Wheeling register. [volume] (Wheeling, W. Va.) 1878-1935, 1896-02-07


PIocarpin was added to the solution
for two purposes. First, 10 induce
leucocytosls 90. Second, to stimu-
late glandular activity. Ii also accom-
plishes a third purpose, for it is an
expectorant and a stimu.ant OF secre-
tions Of very considerable power. IL
causes a certain increase in the am
cunt OF water separated from the
blood in the lung cells. This IS shown
by the fact that there is an increase
Of watery vapOr carried off by the
breath Of person taking it.
A SHORT STUDY
Of pilocarpin is interesting. A. Curci
ID states that this drug produces ny
per-secretiOn; in large doses it causes
commissions and paralysis. The par
alysis is is accounted for by regarding
ium compound; hu, phenol and the
Oxlmhydroxy group are more powerful
in producing representation, while at
the same time there is less danger OF
causing commissions and paralysis. 1t
is not improbable that in the organism
change may occur. a pilocaIpinate be-
ing formed the basis Of the body. In
dogs the drug leaves body in the
urine as free pilocarpin, and also as
a pilocarpinate. Pilocarpin has been
used in Group and dip,heria by Sziklia
02) he giving pilocarpin hydTochOride
in doses 0.02 to 0.07 for children, and
0.0S to 0.10 for adults. Leyden mas
used one-half to two per cent. solu-
ton of the simultaneous injection. Rim
ger and Jaunson G8) have administer
ed for experimental purposes O.O325
grains Of nitrate of pilOcarpin. Weber
90 experimental on himself using
c. c. of a half per cent. solution. No
one who has given large dose of ia
borandi or its alkoloid pilOcarpin, and
has observed the enormous amount Of
water that almost fills the lung cells
the small and the larger brOnchi, will
forget the danger that impends from
odema Of the lung. OF course the
amount of pilOcarpin even in the larg-
est doses of Aseptolin, is not sufficient
10 cause q percepdble effect in this
direction.
FRCNd WHAT HAS BEEN SAID
ii will he apparent to all chemists that
The fluid is a hydrophenol containing
q definite amount OF new pilocarpin
compound.
II is not so very difficult to make
provided one has the apparatus and is
sufficiently careful. Il needs extreme
care. The experience Of my laboratory
assistant. as written in q note to me,
is as follows;
For two months I could not pro-
duce n satisfactory fluid more than
once in three times. in fact. 1 think
we threw away during the first three
months about oDehalf or nearly all
of what We made.
"The results o. our experience with
guinea-Digs were such as to convince
any one that TO phenol solution Of the
strength Of the pilocarDin-phenol-hy-
dravide soln ion except the latter
could be safely injected. II other men
make ft hey should he extremely care
fri. otherwise their product may give
rise to serious consequences. At The
same time. there is no reason why a
cCu0otent chemist should not make 1t
successfully"
The solution prepared in my labora-
tory is a cOlorless fluid strongly re-
fracting light, and having the charac-
terist.c odor and taste Of pAenol. In
jected under the skin il causes a sharp,
burning pain, not as severe as that
following an injection Of OF bichlorid
of mercury in solution In the great
majority of cases the injection is not
followed by any local irritation what
ever. In a few. slight nodule ap-
pears ut the point of injection, which
rs a rule disappears in a few days.
Dr. Glover~C. Arnold of New York,
declares this nOdule results from in
iecting fluids against the flow OF the
capillary lymphatics. and advises all
hypodermatic injections to be made
with the needle inserted
IN THE DIRECTION
of the flow Of these Emphatic vessels.
This. in the abdomen, which in my
opinion forms the best site to give
large injections, would be effected by
direction the insertion of the needle
away from the median line. Though
/ have giyen / ,00J injections and some
OF them very large ones, viz, single
injections Of $50 minims each, l have
not seen a single absceSs resulting
therefrom. and nodulation in only two
cases. one of these was on my own
person following an injection of 250
minims for experimental purposes.
No reaction, such as follows the adj
ministration of tuberculin is observed
after the injection Of properly prepared
pilCcarpin-phenOl- nor is
there any visible physiological action
noted following an injection Of 25O
minims given to a man weighing $50
pounds, except that the urine passed
subsequently reacted strongly TO tests
made to ascertain the presence of phe-
mol. and traces Of phenOl were noted
in the condensed vapOr of the breath
and in the contents of the stomach
drawn off through the aesOphageal
tube within three hours of the injec-
ton.
The effect of the solution when in
jected into the organism of patient
suffering from disease caused by ac-
tive germ infection is to directly in
hihit bacterial development and cOnse-
Quently to diminish the production of
a poisonous bacterial products. It's
beneficial effects are so quick and pos
tive in the great majority of cases as
to convince any one who uses it Of the
correctness of this conclusion. This
action. however. is not all phenol and
pilocarpin phenate both stimulate
glendular activity and exert a
PHYSIOLOGICAL EFFECT
in this direction, over the range Of
which they act synergisticallyA 1t
follows. therefore. that the remedy
stimulates the production of the leuc-
ont-Ene