davidaulloa/AmericanStories huggingface dataset:
The Topeka state journal. [volume] (Topeka, Kansas) 1892-1980, 1914-05-14
It Will Pay You

to buy a S. Grocery and Meat
order, at the C. o. D. Store. Try
it once. Free Delivery.
Peanut Jumbles, a special, Ger
man style cookie, a 15c re-
taller, priced at, h.. 90
Halibut Steak, per Id. 49,. .15t
California Hams, (smoked
shoulders), h.. $685.. law
Hams, good quality, skinned,
half or whole ham, h.. .17Nf
Mackerel, 1Oc size, 2 for. :. :. 15t
Pie Plant, fancy homegrown,
Crisco, small can, 22t; medium,
az; large $40
Flour, a good bread flour,
48 Id. sack 81 OF
Soap, a good white laundry
soap, 10 bars ...........31t
Sour Pickles, gal. ......... 500
Regal Flour, a fancy Kansas
Wheat Flour, 48 lb.sack $1.15
Other Items
Baking Chocolate. 20 cake. ~. 16c
Pancake Flour, 10c packages.
two FOR .1... 80
Ivory Soap. 10c bars, 2 for. ..... 15c
Baking Powder. Is or : can. .isc
The Topeka state journal. [volume] (Topeka, Kansas) 1892-1980, 1914-05-14
TOO LATE TO CLASSIFY.

WILL SELL stock Of clothing and fix
lures in bulk or In job lots at "a Kan
sas ave. H. F. Taylor.
The Topeka state journal. [volume] (Topeka, Kansas) 1892-1980, 1914-05-14
LOST AND FOUND.


LOST-Watch and chain on Western ave,
between End and 3rd. Reward. State
Journal Business Office.
LOST-On Sth and Kansas ave, pocket
book containing money. West Motor
Car Co. Reward.
LOST-A tan pocketbook Containing forty
dollars. Finder please return to 81 East
7th st. and receive reward.
LOST-Silk yellow center piece between
End and Branner and 9Th and Madison.
Reward 20s Branner.
NEAR 9TH and Tyler. or on South To-
peka car. F. A. A. pin. Phone 2S2S Blue.
The Topeka state journal. [volume] (Topeka, Kansas) 1892-1980, 1914-05-14
WANTED-SlfUATlONs.

WANTED-SlfCATl
<-N<>cc<><>>>~>~-~>>>>~>>
SETTLED steady man. - years Of age,
wants job Of some kind in Topeka; have
followed carpenter trade. farming, saw
milling and grocery business. Address
b. b., Journal.
CAN YOU USE a trained mind in your
business? Have had 20 years' experience
In newspaper and printing work; wish to
change. Address Jim, State Journal.
WANTED-By young man student, place
to work for board. Phone 6o6-w.
The Topeka state journal. [volume] (Topeka, Kansas) 1892-1980, 1914-05-14

Natures most economical
sea food. Tall cans Csc
Rrade) per can. .13C
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20

Why not catch Villa and Transport
him to Europe where his thirst for
blood can be satisfied?
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
ONE MORE UNDER
CHARGES FIRST
DEGREE MURDER
SARAH MITCHELL, coLoRED, WHO
is HELD FOR DEATH OF HUS-
BAND, INDICTED AND is RE-
MANDED FOR TRIAL FOR LIFE.

Jailer O'Neal was given charge Of
urday night, charged with murder in
the first degree, this being Sarah
Mitchell. colored, charged with the
murder of her husband, Frank Mitch
ell, in the lower eastern part of the
city. several months ago. This is the
fourth person in the county jail al
ready under Indictment and who early
next month will face trial for their
lives in the circuit court. All were ar
raigned yesterday.
Sarah Mitchell was the woman who,
it is alleged, while in an intoxicated
suits upon her husband who is said to
have unbraided her for going out against
his wishes. When police officers reach
ed the house where Mitchell was killed,
they found the latter in a pool of his
own life blood, and at once charged his
wife with the offense. She afterward.
under oath. it is alleged. state that
she had used the knife on her hus-
band. but did so in defense of her own
life, she believed. She was later dis
charged from custody on preliminary
hearing. Her appearance bond was
yesterday placed at $1,000. but she was
locked up pending the furnishing of
held the first week in November, and
she will be the second woman to face
a jury in a fight possibly for her life.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
TWO NERVOUS
WOMEN
Made Well By Lydia E. Pink
hams Vegetable Compound.

