Her main research interests are environmental, molecular epidemiological, and global health. Her research includes study of how environmental factors link to health risks, including how chemical exposures may influence maternal health and alter epigenetic mechanisms in utero that could contribute to chronic diseases later in life. She is the director of the community engagement core of OSU's Superfund Research Center. In this role, she works with Native American Tribes in the Pacific Northwest to investigate their concerns about environmental pollution. Kile received her doctorate from Harvard School of Public Health in Environmental Health and continued postdoctoral training at Harvard in molecular epidemiology.