He is associated with the Department of Physiology and Pharmacology and the Department of Immunology, Microbiology & Infectious Diseases. Simon did BioPharm Co-op positions and his PhD with Luke Janssen at St Joseph's hospital in Hamilton. Simon is focused on the regulation of innate immune signaling in the gastrointestinal tract in the context of acute and chronic inflammatory diseases. He is interested in how the intestinal epithelium and resident mucosal immune cells contribute to inflammatory disease pathogenesis in the gastrointestinal tract. As such he examines how inflammatory signaling is initiated in the cells of the intestinal mucosa and how these event can be modulated by various immunomodulatory factors including antibiotics and environmental factors.