Spire-Oh received a J.D. from Hofstra University and a B.S. in Industrial and Labor Relations from Cornell University. Prior to starting her law practice, she was legal editor of the National Disability Law Reporter and the Disability Compliance Bulletin. Spire-Oh serves on the board for the Learning Disabilities Association of Florida, and on the State Advisory Committee for the Education of Exceptional Students, the Florida Partners in Policymaking 2012 Class, the Florida Association of Special Education Attorneys, and numerous other groups.