Evening journal., 1916-08-04
JAPANESE REPORT
TUBERCULOSIS CURE
DiScoverer of Cyanocupral,
Gives Results Of 60 Cases,
Claiming Is Successes
USED DINLEPROSY CASES
WITH MUCH BENEFIT

eum the medical world was scept-
ical II has been deluded too many
times by announcements Of "cures'
for tuberculosis. which experience
proved 10 be useless But extended
treatment OF several hundred cases
IN several hospitals in Japan by DR.
Koga Or Morisuke Otani. Prof III
tasato. Or r. Takano and others.
proves % 20 he SO successful that tho
Journal of Experimental Medicine. Of
which Dr. simon Flexnor is editor
n~d Tho Rockefeller Institute for
Medical Research the publisher de-
,oies ite ent'ro August number 20
repori0 upon e.
Chief among the items is a report
hv Dr Koga on sixtv-thrce typical
cases hat have hccn treated with
c.anocurrol. as the new medicine has
fcer called This 's followed by an
nrfic'o hv Norieulle Otaui of the Isl.
tefafc in-'tu'o for Infectious Dis
eosce. on The clinical treatment -
fuhcrculor'e potonts Finally there
g. rorclt hy Dr Y Takapo of six 4
cosc or leprosy treated with cyono-
currol In The l-hai-yen fienrosorium, /
Toxic. Til of which show such mark /
cd Improvement that n looks as WI
I've discovery might prove p cure for /
lcrrosy ar well os for tuberculosis
Tnlp- Directly Into Veins.
Briefly cyanoCnpr0l rs nm aqueous /
SOLUTION cf potassium cyanide and
copper diluted IN 1000 times IT'S vol |
ume OF Distilled water n e. highly !
irrtltiug 10 tho tissues and must be
Injected exclusively into a vcn. Doses
are given AZ intervals Of two weeks,
varying IN uuantity accordng t0 the
form and stage Of tho disease and
Tho nge cf the patient. After the in-
icciinns Tho patient must have ahso-
lutte rest for three days after The
nrst. seven days after the second and
fourteen days after the third inlec-
ten
DR. Koga's report shows that OF
nineteen cnses Of non-active tuber-
culoals In the first stage thirteen
were cured. two improved and three
were still under treatment aud IN one
the treatment was suspended OF
siS in the second stage. three were
cured and three improved. or four in
the third stage one was cured and
three improved. In cases Of active
tuberculosis, OF seven In the first
stcgc four were cured. two improved
ard ono was still under treatment or
eleven I'm the second stage three were
cured. FIVE improved. two were still
under treatment and in one the treat
mcnt was suspended OF eight in the
third stage. one was cured, three i'm
proved three died and two were still
Under treatment or eight cases Of
surgical tuberculosis one was cured.
four improved. one was st'll under
treatment and in two the treatment
was suspended The total for the
siVty-three cases is. twenty-five
cures twenty-five improved, three
died nine under treatment. four sus-
pended
How Scientist Defines Cures.
The term "cured" Is applied by Or.
Koga 10 cases that gained in body
weight. showed temperatures below
81 degrees centigrade. no. or nearly
no physical signs. the sativa free
from hac'lli and the patients attend
Ing to their regular work. Improved
means the same except that bacilll
are found occasionally in the saliva
and other symptoms are still present
Dr. Koga sums up his results hy
saying
"A general review Of the cases viii
7 think, indicate that the preparation
greatly improved or apparently cures
pulmonary and surgical tuberculos's
IN the FIRST and second stages ant
that IL seems also 10 produce hene
fetal effects upon the disease in the
third stage Tho duration of thes,
beneficial effects is still 10 ne estab
lished by more numerous trials anf
many years Of observation.
Dr Otanfs report is dated ter
months later than DR.. Koga's. Hl
sums up IN part as follows:
"Cyanocuprol is markedly effec
tive in tuberculosis. and we believe
that IL win play an important part ir
clinical medicine. II may be uses
more generally than tuberculin.
"rhe amount Of the 6ose is CLOSELY
related to the reaction and the fna
results II should be determined fol
each patient after a careful eXamina
lion Of his symptoms Tho maximum
dose OF SO cubic centimetres SHOULD
In no case be exceeded Tho short
est interval between injections should
be two weeks If the drug Is giver
after a shorter interval no improve.
mcnt is observed and the effects are
sometimes dangerous.
During the period OF the treat.
ment irritants 70 the lesion. such as
potassium, iodide or tuherculin should
be avoided; apricot guauiacol and IN
derivatives and idol are contraindi
Gated
Little Hope In Final Stages.
There are cases in which evan
ocuprol does no good In the fns
stages Of consumption it may be give
without danger but with little hor
OF improvement Even in cases
pulmonary hemorrhage IL is ben,
fetal. and il may safely be used whs
fhe tuberculosis is complicated wi
chronic diseases Of the heart and XII
ney
Each injection Is followed gener;
lv. BY a fleeting local inflammatiC
often by an increase tn the cough a
sputum. but with perfect rest the
symptoms passes away in two or thr
days. AS absolute rest is necessal
the coughing must be stopped. a
DIT Otani does IL by administer
codeine hydrochloride. He helps 1
expectorstion by spraying the no
with a solution Of the gramme
=