The sun., 1891-01-16
KOCH REVEALS THE SECRET.
ME TELLS WHAT INGREDTENTS ENTER
INTO HIS REMEDY
The Lymph Cous,sts OF n Giycerine Extract
Derived from Tabercie Baeiiii-It In Hn,-
possible Yet 90 Fully Explain 1ts 1nnn-
euce upon Tube rcuIous Tissue.

Derived from Tubercie Bsesiii-It II Im.
possible Yet 90 ruiiy Explain 1ts Inan.
euce Upon Tubercuious TSssue.
BERLIN. Jan l5-The secret OF tho ingredi.
ents entering Into the composition OF Prof.
Koch's lynph is given to-day to tho world.
Prof, Koch says:
since publishing. two months ago. the re-
suits OF my experiments with the new remedy
Tor tuberculosis. many physcians who re-
ceived tho preparation have been enabled TO
become acquainted with Its properties through
their own experiments. 80 far as have been
able to review the statements published and
the communications received by letter. my
indications have been FULLY and completely
confirmed. The general consensus OF oplp-
ion is that the remedy has a specific
effect upon tubercular tissues. and Is therefore
applicable IA very delicate and sure reagent
for discovering latent and diavnosin doubtful
tuberoulons processes. REGARDING the cura-
tive objects OF tho remedy. most reports agreo
that. despite the comparatively short duration
OF its application. many patients have shown
moro or lrss pronounced Improvement. 1t has
beeu affirmed that in not lew cnsos
even cure has been established Stand
lug quite by itself is the assertion
that the remedy may not only be dan
geroue in cases which have advanced too
far. a fact which may forthwith be- conceded.
but also that 1. actually promotes the tuber-
cuious rro, ess being therefore Injurious.
During the past ak weeks myself have had
opportunity to bring together further expert
encos touching the curative effects. and dag
nostic application OF the remedy In tho cases
OF about ljD sufferers from Tuberculosis OF the
most varied types In this city and 10 the hos
rital. I can ouly say that everything have
iatterly seen nccoris with my previous obscr-
vations. There has heen nothing to modify In
what before reported.
As long as 1t was only q question OF prov
ing the accuracy OF my Indications It was need
less for any one 10 know what the iemedy con-
tsined or whence it was derived. On the con-
trary. suLssrucn, testing would necessarily
be more niused the lees uoopie know Of tho
remedy it. eli. Now. aiter sufficient csnrflrma-
tory testing. tho importance Of the remedy
is proved. my neat task ia TO .H'end my study
OF tho remedy beyond the leid whore 1t has
hitherto been apple and. il possible. to ap-
ply tho principle underlying the discovery to
other diseases THIS task naturally demands
. full knowledge o, tho remedy. Therefore
consider that the tims has arrived when the
requisite indications in this direction shall DO
made. This is done in what follows:
Before going into the remedy itself. deem
It necessary. for the better understanding OF
its modo Of operation to tell briefly the way by
which arrived at the discovery. II healthy
guinea pig be inocuiated with the pure Guilt
walton OF German kultur OF tuberce bacilii.
tho wound caused BY the inoculntion mostly
closes over with sticky matter and appears
in its early days to heal Only after ton TO
fourteen days n hard nodule presents Itself.
which, soon breaking. forms Nm ulcerating
sore which continues until tho animal dies.
"Quite different condition Of things occurs
when guinea pig already suffering from
fuhorcul0aia n IA inoon1ated n m
cessfully inocuated from four to six weeks be-
fore Is best adapted for this purpose. In such
an animal the small indentation assumes the
same sticky covering at tho beginning but
no nodule forms. On the contrary. on the
day following or the second day after
the incubation. the place where the lymph
is injected shows strange change.
It becomes hard and assumes Q darker
sSlo.ins Which is not confined e the !nosula
until It attains diameter Of from .05 to cen:
tlmetre. In few days It becomes more and
alton which usually heals rapidly and perma.
HentlS Ha vt wtth9ut any cutting into the adjacent
Thus tho Injected tubsrcular hecilli quite
1ie from ous shected With III sereaiosis. This
Ss Ss.a s . ns' rssu n'H lsss Ss
Ss rs p1 at s
boiling heat or by means Of certain ch9micals.
Thls peS%pllsa1E ,s1. 'ses followed Sp In a. ssc
bacii alter being diluted With u water might
guinea pigs skin without anything occurring
beyond local suppuration."
injections belong to the simplest and sufest
means OF producing suppuration Tree from ltv-
Tqber.uons guinea pigs. on tho other hand.
tit.es Of such diluted cuI.iyations: n fact.
the strength Of Ihe dose. an injection which is
n0. su,liSion, to produce ihs dsath :, the sni,
% T. ES;a5i
ms svs .ad
able improycmsut in their condition soon su.
Ing inoculation wound becomes rmalier and
ere OF Il, which 4
IS reduced the hody becomes better nourished.
and the morbid process ceases unless It has
tshes from exhaustion. by this means the
basis Of . cuIa,iye process against tuberculo-
-. Against. the "a tactical application OF such
dntqas = de- dead ,u.si Gle Iasl! there DFS
aIe NOT "bsorbed at the incubation points nor
DO they iisnpnear In nnoher, way; but for .
long time renIn,n unbalanced and a., s,ngendsr
tting. therefore, ilIendrd to exercise a healing
effect on tn" tubrrculouS process must be q
soinLl. substance which would BIZ l!Niyiated to
aceltnin extent hy lhe Gu Ids q the body float
ing around the uDercle bacti, and be trans
ierred In y iairly RAJ i'd manner to The juices of
tho bo y. while the substance producing sup
purn,ion hpI,nrantly remains behind 10 the
tubcrauIa, bIci or dissolves but very slowly.
The only important point was, therefore. to IN
duo: ou, SIDE tho bony the p,osess gong @. on
tubsroular bncllli alone the curative su bstan
"rhis demanded time and toll. until finally
,soIuton o. giyseIine n eb,alpine an shsSsiys
tic fluid 30 obtained made further sIpea.
pents on animals, and finally on human
sicisns t" enable them 70 repeat tho exper..
treatment consists OF Rlycerine extract do
rivod rom the pure, cultivation OF tuberqe
6Acilli. Into the simple extract thero naturally
passes rom the tuDsreu!sr bacilli. besides the
n g Der esa
Il contains certain quantity q min.
unknown extractive mat OF. some Of thsse
substances can be removed IRON II tolerably
Aaailv. The affective sub6tRDC0 la inSOlubl0 In