Evening journal., 1891-01-16
KOCH'S CURE DESCRIBED.
The Discoverer Tells the World
All About 1t.
-a-
SEVERAL CRITICISMS ANSWERED.

The Great German Physician Narrates the
Manner in which his Discovery was
Made and Says That while II Is Young
Yet Many Cures Have Resulted.
| BERLIN, Jan. 16-The long talked OF
secret Of the ingredients entering into the
composition OF Professor Koch's famous
| lymph Ia now given to the world at large.
Professor Koch says: "Since publishing,
two months ago. the results OF my expert
ments with the new remedy for tubercu-
losis, my indications have been fully and
completely confirmed. The general CON
census OF opinion is that the remedy has
a specific effect upon tubercular tissues,
and is therefore applicable as very deli
cate and sure regeant for discovering latent
and diagnosing doubtful tuberoulous pro
cesses.
Some Cures Established.
Regarding the curative effects OF the
remedy most reports agree that. despite
the comparatively short duration Of its ap-
plication, many patients have shown more
or less pronounced improvement Ii has
been affirmed that in not fey eases even
a cure has been established.
Charges Against the Lymph.
Standing quite by itself is the assertion
that the remedy may not only be danger
Gus Ia cases which have advanced too far
"a fact which may forthwith be conceded
but also that it actually promotes the tu-
beroulous process, being therefore injuri-
GUS. During the past six weeks myself
have had opportunity to bring together
further experiences touching the curative
ELECTS and diagnostic application OF the
remedy IN the cases of about l50 sufferers
| from tuberculosis Of the most varied types
IN this city and in the Moabit hospital /
can only say that everything have latter
ly seen accords with my previous observa-
tions
Now, after sufficient conflrmatory test
ing the Importance OF the remedy Ia proved.
My next task is TO extend my study Of the
remedy beyond the field where It has hith-
erto been applied, and If possible TO apply
the principle underlying the discovery to
other diseases
How the Discovery Was Made.
"This task naturally demands a full
knowledge of the remedy. Before going
into the remedy itself deem il necessary
to state briefly the way by which arrived
at the discovery.
II healthy guinea pig be inoculated
with the pure cultivation OF German kul-
tur Of tubercle bAcilli, the wound caused
by the incubation mostly closes over with
sticky matter and appears, in its early
days, 20 heal. Only after ten to fourteen
days hard nodule presents Itself which.
soon breaking. forms an ulceratinp sore
which continues until the animal dies.
Tho ntTsm. NJ.
Quite different condition of things oo.
ours when guinea pig already suffering
from tuberculosis is inoculated. In such
the small indentation assumes the same
sticky covering at the beginning, but no
nodule form.
"On the contrary, on the day following
or the second day after the incubation the
place where the lymph is injected shows a
strange change It becomes hard and as
suines darker coloring, which Is not CON
lined to the incubation spot, but spreads
to the neigboring parts until il attains a
diameter OF from .05 TO centimeter. Ina
few days it becomes more and more mani
fest that the skin thus changed is necrotic.
finally falling off, leaving fat liberation
which usually heals rapidly and perman-
entity
They Might he Injected.
Thus the injected tubercular bacilH
quite differently affect the skin Of a healthy
guinea pig from one affected with tuber-
culoss.
This effect is not exclusively produced
with living tubercular bacilli but is also
observed with the dead bacilli, the result
being the same whether, as / discovered
by experiments at the outset, the bacilIi
are killed by a somewhat prolonged apuli.
nf m lou n.
or by means of certain chemicals. This
peculiar fact / followed up in all direc-
tions, and this further result was obtained
that killed pure civilizations Of tuberuu-
lar bacilh, after being diluted with water.
might be injected in great quantities un-
der healthy guinea pigs skin without any
thing occurring beyond local suppura-
tion.n
iThe Nature OF the Remedy.
After an extended technical description
Of the various stages OF his discovery, DR..
Koch thus describes the new remedy: ct
consists Of glycerine extract derived
from the pure cultivation Of tubercle
bacilh Into the simple extract there
naturally passes from the tubercular
bacilh besides the effective substance. all
the other matter soluble in 80 per cent
of glycerine. Consequently, it contains
a certain quantity of mineral salts. color
ing substances and other unknown ex-
traetiye matter. Some of these substances.
can be removed from it tolerably easily.
The effective substance is insoluble in
absolute alcohol 1t can be preoipitated
by it, though not, indeed, in q pure CON
dition, but still combined with the other
extractive matter. 1t Is likewise insolubla
in alcohol
The coloring matter may also be remov-
ed, rendering it possible TO obtain from the
extract colorless dry substance contain
ing the effective principle in a much mors
form than the original CIV
cerine solutions. For application in prac-
tice this publication of the glycerine sx-
tract offers no advantage. Regarding the
Of the more effective sub
stance only surmises may, for the present.
be expressed. II appears to me to be de-
rivative from albuminous bodies
1t does not belong to the group Of SO
called toxalbumens, because it bears high
temperature, and in the ditalyser goes cas-
ly and quickly through the naem brane.
The proportion Of the substance in the ex-
iract TO all appearances is very small Il
IS estimated at fractions - l per cent.
which, If correct, we should have to do with
! matter whose effect upon organisms at
sacked with tuberculosis goes far beyond
what is known TO us Of the strongest drug.r
Killed By Cattle Thieves
CoRPUs CHRIsrI Tex. Jan. R-Ths