davidaulloa/AmericanStories huggingface dataset:
Der Demokrat. (Davenport, Iowa) 186?-1868, 1863-07-02
ii, Nenfc;s ss'2tmlj&iec,a
e 8 E77-7T7 -TTTT1 p n 4NTr17 rT1CT
'Suu-! 4*-~t: ~=Sou!s
--E-t-.- "a s.4t+I.}4,- i.;nE uy}E;E}i

ulrb Der i Inter utdnet. ia fetnen, beianntsn 9slalei 'elnen' &c.
mdsbIt&sr BoI obtattta., wssu'bas pu tlts.iun frtsab ls&a eia-
s g!sss.. a h , sssi s1 s:is gatt''l ~ J'''9't s"tt 9f44e' t''
|Gt,itritt; 5O,,Gta,,. 5gainth fttj.
.,n1be26lbe. ...,z3. .Yn96: 2abrmaalnEn T.,
Der Demokrat. (Davenport, Iowa) 186?-1868, 1863-07-02

"s asn' sstis. III ls.t 1T eay y. ibaaft tt.tsAltsa,e
g.redrturstn .rbalt.n: er' MIN ben ht&t pe
euptrten t26Al tts- Ebals vsrtbttbt8en. HE:9
hulns 2rupsen fnb pcbl poft,t" 'Gwtujt bat
ieu aqnptquarttsr tn Sbtppsnsburs.} t>7u;
-~~. Rtp.5 . h, l26a SUIT
Wsnn2 Sc ouh In Ger Ndbs @aftfngtpns fftn
{eate, 70 H. ROD nod bic BlSsidtttt, pestenssn,
(tn.m ftruerrn Dortrtn8.n Gtntalt: ~ stbun,,.
? Cst @teunSfttlme mao BEN sglqter' tte
! ], gRetftn,dt" !iessn bel W~ilmtneten bttttts55+ um
|a.asn unfere Blndab.(biif life .auf3ulaufen; 81
t. Sn b.r s1te Don @lmin8tpn5tabtn f&t ls3ne
|arcbe Msnoe Gonferibirtrr unb @olbattn 5rtr,
ldan,t.- @te leieen Der CONFEDERATION Mtt.t~
Adnb 'unb taben beretts msbrsrt @efe&te tefan.
ben. Nne4Norb. Carolina .'Grupptn Nnb pom
Stf. Dapts mad dnbern 9taaten bec, bert. 3beil
ttt un,ufrtseenbtt unhr itnsn i'm nstsn 3unsb.
@tm. softer sat, ben autorttdt,,i, tn 8attins.
ton bte Dtsnfe a1tr Meunmonatstluppen tn-bte-
fem Depar!tment ptsen ofs1ttt. ,Sk balten
' "a ,,s25s sSunt:
"W.br .alS bic 9dlft BON Seq Mtun.E tfafsf
tn Marplanb nrb, marihtrttn s; 9plorrtu ,nu6
Y%rnn(Ylsanitn. GupS,he ltere Daserjlgfq b.
e1sttn bttftlbsn. xs.4iA 49,, :
gtnp 5mtt6 cine Brtaabt III faneuf &orps.! Die
na.tRsnI Dasen bietr &olonneanb1'.U. StHlBe,
AdGnst,44 sic eianbrn meit yHpb brtit In MRasSs
lamb. 9aufn>f @tlf gttb:: ,unb, lanse, 3use
BON Wftlbtn dnb a1etn In Waftin0ton golhtp
BON tbntn sefoblsn tporbtn:' Som 7gttt r. sber
St0Sue 1tdl mad @tratnttn attlteben wetben.
@ea.rn farnsn fsrnsre 10. lNarn Rsbenen
Der Demokrat. (Davenport, Iowa) 186?-1868, 1863-07-02

@a1Itsbur8t&5jE9aKN =.
Die Observation-Disclosures. unfrs
3f3sg %;s; st,ss Co., t'.', =; s9s sSis 4 fsa s ss.eas:
Ten I'm GumberlanDttat ser16rt unp fsssntMs
g%uplRun9en fort. .:i, NJ. Al :
@tu. RnntiYe ltD.r 1T bas y. BAT { tleltenbs
gufd.turatn srbaltsn. CT pttb ben ht&t pt
euptren. a6Al bts -2bals vsrtbttbtSen! "!:7
nufut 2rupsen fnb mobl poftst .'Gwtaj eal
{au 4anptquarttsr In Sbtppsnsbur8.{ .>7ar
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
TKHHE w X.

