Richmond dispatch. [volume] (Richmond, Va.) 1884-1903, 1891-01-16
PROF. KOCH'S SECRET
-ue COMPOSITION OF TIE GREAT
~" LYMPH MADE KNOWN.
..,,t,tlor Of His Discovcry--How lie
Came 20 work ont tho Problem-
The Remedy Explained.
,..,,,,o-Am,rican caplo to thc Dlspatcb,i

-, January IS The loag-talkod-of
..,f ,bc ingredients entering into the
.,,.,,.on Of Professor Koch's famous
- 3. c.von TO-DAY 10 the world at large:
-. .s..sor Koch saws: Since publishing
.-.,tbs ago the results of my expert
-. o,.th the new remedy for tubercuio-
- musicians who received the pre-
80, have been unable 20 become ac-
.',.e8 With i's properties through their
.,pcrimeu,s So far as have been
M o.. review the statements pabnshed
4 "a che rrmmuulCatlons reCelFeu py lettcI
i t"' 5.rs.,ous have been fully and com
/ o. ..-.' INF rnei The general consensus
4 ,,.r Is tEst the remedy has specific
r.run tubcrcular tissues, and IL,
1v' 4upi,ablc as n veTy delicate and
,..rrnt FOR discovering latent and
Il .,s,r- aouh' ,ul tuberculosis processes.
a CrRE EErAEtIsBED.
.r.-..lirr The curntive effects OF the
rrl,t reports agree that, despite
4 ..rr-ra:iycy short duration Of the
....- many Patients have shown
A'i-.-l l.-a pronounced improvement. IL
.. .hfTed that in not few cases
B i"' ..,va lae been established. Stand
81 ,'.'..'.,,. los itself Is the assertion that the
4 -- mas not only be dangerous IN cases
Il ..,.t sgr advanced too ior-a fact winch
n ,.r forthwith bc conceded nut also that
..r,g, promoted the tuberculous pro-
h l-rc therefore injurious.
o.i,...r. tho past ak weeks / myself
-'t,I oupurtgHity 20 bring together
4 ,'....r .,rtrrcuces touching the curative
80. and diaguostic application of the
4 ,-...5- ,, She cases ~ about one hundred
4 ..f.t.y sufferers from tuberculosis of the
,r.-i.d types iu this city and in the
~. .t,.. Hospital / can Only say that
,....g,rr ! haye latterly seen accords
.i ,ry prey.ous observation. There has
.rr.'ting 20 modify in what / before
B SlrrLUss To KNOW.
go l.rr rs 10 was only a question OF
,....r,f.a % uracy of my indications, 1t
.,.'lI ..s any one % know what the
,.,..Ig contained or whence It was de-
..r.I Or fle contrary, the subsequent
testing would necessarily ne more IN
..s.jtrr ..-- people knew of the remedy
1,.r Nov after sufficient confrmatory
....rr and the importance of the
,.r.5v i, proved, my next task
n, extend my study Of the remedy
i.-.u1 the field where II has hitherto been
,.rlte' and 4 pusBblc 10 apply the princi-
II underlying the discovery to other
4 s...,. jhstask naturally demands a
4 ,r knowledge Of the remedy. ! therefore
.,r.i..er TIM, the time has arrived when
i ,..p.. no indications III this direction shall
D. mode
SOLUBLE SUBSTANCE.
This is doneas follows: Koch describes
.- detail the method 10y which he arrived
p, his discovery IN his experiments with
grir,a PIGS. bringing him 20 the result
,r.s. l.I n h4n
,r, effect IN the tubcrculous process must
h. soluble substance which would
O.. lNyIatcd 60 certain extent
rtln fluid, If the body floating around
,lotuh.rcle bacilh and be transferred in
sar., mpil manner TO the Juices of the
l.4r. while the substance producing sup
rurltl.n apparently remains behind IN
He tubercular bacilli or dissolves, but
very slowly. The only important point
va- therefore TO induce into the outside
body the process going on the inside II
possible and 10 extract from the tubercu-
IN tIGllI alone the curative substances.
AN EFFECTIVE SUBSTANCE.
