His research interest is the development of novel therapies to treat pancreas cancer. He directs the clinical pancreas cancer program, which utilizes an array of clinical trials to attempt to advance pancreas cancer therapy. He is also a member of the developmental therapeutics team. This affords him the opportunity to treat patients with cutting edge therapies. In addition, he directs a translational research lab focused on utilizing pancreas cancer biology to develop novel molecular based cancer therapies. Dr. Weekes is an active member of the Pancreatic Cancer Research Team (PCRT), American Society of Clinical Oncology (ASCO) and the American Association for Cancer Research (AACR).