Her research focuses on asthma and chronic rhinosinusitis. She is a Principal Investigator of multiple clinical trials evaluating the efficacy & safety of traditional and experimental drugs in asthma. Dr. Hudes collaborates with Department of Otorhinolaryngology on the research project evaluating nasal dust mite specific immunoglobulins in patients with allergic and non-allergic chronic rhinosinusitis. Her past research focused on immune changes in patients with bronchial asthma during speleotherapy in karst caves. She has published journal articles, abstracts, review articles and book chapters. She mentored numerous fellows, residents and medical students, rotating through Allergy Division.