He studies phosphorylation in tyrosine kinase signaling pathways and the protein-protein interactions that take place when the SH2 domain of one protein binds to a phosphorylated tyrosine residue of the other protein. SH2 domains are often found in adaptor proteins that bind other proteins to trigger the activation or deactivation of downstream proteins in the RTK signaling pathway. Deregulation of RTK signaling pathways lead to a variety of diseases such as cancer and leukemia.