Philadelphia, Pa. Sc had a severe
case of nervous prostration, with palpi-
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20

Vegetable Compound so I threw away
the medicines the doctor left me and be-
gan taking the Compound. Before
had taken half bottle was able to sit
up and in short time was able to do
all my work. Your medicine has proved
itself able to do all you say it will and I
have recommended it in every household
/ have visited. Mrs. MARY JOHNSTON.
30 Siegel Street, Philadelphia, Pa.
Another Bad Case.
Ephrata, Pa" About a year ago
was down with nervous prostration.
was pale and weak and would have hys-
teric spells, sick headaches and n bad
pain under my shoulder blade. / was
under the care of different doctors but
did not improve. was so weak could
hardly stand long enough to do my dishes.
Lydia E. Pinkham's Vegetable Com
pound has made me well and happy and
I have begun to gain in weight and my
face looks healthy now. Mrs. j. W.
HoRNBERGER, r. No. 8, Ephrata, Pa.
If yOu want special advice write to
Lydia e. Pinkham Medicine Co. (conf.
dentiaD Lynn, Mass. Your letter win
be opened, read and answered by q
woman and held in strict cn-'" f-.,or.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
Necessity for Reducing
the Police Force.

The st. Petersburg Times contains
the following very pertinent comment:
Pens@cola's mayor thinks that city
has a great deal too many policemen,
and The Journal thinks so. too, and the
News wants to know il there are too
many why it has not been noticed De
fore? Perhaps it has. In most towns
lots Of things are noticed for long
time before anybody does anything
about them
The point Is very well taken. Also
It might be said with equal truth that
very frequently we are compelled, by
force OF circumstances to do things
that, even though they had been
thought OF before, were never neces-
saRy before
There ig not a business man in Pen
sacola who, in view of business condi-
lions during the past year and oar
tacuIaxfy the past three months, has
not been compelled to reduce his ex-
penses. There is hardly a family In
Pensacola that has not been compelled
to retrench.
A city should practice, when neces-
sary, the Same rules Of economy that
an individual practices. If the city's
income does not meet its expenses,
then those expenses should be trimmed
down to meet the income.
The city OF Pensacola is forced by
decreased revenues to reduce its ex-
pense of operation. Nobody wants to
see such a reduction, but necessity
compels many things that nobody
wants to see. The most practicable
way to decrease expenses Is to cut off
that part of the expense which is least
necessary. The police force contains
more men than are necessary and con-
sequently some Of them should be laid
off as the most logical way to decrease
expenses.
That is really all there Is to the sub
Ject Mayor Greenhut, we believe, has
the approval of the tax-paying people
of Pensacola in his effort to put this
purely business proposition into eff
feet.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
The Responsibility for
the European War.

In it's "Vox Popult" department to-
day, The Journal publishes a letter
from a German reader who takes ex-
ception to an editorial which appeared
in these columns a few days ago.
We are glad to publish the letter
from our German friend, but we much
regret that instead of combining him
self to the point at issue he finds it
necessary to go out Of his way to
charge The Journal with being
badly misinformed," with having an
anti German feeling" with being
with creating hatred" and with a
lack of character" None of these
things, even If true, can possibly have
any bearing on the causes or pur-
pose Of the European war.
1t is true that public sentiment in
America and we believe. throughout
the world holds the German Kaiser
and his government responsible for me
present war It may be that public
sentiment is mistaken. 1t sometimes Is
mistaken 1t may be that France or
England or Russia or even poor little
Belgium struck the first blow. If they
did, the facts have been suppressed.
It may be that Belgium invaded Ger
many, that Russia crossed the border
and swooped down on the Kaiser be-
fore the latter declared war. that Eng
land carried hostilities into the Kiel
canal, and that France is even now
being held back on German territory
from a march on the capital at Ber-
lin. If all this be true, then Germany
was fighting on her own ground
against outside invaders and her "eXis-
tence' may have been at stake.
But when our German friends crit
Iclse the American newspapers and
American public sentiment, they
should remember that our opinions are
formed by the facts as they are
stated to us No statement OF fact,
even from Germany, as to the causes
OF the war has thus far been sufr1-
ciently explicit or convincing to per-
suade American public opinion that
the Kaiser and his military advisers
are not responsible for the conflict.
No fact has thus far been presented
which goes to show that the Kaiser
did not strike the first blow.
The fact that now. after the decla-
ration of war, the German people are
supporting the Kalser's war does not
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
CASES OF THE OHIO MILITIA
SUBMITTED TO SUPREME COURT

Washington, Oct. ia motion fer
an early hearing of the case of Lieut..
Col. Daniel Stearns against Brig. Gen.
George H. Wood, both of the Ohio ma
tional guard involving the power of
the president to send the militia out
of the territory of the United States
without first mastering it in as vol
unteer force, was today submitted TO
the supreme court. The point was
at issue in militia circles few months
ago, when the guard was preparing
for service in Mexico
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
TWO CALLS FOR
TIE FIRE DEPT.
CORNER GROCERY AND FRUIT
STAND, AND A FRAME BUILDING
WERE CONSIDERABLY DAM
AGED BY THE FLAMES.

