Francesca Fallarino’s reseach focus is on the study of the specific mechanisms involved in immune regulation. In this field, she has greatly contributed to the subject of immune tolerance, providing evidence that: (a) tryptophan catabolism in tolerogenic dendritic cells can exert profound immunoregulatory effects on T lymphocytes as well as on otherwise immunostimulatory dendritic cells (DCs); (b) kynurenines, the products of tryptophan catabolism, can regulate neuroinflammation and in autoimmunity through the activation of specific receptors.