The Barre daily times. (Barre, Vt.) 1897-1959, 1913-01-04
HEALS WOUND
IN ONE DAY
And Will Mend Broken Leg
Within Four
Days
BIG ADVANCE
IN SURGERY
DR.. Alexis Carrel, Nobel
Prize Winner, Explains
His Experiments

New York, Jan. 4.--The possibility o
healing cutaneous wound in less than
twenty -four hours and repairing frae
tured leg in four or five days is tn,
latest prediction by DIR. Alexis Carrel o.
the Rockefeller Institute for Medica
Research in the current issue OF the
Journal of Experimental Medicine. DR.
Carrel recently received the 1912 Noble
prize for medicine. Since 1907 he has
been conducting series of experiments
chiefly with mixtures OF thyroid extract
| Dir. Carrel commenced his experiments
upon live animals but gave up this pro-
cedure for the laboratory method. lis
sues removed from animals and placed
! in different media in glass jars were
| treated with macerations OF various
strengths made from combinations of
thyroid extract and pulp of the liver,
heart, kidney, spleeIb muscles and blood
corpnscles.
Connective tissues placed in blood
plasma were used as standards to deter
mine the comparative reparatiye prop
critics of the other media. In many in.
stances the rate of cell prolferation was
thirty times greater in the combination
OF thyroid gland extract and organic
maceration than in the blood plasma,
and where an extract made from embry-
onal tissue was used the reparatiye
growth increased forty times faster than
in the standard solution of blood plasma.
Writing of his experiments in the
journal OF Experimental Medicine IN
der the title Artificial Actiyation of the
Growth in Vitro of Connective Tissue"
DIR. Carrel saws:
If the factors that bring about the
of cells and the growth OF
tissues were discovered, it would perhaps
become possible to activate artiiieially
the process of repair. Then aseptic
wounds could probably be caused to
cicatrize more rapidly. If the rate Of
the reparation OF tissues were activated
ten times only, cutaneous wound
would heal in less than twenty four |
hours and fracture of the leg would
be cured in four or five days.
1T is permissible to think that this |
hypothesis is not unreasonable. Jacques |
Loeb in his fundamental experiments |
On artificial parthenogenesis, has DEM |
onstrated that cell division can be in
iuced by slight changes in the compost
ion OF the sea water in which the sea
lrchin's eggs are placed.
1T might even be supposed that SER
ain notifications of the minnieu in
erieur of the tissues of mammals would
oring about the multiplication of their
ellis.
"1n' 1907 and 1905 | began, therefore,
o study the processes OF reparation of
mall cutaneous wounds and the action
# great many substances on the rate
# their eicatrization. Ii was found
hat the prolferation of epithelium and
+ connective tissue was activated under
ertain conditions by dressings made
With the pulp of tissues and organs
For instance thyroid gland pulp de-
osited on cutaneous wounds of the dog
rought about the formation OF exuber-
MT granulations. Applied to bones. it I
reduced a marked thiekening of the
eriosteeum. The external coat of ar
rtery preserved in cold storage in {
fixture of thyroid gland and Loeke's {
Olution, and transplanted afterward (,
Ito a dogs carotid. underwent an enor- !,
lous hypertrophy."