Her research program centers on understanding the mechanisms of tuberculosis (TB) pathogenesis and host immunity to infection in mice and humans. TB remains an enormous global public health challenge and developing new vaccines and immune-therapeutics for TB, are important goals of her research efforts. She also conducts translational patient-based research to study human immunity to latent and active TB in metro Atlanta and aims to identify diagnostic biomarkers of infection and disease. http://www.vaccines.emory.edu/faculty/rengarajan_jyothi.html