The sun. [volume] (New York [N.Y.]) 1833-1916, 1898-07-17

- W kSA Wv VI NAN
In the Interior. on the contrary. the disease
the manner Of lie IN tropical ii l'G co9ntrfcs. and
The mortality among patients then rises TO SO
OF " per cent, and at Csmpinas. AZ RE Clare.
denies can Be compared S only to pG IKE ies saS larry
lnyaslons OF the plague IN, the middle ages:
fhS st S9SS nl SS6 p ana sanitary Snt SqSts tTLbsS Of
this serious condition of things. wished thatmy
first experiments in human scrotherppy should
to % obtain p . definite " opinion n rsn 20 theft Ro SSISS.
Ar official committee of distinguished hyEien-
the experiments. The place chosen was San
SSTlos DE- Pln5Hl; a city q obogt n. 900 !nbabi;
the sea. eight hours by rail from the city Of Sac
At San Carlos yellow fever to-day is endemic.
II has driven, out all the inhabitants, who are
looking for shelter in tho country around, and
is sprs ,IIl its raSyages am9ng the few work.
which ! have, already made public IN q lecture
9 9GsIsf' sq SR HSt COM l1ss 81 'a 81 Esap FsSi o. i bee
fore the Medical and Surgical Society Of that
The serum which 1 was about to employ and
In these first experiments came. as | have said,
from three animals. 1 had already long before
found Il a Very remarkable power had also
tried i on man. with a preventive object, by
Monteyldeo and while stayed at San Carlos
do Pinhal. The injections IN quite large doses
hated aSainst yellow fever erV was t tolerated. BY sSt the
human subject perfectly and could. conse-
treatment Of the disease. The OK serum or +
serum. as l am accustomed to call il. had
shoyn in the exporiments on animals a quite
t2nly as q prophylactic,
On Teachipg San Carlos we found very few
only patients in the hospital at first were a boy
father had already died OF yellow fever. The
W little patients presented the CHARACTERISTIC
SySmis' Th o. f boy s WSs is tb hnei sscnna inc 5sv oia aSS
girl in, the third day Of. the disease. They were
immediately subjected to treatment, and the
results were almost immediate. Fever and al
became milder. and the two. children. became
course. Of the sickness by injection a very small
QUANTITY. OF serum the little girl twenty. cubic
18th Of February six therpatients were treated
IN the same way; one. OF them; anuric and al
entea no r 81 ffn ss Was t u be e0s e4pects sHpf the
on the fourth day. of, the other five. four be-
cidents OF more or less Importance. and having
Sealled for a very prolonged serum treatment;
illness with cerebral LESSONS.
The first set OF experiments. two deaths and
efficacy and. results Of. the serum Treatment
With small doses; will say at once that it was
uelnOnSgrdteQ Jnat these doses were INSULT
cient., Moreover, we became convinced that IL
Injection sif nat at o s@SS6 By the IN tfi fSE Iniest ses 0G 3Se Si 81
transitory suspension. and that the organism.
already a prey to toxic p%henSSmena. became
In the cases terminated BY 2 cure after an
out exception. aecempSnnies W as q sort as Of s;n @,ih,
reaction the first injections OF serum. especially
ST,a senn they "a are made n into the veins, the fever
sisniiisant ana passing oscillations, At. the
the accident OF The, third PERIOD Appearing.
constantly accompanied and characterized our
serum treatment. From the point Of view OF
important itt fact Which I OCCURRED ft SaDSSai AMONG Ene nR
almost all the patients submitted, to serum in
%|ections. In most cases we noticed an extreme
" favorable influence on renal secretion. so
that at times an nctual polyuria. was produced.
Even In the eases terminated By death anpria
at San Carlos the dominant. early ana fatal
tS "dBii direct a az eim essre III ep By R the spsc II Sf tre 7
ment on the most insidlous and most feared
In the Course Of this nrst series Of inVestiiga-
tons another phenomenon attracted our atten-
ton. For som patients: On account OF their
results obtained by entertainments injections. we
had the idea OF making use Of interyeaal injec-
lOIIb vi SCIulhE 4h0 AOIIh. III UlS IIltbo IL
jections are given 1--WE. gave them always on the
superficial veins Of the forearml is Sc. simple
and SO sure that 1t should not be considered as
exceptional In the practice Of medicine.
The action OF tntervenal injections OF yellow
t estins serum imm az fhf RS' aiter lie Il e1If nisetiGn ia eynn
OF Q weak dose Fifteen cubic centfmetresl the
patient remains quiet; after a few minutesa
served. especially about the pectoral region and
the face the conjunctivg become. injected, tho
Ing the norma lumber q eats The patient artiien
feels a sensation, Of heat in his head. has q few
attacks OF coughing. sometimes nausea, and
presents at several points OF the body a slight
Eednes9 OF the skin like O nettle rash. Some
h9T{s later Snwu the 0o ten tsarTSosra T dSis t and is
This r~eactlve rising is followed, in most cases.
by an enduring lowering Of the fever and by q
ProitinG by these preliminary observations,
my colleagues and | agreed to give q somewhat
mont Of patients. We determined to intervene
quickly With large doses Of serum introdacinG
PRODUCING at q single operation into the dis
eased organism the quantity OF serum .neces-
s S1ry, to stop Ft the S sSSFFss Of w %in;seti lon c a. IL be- 3cr
convenience, the intensive method, gave us
results much superior TO the othor. results
I %aaftn as SS de ma I iSoh upon LOT 'hO moment al
think ,it necessary to state. however. that
must BIO given with certain precautions. owing
TO the fact that all patients have, not the same
OF the disease are much more SENSITIVE and
respond generally much more enerGetlcally and
violently than those who are In q moro adj
vanced stage. Aside from this difference In
reaction. which may be easily explained. but on
that certain Individual constitutions and that
certain persistent, organic LESSONS. such as
hypertrophy o. TIE liver and OF the spleen from
demand the greatest prudence in determining
the dose Of serum that may be introduced into
the veins at c single Injection.
We began our new set. OF experiments on a
young workman who had fallen sick that very
day with all the most serious and most alarm
ing symptoms Of, yellow ,fever-lnternal chill
palms IN the head the spleen. intense pain II
800 centigrade, pulse at 1W. Two Injections
OF twenty cubic ,centlmetres each were made
second subcutaneous. Five minutes after an
energetic general reaction took place. the skin
tho patient eoughed q little. and, 1uiyered ali
over. aud had a chill. Soon after his, tcmpera:
the day athird subcutaneous injection Of serum
was given. The next morning his temperature
%. = a ,.a,n 10 l0p. ftwn KnIFn tnIasfinnR KyATl