Over the years, Dr. Hong has lead his research team to study the lipid-mediator regulation of the regenerative functions of mesenchymal stem cells and adipose derived stem cells in diabetic wound healing, acute kidney injury, and serve burn injury. By using their unique mass-spectrometry based platform of lipidomics, they have found several novel lipid mediators that can promote the regenerative function of stem cells. They has published multiple research articles on the interplay of lipid mediators and stem cells and their potential to repair injury and heal chronic wounds. Dr. Hongs team is currently studying mechanism of action of novel endogenous lipid mediators on stem cells in diabetic wound healing.