His research interests concentrate on personalized medicine in the critical care including: generation of patient-specific physiological targets; early detection of secondary complications through real-time analysis of patient monitoring data; the use of clinical informatics to support patient management decisions; and identifying modifiable factors that drive health outcomes following critical brain injuries. Michael was the lead author of the 2014 neuromonitoring informatics guidelines for the Neurocritical Care Society and European Society of Intensive Care Medicine. His research has been funded by The Dana Foundation, C.S. Draper Laboratories, IBM, NIH CTSA, and the Department of Defense.