davidaulloa/AmericanStories huggingface dataset:
Amador ledger., 1901-09-20
Barometric Bees.

Whoever observes these interesting
insects finds 1t easy enough to foretell
exactly the kind of weather to be ex-
pected. At least this is the opinion Of
many raisers of bees.
Generally the bee stays at home
when rain is in the air. When the sky
Is simply dark and cloudy, these busy
workers do not leave their dwelling all
at once. A few go out first, as though
the queen had sent out messengers to
study the state of the atmosphere. The
greater number remain on observation
until the clouds begin TO dissipate, and
iG is only then that the battalions en-
tire rush out in search of their nectar.
A bee never goes out in fog, because
it is we'll aware that dampness and
cold are two fearsome, redoubtable
enemies. We do not mean, however,
that the bee Is meteorologist in the
absolute sense of the word. Its clever
ness consists in never being taken I'M
awares, for 1t possesses untiring vigil
lance. Often one may observe the sud-
den entrance of bees into the hive
when a dense cloud hides the sun and
even though the rain is not in evidence.
ST. Louis Globe Democrat.
Amador ledger., 1901-09-20
TUESDAY


When Hazen S. Pingree was coming
into prominence in Michigan politics,
he was in Washington one night and
strolled through the corridors of VIII
lard's hotel, which he had not visited
since war times, when it was the popu-
lar rendezvous of the city, political,
military and otherwise. A friend intro.
duced him to Colonel Mosby, the old
guerrilla chieftain.
"W'hy, hello, colonel" said Pingree in
his bluff, offhanded way, just as If he
was in the habit of meeting Mosby ev.
cry day. Il have not seen you for %
years, but | remember very well the
last occasion when we met"
"Ah," said the Virginian politely,
what incident recalls it to your mind7
really fail to remember you, much to
my regret"
"Oh, WELL" said Pingree, "you would
not be so apt as to remember the day.
was captured by your men. and, hap
pening to be wearing very good, near
ly new uniform, you confscated 1t on
the spot and gave me your old ragged
butternuts. But that's all right Alps
fair in love and war, I know. Let's
have cigar"
Without word of protest Mosby &C.
cepted, and long friendly chat fol-
lowed.
Amador ledger., 1901-09-20
FoILED BY HIS OWN TRICK.
Scheme For Selling a Farm and It's
Dramatic Climax

Some years ago." said the nara tor,
ian oil boom hit Litchfield, Ills, and
everybody for miles around was seen
shifting for oil and every. stranger sus-
pected of being an expert looking for a
good thing. An old farmer named Loo
mis- had big place three miles out of
town, which would have been q fortune
for him had he not been possessed of a
han1a for swapping, manifest in a per-
Onial attempt to trade off his land
for twice its value
when the boom was at the top notch,
Loomis received a visitor who took So
much interest in the farm, so liked its
appearance, location, etc, that the old
farmer scented petroleum man and
saw visions of incalculable wealth:
but, being shrewd man, LOOMS did
not care to take any unnecessary
chances with Providence, and on the
quiet he sent the hired man out the
back way with orders to dump the ker-
osene can into the veil. The visitor
liked the entire place, inspected the
barn, the chicken yard and then, as If
by chance, asked for drink of water.
LOOMS was waiting for that and
hauled up a trimming bucket before
the mans own eyes and poured him out
a gourdful of liquid with a fine, opa-
lescent scum upon it. The visitor smell
ed the stuff, tasted it, made WY face
and asked if the water was always like
that. ooh, yes said Loomis, but you
soon get accustomed to the taste, and
our doctor says this is the finest water
on earth for the stomach We'll,
am ding DANCED if I'll ever get used to
it, was the unexpected response L
am looking for farm, not an oil well,
and if 1 have got to haul my drinking
water three miles from Litchfield
guess I'd rather buy nearer town.
1T took Loomis six months to get the
taste of oil out of his well, and by that
time the boom was over and nothing
was left of the oil craze but rotting der
ricks and abandoned shafts."-New Or
leans Times-Democrat
Amador ledger., 1901-09-20
BkI'ey-ShOf
For Tiger.

