Doe studied sexology for Advanced Study of Human Sexuality. For eight years ending in 2014, Doe had taught a human course at University of Montana. In 2013, video producer Hank Green partnered with Doe to create "Sexplanations", a video series explaining sexual topics. Doe's work on Sexplanations follows the precedent set by producer of Sex +, another sex ed show on YouTube. In March 2015 Doe received attention for a YouTube video she uploaded to her personal "DoeEyes" account addressing an over-eager boy pursuing her daughter. Lindsey Doe's channel on YouTube Lindsey Doe at the Internet Movie Database