He is a senior investigator of the Thrombolysis in Myocardial Infarction (TIMI) Study Group, and over the past two decades has been the principal investigator for more than 10 international clinical trials in the area of heart attacks and prevention. Recent trials include PROVE IT-TIMI 22, which showed that "lower is better" for cholesterol and changed international guidelines, and CLARITY-TIMI 28 which showed that giving heart attack patients clopidogrel (Plavix) can prevent future heart attacks. Author home: Boston, MA.