Grubbs has released twelve solo albums and is known for his cross-disciplinary collaborations with writers such as Susan Howe and Rick Moody, and with visual artists such as Anthony McCall, Angela Bulloch, and Stephen Prina. He was a member of the groups Gastr del Sol, Bastro, and Squirrel Bait, and has performed with the Red Krayola, Will Oldham, Tony Conrad, Pauline Oliveros, and Loren Connors, among many others. In his recent publication Records Ruin the Landscape: John Cage, the Sixties, and Sound Recording (Duke University Press, 2014) he studies the role that sound recordings play in representing experimental music of the 1960s.