davidaulloa/AmericanStories huggingface dataset:
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
AL OF 2s
Increase in 1853 over 1852
II 81. 1871

This s gratifying result-showing as IT does, that
Notwithstanding the railroad competition for freight
merchandise, the canals more than bold their own
exceeding largely, under the rates of toll the
ceips Of last year when the railroads now carried
freight without paying canal tolls and exceeding the
ceipts Of 1851 when the tariff of tolls higher, and
when the railroads paid canal tolls au property trans
ported on them.
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
COrORers' Inquests.

CHILD ScAtDED TO DEAm-An inquest held yester
day by Coroner Gamble at 140 Leonard street upon the
body OF child near two years Of age named John Hig
gins who died from the effects Of scads received Wed
nssday last II appears that the child fell from chair
upon which II was sitting, against pot of hot soup
which stood the chair The pot upset and the
tsns went the child scading it's head and neck in
frightfu manner The jury returned verdict of acct
AAath
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
r. Pleasure TRAvELLIs

r. PLEASURE TRAvELLING.-Th Buffalo ddUel3iSey
says.-There il o more beautiful route fer a summer
excursion on this Continent than that known AZ the
'tNorthcfu tour Y from Niagara Falls TO Montreal and
Quebec by way Of lake Ontario and the river St. law
renee No line Of travel which be chosen is
replete with interest from historical associations and
certainly none can present more attractive and
ryrg scenery TO the admirers Of the picturesque The
ehrins ropds the placid gasslike lake wild, rocky
scenery and bright far spreading landscapes the
gems OF nat,re scattered along the route and well 10
they repay syeller for the journey be undertakes
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
Two PILoTs DRowNED-Mr. John Farrar and

Two PILOTS DRowHED--Mr. John FarTar and Mr.
James Johnson drowned last Wednes lay morning.
twelve miles north of the New Inlet light while In a
small pilot boat, attempting to reach the schooner Sea
Lion, Manning, from New York, bound in. The bodies,
with The boat drfted upon the beach at Federal
Pont, and found yesterday morning. They were both
married men. The wind was very high and the sea
rough, and this melancholy event caused by the
swapping Of the boat Wilmington Nv. CO. Commercial
/sg,
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
Williamsburg C,tv InteII,oerc.

NEW CATHOLIC CHrRoH-Four lots Of ground have
emily been purchased, the corner OF Leonard and
Rensen streets, in the Third ward which new and
very large Catholic church edi6ce is to be erected The
building is TO be Of brown stone about the size
the St. Peters and st. Paus church in Second street
viii be under the pastoral charge Of Mr. Mclaughlin,
Of Govanus, Brooklyn and will be completed early next
epripg
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30

PARDoNED.-President Pierce, on Friday last, eX-
tended full pardon Joseph Rosenthal, who
vcted at the September term Of the United States Dis
tct Court Of attempt to pass goods through the Bal
timore Custom House upon a fraudulent invoice The
accused was tried The of the court after the
indictment found, before it is said he had time to
receive from Germany the original bill OF goods from the
manufacturers Of whom they purchased. The diff
ference between the appraisement of Custom House
officers and the invoice as sworn to by the accused
amounted to but nine dollars it appears and the
Jury in their verdict recommended him to the mercy
the court Since he has been imprisoned under sentence
OF the court the original bill of goods has been received
from Fra nkfort by his brother before the United
States Consul that port which proves to be exactly
counterpart Of the bill to by the accused at the
the Recommendation Of the jury and the subse quent
evidence brought before him after examination into
the matter Immediately directed his release from
Observation-Disclosures Sum- april 25.
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30

Total amount inspected in 1852, (bushels) 922 533
This amount exceeds that Of any previous year. with
the exec ption Of 1S48
The revenue received by the Superintendent from all
sources amounted to SS1 49, He drew from the rea
Coolies expenses to Europe $50 oo6 70. The net
nue., therefore, was $19, 2s4 81.
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
One Crime Begets Others-Probable Murder
In Ulster Country.