No use to hunt tigers with
bird-shot. 1t doesn't hurt the
tiger any and it's awfully risky
for you.
Consumption is a tiger
among diseases. 1t is stealthy
but once started it rapidly
eats up the flesh and destroys
the life. No use to go hunting
it with ordinary food and med
icine. That's only bird-shot.
1t still advances. Good heavy
charges of SCOTS Emulsion
will stop the advance. The
disease feels that.
SCOTS Emulsion makes the
body strong to resist. 1t
soothes and toughens the lungs
and sustains the strength until
the disease wears itself out.
Send for free sample.
SCOTT & BOVINE, Chemists, 400 Pearl ST., N. Y.
sse aud s,eo; al druggists,
Amador ledger., 1901-09-20
Where He Forgot Himself.

eve are seven," laughingly quoted
the man who was an applicant for life
insurance when asked to give the num-
Der of children in his fathers family.
"And their names?" asked the exam
lining surgeon.
"Well, there's Albert, Addie, Henry,
Laura, William and Dora and-and"-
The surgeon looked surprised, and
the applicant looked foolish.
Then he began again, There's Albert
and Addie, and Henry and Laura, and
William and Dora, and-and"-
The surgeon announced that these
were only six. The applicant acknowl-
edged the corn and went over the list
again and again, invariably baking
after the sixth name. Then bright Of
flee boy looked up from his work, with
grin, and said;
"Say, haven't you left yourself out of
the COUNT"
The surgeon seemed relieved, the ap-
plicant seemed more foolish than ever,
and the office boy grinned on at his
work
"That certainly was one time" final
ly commented the applicant, that
completely forgot myself" York
Times.
Amador ledger., 1901-09-20
A WORTHY SUCCESSOR.
Something New Under The Sun. /,

All Doctors have tried to cure
Catarrh by the use of powders, acid
gases, inhalers and drugs in paste form.
Their powders dry up the mucuous
mem branes causing them to crack open
and bleed. The powerful acids used in
the inhalers have entirely eaten away
the same membranes that their makers
have aimed to cure, while psstes and
oiutments cannot reach the disease.
An old and experienced practitioner
who has for many years made close
study and specially of the treatment of
Catarrh, has at last perfected treat
ment which, when faithfully used, not
only relieves at once, but permanently
cures Catarrh, by removing the cause,
stopping the discharges, and curing all
Inflammation. 1t is the only remedy
known to science that actually reaches
the afflicted parts. This wonderful
remedy is known as 'Snuffles the
Guaranteed Catarrh Cure, " and is sold
at the extremely low price of one dol
lar, each package containing internal
and external medicine sufficient for a
Iull mOubH GfedtGu6nb anu everything
necessary to its perfect use.
"Snuff1es" is the only perfect
Catarrh cure ever made and is now
recognized as the only safe and positive
cure for that annoying and disgusting
disease. 1t cures all Inflammation
quickly and permanently and is also
wonderfully quick to relieve hay fever
or cold in the head.
Catarrh, when neglected, often leads
to consumption-'Sn uffies" will save
you if you use it at once. 1t is an ordi-
nary remedy, but complete treat
ment which is positively guaranteed to
cure Catarrh In any form or stage if
used according to the directions which
accompany each package. Don t delay
but send at once, and write full particu-
lars as to your condition, and you will
receive special advice from the dis
cOverer of this wonderful remedy re-
garding your ease without cost to you
beyond the regular price of ''Snuffles"
the Guaranteed Catarrh Cure"
Sent prepaid to any address in the
United States on receipt of one dollar.
Address Dept. Edwin G. Giles & Com
pany, 1880 Market street, Philadelphia.
Amador ledger., 1901-09-20
Apple. the Diet For the sedentary.

Apples are very wholesome and di-
gestible. They contain considerable
potassium and sodium salts, magnesi-
um, little iron and about So per cent
of water. Apples, being rich in pectin,
form readily into jelly. They also con-
tain free organic acids as well as salts,
such a malates, citrates and tartrates.
They are quite laxative, more SO if TAX
en- late at night or early in the morn
ing with a glass Of water. Their nutri-
tive value is not much, as they are
largely composed of water For in
valids apples are best when baked and
eaten either plain or served with cream.
Ledger Monthly.
Amador ledger., 1901-09-20
$ DREAMS WHICH HAPPEN.
A Robbery That Was Witnessed by
Woman During Sleep

