Seward daily gateway., 1925-04-24
CURE FOR SLEEPING SICKNESS, THE
 SCOURGE OF AFRICA, IS BELIEVED TO
 HAVE BEEN DISCOVERED BY CHEMISTS

NEW 1OUh, ApF. Io.--h6lleI ana even cure for sleeping sickness, the blight of Africa, has been found, it is believed, in the new drug Tryparsa mide, recently projected, created and tested by four staff physicians of the Rockefeller Institute here.
 Dr. Wade H. Brown and his asso- ciate, Dr.. Louise Pearce, who have tested the drug for it's effects on ami mals and men, and Dr. Walter A. Ja- cobs and his associate, Dr. Michael Teidleberger, who attended to the chemical phases of the work, announc- ed today that sufficient experiments have been made with tryparsamide to justify, apparently, their hope that it is comparatively sure cure for sleep ing sickness.
 Lately, the disease has become more common in many regions known to be affected and is spreading to re- glons previously supposed to be free. Inspired by stories of the ravages of the dread illness of Africa, members of the institute began Investigating possible cures several years ago.
 Tryparsamide was evolved. First tests were made on mice and rats and guinea pigs, all with rare success And in May, (1920,) Dr. Pearce set forth, adequately equipped, for the Belgian Congo to work with expert Belgian physicians to test the drug on man and to help the stricken negroes in the land of sleeping sickness.
 Tests Successful.
 Experiments have been made by numerous physicians" Dr. Pearce said, ito justify our hopes for the drug. The results of my first clin- ical investigation, based on the treat ment of seventy-seven patients in Leo poldville, Belgian Congo, demonstrat- ed that tryparsamide caused a prompt disappearance of the germ called try anosomes from the blood and lymph glands a rapid improvement of the abnormal cerebro-spinal fluids of ad- vanced patients, which in the major lty of cases, amounted to a restora- tion to normal and a marked improve. ment in both physical and mental states.
 "Of the thirty-five very advanced cases, only three died. Thirty-two pa tients were at last reports, alive and we'll, with negative blood and lymph glands.
 Tn New York City, two Americans in the advanced stages of sleepingg sickness, have been successfully treat ed with tryparsamide. One patient whose condition was extremely grave was given tryparsamide intervenously and by the end of three courses of ten doses, both her physical and mental condition appeared normal. Since this time, she has resumed her household and social duties which have been only interrupted by the additional treatment administered. The other re- acted even more quickly, and with equal success"
 Caused by Fly.
 Sleeping sickness is an unusually dread disease, caused usually by the bite of the tsetse fly. It's victims do not at first seem very i'll, according to Dr. T. Mitchell Prudden, who has made a special study of it. They may have little fever and the lymphatic glands about neck and elsewhere in the body become swollen. They often go about their business for months. even years
 But sooner or later, unless they get suitable medical treatment. they be- come dull and apathetic, sometimes have headaches, tremers, low fever: the heart labors and after a while they emaciate, become feeble, drowsy. lethargic and lapse into coma and so die, forlorn. The invading trypan- somes which appear in the blood, are the diseases incitants. They damage the blood, incite a series of inflama- tory reactions ill the body and when at length they invade the brain, bring on the sleeping sickness and lethargy which forecast death.