davidaulloa/AmericanStories huggingface dataset:
Evening bulletin. [volume] (Honolulu [Oahu, Hawaii]) 1895-1912, 1895-10-23
BULLETIN BICYCLE CONTEST.

The subjoined ballots, renewed
every two days, will be received
at the BULLETIN business office,
600 King street, until II O'Clock
noon on Wednesday, November
27, 1895. Each No. Of ballot will
only be acceptable Up to the time
noted on it, and ballots will be
counted and the results announced
immediately thereafter. More
than one vote for one bicyclist or
one bicycle on a single ballot will
render it void.
Evening bulletin. [volume] (Honolulu [Oahu, Hawaii]) 1895-1912, 1895-10-23

New Advertisement G.
Notice

NO BEGINNERS WILL BE ADMITTED
" TO the Y. Nj. G. A. vocal class ut.ur
Friday evening next, which will be the first
VI the course owing 10 the failure Of the
lights on last Friday evening. Secure your
ticket of irof. Cook before thnt time.
l33it
7 AM NOW prepared TO accept your orders
for dy"ing, an kind, uf cotton goods,
wooicns, silka, crcpcs, lawns, cite, at
cheapest prices:
wINANIOTO.
lg2-u SW Cor. of King and Mnuuahca ST.
Evening bulletin. [volume] (Honolulu [Oahu, Hawaii]) 1895-1912, 1895-10-23
THE PRIZE,

The Most Popular Bicyclist"
according to the ballots cast will
be awarded the prize of the Best
Bicycle" sold in Honolulu accord
ing to the same vote. The follow
ing named gentlemen have kindly
consented to act as tellers and
judges Of the contest
G. M. WHITE,
j. T. STACKER,
E. A. WILLIAMS.
The record-union., 1895-06-12
THE DOCTORS FAILED.
Then jerks Studied Up His Own Dis.
case and Cured Himself.
(from 0te Providence, r. Z, BuLLetin.l

tfron1 the I'roctde7tce, III. L., BuHetfn.)
There are but few diseases that puzzle
physicians more than rheumatism. There
are q great many theories as to its cause,
and great many theories as to the best
means OF curing 1t, most of which are absurd.
One of the greatest sufferers of rheuma-
tism known in the annals of medicine is
John G. jerks, of Riverside, r. /. He
became the victim of rheumatism while
in the army, and the disease seems to
have given him taste of all its various
fortunes. Physiciansand medicinesfailed to
give him any relief, until at last he effected
his own deliverance from the bonds of pain.
''Rheumatisn!' said Mr.. jerks, when the
subject was preached by reporter who
went to hear his story 'sWell, should
say | dc know something about 1t; all
learned by actual experience, too. | first
contracted rheumatism in the army, and I
have had every variety Of the affection
since. and have suffered such agony with it
that at times death was pleasant thought
to dwell upon. Take medicine? Enough
to stock drug store, and none of it did me
any good. Then | began to study the dis
ease myself / made up my mind to get
acquainted with the enemy and fight it on
different lines. | had a theory of my own
and began to look around for remedy that
was calculated TO nave tne ueSIeu eHecI.
One after another was tried until at last
hit upon Pain-Killer, which Iapplied freely.
Almost with the first application came re-
hefSsI kepton using it and the rheumatism
was soon knocked out. Neither have had
any return of the trouble.
II also used Pain-kilier internally for
the ague, another war relic. 1t did what
pounds of quinine couldn't do.
"Pain-Killer keeps guard in my house
against all ills, and it has never yet slept at
It's post of duty
The record-union., 1895-06-12
HORSES TO BE SLAUGHTERED.
The Surplus Stock VIII be Canned ant
SAINT RI

