Scott received his Ph.D. in Dr. Rick Woychik's lab at the Oak Ridge National Laboratory where he cloned and molecularly characterized a classical coat-color gene in the mouse called the agouti locus. As a postdoctoral fellow in Dr. Terry Magnuson's lab at Case Western Reserve University, Scott knocked out the mouse BRG1 catalytic subunit of SWI/SNF chromatin-remodeling complexes and demonstrated that it is required for mammalian development and also functions as a tumor suppressor. As a PI, he has continued to develop and utilize mouse models of development and disease. Currently, his lab is particularly interested in identifying gut microbiota and microbial metabolites that influence colorectal cancer progression and elucidating their mechansims of action.