Mineral Point tribune. (Mineral Point, Wis.) 1869-1938, 1890-12-04
An Extended Article Describing the
Operation Of the Much Heralded
Remedy.
Consumption Can Certainly be Cured
in Its Early Stages if Prop
erly Treated.
Some Interesting Experiments Made
by DR.. Koch With Very Salts
factory Results.


Further communications on the cure of
tuberculosis and experiments which Dr.
Libbertz and Staff Surgeon Pruhl perform
ed relating thereto under Prof Koch's di-
rection. In this article Prof. Koch says
he is yet indisposed TO indicate the source
from which the curative matter is derived.
Neither is he ready to explain the method
of preparation. The reason he gives is
that the experimental work has not yet
been brought to completion. He states,
however, that the curative lymph itself
can now be obtained from DR.. Libbertz,
whose address is No. % Luenberger
Strasse, Berlin.
The lymph is described as consisting Of
brownish transparent liquid 1t is so
prepared as to be p. oof against deterora-
ton. When, however, it is diluted with
water to the necessary degree for use, the
matter is liable to decay. 1t is necessary,
therefore, that the atenuations should be
perfectly steriiized by heat and preserved
in wadding covering or prepared with a
solution Of phenol so percentage strong,
When taken into the stomach, the cura-
tive matter proves to have no effect. 1t
must be applied simultaneously by means
of valveess syringe. The kind of syringe
recommended by Prof. Koch is one furnish
ed with a small, hollow rubber ball. This
syringe approved itself to him during his
ARCHAEOLOGICAL experiments It's merit is
that it can be easily and surely rinsed with
absolute alcohol and kept in perfectly
anticeptic condition. In thousands of cases,
he says, where it has been used for sub
cutaneous injections, not single abcess
resulted.
When the curative matter is applied to
patient the usual course is to inject it
under the skin Of the back, between the
shoulder blade and in proximity to the
Ioins. The experiments show that human
beings are
MUCH MORE SUSCEPTIBLE
to the effect of the substance than are
guinea pigs, which have been largely used
in the courseCf the Investigations. Two
cubic centimeters of the fluid applied to a
guinea pig produced little if any, appar-
ent effect Twenty five hundreths of a
cubic centimeter, however, intensely
affected a healthy, full grown man who
was subjected to Experiment Prof.
Koch experimental with the fluid upon
his own body and describes the effect. He
injected twenty-five hundreths of cubic
centimeter of the fluid under the skin of
his upper arm. Three or four hours after
this injection was made he experienced a
contraction of the limbs and marked
feeling of lassitude. At the same time he
felt desire to cough together with diff
entity Of hraathine- -Lhage
creased rapidly, and, in the fifth hour, he
experienced an unusually violent rigor.
The shlyering lasted for nearly an hour,
and was accompanied with nauseau and
vomiting. The temperature of his body
rose to 39' Centigrade. After period of
II hours the symptoms began to abate, the
temperature of the body declined, and on
the following day resumed its normal de-
gree. The heaviness of the limbs and the
feeling of lasitude, however, continued
for some days, during which time the
point on his arm where the injection was
made continued to be painful and remain
red. The experiment thus far conducted
showed that the lowest limit of effective
strength of the fluid in a healthy human
body is one-hundredth of cubic centlnet-
or. When this amount is applied to a
healthy human subject it produces little or
no reaction. The same result follows
when the fluid of the strength is applied
to a diseased person who is suffering from
other than the tuberculosis affections, but
in persons affected with tuberculosis the
same quantity produces q strong, general
and local reaction. The general reaction
cons sts of an attack Of fever, which usual
ly begins with shiverjng; the temperature
of the body rises to over 80, and, in some
instances, even to Al degrees centigrade
At the same time pains in the limbs are
noticeable. The patient coughs, expert
ences much irritableness and nausea. In
some cases there is noticed slight icteric
Oaundice like cOorng on eXanima re-
sembliLg measles, ON the neck. The
symptoms just described begin to manifest
themselves four or FIVE hours after the in
lection of the curative substance. The
patient is much affected by the attack in
duced by the fluid, and, after it is over,
FEELS COMPARATIVELY WELL.
even better in fact, than before the injec-
ton The second, or local action produc-
ed by the injection of the fluid In patient
suffering from tuberculosis eau best be
observed in persons whose suberculous af-
fections are visible. as for instance, in the
case of persons suffering from lupus. The
changes which ensue in these cases show
ed in a surprising manner this specifically
anti tuberculous effect of TIE remedy
Within few hours after an injection OF
the fluid has been made under the skin Of
the back, the lupus sores begin to swell
and redden. During the fever which the
patient experiences as already described,
the swelling and reddening of the sores in
crease until finally the lupus tissue as
sumo, in places, dark brown tins and a
nj .otic condition. After the subsistence
of the fever the swelling of the lupus sores
gradually decreases and possibly disappears
within two or three days Meanwhile,
however, the lupus eenters have become
covered with an incrustation, formed by
exhuding serum which dries up as it
reaches the air. These incrusations form
into scales which fall off after two or three
weeks
In some instances the effect just 1escrib-
ed is produced after a single incision of
the curative matter when a red scar
is left. The changes are absolutely limit
ed in extent to such portions of the skin as
are clearly recognized as lutus In tuber-
eo'osis of the lympathic glands, bone ar
ticulations, etc, the local reactions are
less striking, but are still clearly percep-