This demanded time and toll, until |
f-.Ily succeeded with the aid Of 40 to 80
asrc,nt. solution of glycerinein obtaining
Az elective substance from the tuberculGr
arM With the fluid 80 obtained ! made
lu human beings These fluids were given
90 other physicians TO enable them TO re-
l.st the experiments. The remedy which
isus,d IN the new treatment consists OF
r'yceruc extract, derived from the pure
cultivation Of tubercle bacilli.
TIE REMEDY DESCRIBED.
Into tho simple extract there naturally
passes from the tuberculaT haciih, besides
ID. effective substance, all the other mat
'sr soluble IN so per cent. glycerine. Con.
.lueutlylt u contains a certain quantity of
mineral salts. Coloring substances, and
.taer unknown eXtractiye matter. Some
q these substances can be removed from
% tolerahlv "aslly. The effective sub
stance L. iusUluble in absolute alcohol.
i eau be p7eciuitated 10y It, though not,
indeed. IN q pure condition, but still
combined with the other eXtractive matter
paen is likewise insoluble in alcohol.
The col0riug matter may also be removed,
rendering ~ possible TO obtain from the
extract c0lorlcss, dry substance contain
.l. the effective principle in much more
o.rrtntrltrd form than the original glyce
mo solutions For application IN practice
IBIS yuuhcaton # the Clycerine extract
Cdc-, uo advantage, because the sub
stances go eliminated are unesSentlal for
-" human organism. The procost of
rlrt.Atlnu would make the cost OF the
remedy unnecessarily high.
rE1ruETIoNs oY THE SUBSTANCE.
Regarding the constitution Of the more
elective substances, only surmlscs may Tor
'Le present be expressed. il appears TO
ut 90 be teryutye from albumlnOus
bodies, having close affinity TO them. IL
does lo, belong TO the group OF so-called
iuXatumu-, because II bears "a high tenn
through the membrane. The proportion
ai tle substance iu extract, to all appear
aucc. is ye.y slal. IL IS estimated az frac-
t'r, ~ per cont. which, II correct. we
should have Co.. do with matter whose effect
upon b" organisms attacked with tubercu-
'''.S goes iaI beyond what - known , Us of
iA' iHaIest drugs. Regarding the manner
A N.-.l the specific action of the remedy
oA iNt frG.l-.. tissue ~ 10 be resented,
various lgpHtnc,l- may naturally be put
Forward. without wishing 10 affirm that
ly Vow Affords the best explanation, |
Mould say that proceed myself in tho fol-
Nii' manner. Iubcrcie bacilh produced
"".l growing .u living tissues, the
'.t d- lu artificial cultivatiOns, con-
''t certain substances which Vari-
o--N and notably unfayOrably inhu-
once 'ae living clements IN their vi-
'1.'t. among these Is a substance which
I'd .-r'au degree Of concentration kills
o. '. -.''- tut living protoplasm that it
'"-,e- .ui'a condition that Weigert de-
,.h'.' t- cyasulation necrosis. In the
.' p. ihl- become naCotic, the bacillus
.'.- such UuAyorable conditions of nOur-
+... .'l ihAt % can grow no more and
N4t...s dies
NrNa.Es O. BlCCIfI II POUND.
Iai, eSi la.as the remarkable phonome-
l.t. i1 an organism newly attacked |
'.'. tuberculosis, for instance in Guinea |
- spleen aud liver, which then are COW !
e' WIN gGay uOluies numbers of tacilli !
-.' i'lH'. whereas they are rare or wholly /
N' "Aen iue enormously enlarged |
'.. consist, almost entirely Of whitish |
-'a.~Ate 20 igt condition Of coagulated I
....4.a.e, such .s ID often found in cases Of 4
-''o'aI death IN tuberculosis Guinea /
as. H'is.e bacillus cannot. therefore. an |
'-.. '.'oe- q, great distance, for a8 1
81 .' al.acks certain extension growth /
~. 'ariius subsidies and herewith the 4
',tA u'A o. the uecrotlsing substance. |
" 1.Al oi reciprocal compensation thus /
,,~' causing the vegetation of the /
,sii.,a O"cih 70 remain so ex.raordl- |
...l al rest as cited, as Tor in-
J'Iyr ID lupus aud scrofulous glands. |
..|L eases Tho ffat,avalt.v |