davidaulloa/AmericanStories huggingface dataset:
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

immediate withdrawal of a drug
and give the company a chance
to fight it out at q hearing
later.
The legislation halfway
through Congress would meet
the problems shown by MER /29
on a number of grounds. Had it
been on the books when the
young doctor grappled with the
drug, he would have had $50
days rather than so days to
reach his decision, plus another
l20 days if the new drug appli-
cant sought a hearing on an ad-
verse ruling.
In addition. the usefulness of
the drug would have had to be
established and the HEW Sec
Rotary would have been given
indisputable authority at his
discretion to regulate the ami
NAL testing and require that
investigation of reactions in
both animals and humans be
reported simultaneously to the
company and the FDA.
If the drug had gone on the
market, the Kefauver bill pro-
vides that advertising must
carry information on the drugs
side effects and its effective
ness thus alerting doctors more
thoroughly and the drug could
have been withdrawn when the
evidence of danger first ap-
peared.
One-man decisions on drugs
potentially affecting the health
of millions of people have been
a growing source of concern.
A former secretary of the
American Pharmaceutical As
ISOLATION advocated last week
the establishment of a Supreme
Court of Drug Evaluation" to
make final decisions on the
safety and efficacy of new
drugs.
The Kefauver bill makes an
indirect attack on one-man de-
cisionS as well as the problem
of pressures from industry.
At present, a new drug can
be cleared by default.
If FDA does not act to block
a drug it goes onto drugstore
shelves. Under the Kefauver
measure, positive action is re-
quired. Every decision to put a
new drug on the market must
be formally approved.
Since the actions would be
taken in the name of the HEW
Secretary. presumably he would
require a chain of written in
dorsements from FDA officials
that the drug will be effective
as well as safe.
Then. FDA would be acting
as a team and one young doc
tor would be neither subjected
to a barrage of industry pres
Sures nor pinpointed for blame
in decisions potentially affect
ing the health of millions.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

rell firm is located, CHANGED
to ride in a car pool with a
man who commented on the
warning letter issued by the
MezTen company. The man
said his wife had worked for
the company on its MER/ 29
animal research but quit.
An interview with the wife
prompted FDA officials to
become vitality interested in
the company's reports on its
MER/29 experiments with mon
keys. In the research done by
the company, monkeys were
considered crucial because, as
the company pointed out, they
were closer to humans than
rats and chickens. If monkeys
showed no side effects from
the drug, the company argued,
humans could be considered
safe.
After the woman told her
story, FDA officials decided to
pay a call on the company to
discuss the firms research data.
Two days after this unan-
nounced and almost unprece-
dented visit, the company told
FDA it wanted to withdraw the
drug.
There was one final flip to
the story Of MER/29.
On April 16, the company is
sued a press statement which
appeared in April II papers an
nouncing its withdrawal of the
drug. The statement said, how
ever. that continuing research
and clinical experience with the
drug has not established that
MER/29 is unsafe when used
as recommended"
In at least one newspaper &C
count, a Richardson-M erren Of
ficial was quoted as saying that
there is no particularly new
evidence" since the December
warning letter to motivate
withdrawal OF the drug
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26
Application Filed

1t was in this atmosphere of
assorted preSsures and opinions
that the Food and Drug Ad-
ministration received a new
drug application for MER %
in July. 1859.
The application went first to
q doctor in the Division of New
Drugs who resigned a short
time later. 1t was then assigned
to a doctor, then 80 years old,
recently out of his internship
and residency training in in
ternal medicine.
Without naming the doctor
Mr.. Harvey in his recent speech
to the bar association specific
ally put the responsibility for
clearing MER /29 on one man
by saying this new durg officer
allowed the drug to go on the
market.
The doctor, who shall be
called Doctor X, has since left
FDA to enter private practice
and was interviewed without
access to his records. On the
basis of his recollections, he
gave The Star this account of
his role in the clearance of
MER/29:
AS soon as the application
appeared on his desk, the COM
pany started contracting him
about the drug. His most fire.
quent contacts were with F.
Joseph Murray, director of
scientific relations of the Mer-
rell Co. Mr., Murray also fig
ured prominently among the so
contacts made by the firm to
DR.. Frances O. Kelsey and
others in FDA's Bureau of
Medicine in an effort to get
thalidomide approved.
There were many telephone
calls and several meetings, y
Doctor x recalled. 1T was OBJ
viouS the company was ex-
tremely anxious to get the
drug on the market. Some COM
panies brought very little pres
sure but this company liked to
keep the pressure on.
The American Medical AS
ISOLATION convention was COM
ing up and they we're anxious
to promote the drug at the con-
vention. I was getting daily
telephone calls"
The pressures on Doctor x
Drug industry preSSures on
Doctor X and other FDA med
ical officers were pinpointed
later in 1860 by an outside team
Of experts who investigated
FDA personnel and operations
and recommended to the Sec
rotary Of Health, Education
and Welfare that a reasonable
control be put upon the access
Of industry representatives to
FDA personnel considering &C
tons affecting industry"
But two years later nothing
had been done to shield the
medical officers. Assistant FDA
Commissioner Winton B. Ran
kin was quoted in a June, 1862,
drug publication as reporting
pressures by drug firms to get
quicker action had become
pretty general"
Doctor x was also suffering
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26
A Chance Meeting

