Her interest in film began while studying graphic design in college, where she made her first short film after learning of a classmate's battle with AIDS. After the film’s great reception she decided to pursue an MFA at NYU's Tisch School of the Arts where she has made numerous shorts films including A Sweet Song. Prempeh's work has been a winner of the Insitut du Français sponsored Accra Francophone Film Festival, winner of the Wasserman award for best editing, a Wasserman Finalist and official selection for the BFI London Film Festival. Prempeh hopes the emotive and observational style of her films will encourage positive action in others. She is currently developing her first feature film Mortar in Ghana.