I 
118TH CONGRESS 
1ST SESSION H. R. 3457 
To direct the Administrator of the Environmental Protection Agency to estab-
lish a consortium relating to exposures to toxic substances and identifying 
chemicals that are safe to use. 
IN THE HOUSE OF REPRESENTATIVES 
MAY 18, 2023 
Ms. LOFGREN introduced the following bill; which was referred to the 
Committee on Energy and Commerce 
A BILL 
To direct the Administrator of the Environmental Protection 
Agency to establish a consortium relating to exposures 
to toxic substances and identifying chemicals that are 
safe to use. 
Be it enacted by the Senate and House of Representa-
tives of the United States of America in Congress assembled, 
SECTION 1. SHORT TITLE. 
This Act may be cited as the ‘‘Supercomputing for 
Safer Chemicals Act’’ or the ‘‘SUPERSAFE Act’’. 
SEC. 
2. 
SUPERCOMPUTING 
FOR 
SAFER 
CHEMICALS 
(SUPERSAFE) CONSORTIUM. 
(a) ESTABLISHMENT.— 
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(1) IN
GENERAL.—The Administrator of the 
Environmental Protection Agency (referred to in 
this section as the ‘‘Administrator’’), in consultation 
with the heads of relevant Federal agencies (includ-
ing the Secretary of Health and Human Services 
and the Secretary of Energy), shall form a consor-
tium, to be known as the ‘‘Supercomputing for Safer 
Chemicals (SUPERSAFE) Consortium’’ (referred to 
in this section as the ‘‘Consortium’’). The Consor-
tium shall include the National Laboratories of the 
Department of Energy, academic and other research 
institutions, and other entities, as determined by the 
Administrator, to carry out the activities described 
in subsection (b). 
(2) INCLUSION OF STATE AGENCIES.—The Ad-
ministrator shall allow the head of a relevant State 
agency to join the Consortium on request of the 
State agency. 
(b) CONSORTIUM ACTIVITIES.— 
(1) IN GENERAL.—The Consortium shall use 
supercomputing, machine learning, and other similar 
capabilities— 
(A) to establish rapid approaches for large- 
scale identification of toxic substances and the 
development of safer alternatives to toxic sub-
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stances by developing and validating computa-
tional toxicology methods based on unique high- 
performance computing, artificial intelligence, 
machine learning, and precision measurements; 
(B) to address the need to identify safe 
chemicals for use in consumer and industrial 
products and in their manufacture to support 
the move away from toxic substances and to-
ward safe-by-design alternatives; and 
(C) to make recommendations on how the 
information produced can be applied in risk as-
sessments and other characterizations for use 
by the Environmental Protection Agency and 
other agencies in regulatory decisions, and by 
industry in identifying toxic and safer chemi-
cals. 
(2) MODELS.—In carrying out paragraph (1), 
the Consortium— 
(A) shall use supercomputers and other 
virtual tools to develop, validate, and run mod-
els to predict adverse health effects caused by 
toxic substances and to identify safe chemicals 
for use in products and manufacturing; and 
(B) may utilize, as needed, appropriate bi-
ological test systems to test and evaluate ap-
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proaches and improve their predictability and 
reliability in industrial and regulatory applica-
tions. 
(c) PUBLIC RESULTS.—The Consortium shall make 
model predictions, along with supporting documentation, 
available to the public in an accessible format. 
(d) AUTHORIZATION OF APPROPRIATIONS.—There is 
authorized to be appropriated to the Administrator to 
carry out this section— 
(1) for fiscal year 2023, $20,000,000; 
(2) for fiscal year 2024, $30,000,000; and 
(3) for each of fiscal years 2025 through 2027, 
$35,000,000. 
Æ 
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