His research focus centers on the mechanisms leading to autoimmune disease, with an emphasis on disorders that are diagnosed and mediated by autoantibodies. Work from his laboratory has contributed toward understanding the mechanisms of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Anti-Phospholipid Syndrome, Felty’s Syndrome and Sjögren’s Syndrome. His lab works on recombinant and monoclonal antibodies, chimeric antigen receptors, B cells, T cells and neutrophils. The lab searches for connections between individual protein or nucleic acid autoantigens, their post-translational modifications, immune activation, inflammation and specific disease manifestations.