He has been collaborating with biomedical and life science researchers for the past six years to create Semantic Web informatics solutions for ontology-driven data integration, services-based scientific workflows, provenance metadata management, and knowledge discovery. His research has led to creation of three publicly available biomedical ontologies listed at the National Center for Biomedical Ontologies; a data exchange standard, called GLYDE, for the glycoproteomics community; and a framework for provenance management with applications in biomedicine, sensor networks, and scientific workflow engines developed by the University of Manchester, UK (Taverna) and Microsoft Research (Trident).