The events Of the they developed viii ee
faithfully Siven that the public may be advised TO
its progress the results Of battles: the condition Of the
coniendng armies and all that Affects the great struggle
home and abroad for the overthrow of the Rebeoa
In addition the Senfia<l will contain the CURRENT
NEWS OF the day, CHOICE MISCELLANY, STATE
ITEMS the latest reports Of the NEW YORK and GIN
CINNATg GENERAL aud CATTLE MARKETS, the COB
dition Of the MONEY AMI STOCK MARKETS in a word
it will be the effort Of the Proprietors OF the nfin1
give columns interest for all classes Of readers and
such information will be especially adapted 10 the
well being Of the citizens Of Indiana
The Sntiad will continue 10 represent; aud stand by
the regular organizations Of the Democratic party State
and National sustain the principles and policy they shall
and support the candidates they may nominate.
We have no agents. The low prices for subscrption
will allow il. We therefore AK Democratic
friends-all who desire the Of sound principles
TO aid in the extension Of the circulation OF the SRo
Daily and Weekly until they shall least Teach every
Democratic family in Indiana The press is most inn
porant agent in directing Alright the public mind and ali
that is needed to give the Democratic party permanent
rule il the enlightenment Of the people 10 It's prnci
piles and policy. II shall be AIM with all the ability
possess faithfully advocate Democratic sentiments
and me assures. for believe that doing best
promote the true interests Of the country.
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
GO. 2I2.)


LIMITED STATES OF AMERICA. DISTRICT OF IN
DIANA, SS-
WHEREAS A libel Of information has been fled In the
District Court Of the United States within and for the
seventh Circuit and District Of Indiana, the 18th
DAY OF January, 1868, by John Hanna, Esq. Attorney
OF the United States, for he district of Indiana, against
the following described and effects Of William
J. HOlcomb, to-wit Three Promssory Notes, all dated
lat day Of November 1885, for $500 EACH with interest
from date payable in ], and years from date, re
spectively said given by William W Garrard TO said
Hoicomb; the said notes are secured by certain
mortgage real estate in Laporte, Indiana, for a
violation Of the Powers Of act Of Congress or July
IL 1882 entitled AN act suppress Instruction pun
ish treason and rebellion, TO seize and c0niscate the
property Of rebels and for other and praying
against said property. and that the same may be
condemned and scld as enemies property.
Now therefore. in pursuance Of the monition under
the seal Of all court directed and delivered do
herebv give public notice 10 all persons claiming said
property any part thereof any manner interested
therein that they be and appear before the said District
Court Of the United States be held at the city ofndan-
spols in and for the District Of Indiana the third Mon
day ofFebruary next at Of the forenoon OF that
then and there nterpose their claims and 10 make
their ale ations in that behalf
ID. G.. ROSE. L. s. Marshal,
Per l. ;. BIGELow, Deputy.
Attest:
JONI X. RIA. Clerk feb3-dlt
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
Attest: JoHS II. RIA
mo. 7I1)
rTSrrED STATES OF AMERICA, DISTRICT OF IN


