Evening public ledger. [volume] (Philadelphia [Pa.]) 1914-1942, 1917-01-30
Exact Serum Dose
Found for Meningitis



the immune serum, I,il'reul ttSIS We're
L'ue, 20, .''g -. ,,, '!'''''- nc ID"
oi"t".S 0S ,'''',l,,'' '.. "'I G'u't"
Sst ,L ,,,,aIs ,,,,,,.I,, t,Y, ~ ~
- -. ,i,,r-,,l,,, ,rs ~. liz -, ~
St St ~ ~ @ , - W
aftor hoiry fnier,.d Iorra dose. or ,hs
haotoiai c7,It,r, l,iIIad tEn ,rtr,,aIs. b,. Mo,
S,,os,- ir,t1yic,tfrr ,,.i,rnut tr,. i,f,,tt,,,
rlora,,sa of this tha artf-inFartfva noyvar nf
~, 'sSr,,r, ,,,,II NOT bn Ia,ar,,,f,,,d
Tba Robinson discovery grew nut of the
In,.antio,, 90 g, means of rnarinr,atirrr tba
a actario in trair transfer tn tba laboratory.
81 nir,ai For his nurnose a scrias' of about
fsn white mice is used The mice 6rst AFRO
created win anuaI ,hdor1ip,I ipiscti,,,s ~
immune serum, hostile to the several strains
of meningococcL About an hour later
hxed amount OF bacteria is suspended in one
cubic centimeter of guinen-pig serum Half
of this is injected INTO the abdomen of the
first mouse. To the other half Is added q
half cubic centmeter OF fresh gutnea-pg
serum, and half of this mixture is injected
into the second mouse In this manner each
succeeding mouse receives half as much Of
the culture as the preceding animal The
Euinea-p.E serum acts ass q medium to
effect the transfer Of the bacteria
The first three nice which receive the
greatest amount of bacteria usually die of
.ba infection whra tb.i,. .i,,,f. ~ I..,tb
after bacterial injection varies fror, fou,, ~
eight hours on an average tha daa+b r,te
rannafns constant Artar forr,--.f,,5+ r,,,,,
no more deaths occur. the remaining mice
- ,tIsi '''l ,'.'''''.R '''~'
iri5is go, ,,tfs, ""'
,,raTrart ro, sar,irr, i,+,,,f -,
.ba Nyr1rrrI I,,,,.,i,rs. 80. ,.''.7 'T
do,,ht urb ~ No.. lr,rr,, rf 'S,..''t |,'
ou"t ~. r'l @''o! N''''"'l " P4gS'S'"H Ut
lne iIJeIlII" OF immune serum INTO 80
sP''.aL N.''i'' 40. '' cur OF i'''iiEIlls.. Al
~ e. ~ W 49, ms 5 P'uS9 oI '"JeGt'oHS
a 'e" - "'"'g1' u"''"'iIt 7NC1lasiuI re-
80 an" s.e HsNe''p'h'Lt "i ".\H' on the
par Ul PnES'1''hS 'H i'U'l"HeIpha ana
otlie' .o'P @ as ''e a'""'"I Iu'1ht"h OF the
amount OF serum 90 ne used M treatment rs
EesaruSu as an important step M the war
on epidem'cs.
NEED OF STANDARD
The need Tor Standardization WAS pointed
out by DE-. = ; Woody chief resident
physician or the Philadelphia Hospital for
Sohtaslous Diseases, and Or Henry H.
1oaH SnleI IesldeHl pAys.cian of the
Itil.aue5Pi .I Tenelal Hospital where
ms ms u we serum treatment TOR men.n-
s-t.S .S,,n ~ ~ e.sS nag hvrH administered
s.r,,yp .'',l'u Vi l"Jt'l.Hi anu-m 'ning tis
$50 uH " 80 - ND'N.h+ "lLdl 10 the
eotu.'e 49,, VI 'm7 hI'" ansl'hctea from the
SIN t'II a. ss a1'u i'+'In' woody. This
,'' LEI ~. Iup.S cent t'LlettF5' but II
bsd av,afT., -, ',l' "l IHe case. We
rs,taG d,,-t,,,l 't+t'' III .ne cases thAt We
the infantile PARALYSIS enits,.ir p,,, 10y
ae,,t,aiti- f 'a'' tp'ueI,le. But
reason We ba',e no - 10 anu Tor tAat
~ recoyer,, ., @''S' wa '"e percentage
The comparatf,.al,, email r,,,,-.t..
Of meningitis trsat.5 at i'-'''-s. "I cases
HospitaI nrevspfs The ,,,,,,ft ''.l'us tp'''a
thoritatiye statisrics 81 XXX 1'l1n %, "u-
eordinP 10 Doctor Nan ''7'P'''' "e-
I'VE have perbaDe tbirt,. ,..-t..
cases a year" he said a,rIiI 51 toIt
small number I'm itself vouId NOT ~
Of conclusive nature we have no. ,,,,,,
cases 10 observe to Obtain a deanfte ,,s,
Some of the cases in the early stag. rss5,It