His clinical interests include acute respiratory distress syndrome, nosocomial infections, sepsis and quality improvement in critical care. He is a co-investigator on both the NIH/NHLBI EPVent multicenter trial of esophageal pressure-guided ventilation for ARDS and a new initiative focused on optimizing ICU safety through patient engagement, system science and information technology sponsored by the Gordon and Betty Moore Foundation. He has received numerous awards for his ongoing commitment to teaching students and trainees, including the Robert Moellering, Herrman Blumgart, and S. Robert Stone teaching awards, and the Katherine Swan Ginsburg Faculty Award for Medical Humanism.