After working for other design offices in San Francisco, she founded Lillie Design in 2003. Lillie Design specializes in educational interiors projects and interiors for residential clients. She has also worked on large institutional projects such as San Francisco City Hall and Berkeley Civic Center. Lillie Design has worked with many non-profit organizations to create spaces that reflect their character and work. From 1997 to 1998, Alissa served as the Director of 2AES/Center for Critical Architecture in San Francisco. This non-profit sponsors an architectural lecture series for the public and competitions to further design interest and integrity in the area.