He oversees a basic research lab focused on the study of musculoskeletal disease, in particular for scoliosis. Gray uses mouse and zebrafish model systems, merging modern molecular genetics with diverse imaging approaches to elucidate the pathogenesis of musculoskeletal disease. Gray is particularly interested in a condition known as adolescent idiopathic scoliosis, which is a complex curvature of the spine that occurs during adolescence in otherwise healthy children. Gray also serves as adjunct faculty in the Department of Nutritional Sciences in the College of Natural Sciences.