He has established several renowned aesthetic medical centers across Italy. Dr De Gregorio graduated at Perugia University, pursued a Postgraduate University Masters in Aesthetic Medicine and Surgery at the University of San Marino and "La Sapienza" of Roma, and obtained a position as Associate Professor of Aesthetic Medicine and Surgery from 2009 to 2011 at the University of San Marino. He is an active faculty member of the International Society of Surgical Anatomy where he teaches clinically oriented anatomy through detailed cadaver dissections. He divides his time between his teaching commitments in Nice, France, and his busy aesthetic medicine and surgery practices in Perugia, Roma, Ancona, Bologna, Mantova, and Verona, Italy.