Mikulich's research has focused on longitudinal data analysis, specifically aspects including growth curve modeling, covariance and error structure determination, and linear and nonlinear mixed model analysis. Currently the Director of Biostatistics for the Division of Substance Dependence at UCHSC, Mikulich serves as co-investigator and biostatician on multiple other grants investigating aspects of substance use and comorbidity, including the ClinicalTrials Network. She has developed and managed large databases for more than 10 years and has extensive experience in the development of computer algorithms for providing clinical summaries and generating phenotypes.