With globe trekking international relief workers for parents, Dr. Malepati was raised in an environment that had a strong emphasis on humanitarian pursuits. He went on to study, perform research, and teach at over 15 universities nationally and internationally. At the age of 25, Dr. Malepati was the youngest faculty member at Georgetown University School of Medicine. He is a former fellow of the National Institute for Health Care Management, where his research focused on how flaws in the design of health care systems contribute to patient disease and public health problems. Dr. Malepati has worked under grants from the National Institutes of Health and the National Science Foundation.