Dr. Domino's research interests include the economics of mental health, agency relationships among physicians, patients and insurers, the diffusion of new technologies, and the public provision of health care and health insurance to low income populations. She has published scholarly work on the impact of managed care on treatment selection for depression in both public and private settings, the impact of managed care on the field of psychiatry, behavioral health carve-outs, and the effect that Medicare Part D has on individuals with severe mental illness.