Just as a chance look at q
British medical journal alerted
DR.. Kelsey to dig deeper into
thalidomide. a chance meeting
played a part in the ultimate
withdrawal Of MER/29.
A Food and Drug inspector
in Cincinnati, where the Mer-
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

from the pressure of time. IN
less he could find something
incomplete in the application
the method used by DR.. Kelsey
in Stalling on thalidomide-
he faced a 60-day deadline.
At the time MER/29 was
pending for clearance, Doctor
x considered himself solely re-
sponsible for the decision on
whether the controversial drug
should be approved.
The resting on the shoulders
of one man of so much respon-
sibility for drugs affecting mil
lions prompted a special COM
mittee of the National Academy
Of Sciences-National Research
Council to recommend later in
1860 that an advisory organ
ization of scientific and tech
nical experts should be estab-
lished to advise FDA on criteria,
procedures and policies.
Asked about the present
status of this formal recon-
mendation, Mr.. Harvey said
the recomme en- d e d advisory
board had not been established
but added that when we have
a problem, we do try to get
together a committee to advise
US" He said that no such
committee was asked for help
on MER /29.
AS far as Doctor x was con-
cerned, he had problem. Al
though company officials had
intimated on their first visit
to him that they were under
the impression his predecessor
had considered the drug ready
for release, Doctor x found he
had to start from scratch.
Il had no drug to compare
it with" he said. Nothing
gave a clue as to where to look
for toxicity adverse effects.
I recall talking with my super
visor. but he didn't advise on
whether to pass it or not to
pass it. He wasn't prone to do
that.
MY thinking was that here
was a drug purporting to lower
cholesterol. We were dealing
with a highly lethal disease
state - arteriosclerosis. This
drug might be helpful in dealing
with the No. killer of men,"
He said he was aware that
scientists at the National Insti-
tuteS of Health were concerned
that MER 20, in blocking the
formation of choleSterol, caused
a pile-up of a related substance
not normally found in man to
any material extent. He said
it didn't come out until later
that this substance, desmos-
terol, was deposited in the blood
much like cholesterol.
This would raise a question
Of efficacy-waS the drug USE
full for its intended purpose.
but that's a loophole in the law
that the Senate-passed Kefau-
YER bill and measures now
pending on the House side are
designed to plug. At present. |
FDA passes only on safety, not
on efficacy.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26
MER/29: Cho|esteroI Drug illustrates Problems

trials to eliminate further po-
tential areas of toxicity. He
does not recall how long it was
after he wrote that letter that
he cleared the drug. Re-
portedly, it was three weeks.
Il was in a state of indie
cision where little things would
have influenced me a great
deal" he said,
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26
Visit by Mintener

Presumably, the company's
position was conveyed to Mr..
Harvey by Bradshaw Mintener,
an assistant secretary Of HEW
in the Eisenhower administra-
ton. Mr.. Mintener is a men,
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

widely in medical journals.
Stories were being written
about the wonders of the drug
in newspapers and magazines.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26
NllllaasM
for Telephone Shopping and Services call $4,000

see and taste the delights
of the Waring BIendor and
Ice Crusher, created for
you in seconds by Miss
Davis and Miss Kyle.
The two units specially
priced as one for this % ~
demonstration week W.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

Use the Wong Bendor and together for COOL os drinks
Alone the Bendor chops crumbs gofes puees blends and mixes
make magic eftove delights Pyex Jar blends
hot cold foods Alone Ice Jet crushe oys of cubes in
30 seconds for drinks sood and many other special eots
wt-smoH Appliances Washington Chevy Chase.
Wheoton Pozo ind Corners
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-08-26

