He received his PhD under the supervision of Dr Philippe Gros at McGill University working on the genetic basis of neural tube defects in mice. For his postdoctoral training, he first worked in Andy McMahon’s lab at Harvard and identified members of the mouse Hedgehog gene family, and then moved to Alex Joyner’s lab at the Skirball Institute in New York where he began his studies on the regulation of Sonic hedgehog (Shh) transcription. Current research in his lab at UPenn focuses on the temporal and spatial dynamics of Shh expression and function during vertebrate central nervous system development, including the elucidation of pathogenic mechanisms underlying congenital brain anomalies caused by Shh misregulation."