In the seven years since he started his lab, Stuber has become internationally known for his work characterizing neural circuits underlying behaviors associated with addiction, depression, and eating disorders. Stuber has contributed to knowledge of specific circuits and neurotransmitters associated with addictive behaviors and of how drug abuse modulates neural coding dynamics. He pioneered cell-level resolution in vivo calcium imaging, and his addiction research has led to the development and use of optogenetic technologies and provided insight into how synaptic plasticity is involved in drug addiction.