He received his PhD in Chemistry from California Institute of Technology. He has been applying chemical and biophysical principles to understand the role of protein function in signaling and to elucidate the molecular basis of specific diseases. He is developing computational methods to predict the structure and functional activity of GPCRs, to predict protein-protein interactions, and to rationally design drugs with minimal side-effects. The computational studies are tightly coupled to experiments to generate and test hypotheses about the role of specific proteins and mutations in the normal and disease state of cells.