Ambrosio is best known for her work with Victoria's Secret and was chosen as the first spokesmodel for the company's "PINK" line. Ambrosio is currently one of the Victoria's Secret Angels and has modeled for brands such as Next, Armani Exchange, Christian Dior, and Ralph Lauren. Ambrosio serves as an ambassador for the National Multiple Sclerosis Society. Ambrosio was also selected by AskMen.com as Number 2 out of the "Top 99 Most Desirable Women of 2008". In 2012, she came in 6th on the Forbes top-earning models list, estimated to have earned $6.6 million in one year.