Dr. Sonis is actively involved in translational and clinical research in supportive cancer care, radiation-injury, and genomics. His research focuses on understanding the fundamental biological processes that lead to damage and inflammation at mucosal surfaces. His specific expertise is mucosal toxicities following cancer treatment regimens, identifying the genetic factors that predispose patients to toxicities, and developing and testing effective toxicity interventions. His research group has identified the biological pathways that are associated with injuries of the GI tract, skin, and lung, cancer regimen-related cognitive dysfunction and cancer-related fatigue.