She received her MD degree from University of South Florida in 1992 and completed her Internal Medicine Residency at the University of Utah in 1995. In addition, Dr. Wyckoff completed a fellowship in Endocrinology, Metabolism and Diabetes at the Brigham and Women's Hospital, Harvard Medical School, in 1999. Following that, she joined the faculty of the Joslin Diabetes Center. While there, she practiced as part of the multidisciplinary Diabetes and Pregnancy outpatient clinic and inpatient service, a joint venture between the Joslin Diabetes Center and the Beth Israel Deaconess Hospital.