At MIT’s Media Lab he has helped to develop interactive musical tools, such as Hyperinstruments that use artificial intelligence to augment musical expression and creativity. His wide-ranging output includes orchestral, vocal, chamber and solo pieces, as well as five operas. Machover's music has been performed and commissioned by the Los Angeles Philharmonic, the San Francisco Symphony, the Centre Pompidou, London Sinfonietta, Houston Grand Opera, Lincoln Center for the Perfoming Arts, Ensemble InterContemporain, Ensemble Modern, and the Tokyo String Quartet. Tod Machover was nominated as a finalist for the 2012 Pulitzer Prize for his opera Death and the Powers.