engram cell / cellule d'engramme
Synonyms: cellular engram, engram neuron, memory engram cell
Synonymes : engramme cellulaire, neurone d'engramme
Group: Nonhuman animal, Human, Neurophysiology
Groupe : Animal non humain, Homme, Neurophysiologie
Definition: Engram cells are "[...] neurons that are activated during an experience, that have undergone enduring physical or chemical changes and that can subsequently be selectively reactivated to produce the retrieval of that experience or inhibited to prevent its retrieval." (Tonegawa et al., 2018, p. 485).
Définition : Les cellules d'engramme sont des « […] neurones activés au cours d'une expérience, qui ont subi des modifications physiques ou chimiques durables et qui peuvent ensuite être réactivés de manière sélective pour produire la récupération de cette expérience ou inhibés pour empêcher sa récupération» (Tonegawa et al., 2018, p. 485).
Broader term: neuron
Terme générique : neurone
Related terms: optogenetics, silent engram, reconsolidation, engram, synaptic consolidation, long-term potentiation, prefrontal cortex, storage, dentate gyrus, amygdala, systems consolidation, extinction, hippocampus
Termes associés : optogénétique, engramme silencieux, reconsolidation, engramme, consolidation synaptique, potentialisation à long terme, cortex préfrontal, stockage, gyrus denté, amygdale, consolidation des systèmes, extinction, hippocampe
Selected bibliography: Dixsaut, L., & Gräff, J. (2021). The medial prefrontal cortex and fear memory: Dynamics, connectivity, and engrams. International Journal of Molecular Sciences, 22(22), 12113. https://doi.org/10.3390/ijms222212113 [Study type: literature review / Access: open], Guskjolen, A., & Cembrowski, M. S. (2023). Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory. Molecular Psychiatry, 28(8), Article 8. https://doi.org/10.1038/s41380-023-02137-5 [Study type: literature review / Access: open], Josselyn, S. A., & Tonegawa, S. (2020). Memory engrams : Recalling the past and imagining the future. Science, 367(6473), eaaw4325. https://doi.org/10.1126/science.aaw4325 [Study type: literature review / Access: open], Rao-Ruiz, P., Visser, E., Mitrić, M., Smit, A. B., & van den Oever, M. C. (2021). A synaptic framework for the persistence of memory engrams. Frontiers in Synaptic Neuroscience, 13. https://doi.org/10.3389/fnsyn.2021.661476 [Study type: literature review / Access: open], Ryan, T. J., de San Luis, C. O., Pezzoli, M., & Sen, S. (2021). Engram cell connectivity: An evolving substrate for information storage. Current Opinion in Neurobiology, 67, 215–227. https://doi.org/10.1016/j.conb.2021.01.006 [Study type: literature review / Access: open], Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R. (2015). Memory engram cells have come of age. Neuron, 87(5), 918–931. https://doi.org/10.1016/j.neuron.2015.08.002 [Study type: literature review / Access: open], Tonegawa, S., Morrissey, M. D., & Kitamura, T. (2018). The role of engram cells in the systems consolidation of memory. Nature Reviews Neuroscience, 19(8), 485–498. https://doi.org/10.1038/s41583-018-0031-2 [Study type: literature review / Access: open], Willems, T., & Henke, K. (2021). Imaging human engrams using 7 Tesla magnetic resonance imaging. Hippocampus, 31(12), 1257-1270. https://doi.org/10.1002/hipo.23391 [Study type: literature review / Access: open]