Moore studies neural mechanisms of visual-motor integration and the neurophysiological basis of cognition (e.g. visual attention, visual awareness, and working memory). This research involves the study of the activity of single neurons in visual and motor structures within the primate brain and tests of how perturbing that activity affects neurons in other brain structures as well as how it affects the perceptual and motor performance of behaving animals. His laboratory is also driven to develop more powerful and more causal approaches to systems-level neurobiology. He is the recipient of the National Academy of Sciences 2009 Troland Award and was an Alfred P. Sloan Fellow.