The role of research and innovation in ▌ social sciences , ▌ humanities , and arts, as well as in the cultural and creative sectors, in responding to these challenges and achieving the EU’s goals is fundamental. In particular SSH aspects are included in all intervention areas of this cluster.

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The magnitude, complexity , intergenerational and trans-national character of the challenges call for multi-layered EU action. Addressing such critical social, political, cultural and economic issues ▌ only at national level would carry the danger of inefficient use of resources, fragmented approaches and dissimilar standards of knowledge and capacity.

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Research and Innovation activities in this Global Challenge will be overall aligned with the EU 's priorities on Democratic Change; Jobs, Growth and Investment; Justice and Fundamental Rights; Migration; A Deeper and Fairer European Monetary Union; Digital Single Market. It will respond to the commitment of the Rome Agenda to work towards: ‘a social Europe’ and ‘a Union which preserves our cultural heritage and promotes cultural diversity’. It will also support the European Pillar of Social Rights, and the Global Compact for safe, orderly and regular migration. ▌ Synergies with the Justice Programme and with the Rights and Values Programme, which support activities in the area of access to justice, victims' rights, gender equality, non-discrimination, data protection and promotion of the European citizenship , as well as with the Creative Europe and Digital Europe programme, Erasmus, Erasmus+ and European Social Fund Plus, will be exploited.

Activities will contribute directly to the following Sustainable Development Goals (SDGs) in particular: SDG 1 — No Poverty; SDG 3 — Good Health and Well-Being for People; SDG 4 — Quality Education; SDG 5 — Gender Equality; SDG 8 — Decent Work and Economic Growth; SDG 9 — Industry, Innovation and Infrastructure; SDG 10 — Reducing Inequalities; SDG 11- Sustainable Cities and Communities; SDG 16 — Peace, Justice and Strong Institutions.

2.2. Areas of Intervention

2.2.1. Democracy and Governance

Trust in democracy and established political institutions seems to be receding. Disenchantment with politics is increasingly articulated by anti-establishment and populist parties and a resurgent nativism. This is compounded by socio-economic inequalities, high migration flows and security concerns , among others . Responding to present and future challenges requires new thinking on how democratic institutions at all levels must adapt in a context of greater diversity, global economic competition, rapid technological advancements and digitisation, with citizens' experience of democratic discourses , practices and institutions being crucial.

Broad Lines

— The history, evolution and efficacy of democracies, at different levels and in different forms; ▌ the role of education , cultural and youth policies as cornerstones of democratic citizenship;

— The role of social capital and access to culture in strengthening democratic dialogue and civic participation, open and trusting societies.

— Innovative and responsible approaches to support the transparency, accessibility, responsiveness, accountability , trustworthiness, resilience, effectiveness and legitimacy of democratic governance in full respect of fundamental and human rights and of the rule of law;

— Strategies to address populism, racism, polarisation, corruption, extremism, radicalisation, terrorism and to include , empower and engage ▌ citizens;

— Analysis and development of social, economic and political inclusion and inter-cultural dynamics in Europe and beyond;

— Better understand the role of journalistic standards and user-generated content in a hyper-connected society and develop tools to combat disinformation;

— The role of multi-cultural including spiritual identities in relation to democracy, citizenship and political engagement , as well as EU founding values such as respect, tolerance, gender equality, cooperation and dialogue ;

— Support research to understand identity and belonging across communities, regions and nations;

— The impact of technological and scientific advancements, including big data, online social networks and artificial intelligence on democracy , privacy and the freedom of speech ;

— Deliberative , ▌ participatory and direct democracy and governance and active and inclusive citizenship, including the digital dimension;

— The impact of economic and social inequalities on political participation and democratic governance, and research on to what extent it can contribute to reversing inequalities and combatting all forms of discrimination including gender, to a more resilient democracy;

— Human, social and political dimensions of criminality, dogmatism and radicalisation, in relation to those engaged or potentially engaged in such behaviour as well as to those affected or potentially affected;

— Combatting disinformation, fake news and hate speech, and their impact in shaping the public sphere;

— The EU as an international and regional actor in multilateral governance, including new approaches to science diplomacy.

— Efficiency of justice systems and improved access to justice based on judiciary independence and principles and human rights, with fair, efficient and transparent procedural methods both in civil and criminal matters.

