He completed his clinical training at the University of Munich. During a research fellowship at The Ohio State Comprehensive Cancer Center (Columbus, OH, USA) under the mentorship of Clara D. Bloomfield and Guido Marcucci, he developed a strong interest in translational research, mainly focusing on leukemia genetics. As a clinician-scientist, his current research interests are centered around understanding the genetic basis of myeloid neoplasms, and developing novel diagnostic tools, prognostic and predictive biomarkers, and ultimately more effective treatment approaches for patients with leukemia. Dr. Metzeler has co-authored over 50 scientific publications.