sent 10 Germany
The future of the horse of the Western
ranges is solved. He is to be slaughtered,
canned and then sent to the larger cities
of France and Germany for consumption,
says the New York World. This is a
question that has been troubling the
stock men of the West ever since cleo
tricity, steam and the bicycles have
usurped the usual place of the equine. For
years thousands of horses have ranged
over the Western country consuming food
needed for cattle and sheep. They were
literally not worth their oats. Horsemen
had tried every market in the country for
their surplus stock but no buyers were
to be found.
In Portland. Or, company has been
incorporated to engage in the buying and
slaughtering of horses and the preparing
of their flesh for food, utilizing the oil,
bones hair, ETC., and making fertilizer of
the offal and refuse. The company has
already purchased about 5000 horses and
has options upon as many more. The
Strengthening will begin as soon as the
machinery can be put up. There will be
no scarcity of stock, as it is estimated
that there are fully 100000 horses run
ming wild in Oregon, Washington, Idaho
and Montana.
The horse is pachydermatous or thick
skinned animal. but its skin is not SO
thick as that ofthe OK. 1t clings tightly
to the flesh, and cannot be removed as
the skin of a Illuminating animal, or OK or
sheep can. 1t is as difficult to get Off as
the skin of a hog. The skin makes good
leather of its kind, and the oil is excel
lent for machinery; the long hair of the
tail is woven into haircloth for upholster-
ing chairs and sofa and lining women's
skirts, and the name hair is used for
stuffing chairs and sofas. The bones are
good for many things-buttons, knife
handles, bone-dust and charcoal. In
fact, every part of the animal can be
utilized. The incorporators will en-
deavor to sell tbs horse6esh as food and
to popularize it as suoh on the Pacific
Coast.
The record-union., 1895-06-12
TN THE SUPERIOR COURT OF THE
/ County of Sacramento, State of California.


In the matter of the estate and guardian.
ship of OTTO CHARLES HARRISON, minor
Order to show cause on application of guard
ian for order of sale of real estate.
happening to this court from the petition
this day presented and filed by Lille Harm
son. the guardian of the person and estate OF
Otto Charles Harmson. a minor, praying for
an order OF sale of certain real estate belong.
ing to her said ward, that it was and is bene-
ficial to said minor and to his interest that
such real estate should be sold.
1t is hereby ordered that the next of kin of
the said ward, and all persons interested in the
said estate, appear before this court on FRI
DAY, the 2Sth day of June. 1895, at 10
O'Clock A. NJ at the courtroom of this court,
at the City of Sacramento, In the County OF
Sacramento. then and there to show cause
why an order should not be granted for the
sale of such estate.
And il is further ordered that q copy of this
order be published at least once q week for
three successive weeks before the said day OF
hearing in the SACRAMENTO DAILY RECORD
UNION, newspaper printed and published
in said City and County OF Sacramento.
MATT +. JOHNSON,
Judge of the Superior Court.
Dated May %, 1895.
HoLL IL DUNN. Attorneys for Petitioner.
my29-4tW
The record-union., 1895-06-12
ITEMS FOR THURSDAYS SALE,

Ogoods that have accumulated and marked nothing close
Lots Mems Youths Vests
for &c each. The buttons worth double.
Goats, SO,
Sold when in style for 75c and 81.
Lot Of Mems White Duck Vests sizes SO 55 Slightly
soiled), for 25c.
Here is chance for the boys that Knee Pants We
close lot Of nice styles, well made, in checks and
stripes; material cotton duck. Price, 14c.
Lot Of Mems ST 80 Fancy Percale Shirts slightly
soiled; sizes IL 49,, 5Oc
Mems large size Bathing Suits 25c Sold than
The record-union., 1895-06-12
SUMMER RESORTS.
KLAMATH HOT SPRINGS,
SISKIYOU COUNTY, CAL.
Fifty Miles From Mt. Shasta, Twenty
Miles From Agers California and
Oregon Railroad.

EINEST SPRINGS IN CALIFORNIA.
j. The natural advantages are numerous.
sulphur and mud baths. Eminent physicians
recommend these waters and baths for rheu-
matism, dyspepsia, stomach troubles, and all
blood and skin diseases; good hunting
and fine trout fishing; mountain scenery
grand: delightful climate: commodious stone
hotel. with all modern conveniences; Post
Office, Express and Telephone connecting
with Western Union Telegraph Company.
Table and service frst-elass. Daily stage to
Ager over fine road and no dust. Terms
reasonable, No efforts spared to make guests
comfortable. For further particulars adj
dress EPSON BROS, Beswick, Slskiyou
County. California.
The record-union., 1895-06-12
DefueliZing Wood.

