Research in the Moses lab is focused on two major areas: regulatory networks & systems and population genomics. Their work on regulatory networks & systems aims to understand two basic questions: 1) how gene regulation is encoded in DNA and protein sequences, and 2) how gene regulation evolves. They quantify changes in the sequences that specify gene regulation and develop mathematical modeling methods to study evolution of regulatory networks. They are also investigating how genetic differences in yeast are distributed in the population, applying mathematical models of molecular evolution to predict how natural selection and genetic drift affect mutations in functional sequences.