He is also Co- Director of the Penn Memory Center and Associate Director of Penn’s Alzheimer’s Disease Core Center (Leader of the Clinical Core). His primary clinical interest has been in the diagnosis and care of individuals with a variety of neurodegenerative conditions. Dr. Wolk’s research has focused on the cognitive neurosience of memory decline associated with aging and Mild Cognitive Impairment/Alzheimer’s Disease. A highly related additional line of his work has been the development and examination of biomarkers for detection of early disease changes that differentiate normal aging from evidence of neurodegenerative pathophysiology.