She studied at Folkestone and Dover School of Art, and at the Royal College of Art. All of her work is centred on painting and drawing. Wylie represented Great Britain in Women To Watch, National Museum of Women in the Arts, Washington D.C, 2010. Her first retrospective exhibition was held at the Jerwood Gallery, Hastings, 2012, and was followed by her BP Spotlight exhibition at Tate Britain, 2013, which led to museum shows in Philadelphia; Tonsberg, Norway; Wolfsberg, Germany; Tal R’s Project Space, Copenhagen; and the Douglas Hyde Gallery, Dublin. In 2011, she was given the Paul Hamlyn Award and in 2014, she won the John Moores Painting Prize.