She started her film career in Lebanon in 2000 and made several short documentary and fiction films. From 2005 to 2010, she worked as a Programme Producer at Al Jazeera in Doha. In 2010, after completing an MFA in Screenwriting, Itani decided to pursue an independent filmmaking career. ‘Twice Upon a Time’ is her debut feature-length film. Her short film ‘Super.Full.’ (2011), played and won awards at international film festivals including the Venice Film Festival. 'Twice Upon a Time' won critical acclaim on its premiere at the Edinburgh International Film Festival.