Two calls were turned i'll for the fire
department yesterday, the first heing
shortly after l O'Clock in the mornin@
when the store of Louis Vasso, at the
corner of Jackson and Alcaniz streets
was discovered in a blaze. The place
was badly DANA ged, but the depart
ment did excellent work in confinins
the fire to the one building.
At 1:17 O'Clock yesterday afternoon
fire was discovered in the roof of the
frame dwelling at 115 North Barcelona
street, and a carl from box 81 summon
ed the trucks. The roof of the place was
BADLY DANA ged.
Since the weather is getting cold
now the advice Of the fire chief is that
all persons make an examination of
flues before the CRATES in either resi-
dence, office or business house are
made use Of A little caution in this
respect will keep damage from the
flames down to a minimum, it Is as
serted.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20

court Of appeals, and will be ou' o, F..
city for a1out a week. Judge Srop7g
will sit in place Of the newly b,o.n'
cd iurist, Judge Walker, who 7s- nm.
recently named to fin tho Hrsr.
caused by the death Of the la0c TiE
Shelby.
Judge Sheppard did not expect No. .
out Of the city for some tuo tui r
request which ne received fr.'rr.
came In tho nature Of a surprise N
mad only res urned last week from .
extended term in New York stat
where he had been assigned 10 rr
A conGested docket il Is believed r
Judge Walker may have been disaue
fled In some manner from sirtru-
cases which will he presented ~ .
court Of appeals, and The local fc1~
jurist was asked 10 aCt IN his st.|
Judge Sheppard and Sccretary y
Hoffman expect TO he out of tho 81
about a week, and not moro than i
days.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20

t2tlon or the heart,
constipation, head
aches, dizzine s S,
noise in my e ars,
timid, nervous, rest
less fe e lin gs and
sleeplessness.
" l read in the pa
per where q young
W ON an had been
cured of the same
troubles by taking
Lydia e. Pinkham'S
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20

The Want Ad Wax
page is one Of the great tca
lures & This paper. Read
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
DIR. CHAS. r. MITCHELL
0STEOPATAIC PHYSICIAN.
Masonic Temple. Hours 9-12 and 2.5.
Phone 1880.

Masonic Temple. Hours 9-12 and as.
Phone 1880
Eleven years experience In the treat
nent OF all suk-acute and chronic dis
eases. such as Asthma. Backache. Bill
iousness. Bronchitis. Constipation.
Cramps. Coughs. Odds. Dyspepsia. Eye
and Ear Disorders. Diseases of Women.
headache, Insomnia, Kidney and Liver
troubles, Lumbago, Nervousness. Neu-
ralgia. Neuritis Paralysis. piles. Rheu-
matism, Stomach Diseases. Sciatica,
Spinal Curvature. Stin Neck. Stin Joints.
etc.
The Pensacola journal. (Pensacola, Fla.) 1898-1985, 1914-10-20
FEDERAL JUDGE
W. B. SHEPPARD
TOMONTGOMERY
HON. WILLIAM q. SHEPPARD AND
SECRETARY HOFFMAN LEFT
LAST NIGHT FOR THE ALABAMA
CAPITAL FOR A WEEK..

Federal Judge w. 3. Sheppard and
secretary, Earl Hoffman, left last night
for Montgomery where Judge Sheppard
will sit on a number Of cases in the
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15

l.. Starcher on charges of selling
whiskey in violation of the Yost pro.
hibtion law.
Twelve pints of whiskey were
found by the police in Caughlin's
room. while in, Mrs. Reeds room was
found one pint and twelve empty
pint bottles.
The squad of police was under
Lieutenant Nicholas NJ. White and
was made up of Sergeant Post and
officers Howe and Davisson. The
place had long been, under suspicion
by the police.
The warrants were sworn out by a
member OF the city police depart.
rnent.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Brotherhood Sociali'

The brotherhood will hold its De-
cember Social in the Methodist Epis-
copal church Thursday night. It VIII
have Christmas tree then and Santa
Claus has promised to be there to
lend hand in giving the soberSmind-
ed ones some fun. The men are in
yited by cards and they are expected
to take any present they wish to give
to some gentlemen. The whole thing
Ia to be farce in one act. 4
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Christmas Bazaar.

