He focuses his research on the investigation of the psychosocial and neurobiological mechanisms underlying symptom improvement in psychotherapeutic and pharmacological interventions for depression, with a particular focus on cognitive behavioral approaches. A clearer understanding of the “active ingredients” of treatment and mechanisms of symptom change may ultimately inform the development of more targeted—and ideally more effective and efficient—treatments. In addition, a clearer understanding of factors that cause and maintain depressive symptoms can help inform interventions aimed at treating and preventing depression. Thus, in parallel with his treatment research, Dr. Webb also conducts research focused on clarifying the etiology and underlying pathophysiology of depression.