from the Poughkeepsie Free Press, April %.
most horrible crime perpetTated in Ulster county
Sunday. the It'll inst which, together with the cir
cumstsnces attending the history OF those concerned
will form chapter OF exciting interest to the public
For many years q man named Benjam BOyce lived in
the mountains known the Traps, in the town OF
Rochester, in this county. He had several sons and
was found frozen to death, about mile from home, in
the mountains some IF cen or more years ago and she
buried beneath the leaves Of the forest Ben lived
alone with his children for time but finally they
were all married save one, named Eliza.
Not far from Ben's lived named Cross, who was
married. but lived unhappily with his wife. Ben knew
this and accordingly opened negotiations with his neigh
Dor, which resulted in fair exchange. Boyce took Mrs.
Cross to wife, to his home and Cross took Bens daugh
ter Eliza.
Soon after this arrangement, the woman Eliza gave
birth to daughter. But the complexion OF the child,
the color ard peculiar curl Of its har indicated that
her reputed intimacy with colored man strengthened
the conviction that the child was the progeny of the
black man and white woman. Cross did not seem to
mind this at ALL but continued to acknowledge her his
spouse and the child as his own.
The girl became fourteen fifteen years Of age when she
keduced by living in the neghborhood by the
Of Jacob Gosln He is miserable specimen Of hui
manity-a morrall Wand physically deformed brute He
Cross was about to become mother. On Sunday, she
induced to accompany Gosn into the woods and in
the course Of their walk they came to precpce about
two hundred feet high, and perfectly perpendicular Here
they stopped to talk After brief period Goslin looked
over the brink and cried out to the girl that he
woodcbuck and indicated 10 her where the animal was to
be After he withdrew step two she approached
the edge Il the rock to look when he gave her sud-
den push and she went into the awful abyss below
Strange it appear the fall did not kill her. She
struck among and stumps but survived the terri
BILE descent The injuries she sustained however, were
terrible and must fatal it said Her bowels were
rent open and her whole body bruised and manged
in horrible In this awful condition. she wled
towards habitation, and two days and nights
poed before she discovered Up to the last accounts
she is still living.
Gosln has fed tits stated that his wife was cognizan
Of the cowardy deed and it is believed urged him to it
jealousy. Officers the william,
it il hoped he may be arrested and punished The people
ere highly excited the subject, and If he is cap
tured about here he win almost certainly be subject to
Lynch law is sdered impossible for the girl to i've
hough she yet breathes.
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30

RAILROAD ACCIDENT.-On Thursday, as the six
O'Clock train from Elzabethtown N j. was passing the
baggage car which caused the rear car to turn over
its side. Fortunately, person was seriously h5hred,
although several received slight bruises The passengers
forwarded Immediately to New York with but little
delay.
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
New York Salt Springs.

From the Syracuse Standard, April 90
From the report Of the Superintendent Of the Salt
Springs learn that the entire amount of salt manufac
tured and inspected the reservation during the year.
b22 533 bushels which exceeded the amount the
previous year by 4l6 bushels OF this quantity there
was inspected at
The New York herald. [volume] (New York [N.Y.]) 1840-1920, 1853-04-30
PART SECOND.

