New-York tribune. [volume] (New York [N.Y.]) 1866-1924, 1897-04-13
TUESDAY,,
APRIL IS. 1897.
AN IMPROVED TUBERCULIN.
DR. KOCH DESCRIBES HIS NEW LYMPH
LATER EXPERIMENTS ENABLE HIM TO PREVENT
ABscEssEs. AND YET IMMCNIzE coNsuMP-
TIvEs-GRINDrNG THE BAcILLI
Observation-Disclosures

IN MORTAR
Berlin dispatch TO The London News.
Professor Kochs article. in which he gives par
ticuars OF hts improved tubercul!n vii appear
sschrift' edited BY Professor EuIenbars About
disappointment that followed Is within the mem.
hin Himself lose faith IN mis- discovery and FOR avs
years he has been endeayorng to improve ~ Ine
he Me Avoids the word
and confines himself to speaking OF consi .
edy Is no, effective unless used in the early stages
Concerning the difficulties encountered by him in
seeking a lymph which would render the human
subject immune, D,. Koch says that solutions WITH
tered the fluid It had no better effect than his
FIRST tubercun. when. after several years OF ex.
baciili in an unchanged. or. exactly speaking IN
undestroyed state. could not be ABSORBED: IT,
without destroying their characteristic properties;
6one By dssolyns them By ,D, essT,e
which covered each bacillus All the nrst eApe,r
failed only when wel-dried ns su,im ms IN an
agate mortar, withou, any adrnixtu,e one coSc
that the bac deceased ordsr 10 are remove
these DR. Koch diluted the substance nus ,o "o
bv means Of a powerful centrifugal machine which
made four Thousand revolutions IN a nlinJ'e -
hud was IN abont hs an noqs
layer, which contained 70 more ba Gill;, Win
m no ocb JAILED the Upper layer Tu6srcuIine
a5b DR. Il S:iiom Isyst NJ. E r.
ordinary tubercniin in its qualities !, has almost
the Effects as ,he igofTcl saJaysr has d.
cidedIy 'immunzlns effect u csr,aihnIy .,S S'
some reaction u TOO Of hsse reactions
While in using ordinary tuberculin or tnoer eo
an,91in or T. o. TsaGG ben Ting Effects Or Koch
in using r. R. endeavors TO avoid sncn
For IBIS 1C We're ZEE mad made 0y 70 oow Zach
nmckiy as the patients condition allowed TO make
him him Is rs soV render ID him IMMUNE r.
and against the tu5ercle ba;ih themse ess. a..
ma@e as with the uIb,r.uin, the back with 2
syringe The hud CONTAINS IN one sun,c rsd.h 81
Tcramrne is given Ars;. This Is such small do:s
es only very rse s r rsaf' more e7ii diluted ne mice
lions are made abou; every second day, and ths
dose . sseve nf degree is avoided The
rising Of the temperature II caused oy 1872 w n'
s s,un tie AFFECTIONS As n rule DR. Koch ~.
creases the dose mp 10 twenty rlligrammes ana III !.
no AZ nnv after longer pauses He has gained
the impression that complete immunity Is attane1
about two or three weeks AFTER inc "pp"e"'''' -
The preparation has been applied by Or kocS3
iupls and he has achieved without exception an
far sr9a isy tmd9 eas says Dr.
Koch enough many of the cases may De resalaeV
cured in the ordinary sense ems word 20 cure Ssfore
siif;icen, time has assed without relapse Inc
patients felt we'll tiey steadily Increased IN weisns,
End what was especially striking, their temperate
ure did nor show the well-known variations IN coiis
simptive patients The Professor says ne does nTs
venture 70 regard his lymph as the best possible
ia intimates that experiments are Deing iuaue VII"
new serum which may prove still more enlcac'oIs,
bu, no &. ccoyucad that the pre- paraton OF tns
,ubercle cultures cannot be brought to greater per-
fecton. - ,,o Great
danger OF his experiments The cultures useo muss
he az fresh as POSSIBLE and an investigator must
not forget that l. the most virusent ayRs tuves
Gle bsclu which he has to deal with. ana nav tney
sra varied upon In dried state, so that dust can.
no. he avoided II do not" he says, think tns
danger connected with these expsriments 10 oe
and I must confess that often had reehns as IL
we're dealing with explosives 49,. 100000.
eohen,csl fa~.ory at H6chst. which produces
pahr,nos dinhtherta serum Is now selling The new
nj