He earned his bachelor's degree in molecular biochemistry and biochemistry at Yale University, his medical degree at the Albert Einstein College of Medicine, and completed his pediatric residency and pediatric endocrinology fellowship at the Children's Hospital of Philadelphia (CHOP). He stayed on as a faculty member in the Department of Pediatrics at the University of Pennsylvania, where he initiated the use of continuous glucose sensors in the CHOP Diabetes Center for Children and also helped to develop the Pediatric Type 2 Diabetes Program. Dr. Weinzimer returned to Yale in 2002 to focus his research on the applicability of technology, especially continuous glucose sensors and insulin pumps, to the development of automated insulin delivery (artificial pancreas) for children with type 1 diabetes.