She has appointments in Psychology, Biology, and the Neuroscience Graduate Diploma Program, and is a member of the Centre for Vision Research and the York University Autism Alliance. Hoffman received her PhD in Neuroscience in the lab of Bruce McNaughton at the University of Arizona, with a project that pioneered high-yield, multi-site recordings of neural populations in the macaque. In her post-doctoral fellowship with Nikos Logothetis at the Max Planck Institute in Germany, she compared multi-site recordings with non-invasive imaging techniques during perceptual tasks. Hoffman's lab is now focused on discovering the mechanisms of plasticity in neural ensembles during perception and memory. Hoffman has been awarded by the Alfred P. Sloan Foundation, the Krembil Foundation, and received new investigator awards from the Ontario Ministry of Research and Innovation, and the Alzheimer's Association.