Her research is focused on gynecologic malignancies, and she is the Principal Investigator of several clinical trials for ovarian and cervical cancer. These trials include novel drug development as well as tissue banking and quality of life studies within ovarian cancer. Dr. Matulonis also has a strong interest in ovarian cancer translational research projects, two of which involve the molecular profiling of ovarian serous cancers as well as identification of oncogenic, targetable mutations in ovarian cancers.