Using an integrated systems physiology approach, Prof. Menzies’ lab examines organ or stem cell energy metabolism in aging and age-related or neuromuscular diseases. His lab is particularly interested in mechanisms that control the balance of cellular NAD+ levels, an energy-signaling metabolite, for the maintenance of energy homeostasis. His most recent work revealed the role of NAD+ metabolism in stem cell health and longevity, along with the decline in muscle health in muscular dystrophy.