Fancy and practical Christmas ar
ticles will be on sale Wednesday and
Thursday afternoons and evenings at
q Christmas bazaar by the women OF
the Church Of the Immaculate Con-
ception in the st. Mary's high school
auditorium. Coffee. cakes and sand
witches will also be on sale. The
proceeds will go toward the building
fund Of st. Mary,s high school.
Everyone is cordially invited to at
tend. I.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Well Written Papers Read.

Tuesday afternoon at a very inter-
esting meeting Of the Tuesday Liter
airy Club held in the home Of Mrs.
John j. Davis. Argentina was the
country studied ana well written pa
pers were read by Miss Mary McCiel-
land on Natural Resources and Ag-
riculture." Railway Siylst.e ms
Mines and Other Industries, by Mrs.
Harry T. Wilson. The federation
topic, "The Problem of Unemploy-
ment," was presented by Mrs. John
Ruhl followed by u general discus.
sion.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15

The, Rev. George W. woofter. of'
Bridgeport. visited the city Tuesday.
Edward N. Koehler, former resident
Of the city. is here from indianapolis,
where he will locate permanently.
John Dunkin was a business visitor
here Tuesday from Bridgeport.
c. G. Flanagan was here Tuesday
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
POLICE RAID
Glen Elk Flats and Arrest Man
and Woman on Charge of
Selling Whiskey..

As . result of raid Of city police
on the Broadwater fats. Clark
street. Glen Elk, Monday night, Har-
~ Caughlin, tool dresser, and Mrs.
Andy Reed. who has charge OF the
fats, are In the county Jail awaiting
hearings before Magistrate William
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
R. M. Moore. Of parkersburg, is a

visitor in the city.
Misses Susie Carr and Gertrude
Smith, Of Gassaway, are guests oil
Miss Cynthia Carr, Of this city.
w. Il. McGlumphy is here from
Moundsville on brief business visit.
G. i. n. Smith, Of Wheeling, is al
guest at the Hotel Gore.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Fancy WORK Diversion.

AT the close Of the business session
OF the meeting Of the Monongahela
Camp Fire Girls held in the home of
Miss Anna Garrett Monday afternoon.
fancy work for Christmas was the
pleasant diversion. Later refresh
ments were served.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Marriage Announced.

Mr.. and Mrs. Walter H. Gallien
announce the marriage of their
daughter. Augusta Gertrude, to Mr..
Fred Aaron Ritley. Of Fairmont, at
Fairmont. Saturday. December 10.
Mr.. and Mrs. Ritley will reside at
Fairmont.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Mothers, (,lub to Meat.

The stealey Mothers Club will
meet at o'clock tomorrow afternoon
In the home Of Mrs. U. E. Waters at
Stealey Heights. The subject will
be Conservation. All members
are urged to attend.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Philips shet and Tin Plate com,nanv

fnliiips Shet and Tin Plate Company
Saturday night. DR.. S. NJ. Mason.
coroner. decided that the man had
been killed by the street car and that
as no signs Of foul play could be
found, no inquest was be held.
Conditions surrounding the acci-
dent tend to show that Korycki had
not been dead but few minutes
when the baby was picked up by the
street car men and II he had been
killed and placed on teh track the
body would have been in a different
condition. It has also developed
that Korycki had been respondent
Tor several days and he may have
tsken this means Of ending his life.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
C.ircIe Meets

At $3.50 o'clock Tuesday afternoon
there was a very interesting meeting
Of the members OF the Queen Esther
Missionary Circle held In the parlors
OF the First Methodist Episcopal
church.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
PdrsOns-S Oltders
Store Closes $50 To-Day
Store That Has Served You Best

Is Serving !
D A D /!
It's all very well to say
how good he has been about it
all but what are you going
to give him?
Be sure of one thing he wants
something a man wants-and we
never yet. have met man who real
ly in. his secret soul cared duca-
toon for anything hand painted at
home or stitched or Tossed up with
edges on it. Ofcourse, he appreci-
ated it; thought it very considerate
and kind, but just the same HE
DIDN'T WANT IT! He was kind
OF looking for something worth
while and WORTH THE Money!
Now we know WHAT MEN
REALLY WANT and right here
we have a large collection of the
things men luant'
Bath Robes of Terry Cloth; wond-
erful patterns; winter weight, with Slip
pers to match; SIS to $3.50.
Blanket Robes So to $3.50.
Hdndkerchiets, such as one might
buy on Fifth avenue or State street
just those fine linens in varied width
hens. So dozen. boxed. Hand en-
broidered initials in high colors on fine
Irish linen, $500 for box of six. Other
initials in block designs, 9Oc and $3.50
a half dozen.
Plain hens, SC to soc each.
Umbrellas, 81 to $40.
Hall Hose, in fine Isle thread at
25c pair on up to S1.5O for finest silk;
colors and black; specially fine are the
ssilk socks at SOC pair.
Suspenders, 25c and SOC.
Cuff Links, Csc, SOC and $1.OO.
scarf pins, 25c, SOC and $1.O0; scarf
holders, 25c and SOC; vest chains, SOC
and 81.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
business Meeting

A business meeting OF the Aid So
ciety of the First Presbyterian church
was held Tuesday afternoon in the
parlor OF the church.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
To BE Hostess.

