Louis. She received her PhD in 2010 from Yale University where she studied protein – protein interactions and protein engineering. She then joined James Shorter’s laboratory in the Department of Biochemistry and Biophysics at the University of Pennsylvania as a postdoctoral fellow. There she developed techniques to re-engineer the protein disaggregase, Hsp104, to counter the misfolding of TDP-43 and FUS implicated in ALS. She has shown that these agents can directly solubilize TDP-43 and FUS aggregates and restore their proper localization. She was awarded a postdoctoral fellowship from the American Heart Association as well as a Target ALS Springboard Fellowship.