Her research interests are in the toxicology of metals, specifically arsenic and tungsten. Current research on arsenic is focused on investigating its effects on macrophages and how that affects the development of artherosclerosis. She first linked arsenic exposure to inhibition of nuclear receptors, specifically those that heterodimerize with the retinoid X receptor. Dr. Mann is an active member of the Society of Toxicology, and currently serves as the secretary and treasurer of the Metals Specialty Section. She received her PhD in pathology and immunology from Boston University.