Before Hon. Judge Boswortn
ACTION FOR LIBEL AGAINST GEORGE WILKES-THE
CASE OF THE FAT BOY.
ApRu 90 Elisha j. Latham. rs. George WiNes-hr u.
sickes having summed up on the part Oh the aeienoan
and Mr. Lincoln for the plaintiff.
The Judge in charging the jury, said that the law IN
relation to libel was that party may write or pub,
sued for il he may he can establish that is true and
if he proves it it is perfect defence The law does
not allow a man to recover for the publication 0, Inc
truth In this the article complained to be libel
ous the character Of the plaintiff as physician
says that he employed by Robinett (the deceased
and that he administered certain medicines to him which
caused his DEATH 1t cannot said that the article Inn
putes murder TO the plaintiff that he knew the med
cines deeterious or that they were administered
with any but honest expectation that they would pro-
duce favorable result If the evidence satisfied the
jury that the article is true there is an end to the case
and the defendant is entitled to a verdict They had ev
dence Of the state of Robnett health at the time the
plaintiff called to attend him. they had testimony
medicine Robnet died they had evidence of the descrp
ton of the medicines administered On the other
hand they had the testimony OF several gentlemen
of high character, and their opinion in relation
medicines which they had administered to others
they found that the death of Robinett caused by
the administration Of the medicine the defendant
titled 10 verdict the defendant failed prove his
case they would find for the plaintiff. The amount Of
damages rests in the sound discretion OF the arytakng
into consideration the position of the party in society
The plaintiff is entitled to recover the truth OF the
libel is not made out, matter how much in good faith
published how much the person who wrote 1t
believed to be true. they believed the libel to be
published with view to damage the plaintiff they we're
bound 10 give what is termed smart money but on the
other hand il they thought that the party had
able grounds for believing to be true and that he pub
shed it for information without any malicious motive it
was not for exemplary damages.
The jury in few minutes, brought IN verdict for the
defendant.
This verdict shows that editors justified in pub
fishing facts they appear in the proceedings of courts
whether before coroner's jury any other tribunal
and may perhaps tend to check the desire to
paper propretors for publications made in good faith and
az articles o. news and general information.
William Dunbar Patrick DnGy.-Action for assault
and battery alleged to have been committed by the de-
PENDANT the plaintiff on the 9th Of July 1852 from
which he suffer ed much and confined to the house
for a considerable time There defence and the
jury rendered verdict for the plaintf$90o damages.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
CREIGHTON s. Men AIR,

DEALERS IN
Harduare, Cutlery, Bar Iron, Steel, Yin
doar Sash, Building Hardware,
AGRICULTURAL IMPLEMENTS,
CARRIAGE TRIMMINGS, HOUSEKEEPING ARTICLES,
Guns, PIsToLs, &C., &C.,
Right on the Corner of King and Royal Streets
Cat the Telegraph post,)
ALEXANDRIA, Va,
WTOULD respectfully inform their friends in
w Charles county, that they are in receipt OF
an unusually large stock of goods in their line,
which they will sell upon such terms cannot fail
to please. An advertisement will not suffice to
enumerate the various articles on hand, consisting
of every description Of
Pen, pocket and table Cutlery
Carpenters and Blacksmiths' Tools
Building Materials and Farming Implements
Bar Iron, Cast and Blister Steel
Carriage Springs and Patent Axles
Morticed Hubs, and Wagon Bars
Buggy Shafts, and Carriage Cloth
Carriage Poles and Bent Fellows, &c.
Pots, Ovens, SkiIIets, Tea Kettles
Tenders, Brass and other Andirons
Axes busting and Sweeping Brushes.
We particularly invite attention to our Guns rang
ing from So to 500 each; Pistols, Game Bags
Percussian Caps, Ram Rods, &c. Our stock is by
far the LARG EST AND BEST SELECTED IN the Alex
andra market Call and see to be convinced.
Nov. II, 1852.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
LARGE AND ELEGANT STOCK OF