Demonstration Schedule, Monday
August 9th, through Friday the 3lst
Washington Store, IL noon TO 500
pm. Monday 1000 am. to 500 pm.
tuesday through Fridoy.
J Corners, MondoY, 400 TO 900 p.m.;
TuesdoX 1000 am. to 8 pm.
Wheofon Plozo, Wednesday, 1000
o.m. to loo P.m.; Thursday 400 am.
TO 800 pm. Friday, 500 to 900 pm.
Chevy Chose Store. Wednesday, 800
to 500 p.m.; Thursday, 500 10 900
pm. and Friday HOO ON. to
800 pm.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-06-13
Society-Home
New Dance Work Set BY UJA

cation has commissioned a
new work in an experimental
form: A dance narrative with
original choreography, mu-
sic and script.
This will be presented for
the first time as the program
highlight of the UJA Victory
luncheon. to be held at 1870
am. Monday at the indian
Spring Country Club.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-06-13

The recommendation Of the
Kennedy administration that
support for the creative arts
be undertaken at the conmu-
nifty level is finding activation
by women leaders of the
United Jewish Appeal.
On the suggestion of Mrs.
Elaine H. Fig, chairman of
the suburban won1en's diyi-
sion of the UJAs the organi-
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-03-15

These prices sss Until close Of business SofS Meteh w. 1852
Washington D. C. MARYLAND. Palmer Park. sE Heights. Tokoma Pork
hdon Heed sadsnsews corol Hills cophe Heights Marlboro, Bethesda
Silver Spring. Rockville oiosbVs lovrs VIRGINIA. Alexandra, ARaoa
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
STABLE PETS BARRED IN FLORIDA
Love Ne, Love Ny Dog-So KeIso Stoys Home

NEW YORK, Dec. 7 APP
A goat will be able TO have a
nice time, laying around soak
ing up the warm sunshine in
Florida this winter.
But II looks as II Mickey and
Cookie-not TO mention the
mighty Kelso-will get gypped
out Of a balmy vacation at
Hialeah. Mickey and Cookie
are dogs. mascots and close pals
Of Kelso.
Because OF a tick fever scare,
the Florida Racing Commission
has barred all stable pets at
race tracks-except goats. Per-
haps ticks shy away from
natural goat perfume.
Mickey, IL. and Cookie, 2,
keep Kelso happy. When Kelso
is happy, he wins races. When
he wins races. his owner, Mrs.
Richard c. DUPONT and his
trainer. Carl Hanford, are
happy, too.
Last Saturday ws a day OF
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
Curtice Bows Out
At Stanford Fete

PALo ALTO. Calf, Dec. Z
(APa. - Cactus Jack Curtice
bowed out officially as STAN
ford's head football coach last
night amid cheers of his play
ers al an awards banquet here.
"I'n always have the mem
DRY Of the great. second-half
comeback you fellows made
against CAL" he said, referring
to the last game he coached in
which Stanford topped Califor-
mia. 30-l3.
Curtice. 55, was fired No
vember 81 after compiling a
record Of IA victories and 36
losses for the Indians over a
five-year period.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
Star Staff Writer

Bill Pashe, George Washing
ton halfback who was drafted
18th by the New York Giants
last Monday, talked TO Giant
officials last night at the Du-
pont Plaza Hotel.
Pashe said he visited with
Tim Mara, secretary-treasurer
OF the club and Scout Emlen
Tunnel. Money was not dis
cussed but he was told that he
probably would be tried as q
defensive back II he signed.
Pashe said today he wants
10 talk with university off,
cials over the week end TO de-
termine what effect signing a
pro contract would have on his
athletic scholarship.
An All-Southern Conference
outfielder last spring. Bill has
used up his eligibility in base
ball but his scholarship extends
through the spring semester
He currently is taking graduate
work In secondary education.
Surprised by Selection
Pashe admitted he was sur
prised at his selection by the
Giants. II really hadn't
thought about pro football" he
said. but I'd like TO give II q
whirl."
Meanwhile, teammate Dick
Drummond, drafted In the 18th
round by the Chicago Bears. is
not expected 10 make a decision
until late spring. Drummond
has one year Of college eligibil-
fly yemaining and also is
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07

ing race for $500. Nickel Boy
improved with age and then
was claimed by his present
owner, Max Gluck, for $40, 900.
y = =
Gluck, the master Of Elmen-
dorf and former ambassador to
Ceylon, has profited most from
the "impossibly" bred gelding,
although all four Of the stables
he has run for have made
money with Nickel Boy.
If there are IL starters in
the Jennings, as expected,
Nickel Boy will be running for
first money of $18.947. And
Gluck will not be the only one
roofing for him. Blackburn, his
breeder, also would pick up a
Christmas gift" Of $3.50.
The observation-disclosures
Jennings is one of the new
Maryland-bred fund races in
which a bonus of $4,000 is paid
the breeder Of the winning
horse and another 1880 to the
owner of the winners sire.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
2 Montgomery Schools
Get New Cage Coaches

