His areas of expertise are general neurosurgery and surgery for epilepsy, trigeminal neuralgia, and movement disorders including Parkinson’s disease. The primary focus of Dr. Papanastassiou’s clinical work is surgery for medically intractable epilepsy, movement disorders, and trigeminal neuralgia. He has expertise in resective surgery, radiosurgery, and neuromodulation, including deep brain stimulation and microvascular decompression. A multi-disciplinary approach is used, benefitting from advanced techniques in microneurosurgery, brain mapping, image-guided neurosurgery, and minimally invasive neurosurgery. Dr. Papanastassiou is also active in developing novel applicationas for neuromodulation.