Evening star. [volume] (Washington, D.C.) 1854-1972, 1963-10-16
Cancer Tests
OF KrebiOzen
Register Zero
By WILLIAM GRIGG
Star staff Writer

Dg WILLIAM GhAaVO
Star STAFF Writer
Investigation Of the best"
504 cases Of Krebiozen's use In
several thousand cancer pa
tients has found no objective
proof that they benefited from
the treatment.
Thus, in an announcement
released for publication today,
the National Cancer Institute
has marked the case for a Gov
eminent test of Krebiozen
closed"
The announcement was dis
cussed with reporters in a
background conference late
yesterday. Then Dr.. Stevan
Durovic. the developer Of the
product. and DR.. Andrew c.
Ivy, its scientific sponsor, held
their own press conference. DR..
Ivy charged there has been an
atmosphere of prejudice" In
the reviewing of Krebiozen.
In response to questions, Dr..
Ivy said he Is still sending Kre-
biozen to England for an Amer
lean patient there. Interstate
shipment Of Krebiozen is illegal
because its hackers have not
filed a proper application for
such distribution with the Food
and Drug Administration.
Attorneys Views
A Food and Drug Admin
istration attorney said later
that as he understands current
FDA regulations. any shipment
outside Illinois, where Krebiozen
is made, is illegal.
A spokesman for FDA had
e earlier made clear that the
agency is still studying the dis
tribution of Krebiozen and
other aspects of its handling
to see if these have been legal.
The 504 cases of Krebiozen's
use were supplied to the Gov
eminent by the drugs hackers.
They were selected by the pro-
motors of the product from
several thousand cases as the
best demonstrations of its eff
fectivenesS.
FDA then tracked down the
hospital records involved, the
records of the patients doctors
and the recollections Of the pa
tents families or. in some
cases. the recollections Of the
patients themselves.
Some Temporary Reduction
Of the cases checked, IS had
possible temporary regressions
Of their tumors, although even
this is doubtful.
But two Of these-or two
out of the entire 504-had
objective repression Of their
cancers. One of these was q
boy treated at age IL.
ct is this boy, DR.. Ivy later
said, who is now a student at
oxford University and is re-
ceiving Krebiozen there)
DR.. T. Phillip Wakes. asso-
ciate director of the National
Cancer Institute IN Bethesda,
said these results were about
what you would expect in any
random group of 500 or so pa
| tents.
He explained that a certain
number of cancers regress
mysteriously on their own.
Some entirely disappear.
Largely Breast Cancer
He told several reporters that
the largest group of cancers in
the 504 were breast cancers. He
said it has been shown that
even without treatment, % per
cent of the victims Of breast
cancer live five years and S per
cent 1--we 10 years or more.
The 504 cases were treated
from 1851 through 1862.
The study Of the cases was
begun before the Food and
Drug Administration an
nounced its finding that the
material C al lee Kr e bioZen
proved on analysis to be a COM
mon chemical called creatine, a
substance in great quantity in
both healthy and diseased
bodies.
The scientists studying the
504 ca es unanimously con-
cluded that Krebiozen possesses
no anticancer activity. Indeed,
said DR.. Kenneth Endicott, d.
rector of the National Cancer
Institute. "aS far as we can tell
it has no effect-period."