He owned and operated his public accounting firm, Ruben Escobedo & Company, CPAs, in San Antonio, since its formation in 1977 through 2007. He also serves as a director of Cullen/Frost Bankers Inc. He has served as a director of Valero or its former parent company since 1994. His past directorships include Valero Energy Corporation, Frost Bankers, United Way of San Antonio & Bexar County, Catholic Association of Latino Leaders, and CST Brands Inc.