The goals of his research are to identify common pathways that are disrupted across various forms of Charcot-Marie-Tooth disease and to identify therapeutic targets that can ultimately lead to the development of treatments. His current studies focus on how mutations in the cation channel TRPV4 and the mitochondrial protein mitofusin2 (MFN2) lead to axonal forms of Charcot-Marie-Tooth disease. Dr. McCray's research uses a combined strategy of analyzing cultured cells, primary neurons, mouse models, and Drosophila models to elucidate pathways important in the pathogenesis of neuropathy. His earlier studies explored the axonal trafficking protein Rab7 lead to a subtype of Charcot-Marie-Tooth disease. ...read more