His work explores new modes of design and planning in light of reciprocal relationships between contemporary urbanization, infrastructural networks, and large-scale anthropogenic landscape change. Currently, the primary loci for these investigations are the “Four Coasts” project, an examination of the anthropogenic manipulation of sediments in four coastal regions of North America with the Dredge Research Collaborative (co-founded by Holmes), and design research on hydrological control infrastructures in south Florida, supported by the Graham Foundation for Advanced Studies in the Fine Arts. Prior to joining the University of Florida, he practiced landscape architecture with Michael Vergason Landscape Architects and taught in Virginia, Louisiana, and Ohio.