four years Of service ball, two
with Camp LeJeune's basket
ball team.
He completed his basketball
apprenticeship with four sea-
sons Of play under Coach Dave
Carrasco at American Univer-
sity. He attended AU on an
athletic scholarship. The Eagles
won three Mason-Dixon Con-
ference titles during his four
years there. He also caught for
Coach Carrasco's AU baseball
team. -
Il never had a better hustler
than Walt" Carrasco said after
learning Of Dupee's appoint
ment. He was a fine student
OF the game and should make
an excellent coach"
Gilmore. a 1852 graduate of
the University of Maryland,
where he was on the football
squad, guided the johnson jay
wees to a 500 season last year
but doesn't expect the Spar
tans TO come close to their 1873
mark Of last year.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07

The Fred w. Hooper stable was
famous for a duck that wad-
died around the barn.
A shaggy little pony named
Peanuts was always near Exter-
minator. Cicada, the 3-year-old
filly champion now at Hialeah.
has a little Shetland pony
friend.
We've had everything
around here except an Aardvark,
and I'm not so sure about that
even." said a Hialeah man.
"One winter some guy shipped
a long nosed animal In a crate
10 trainer Bobby Merritt, the
former jockey. II looked like
an anteater. They got rid of
that thing In a hurry"
The matter finally got down
10 the famous Hialeah Fla
mingos, the graceful pink birds
that fly around the infield
lakes. What about them2
Don't bring that up." the
man bald.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07

But, there's no use having
a dissatisfied millionaire loaf
ing around running up food
and lodging bills all winter at
those Miami prices.
Would Kelso 20 to Santa
Anita Park in California in
stead2
mo. I don't think So" Mrs,
dupont replied. II haven't any
plans"
Many trainers, grooms and
others around rece horses have
a variety OF pets. There are
chickens, ducks. monkeys, cats
and fighting cocks. Usually,
there are about four dogs per
barn at Hialeah, and there are
"a barns at the, plush Miami
track. The cat count was 100,
but hard 10 estimate because
they multiply.
Stymie. once the worlds lead
ing money winner. had a
chicken pal. Errard King re-
Taxed with a goat in his stall.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07


purse ever put up for Mary
land-bred horses.
BY breeding standards,
Nickel Boy makes Garry Back
look like an equine blueblood.
Nickel Boy was foaled at
Melvin p. Blackburn's Friend
ly Farm near Ellicott City, Md.
His sire, named His Nickel. ran
in cheap claiming races until
he was nine and then was used
for a pony on Blackburn's farm
before being bred to q mare
named Carickmacross.
a.. IS as
Not. long after Nickel, Boy
was born both his sire and dam
were sold to a livestock dealer
for processing into dog food.
His Nickel went for SOS and
Carickmacross for $50.
A most sturdy campaigner.
Nickel Boy has earned $685.
662 and stands sixth on the
list Of all-time Maryland bred
winning horses.
Nickel Boy apparently never
impressed his breeder and origi-
nal owner. Although he did win
the Marlboro Nursery Stakes in
his breeders silks, Nickel Boy
was sold to the Knollwood
Stable for a mere $4,000.
The Knollwood Stable Irwin
Grinsfelder and Jack T. Sad
dler) later lost him in a claim
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
BY STEVE HERSHEY
star staff Writer L

Walt Dupee and Jim Gilmore
have BEN named to head
basketball coaching positions
at Montgomery County's
Wheaton and Walter johnson
High Schools, respectively.
Dupee, after one season as
junior varsity coach, succeeds
Ray Fox. who has transferred
to Montgomery Junior College.
Gilmore replaces Allan Swick
as Spartan coach after serving
seven seasons as the junior
varsity pilot at johnson. Swick
has given up athletics to assume
an administrative post.
The 29-year-old Dupee put
together IL successive seasons
as a player before taxing the
tayvee coaching job at Wheaton
last year. He had q 1875 record.
Dupee is a graduate OF Rich
ard Montgomery High School,
where he played three years Of
basketball. football and base
ball, graduating in 1862. He
Joined the Marines and played
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
New YorkS
.St,127 Million
BET Record

