He is originally from Southeast Michigan, attending the University of Michigan (Ann Arbor, MI) for his undergraduate studies and Wayne State University School of Medicine (Detroit, MI) for medical school. He formerly served as the Chair of the Association of Residents in Radiation Oncology (ARRO) Executive Committee and was a Resident Representative on several ASTRO committees. Dr. Mancini is the skin cancer, melanoma, and palliative moderator for radiation oncology.