Middlebury register. (Middlebury, Vt.) 1886-1937, 1895-02-15


aud since Roux's serum is presumably
identical with Behring's, what is said Of
the latter applies also to the former.
Behring considers II vial Go C.c.) OF his
serum No. sufficient for "A child under
10 years of age, If seen not later than on
the third day of the disease; advanced
cases require repeated injections of No.
l or equivalent injections of Nos. 2 or 3.
The latter concentration is generally
used for very severe cases, with con-
comitant critical constitutional symp-
toms.
OF Aronson's diphtheria anti-toxne,
one cubic centmeter Is said to be the
dose for adults and older children, one
half cubic centimeter for young chill
dren; in advanced cases the doses are
repeated once or twice at intervals of "a
hours.
About one-tenth of the full dose is said
ures, and about one.fourth serves to
arrest the progress of the disease in its
incubation stage.
Under the influence of the injections,
it is reported, the general condition re-
mains unusually good; the temperature
rapidly declines, often after the first in
lection, in very severe cases of angina
diphtheritica it falls by lysis after % in
jections. The pulse does not return to
normal as quickly as does the tempera
ture. The pseLdo-membranes cease to
spread within the - hours after the first
injection, and they become loOsened after
3G.4S, at the latest, y hours. The com
plications which usually follow the re-
cOvery by ordinary treatment are said to
I rarely occur in cases cured by the anti
toXine treatment.
The degree and duration of protective
power of the anti-diphthertic serum
seem to be as yet not settled definitely.
DIR. kossel thinks that the protection of
healthy persons by incubation does not
extend beyond three weeks.
As for local treatment, it is generally
considered not necessary to employ il
when anti-toXine is used. lnasmuch as
corrosive sublimate destroys the diph-
theritic poison, it may, perchance, de.
stroy the anti-toXIne; and thus the
usually bad results with local treatment
may be accounted for. RouX has uset
equal parts of menthol and pow cree
camphor, which liquefy on mixing. auC
so are easily prepared for application
However, no local applications are eX
cluded save those which interfere will
the action of the anti-toXine, of whicl
, mercuric chloride is the first aud carbol
acid is the second.
a There are chiefly three diphther
a anti-toXines in the market: Behrng' :
! AronsOn's and RouXs. Ut is reporte,
that there is also Listers, from Eng
h land; and in many places in Europe an,
, in America attempts to produce tn
serum are being made.)
! Behring's solution is prepared by til
. Hoechster Fabrik (Meister Lucius !
Bruening), and is supplied, as alread,
, intimated, in three strengths, designated
Nos. |, and 3. \ vial of No. con
tains 10 c. c., which is equal TO 600 anti
toXine "normals;" No. , contains IT,,
equivalent of 1000 anti-toxine normal
No. 3 contains 1900 anti-toXine normals
The solution should be protected fron
= light and stored in Il cool place; will
proper care the solution will keep well
. it is said, for several months.
= RouX's is prepared in the Pasteur in
= stitute of Paris, and was introduced t
the attention of the clinical report b.
the author before the late hygienic con
gress at Buda-Pesth. This product i
presumably Identical with Behring's. |
y, is not yet obtainable here; all the pro
y duet manufactured is apparently reserv
ed for use in France. DR.. Paul GIber
director of the New York Pasteur insli
: tute, has, on "A small scale, prepared tn
- anti-diphtheritic serum according to tn
y formula of DR.. ROuX, but it seems to b.
- very scarce.
: AronsOn's is made by Schering of Der
> lin, and was the first of the three actual
ly supplied in this country. Thi
preparation is of one strength only, an,
- is supplied in two-glamme walls and il
!, live-gramme walls.