Her research program focuses on molecular and cellular aspects of sperm development in fruit flies. Fruit flies are used as model organisms to understand sperm development in mammalian species, including humans. Her research relies upon the use of imaging technology, including confocal laser scanning microscopy and electron microscopy. Prior to arriving at Seton Hall, Klaus worked in industry, non-profit, and governmental sectors as a technologist and biologist, including at the American Museum of Natural History, the National Science Foundation and ExxonMobil. Klaus received her Ph.D. in Cell and Developmental Biology from Rutgers-New Brunswick.