The overarching goal of his research program is to elucidate how environmental hazards that damage the DNA lead to deleterious human health outcomes. He utilizes a reductionist approach consisting of structural biology, biophysical, kinetic, and molecular biology assays to investigate complex biological questions related to DNA damage and repair. By combining this multi-disciplinary approach with both clinical and cellular collaborations he ultimately hopes to beneficially impact the treatment and prevention of DNA damage associated human diseases.