Research focuses on predictive data science, novel computing methods and a variety of their applications, such as natural language processing (NLP) & text mining, ultra-high dimensional "Omics" data analytics, data mining on wearable devices for health, privacy-preserving data mining in healthcare informatics, and big data infrastructure on bioinformatics. Besides his independent research and teaching, Dr. Li also collaborates with biomedical investigators, specifically, applying bioinformatic machine learning to analyze NGS and other high-throughput biomedical research data.