He is married to Suzy Shuster, college football sideline reporter for ESPN on ABC. He wrote the book Total Access which was published in 2007. Before working for the NFL Network, Eisen worked for ESPN. He was part of a duo and became well known for his humor, and provided interviews during the Home Run Derby. Eisen was also the host of ESPN's reality series, Beg, Borrow & Deal. For ESPN Radion, he served as a hot of Major League Baseball and as a guest host on The Tony Kornheiser Show and The Dan Patrick Show. Outside of the world of sports, Eisen hosten the ABC show Domino Day.