His lab studies how genes influence the structural and functional properties of brain circuitries critical for perception, cognition and adaptive aspects of human emotions. To better understand the neurogenetic influences on emotions, his group examines how the emergence of affective disorders are linked to genetic signatures of maladaptive brain functions. His research is integrative in that he: 1) analyzes normal behavioral, diagnostic and environmental phenotypes of affective states, 2) applies anatomical and physiological neuroimaging measures to analyze emotionally tractable brain states, and 3) employs genetic and molecular analyses of adaptive and maladaptive brain-mediated affective functions across the human developmental spectrum.