2.2.2. Cultural Heritage

The European cultural and creative sectors build bridges between arts, culture, spiritual beliefs and experiences and cultural heritage, business and technology. Furthermore, Cultural and Creative Industries (CCIs) play a key role in reindustrialising Europe, are a driver for growth and are in a strategic position to trigger innovative spill-overs in other industrial sectors, such as tourism, retail, media and digital technologies and engineering. Cultural heritage forms an integral part of the cultural and creative sectors and is the fabric of our lives, meaningful to communities, groups and societies, giving a sense of belonging. It is the bridge between the past and the future of our societies. A better understanding of our cultural heritage and how it is perceived and interpreted are vital to creating an inclusive society in Europe and worldwide. It is also a driving force of European, national, regional and local economies and a powerful source of inspiration for creative and cultural industries. Accessing, conserving, safeguarding and restoring, interpreting and harnessing the full potential of our cultural heritage are crucial challenges now and for future generations. Cultural heritage , tangible and intangible, is the major input and inspiration for the arts, traditional craftsmanship, the cultural, creative and entrepreneurial ▌ sectors that are drivers of sustainable economic growth, new job creation and external trade. In this sense, both innovation and resilience of cultural heritage need to be considered in collaboration with local communities and relevant stakeholders. It also may serve as an agent of cultural diplomacy and as a factor of identity building and cultural and social cohesion.

Broad Lines

— Heritage studies and sciences, with cutting edge technologies and innovative methodologies, including digital ones;

— Access to and sharing of cultural heritage, with innovative patterns and uses and participatory management models;

— Research for the accessibility of cultural heritage through new technologies, such as cloud services, including but not limited to a European cultural heritage collaborative space, as well as encouraging and facilitating transmission of know-how and skills. This will be preceded by an impact assessment;

— Sustainable business models to strengthen the financial foundation of the heritage sector;

— Connect cultural heritage with emerging creative sectors , including interactive media, and social innovation ;

— The contribution of cultural heritage to sustainable development through conservation, safeguarding , developing and regeneration of cultural landscapes, with the EU as a laboratory for heritage-based innovation and sustainable cultural tourism;

— Conservation, safeguarding, enhancement , ▌ restoration and sustainable management of cultural heritage and languages including the use of traditional skills and crafts or cutting edge technologies including digital;

— Influence of cultural memories, traditions, behavioural patterns, perceptions, beliefs, values, sense of belonging and identities. The role of culture and cultural heritage in multi-cultural societies and patterns of cultural inclusion and exclusion .

2.2.3. Social and Economic Transformations

European societies are undergoing profound socio-economic and cultural transformations, especially as a result of globalisation and technological innovations. At the same time there has been an increase in income inequality in most European countries (3). Forward-looking policies are needed, with a view to promoting sustainable and inclusive growth , gender equality, well-being and reversing inequalities, boosting productivity (including advancements in its measurement), socio-spatial inequalities and human capital, understanding and responding to migration and integration challenges and supporting intergenerational solidarity , intercultural dialogue and social mobility. Accessible, inclusive and high quality education and training systems are needed for a more equitable and prosperous future.

Broad Lines

— Knowledge base for advice on investments and policies especially education and training, for high value added skills, productivity, social mobility, growth, social innovation and job creation. The role of education and training to tackle inequalities and underpin inclusion, including school-failure prevention ;

— Social sustainability beyond GDP only indicators especially new economic and business models and new financial technologies;

— Statistical and other economic tools for a better understanding of growth and innovation in a context of sluggish productivity gains and/or structural economic changes ;

— New governance models in emerging economic areas and market institutions;

— New types of work, the role of work, upskilling, trends and changes in labour markets and income in contemporary societies, and their impacts on income distribution, work-life balance, working environments, non-discrimination including gender equality and social inclusion;

— Greater understanding of the societal changes in Europe and their impact;

— The effects of social, technological and economic transformations on access to safe, healthy, affordable and sustainable housing;

— Tax and benefits systems together with social security and social investment policies with a view to reversing inequalities in a fair and sustainable way and addressing the ▌ impacts of technology, demographics and diversity;

— Inclusive and sustainable development and growth models for urban, semi-urban and rural environments;

— Understanding human mobility and its impacts in the context of social and economic transformations, considered in the global and local scales for better migration governance, respect of differences, long-term integration of migrants including refugees and impact of related policy interventions ; respect of international commitments and human rights and issues of development aid and cooperation ; greater, improved access to quality education, training, l abour market, culture, support services, active and inclusive citizenship especially for the vulnerable , including migrants ;

— Tackling of major challenges concerning European models for social cohesion, immigration, integration, demographic change, ageing, disability, education, poverty and social exclusion;

— Advanced strategies and innovative methods for gender equality in all social, economic and cultural domains, and to deal with gender biases and gender-based violence.

