I 
119TH CONGRESS 
1ST SESSION H. R. 6660 
To ensure that non-animal methods for regulatory testing are used in lieu 
of animal tests whenever scientifically satisfactory non-animal test meth-
ods are available and accepted by regulatory agencies for meeting regu-
latory requirements, and for other purposes. 
IN THE HOUSE OF REPRESENTATIVES 
DECEMBER 11, 2025 
Mr. MOSKOWITZ (for himself, Ms. SCHAKOWSKY, and Mr. THANEDAR) intro-
duced the following bill; which was referred to the Committee on Energy 
and Commerce, and in addition to the Committee on Agriculture, for a 
period to be subsequently determined by the Speaker, in each case for 
consideration of such provisions as fall within the jurisdiction of the com-
mittee concerned 
A BILL 
To ensure that non-animal methods for regulatory testing 
are used in lieu of animal tests whenever scientifically 
satisfactory non-animal test methods are available and 
accepted by regulatory agencies for meeting regulatory 
requirements, and for other purposes. 
Be it enacted by the Senate and House of Representa-
tives of the United States of America in Congress assembled, 
SECTION 1. SHORT TITLE. 
This Act may be cited as the ‘‘Replace Animal Tests 
Act of 2025’’. 
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SEC. 2. ANIMAL TESTING. 
(a) IN GENERAL.—Except as otherwise provided by 
this section, it shall be unlawful for any entity to submit 
to a covered agency, with respect to a product or sub-
stance, data that has been derived using an animal test 
method if— 
(1) a non-animal test method is available to 
meet the information requirement concerned, as de-
termined by the covered agency; or 
(2) the covered agency has issued a waiver ex-
empting the entity from a requirement for data de-
rived from an animal test method. 
(b) EXCEPTIONS.—Subsection (a) shall not apply 
with respect to— 
(1) data generated before the date of enactment 
of this Act; 
(2) data generated from an animal test method 
conducted outside the United States in order to 
comply with a requirement from a foreign regulatory 
authority; 
(3) data requested by a covered agency fol-
lowing a determination by the covered agency that— 
(A) existing data is insufficient for satis-
fying the information requirement concerned; 
and 
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(B) no scientifically satisfactory non-ani-
mal test method was practicably available when 
the testing was conducted despite reasonable ef-
forts to access a non-animal test method; and 
(4) data generated from specified animal test 
methods requested in writing by a covered agency, 
which request shall include a clear justification by 
the covered agency that available non-animal test 
methods (if any) are not appropriate for the product 
or substance concerned. 
(c) LIMITING HARM
TO ANIMALS.—In a case in 
which no appropriate non-animal test method is available 
and a waiver has not been granted by the covered agency 
concerned, the regulated entity shall— 
(1) ensure that the number of animals used in 
any animal test method is reduced to the minimum 
number possible without compromising the objectives 
of the test; and 
(2) reduce to a minimum any possible pain, suf-
fering, distress, or lasting harm to the animals used. 
(d) PENALTIES.— 
(1) REFUSALS TO ACCEPT DATA.—A covered 
agency may refuse to accept animal testing data 
generated in violation of this section. 
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(2) CIVIL PENALTIES.—In addition to any other 
penalties under applicable law, a covered agency may 
impose on any person who violates this section a 
civil penalty in an amount of not more than $10,000 
for each such violation, as determined by the regu-
latory authority of the covered agency. 
(e) GUIDANCE; REGULATIONS.—A covered agency 
shall— 
(1) not later than one year after the date of en-
actment of this Act, issue guidance on the accept-
ability and use of non-animal test methods for prod-
ucts and substances regulated by the covered agen-
cy; and 
(2) to the extent the covered agency determines 
appropriate— 
(A) revise regulations to reflect the accept-
ability of non-animal test methods; and 
(B) eliminate requirements for the cor-
responding animal test data. 
(f) REPORTING.— 
(1) PUBLICATION.—Not later than one year 
after the date of enactment of this Act, and annually 
thereafter, each covered agency shall publish a 
progress report on the use of non-animal test meth-
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ods by the covered agency and the entities regulated 
by the covered agency. 
(2) CONTENTS.—A report published by a cov-
ered agency under paragraph (1) shall specify for all 
research that is conducted or supported by the cov-
ered agency or is submitted to the covered agencies 
by regulated entities— 
(A) the number of animals used; 
(B) the species of animals used; 
(C) the types of testing for which the ani-
mals were used; 
(D) the number of waivers issued; and 
(E) the purpose of animal test methods, 
non-animal test methods, and waivers accepted 
or issued by the covered agency. 
(3) PUBLIC AVAILABILITY.— 
(A) IN
GENERAL.—The information col-
lected by a covered agency for purposes of this 
subsection shall be made publicly available, as 
soon as practicable, on an internet website of 
the covered agency. 
(B) PERSONALLY IDENTIFIABLE OR PRO-
PRIETARY INFORMATION.—Before making such 
information publicly available, the covered agen-
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cy shall omit personally identifiable information 
and proprietary information. 
(g) DEFINITIONS.—In this section: 
(1) ANIMAL.—The term ‘‘animal’’ means a live 
vertebrate non-human animal or cephalopod. 
(2) ANIMAL TEST METHOD.—The term ‘‘animal 
test method’’ means a test method that involves the 
use of live animals. 
(3) COVERED
AGENCY.—The term ‘‘covered 
agency’’ means— 
(A) the Consumer Product Safety Commis-
sion; 
(B) the Department of Agriculture; 
(C) the Environmental Protection Agency; 
and 
(D) the Food and Drug Administration. 
(4) NON-ANIMAL
TEST
METHOD.—The term 
‘‘non-animal test method’’ means a test method 
that— 
(A) does not involve the use of live ani-
mals; and 
(B) has been identified and accepted for 
use by the covered agency concerned. 
(5) TEST METHOD.—The term ‘‘test method’’ 
means a process, procedure, or approach used to ob-
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tain information on the properties of a product or its 
ingredients. 
Æ 
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