Robbery That Was Witnessed by
Woman During Sleep.
A lady spending the summer in the
country, some 20 miles from her city
residence, dreamed that the latter was
robbed, she herself being a witness of
the robbery. In her dream she saw two
men, one of whom limped, in the act
of rummaging some trunks in the hall.
A candle stuck by means of its own
scene with dim light
After finishing their work with the
trunks the men went up stairs TO a
closet, from which they removed cur
tains and hangings stored for the sum-
mer months The dreamer observed
that they overlooked her most valuable
curtains, which had been placed well
back on upper shelves.
Suddenly she seemed to he transport
ed to her birthplace at Auburn. n. Y.
where she especially noted the bronze
figure of an Indian which surmounts
the prison edifice.
AT breakfast the next morning she
related her vivid dream to those pres
ent. five of whom are now living and
vouch for the fact. Subsequently it
was found that the city house had been
entered and robbed. On the newell post
We're the marks of the candle. The
curtains had all been taken but the best
set, which were found where the dream
er had seen them.
Suspicion was directed to a painter
who had been at work on the house,
who was lame and who disappeared
Immediately after the robbery. Inves-
tigation of this mans character showed
that he had served term in the Au-
burn neutrality-suspicious. Culture.
Amador ledger., 1901-09-20
BOOK MAxIMS.

1t is better to give book than to
lend it.
Do not bite paper knife until it has
the edge of saw.
Do not cut books except with a
proper ivory knife.
1t is ruination to a good book to cut
1t right through into the corners.
Books are neither card racks, crumb
baskets nor receptacles for dead leaves.
Never write upon title page or half
title. The blank fly leaf is the right
place.
Do not turn the leaves of books down.
Particularly do not turn the leaves of
books printed on plate paper.
If you are in the habit of lending
books, do not mark them. These two
acts together constitute an act of indis-
erection.
Books were not meant as cushions,
nor were they meant to be toasted be-
fore a fire.-Arthur L. Humphreys in
Private Library.
Amador ledger., 1901-09-20

The piercing eyes and intense ex-
preston of Henry Irving once had the
effect of making fellow actor alto
gether forget that he was on the stage
at all. 1t occurred in Manchester dur
ing performance of Macbeth" and
in the scene where Macbeth says to one
Of the murderers, There's blood upon
thy face!' Irving put so much earnest
ness into his words that the murderer
forgot his proper answer ("'Tis Ban
quo's, them and replied IN startled
voice: rs there? Great Scottw He
fancied, as he afterward said. that he
had broken a blood vessel. - Ledger
Monthly
Amador ledger., 1901-09-20
Wait Till He Sees You.

A Zulu chief, when you enter his hoy
ell, remains silent for some moments
and seems quite unconscious of your
presence. At length he says in tone
of grave dignity, "Ge saku bona" q
see you), to which you reply in the
same way. The longer he takes to "see
you" the greater man you are supposed
to be, and until you are thus seen"
you must keep silent and appear as
much as possible not to be there at all.
Amador ledger., 1901-09-20
Hotel Arrivals.
NATIONAL HOTEL.
FRIDAY


B. E. Heady, F. W. Winston, J. J.
Collins, Walter P. Porey, San Fran
cisco; II. B. Nermount, Virginia; p.
Ballard, lone; E. B. Stone, Oakland
S. H. Palmer, Tabeaud; j. Williams,
Antelope; I. A. Stirnman, Belmont.
SATURDAY.
A. G. Schofield, S. E. Co.,; Arthur
z: Ross, San Francisco; v. w. De-
Marsh, A. DeMarsh, Stockton; F. ].
King. Moreland; Mrs. Leeper, Angels:
a. j. Darroh, Mill Creek.
SUNDAY.
G. Fl. Richardson, w. H. Sigourney.
F. Mason, Joe Moreis, r. Brown, E.
lngraham, j. S. Thomas, San Fran
cisco.
MONDAY.
S. M. Smith, S. E. Co.; F. B. LIE.
Moin, Drytown; L. H. Page, Ontario:
Ed. Hamrahan, G. F. Qaighey, J.
Hughes, Geo. Gray, Alex Kennedy, C,
Gallagher, San Francisco; Mrs. 4. F.
Peter, Mrs. N. E. Wilder, San Jose:
): II. Kelley and wife, Weaver; L. Nc
kenzie, Volcano; E. B. Stone, S. H.
Palmer, Oakland.
Amador ledger., 1901-09-20
BIG ENOUGH TO HIT.
So Thought the Small Boy, but tn,
Man Thought Differently.