There is point to the story told by Sem
ator Palmer of q farmer who has been
selling him wood for So a cord. This
year." says Senator Palmer, "he came to
me with load and l told him l did not
want it. He offered it at 81 cord. l still
refused and he wanted to know why.
told him 1 was using soft coal for which l
paid 81 81 ton. Gossip he exclaimed,
Il heard you was trying to demonetize
silver ard now you are trying to defuel-
iva wood' ~
The record-union., 1895-06-12
STYLISH MILLINERY FOR JUNE And JULY.

Ladies' White Lace Hat with neapolitan edge
trimmed with tips, silk ribbon, wheat finished
rhinestone and dagger ornaments hand
worth $12, for So 30.
Ladies Black jet edge jet
gilt bell finished
bunch OF jacquenont worth S14 for So g.
Newest style, The Bell Hat, RIM
bell shape, French chip crown, untrnnaed, 81 75
New summer shapes White Leghorn high
wide fancy edges;
The record-union., 1895-06-12
Sacramento Womeni

Feeble, ailing women are made well and
strong oy that great modern nerve in
yigorator and blood purifier Paineis Celery
oon1i ouna. Weak. snaky. tired nerves.
50 much as this food for the. nerves. TRY
it and be well. -
The record-union., 1895-06-12

Following are the reports received by
j. A. Barwick, Director Of the State
Weather Service. for the week ending
Monday night last. These reports are
from all the grain and fruit-growing sec
tions of the State:
The record-union., 1895-06-12

BOARD AND ROOM, 81 90 TO SO PER
ID day. Meals, 20 cents.
The record-union., 1895-06-12

SUNDAY excepted. aMonday excepted.
A-For morning. P-For afternoon.
RICHARD GRAY, Gen. Traffic Manager.
T. b. GOODMAN, Gen. Passenger Agent.
The record-union., 1895-06-12
BUSINESS CARDS

n. +. ROOT. ALEX. NELSON, ]. DRIsCoL.
DOOT, NELSON & CO.,
LIZ Union Foundry-Iron and Brass Found
ers and Machinists. Front street, between N
and o. Castings and Machinery of every de-
cYiption made to order.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04

cs min water, cs lamp chimneys,2 cs dry goods,
plate SO NJ IT lumber. IL bdls pelts, II pkgs ndse,
keg % bxs butter, doors, $50 head cattle, 10 cs
guns, etc.
COnsfgnees.
Per Eureka-Bavaria Brewery: Dalton Bros;
De Bernardo 81 Co; J III Newbauer & Co; H Dutard !;
Chas Montgomery 6 Co. Brigham, Hoppe & Co: J
P Thomas: MARSHALL, Teggart Il Co; S Harvey
Dairymen's Union l. d 81 zone & Co: American Bis
cult CO.. Sinsherner Bros: Wheaton, Breon & Co;
G Whitney d Co: T Stevens IL Co: Fairbanks,
Morse & Co; w B Sumner & Co: Wetmore Bros (;
Milling Co: Porter. Slessinger & Co.. Pioneer
Fish Co; Tillmann d Bendel Cox Seed & Plant Co;
Fl n Tilden & Co; Norton. Teller & Co; VIM Kline;
Camilloni 81 Co: Dodge, Sweeney d Co; Pacific
Tanning Co: Wieland Brewing Co; l. Scatena & Co;
E ] Bowen IL Co; w Fuller & Co: Brays Sons 81
San Francisco Fish Co; L G Sresovich & Co; Chit
cago Brewery; B Haight; Buffalo Brewery; An
glo-Amer Crockery CO.. Witzei q Baker; c ) Har-
ney w G Price & Co: Iyancovich d. Co; l. Gid
macher: Blumenthal & Co; J Friedlander & co;
Hills Bros; l. ID Stone & Co; Hearie d Fraser;
Gusmani; Levi Spiegel & Co; Hooker d Co.
Per Pomona-A Paladini Dodge sweeney q Co;
American UnonFish Co; Nathan Dohrmann & Co;
Amer Press Assn; A Paladini Dairymens u mon
Russ, Sanders & Co; Wells, Fargo u Co; Humboldt
Min Water Co: L ID Stone IL Co; Brown d Adams
Standard Oil Co; WHEEL 81 Baker: Getz Bros d co;
E Whitney & Co; A Croker 81 Bros; w LET
lar: Brigham, Hoppe & Co: Hills Bros; Chas Mel
son: Shrek x Co; Hooker q Co: City street I'M
4 Co. Murphy, Grant d Co; f A La Grange; Royal
Eagle Dist Co: e L L Allen: r Hanify.
For Late Shipping Lltetltoencs See Tenth Page.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
CHICAGO MARKETS.

