(12) Most Alzheimer’s disease caregivers work 
outside the home before beginning their caregiving 
careers, but caregiving forces them to miss work, cut 
back to part-time, take less demanding jobs, choose 
early retirement, or give up work altogether. As a 
result, in 2002, Alzheimer’s disease cost American 
business an estimated $36,500,000,000 in lost pro-
ductivity, as well as an additional $24,600,000,000 
in business contributions to the total cost of care. 
TITLE I—INCREASING THE FED-
ERAL COMMITMENT TO ALZ-
HEIMER’S RESEARCH 
SEC. 101. DOUBLING NIH FUNDING FOR ALZHEIMER’S DIS-
EASE RESEARCH. 
For the purpose of conducting and supporting re-
search on Alzheimer’s disease (including related activities 
under subpart 5 of part C of title IV of the Public Health 
Service Act (42 U.S.C. 285e et seq.)), there are authorized 
to be appropriated $2,000,000,000 for fiscal year 2010, 
and such sums as may be necessary for each of fiscal years 
2011 through 2014. 
SEC. 102. PRIORITY TO ALZHEIMER’S DISEASE RESEARCH. 
Section 443 of the Public Health Service Act (42 
U.S.C. 285e) is amended— 
VerDate Nov 24 2008 
04:51 Jul 23, 2009
Jkt 079200
PO 00000
Frm 00005
Fmt 6652
Sfmt 6201
E:\BILLS\H3286.IH
H3286
tjames on DSKG8SOYB1PROD with BILLS
(1) by striking ‘‘The general’’ and inserting the 
following: 
‘‘(a) IN GENERAL.—The general;’’ and 
(2) by adding at the end the following: 
‘‘(b) PRIORITIES.—The Director of the Institute 
shall, in expending amounts appropriated to carry out this 
subpart, give priority to conducting and supporting Alz-
heimer’s disease research.’’. 
SEC. 103. ALZHEIMER’S DISEASE PREVENTION INITIATIVE. 
Section 443 of the Public Health Service Act (42 
U.S.C. 285e), as amended by section 102, is further 
amended by adding at the end the following: 
‘‘(c) PREVENTION TRIALS.—The Director of the In-
stitute shall increase the emphasis on the need to conduct 
Alzheimer’s disease prevention trials within the National 
Institutes of Health. 
‘‘(d) NEUROSCIENCE INITIATIVE.—The Director of 
the Institute shall ensure that Alzheimer’s disease is main-
tained as a high priority for the neuroscience initiative of 
the National Institutes of Health.’’. 
SEC. 104. ALZHEIMER’S DISEASE CLINICAL RESEARCH. 
(a) CLINICAL RESEARCH.—Subpart 5 of part C of 
title IV of the Public Health Service Act (42 U.S.C. 285e 
et seq.) is amended by adding at the end the following: 
VerDate Nov 24 2008 
04:51 Jul 23, 2009
Jkt 079200
PO 00000
Frm 00006
Fmt 6652
Sfmt 6201
E:\BILLS\H3286.IH
H3286
tjames on DSKG8SOYB1PROD with BILLS
‘‘SEC. 445J. ALZHEIMER’S DISEASE CLINICAL RESEARCH. 
‘‘(a) IN GENERAL.—The Director of the Institute, 
pursuant to section 444(d), shall conduct and support co-
operative clinical research regarding Alzheimer’s disease. 
Such research shall include— 
‘‘(1) investigating therapies, interventions, and 
agents to detect, treat, slow the progression of, or 
prevent Alzheimer’s disease; 
‘‘(2) enhancing the national infrastructure for 
the conduct of clinical trials on Alzheimer’s disease; 
‘‘(3) developing and testing novel approaches to 
the design and analysis of such trials; 
‘‘(4) facilitating the enrollment of patients for 
such trials, including patients from diverse popu-
lations; 
‘‘(5) developing improved diagnostics and 
means of patient assessment for Alzheimer’s disease; 
‘‘(6) the conduct of clinical trials on potential 
therapies, including readily available compounds 
such as herbal remedies and other alternative treat-
ments; 
‘‘(7) research to develop better methods of early 
diagnosis, including the use of current imaging tech-
niques; and 
‘‘(8) other research, as determined appropriate 
by the Director of the Institute after consultation 
VerDate Nov 24 2008 
04:51 Jul 23, 2009
Jkt 079200
PO 00000
Frm 00007
Fmt 6652
Sfmt 6201
E:\BILLS\H3286.IH
H3286
tjames on DSKG8SOYB1PROD with BILLS
with the Alzheimer’s disease centers and Alzheimer’s 
disease research centers established under section 
445. 
‘‘(b) EARLY
DIAGNOSIS
AND
DETECTION
RE-
SEARCH.— 
‘‘(1) IN GENERAL.—The Director of the Insti-
tute, in consultation with the directors of other rel-
evant institutes and centers of the National Insti-
tutes of Health, shall conduct, or make grants for 
the conduct of, research related to the early detec-
tion, diagnosis, and prevention of Alzheimer’s dis-
ease and of mild cognitive impairment or other po-
tential precursors to Alzheimer’s disease. 
‘‘(2) EVALUATION.—The research described in 
paragraph (1) may include the evaluation of diag-
nostic tests and imaging techniques. 
‘‘(3) STUDY.—Not later than 1 year after the 
date of enactment of this section, the Director of the 
Institute, in cooperation with the heads of other rel-
evant Federal agencies, shall conduct a study, and 
submit to Congress a report, to estimate the number 
of individuals with early-onset Alzheimer’s disease 
(those diagnosed before the age of 65) and related 
dementias in the United States, the causes of early- 
onset dementia, and the unique problems faced by 
VerDate Nov 24 2008 
04:51 Jul 23, 2009
Jkt 079200
PO 00000
Frm 00008
Fmt 6652
Sfmt 6201
E:\BILLS\H3286.IH
H3286
tjames on DSKG8SOYB1PROD with BILLS
such individuals, including problems accessing gov-
ernment services. 
‘‘(c) VASCULAR DISEASE.—The Director of the Insti-
tute, in consultation with the directors of other relevant 
institutes and centers of the National Institutes of Health, 
shall conduct, or make grants for the conduct of, research 
related to the relationship of vascular disease and Alz-
heimer’s disease, including clinical trials to determine 
whether drugs developed to prevent cerebrovascular dis-
ease can prevent the onset or progression of Alzheimer’s 
disease. 
‘‘(d) TREATMENTS AND PREVENTION.—The Director 
of the Institute shall place special emphasis on expediting 
the translation of research findings under this section into 
effective treatments and prevention strategies for individ-
uals at risk of Alzheimer’s disease and other dementias. 
‘‘(e) NATIONAL ALZHEIMER’S COORDINATING CEN-
TER.—The Director of the Institute may establish a Na-
tional Alzheimer’s Coordinating Center to facilitate col-
laborative research among the Alzheimer’s Disease Cen-
ters and Alzheimer’s Disease Research Centers established 
under section 445.’’. 
(b) 
ALZHEIMER’S
DISEASE
CENTERS.—Section 
445(a)(1) of the Public Health Service Act (42 U.S.C. 
285e–2(a)(1)) is amended by inserting ‘‘, outcome meas-
VerDate Nov 24 2008 
04:51 Jul 23, 2009
Jkt 079200
PO 00000
Frm 00009
Fmt 6652
Sfmt 6201
E:\BILLS\H3286.IH
H3286
tjames on DSKG8SOYB1PROD with BILLS