Man Thought Differently.
He wasn't very big, but he was
sturdy little chap with face that bore
the marks of much thinking and pre-
mature responsibility. 1 learned after
ward that he was supporting a crippled
mother and an Invalid sister who had
been left helpless in the world by the
death of her father He might have
run away from home and evaded the
responsibility, but he didn't think of
Vt. He just sold papers.
At the loop on Fifteenth street
crowd was gathered, waiting for the
evening cars. A ragged young girl was
selling flowers at the Fifteenth street
end of the waiting station when man,
rushing to catch his car, knocked her
against the side of the building. With
out stopping, probably not having no.
ticed what he had done, he continued
his rush, when the boy stepped in front
of him defiantly.
Say, what do you want to knock a
girl down for? Hit me. I'm big
enough"
The man paused in surprise and then
glanced around. He saw the flower
girl picking up her wares and under
stood. Without moments hesitation
he went back to her, gave her enough
money to make her eyes sparkle with
JOY and said:
IN sorry, my dear, that hurt you.
didn't see." Then, turning to the boy,
he continued: you said you were big
enough, young man, but you're a great
deal bigger than you think. Men like
you will have lot to do with keeping
this old world in a condition of self
respect"
Then he caught his car, and the boy
and the girl stood there wondering
what he meant.-Denver Times.
Amador ledger., 1901-09-20
Church Notice,

ST. Augustine's Mission, room situat-
ed on Court street. Services as follows:
Every 1st and Sd Sunday, services at
II a. m. Every I'd and 4th Sunday,
services at 1880 p. m. Sunday school
every Sunday at p. m. The Young
Peoples Society of Spiritual Growth
will meet every Sunday, at $50 p. m
If WILLIAM TUSON, Rector.
Amador ledger., 1901-09-20

Judge -, one of the great lawyers
Of the last generation, charged a client
a retainer Of $1,000 in an important
case, but the parties got together next
morning and settled the suit before the
judge had opened a book or written a
line concerning it. His client called to
see If he would not refund part OF the
money. The lawyer seemed surprised
at the suggestion. "Refundp' he ex-
claimed. Refund. did you say7 My
friend, that Is kind of fund unknown
to the legal professlonT-New York
Press.
Amador ledger., 1901-09-20
GninE All The Tire.

Il see Wisconsin man "r-.s TO
have solved the perpetual mo; prob
lem
That's nothing. | have .el Of
Il perpetual motion macl'- my
house now
Does Ii work successIal.E
From the stand loH t;etual
alJtian. you bet II :
Have you given 4, a ,4le"
Sure"
What do you call it,"
Jimmie and it was years old its
last day."-Chicago Post.
Amador ledger., 1901-09-20

Miss Singer-I saw in the paper that
there is to be an entertainment for a
"musical orphanage" Pray, what may
a musical orphanage be?
Mr.. Kenitall-I can't say positively
you know, but I imagine it must be g
child deprived of it's native air.-Har
per's Bazaar.
Amador ledger., 1901-09-20

A gallon of distilled water weighs
$3.50 pounds. and there being four
quarts to the gallon and two pints to
the quart, and 16 fluid ounces to the
pint, and two tablespoonful to the fluid
ounce, and four teaspoonfuls TO the ia
blespoon, and 45 drops TO the teaspoon,
a drop of water weighs 0.0001S057
pound, slightly more.
Amador ledger., 1901-09-20
In the Museum.

"The legless man is always putting
his foot in it," observed the living skel-
eton to the snake charmer.
"What has he done nowT
Last night we were having friend
Iy little game, and he asked the armless
wonder to take a hand" -Baltimore
American.
Amador ledger., 1901-09-20
New Tricks.

Wimbieton-Hello, old man! Have
you taught your dog any new tricks
lately?
Quimbleton-Yes; I've been teaching
him to eat out of my hand. He ate
big piece out of 1t rday.-Harvard
Iampoon,
Amador ledger., 1901-09-20
A. H. kUHLMAN
Contractor and Builder

VIII do work in any part OF
Amador County. II you want
to build, send note to Jackson
PostOffice and ! will call on you.
Estimates furnished without cost
on any kind OF building. VIII
make plans and specifications for
you. mar2ti
Amador ledger., 1901-09-20
GLOBE HOTEL.
THURSDAY.