FTyrTED STATES OF AMERICA, DISTRICT OF IN
L DIANA. IS:
wHxHrss libel Of information has been fled in the
District Court Of the United States within and ioT
the Seventh Circuit and District Of Indiana, the 18th
day January. l163, by John Hanna, ESQ, Attorney
Tor The United States for the District Of Indiana against
the following described credits AND effects Of one William
J. Hoicomb. to-wit Four Prumissory Notes, all dated
March 3Ut $751; for $3.50 90 EACH payable IN l. 2 and
years respectively from the lst October 1851 with IN
tere-t; said evenly John j. Oaks TO one
Seth way and by him assigned and transferred 10 said
Hocomb aud secured BY mortgage certain real estate
In Lapore county Indiana for violation OF the powers oil
Congress- approved July IL, 1862, entitled An
suppress Instruction To punish treason and rebel
on seize and conscate the property ofrebels and for
purposes and praying process against said propey
and that the may be condemned and sold as
enemies property.
Now therefore, pursuance Of the monton under the
Of said court directed and delivered do here
by give public notice all persons claiming said propry,
part thereof ia any manner Interested therein,
that they be and appear before the said District Court oil
the United States be held at the city OF Indianapolis,
IN and for the District Of Indiana the third Monday OF
February next o'clock Of the forenoon OF that
day and there ntepose their claims and to make
their allegations ia that behalf.
ID. G.. ROSE, U. s. Marshal.
Per l. 5. BIGELow, Deputy
Attest:
IOaS r. RIA Clerk. feb3-dl3t
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
no Oh
No IA
TINTED STATES or AMERICA, DISTRICT or IN
DIANA, IS
soHS II. RIA. Clerk

No. pa
TINTED STATES or AMERICA. DISTRICT OF IN
DIANA, SIS
Whereas libel Of information has been fled in the
District Of The United States within and for the
Seventh Circuit and District Of Indiana the 18th day OF
January, 1865 byJohn Hanna Esq Attorney othe United
the District Of Indiana against the following de-
credits moneys and effects OF certain per
sons unknown. to-wr SO 90 in cash In the hands Of
j. ". Forthe. also the OF S75 90 in cash in the
hands q X. Is. hcCann for violation of the
powers Of Congress- approved July II entitled
IAN suppress nSurreciOn 10 punish treason and
rebellion and conScae the property II rebels
and for other purpOSe, and praying process against
said cash, and that the sane may be condemned and
sold Is enemies property.
Now. therefore, pursuance Of the montion under the
seal % said Court directed and delivered do here
by give public notice all claiming sait cash,
or part thereof in any interested therein,
that they and appear eeor the ssd the District Court
OF the United States be held az the city Of Indianapolis,
in AMI C the District Of Indiana the third Monday Of
February next O'Clock ofthe forenoon Of that cay,
then aad there inerpose their claims and make their
allegations that behalf
%. q. ROSE. United States Marshal,
By l. ;. BIsKL0w, Deputy.
Attest
JoHS H. RIA. Clers. febS-dl4t
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

Wn H. GEE6G Co:
Gents freely give you liberty make of the fol-
lowing certificate the value DEMONSTRATION Water which
lean recommend in the highest
Ny wife, who attacked with pain in the shoulders,
whole length Of back, and in her limbs, with Palpaton
Of the Heart attended with Falling of the Womb, Dy
menorrh0a. and Irritation of the Bladder. l called
physician, who attended her about three MONTHS when
be le her worse than he found her. | then employed
one the best phys clans could find, who attended her
for about nine m-nths aud while she under his
she did suffer quite much pain; he finally her
up and said "he1 case lrdS i1curdbe " For said ne
''sie hrs such cOnsbnatinR ofc0n ILIfRts, that naeGi
cine 0irea rar operates GgIiRSf other of her
dffcuEseS. About this time she commenced the Of
Constitution Water, and utter astonishmeni, al
most the fret dose seemed have the desired effect, and
she kept improving rapidly under its treatment and
now sureriniends entirely her domestic affairs She has
not any Of The Constitution Water for about four
weeks. and are happy to say that 1t has produced
spermanenteure.
wM M.VAN BENSCHOTEN.
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
So. als.l
LIMITED STATES OF AMERICA. DISTRICT OF IN


