Dr. Shioda?s research focuses on the way in which toxic substances in the environment affect the regulation of gene function in the mammalian cells, including stem cells and germ cells. That work has included the use of cutting-edge technologies of genome analysis to determine how environmental endocrine disruptors and other toxins act at the molecular level to disrupt genetic and epigenetic programming in human and mouse cells in live bodies and cell cultures. His laboratory is also exploring the molecular mechanisms of breast cancer resistance to certain anti-estrogen therapies. Dr. Shioda received his MD license in Japan and earned a PhD in biochemistry from Hiroshima University Graduate School of Medicine.