She specializes in treating mood, anxiety and behavioral disorders using evidence-based individual, family, and group psychotherapeutic approaches with gender- and sex-diverse youth. Dr. Chen regularly staffs the multidisciplinary Gender Development Clinic for transgender, gender-diverse, and gender questioning youth and the Sex Development Clinic for youth with medical conditions marked by differences of sex development. She is actively involved in the clinical and academic endeavors of the Pediatric/Adolescent Gender and Sex Diversity Fertility Working Group. Her research examines health behavior, mental health, gender identity development and clinical decision-making among gender- and sex-diverse children, adolescents, and youth adults and their families.