He conducts research in computational molecular biology, and develops algorithms computational systems to analyse genomic data. Jérôme Waldispühl is a pioneer of crowdsourcing and citizen science in computational genomics. In particular, he is the co-creator of "Phylo", a citizen science game designed to help the analysis of genomes from multiple species. Since 2010, Phylo has been accessed and played by more than 300,000 web users from 193 countries. Jérôme Waldispühl is an advocate for fully open citizen science platform with "Open-Phylo". More recently, he released a novel scientific game "Ribo" for contributing to the analysis of RNA sequences.