— Education and training systems to foster and make the best use of the EU's digital transformation, also to manage the risks from global interconnectedness and technological innovations, especially emerging online risks, ethical concerns, socio-economic inequalities and radical changes in markets;

— Modernisation of public authorities governance and management systems to engage citizens and meet their expectation regarding service provision, transparency, accessibility, openness, accountability and user centricity.

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3. CLUSTER ‘CIVIL SECURITY FOR SOCIETY’

3.1. Rationale

European cooperation has contributed to an era of unprecedented peace, stability and prosperity on the European continent. However, Europe has to respond to the challenges arising from persistent threats to the security of our increasingly complex and digitalised society. Terrorist attacks and radicalisation, as well as cyber-attacks and hybrid threats, raise major security concerns and put particular strain on societies. New, emerging security threats caused by new technologies in the near future, also require attention. Future security and prosperity depend on improving the abilities to protect Europe against such threats. These cannot be dealt with purely by technological means but require knowledge about people, their history, culture and behaviour, and include ethical considerations regarding the balance between security and freedom. Moreover, Europe has to ensure its non-dependence on security-critical technologies and support the development of breakthrough security technologies.

European citizens, state institutions, EU bodies and the economy need to be protected from the continued threats of terrorism and organised crime, including firearms trafficking, drug trafficking and trafficking in human beings and trafficking of cultural goods. Human and social dimensions of criminality and violent radicalisation require better understanding so as to improve public policies in terms of security. Strengthening protection and security through better border management, including maritime and land borders, is also key. Cybercrime is on the increase and related risks are diversifying as the economy and society digitalise. Europe needs to continue its efforts to improve cybersecurity, digital privacy, personal data protection and combat the spread of false and harmful information in order to safeguard democratic, social and economic stability. Further efforts are required to limit the effects on lives and livelihoods of extreme weather events which are intensifying due to climate change, such as floods, storms, heat waves or droughts leading to forest fires, land degradation and other natural disasters, e.g. earthquakes. Disasters, whether natural or human-made, can put at risk important societal functions and critical infrastructures, such as communication, health, food, drinking water, energy supply, transport, security and government.

This requires both technical research and research into the human factors involved to improve disaster resilience, including, where appropriate, testing applications, training and cyber hygiene and education. More efforts are needed to evaluate the results of security research and promote their uptake.

This cluster will seek synergies, in particular with the following Programmes: Internal Security Fund, Integrated Border Management Fund and Digital Europe as well as improved research and innovation cooperation between intergovernmental agencies and organisations including through exchange and consultation mechanisms for example in the intervention area ‘Protection and Security’.

Security research is part of the wider comprehensive EU response to security threats. It contributes to the capability development process by enabling the future availability of technologies, techniques and applications to fill capability gaps identified by policy-makers and practitioners and civil society organisations. Already, funding to research through the EU's framework programme has represented around 50 % of total public funding for security research in the EU. Full use will be made of available instruments, including the European space programme (Galileo and EGNOS, Copernicus, Space Situational Awareness and Governmental Satellite Communications). Whereas research and innovation activities under this Programme will have an exclusive focus on civil applications, coordination with EU-funded defence research will be sought in order to strengthen synergies, recognizing that there are areas of dual-use technology. Duplication of funding is avoided. Cross-border collaboration contributes to developing a European single security market and improving industrial performance, underpinning the EU's autonomy. Due attention will be given to the human understanding and perception of security.

Security research responds to the commitment of the Rome Agenda to work towards ‘a safe and secure Europe’, contributing to a genuine and effective Security Union

Activities will contribute directly to the following Sustainable Development Goals (SDGs) in particular: SDG 16 — Peace, Justice and Strong Institutions.

3.1.1. Disaster-Resilient Societies

Disasters may arise from multiple sources, whether natural or human -made, including those from terrorist attacks, climate-related and other extreme events (including from sea level rises), from forest fires, heat waves, floods, droughts, desertification, earthquakes, tsunamis and volcanic events, from water crises, from space weather events, from industrial and transport disasters, from CBRN events, as well as those from resulting cascading risks. The aim is to prevent and reduce the loss of life, harm to health and the environment, trauma as well as economic and material damage from disasters, ensure food, medicine supply and services and water security as well as to improve the understanding and reduction of disaster risks and enhance post-disaster recovery . This implies covering the full spectrum of crisis management: from prevention and training, to crisis management and post-crisis management and resilience.

