Dr. Calakos is interested in understanding the mechanisms of synaptic plasticity and how specific types of synaptic plasticity influence behaviors. Her experiments probe these areas at two levels. One is investigating the “nuts and bolts” of the molecular machinery affecting synaptic plasticity and the changing strength and nature of neurons. Another is examining the behavioral significance of specific plasticity and finding possible therapeutics to help patients. She is particularly drawn to the dysfunction of the basal ganglia circuitry, as seen in the movement disorders dystonia and Tourette’s syndrome as well as neuropsychiatric diseases. Utilizing brain slices from mouse models of these diseases, the lab takes measurements of synaptic strength and integrity using electrophysiological techniques.