A native Minnesotan, Grande enjoys caring for Minnesotans and feels a great sense of community and affinity to the University of Minnesota. His clinical interests are in the treatment of cerebral vascular diseases using either open vascular or endovascular techniques. He has specific interests in the treatment of complex aneurysms, arteriovenous malformations (AVMs) and Moya Moya disease. Grande also treats trigeminal neuralgia and regularly collaborates with other departments to determine the best treatment options for his patients. Grande also co-directs the Earl Grande Stroke and Stem Cell Laboratory at the University of Minnesota.