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(E) in section 409E, by striking subsection 
(d); 
(F) in section 417C, by striking subsection 
(f); 
(G) in section 424B(a)— 
(i) in paragraph (1), by adding ‘‘and’’ 
after the semicolon at the end; 
(ii) in paragraph (2), by striking ‘‘; 
and’’ and inserting a period; and 
(iii) by striking paragraph (3); 
(H) in section 429, by striking subsections 
(c) and (d); 
(I) in section 442, by striking subsection 
(j) and redesignating subsection (k) as sub-
section (j); 
(J) in section 464D, by striking subsection 
(j); 
(K) in section 464E, by striking subsection 
(e); 
(L) in section 464T, by striking subsection 
(e); 
(M) in section 481A, by striking subsection 
(h); 
(N) in section 485E, by striking subsection 
(k); 
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(O) in section 485H— 
(i) by striking ‘‘(a)’’ and all that fol-
lows through ‘‘The Secretary,’’ and insert-
ing ‘‘The Secretary,’’; and 
(ii) by striking subsection (b); and 
(P) in section 494— 
(i) by striking ‘‘(a) If the Secretary’’ 
and inserting ‘‘If the Secretary’’; and 
(ii) by striking subsection (b). 
(2) PUBLIC HEALTH SERVICE ACT; OTHER PRO-
VISIONS.—The Public Health Service Act (42 U.S.C. 
201 et seq.) is amended— 
(A) in section 399E, by striking subsection 
(e); 
(B) in section 1122— 
(i) by striking ‘‘(a) From the sums’’ 
and inserting ‘‘From the sums’’; and 
(ii) by striking subsections (b) and 
(c); 
(C) by striking section 2301; 
(D) in section 2354, by striking subsection 
(b) and redesignating subsection (c) as sub-
section (b); 
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(E) in section 2356, by striking subsection 
(e) and redesignating subsections (f) and (g) as 
subsections (e) and (f), respectively; and 
(F) in section 2359(b)— 
(i) by striking paragraph (2); 
(ii) by striking ‘‘(b) EVALUATION AND 
REPORT’’ and all that follows through 
‘‘Not later than 5 years’’ and inserting 
‘‘(b) EVALUATION.—Not later than 5 
years’’; 
(iii) by redesignating subparagraphs 
(A) through (C) as paragraphs (1) through 
(3), respectively; and 
(iv) by moving each of paragraphs (1) 
through (3) (as so redesignated) 2 ems to 
the left. 
(3) OTHER ACTS.—Provisions of Federal law 
are amended as follows: 
(A) Section 7 of Public Law 97–414 is 
amended— 
(i) in subsection (a)— 
(I) in paragraph (2), by inserting 
‘‘and’’ at the end; 
(II) in paragraph (3), by striking 
‘‘; and’’ and inserting a period; and 
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(III) by striking paragraph (4); 
and 
(ii) in subsection (b), by striking the 
last sentence of paragraph (3). 
(B) Title III of Public Law 101–557 (42 
U.S.C. 242q et seq.) is amended by striking 
section 304 and redesignating section 305 and 
306 as sections 304 and 305, respectively. 
(C) Section 4923 of Public Law 105–33 is 
amended by striking subsection (b). 
(D) Public Law 106–310 is amended by 
striking section 105. 
(E) Section 1004 of Public Law 106–310 
is amended by striking subsection (d). 
(F) Section 3633 of Public Law 106–310 
(as amended by section 2502 of Public Law 
107–273) is repealed. 
(G) Public Law 106–525 is amended by 
striking section 105. 
(H) Public Law 107–84 is amended by 
striking section 6. 
(I) Public Law 108–427 is amended by 
striking section 3 and redesignating sections 4 
and 5 as sections 3 and 4, respectively. 
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SEC. 6. CERTAIN DEMONSTRATION PROJECTS. 
(a) BRIDGING THE SCIENCES.— 
(1) IN GENERAL.—From amounts to be appro-
priated under section 402A(b) of the Public Health 
Service Act, the Secretary of Health and Human 
Services, acting through the Director of NIH, (in 
this subsection referred to as the ‘‘Secretary’’) in 
consultation with the Director of the National 
Science Foundation, the Secretary of Energy, and 
other agency heads when necessary, may allocate 
funds for the national research institutes and na-
tional centers to make grants for the purpose of im-
proving the public health through demonstration 
projects for biomedical research at the interface be-
tween the biological, behavioral, and social sciences 
and the physical, chemical, mathematical, and com-
putational sciences. 
