His clinical practice is associated with the University of Virginia’s Center of Clinical Toxicology. He has published extensively in the medical literature with over 100 publications in medical journals, periodicals, and books. Dr. Holstege speaks extensively on various topics in the field of medical toxicology, with a focus on areas such as criminal poisoners and chemical weapons of mass destruction. He has been integrally involved in the diagnosis and management of a number of high profile criminal poisonings, including the dioxin poisoning of the Ukrainian President Viktor Yushchenko.