After qualifying in Manchester in 1988 his postgraduate training was undertaken in the North West. He worked at many of the major teaching hospitals including The Christie Hospital Cancer Institute, was awarded an MD Thesis in 2000 and after a brief period working in America took up a Consultant post at Manchester Royal Infirmary in 2002. After nearly three years he moved to Poole to build laparoscopic and pelvic floor surgery locally. Andrew Clarke is one of a number of surgeons in the UK to routinely perform the HALO operation for treatment of haemorrhoids.