The Iola register. [volume] (Iola, Allen County, Kansas) 1875-1902, 1886-02-05
THE GREAT DISCOVERY.
An Explanation Of Pasteur's Plan
to Check Hydrophobia.
The Way In which the Virus IL Mede and
Iuoculated Success of the Treat
ment-The Difficulty OF Founding
Hydrophobic Hospitals.


All the world knows that four chill
lren from Newark, bitten by mad-dOg.
December 2, 1885. were sent to France
to undergo NJ. Pasteur's treatment
against rabies. Since then another
patient. named Kaufmann, has arrived
from america. 1t will be a useful
thing 70 show in a precise manner, &C
cording TO the information gained in
the laboratory of NJ. Pasteur. the way
in which people who are bitten are
treated. The simplest method will be
to follow what was done to the four lit
tie children.
These children arrived in Paris, De-
cember n. That same evening they
We're brought to the laboratory in the
Rue Ulm, and M. Pesteur declared
himself ready to inoculate them imme-
diately, Notwithstanding that the inocu-
lations are usually performed by DIR.
Grauclier, Professor OF the Paris Medi-
cal Faculty. at about eleven o'clock the
morning OF each day. NJ. Pasteur, not
having taken his doctors degree in
medicine, can not, according to French
law. treat any human malady, can not
perform any medical operation on =
man, and can not even legally inoculate
aperson.
The matter used for incubation is
composed of veal broth, perfectly pure,
exempt from any microbe, and in which
has been dissolved little of the marrow
of rabid rabbit. The broth and the
marrow must be carefully prepared.
The broth is made after well-known
methods with veal which has been boiled
in water. 1t is then put in glass re-
ceivers of spherical form. with long
necks, which are Theoretically sealed
by melting the necks over a lamp.
aIhese receivers are then submitted for
bali an hour under pressure at a heat of
1l5 degrees cenlrigrade (239 degrees
Fahrenheit) in digester somewhat SIM
liar to that of Papin digester and
those used by investigators In ply sics.
This boiling is intended 10 entirely de-
stroy all germs the broth may contain.
To make matters more certain the retOrts
are left in stove heated to 35 degrees
centrigrade (95 degrees FahrcnheIt).
The germs develop if they have not
been DESTROYED, and the broth becomes
clouded When it remains clear one
can decant it, taking precautions for
excessive cleanliness. into other little re-
forts, known as Pasteur retorts, or in
some similar receptacle.
To get the marrow one must trepan
two rabbits at least each day in the
laboratory. To do. that the animal is
stretched on a dissecting board. to
which it is firmly attached by its four
legs. Then it is chloroformed. One
can tell that it is thoroughly asleep by
its regular respiration, and having lost
its consciousness it can not resist this
regular breathing by any jerking
movements. One Sits the skin of the
upper part of the Uranium Longitude
nally. One removes. with the help OF
a surgical instrument known as the
trcpan, a small round piece from the
skull, taking great care not to touch
the membranes of the brain. A man
must have acquired a good deal of skill
through practice to do this. That done,
one inoculates with the help of little
hypodernic syringe. under the first
membrane, or dura mater. little OF
the infected broth which one has
had kept for that purpose. One stitches
together the wound and leaves the
rabbit to recover. On its awakening
the rabbit seems to be as little troubled
as it did before the operation took
place.
after the incubation of very viru
lent broth rabies declares itself without
fail in the rabbit at the end of six days
Twoo three DAYS later the animal dies
of complete exhaustion Or paralysis.
Then one takes the marrow, taking
care to let no foreign germ get mixet
with it. and hangs il up in special flask
perfectly sterilized, and containing
caustic potash, to thoroughly dry thu
air inside of them. The fla ks ar,
placed in room carefully kept up at
heat of twenty degrees centigrade (sixty
eight degrees Fahrenheit.) This ex
posure to dry atmosphere and con
slant temperature is intended to pro
duce a weakening of the rabie viru
contained in the marrow. According
to the length of time that the marrow
remains in the dry air for instance, IL
one. TWO, up 10 ten VI iiitCcu I'd o-oh'
has what NJ Pasteur calls marrow o
one. two, ten or fifteen days strength.
and so on, becoming less and less viru
lent. When one wants to use 1t he cut
off little round piece of about cen
ti-aetre in length, which is mixed witt
~ broth in a quantity suitable TO
treating four or five persons.
The first evening each of the Newarl
children received half pravas or hypo
dermic syringe full of broth with mar
TOW of thirteen days strength. Al
adult receives each time three-quarter
of syringe or a whole syringe full
The morning after at eleven o'clocl
each child received half syringe
the broth and marrow of twelve days
and after the second day they come ever!
morning toithe laboratory to receive tn
Ejaculation. Each day marrow wa
used which was one day younger. an
therefore one day stronger. 30 IN
children were inoculated Ct the end 9