A. B. Summers, Plymouth; John
Hall, Edison Waragraph Co.; A. Diaz,
Miss Bell Diaz, West Point; Mrs.
Evans, Middle Bar; Miss Bell Stewart.
Butte City; A. M. Gregg, Woodland
L. B. Lewis, A. G. Lawrance San Fran
cisco; William Hess, Jackson; Thos.
Conan, West Point.
FRIDAY.
Fayette Mace, lone; John Burke.
Joe Podesta, Arthur Hamrick, Jack
son; Allen H. Blanchard, N. E. Hunt
ingtOn, j. w. Tressford, San Fran
cisco; Henry Morno, Fresno; j. Earle.
Spokane, Wash; E. F. Page, Sacra-
mento.
SATURDAY.
N. B. Graves, San Jose; S. Witko-
wski, Will Parkison, A. A. Dudley,
San Francisco; j. E. Burt, Pasadena;
Thos. Scully, lone; G. E. Brown and
wife, Gowannis Mine; B. A. Legget,
Los Angeles; Daniel Mack, Electra
Henry Lasswell, Frank Hewett, jack
son; VIM. Hewett and wife, Miss Sell
kirk, Miss Tibbighan, Suffer Creek;
Burt La Mont and wife, New York.
SUNDAY.
j. F. Parks Jr, Joe Cademartori, F.
A. GOebel, jackson; G. W. Mitt,
A. c. Smith, A. Eslaine, Bullardo Bar;
Fleming Bros, Kansas City; A. E..
Eigenmaun, Tom Joy, San Francisco;
James Fontenrose, Sacramento; Carl
Bach, Mokelumne Hill; Harry Cuwella,
New York; Milton Bearce, L. A.
Bearce, Defender.
MONDAY.
E. E. Allen, Bangor; E. B. Moore,
w. j. MCGEE, Porter Clare, Suffer
Creek; P. L. Cassinelli, Buffalo, New
York; A. B. Mclaughlin, John F.
Clute, Volcano; j. L. Sargent, Middle
Bar; c. L. gilbert, Jackson; A. B.
Summers, Plymouth; ]. Noonan, San
Francisco; E. Ingram, Arkansas; ".
A. Peary, lone; F. w. Parker, Yer.
mont; W. B. Burkhalter, Santa Rosa.
TUESDAY.
Fleming Bros, J. Welsh, Edison
Warograph Co.; Milton Bearce, De.
fender; j. Noonan, Mrs. r. NJ. Horna.
day, San francisco; John Burke, John
Fontenrose, Buzz Watkins, Jackson
w. G. hickman, Stockton; Louis
Gardella, John H. Rodgers, Bear
River.
WEDNESDAY.
Jas. Mcbride, J. G. Fogert, P. C.
Hambric, San Francisco; James Fon.
tenrose, G. Marelia, jackson; Mrs. r.
E. Shealor, Humboldt Co.; James
Casey, w. S. Coulter, Mike Coogan,
r. ]. Casey, San Andreas; NJ Ham
mer, lone; Mary L. Weitz, Farming
ton; r. Morgan. Suffer Creek.
Amador ledger., 1901-09-20

Thirteen dollars and a half seems
high price for such a comparatively
short trip" said the man with the
travelling bag 10 his hand.
we thought people would rather
pay that than S13," replied the agent
of the steamer line with an explana-
tory snd apologize cough.-Chicago
Tribune.
Amador ledger., 1901-09-20

Alfonso Ginocchio, S. G. Spsgnoli John Strohm,
Frederick Eudey and Alex Eudey of Jackson
SAFE DEPOSIT.-Safe deposit boxes can be
rented from the Bank Of Amador County at the
small expense of IS cents month, thereby Sc
curing you against any possible loss from FIRE
or otherwise. Don't overlook this opportunity
of protecting your valuables.
SAVE MONEY-PatroniZe home inStitu-
ton Send money away through the Bank Of
Amador County; ynu will save 10 per cent and
upward over postofioe or express. Money sent
to all parts OF the United States and also all
parts of the world. We have the latest quota
lions on foreign exchange.
SAVE MONEY-It doesn't cost anything TO
deposit money in the Bank OF Amador County.
They receive deposits from s5 up Commence
the new year by opening up bank account.
man or woman with q bank account has
financial standing. Don't bury your money
when you die 1t can't be found and you are liza
BILE TO be robbed while alive
Amador ledger., 1901-09-20

If a mother Is at all clever, she can
train her baby by the time it is 6 weeks
old to cry to go to its father as soon as
he comes in the house.-Atchison Globe.
Amador ledger., 1901-09-20
Working Night and Day.

