Reporter and farmer. [volume] (Webster, Day County, Dakota [S.D.]) 188?-1946, 1894-11-29
MoRPhiNe'S NEW ANTiDoTE.
DR.. Moor Tells How He Made the Discovs
cry and Of His Experiments.

Dr.. Moor Tells How He Made the Discov.
cry and Of His Experiments.
DR.. William Moor, whose discovery
Of permanganate of potassium as an an
tidote for morphine poisoning has made
him famous, has written a paper upon
the subject which has been published in
a we'll known medical periodical. In
this he treats the subject almost al
together, as might be expected, in a
technical n He tells, however,
of the Investigations that led to his dis
covery in the following words:
AFTER some trials I found that the
best way of administering it was to
have it made up in pills with cacao
butter and talcum of kaolin, and to d.
rect the patient to drink very slowly a
glassful of water just n minute after
taking the pill, for the latter begins to
d~isintegrate in one minute at the tenn
perature of the body. By using this
method l successfully combated the ex-
tremely disagreeable odor in a case Of
cancer of the stomach.
About that time / treated a well
known actor suffering from acute pleu-
risy. This gentleman was addicted to
morphine, and as | had taken much in
terest in him | earnestly sought the best
plan to break his habit. The idea &C.
CURED to me that perhaps permanga-
nate of potash might decompose NOR
phine, the latter being an organic sub
stance, and that by making use of a
certain method | could eventually break
his habit without restricting him from
taking his morphine. Ny patient, how
ever, started on a professional tour Just
when | began to put my idea to a test.
This circumstance did not prevent me
from continuing my researches as to
the effect of permanganate of potassium
on morphine, and today l am permitted
to offer to the profession what | consider
to be the antidote par excellence for
morphine"
Then considering In detail the pecul-
lar effects Of the antidote when differ
emily administered Dr.. Moor continues:
Having gained the knowledge of
these facts, it is not surprising that /
could swallow with impunity toxic
doses of sulphate of morphine followed
In a few moments by a corresponding
amount of the chemical body which
l was justified to consider the antidote
par excellence for morphine. Thus on
one occasion four hours after a full din
ner, at a time when the stomach must
have contained a great amount of solu-
bic peptones and other organic matter,
| took two grains Of the sulphate Of
morphine in about half of an ounce Of
water, followed in n minute by three
grains of its antidUte-for safety's sake
u grain more than necessary-dis-
solved In -four oances of water. In an
other instance three hours after a light
supper | took in the presence of several
colleagues belonging to the staff of the
West Side German clinic of this city
three grains of the sulphate of NOR
phine, followed in about 80 seconds by
four grains of permanganate of potas-
SUM, both in aqueous solution. | was
perfectly confident that the antidote pos
sessed such a wonderful infinity for the
AAi tbus ~ Oui SCltCL IL IISLdU-
~taneously from among the contents Of
the stomach.
I'm case of poisoning by any of the
salts OF mcrphia 10 to Is grains of the
antidote dissolved in six or eight ounces
OF water should be administered at once
and repeated at intervals of 80 minutes
three or four times, or ever more often.
Permanganate of potassium as we'll as
the salts of manganese are compare
lively harmless, ven if given in large
quantities."
DR.. Moor continues: ''In cases of
poisoning by the alkaloid itself or by
tincture Of opium Qaudanum), also by
opium, it is advisable to acidulate the
antidotal soiu1on with diluted sui
phuric acid, or in the absence of this
with some white vinegar-not red vine-
gar-by which the insoluble morphia
will be at once converted into the solu-
bic %sulphate of acetate. I have strong
reason to believe that the administra.
ton OF permanganate will be of hene.
nciai effect even after absorption of the
morphine has taken placeo