She is actively involved in basic science and clinical research, and her main research interests include the role of lipid metabolism in the etiology of diabetes and genetic causes of beta cell defects. In 1999 she received a Career Development Award from the Juvenile Diabetes Research Foundation International, and in 2000 she received a research grant from the same organization. Dr. Wyne has contributed many articles to the medical literature and lectures extensively on lipid metabolism and diabetes treatment. She is actively involved in patient care.