The Duvall Advanced Therapeutics Laboratory (ATL) specializes in design and application of novel drug delivery systems based on the creation of smart polymer technologies. Goals include delivery of biological drugs such as proteins and nucleic acids into specific cell types, and targeting of drugs to sites of inflammation and tissue remodeling. His lab is also developing polymers that can provide controlled long-term drug release. Each system involves development of finely tuned polymers that release their drug payloads in response to stimuli such as pH and temperature change. These new approaches are being applied clinically to increase the longevity of vascular grafts, promote healing of chronic wounds, and improve breast cancer therapies.