His work spanned from randomized clinical trials for the prevention of preeclampsia with the use of L-arginine and antioxidants to fundamental mechanisms behind rupture of the fetal membranes. Dr. Vadillo-Ortega has developed a multidisciplinary and translational medicine approach to the study of pregnant women. He has published 160 papers on different aspects of the study of pregnancy diseases. He was a Professor at the largest and more recognized School of Medicine in Mexico, teaching basic sciences to medical students. He has mentored the thesis of 50 post-graduate students at the level of Medical Speciality, Master Degree and Ph.D. studies. Dr. Vadillo-Ortega has acted as a research official at several public and private institutions.