His laboratory focuses on understanding glial development and dysfunction using a combination of human stem and progenitor cells with animal models of neurological disease. Dr. Sim earned his undergraduate and Ph.D. degrees from the University of Cambridge (UK) in Neuroscience. He received postdoctoral training at the University of Cambridge, Weill Cornell University Medical College, and University of Rochester Medical Center with Drs. Robin Franklin and Steven Goldman. In 2009, he joined the faculty of SUNY University at Buffalo. He has developed novel methods to identify and isolate defined progenitor cells from the human brain. By genomic analysis of these purified cell populations, he has identified novel pharmacological targets for treatment of myelin disease.