He studies how environmental agents can affect genetics — specifically the ways these gene-environment interactions cause mutations and epigenetic changes that may lead to cancer and other diseases. One area of his research focuses on the molecular paths metals and environmental estrogens take to alter the epigenome. Another project explores how space — microgravity and radiation — affects the epigenome. In this work, Singh's lab studies how the space conditions can affect physiology and lead to known changes to the immune system, muscles and bone.