LIMITED STATES OF AMERICA, DISTRICT OF IN
u DIANA, IS:
wHKaKAs libel of information has been filed in the
District the United states within md for the
Seventh Circuit and District Of Indiana the 18th day
Of January. 1885, by John Hanna, Esq, Attorney Of
the United for the District of Indiana, against
the following described estate, credits and effects OF one
william Bell to-wCertain Promssory Notes amount
ing In the aggregate - 600, given by Robert ~.
Williams in connection OF certain real eSta IN Madison
county for violation fihe powers If an act Of Congress
approved July IL 1851 entitled AN act 10 suppress in
Surrecfion punish treason and rebellion, TO seize and
eonscste the property Of rebels, and for Other pur-
posS and praying process against said property and that
the may be condemned and sold as enemies prop
erty
Now THEREFOR in pursuance Of the mOnon under the
seal 81 said court directed and delivered do here
BY give public notice 20 all persons claiming said property
part thereof any interested therein
ha; they be and appear before the said District Court OF
the United States 20 be held the city Of indianapolis
AMI the District of Indiana. the third Monday Of
February O'Clock of the forenoon Of that day
then and there inerpose their claims, and TO make
their allies atoms IN that behalf
ID. G. R0sF, Z. s. Marshal.
Per l. 5. B!GELOW, Deputy.
Attest.
3oHN H. RIA. Clerk feb3-di4t
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
NOW Is THE TINE TO SUBSCRIBE
The sentinel for 1868

THE governmental and pslssiesi cse-s,a- - 49,
coming year wn ss-e absorbing Interest fer evvfy
citizen We are engss-d m ssgsnsis evil var. he re-
suit Of which none forrssr. Il tA-ssssns rsdea
change N the institutions and prisp.s upon -bA he
Government was foun1ed. and The destructo1 q the
liberty and rights Il The eits.su. sucA a. The
people q no ether nation have euloysd snd
which may De attributed uneQualed progress
in national prosperity and grestnes.. The issue VIII
be upon Is whether this free Governneut shall
preserved and maintained and the rights 81 States
under the Constitution perpetusied powerful central
authority permitted grow Of this war obiter
ating lines institutions. and all those checks
upon the Federal Government rights reserved By The
states which have constituted the excellence and supe
riorty Of natonAlitystafes "oue the sra" for
the common objects Firth IN the conssitution, bat,
distinct a. the tilows IN the management o. their
purely domestic Affairs These questions were Involved
the recent elections ami the voice Of the people was
most emphaicay expressed foT the "consituion as Il
Is and the Union a. II was" Never there tine
when important that the people should be thor
sughly advised the progress and condition Of public
Affairs and Of passing events people are not q Tor
self government unless with intelligent Judgment they
decide upon the questions which affect alike their own
and the public welfare.
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
NO. 2Is)

kNO. 10
VTNTTED STATES or AMERICA, DISTRICT OF IN
u DlANA-SS
whereas, libel Of Information has been fled in the
District Court q the United states within and FOR the
seventh Circuit ae District Of Indiana the 18th day Of
January. ISIS. By John Hanna $50. Attorney Of the
United state for the District Of Indiana against the fol-
owing described property % John W Cannon oitt
pair Of second hand steam engines Tor violation Of
the powers Of an act % Congress, approved July l.,
s63 entitled AN act 10 suppress Instruction 70 punish
and rebellion q SEIZE ard coufscate the property
Of rebels and for other pGposes and praying process
against said property and that the nay De condemned
and sold as enemies property.
Now therefore pursuance q the monitor der the
ea Of said Coat me directed and delivered DO here
~ give putlie al persons claiming sad property
or any part thereof IN any manner Int rested therein.
that they and app before thu "a the District
Court the United states 20 be held A. - city q In
tiAnspols In aud for the District q ndisai the 50
Monday q February next. ten O'Clock The forenoon
q thss da. then and there 10 nterpose Ler claims and
make their sl.ss 4giSsls n thAt bshAll
p. 6. ROSE. L. s Marshal.
BY I : BIGELoN Deputy
icfS X So. Cierk. feb3-dlsi
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

To the public with the conviction that has equal In
relieving the class viii u has been found
entity successful il curing and that shall
PC reSsed for forts in acng valuable remedy
N ieai meet the requirements Il patient and physi-
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
WI M.vAN BENSCHoTEN.