Broad Lines

— Technologies, capabilities and governance for first responders for emergency operations in crisis , disaster and post- disaster situations and the initial phase of recovery ;

— The capacities of society to better prevent, manage and reduce disaster risk, including through nature-based solutions, by enhancing forecasting capabilities, prevention, preparedness and response to existing and new risks and domino effects, impact assessment and a better understanding of the human factor in risk management and risk communication strategies ;

— More effectively support the build-back-better philosophy of the Sendai Framework through better understanding of post-disaster recovery and research into more effective post-disaster risk assessment.

— Interoperability of equipment and procedures to facilitate cross-border operational cooperation and an integrated EU market.

3.1.2. Protection and Security

There is a need to protect citizens from and to respond to security threats from criminal including terrorist activities and hybrid threats; to protect people, public spaces and critical infrastructure, from both physical (including CBRN-E) attacks and cyber-attacks; to fight terrorism and violent radicalisation, including understanding and tackling terrorist ideas and beliefs; to prevent and fight serious crime, including cybercrime, and organised crime (such as piracy and counterfeiting of products); to support victims; to trace criminal financial flows ; to develop new forensic capabilities ; to support the use of data for law enforcement and to ensure the protection of personal data in law enforcement activities; to strengthen border protection capabilities, to support air, land and sea EU border management, for flows of people and goods and to understand the human factor in all these security threats and in their prevention and mitigation . It is essential to maintain flexibility to rapidly address new and unforeseen security challenges that may arise.

Broad Lines

— Innovative approaches and technologies for security practitioners (such as police forces, fire brigades, medical services, border and coast guards, customs offices), in particular in the context of digital transformation and interoperability of security forces, operators of infrastructure, civil society organisations, and those managing open spaces;

— Analysis of cross-border crime phenomena, advanced methods of fast, reliable, standardised and privacy enhanced data sharing and collection as well as best practices;

— Human and socio-economic dimensions of criminality and violent radicalisation, in relation to those engaged or potentially engaged in such behaviour as well as to those affected or potentially affected , including understanding and tackling terrorist ideas and beliefs and crimes based on gender, sexual orientation or racial discrimination ;

— Analysis of security aspects of new technologies such as DNA-sequencing, genome editing, nanomaterials and functional materials, Artificial Intelligence, autonomous systems, drones, robotics, quantum computing, cryptocurrencies, 3D printing and wearables, blockchain, as well as improving awareness of citizens, public authorities and industry to prevent the creation of new security risks and to reduce existing risks, including from those new technologies ▌ ;

— Improved foresight and analysis capabilities for policy making and at strategic level on security threats;

— Protection of critical infrastructures as well as open and public spaces from physical, digital and hybrid threats, including the effects of climate change;

— Monitoring and combatting disinformation and fake news with implications for security , including developing capabilities to detect the sources of manipulation ;

— Technological development for civil applications with the scope to enhance, where appropriate, interoperability between civil protection and military forces;

— Interoperability of equipment and procedures to facilitate cross-border , intergovernmental and inter-agency operational cooperation, and develop an integrated EU market;

— Developing tools and methods for an effective and efficient Integrated Border Management, in particular to increase reaction capability and improved capacity to monitor movements across external borders to enhance risk detection, incident responding and crime prevention;

— Detection of fraudulent activities at border crossing points and throughout the supply chain, including identifying forged or otherwise manipulated documents and detecting trafficking in human beings and illicit goods;

— Ensuring the protection of personal data in law enforcement activities, in particular in view of rapid technological developments , including confidentiality and integrity of information and traceability and processing of all transactions;

— Developing techniques for identifying counterfeit products, for enhancing protection of original parts and goods and for controlling transported products.

3.1.3. Cybersecurity

Malicious cyber activities not only threaten our economies but also the very functioning of our democracies, our freedoms and our values. Cyber threats are often criminal, motivated by profit, but they can also be political and strategic. Our future security , freedom, democracy and prosperity depend on improving our ability to protect the EU against cyber threats. The digital transformation requires improving cybersecurity substantially, to ensure the protection of the huge number of IoT devices expected to be connected to the internet, and the safe operation of network and information systems, including for power grids, drinking water supply and distribution, vehicles and transport systems , hospitals, finances, public institutions, factories, homes. Europe must build resilience to cyber-attacks and create effective cyber deterrence , while making sure that data protection and the freedom of citizens are strengthened . It is in the Union's interest to ensure that it develops and retains essential cybersecurity strategic capacities in order to secure the Digital Single Market, and, in particular, to ensure the protection of critical networks and of information systems and to provide key cybersecurity services. The Union must be in a position to autonomously secure its digital assets and to compete on the global cybersecurity market.

