He has been working on endoribonucleases and their role in the control of mRNA turnover and gene expression as it relates to cancer since 1996. Before joining the University of Northern British Columbia in 1998, Dr. Lee spent his postdoctoral research work at the Ontario Cancer Institute, BC Cancer Agency, and McArdle Laboratory for Cancer Research, University of Wisconsin—Madison. Dr. Lee obtained his Ph.D. from Flinders University in 1992 and his B.Sc. with first class honors from the University of New South Wales in 1988, both in Australia. Using biochemical purification techniques, he fortuitously discovered APE1 as an endoribonuclease that cleaves c-myc mRNA in vitro and regulates c-myc mRNA level and stability in cells.