The busiest and mightiest little thing
that ever was made is Dr. Kings New
Life Pills. These pills change weak
ness into strength, llstlessness into en-
ergy, brain-fag into mental power.
They re wonderful in building up the
health. Only 25c per box. Sold by
D. B. Spagnoli.
Amador ledger., 1901-09-20

'Some people" said Uncle Eben.
doesn't seem TO take no special inter
est in tcllin de troof 'ceppin when it's
sumpin disagreeable." - Washington
Star.
Amador ledger., 1901-09-20

Don't fail to read the advertisement
on another page, about the SIS, 900
prizes the Ledger readers will get il
they want to try for them.
Amador ledger., 1901-09-20
She Was the Ghost.

"a certain lady and her family" says
Sir Mountstuart Grant-Duff In his
DIARY" "hired a place In Scotland
which was haunted by the ghost Of o
woman who was to be seen constantly
at night wandering through the rooms
anu passages. When the family arriv-
ed, the lady was much struck with the
place and said, Il must have been hero
before, for 1 know this place so well,
only there ought to be two rooms here,
and there is only one
'The agent replied that within a few
weeks the owner had caused partition
to be taken down and made the two
rooms into one, Still the lady was puz-
zled at her knowledge of the place, till
she remembered that 1t was a house
she used to go to in her dreams
"Well, some time passed, and the
agent was up at the house again. when
the lady complained that one part Of
the contract had not been fulfilled.
They had hired a house and ghost FOR
the summer. and no ghost had she seen.
The agent replied: of course not, be.
cause you are the ghost. We recognized
you the moment We saw you.'"
Geu. w. Lane, Pewamo, Mich,
writes: "Your Kodol Dyspepsia Cure
Is the best remedy for indigestion and
stomach trouble that ever used. For
years 1 suffered from dyspepsia, al
times compelling ma 10 stay in bed,
and causing me- untold agony. 1 am
completely cured by Kodol Dyspepsia
Cure. In recommending 1t to friends
who suffer from indigestion | always
offer to pay for it if it fails. Thus far
l have never paid" kerr's Phar.
macy, Jackson.
Amador ledger., 1901-09-20
LEDGER'S CLUBBING RATES.

Ledger and Daily Call, one year .......s7 so
Ledger and Weekly Call, one year ....... 8 go
Ledger and Daily Bulletin, one year 800. so
Ledger and Semi Weekly Bulletin, yer 4 20
Ledger and Weekly Bulletin one year 3 80
Ledger and Daily Chronicle, one year. 7 10
Ledger and Weekly Chronicle, one year go
Ledger and Weekly Examiner, one year. 8 80
Ledger and Daily Examiner, one year e. 80
Ledger and N. Y. Weekly Tribune, yer 90
Ledger and n. Y. Tri-Weekly Tribune, ly 8 so
Ledger and Cosmopolitan Magazine, yr 8 IS
Ledger and S. F. Weekly Post, one year. 8 90
Ledger and McCalls Magazine, one year Q rs
Ledger and st. Louis Globe Democrat, 1y 90
Ledger and Twice a Week" one year d. 90
AFThe above rates are strictly in advance.
Amador ledger., 1901-09-20
BANK Of AMADOR COUNTY

Incorporated November, 1895
Capital Stock : :: $4,000
Amador ledger., 1901-09-20
FRIDAY,

Fayette Mace, lone; John Burke,
Joe Podesta, Arthur Hamrick, Jack
son; Allen II. Blanchard, N. E. Hunt
ington, j.. w. Tressford, San Fran
cisco; Henry Morno, Fresno; J. Earle,
Spokane, Wash; E. F. Page, Sacra-
mentO
Amador ledger., 1901-09-20

Some Suggestions About the Plumb
ing and the Care That Should Be
Exercised In the Avoidance Both of
ENpense and Disease