His main research areas of interest include signal processing for wireless communication systems with an emphasis on the physical layer aspects of free-space, underwater, and indoor visible-light optical communications. So far he has served as the Technical Program Committee member for more than 20 international conferences and workshops in the communications area. Also, he was the Vice Chair of WG2 of the FP7 IC1101 COST Action on optical wireless communications. Dr. Khalighi is the recipient of the Scientific Excellence Award from the French Ministry of Research and Higher Education for the period of 2009–2017.