He is Professor of Health eResearch at the Health eResearch Centre/Farr Institute, University of Manchester. Previously, he was the Scientific Director of the Clinical Practice Research Datalink. One of his current research interests is Efficient Trials, which aims to harness advanced health informatics and electronic health records to improve clinical trials. Another interest is the Learning HealthCare System in which routinely collected data are used to feedback actionable information to clinicians and patients. He has published over 200 peer-reviewed articles and is a well-recognised speaker in the field of pragmatic trials and clinical epidemiology.