The sun., 1899-07-08
NEUTRALITY-SUSPICIOUS.
FIRST CASE TREATED WITH DIR.
ALVAH H. DOTY'S SPECIFIC

Improved After Injections OF tho Anti
toxin-Experimentsto 20 Bo Made in Mexico.
II Otcar F. Lackey. civil engineer. OF Balti-
more. who fell Ill OF yellow fever on tho trans
port Mcclellan on the way from Santiago to
New York. and is now Swinburne Island.
recovers his health he will have had an ex-
perience in which the whole world will be in
terested. Tho injection into his system on
Thursday night OF the serum. which may be
called yellow fever antitoxin. prepared by DR..
Alvah il. Doty on the elimination OF expert
ments extending over eighteen months. was the
first administration Of this substance to hu-
man being The course of Mr.. Lackey's disease
Immediately after the injections and yester-
day indicated tho most beneficial effects from
the treatment. Whether tho favorable symp-
toms we're resultant from the injections or were
merely incidental to the natural course OF tho
disease DR.. Doty would not say. Although
Gratined In high degree and hopeful. as was
90 be gathered from his conversation. he de-
plored any tendency to premature claims Tor
his serum. Even upon Mr.. Lackoys recovery,
II he shall recover. DR.. Doty will not assert tho
yindcation OF his theory. He desires reports
on half hundred cases before declaring its
value. In one important respect. however the
case Of Mr. Lackoy will mark severe test OF
the specific. II such it shall prove. for the
serum is intended for use as preventive in
the initial stages OF the disease. and II was not
until the third day of the fevcr's progress that
the New York Health Onlccr had opportunity to
administer 1t to this patient.
Dr. Doty went down to Swinburne Island
early on Thursday evcning.'af the patients
and suspects from the transport had been
taken there. not expecting TO uso the serum
either on Mr.. Lackey or on Miss l.. C. Glen
denim. who were I'll Of yellow fever. but intend
ing to use It on John Ferguson. discharged
soldier, who was one of the SUSPECTS t. Fcrgu-
son should develop unmistakablo symptoms OF
the disease. He found when he got there that
Fergusons symptoms did not indicate the
fever Mr.. Lackey. on the other hand. was in
a very bad condition. The process OF re-
moval from the transport had produced
bad effect on the patients. whom 1t
had been necessary to wrap in tarpaulins
when they were taken from tho ship to
the island Mr.. Lackey labored under n good
deal Of anxiety. He knew that he had yellow
fever. He asked DR.. Doty to tell him frankly
his condition. DR.. Doty told him that it was
serious, as are all cases Of yellow fever This
Mr.. Lackey already knew. having spent some
time in Santiago. His mind was clear and
active. despite the fearful headache and other
discomforts of his disease. llei an intelligent
young man. % years old. graduate Of Johns
Hopkins University. and comes OF family
well known in Baltimore. Among the first in
quiries for passengers On the MCCLELLAN after
her arrival here were some from Baltimore Tor
him In his profession of civil engineering he
bad been doing some work at Santiago under
Dr Doty told Mr.. Iackey Of the serum. OK
planning the cirrmmstinncSs G Of |. is preparation:
"H hat he wo 3 ht1 @o aS ysf
one, without the PATIENTS consent
ca and a Dr. yo bdy t9s to ma 9 hs ri
Injection Of tn" serum His assistant. ssh Pr
logical hureauof TIL" Quarantine station. was
with him Mr.. Lackeys pulse was down to ~.
his temperature was 1888, and he was, unable
were in such state Of congestion that who
they failed to eliminate the toxins from his
blood the excretions from them showed nearly
some of the chief sustaining clements Of the
blood. Altogether. II" was in bad way.
At II O'Clock tn" physicians injected twenty
FIVE cubic eG1tmftTrss Of tGs m M serum in9 the
Careful observation. with hourly records of
pulse and temperature. respiration &C. failed
tTary e' the effects Of the injection appear"d dis
tinctly favorable. At = o'clock a larger guam
Sl @ornns tho % was rex
peated with further increase of the dose.
until hs de na5snt ha2 srsyed f
Doty decided to wait twelve hours be-
os ynfS tie anSteSr on tho In t9s
was continued. The patient, who had been anx-
iops. was more cheerful: lie he asked for some
which he retained. He had not been able to
drink water While THE Sun reporter was call
the swnbuTne Island Hosri,aI, saving that "
vichy and ice, His pulse had advanced
IL tnre e. had ' gone ne down TO i55i :. lie was DONG
well. and there was reason to hone that the
said he could tell better twcnty-four hours
later. In the meantime Mr.. 1:arkey. is receiv-
ton "a and careful nnrsng. nor has he received
any since arriving here
times purgatves and large quantities OF water,
or some other M things; , are given to patients the
chiefly in Watching for the time when heart
failure occurs aud then seeking 70, stimulate
organ organ fails to respond to the most powerful
serum br'' Doty has been able to procure
from horse made immune by inoGulatiion
proves itself specific the whole treatment Of
fellow fever patients VIII be ,r"y@IutionzG,d;
doctor experimented on. and he has had only
one to treat and draw upon formonths: 1t was
one horse would prove more adaptable to the
treatment and would yield many times more
OF the serum than another, and some would
another horse, which is being ilnmunzcl. The
ncndnr the "xperm"ns erH with snme" prs
Il similar to that by which the diphthcra anti
BY a coincidcncc DR. Barnard J.. Baker OF
Charleston. s. G.. whom DR.. Doty sent to Vera
Cruz, Mexico. with supply of the serum,
rived there on ThurSdaY evening. Dr. Baker
took enough OF the serum with him for twenty
cases; BY last Wednesdays steamer DR.. Doty
sent him enough to treat thirty moro patients.
60 that he will be able 70 rrport on nifty cases
Vera Cruz is a home of tho yellow fever. ono of
the cities Of the tropical hclt where vuIturcs
perform the oflicG OF = health d"rartm"nt, as
travellers can attest. Because the disease is
endemic in Vera Cruz and patients may be
reached while in the early or even the prcm-
mary stages of il, the city Offers Just the op-
portunities for DR., Bakers mission, and on his
experience and reports much Of the future use
and field of DR., DOty's serum will depcnd.
Meanwhile the case of Mr.. lnck"y will sup
ply tho only obtainahle data. When that has
advanced further Dr. Doty will make a tochni-
cal report on It, hut professional considerations
prevent him from giving to the public his OBJ
servatons in detail in anticipation Of tho event
1t may be said here that If no other case of tho
fever appears at this port-nonc il likely to ap-
pear and certainly none is likely to get beyond
the Quarantine station-proba bly, no more of
the serum will be made by Dr Dnty. II is not
his purpose to continue the manufacture. hut