CHICAGO, ILL, Aug. 3.-Wheat opened easy
to-day, then advanced about ! cent, but as sud
denly changed front and broke back to the starting
point after which the declining inclination con-
tinued and prices exhibited the need they had of
support. The Modern Miller published the est-
mate of the Kansas MilIers' Association. which
was known week ago. placing the crop Of that
State at less than 100000 bushels and stating
that not over 100000 bushels would be fit for
milling It was on this report that prices were ad-
vanced after the opening, but when it was dis
covered that the same news had been acted on
several days ago the enthusiasm oozed out OF the
market and the drop mentioned followed
AS tn session progressed the sentiment became
weaker and holders were actively competing with
gshort'' sellers endeav0ring 10 dispose OF their
wheat Receipts at Chicago were 70 cars and the
Northwest had 50 cars. Export clearances from
both coasts for the week amounted 10 1900
bushels This a holiday in England There
therefore no caoles IRON that country WIN.
drawas from store were 15,459 bushels, and At
laAtfc shipments amounted to 1l5tb6l bushels.
Closing continental cables were higher September
wheat opened at from $3.50 TO 6s1sc, sold between
6914c and 67j2c, closing at 677sg68c, 5Sc under
yesterday. Estimated receipts Tor Monday Ioo
cars.
receipts we're good at 400 cars. This, with the I'M
stable tone of the Wheat market combined TO de-
stroy faith IN better prices. The further decline
today gave added encouragement TO 'shorts," ana
Unless something ato Their unforeseen.akes place
Inc fears Of manpuls& on IN September are erna-
htsit!y set at rest. There were no cables " TN
draw ais from store were IS JOG bushels and 2S9-
Sorn opened at 42c sold between 4Z3sc and Al 18c,
Gl9slng at 4l5st04l$4c, l@l1sc under yesterday.
ESTIMATED receipts for Monday 800 cars.
OatS We're quietly moving along with the TIDE OF
eecllnlug wheat and values There was no
trade nor sensational action. Receipts were 1876
cars 5 y oats were taken from store, September
closed 12c under yesterday. Estimated receipts
Tor Monday 255 cars.
Fls1 was easy. Cash, new, Southwestern, 81 IL;
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
RECEIPTS OF PRODUCE.
THE STOCK MARKET.

Stocks closed the week much frmer. the advance
being as high 15c in several of the leaders Con.
CAL & Va. sold up to 50 &c. Ophir to 81 40, Nor
cross to 81 65 and Best & Belcher to 92c Very
little stock changed hands, however, despite the
rise. The advance largely due to an improve
nent in the Con. Cal. & Va which appears below.
NOTES.
Mining assessments delinquent In the boards this
week will be the Utah Con. OF &c share on
Thursday and the Potosi of Csc share on Satur-
day.
elected the old management.
Superintendent Lyman OF the Con. Cal. & Va.
telegraphed as follows yesterday: output from
floors, So TONS Average car assay, SAG S6 a ton.
From 1850 level from seventh and eighth floors
extracted Sc tons OF ore, assaying SAT 40 ton"
The Pacific Lighting Company has declared a
dividend OF 80 cents, payable on the 9Th.
The Central Gas Light Company will pay the
usual quarterly divide1d of 81 this month.
The California Cotton Mills will pay the usual
quarterly dividend of 81 this month
The Spring Valley Water Company will pay a
monthly dividend of so cents on the 10th.
The Pacific Gas Improvement Company will pay
a dividend of so cents on the 10TH
The Pacific Auxiliary Fire Alarm Company has
declared dividend of cents, payable on the 10TH
started from the north lateral drift 1O6 feet north
of the station is advanced 81 feet face is in por-
station is advanced IS feet; face is in porphyry
with stringers of quartz In the south drift from
the west crosscut from the face of the north drift
fourth floor of north uprase they extracting
some fair-grade ore. The east crosscut from the
fthird floor Of the old slopes is advanced 20
eet this drift continues to pass through punches
from the face Of the main south drift they continue
to stope very good ore. During the week they have
hOised 38 cars OF ore; car samples average sos 70
per ton.
Following are the Highest Prices Durin z
the Past Week.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
WEATHER BUREAU REPORT.

