A graduate of Peking University, he received a Ph.D. from Johns Hopkins University, working with Hongjun Song on neuronal DNA methylation in the adult brain. As a Damon Runyon Fellow in David Bartel's laboratory at the Whitehead Institute/MIT, he developed a series of computational and experimental methods to investigate circular RNAs and intracellular RNA folding. Started in 2017, his laboratory at Yale aims to develop new tools to study post-transcriptional regulations of mRNAs and noncoding RNAs in the nervous system, as well as their dysregulation in neurological disorders. Dr. Guo was a recipient of the Harold M. Weintraub Award (2012), the Peter and Patricia Gruber International Research Award in Neuroscience (2012), and was recently named a Yale Scholar in Neurodegenerative Research (2017) and the Klingenstein-Simons Fellow in Neuroscience (2018).