He is the theme leader on Sepsis, Infection and Inflammation for the Paediatric Critical Care Research Group (PCCRG), Mater Research Institute. His research is focusing on severe infections in critically ill patients, including epidemiology, genomics and interventional research, and Luregn has been leading several studies of the ANZPIC registry. He is involved in several national and international trials, and has received funding from NHMRC, SNF, and H2020 for studies on severe respiratory and invasive infections in children.