The Washington times., 1903-03-09
HOW DR.. Grille WOULD
BRING DEAD TO LIFE
Describes Experiment Keep
ing ngDecaPitated Dog Alive.
MAKES AN OFFICIAL REPORT
Believed That Discovery May Be Sue
cessfully Applied to
Persons.

CLEVELAND. March 9.-Dr. George
W. Grille. who has been experimenting
with adrenalin as a means OF restoring
life TO persons apparently dead. has
made an official report on the subject
and sent IL 20 a Boston medical Journal.
DIR. Grille recently succeeded in keep
ing dog alive for ten hours and thirty
minutes after IL had been decapitated.
and It is believed that his discovery may
be successfully applied 20 human beings.
In his report he says that the cases Of
shock and collapse are the most urgent
for demanding q means of diminishing
blood pressure. He cites several expert
merits made upon dogs and says that
where he had used adrenaliu II caused
a marked. and. in sufficient dosage. an
enormous rise in the blood pressure.
This rise occurred when the vasomotor
center was proved 10 have been ex-
hnusted, when it was cocainized snd
when IL was destroyed.
Continuing. he says: "It occurred
when in addition both vagi and both
accelerantes had been severed. and the
animal was under tho influence OF Gu
rare. In larger doses a marked inhibi-
tory action upon the heart was noted
This was Immediately relieved by the
injection OF atropine It was finally
found that the most effective method
OF administration was by a continuous
intravenous infusion in salt solution.
varying IN strength from one to 81. 600
or O.00O.
Blood Pressure Controlled.
'Afterthe experimental research seem
ha al
salt solution thus administered could
maintain the circulation with heart
isolated from the nervous system by
section OF both vagi and both acceler-
antes. with the vasomotor center ex-
hausted (cOmpiete shock. and with the
muscular system paralyzed with Gu
rare. it followed that il these observa-
tions were correct dccapitated ami
NAL might be kept alive during Ger
tain period of time. An ordinary lab
oratory dog was decapitated Adrenalin
and saline solution were Immediately
end continuously administered. It was
found that the blood pressure could be
controlled at VIII. The beheaded ami
NAL lived ten and one-half huIrs. and
finally died Of air emboil. produced by
the artificial respiration On beheading
animals the primary fall in the blood
pressure was approximately the same as
in profound shock
Experiment on a PGtient.
But one clinical application OF ad-
renalin when the vasomotor center was
exhausted has been made In this in
stance patient who was dying was kept
alive for nine hours by the continuous
administration OF adrenalin and the ap-
plicatiOn of external pressure. 1t is TO
be remembered that. owing TO rapid
oxidation in the tissues, adrenalin is
more effective when given intravenously
and. since IL is even more rapidly oxi-
died in the blood. it should be given
continuously Il is found 70 be most
conveniently administered in saline So
luton from a burette, the rate OF flow
being controlled by pinchcock attached
to the rubber tube. The circulatory phe-
nomena should be under continuous OBJ
seTvatiOn. Great caution must be exer-
cised in the administration OF adrenaIin -