This evening Miss Bertha Bland
Will be hostess Of the ceremonial SEES
sion Of the Pinnickinick Camp Fire
Girls in her home on West Main
street. All members are asked to-
attend. W. A
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
SOCIAL and Personal
To Entertain C1nb.

Mrs. Edward G. Smith Will enter
tain the Five Table Card Club from
2 to 5 o'clock Thursday afternoon in
her home at Broad Oaks.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
Personal

Miss Eleanor H. Blackford Of
Parkersburg. who visited her grand
parents. Colonel and Mrs. Henry Hay
mond, returned home last evening.
The daily telegram. [volume] (Clarksburg, W. Va.) 1901-1926, 1914-12-15
kORYCKI KILLED
By Street Car is Decision Of
Coroner Mason and No In
quest viii Be Held.

After making thorough .investi-
CATION Of the death Of wilton
Korycli, who was run over and killed
by street car near the plant q the
Albuquerque morning journal. [volume] (Albuquerque, N.M.) 1903-1926, 1914-09-27
CATHEDRAL At
. RHEIMS SMASHED
BADLY BY SHOT
Unless Historic Building Is
Repaired Soon II win Be
Ruined by Rains and FroSts,
Says Visitor,

london. ScIt. - t.u5 A. M "A
Reuter- dispatch from Paris says Thic-
bault sisson. art critic OF The Temps.
has visited the cathedral al Rheims
and gives the following description OF
the structure as Il now stands:
To Judge OF the damage Vt was
necessary o~see the tower There |
sun bells completely melted. The roof.
which was made OF lead plates. had
entirely disappeared: the magnificent
campanile, made OF wood and lead.
erected al the crossing Of the tran
septs and apse had vanished. The
vaults still are standing and the nave
was not touched by fire"
The writer thinks. however. that
the autumn rains and frost will play
havoc with the stones and that meas
ures must he taken Immediately Ia
strcnethen the walls He concludes
by quoting the words OF the German
emperor's son to the Rheims munich
pality few days before the lombard
ment
The best proof Of my desire not e
touch the building IL that | am anxious
TO put the wounded inside
Albuquerque morning journal. [volume] (Albuquerque, N.M.) 1903-1926, 1914-09-27
NEW CASUALTY LIST
OF BRITISH OFFICERS

!. London. sept. % C5:55 y. MA
casualty list received from the British
general headquarters IN the field UNI
der date Of September 22. gives the
names Of ihirty-flve officers Killed
fifty-four others wounded and thir-
teen missing
The casualties In officers among the
various regiments included: the
Sherwood forcsters. four Officers kill
ed and seven wounded: the connaught
rangers. four killed; the South Lam
cashire, three killed and three wound
ed: the West yorkshires, three killed,
-four wounded, including Col. F. W.
Towsey. AMI eight missing; the Wor-
cestershire regiment. three Killed. five
wounded and one missing; the Dur
ham light infantry five killed and SIX
wounded. and the East forkshlres'
five wounded. including Co. X. L. Ben
son and three missing.
Albuquerque morning journal. [volume] (Albuquerque, N.M.) 1903-1926, 1914-09-27
MRS, HOWARD GOULD
BEGINS LIBEL ACTION

san Francisco. Sept. Exchanges oil
criminal libel made by Mrs. Rather
inc Clemmohs Gould against Harry
Lewis. Chinatown guide. resulted to-
day In the arrest OF Lewis. who was
later released on s500-bond. Lewis
is technically charged with misiie-
meanor libel.
Lewis recently advertised moving
pictures of Mrs. Wong sun Yue, Mrs
Gould's sister. who married a san
Francisco Chinese merchant some
years ago. According to Mrs. Gould,
the advertisement identified Mrs
Wong as the sister OF Mrs. Howard
Gould. wife of Howard Gould. New
York's richest man, who got divorce
from her" Mrs. Gould swears that
this is criminally libellous.
Mrs. Gould was divorced from hci
husband in 1909. she now lives ~
San Francisco.