He is also a licensed marriage and family therapist, who originally trained in the UK as a systemic psychotherapist, and he is Editor-in-Chief for the International Journal of Sexual and Relationship Therapy. His therapeutic work is currently focused on transgender and gender non-conforming youth, and their families; sexuality, and relationships. Iantaffi has conducted research, and published on gender, disability, sexuality, deafness, education, sexual health, HIV prevention, and transgender issues. His scholarly work has been increasingly focused on issues of intersectionality and sexual health disparities. He is currently principal investigator for a study, funded by the National Institutes of Health (NIH), on deaf men who have sex with men (MSM), HIV testing and prevention, and technology.