His research interests include cropping systems analysis, crop simulation modeling and digital agriculture. His research program focuses on deeper understanding Genotype x Environment x Management interactions, adding mechanistic algorithms into crop models to better simulate soil-plant-atmosphere processes and expression of genotypes in the field, and on developing web-tools to disseminate research results in real-time to stakeholders. Archontoulis' research group uses field experimentation and computer simulation modeling to predict impacts (e.g., yield forecasting, the FACTS project), explain causes and design strategies to improve production and environmental performance of U.S. Midwestern cropping systems under current and future climate.