The focus of her research is to understand and overcome mechanisms of chemotherapy resistance and relapse in pediatric acute myeloid leukemia (AML). Research projects in her lab are focused on understanding the patterns of aberrant STAT pathway signaling, the association of specific signaling patterns with clinical outcome, and interactions between leukemia cells and the bone marrow microenvironment. She also is involved in preclinical evaluation of novel therapeutics targeting chemotherapy resistance mechanisms.