Dave is a molecular/cell biologist with expertise in signal transduction research. He has established an in vitro model systems research program in the Center to investigate the mechanisms of acute kidney injury (AKI) at the molecular and cellular level. These systems serve as stand-alone tools for discovery as well as support and compliment the established animal models in the Center. His current area of focus is on elucidating the roles and functions of the early AKI biomarkers IGFBP7 and TIMP2 in human kidney epithelial cells of proximal and distal tubule origin.