His research focuses on histone methyltransferases in tumor suppression. Abnormal diet causes one third of cancer deaths in the United States, and it remains one of the important problems of cancer research. Huang's group discovered tumor-suppressive functions for a class of enzymes, the histone methyltransferases, that requires dietary methyl intake for activity. His group is examining the hypothesis that abnormal diet, typically high in meat and low in vegetables and fruits, causes cancer by inhibiting histone methyltranferase class tumor suppressors.