! A LARGE AND ELEGANT STOCK OF
! n SPRING AND SUMMER DRY GOODS.
TAYLOR & HUTCHINSON, ALEXANDRIA, Va,
invite the attention of dealers to their heavy stock
of seasonable DRY GOODS, which will be found
complete. We name in part the following, viz
! For Ladies.
Black Gro de Rhine Silk Turic and India Satin
Striped and checked, and very rich brocade do
Plain Poult de Sor do
Black green, maroon, purple & blue wat'red Silks
Black, white, green brown and brab Silk Fringes
Chally Cloths; Berage DeLaines
White Mouslin; Silk and Berage TO cut
Black Silk Points and Scarfs
Silk Grenadines; Berages and Lawns
Plain and emb'd white Grape Shawls
Black Canton Cloths and Alpaccas
Black Bombazines and Mouslanes
Black Grenadines Tissues and Beraees
Linen cambria Hdkfs. from IA cts to s9; French
worked pointed Collars; Cambria, Swiss, Thread,
Lsle, Bobbin and Valencienes Edgngs; Thread,
Kid, and cut Silk Gloves; black Silk Mtts; Grapes;
Tarlatons and Dotted Swiss Muslins: Gro de Maps
and Marsalin Silk; Parasoletts, in every variety;
Cotton, Silk and Thread Hosiery; Gauze, Merino
and Silk Vests.
For Gentlemen.
Black, brown and green Cloths
| g and Fancy Cassimeres
Silk Satin and Marseilles Nesting; Tweeds
Croton Cloths; fancy and plain Linen Drngs
Black brown green and drab Drap De Etc
Kid, Lisle Thread, Buck and Silk Gloves; black
and fancy Silk CraVats; Suspenders; Fancy half
Hose, SC, sc.
For Farmers and Planters.
Bleached and brown Cotton, in every variety
Linen Burlaps and Cotton Osnaburgs
Striped and plain Nankeen do
Blue DENNIS and Drills; heavy Linen and Cotton
Bagging; Penitentiary Plaids and Stripes fancy s.
plain Cotonades; 1914 and 1914 linen and cotton
Sheetings; Pillow Case Cotton and Linens; Huck-
aback and Russia Towelling; Satin Damask Table
Cloths and Table Linens bleached and brown Cot
ton Diaper; Marseilles and Dresden Quilts Irish
Linens, in every variety.
ALSO-Ingrain, 8 ply, List, Rag, Hemp, Cot
ton and Ventian Carpetng; Tufted Rugs; Door
Mats; Bookings Table, Floor and Stair Oil Cloths;
white and checked Mating, SC.
/ All of which will be sold upon the most accom-
nIodating terms. may 10.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
NEcCoRMICK's REAPER & NOW

NTcCORMICK'S REAPER & NOW
lV1 Ere. H. McCoRMIcK has appointed
COTTINGHAM & JOHNSON agents for the
sale of McCormick's Patent Virginia Reaper and
Reaper and Mower Combined, for 1853
This machine has been greatly improved and
strengthened expressly for the Southern market.
One of the great improvements is the shortening
Of the platform, which places the raker closer to
his work. Farmers wishing to purchase this just
ly celebrated premium machine for the coming
harvess will please send their orders early, or call
on COTTINGHAM & JOHNSON, MARYLAND
AGRICULTURAL WoRKs, No. l2l, Pratt Street
Wharf, BALTIMORE, who will give e satisfactory
guarantee to the most doubtful.
G.. & ]. continue to manufacture their last i'm
proved THRESHING MACHINES and HORSE
POWERS, with wrought axles, steel laid. Their
machines have given universal satisfaction in St.
Mary's county the last three years. Also, Rail-
way Horse Powers, with complete assortment of
Agricultural Implements.
GRAIN CRADLES, a very superior article, in
store and for sale by
COTTINGHAM & JOHNSON,
No. l2l Pratt Street Wharf, BBLrIMonE,
May l9, 1s53-tf
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
BAMBOROUGH'S WHEAT FAN.

'TENHE undersigned, Agent for the sale of this
Il justly celebrated Wheat Fan, is now offering
them at the manufacturers prices. The public are
invited to examine specimens now on hand. Nu-
merous certificates of its great superiority over all
others now in use will be shown at his store. He
refers to the following certificate of pre-eminence
awarded by the Maryland State Agricultural So
cety. VIM. BOSWELL.
jy7.
(coPY.)
s.This is to certify, that at the third Annual E1-
hibition and Cattle Show of the Maryland State
Agricultural Society, held at Baltimore the s5th
October, 1850, by the report of the Committee of
Judges, John scarborough was declared to be en-
titled to a certificate of pre-cminence over the
E1Rsr premium Offered by said Society, viz: for
his Tanning Mill" Signed in behalf of the So
cety, this 25th day of October, 1850.
CHARLES B. CALVERT, Prest.
S,M1-pr S,Enc Sec'u
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
GOOD MEDICINES :!
STABLER'S ANODYNE CHERRY
EXPECTORANT

