His research focuses on skeletal muscle nitric oxide (NO) to determine if it enables skeletal muscle to communicate with other organs, and if this communication mediates some of the systemic benefits of exercise. NO is a biomarker of healthy skeletal muscle and NO signalling is known to be important in the cardiovascular, immune and central nervous systems. Healthy skeletal muscles express more neuronal NO synthase (nNOS) whereas unhealthy muscles have less nNOS or defective NO signalling.