MK WV. III. GREGG:
Dear Nr- have for several years been afflicted with
that troublesome and dangerous disease Gravel which
resisted all remedies and doctCrs, until took Constitution
Water and you may he assured that exceedingly
pleased with the result l. has entirely cured me. and
you NAV make any Of my you may n in
gard 20 the medicine, have entire confidence in its
efficiency. Yours truly, POND SIkONG-
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
THESE FACTS ARE ENOUGH.

There class Of dscrse that produces such exhaust
ing effects upon the human constitution Diabetes arc
Diseases Of the Kidneys BLADDER and Urinary Passages
and through false odesy they eglected until they
are 20 advanced as to beyond the control Of ordinary
and "a u-eSeut the
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

vryHE uSDrRsrGSED HAVE TAKES HEyRr n.
ALyORD into partnership. and the business will
hereafter be conducted IN the name snd style q krexk
CALDWELL a ALvo<D- hCoEh q eALD"E Lii
Aarla
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

Legislature viii assemble on the sth Of Janu-
AIRY Its action will have deep interest for the
citizens Of Indiana. The SeHfinol will faithful
and intelligent report Of Its proceedings. that the
reader understand from day day what their Repre-
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
FOR SALE BY ALL pRuGGIsrs-PmcE 81.

Morgan Alien. General Agents. Ne. 80 Cliff street,
New York Wright French, s. Randolph 81. Smith 4
Dwyer - Lake -. Wholesale gents, Chicago, Illinois.
fan2s-dsru
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

VIII assemble, and the most important questions
will be brought before II for determination. On. Of
which, the Emancipation and Colonization policy q the
President viii vitality affect the future OF the country
All interesting Congressional proceedings viii be
norted IN the Se1ff1@l
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

DANVfIIE, PA, june ?, lS62.
DR.. wN H. GKrGG-Dear sir: In February, 1851,
was afflicted with the diabetes and for tive months
1 pa more than gallons of water In "a hours.
wa obliged get up often ten or twelve times du
ring the night and IN months about so pounds
in weight During the month Of July, 81, procured
bottles of Constitution Water and in two days after
using II experienced relief and after takingtw bottles
was entirely cured, after reganing usual good
good health. Yours truly,
Jy L. De WITT
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
ELDER HARNESS & BINGHAM
RARBERS.
.TEV' B.fRBER SHOP.

- sHUCRAFT HAS OPENED 4 BARBER SHOP IN
-. the new block Of John C. New two doors south Of
the Postofce on the second floor, Room No. and ,,
her- he will pleased all his old customer l.
in fail blast with six chairs oc'lV-U4!
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

Show Cards and Bills
CHECKS. NOTES
BONDS, ENVELOPES,
STOCK CERTIFICATES, DEEDS, &c. &c
POSTING BILLS
COUNTRY MERCHANTS.
show Bills, Hotel Bills of Fare, Hand /
Bills, Posters and Programmes,
Labels, Invitations. Par.
ties and BaIIs.)
BOOK WORK,
Ii EVERY DESCRIPTION.
SCHOOL AND COLLEGE CATALOGUES,
MISCELLANEOUS PAMPHLETS,
CONSTITUTIONS.
REPORTS.
wehsve one Of the most complete Printing Establish
ments in the country Our facilities for doing all kinds of
Work Book Plain or Ornamental. frs, class. We
have introduced the latest Presses and have
added,o our Type all the modern styles and employ
~. has, sr.mep We are thus enabled to furnish Jobs
promptly. to guarantee satisfaction and to accept low
,ricss
We have connected with our Job Department Adams
Superior Presses prepared Stereotype
atlow figures.
-
,
THO A0UeHe ~
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
MEDICAL,


