Prior to joining the University of Minnesota, he was an Associate Consultant in the Department of Health Sciences Research at Mayo Clinic with a focus on clinical data science in the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery. His background is in computer science and statistics and his current research interest primarily focuses on developing novel large-scale data mining approaches towards discovering clinical knowledge from electronic health records, image and genomic data, and integrating this knowledge into clinical decision support for increasingly personalized treatments. Dr. Simon is the principal investigator or co-investigator on several extramural grants from NSF and NIH addressing computational issues in the application of data science to health care.