Her current research focuses on biomedical primary prevention interventions, for adolescents and young adults, including PrEP and microbicides, and the development of behavioral interventions to improve uptake and adherence to these new biomedical strategies. In addition to her independent NIH grants, Dr. Hosek has joined the protocol teams of several NIAID-network adolescent/young adult PrEP safety and demonstration studies in sub-Saharan Africa, including HPTN 082, IMPAACT 2009 and MTN 034. Finally Dr. Hosek is currently vice-chair of the IMPAACT Prevention Scientific Committee and co-chair of both the HPTN Adolescents-at-Risk Scientific Committee and the HANC Youth Prevention Research Working Group.