He is a Professor in the McGill University's Departments of Neurology & Neurosurgery and of Physiology as well as Professor of Human Physiology in the Department of Experimental Medicine at the Sapienza University of Rome. Dr. Avoli’s main interests are directed to the fundamental abnormalities that lead to the generation of seizures by employing electrophysiological recording in in vivo and in vitro experimental models of epilepsy. In his current research, Dr. Avoli explores the role played by inhibitory and excitatory mechanisms in the synchronicity of neuronal networks of the limbic system, and thus in seizure initiation. He is also addressing the changes in excitability that contributes to epileptogenesis in temporal lobe epilepsy as well as the mechanisms of action of anti-epileptic drugs.