Dr. Simone completed his undergraduate training at the University of Pennsylvania and earned his medical degree from the Perelman School of Medicine of the University of Pennsylvania. Following completing his internship in internal medicine, he completed residency training in radiation oncology at the National Cancer Institute, National Institutes of Health. Dr. Simone treats patients with mesothelioma, lung cancer, and other thoracic malignancies with photon and proton radiation therapy and with photodynamic therapy. He performs clinical and translational research investigating the treatment of mesothelioma and other thoracic malignancies with photodynamic therapy, and he conducts clinical research investigating the use of radiation therapy as part of multi-modality therapy for mesothelioma and non-small cell and small cell lung cancers.