Her current research focuses on biomedical HIV prevention strategies, specifically clinical trials of preventive HIV vaccines. Particular interests include assessing combination biomedical prevention strategies such as vaccines together with oral and topical prophylactic antiretrovirals; and evaluating host factors influencing immunologic and virologic course of HIV disease and response to vaccination in study participants. As an investigator in the National Institutes of Health sponsored HIV Vaccine Trials Network (HVTN), a multicenter organization whose mission is to develop an effective preventive HIV vaccine, she has been involved in the development and implementation of several international and national protocols.