He is a Micheal Smith Foundation for Health Research Career Investigator. Dr. Shah's work focuses on characterization of cancer genomes for determination of pathogenic driver mutations in cancer subtypes and measuring and quantifying tumour evolution. His work is in the field of computational cancer genomics and involves development of statistical models and machine learning algorithms to interpret next generation sequence data for defining mutational landscapes and quantifying clonal evolution in ovarian and breast cancers. His recent work describing new cancer genes in ovarian cancer has been published in the New England Journal of Medicine and his work describing mutational evolution in breast cancer has been featured in Nature.