Dr. Chuang has extensive experience in yeast genetic, biochemistry and molecular biology. He has studied the mechanism of initiation of DNA replication in yeast Schizosaccharomyces pombe and initiation of mRNA translation in yeast Saccharomyces cerevisiae. Dr. Chuang has developed several yeast genetic tools specific for engineering bacterial genome cloned in yeast. He is also a co-investor of a technique, called Tandem Repeat-Endonuclease Cleavage, for seamless modifications of bacterial genomes cloned in yeast.