For the doctoral research, he joined Institute of Microbial Technology, Chandigarh, in 2004 to do research in the field of Bioinformatics. After completing his interdisciplinary education in life science and computational science, he moved to Case Western Reserve University, Cleveland, OH, USA to acquire post-doctoral training from 2010 to 2012. In 2012 he returned to join as a research scientist at the International Centre for Genetic Engineering and Biotechnology, New Delhi. He has been a visiting assistant professor at Olin College of Engineering from Jan-May 2017. Dr. Datt is actively involved in development and implementation of project-based courses at Ahmedabad University.