Arizona republican., 1910-03-03

in this fluid and the ultimate value of this method of treatment of carcinoma are Co be finally determined only by continuance and completion of the various correlated series of inVestiga- tous. chemical and biological. now under way. or by such tests as other observers may undertake"
 In very clear language pr. Hodenpyl goes into the details of his cXperi- ments:
 ~lu his deliberations upon this rare ease uf recovery from extensive car cinuma. with residual chyliform as cites. the writer was led to weigh the possibility 'so often discussed, espe- cially in connection with experimental tumors in mice. of the development by the patient of some sort of anti body inimical to the progressive growth and persistence of the tumor cells The alternative hypothesis, which seemed plausible, was that in the processes of tumor tissue forma- tion in the abdomen some physical or physiological disturbance of organic or internal secretions might have oc- lfdhltE lp ttlt tNNuiiihlsANibii VI formation of substances antagonistic to tumor cell growth or existence.
 The ascitic fluid having been freely placed at the writer's disposal to test these theoretical conceptions. d series Of mice. which had developed tumors after the implanting of some of the well known strains of mouse cancer cells. were injected with varying amounts of the ascitic fluid. These injections were made near the tumors, into the tumors and into the body at large. The effect of these injections in brief was to lead to marked necro- sis of the tumors. to d noteworthy diminution in their size or to their complete disappearance.
 After experimental tests of the harmlessncss of the fluid. first in ami mals. then in human beings. injections or the fluid in cases of carcinoma of various types in man were under taken. These injections have been made in small quantities near or di- rectly into the tumors or in large quantities into the veins The gen eral effect of these injections in man has been nearly uniformly to induce a temporary local redness, tenderness and swelling about the tumors. which soon subside. Then occur softening and necrosis of the tumor tissue. which is now absorbed or discharged externally. with the subsequent form ation Of more or less connective tis- sue. In all cases the tumors have grown smaller. in some they have disappeared altogether. In no instance has any tissue in the body other than the tumor shown the least reaction after the injections nor have any systemic effects been manifest even after large venous infusions
 The greater number of the forty seven cases thus far treated were dis rinctly unfavorable. many of them hopeless and inoperable. Many of the cases are still under observation by the writer or by other physicians in and out of New York.
 The records of the cases treated, the technique employed and the results obtained will be placed at the service of the medical profession as soon as time permits, together with the re- suits of various obvious control eX- periments which are now in hand un- der the direction or with the concur renee of the writer In the meantime this preliminary communication IS made. first. in order that the atten- ton of the profession may be called to the possible significance of body fluids from the rare cases of those who have recovered or are recovering from carcinoma: second. to correct the false impressions which may have been conveyed by the premature and unauthorized news items in the daily press. and finally, to secure an oppor- tunity to remind physicians practical Iv interested in this study that the urgency for tkis treatment of hopeless inoperable cases is hardly just either to these patients themselves or to q method from which it is hoped to se- cure new resources and new light through deliberate and reasonable tests"
 Many physicians have long believed that some form of serum treatment would form the basic principle of the cure for cancer when the cure IS dis covered. and it seems probable that Dr. Hodenpyl has blazed the road to