I 
117TH CONGRESS 
1ST SESSION H. R. 3085 
To amend the Public Health Service Act to improve the diversity of 
participants in research on Alzheimer’s disease, and for other purposes. 
IN THE HOUSE OF REPRESENTATIVES 
MAY 11, 2021 
Ms. BLUNT ROCHESTER (for herself, Ms. HERRERA BEUTLER, Mr. CURTIS, 
Mr. SMITH of New Jersey, and Ms. WATERS) introduced the following 
bill; which was referred to the Committee on Energy and Commerce 
A BILL 
To amend the Public Health Service Act to improve the 
diversity of participants in research on Alzheimer’s dis-
ease, and for other purposes. 
Be it enacted by the Senate and House of Representa-
tives of the United States of America in Congress assembled, 
SECTION 1. SHORT TITLE. 
This Act may be cited as the ‘‘Equity in Neuroscience 
and Alzheimer’s Clinical Trials Act of 2021’’ or the 
‘‘ENACT Act of 2021’’. 
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SEC. 2. INCENTIVES, IMPROVEMENTS, AND OUTREACH TO 
INCREASE DIVERSITY IN ALZHEIMER’S DIS-
EASE RESEARCH. 
(a) IMPROVING ACCESS
FOR
AND OUTREACH
TO 
UNDERREPRESENTED POPULATIONS.— 
(1) EXPANDING ACCESS TO ALZHEIMER’S RE-
SEARCH CENTERS.— 
(A) IN
GENERAL.—Section 445(a)(1) of 
the Public Health Service Act (42 U.S.C. 285e– 
2(a)(1)) is amended— 
(i) by striking ‘‘(a)(1) The Director of 
the Institute may’’ and inserting the fol-
lowing: 
‘‘(a)(1) The Director of the Institute— 
‘‘(A) may’’; 
(ii) by striking ‘‘disease.’’ and insert-
ing ‘‘disease; and’’; and 
(iii) by adding at the end the fol-
lowing: 
‘‘(B) beginning January 1, 2022, shall enter 
into cooperative agreements and make grants to 
public or private nonprofit entities under this sub-
section for the planning, establishment, and oper-
ation of new such centers that are located in areas 
with a higher concentration of minority groups (as 
determined under section 444(d)(3)(D)), such as en-
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tities that are historically Black colleges and univer-
sities, Hispanic-serving institutions, Tribal colleges 
and universities, or centers of excellence for other 
minority populations.’’. 
(B) USE OF FUNDING FOR CLINICS TO OP-
ERATE
CLINICAL
TRIALS.—Section 445(b) of 
the Public Health Service Act (42 U.S.C. 285e– 
2(b)) is amended by adding at the end the fol-
lowing: 
‘‘(3) Federal payments made under a cooperative 
agreement or grant under subsection (a) from funds made 
available under section 2(g) of the ENACT Act of 2021 
shall, with respect to Alzheimer’s disease, be used in part 
to establish and operate diagnostic and treatment clinics 
designed— 
‘‘(A) to meet the special needs of minority and 
rural populations and other underserved populations; 
and 
‘‘(B) to operate clinical trials’’. 
(2) OUTREACH.— 
(A) ALZHEIMER’S
DISEASE
CENTERS.— 
Section 445(b) of the Public Health Service Act 
(42 U.S.C. 285e–2(b)), as amended by para-
graph (1)(B), is further amended by adding at 
the end the following new paragraph: 
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‘‘(4) Federal payments made under a cooperative 
agreement or grant under subsection (a) shall be used to 
establish engagement centers to carry out public outreach, 
education efforts, and dissemination of information for 
members of minority groups about clinical trial participa-
tion. Activities funded pursuant to the preceding sentence 
shall include— 
‘‘(A) using established mechanisms to encour-
age members of minority groups to participate in 
clinical trials on Alzheimer’s disease; 
‘‘(B) expanding education efforts to make mem-
bers of minority groups aware of ongoing clinical 
trials; 
‘‘(C) working with trial sponsors to increase the 
number of recruitment events for members of minor-
ity groups; 
‘‘(D) conducting outreach to national, State, 
and local physician professional organizations, espe-
cially for members of such organizations who are 
primary care physicians or physicians who specialize 
in dementia, to increase awareness of clinical re-
search opportunities for members of minority 
groups; and 
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‘‘(E) using community-based participatory re-
search methodologies to engage with minority popu-
lations.’’. 
(B) RESOURCE
CENTERS
FOR
MINORITY 
AGING RESEARCH.—Section 444(c) of the Pub-
lic Health Service Act (42 U.S.C. 285e–1(c)) is 
amended— 
(i) by striking ‘‘(c)’’ and inserting 
‘‘(c)(1)’’ ; and 
(ii) by adding at the end the following 
new paragraph: 
‘‘(2) The Director, acting through the Resource Cen-
ters for Minority Aging Research of the Institute, shall 
carry out public outreach, education efforts, and dissemi-
nation of information for members of minority groups 
about participation in clinical research on Alzheimer’s dis-
ease carried out or supported under this subpart.’’. 
(b) INCENTIVES TO INCREASE DIVERSITY IN ALZ-
HEIMER’S DISEASE RESEARCH THROUGH PRINCIPAL IN-
VESTIGATORS
AND
RESEARCHERS
FROM
UNDERREP-
RESENTED POPULATIONS.— 
(1) ALZHEIMER’S
CLINICAL
RESEARCH
AND 
TRAINING
AWARDS.—Section 445I of the Public 
Health Service Act (42 U.S.C. 285e–10a) is amend-
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ed by adding at the end the following new sub-
section: 
‘‘(d) ENHANCING THE PARTICIPATION OF PRINCIPAL 
INVESTIGATORS AND RESEARCHERS WHO ARE MEMBERS 
OF UNDERREPRESENTED POPULATIONS.— 
‘‘(1) IN GENERAL.—The Director shall enhance 
diversity in the conduct or support of clinical re-
search on Alzheimer’s disease under this subpart by 
encouraging the participation of individuals from 
groups that are underrepresented in the biomedical, 
clinical, behavioral, and social sciences as principal 
investigators of such clinical research, as researchers 
for such clinical research, or both. 
‘‘(2) TRAINING
FOR
PRINCIPAL
INVESTIGA-
TORS.—The Director of the Institute shall provide 
training for principal investigators who are members 
of a minority group with respect to skills for— 
‘‘(A) the design and conduct of clinical re-
search and clinical protocols; 
‘‘(B) applying for grants for clinical re-
search; and 
‘‘(C) such other areas as the Director de-
termines to be appropriate.’’. 
(2) SENIOR
RESEARCHER
AWARDS.—Section 
445B(a) of the Public Health Service Act (42 
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