His laboratory performs basic and translational research to identify novel mechanisms that activate the plasma kallikrein system and new actions of plasma kallikrein, which contribute to vasogenic edema and the vascular complications of diabetes. Findings from his laboratory have implicated plasma kallikrein as a VEGF-independent mediator of Diabetic Macular Edema. Additional studies from his laboratory have shown that activated plasma kallikrein can also worsen intracerebral hemorrhage and stroke. These findings have shed new light of the roles of the plasma kallikrein system in vascular disorders and diabetic complications. Ed has over 25 years of research experience in vascular biology and diabetic complications, which includes retinal, cerebrovascular, and cardiovascular studies.