Since the start of her career in 2000, she has worked extensively in the Middle East, South and Central Asia and Africa, covering topics such as droughts, refugees emergencies, illegal mining, mass migrations, large scale land grabbing and climate change for more than one hundred newspapers and magazines worldwide. In 2014, Matilde founded the agency Tandem Reportages along with journalist Matteo Fagotto. She has received numerous awards, including the IPA, Px3, Lens Culture Award, the Invisible Photographer of Asia, the International Color Award and the San Francisco International Award.