UNITED STATES DEPARTMENT OF AGRIcuIr
TURF. WEATHER BUREAU, SAN Francisco.
August 8, 1895, P. n. -Synopsis and general
forecast.
The following are the seasonal rainfals to date as
compared with those of the same date last wear:
Eureka IL, last year 90: Red Bluff Is, last
year 90; Sacramento Ca last year trace; San
year trace; san Luis Obspo 90, last year rec
ord; Los Angeles 90, last year trace; San Diego
90, last year trace: Yuma OF. last year SO.
Inc Following maximum temperatures are re-
ported from California stations for to-day: Eureka
6O deg san Francisco 6S. Los Angeles 7S, Red
Blum 1O4, San LUIS Obispo SO, San Diego TO- Sacra-
mento IS, independence 81, Fresno 104, Yuma
San Francisco data: Maximum temp erature 40
deg, minimum 81 deg, mean 81 deg.
An area OF unusual high pressure for this season
OF the year is now central of the Washington
coast while the pressure is lowest in Arizona and
IN Montana. These are the conditions which pre-
cee the hot northers in the interior of California
owing TO the fact that unusually high temperatures
valleys Exceeding 100 degrees in many places) it
is not anticipated that any marked change will
take place in those sections before Monday, but
the temperature VIII probably rise thereafter until
Wednesday Thursday, when the temperatIlre
VIII probably equal exceed that of any previous
date this season.
Forecast made at San Francisco for thirty hours
ending midnight August 4, 1895:
For Northern California-Fair in the interior.
cloudy anu foggy along the coast; continued high
temperature, with north wind in the Sacramento
uesn westerly winds along the coast.
For southern California-Fair; stationary tenn
perature; fresh westerly winds,
For \ evada-Fair; stationary temperature
FOR Utah-Fair; stationary temperature
FOR AriZoua-Fair: stationary temperature
For san Francisco and vicinity = Foggy and
cloudy at night: fair during the day; stationary
temperature; brisk to high westerly winds in the
afternoon w. h HAMAoS, Forecast Official.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
WHEAT AND OTHER GRAINS.

WHEAT-Futures declined again and spot grain
was easy. No. l, CSC; choice, 971a@9S34c q ctl;
lower grades, S5@e21ac; extra choice for milling,
81 Q ctl
CALL BOARD SALES.
IrSFoRMAL SEssIoN-10 o'clock - December
HOO tons, 81 033s; 100, 81 OS14. May-11Oo,
81 1914. ,
tons. 81 OBS; 100, 81 G3; 800, 81 O3A. May
200, 81 10: 100, 81 1914. Seller 'o5, new storage
paid-lOO, 81 O0s4 100 81 0012.
BARLEY-No change at all, either in spot or
future prices No. Feed, 60@6114c: choice, 6212c:
Brewing, 671a@75c p ctl; Chevalier, 81 10@1 Is
for No. and 60@75c for of grade.
CALL BOARD SALES.
INFORMAL SEssIoN-10 mber-200
tons, csc: 800, $3.50; 100, SAGE; 200, $3.50
Seller '95, new-500 60c.
REGULAR MORNING ACKNOWLEDGEMENTS
tons, 64Ssc.
OATS-Quet and unchanged. Milling, Sl@l 05;
fancy Feed, $1@1 O5; good to choice, S71a@95c;
common to fair 75@S5c; Gray, S212@S5c: Red,
75@SOc; Surprise, 971sc9$1 0712 p ct
CORN-Not much going on. Large Yellow 81 IL "a
al 171a p ctl: Small Round elbow, 81 1891 20;
White, S1@1 10 q ctl
RYE-Quoted at 75@SOc . cti for new
BUCKWHEAT-85f@90c p ctl.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
Word.

