The McCook tribune. (McCook, Neb.) 1886-1936, 1894-03-23
MoRPHlNE,s NEW ANTIDoIE.


Dr.. Moor Tells How He Made the Diseov-
cry and Of His Experiments.
DR.. William Moor, whose discovery
of permaDganate of potassium as an n
tidote for morphine poisoning has made
him famouA has written a paper upon
the subject which has been published in
a we'll know i medical periodical. In
this he treats the subject almost al
together. as might be expected, in a
technical manner He tells, however,
of the Investigations that led to his dis
covery in the following words:
After some trials found that the
best way Of administering it was to
have it made up in pills with cacao
butter and talcum Of kaolin, and to d.
rect the patient to drink very slowly a
glassful of water just one minute after
taking the pill, for the latter begins to
disintegrate in n minute at the tenn
p~erature Of the body. By using this
method successfully combated the ex-
tremely disagreeable odor in a case of
cancer of the stomach.
About that time / treated a well
known actor suffering from acute pleu-
rlsy. This gentleman was addicted to
morphine, and as l had taken much in
terest in him l earnestly sought the best
plan to break his habit. The idea oc-
CURED to me that perhaps permanga-
nate OF potash might decompose NOR
phine, the latter being an organic sub
stance, and that by making use of a
certain method | could eventually break
his habit without restricting him from
taking his morphine. My patient, how
ever, started on a professional tour just
when began to put my idea to a test.
This circumstance did not prevent me
from continuing my researches as to
the effect of permanganate of potassium
on morphine, and today am permitted
to offer to the profession what 1 consider
to be the antidote par excellence for
morphine"
Then considering in detail the pecul-
lar effects of the antidote when differ
emily administered DR.. Moor continues:
Having gained the knowledge of
these facts, it is not surprising that l
could swallow with impunity toxic
doses of sulphate of morphine followed
in a few moments by a corresponding
amount Of the chemical body which
l was justified to consider the antidote
par excellence for morphine. Thus on
n occasion four hours after a full din
ner, at a time when the stomach must
have contained a great amount of solu-
BILE peptones and other organic matter,
l took two grains of the sulphate of
morphine in about half of an ounce of
water, followed in one minute by three
grains of its antidote-for safety's sake
one grain more than necessary-dis-
solved in four ounces of water. In an
other instance three hours after a light
supper I took in the presence of several
colleagues belonging to the staff of the
West Side German clinic of this city
three grains of the sulphate of NOR
phine, followed in about 80 seconds by
four grains Of permanganate of potas-
SUM, both in aqueous solution. / was
perfectly confident that the antidote pos
sessed such a wonderful infinity for the
morphine that it would select it instan-
taneously from among the contents of
the stomach.
In case Of poisoning by any of the
salts of mcrphia 10 to Is grains of the
antidote dissolved in six or eight ounces
of water should be administered at once
and repeated at intervals of 80 minutes
three or four times, or even more often.
Permanganate of potassium as well as
the salts of manganese are compare
lively harmless, even if given in large
quantities"
DR.. Moor continues: sin cases of
poisoning by the alkaloid itself or by
tinctnre Of opium Q~audanum), also by
opium, it is advisable to acidulate the
antidotal solution with diluted sui
phuric acid, or in the absence Of this
with some white vinegar-not red vine
gar-by which the insoluble morphia
will be at once converted into the solu-
BILE sulphate of acetate. I have strong
reason to believe that the administra-
ton Of permanganate will be of bene-
fetal effect ven after absorption Of the
morphine has taken place"