Dr. Bhaskar and his lab studies the relationship between microglia-specific neuroinflammation and tau pathology using various disease models Alzheimer’s disease. His previous studies have shown that interleukin-1 beta (IL-1beta) secreted from reactive microglia induces pathological modifications in tau, which then leads to cognitive impairment and neurodegeneration. Dr. Bhaskar’s lab is currently understanding the mechanisms of inflammasomes activation and IL-1beta maturation in mouse models of tauopathy.