She has demonstrated that regulation of Rac1 and RhoA activity in endothelial cells contributes to lung endothelial barrier integrity. In this symposium, Dr. Birukova will elucidate new mechanisms by which the RhoA/Rac1 balance is disrupted during the development of lung injury and develop novel therapies to restoring the RhoA/Rac1 balance and improve the lung repair and remodeling.