Dr. Naini's research interests include molecular pathogenesis of neurodegenerative diseases and primary CoQ defeiciency. In collaboration with Drs. Hiroshi Mitsumoto, Michio Hirano, and Serge Przedborski, Dr. Naini studies patients affected with amyotrophic lateral sclerosis (Lou Gehrig's Disease) harboring mutations in their Cu/Zn superoxide dismutase gene. In collaboration with Drs. Savatore DiMauro, and Michio Hirano, he also studies patients with mitochondrial encephalomyopathy due to primary CoQ deficiency.