She also holds a joint appointment in University Hospitals-Case Comprehensive Cancer Center. Zhang's expertise ranges across the synthesis and characterization of polymers and nanomaterials, nanotechnology, tumor immunology, and immunotherapy in the treatment of cancer. Her primary research interest is to apply polymer materials to the design and development of novel nanoparticle systems for multifunctional applications, including gene drug delivery, biomedical imaging, and bio-energy systems (e.g., bio-fuel cells).