old; Northwestern, 81 Is, nominal: August
81 0812@l %; September. 81 071s@1l %: October,
81 O742; November, 81 0S1a. Receipts were 30
cars.
Provisions-The business of the entire session in
product might have been transacted in fifteen
minutes without crowding. few people con-
rise in values, and when some unTary "long"
tried TO sell a little ne found prices lower. The
grain. September pork closed 21ac lower; Sep
higher.
Wheat-August, &c; September, CSC; Decem-
per, 7014c.
eCorn-A ugust,. .416sc; September, 4lssc; De-
cember, 3414c; May, 34s4c.
0ats-August, 2lc; September, 2114c; May,
Pork.oseptember. SO s21a; October, SO 70; jan
uary, SO 7212.
Lard Lard-Aug5st, Sc 1917; September, Sc l714;
Ribs-september, SIS s21a; October, SIS s71a;
January, IS 4212.
There was arAactive demand for fancy makes of
outter, and prices for them were firm, Medium
ana lower grades were not in such request and an
easier feeling was noted in them. Quotations were
unaltered.
Eggs were quiet and steady. Offerings were
moderate, while the demand was light and alto
gether local. Fresh stock sold at lie per dozen.
Livestock.
UNION SToCKYARDS. ILL, Aug. 3.-The
usual light arrivals for Saturday in evidence
10 cattle to-day. The market was dull and steady,
Extremely small receipts Of hogs caused firmness
anu oC auNauCS IN JuaG market. Inc demand WAS
not extraordinarily heavy. The few sheep and
lambs coming in to-day were easily disposed Of at
full prices.
Cattle = Receipts, 500: common to extra
steers, 50 6006 90; stockers and feeders, 81 100
4 10: cows and bulls. 81 65@3 10; calves, $50
90; Texans, So 25@4 90; Western Rangers,
Hogs = Receipts, 1000: heavy packing and
mixed, 81 60@5 choice assorted, s5@5 20; light,
81 70@5 %: pigs. So 25@4 so.
Sheep - Receipts, 1900; inferior TO choice,
$2(94; lambs, $S(94 80.
The San Francisco call. [volume] (San Francisco [Calif.]) 1895-1913, 1895-08-04
OCEANIC STEAMSHIP COMPANY.
PACIFIC COAST STEAMSHIP COMPANY

CLEANERS WILL SAIL FROM .Afsa.
- Broadway wharf, San Francisco, EasstssZ
follows:
For Mary Island, Loring, Wrange. juneau, Kill
lisono and Sitka "a laska), at, A. M August 3, g.
Is. September 2, II.
For Victoria and Vancouver (B. C.), Seattle
Tacoma, Everett, Anacortes and New Whatcom
(Bellingham Bay, Wash.), A. NJ August 8, 8, Is,
lS. 80 %. and every fifth day thereafter, connect
ing at Vancouver with the G, T. r. r.. at Tacoma
with n. P r. r., at Seattle with G. N Ry, at Port
Townsend with Alaska steamers.
For Eureka, Arcata and Fie DIS Landing (Hum-
boldt Bay, str. Pomona, every Tuesday at P. M,
For santa Cruz, Monterey, San Simeon, Cayucos,
Port Hartford (San Luis Obispo), Gaviota, Santa
Barbara, Ventura, Hueneme, san Pedro, East san
Pedro clos Angeles) and Newport, A. NJ, Aug ust
l, 8, 49, II, 81, %, 20, and every fourth day
thereafter.
For San Diego, stopping only at Port Hartford
(San Luis Obispo), Santa Barbara, Port Los
Angeles, Redondo (Los Angeles) and Newport, IL
M, August 3. Z, II, Is, 10, 49, ~, 81 and every
fourth day thereafter.
Str Pomona Saturday and Monday, excursion
to Santa Cruz and Monterey, leaves Broadway
wharf 1, Saturday, 4 P
For Ensenada, San Jose del Cabo. Mazatlan, La
Paz, Altata and Guaymas (Mexico), str. William
cite Valley 10 A. NJ. 25th of each month.
Ticket Office, Palace Hotel, 4 New Montgomery
street.
GOODALL, PERKINS d. CO., GenT Agents.
10 Market St., San Francisco.