His research has focused on the neurobiology and pharmacotherapy of cocaine and opioid dependence. Specifically, his studies have evaluated the extent that enhancing GABA neurotransmission may have in modifying cocaine and opiate taking behavior. In addition, his current project is evaluating whether modulation of glutamate neurotransmission by NMDA receptor antagonist during opioid agonist treatment may improve treatment outcomes and reduce early relapse in young adults with opiate dependence.