He leads a laboratory whose work focuses on signaling in the immune system and the host processes exploited by the HIV-1 virus. His lab is particularly interested in control of apoptosis, autoimmunity, angiogenesis, retrovirology, and blockade of HIV-1 infection. He has worked to develop methods of advanced flow cytometric analysis (FACS) of phosphoproteins in single cells and dominant effector genetics. He has developed a range of FACS assays, cDNA and peptide expression systems using viruses, and single-cell genetic selections to study pathways of interest.