Document: NRC Regulatory Guide
Document ID: a5cfec96-8785-464b-ada8-dc4424b90606
Document Type: regulatory_guide
Title: Quality Assurance for Radiological Monitoring Programs
Source: NRC Regulatory Guide Division 4
Source URL: https://www.nrc.gov/docs/ML0630/ML063060429.pdf
Revision Date: 2023-06
Chapter: 
Section ID: RG-4.15
CFR Part: 
CFR Title: 

Content:
epared and analyzed in the same manner as the sample. In an ideal situation, the result of an analysis of the laboratory control sample should be equivalent to (give 100 percent of) the TARGET ANALYTE concentration or activity known to be present in the fortified sample or standard material. The result normally is expressed as percent recovery. See also QUALITY CONTROL SAMPLE. Appendix A to DG-4010, Page A-4 laboratory duplicate: See DUPLICATE, LABORATORY. matrix spike: See SPIKE. measurement quality objective (MQO): The analytical data criteria of the DATA QUALITY OBJECTIVES, which are project- or program-specific and can be quantitative or qualitative. These analytical data criteria serve as measurement performance criteria or objectives of the analytical process. MARLAP refers to these performance objectives as MQOs. Examples of quantitative MQOs include statements of required analyte detectability and the UNCERTAINTY of the analytical protocol at a specified radionuclide concentration, such as the action level. Examples of qualitative MQOs include statements of the required specificity of the analytical protocol (e.g., the ability to analyze for the radionuclide of interest (or TARGET ANALYTE) given the presence of interferences). method uncertainty: Reference to the predicted UNCERTAINTY of the result that would be measured if the method were applied to a hypothetical laboratory SAMPLE with a specified analyte concentration. Although individual measurement uncertainties will vary from one measured result to another, the REQUIRED METHOD UNCERTAINTY is a target value for the individual measurement uncertainties and is an estimate of uncertainty before the sample is actually measured. See also UNCERTAINTY and REQUIRED METHOD UNCERTAINTY. method validation: The demonstration that the method selected for the analysis of a particular analyte in a given matrix is capable of providing analytical results to meet the project’s MEASUREMENT QUALITY OBJECTIVES and any