Is confidently recommended to inyalids, as UN-
SURPASSED by any known preparation, for the cure
Of COUGHS, HOARSENESS, and other forms
of Common CoIps': BRONCHITIS, ASTHMA,
GROUP, CONSUMPTION in an Early Stage,
and for the RELIEF Of the Patient even in Ad-
vanced Stages of that Fatal Disease.
1t combines, in a scientific manner, remedies OF
long esteemed value, with others of more recent
discovery, and besides its soothing and tonic quail
ties. acts through the skin gently, and with great
efficacy, for the cure OF this class of diseases.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
WASHINGTON L. BODKlN,
Wholesale and retail dealer in
GROCERIES,


Wholesale and retail dealer in
GROCERIES,
LIQUORS AND PROFESSIONS,
CAMERON STREET, (FoRMERLY JOHN LAwsoN's, y
Opposite the Market House,
ALEXANDRIA, Va.
THE subscriber has in store a large stock O
i goods in his line, to which he respectfully calls
the attention of his friends and the public in Charles
county. He names in part:
so bbls Red Whskey; 20 bbls N. E. Rum
"a bbls domestic Gin I; 10 bbls Cordials
5 half pipes Brandes of superior quality
pipe Holland Gin
9 1-2 pipes Nj. Wine best quality
quarter casks S. Madeira best quality
10 &c S. Wine
20 bbls domestic Brandy
10 bbls old rye Whiskey, Monongahela
10 bbls Gbsons superior Pittsburg brand
Is bbls Funk's superior
IL puncheon Jamaica Spirits
l &c Scotch Whskey
90 doz London Porter
10 baskets Champagne, best brand
10 hhds Porto Ricco Sugar; 10 hhds Molasses
20 bbls crushed and pulverzed Sugar
1000 lbs Loaf Sugar. 40 bags Rio Coffee
20 bags Laguyra, IL bags old gov Java Coffee
10 boxes burnt Coffee in papers
so boxes Cheese, extra; $50 sacks fine Salt
200 sacks ground alum Salt
10 half chests gunpowder Teas; 5 do Y. Hyson
Spices of all Kinds, Mustard. Starch Buckets
Brooms and all the other articles usually kept in
Grocery store. ~
10000 lbs Shoulder Bacon; 5000 lbs Mddling do
5000 lbs Hams, all of best quality.
WASHINGTON L. BODKIN.
Alexandria, Va, June 8, 1852.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
IMPLEMENTS.

AGRICULTURAL IMPLEMENTS.
VX7E have on hand, and are constantly receiv-
w ing, which we offer for sale at the lowest
market prices, large and complete assortment of
the most approved
agricultural and Horticultural Implements,
amongst which are Eagle S. S. and Eagle Ploughs,
Minor s. Horton do. Rough s. Ready do, Hillside
and Subsoil do; Road Scrapers, Harrows, Ox-Yoke,
Cultivators, Root Pullers, Churns Corn Shelters,
Hay and Straw Cutters, Fan Mills, Horse Powers
and Treshers, Corn and Cob Cruslers, Hay Presses,
Grind Stones and Fixtures, Log Chains, Hoes,
Rakes, Shoves, Spades, Forks, Pruning Saw and
Knives, Garden Reels, Post-hole Augers, Ox-Bows,
Garden Cultivators and Ploughs, sc. sc.
SEEDS.-Always on hand Tin season. full
supplies of Field and Garden Seeds such as Cloper,
Timothy, Herds Grass, Seed Corn, Oats, Potatoes,
Wheat, sc.
Fruit and Ornamental Trees
We have been appointed agents for Parsons s.
Co.'s celebrated nurseries, which will enable us to
furnish Trees of every description reasonable
terms as any similar house in this country.
.N.8N'URES.-Agents for the sale of Professor
Mapcs' celebrated Super Phosphate of Lime, Bone
Dust, Agricultural Salts, sc.
O. All orders promptly attended to.
ADDISON s. MEADE,
Union street and Potomac Strand, near
Ferry Slip, ALEXANDRIA, Va.
March II, ls53-tf
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
PATENT WHEAT
FANS

