She is an expert in reconstruction and analysis of genome-scale biochemical networks, which can be converted into a mathematical format and enable computation of physiological properties. She has authored many papers on network reconstruction including a widely used standard operating procedure for network reconstruction [4]. Her research focuses on developing computational modeling and metabolomics methods to unravel mechanisms underlying pathophysiological states in various diseases. Dr. Thiele has particular expertise in multi-scale modeling, where processes on different time or spatial scales are integrated into a single model. This research is essential to bridge the gap between molecular level processes, occurring on relatively fast timescales, and clinical level processes, which proceed on slower timescales.