I 
117TH CONGRESS 
2D SESSION 
H. R. 6946 
To amend the Controlled Substances Act with respect to fentanyl-related 
substances, and for other purposes. 
IN THE HOUSE OF REPRESENTATIVES 
MARCH 7, 2022 
Mr. PAPPAS (for himself, Mr. NEWHOUSE, and Mr. BUDD) introduced the fol-
lowing bill; which was referred to the Committee on Energy and Com-
merce, and in addition to the Committee on the Judiciary, for a period 
to be subsequently determined by the Speaker, in each case for consider-
ation of such provisions as fall within the jurisdiction of the committee 
concerned 
A BILL 
To amend the Controlled Substances Act with respect to 
fentanyl-related substances, and for other purposes. 
Be it enacted by the Senate and House of Representa-
tives of the United States of America in Congress assembled, 
SECTION 1. SHORT TITLE. 
This Act may be cited as the ‘‘Save Americans from 
the Fentanyl Emergency Act of 2022’’ or the ‘‘SAFE Act 
of 2022’’. 
VerDate Sep 11 2014 
20:31 Mar 09, 2022
Jkt 029200
PO 00000
Frm 00001
Fmt 6652
Sfmt 6201
E:\BILLS\H6946.IH
H6946
pamtmann on DSKBC07HB2PROD with BILLS
SEC. 2. CLASS SCHEDULING OF FENTANYL-RELATED SUB-
STANCES. 
Section 202(c) of the Controlled Substances Act (21 
U.S.C. 812(c)) is amended by adding at the end of sched-
ule I the following: 
‘‘(e)(1) Unless specifically exempted or unless listed 
in another schedule, any material, compound, mixture, or 
preparation which contains any quantity of fentanyl-re-
lated substances, or which contains their salts, isomers, 
and salts of isomers whenever the existence of such salts, 
isomers, and salts of isomers is possible within the specific 
chemical designation. 
‘‘(2) In this subsection, except as provided in para-
graph (3), the term ‘fentanyl-related substance’ means 
any substance that is structurally related to fentanyl by 
one or more of the following modifications: 
‘‘(A) By replacement of the phenyl portion of 
the phenethyl group by any monocycle, whether or 
not further substituted in or on the monocycle. 
‘‘(B) By substitution in or on the phenethyl 
group with alkyl, alkenyl, alkoxyl, hydroxyl, halo, 
haloalkyl, amino, or nitro groups. 
‘‘(C) By substitution in or on the piperidine 
ring with alkyl, alkenyl, alkoxyl, ester, ether, 
hydroxyl, halo, haloalkyl, amino, or nitro groups. 
VerDate Sep 11 2014 
20:31 Mar 09, 2022
Jkt 029200
PO 00000
Frm 00002
Fmt 6652
Sfmt 6201
E:\BILLS\H6946.IH
H6946
pamtmann on DSKBC07HB2PROD with BILLS
‘‘(D) By replacement of the aniline ring with 
any aromatic monocycle whether or not further sub-
stituted in or on the aromatic monocycle. 
‘‘(E) By replacement of the N-propionyl group 
with another acyl group. 
‘‘(3) A substance that meets the criteria specified in 
paragraph (2) to be considered a fentanyl-related sub-
stance shall not be so considered as meeting such criteria 
if such substance— 
‘‘(A) is controlled by action of the Attorney 
General pursuant to section 201; 
‘‘(B) is expressly listed in this schedule or an-
other schedule by a statutory provision other than 
this subsection; or 
‘‘(C) is removed from this schedule, or resched-
uled to another schedule, pursuant to section 201(k). 
‘‘(4) The Attorney General shall publish in the Fed-
eral Register a list of individual substances that meet the 
definition of fentanyl-related substances in paragraph (2) 
within 60 days of determining such substances meet such 
definition. The absence of a substance on any such list 
does not negate the control status of such substance if 
the substance meets the criteria specified in paragraph (2) 
to be considered a fentanyl-related substance. 
VerDate Sep 11 2014 
20:31 Mar 09, 2022
Jkt 029200
PO 00000
Frm 00003
Fmt 6652
Sfmt 6201
E:\BILLS\H6946.IH
H6946
pamtmann on DSKBC07HB2PROD with BILLS