priated amount as the investment in clinical research of 
the grantee involved bears to the total investment in clin-
ical research of all eligible grantees under this section. 
(e) APPLICATIONS.—To seek a grant under this sec-
tion, an eligible academic health center shall submit an 
application to the Director in such manner, at such time, 
and containing such information and assurances as the 
Director may require. 
(f) REPORTS.—The Director shall require each re-
cipient of a grant under this section to submit an annual 
report to the Director detailing how the recipient has used 
the grant to meet the purposes described in subsection (b). 
(g) AUTHORIZATION OF APPROPRIATIONS.—To carry 
out this section, there is authorized to be appropriated 
$40,000,000 for each of the fiscal years 2006 through 
2010. 
SEC. 5. CLINICAL RESEARCH INFRASTRUCTURE GRANTS. 
(a) AUTHORIZATION.—The Director shall make clin-
ical research infrastructure grants on a competitive basis 
to eligible academic health centers. 
(b) USE OF FUNDS.—The Director may not make a 
grant to an eligible academic health center under this sec-
tion unless the center agrees to use the grant only for the 
following:
(1) Fostering the use of information technology 
to facilitate the transformation of basic research 
findings on disease mechanisms into the develop-
ment of new methodologies for diagnosis, therapy, 
and prevention. 
(2) Addressing the many obstacles impeding the 
expeditious application of new science, such as— 
(A) a lack of up-to-date information tech-
nology systems; 
(B) incompatible databases; 
(C) a lack of connectivity between aca-
demic health centers, teaching hospitals, and 
independent research institutes; 
(D) the absence of a coordinated strategy 
to enhance public understanding of, support 
for, and participation in clinical research; and 
(E) the underrepresentation of some popu-
lations in clinical research. 
(3) Sharing clinical research infrastructure 
across academic health centers to enable and facili-
tate cross-center clinical research collaborations. 
(c) REPORTS.—The Director shall require each re-
cipient of a grant under this section to submit an annual 
report to the Director detailing how the recipient has used
the grant to meet the objectives described in subsection 
(b). 
(d) APPLICATIONS.—To seek a grant under this sec-
tion, an eligible academic health center shall submit an 
application to the Director in such manner, at such time, 
and containing such information and assurances as the 
Director may require. 
(e) AUTHORIZATION OF APPROPRIATIONS.—To carry 
out this section, there is authorized to be appropriated 
$125,000,000 for each of fiscal years 2006 through 2010. 
SEC. 6. DEMONSTRATION PROGRAM ON PARTNERSHIPS IN 
CLINICAL RESEARCH. 
(a) GRANTS.—The Secretary may make grants to not 
more than 5 eligible academic health centers to form part-
nerships between the center involved and health care pro-
viders for carrying out clinical human subject research for 
the purpose of demonstrating how academic research cen-
ters may collaborate with the practicing health care com-
munity in such research. 
(b) MAXIMUM AMOUNT.—The Secretary may not 
make a grant to any eligible academic health center under 
this section in an amount that is greater than $5,000,000. 
(c) APPLICATIONS.—To seek a grant under this sec-
tion, an eligible academic health center shall submit an 
application to the Director in such manner, at such time,
and containing such information and assurances as the 
Director may require. 
(d) AUTHORIZATION OF APPROPRIATIONS.—To carry 
out this section, there is authorized to be appropriated 
$25,000,000 for the period of fiscal years 2006 through 
2010. 
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