His laboratory develops novel methods for processing neuroimaging data, and uses the methods to clarify the biological course of late-life cognitive decline. Currently, his efforts are focused on developing techniques for delineating and quantifying regions of interest on brain MRI, and using the methods to assess the effects of white matter disease and Alzheimer’s disease in large elderly MRI data sets including the Alzheimer’s Disease Neuroimaging Initiative and Cardiovascular Health Study Cognition Study.