She holds secondary appointments in the Schools of Nursing and Public Health, and received a doctorate in health system management from Tulane University. Experience as a nurse and health system executive inspired Goeschel to create the Michigan Keystone Center, which she led from its inception in 2003 until joining Hopkins in 2006. Her work has been published in the New England Journal of Medicine, JAMA, The Lancet, Health Affairs, Health Services Research, and BMJ, and her current research includes studies aimed at reducing infections in high-risk patient populations.