New-York tribune. [volume] (New York [N.Y.]) 1866-1924, 1891-01-16
DOCTOR KOCH'S LYMPH.
THE NEW REMEDY FOR TUBERCULOSIS.
sHp SECRET OF ITS CoMrosITIoN-ITs CURA-
TIVE PEoPEkII Es-THE DISCOVERIES
FAITH UNDIMINIsHED

fubeTclc bdclIIl Professor Koch SAYS.
since publishing, two months ago. the results
of my experiments with the new remedy for
tuberculosis. many physicians who received the
preparstion have been enabled 10 become ac-
ouainted with its properties through their own
governments. SO far as ! have been able 10 re-
view the statements published and the COMMUNE
cations received by letter my indications have
been fully and completely confirmed The gen
era consensus of opinion is that the remedy has
a specific effect upon tubercular tissues, and Is
therefore applicable as very delicate and sure Tea
rent for discovering latent and diagnosing doubt
mi tuberculOus processes.
Regarding the curative effects of the remedy
most reports agree that despite the comparatively
short duration Of lis application many patients
have shown more or less pronounced improve
ment. 1t has been affirmed that in not few
cases even a cure has been established. Stand
IL c.e by ltse.. Is the assertion that The remedy
may not only be dangerous IN cases that have
advanced too far-a fact that may forthwith De
cOnceded-but also that it actually promotes the
tuberculouS process, being therefore injurious.
DurinC the past SIN weeks | myself have had
opportunity TO bring together further experiences
thuching the curative effects and diagnOstic ap-
nication oil the remedy III the cases of about
l50 sufferers from tuberculosis of the most varied
types in this city and in the MOaDit Hospital.
! can only say that everything ! have latteTly
seen accords with my previous observations. There
has been nothing TO modify III what | before
reported.
accuracy of my indications il was needless for any
one 10 know what the remedy contained or whence
il was derived. On the contrary. subsequent test
ing would necessarily be more unbiased the less
PEOPLE know of the remedy itself. Now. after SUI.
fcient cOniirmatory testing and the importance Of
the remedy is proved my next task IS 10 extend
my study of the remedy beyond the field where
il has hitherto been applied, and il possible 10
apply the principle underlying the discovery, +
other diseases. This taSl naturally demands a full
that the time has arrived when tho requisite
indications in this direction shall be made This
is done in what follows.
Before going into the remedy itself, | deem
il necessary. for The better understanding OF its
mode of operation, 10 state briefly the way by
which ! arrived at the discover. If healthy
guinea-pig be noculated with the pure cultiva-
ton Of German ku!tUr OF tubeGc.c b0cilh. the
wound caused bv The incubation mostly CLOSES
over with sticky matter and appears j. lis early
days. to heal ONLY after ten 10 fourteen days
hard nodulc presents itself. which. soon break
ing, forms an ulccratlnA sore. which continues
until the animal dies.
quite different condition of things occurs
when a guinea pig already suffering from tuheT-
culosis is inoculaled An animal successfully in
oculated from toUr 10 SIN weeks before Is best
adapted for this purpose In such 81 animal the
small indentation assumes the same sticky cover
ing AT the beginning. hat no nodulc foriAS. on
the contrary on the day following or the second
day after the incubation, the place where the
lVu.ph is injected shows a strange change. II
bcc5ues hard and assumes darker coloring
which is not confined 20 tie Ejaculation spot. hu'
spree is 10 the nciIhboring parts. until II atanS
q diameter OF IRON 10 10 ttiliIIflit III
few days it becomes more ard more manifest that
the skin thus charged is necr'tlc finally falling
oil, leaving a fat liberation, which usually heals
l. pldly and permanently without any cutting
into the adjacent lymphatc glands Thus the
In eccd tuhcrcular bacil affect quite differently
The skin Of healthy sdinea-lig from one affected
with tuberculosis.
