Her research at WVU aims to understand how sex differences modify brain responses to acute and chronic systemic inflammation. She combines in vivo mouse models of experimental sepsis, cerebral ischemia, and Alzheimer’s disease with in vitro brain microvascular endothelial cell (BMEC) models to conduct this research. She currently studies how tissue nonspecific alkaline phosphatase (TNAP) maintains cerebral microvascular homeostasis during acute systemic inflammation. Her hopes are that this research will identify both the short-term and long-term repercussions of acute systemic inflammatory conditions like sepsis and stroke on brain function, as well as uncover some of the sex-specific factors that contribute to neurological dysfunction and disease.