At the Thayer School of Engineering, his research group is seeking to develop and utilize tools for protein design and engineering while placing a priority on therapeutic applications. Karl studied as a DOW Foundation Scholar at Texas State University, receiving a B.S. in chemistry in 1995. After working two years at Thermo Electron Corporation and two years with Huntsman Corporation, he returned to academia receiving a Ph.D. from the University of Texas at Austin in 2005. Following a postdoctoral fellowship with George Georgiou, he joined the Dartmouth Thayer School of Engineering faculty, where he continues to teach and maintain an interdisciplinary research group. In September of 2013, he co-founded the biotechnology startup Stealth Biologics LLC, where he serves as CEO. Working with partners in the biopharmaceutical industry, Stealth Biologics is pursuing development of novel, deimmunized, protein therapeutics.