Two major questions that Konstantin Khodosevich’s lab addresses are: how diversity of interneurons is established during brain development and how disturbances in generation and maturation of interneurons contribute to decline of cognitive abilities in mammalian brain? His lab aims to identify intrinsic transcriptional programs and extrinsic modulation that are required for specification, positioning and wiring of different types of interneurons. The lab uses both in vivo and in vitro approaches, thus studying gene expression pattern in neurons during development in vivo and reproducing in vivo differentiation programs for generation of neuronal subtypes in vitro. Mechanisms of function for genes that regulate neuronal differentiation and maturation are studied in details in vivo in mouse models and in vitro in human cell cultures. 最后更新于 2017年1月05日 星期四 09:05