After being "discovered" by Will Ferrell in his independent feature debut, 2006's The Foot Fist Way, McBride has appeared in several films including Pineapple Express, Tropic Thunder and, most recently, Jason Reitman's Up in the Air. In Eastbound and Down, McBride plays washed-up major league pitcher, Kenny Powers (McBride), who lives with his brother and works as a coach at his old Junior High School.