His clinical work has been instrumental in establishing the use of lorazepam as first line treatment for the catatonic syndrome. His research in neuroimmunology and neuropsychiatry has focused on macrophage-endothelial cell interaction with resulting publications in the Journal of Immunology, Immunology Today, Endocrinology, the American Journal of Hematology and in various neurology and psychiatry journals. Recently, he has been studying the important role brain evolution may play in the human spiritual imperative. He is a co-director of the Harvard Medical School course on Spirituality and Medicine.