Previously, he was a faculty member at the Albert Einstein College of Medicine and was a postdoctoral researcher at the University of California, Irvine and the National Institutes of Health. His graduate training was at the Pasteur Institute in Paris. Fidock heads a malaria research lab focused primarily on defining the genetic and molecular basis of drug resistance and the mode of action of antimalarial drugs, as well as on investigating lipid metabolism in blood- and liver-stage parasites.