Alzheimer's disease / maladie d'Alzheimer
Synonyms: Alzheimer's dementia, dementia of the Alzheimer type
Synonymes : démence d'Alzheimer, démence de type Alzheimer
Group: Human, Neurology
Groupe : Homme, Neurologie
Definition: A degenerative disease of the brain with the presence of senile plaques and neurofibrillary degeneration. Brain atrophy begins in the hippocampal region, extends to associative regions and then to frontal regions. Memory problems are the first signs of the disease. Several aspects of memory are affected by Alzheimer's disease: episodic memory (which can disrupt people's sense of identity), semantic memory, working memory (including the central administrator). Procedural memory is more resistant to the disease, and perceptual priming is preserved.
Définition : Maladie dégénérative du cerveau (présence de plaques séniles et de dégénérescences neurofibrillaires). L’atrophie du cerveau débute dans la région hippocampique, s’étend aux régions associatives puis aux régions frontales. Les troubles de la mémoire constituent les signes inauguraux de la maladie. Plusieurs aspects de la mémoire sont touchés dans la maladie d’Alzheimer : la mémoire épisodique (pouvant perturber le sentiment d'identité des personnes), la mémoire sémantique, la mémoire de travail (notamment l’administrateur central). La mémoire procédurale résiste mieux à la maladie et les amorçages perceptifs sont préservés.
Broader term: memory disorder
Terme générique : trouble de la mémoire
Narrower terms: pure progressive amnesia
Termes spécifiques : amnésie progressive pure
Related terms: Semantic and Episodic Memory Test, reminiscence therapy, retrograde amnesia, anterograde amnesia, confabulation, accelerated long-term forgetting, Provoked Confabulation Test
Termes associés : Test de mémoire sémantique et épisodique, thérapie par réminiscence, amnésie rétrograde, amnésie antérograde, confabulation, oubli à long terme accéléré, Test des confabulations provoquées
Diagnostic tool of: Pyramids and Palm Trees Test
Has diagnostic tools: GRECO's semantic knowledge assessment battery, DemTect, Addenbrooke's Cognitive Examination - III, Memory Binding Test, visual association test, Face-Name Associative Memory Exam, Mattis Dementia Rating Scale, MEMO test, Wechsler Memory Scale, Montreal Cognitive Assessment, Doors and People Test, Memory Alteration Test, DMS48, California Verbal Learning Test ​, Grober and Buschke test, Mini Mental State Examination, Encoding, Storage, Retrieval test, Rivermead Behavioural Memory Test
Disorder of: autobiographical memory, episodic memory, working memory, semantic memory, short-term memory, prospective memory
Selected bibliography: De Vita, D., Sagliano, L., & Trojano, L. (2023). Memory biases in Alzheimer’s disease and Mild Cognitive Impairment. A systematic review and metanalysis. Neuroscience & Biobehavioral Reviews, 152, 105277. https://doi.org/10.1016/j.neubiorev.2023.105277 [Study type: meta-analysis / Access: closed], El Haj, M., Colombel, F., Kapogiannis, D., & Gallouj, K. (2020). False memory in Alzheimer’s disease. Behavioural Neurology, 2020, e5284504. https://doi.org/10.1155/2020/5284504 [Study type: literature review / Access: open], Eustache, F., Giffard, B., Rauchs, G., Chételat, G., Piolino, P., & Desgranges, B. (2006). La maladie d’Alzheimer et la mémoire humaine. Revue Neurologique, 162(10), 929–939. https://doi.org/10.1016/S0035-3787(06)75102-5 [Study type: literature review / Access: closed], Launay, A., Taconnat, L., Vanneste, S., & Baudouin, A. (2023). Mémoire épisodique et maladie d’Alzheimer: évolution des théories et des outils d’évaluation clinique Auteurs. Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement, 21(4), 469–476. https://doi.org/10.1684/pnv.2023.1139 [Study type: literature review / Access: closed], Malone, C., Deason, R. G., Palumbo, R., Heyworth, N., Tat, M., & Budson, A. E. (2019). False memories in patients with mild cognitive impairment and mild Alzheimer’s disease dementia: Can cognitive strategies help? Journal of Clinical and Experimental Neuropsychology, 41(2), 204–218. Scopus. https://doi.org/10.1080/13803395.2018.1513453 [Study type: literature review / Access: closed], McLachlan, E., Rai, S., Al-Shihabi, A., Huntley, J., Burgess, N., Howard, R., & Reeves, S. (2020). Neuroimaging correlates of false memory in ’Alzheimer’s disease: A preliminary systematic review. Psychiatry Research: Neuroimaging, 296, 111021. https://doi.org/10.1016/j.pscychresns.2019.111021 [Study type: literature review / Access: closed], Park, S.-H., Kwon, K. J., Kim, M. Y., Kim, J.-H., Moon, W.-J., Ryu, H. J., Jang, J. W., Moon, Y., & K-ARPI. (2023). Diagnostic tools for Alzheimer’s disease: A narrative review based on our own research experience. Dementia and Neurocognitive Disorders, 22(1), 16–27. https://doi.org/10.12779/dnd.2023.22.1.16 [Study type: literature review / Access: open], Rentz, D. M., Orlovsky, I., Kilpatrick, E., & Papp, K. V. (2019). Alzheimer’s disease. In M. L. Alosco & R. A. Stern (Eds.), The Oxford Handbook of Adult Cognitive Disorders (pp. 549–574). Oxford University Press. https://doi.org/10.1093/oxfordhb/9780190664121.013.26 [Study type: literature review / Access: closed], Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021). Alzheimer’s disease. The Lancet, 397(10284), 1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4 [Study type: literature review / Access: closed]