He has worked in the area of sexual and reproductive health, including HIV/AIDS, for 15 years and published extensively on the topic. He has also served as an External Examiner in Population Studies/Demography at Makerere University in Uganda, North West University in South Africa and National University of Lesotho in Lesotho. In addition to working in academia, Professor Letamo has worked with United Nations Population Fund as an Assistant Representative in the Botswana country office where his responsibilities included programme monitoring and implementation for 2 years. Prof. Letamo has also served in various national committees and written peer-reviewed articles submitted for publication in journals of international reputation dealing with issues of HIV and AIDS.