Evening star. [volume] (Washington, D.C.) 1854-1972, 1891-03-14

| longer in making its appearance. does no
| reach as high q point, and subsidies NOR,
promptly than it did after the first and second
| injections. There is also q notable diminutior
of the critical sweats which formerly marked
its defervescence. During the continuance o.
| the fever the severity Of the cough and the
quantity Of the expectoration are markedly in
creased, and equally well marked is the di
intuition Of both cough and expectoration il
the intervals Of treatment, which is giver
every fourth day.
Physical examination shows no change as re-
CARDS the areas of dizziness first mapped out and
very slight and unimportant changes rs to res
piratory sounds.
Examination Of the sputa, twice repeated
shows practically no change in the number OF
morphology of the tubercle bacilli
The patients, with the exception Of case No. 8
all report themselves as feeling better. with i'm
proved appetites, better rest at night, and di.
minished night sweets.
A tabular statement Of weights showed that
six Of ten patients had lost flesh, and that -four
had gained. The total loss was 9 Kilograms,
and the total gain z, 136.
STILL SOME REACTION
In his next report dated February IS, he
said:
The dose has not as yet, in any case been
carried beyond the limit of .0O6 gram which
had been reached at the date Of the last report.
With this dose there is still some reaction
which this amount was administered on Feb
ruary 16 the temperature only reached SO de-
grees after period of six hours
On February 10 a case of lupus was subjected
to an initial injection of .001 gram. The case
is an interesting one from the fact that the dis
ease has existed for seventeen years and has
been subjected to a variety of treatment prior
to this. Up to this time he has received two
injections, and q maximum dose Of .002 gram.
At present it can only be stated that under
no nrodp ant fvr1I ~
action" of moderate severity, that the ulcer is
today partially scabbed over, and that in one
angle there has been growth of new and ap-
parently healthy skin.
death of Morgan and gave the facts of the au-
topsy, which were reproduced in TIE STAR
some days ago.
NO DEFINITE CHANGE.
On the 25th Of February he gave another
table Of weights, which showed that of ten
patients five hadlost flesh, two had remained
stationary and two had gained. Tho total loss
was 1875 kilos and the total gain nine-tenths Of
kilo. In regard to the progress of the cases
he said.
As to the cases Of pulmonary and laryngeal
tuberculosis under treatment, it can only be
said that yet there is no definite change in
their condition for better or worse. Under
doses Of .006 gram of the lymph. repeated on
three occasions, two patients showed no febriie
reaction and complained of no discomfort. An
increase to .007 gram produced in both of them
reaction" reaching ss.5 degrees c., and &C.
companied by more pain and general malaise
than has ever before been produced.
microscopical examination of the sputum.
on February 70 and "a. showed an absence of
Nos. Z, 8 and IL they were diminished some
what in number.
In none of the cases is there any important
change in the physical signs. In case No. IL
(tubercle of larynx) the huskiness of voice has
markedly disappeared, the patient has gained
minished.
THE CASE OF LUPUS
The case Of lupus brought forth the follow
ing remarks:
The case Of lupus, mention of which was
made in the last abstract. has been subjected to
four injections, the maximum dose attained
being COB gram. 1t can now be said that the
disease is apparently yielding to the remedy.
Probably one-fifth of the liberated surface has
cicatrized, and the remainder presents healthy
graduating appearance.
GOING ALONG SMOOTHLY.
The report of March 4 recited that the cases
were going along smoothly. DIR. Geddings said:
Since my last communication the case of
lupus has received three injections. the last two
being, respectively, Of .004 and .005 gram. 1t
was very nOtlceaDle WIN tneSo injections that
while the general reaction was not well
marked (3S degrees to 3S.4 degrees c. the local
symptoms were very apparent. In both in
stances there was increased redness of the dis
eased area, the surface was glistening and the
tissues flushed. tense and with a
pulsating feeling. Today at least one-half of
the ulcer has skinned over, the remainder is
graduating in perfectly healthy manner.
As to other patients, there is no definite
change OF condition to be reported during the
past week. In two cases injected yesterday with
.007 gram the reaction" only reached 37.5 de-
grees c., and in both the cough had almost en-
tirely abated. night sweats have ceased and the
general condition seems improved. In these
cases the sputum remains free from bacilli.
THE LAST OFFICIAL REPORT.
DIR. Geddings last report, dated March 10, is as
follows: 'In the case of lupus injections of six
and seven milligrams have failed on three oc-
casions to produce any general reaction beyond
37.5 c. A slight feeling of malaise moderate
frontal headache and a depression Of the pulse
to 60 per minute have been noted. The local
however, have been very
marked. There have been manifested on each
of these occasions, in periods of time ranging
from eight to twelve hours decided
hyperamia of the diseas ed area and
the surrounding tissues sense of
throbbing and burning. ir -eased emulation
and the formation of vescicles upon the sur
face of the ulcer and the appearance upon the
cheeks OF well-marked erythematous eruption
persists for twenty-four to thirty hours, and is
in some places succeeded by q branny disqu-
nation. Granulation and cicatrizatiOn are pro-
crossing steadily. though more slowly than at
first, and the patient shows a gain in weight of
LAY klos over his previous weight. In cases
Nos. and there has been q marked improve
ment in the past two weeks. In both there is
to be noted continued absence of turbercle
bacilh in the sputum, cessation of night
sweats, expectoration very scanty, no cough,
slight increase of weight in case No. /. and In
both diminutiOn in the areas of dullnesB first
mapped out, decrease of the bronchial and in
crease of the vascular breathing sounds.
I'm case No. the laryngeal symptoms, after
showing decided improvement, have returned
with increased severity. In case No. 5 the
general condition is much worse than at last
report. There are now profuse night sweats,
severe hectic and increasing debility and pros
tration. Case No. 8 has left the hospital at his
own instance in about the same condition as
upon admission, certainly with no marked
change for better or worse. In case No. II the
laryngeal symptoms have assumed great de-
gree of severity, the patient has rapidly lost
weight and the treatment has been temporarily
suspended"
The table Of weights sh ows that since the
last statement of weights four of ten patients
have lost weight and six have gained. The
total loss has been 7.7GS klos and the total gain
11.S27 There have been III injections the
maximum dose being seven milligrams. In
case number eight there has been gain of
4.OS6 kilos, or about nine pounds in a fortnight.
CARE TAKEN IN THE EXPERIMENTS.
Whatever may be the final results Of the ex-