This effect is not exclusively produced with
living tubercular baclli. but is also observed with
the dead baciN, the result being the same whether
as 7 discovered by experiments at the outset, the
l,,,i "A nToOnutt
ton OF 4 low temperature or boiling heat. or by
means of certain chemicals This peculiar fact
foil WED I'D in all directions. ant this further
result was obtaincd-tLat killed pure civilizations
OF tubcrcular bacilh. after being diluted IN water
might be injected in great quantities under healthy
guinea pigs skins without any elect occurring
Ieyonl local sLPpuTatOn
Professor Koch here interpolatcs note that such
Injections belong TO the simplest ana suIeSt means
pf producing shppuTtion free from living bacteria.
~Tuherculous guinea pigs. on the other hand.
are killed by the injection Of very small quantities
OF such diluted civilizations In fact, within SIN
- forfy-eicAt hours, according 10 the strength OF
,hp dose an in cotton which IS not sufficient 10
produce the death of the animal may cause eA-
tended necrosis TO tie skin IN the vicinity OF me
Mace of injection. II TIE clIuCon IS SUI luFtlcr
fiIutad mill u is scarcely visibly CloudCu, the
animals lnOCulated remain alive, ana notlccahc
i,nprovcment III their condition soon suprrNchcS.
il the injections are continued a FaIa oI Iu-i
one to two days, Tie ulccrailnS incubation wound
becomes smaller and finally Sc; J. over, when
otherwise il never does: the sac OF me swollen
lvmphatic glands Is reduced. the body becomes
ierfer nourisLed. and the morblI process ceases.
unless il has gone too far, II which case the animal
perishes from exhaustion, ......;. 49,.
" Nv nj, means the basis OF a curative pro
pess against tuberculosis was eS'ap4IShej A1'H>t
tie nractical application Of such dilutoAs OF
5aod tuberce bac.ih there presented itself the
lact that the tuherce baciiIi are not absorbed al
the incubation points nor DO theS uls"PPr" IA
another way but for long time remain uI-
changed and eHccnder greater or Smaller sup
curative foci. Anything, therefore, lH~Hued ~
exercise a heane effect on the tubercu.ons ptJ'T9S
must he soluble substance WAlch "OuH oc
laviViafed 10 a certain extent by the HuldS o. 'e
body floating around the tubeFc.e bacAIi ana pe
in fairly RAPID manner U Ihe JuI,To
Of the body. while the substance pIOouc!nS sup
purati1n aDpaYcntlY remains bchi'd III Vt
tutercular bacIli, or diSsoives but very Slowly
The only important point was, theIeloit, - 40
1uce outside the body tie process gong on Ihs'c
If possible and 70 extract from the tuocIc'iN
baclU alone tie curative substance. ~
"Iuis demanded time and tOI unlil Hna.,
succeeded with tie aid of a 80 TO - per cent
s"lnti,n Of rIycerine in obtaining al effective
subst; nee from the tubercuhr bacllh. W.. u.
fluid 81 Obtained / made further eApclIncA 10 Va,
animal, and finally on human DeineS' 80 eiaIIc
fluids were given 10 other physicians 20 enaof-c
them 10 repeat the experiments. Ire rrNt"S
which is used in the new treatment CONSISTS OF "
glycerlne extract derived RON ule PuaG extract
tLera naturally passes from the tubcrcullT piciII'
besides The effective substance, an 1ne otNe rsc-
ter soluble in 30 per cent LN''I4i' -,
nuently II contain, a certain quantity Of mineral
salts. coloring substances. and other unknown eN
removed wed T." from il Neraby easily The effective
substance is insolubIe in absou alcohol II can
be precipia,ed by it, thooga not d[ ,Ea o N
ptvty,c,;ye MATTE Ii is Likewise insolublc IN
sicohol Thc coloring mater may ais be re-,
moved rendering it possible tn Obtain IRON we t'c
extract coorlcSs dry substance con1aIIlil'- td
effective prjuciplr in much more concentrated
form ttab The original glyccrnc solutions tor
application IN practice tins putinrah,o cc,,ee thc
s1bSt,nres 40 eliminated are unesscntal for me
human orga1ism The process Of purihca,lYn
would make Tie cost Of the remedy unnecessary
high clio ,,ore effect
i've Substances. only surmises can for me PIeSf;no
l.o me 10 ~ NtIIN.'t''