(O) in section 485H—
(i) by striking ‘‘(a)’’ and all that fol-
lows through ‘‘The Secretary,’’ and insert-
ing ‘‘The Secretary,’’; and 
(ii) by striking subsection (b); and 
(P) in section 494—
(i) by striking ‘‘(a) If the Secretary’’ 
and inserting ‘‘If the Secretary’’; and 
(ii) by striking subsection (b). 
(2) PUBLIC HEALTH SERVICE ACT; OTHER PRO-
VISIONS.—The Public Health Service Act (42 U.S.C. 
201 et seq.) is amended—
(A) in section 399E, by striking subsection 
(e); 
(B) in section 1122—
(i) by striking ‘‘(a) From the sums’’ 
and inserting ‘‘From the sums’’; and 
(ii) by striking subsections (b) and 
(c); 
(C) by striking section 2301; 
(D) in section 2354, by striking subsection 
(b) and redesignating subsection (c) as sub-
section (b);
(E) in section 2356, by striking subsection 
(e) and redesignating subsections (f) and (g) as 
subsections (e) and (f), respectively; and 
(F) in section 2359(b)—
(i) by striking paragraph (2); 
(ii) by striking ‘‘(b) EVALUATION AND 
REPORT’’ and all that follows through 
‘‘Not later than 5 years’’ and inserting 
‘‘(b) EVALUATION.—Not later than 5 
years’’; 
(iii) by redesignating subparagraphs 
(A) through (C) as paragraphs (1) through 
(3), respectively; and 
(iv) by moving each of paragraphs (1) 
through (3) (as so redesignated) 2 ems to 
the left. 
(3) OTHER ACTS.—Provisions of Federal law 
are amended as follows: 
(A) Section 7 of Public Law 97–414 is 
amended—
(i) in subsection (a)—
(I) in paragraph (2), by inserting 
‘‘and’’ at the end; 
(II) in paragraph (3), by striking 
‘‘; and’’ and inserting a period; and
(III) by striking paragraph (4); 
and 
(ii) in subsection (b), by striking the 
last sentence of paragraph (3). 
(B) Title III of Public Law 101–557 (42 
U.S.C. 242q et seq.) is amended by striking 
section 304 and redesignating section 305 and 
306 as sections 304 and 305, respectively. 
(C) Section 4923 of Public Law 105–33 is 
amended by striking subsection (b). 
(D) Public Law 106–310 is amended by 
striking section 105. 
(E) Section 1004 of Public Law 106–310 
is amended by striking subsection (d). 
(F) Section 3633 of Public Law 106–310 
(as amended by section 2502 of Public Law 
107–273) is repealed. 
(G) Public Law 106–525 is amended by 
striking section 105. 
(H) Public Law 107–84 is amended by 
striking section 6. 
(I) Public Law 108–427 is amended by 
striking section 3 and redesignating sections 4 
and 5 as sections 3 and 4, respectively.
SEC. 6. CERTAIN DEMONSTRATION PROJECTS. 
(a) BRIDGING THE SCIENCES.—
(1) IN GENERAL.—From amounts to be appro-
priated under section 402A(b) of the Public Health 
Service Act, the Secretary of Health and Human 
Services, acting through the Director of NIH, (in 
this subsection referred to as the ‘‘Secretary’’) in 
consultation with the Director of the National 
Science Foundation, the Secretary of Energy, and 
other agency heads when necessary, may allocate 
funds for the national research institutes and na-
tional centers to make grants for the purpose of im-
proving the public health through demonstration 
projects for biomedical research at the interface be-
tween the biological, behavioral, and social sciences 
and the physical, chemical, mathematical, and com-
putational sciences. 
(2) GOALS, PRIORITIES, AND METHODS; INTER-
AGENCY COLLABORATION.—The Secretary shall es-
tablish goals, priorities, and methods of evaluation 
for research under paragraph (1), and shall provide 
for interagency collaboration with respect to such re-
search. In developing such goals, priorities, and 
methods, the Secretary shall ensure that—
(A) the research reflects the vision of inno-
vation and higher risk with long-term payoffs; 
and 
(B) the research includes a wide spectrum 
of projects, funded at various levels, with vary-
ing timeframes. 
(3) PEER
REVIEW.—A grant may be made 
under paragraph (1) only if the application for the 
grant has undergone technical and scientific peer re-
view under section 492 of the Public Health Service 
Act (42 U.S.C. 289a) and has been reviewed by the 
advisory council under section 402(k) of such Act 
(as added by section 3(c) of this Act) or has been 
reviewed by an advisory council composed of rep-
resentatives from appropriate scientific disciplines 
who can fully evaluate the applicant. 
(b) HIGH-RISK, HIGH-REWARD RESEARCH.—
(1) IN GENERAL.—From amounts to be appro-
priated under section 402A(b) of the Public Health 
Service Act, the Director of NIH may allocate funds 
for the national research institutes and national cen-
ters to make awards of grants or contracts or to en-
gage in other transactions for demonstration 
projects for high-impact, cutting-edge research that 
fosters scientific creativity and increases funda-