His research and surgical techniques have helped to establish UCLA as one of the highest volume centers for transoral robotic surgery (TORS) and transoral laser microsurgery (TLM) in the western United States. Mendelsohn's clinical success has allowed UCLA to qualify for multi-institutional randomized control trials studying the role of minimally invasive surgery in the treatment of tonsil and tongue carcinoma, which serves as a major scientific endeavor. In addition to studying advances in surgical treatment of throat cancer, his current research efforts also include improving voice function following laryngeal cancer treatment and uncovering surveillance strategies for early detection of throat cancer.