Sangastiano is known for her realistic portraits of sideshow performers and is one of the leading sideshow banner painters in the United States. Her work plays an important documentation role in the decaying theatrical genre of the American sideshow and its adaptation to an ever-increasing technological and mediated world. Exhibitions include Side Show, Yale School of Art; Amazing Marvels, Off Rhode Gallery in Washington D.C., Wide Open 2, curated by Nathan Trotman, Associate Curator, Solomon R. Guggenheim Museum of Art, BWAC, New York; Under the Big Top: The Fine Art of the Circus in America at the Robert Hull Fleming Museum, a commissioned outdoor bannerline installation for the Shelburne Museum’s Circus Day in America, and the Tate Modern, London.