He obtained his PhD from ETH Zürich under the supervision of Isabelle Mansuy before conducting his postdoc at MIT under the guidance of Li-Huei Tsai. A main research focus of his lab is how long-term traumatic memories can be overcome. To answer this question, the Gräff lab uses mouse behaviour in combination with brain circuit and molecular analyses. Particular focus is paid to the emerging field of neuroepigenetics. Epigenetic mechanisms are at once dynamic and stable, and thus harbour the potential to better explain the molecular processes that govern learning, memory and memory loss. In extension, because epigenetic mechanisms are also amenable to pharmacological intervention, they might constitute a novel angle on how to counteract memory loss and resilient traumatic memories.