Louis and has a joint appointment in the Division of Biostatistics, Washington University in St. Louis, School of Medicine. His methodological research is in the areas of statistical computing for massive data, Bayesian regularization, bioinformatics, longitudinal and functional data analysis and psychometrics. His applied research involves statistical analysis of data from anesthesiology, genomics and cognition. He teaches a wide range of statistics courses, including mathematical statistics, Bayesian statistics, linear models, experimental design, statistical computation, and nonparametric statistics.