He has received a one-year Pilot Award to evaluate the use of a zebrafish system to study angiogenesis and lymphangiogenesis in LAM. Dr. Handin has developed a technique to study angiogenesis (development of blood vessels) in other cancers by injecting tumor cells into developing zebrafish embryos. His goal is to determine whether using this technique with cultured LAM cell lines will induce blood vessel development, as well as lymphatic development (lymphangiogenesis), and whether blocking lymphatic or blood vessel production prevents LAM tumor growth.