Broad Lines

— Technologies across the digital value chain (from secure components and quantum-resistant cryptography to self-healing software and networks);

— Technologies , methods, standards and best practices to address ▌ cybersecurity threats, anticipating future needs, and sustaining a competitive European industry , including tools for electronic identification, threat detection, cyber hygiene, as well as training and education resources ;

— An open collaboration for European cybersecurity competence network and competence centre.

4. CLUSTER ‘DIGITAL, INDUSTRY AND SPACE’

4.1. Rationale

To ensure industrial competitiveness and the capacity to address the global challenges ahead, the EU must increase its technological sovereignty and its scientific, technological and industrial capacities in the key areas that underpin the transformation of our economy , the work place and society.

EU industry provides one out of five jobs and two thirds of private sector R&D investments and generates 80 % of EU exports. A new wave of innovation, involving a merging of physical and digital technologies, will trigger huge opportunities for EU industry and improve the quality of life for EU citizens.

Digitisation is a major driver. As it continues at a rapid pace across all sectors, investment in priority areas ranging from trustworthy artificial intelligence to next generation internet, high performance computing, photonics , quantum technologies, robotics and micro-/ nano-electronics, becomes essential for the strength of our economy and the sustainability of our society. Investing, producing and using digital technologies provides a major boost to EU economic growth, amounting to an increase of 30 % between 2001 and 2011 alone. In this context, the role of SMEs remains fundamental in the EU, both in terms of growth and jobs. Digital uptake among SMEs promotes competitiveness and sustainability.

Key enabling technologies (4) underpin the blending of the digital and the physical worlds, central to this new global wave of innovation. Investing in research, development, demonstration and deployment of key enabling technologies, and ensuring a secure, sustainable and affordable supply of raw and advanced materials, will secure EU strategic autonomy and help EU industry to significantly reduce its carbon and environmental footprints.

Specific future and emerging technologies will also be pursued as appropriate.

Space is of strategic importance; around 10 % of the EU's GDP depends on the use of space services. The EU has a world-class space sector, with a strong satellite manufacturing industry and a dynamic downstream services sector. Space provides important tools for monitoring, communication, navigation, and surveillance and opens up many business opportunities especially in combination with digital technologies and other sources of data. The EU must make the most of these opportunities by fully exploiting the potential of its space programmes Copernicus, EGNOS and Galileo, and by protecting space and ground infrastructures against threats from space.

The EU has the unique chance of being a global leader and increase its share of world markets, by showcasing how digital transformation, leadership in key enabling and space technologies, the transition to a low-carbon, circular economy and competitiveness can reinforce each other through scientific and technological excellence.

To make the digitised, circular, low-carbon and low-emission economy a reality, action is needed at EU level because of the complexity of value chains, the systemic and multi-disciplinary nature of the technologies and their high development costs, and the cross-sectoral nature of the problems to be addressed. The EU must ensure that all industrial players, and society at large, can benefit from advanced and clean technologies and digitalisation . Developing technologies alone will not suffice. A societal understanding of these technologies and evolutions is crucial for engaging end users and behavioural change .

Industrially-oriented infrastructures, including pilot lines, will help EU businesses, and in particular SMEs, deploy these technologies and improve their innovation performance and may be facilitated also by other EU programmes.

A strong engagement of industry and civil society is essential for setting priorities and developing research and innovation agendas, increasing the leverage of public funding through private and public investments , and ensuring the better uptake of results. Societal understanding and acceptance , including consideration of the design of products, goods and services, are key ingredients for success, as well as a new agenda for industry-relevant skills and standardisation.

Bringing together activities on digital, key enabling and space technologies, as well as a sustainable supply of raw materials, will allow for a more systemic approach, and a faster and more profound digital and industrial transformation. It will ensure that research and innovation in these areas feed into, and contribute to the implementation of, the EU’s policies for industry, digitisation, environment, energy and climate, circular economy, raw and advanced materials and space.

Complementarity will be ensured with activities in particular unde