His favored medium is a large-format, 8" x 10" camera, which records a uniformly high level of detail and tone. Wylie works by establishing a relationship to a site through repeated visits and producing images that delve deeply into the interconnected natural and cultural history of these places. His past projects in the United States include documenting Colorado’s Cache la Poudre River (where he walked 150 miles from the mouth of the river on the eastern plains to its headwaters at the Continental Divide) and more recently, his 2010 project along the two-lane Route 36 as it cuts across Kansas. He also works extensively in Italy, where he has photographed the famous marble quarries of Carrara and the industrial landscapes of Tuscany and Rome.