ALBANY, N. y, Dec. Z (AP).
The total amount bet aS
horse racing tracks In New York
State reached a record $1,127,-
023,764 this year, the State tax
department reports.
Total attendance Of 14.2 mil
lion persons at the IL tracks
and State revenues Of SOS mil
lion.
New York tracks are Aque-
duct, Belmont, Saratoga and
Canandaigua, all flat tracks,
and Roosevelt. Y0nkers, Sara
toga, Monticello, Batavia, YER
mon, Buffalo Raceway and
Goshen. all harness tracks.
The States share Of the bet
ting included SOL, 679,93o in
pari-mutuel taxes. Most Of the
$l05-million balance came from
taxes on admissions.
Overall State revenues were
$6.5 million above the 1861 fig
lure. Tst
The record handle Of S1,l2T,-
023, 764 in 1,107 racing days this
year compared with 81. O61, O4l,-
53l in 924 days last year.
At the flat tracks this year,
q total Of $596,9l4,52O was bet
lin 296 racing days, compared
with $544,251 ,460 in 221 days
last year. -
The States share was SOL
636.605, compared with $780,
17S,021 at three tracks last
Iyear.
The total handle at harness
tracks In 721 days Of racing
this year was $3.50, 109, 244, COM
pared with $516,790,071 in 70S
days last year. The State re-
ceived $40,O43,334 from the
harness tracks this year and
$50, 149,708 last year.
The record attendance this
year was achieved through
crowds totaling 7,523,273 at
harness tracks and 6,768,144 at
the flat tracks. Last year the
attendance figures were 7,491,-
$50 and 6,1l9,697.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07

Joy for all at Garden State Park
when Kelso won the Governors
Plate. picked UP $35,l00, and
became racing's fifth Million
aire with earnings Of i.0il $40.
Kelso. who has Just been
named horse Of the year for
the third straight season, is
down on his owners farm at
Chesapeake City, Nd, taking IL
easy with his friends while his
winter racing plans are being
determined. II had been
planned 10 send the 5-year-
old champion 10 Hialeah for
some of the rich races. includ-
ing the 100000 Widener Feb
ruary %. But. Mrs. DUPONT
points out, Kelso fretS when his
two canine companions aren't
with the racing stable. .
He likes them. and doesn't
seem like himself when they
aren't around" she said. Mickey
has been travelling with her
stable since he was q pup.t
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
Speedy Scot Tops
Juvenile Trotters

COLUMBUS, Ohio, Dec. 7
(AP).-speedy Scot and Over
trick have been named the top
2-year-old harness horses in
the Nation for 1862 in a poll
of sportswriters announced to-
day.
The United States Trotting
Association, which conducted
the balloting. said As of the 101
newsmen named Speedy Scot,
owned by Castleton Farm of
Lexington. KY, the top juvenile
trotter and selected Overtrack,
owned by Mrs. Leonard J. Buck
of Far Hills. N. j., as the best
PAGER.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
STEADIEST CIV BACK
Poshe, Giants Confer;
Defensive Role Likely

considering entering medical
school.
His application to @. WIS
medical school will be consid-
cred by university officials
after spring football practice.
At the moment, pro football is
believed to be no better than
third choice in Drummond's
plans.
Pashe. a 6-foot, 175-poundey
from Teaneck. N. j.. was
Drummond's replacement on
defense during the 1861 season,
and was the regular right half
back this fall.
Second 10 DrummOnd
Playing both on offense and
defense this year, Pashe wound
up second TO Drummond in
rushing and pass receiving with
237 yards on 81 carries and
ll8 on 10 catches. He also
was runnerup 10 Dick In kick
off returns. but led the club in
average distance with 22.8
yards, and led In punt returns
with IL for 100 yards.
Pashe drew praise from Coach
Jim Camp as the Colonials'
steadist. most versatile back
throughout the 81 Colonial
season.
HIS best game on offense
was. the 1912 victory over
Brigham Young, following OPEN
ing defeats by Virginia Military
and Virginia Tech. Pashe
scored the first touchdown on
a l4-yard run and helped set
up the second with another IA
yard dash, and he totaled SO
yards in tries.-SLAY.
Evening star. [volume] (Washington, D.C.) 1854-1972, 1962-12-07
ToIus Brothers
Draw at Capitol

The Tolas brothers. John and
Chris, and Johnny Barend and
the Magnificent Maurice wres-
tied to a 30-minute draw in
last nights feature wrestling
match at Capitol Arena.
In other bouts Killer Kowal-
ski and Killer Austin whipped
Arnold Skoaland and Bob
Boyer. Gordo Chihuahua de-
feated Gene Kelly. Pedro Mo-
rales beat Tony Altimore. Pat
Kennedy defeated Guy Taylor
and jolly Charlie won over Lou
Albano.