Morning journal and courier., 1890-11-15
From All Quarters. PROF. KOCH'S DISCOVERY How His Remedy Acts on a
 Healthy Man. BIRcHaLL HANGED AT WOODSTOCK. Serious Collision on the Pennsylvania Railroad. TERRIFIC EXPLOSION OF DYNAMITE. l Thirty Bodies of the Serpent
 Disaster Recovered.
TERRIFIC EXPLOSION OF DYNAMITE.
PRoFEssos. KooH,s LYMPH

cnt L1Qu1d.NO Emect Rr00uce6
 When Taken Into the Stomach
 Must be Applied sub-Cutaneously-
 The Professorss Experiment. With
 the Fluid Upon His own Rody.
 BERLIN, Nov. 14.-The article by Pro- lessor Koch in this weeks number of the Deusche Medinizische Wochenschrift Ger medical weekly is entitled: Further Con- munication on the Cure of Tuberculosis and Experiments which Dr. Libbertz and Staff Surgeon Pruhl Performed Relating Thereto under Professor Koch's Direction" !" In this article Professor Koch says that he is as yet unprepared to indicate the source from which the curative matter is derived. Neither is he ready to explain the method of preparation. The reason he gives is that the experimental work has not yet been brought to completion. The lymph is described as consisting of brownish transparent liquid. It is so prepared as to be proof against deterioration. When, however, it is diluted with water to the necessary degree for use the matter is sliable to decay. It is necessary there fore, that the attenuations should be per fectly sterilized by heat and preserved in wadding covering, or prepared with so- lution of phenol 50 per cent. strong. When taken into the stomach the curative matter proves to have no effect. It must be ap- piled sub-cutaneously by means of valve less syringe. The kind of syringe recom- mended by Professor Koch is one furnished with small rubber ball. In thousands of cases, he says, where it has been used for sub-cntaneous injections not single abscess resulted. .s
 When the curative matter is applied to g patient the usual course is to inject it un- der the skin of the back, between the shoulder blades and in the proximity of the Joins. The experiments show that hu- man beings are much more susceptible to the effect of the new substance than are guinea pigs, which have been largely used in the course of the investigations. Two cubic centimetres of the fluid applied to guinea pig produced little if any apparent effect. Twenty-Five -hundredths of cubic centimetre, however, intensely affected healthy, full grown man who was subject- ed to experiment.. Professor Koch experi- mented with the fluid upon his own body and describes the effect. He injected twenty -five-hundredth of cubic centi- metre of the fluid under the skin of his upper arm. Three or four hours after the injection was made he experienced a contraction of the limbs and a marked fao of 1oo k,,Ia | <hA h, felt desire to cough, together with diff culty of breathing. These symptoms in- creased rapidly and, in the fifth hour he experienced an unusually violent rigor. The shivering lasted for nearly an hour and was accompanied with nausea and vomiting. The temperature of his body rose to 39.6 0. After period of twelve temper of the body declined and on the The heaviness of the limbs and the feeling of lassitude, however, continued for some days, during which time the point on his arm where the injection was made continued to be painful and remained red. The experi- ments so far conducted show that the low est limit of effective strength of the fluid in a healthy human body is one hundredth of a cubic centimetre. When this amount is applied to healthy human subject it pFOuuces uttio UT uO TcdCblOu. Iho balflc result follows when fluid of this strength is applied to deceased persons who are suffering from other than tuberculosis, but in persons affected with tuberculosis the same quantity produces strong, gen. eral and local reaction. The general re- action consists of an attack of fever which usually begins with shivering, the tenn
 perature of the body rises to over 39 O., and in some instances even to fl 0. At the same time pains in the limbs are noticeable. The patient coughs, experi- ences much irritation and great exhaus- ton. Some patients also suffer nausea and vomiting. There is noticed in some
 cases a slight icteric coloring or exanthe
 ma, resembling measles on the chest or
 neck. The symptoms just described be- gin to manifest themselves four or five
 hours after the injection of the curative substance. They last from twelve to fif-
 teen hours. The patient is not much af
 fected by the attack induced by the fluid, and after it is over feels comparatively
 well. even better in fact than before the | iy,saction