IrTNHE subscriber, only agent for the manufacture
Il ers In Alexandria, is prepared to supply far
mers with the above Fan at manufacturers prices.
1t has received upwards of SO Premiums, and is
admitted by the best Farmers to be of the best
Fans in use for cleaning wheat of all its impurities
They are made in the strongest and best manner,
and are more durable than most other Fans made
in the country.
To be had only at the Agricultural Warehouse
Fairfax Street, of r. S. HUCK, Agent.
lie 80.
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
J. w. & e. REYNOLDS,
Farmers and Planters Agents

No. rs LIGHT STREET WHARF,
BALTIMORE,
II EEP constantly on hand, for sale, at lowest
M Cash prices, a general assortment of select
GROCERIES for family use, consisting in part
ofFLOUR CANDLES
Brown SUGARS SOAP
Loaf SU CARS NAILS
TEAS COTTON YARN
COFFEES RICE
MOLASSES VINEGAR
BACON STARCH
SALT PEPPER
CHEESE SALT PETRE, &C.,
which thec will be pleased to sell on a credit ofsix
months to good and punctual dealers, who consign
produce to them. They also solicit consignments
of produce for sale, and make liberal advances on
consignments when desired. All orders for goods
Of other kinds, promptly filled at cost without
charge. They also furnish Guano, Plaster and
Cloverseed on the best terms
Baltimore, Sept. p, lS52-tf
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
FOREIGN AND DOMESTIC DRY
GOODS.
G.. K. WIT.MER e. BRO.

FOREIGN AND DOMESTIC DRY
GOODS.
G. K. WIT.MER & BRO,
Zone door west oc Sarepta Hall, King street,)
ALEXANDRIA, Va.
~ X. w. & B. have Just received a large and
W. elegant stock of SPRING AND SUMMER
GOODS, embracing very rich assortment Of
Brocade, poult de soir, glace and watered Silks
Plain black and figured of very rich and superior
lustre
Satins, Grape de Paris and twisted Silks
Black Bombazines and Canton Cloths
Alpaccas of every quality
Challes, Armenians, Persians, Berage de Lans,
Mouslins, and every other description of La
dies Dress Goods
Ladies' Habits, Undersleeves and Collars, with a
full stock of all other French Embroderies
Grape and Cashmere Shawls
Moreens and Grass Cloth for Skirts
Cloths, Cassimeres and Vestings, Tweeds, &c.
Single mill Cloth, Cashmerets and Drop e'Les,
for spring and summer coats.
Osnaburgs, Burlaps, heavy Ducks, Domestcs and
all other kinds of goods suited to the wants of
farmers and planters
Carpetngs, Oil Cloths, Druggetts, Rugs Mat
tings SC.
With their largely increased stock and facilities
for trade, they enabled to offer greater induce
ments than heretofore. They therefore respectful
ly solicit their country friends and dealers generally
to call and examine their stock before making their
purchases.
z5Orders will receive special and prompt atten-
ton.
Alexandria, Va, April IA, 1853
Port Tobacco times, and Charles County advertiser. (Port Tobacco, Md.) 1845-1898, 1853-08-04
SYABLER'S
DTARRHEA CORDIAL

Is pleasant Mixture, compounded in agreement
with the rules Of Pharmacy, of therapeutic agents
long known and celebrated for their peculiar eff
cacy in Curing DiARRHEA, and similar affec-
Itons of the system. In its action. it ALLAYs
NAUSEA and produces 4 healthy condition of the
LIVER. thus removing the cause at the same time
that it cures the disease