He also holds secondary appointments in the Department of Bioengineering in the School of Engineering and McGowan Institute for Regenerative Medicine. His current research focus is in the areas of mathematical modeling on health related topics, information integration, data analytics, health IT system development, and comparative genomics. Zhou's research goal is to provide computational methods and tools to facilitate high quality and low cost healthcare services. He is active in professional and scientific societies. He is a professional member of AHIMA, AMIA, and ACM. Zhou serves as a reviewer for books, conferences, journals, and state and federal funding agencies.