The San Francisco call., 1896-05-31

large, others smaller and of irregular color.
The periphery of this sphere is even and
sharply defined, making strong contrast be-
tween it and the hyalosphere. AS regards
size this sphere is variable. Frequently it is
very large or it may constitute only narrow
crescent. 1t frequently happens that at one
pole of the corpuscle the granosphere is very
large, while at the other pole again it is small
or even wanting. While the plssmosphere
and probably the hyalosphere extend all round
the nucleus, the granosphere is confined to the
two poles. 1t is this granosphere which evil
IDENTIFY presses on the nucleus at each pole and
causes the dell in the nucleus. BY this do
not mean that it always lies nearest to the
nuclear dell. but simply that it is the outer
most of the spheres which press around the
nucleus at certain points and cause dell or
fattening at this point.
Between the granosphere and the nucleus
there is always a very thin layer OF hyalo-
sphere, but as this sphere extends all around
the nucleus it is evident that 1t cannot be the
one that causes the dell.
The granosphere at times is situated much
further away from the nucleus, and when in
this state it has also a more round form. The
contact with the nucleus then causes the
granosphere to flatten out while it causes a
cavity in the nucleus. The granosphere must,
therefore, be composed of a denser protoplasm
than the nucleus But this greater density
would probably not in the absence of cell
wall be able to impress the nucleus except for
the elasticity and tenacity of the outer layers,
the plasmosphere and the hyalosphere, which
prevent the granosphere from escaping.
CENTRosPHERE.-This is the largest of the
most interior spheres. 1t is nearly always
we'll defined from the granosphere and fire.
quently surrounded by light irregular body.
Its position in the granosphere is variable; 1t
may be situated at the base OF the cone, or it
may form the center of the rounded grano-
sphere. 1t appears TO be the movability, the
| position of the centrosphere, which determines
the form and position OF the sphere. Thus in
all eone-shaped plasmocytoblasts the centric
sphere is always situated close to the base,
| while in the rounded plasmocy ytoblasts the
centrosphere is situated III the center, or
nearer the center OF the granosphere. The Gen.
'trosphere then determines the shape of the
| plasmocytoblast. The form of the centric
/ sphere is variable. 1t is generally round, or al
least rounded, but sometimes it is starlike
| There may be one or more, sometimes three
rarely, for centrospheres in each plasmocyto'
blast In the case of plurality of centro
| spheres there can be little doubt but that they
are parts OF the original centrosphere parts
which have separated and which carry away
each one respectively. part OF the grano
sphere as kind of envelope.
AS regards staining, the centrosphere stains
generally more family than the granosphere
But by some unaecountable reason the rebul
ometimes. occurs. III successful stains with
eosin and thiorin or eosin and methylblue o
the centrosphere is frequently stained pal,
pink.
SoMosPHERE AND CESTRosoMEs.-We nov
come to the innermost of the spheres, which
again contains one or more darker staining
minute bodies. l think there be no doubt a
to the nature of these and that we here have Il
deal with the centrosomes of respective in
vestigators, whether use will distinguish the
somosphere as separate from the centrosome