She completed her medical degree and specialty training in medical oncology at the University of Messina and the Regina Elena Cancer Institute in Rome, Italy, and her doctoral and post-doctoral research training at the Dana-Farber Cancer Institute. Priolo's research interests include patient-derived pre-clinical models of cancer and the links between genetics and metabolism in cancer. The Priolo lab studies cellular metabolic abnormalities that can be targeted therapeutically and used to improve diagnostics in Tuberous Sclerosis Complex (TSC)-associated tumors and mTOR-driven cancers.