MN RE- m = G
~ "a - - - -,
DISEASES VI The
Kidney and u adder.
These dangerous ana troublesome D'seases'
rhlch haze thus Jar kes's'ea me oest dnse,ed
I'm m, REMEDY nolc before u.s.
The CURATIVE
properties Of the medicine direct themselves the
eaus of secretion AID by so altering the condition Of the
Stomach and liver that the tarchy principle Of the food
Is NOT converted into gar so long as the system Is under
the influence ofthe
CoOSrrrr-TION UaTEp
which gives those organs time to heiI healthy
ZION water pas cured every case Oh Diabetes III WHICH
,, ..c,rs ,..vr,
oiONh ls INF ~ D. .t,,, 20 ,i,t,rE 80
bhlCh DfSl DrfOSil MI AoDOos On "iA~Ni
DISCHARGES AflEh ChlN
Diseases occurring from one and the same will be
entirely by Constitution Water, ftA<en for any
length OF time. The dose should vary with me severity
Of the disease from twenty drops to teaspoonu three
Iu., ne pam ana d ~ sa 49,
WIN Tue prOpei ie'eues nneH iy"'"eU "P " -" wv
stitutlon water, as above ulrtcteu-
DYSMENORHHA, OR PAINFUL MENSTRUATlON, AND
IN MENORRHAGIA Or PkOFUSE FLOWING.
strual aud in the one case being too little and accom-
ton which will be speedily cured by the Constitution
Water
lima , Ses, os of,be ,ngamens of that
s 80 - trovsh NV q ep-e Of he vines and dra pginv
- IN H. bsck and ,des a. a At Times accompaDed by
La- Iancida,;ng or Shooting mains through the parts
I'll IN ali ca.ss no removed nv the medicine
There is another class Of symptoms arising from lRRI
word covers much and
cases OUT OF yen .ns aootor aoe no ne9 as ,b %
.' ~ -,ai,- ,,,ara,a ,ha,,, n 80 I sne.k mora
loWs. we eanvn9 enu"e' ave .u re- n,o'S
o. SOG rect o 9 s1e
80 81 Iinness ~ vision
"
Which in the unmarried female Is constant recurring
disease and through neglect the seeds OF more grave ana
month passes without an enort being MADE 10 assist
I nsf sp and the ENDS her
ar
IFuCORRHRA. OR WHITES.
This disease depends upon an Inflammation 0i tne iu
companied by pains the back the bowels
$3.50 60 -. A.. In a., ;n;sc,io,, of table
spoonful of medicine mixed with half pint Of soft wste
morning and evening.
IRRITATION OF THE NECK OF TIE BLADDER, IN
FLAMM AXIOM OF THE KIDNEYS AND CAIAKkH
OF THE BLADDER, STRANGUARl ANDBU
ING OF PAINFUL URlNATlNG.
,..-..,.. ......,-u -or..a,. -,
FOR those diseases IL Is truiy so'eiesi ~ M
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
CONSTITUTION WATER

Hare long given up the of buchu cubes and ju-
nber the of these Diseases ana only them
for the OF a better remedy.
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

This valuable and popular Medicine has UNIVERSAL
ceved the most favorable recommendations Of the
Medical Profession and the Public as the most
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03

Diseases occurring from and the same cause will b
entirely Constitution Water taken for an
length OF time The dose should vary with the severt
Of the disease from twenty drops 10 easpoOnfu thre
times day. in During the passage Of the Calcu
ius the pam and urgent symptoms should be comoatte
with the proper remedies then followed up by the Con
stitution Water, above directed.
Daily State sentinel. [volume] (Indianapolis, Ind.) 1861-1865, 1863-03-03
READ, READ. READ.

rrate and drench the kidneys and by constant
lead TO chronic degeneration and confirmed disease