Centella asiatica

Centella asiatica, commonly known as Indian pennywort, Asiatic pennywort, spadeleaf, coinwort or gotu kola, is a herbaceous, perennial plant in the flowering plant family Apiaceae. It is native to tropical regions of Africa, Asia, Australia, and islands in the western Pacific Ocean. It is consumed as a culinary vegetable and is used in traditional medicine.
Centella grows in temperate and tropical swampy areas in many regions of the world. The stems are slender, creeping stolons, green to reddish-green in color, connecting plants to each other. It has long-stalked, green, rounded apices which have smooth texture with palmately netted veins. The leaves are borne on pericladial petioles, around 2 cm (0.79 in). The rootstock consists of rhizomes, growing vertically down. They are cream in color and covered with root hairs.
The flowers are white or crimson in color, born in small, rounded bunches (umbels) near the surface of the soil. Each flower is partly enclosed in two green bracts. The hermaphrodite flowers are minute in size, less than 3 mm (0.12 in), with five to six corolla lobes per flower. Each flower bears five stamens and two styles. The fruit are densely reticulate, distinguishing it from species of Hydrocotyle which have smooth, ribbed or warty fruit. The crop matures in three months, and the whole plant, including the roots, is harvested manually. It is a highly invasive plant, rated as "high risk". Centella has numerous common names in its regions of distribution.
Centella asiatica is indigenous to the Indian subcontinent (including Sri Lanka), Southeast Asia, parts of Australia, and wetland regions of the Southeastern US. Because the plant is aquatic, it is especially sensitive to biological and chemical pollutants in the water, which may be absorbed into the plant. It can be cultivated in drier soils, including sandy loam, as long as they are watered regularly enough (such as in a home garden arrangement).
Centella contains pentacyclic triterpenoids and trisaccharide derivatives, including asiaticoside, brahmoside, asiatic acid, and brahmic acid (madecassic acid). Other constituents include centellose, centelloside, and madecassoside. Approximately 124 chemical compounds have been isolated and identified from Centella asiatica. Long term use on the skin can cause severe health problems including: skin irritation, intoxicated blood, red eyes and problems with the lymph nodes.
In Burmese cuisine, raw pennywort is used as the main constituent in a salad mixed with onions, crushed peanuts, bean powder and seasoned with lime juice and fish sauce. Centella is used as a leafy green in Sri Lankan cuisine, being the predominantly locally available leafy green, where it is called gotu kola or vallaarai. It is most often prepared as malluma, a traditional accompaniment to rice and vegetarian dishes, such as lentils, and jackfruit or pumpkin curry. It is considered nutritious. In addition to finely chopped gotu kola plants, the gotu kola malluma may be eaten with grated coconut, diced shallots, lime (or lemon) juice, and sea salt. Additional ingredients are finely chopped green chilis, chili powder, turmeric powder, or chopped carrots. The Centella fruit-bearing structures are discarded from the gotu kola malluma due to their intense bitter taste. A variation of porridge known as kola kanda is also made with gotu kola in Sri Lanka. Gotu kola kanda or Vallaarai kanji is made with well-boiled red rice with some extra liquid, coconut milk first extract, and gotu kola purée. The porridge is accompanied with jaggery for sweetness. Centella leaves are also used in modern sweet pennywort drinks and herbal teas. In addition the leaves are served stir-fried whole in coconut oil, or cooked in coconut milk with garlic or dhal.
In Indonesia, the leaves are used for sambai oi peuga-ga, an Aceh type of salad, and is also mixed into asinan in Bogor. In Cambodia, Vietnam and Thailand, this leaf is used for preparing a drink or can be eaten in raw form in salads or cold rolls. In Bangkok, vendors in the Chatuchak Weekend Market sell it alongside coconut, roselle, chrysanthemum, orange and other health drinks. In Malay cuisine it is known as pegaga, and the leaves of this plant are used for ulam, a type of vegetable salad. C. asiatica is widely used in various Indian regional cuisines. In Bangladesh and India (specifically in West Bengal), Centella is called Thankuni Pata and used in various dishes, one of the most appetising of which is the pakora-like snack called Thankuni Patar Bora; made of mashed Centella, lentils, julienned onion and green chilli.
In traditional medicine, C. asiatica has been used to treat various disorders, dermatological conditions, and minor wounds, due to its anti-inflammatory and anti-oxidant effects, although clinical efficacy and safety have not been investigated in human clinical trials. In animals trials, C. asiatica and its extracts has been shown to relieve cognitive impairment and treat neurodegenerative conditions by way of reducing the production of reactive oxygen species and promoting neuron survival and growth. It has also shown promise in treating endocrine-related disorders like diabetes and obesity, by reducing insulin resistance and aiding in the regulation of blood glucose levels and appetite, and endometriosis by reducing inflammation. Furthermore, C. asiatica has shown to reduce the generation and activity of osteoclasts in Osteoporosis models in mice. C. asiatica may address several skin conditions such as acne, vitiligo, eczema, and increase collagen production. The compounds asiaticoside and asiatic acid may relieve hypertension, atherosclerosis, and ischemic heart disease by promoting endothelium function and reducing pathological apoptosis of heart muscles. C. asiatica's pro-mitochondrial, anti-imflammatory, and anti-oxidant effects have shown benefits in treating digestive diseases in animal and in vitro studies. Asiatic acid may also aid in treating respiratory diseases by targeting inflammation. In animal and cell trials, C. asiatica has been shown to promote cancer cell death.
Contact dermatitis and skin irritation can result from topical application. Drowsiness may occur after consuming it. There has been three cases of liver disease associated with use over the span of multiple weeks.
C. asiatica has been shown to activate telomerase more than any other known compound yet discovered: 8.8-fold. This exceeds the activation by other known telomerase activators: oleanolic acid 5.9-fold, Astragalus extract 4.3-fold, TA-65 2.2-fold, and maslinic acid 2-fold.
In the context of phytoremediation, C. asiatica is a potential phytoextraction tool owing to its ability to take up and translocate metals from root to shoot when grown in soils contaminated by heavy metals.