(2) GOALS, PRIORITIES, AND METHODS; INTER-
AGENCY COLLABORATION.—The Secretary shall es-
tablish goals, priorities, and methods of evaluation 
for research under paragraph (1), and shall provide 
for interagency collaboration with respect to such re-
search. In developing such goals, priorities, and 
methods, the Secretary shall ensure that— 
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(A) the research reflects the vision of inno-
vation and higher risk with long-term payoffs; 
and 
(B) the research includes a wide spectrum 
of projects, funded at various levels, with vary-
ing timeframes. 
(3) PEER
REVIEW.—A grant may be made 
under paragraph (1) only if the application for the 
grant has undergone technical and scientific peer re-
view under section 492 of the Public Health Service 
Act (42 U.S.C. 289a) and has been reviewed by the 
advisory council under section 402(k) of such Act 
(as added by section 3(c) of this Act) or has been 
reviewed by an advisory council composed of rep-
resentatives from appropriate scientific disciplines 
who can fully evaluate the applicant. 
(b) HIGH-RISK, HIGH-REWARD RESEARCH.— 
(1) IN GENERAL.—From amounts to be appro-
priated under section 402A(b) of the Public Health 
Service Act, the Director of NIH may allocate funds 
for the national research institutes and national cen-
ters to make awards of grants or contracts or to en-
gage in other transactions for demonstration 
projects for high-impact, cutting-edge research that 
fosters scientific creativity and increases funda-
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mental biological understanding leading to the pre-
vention, diagnosis, and treatment of diseases and 
disorders. The head of a national research institute 
or national center may conduct or support such 
high-impact, cutting-edge research (with funds allo-
cated under the preceding sentence or otherwise 
available for such purpose) if the institute or center 
gives notice to the Director of NIH beforehand and 
submits a report to the Director of NIH on an an-
nual basis on the activities of the institute or center 
relating to such research. 
(2) SPECIAL CONSIDERATION.—In carrying out 
the program under paragraph (1), the Director of 
NIH shall give special consideration to coordinating 
activities with national research institutes whose 
budgets are substantial relative to a majority of the 
other institutes. 
(3) ADMINISTRATION OF PROGRAM.—Activities 
relating to research described in paragraph (1) shall 
be designed by the Director of NIH or the head of 
a national research institute or national center, as 
applicable, to enable such research to be carried out 
with maximum flexibility and speed. 
(4) PUBLIC-PRIVATE PARTNERSHIPS.—In pro-
viding for research described in paragraph (1), the 
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Director of NIH or the head of a national research 
institute or national center, as applicable, shall seek 
to facilitate partnerships between public and private 
entities and shall coordinate with the Foundation for 
the National Institutes of Health. 
(5) PEER REVIEW.—A grant for research de-
scribed in paragraph (1) may be made only if the 
application for the grant has undergone technical 
and scientific peer review under section 492 of the 
Public Health Service Act (42 U.S.C. 289a) and has 
been reviewed by the advisory council under section 
402(k) of such Act (as added by section 3(c) of this 
Act). 
(c) REPORT TO CONGRESS.—Not later than the end 
of fiscal year 2009, the Director of NIH shall conduct an 
evaluation of the activities under this section and submit 
a report to the Congress on the results of such evaluation. 
(d) DEFINITIONS.—For purposes of this section, the 
terms ‘‘Director of NIH’’, ‘‘national research institute’’, 
and ‘‘national center’’ have the meanings given such term 
in section 401 of the Public Health Service Act. 
SEC. 7. FOUNDATION FOR THE NATIONAL INSTITUTES OF 
HEALTH. 
Section 499 of the Public Health Service Act (42 
U.S.C. 290b) is amended— 
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(1) in subsection (d)— 
(A) in paragraph (1)— 
(i) by amending subparagraph (D)(ii) 
to read as follows: 
‘‘(ii) Upon the appointment of the ap-
pointed members of the Board under 
clause (i)(II), the terms of service as mem-
bers of the Board of the ex officio mem-
bers of the Board described in clauses (i) 
and (ii) of subparagraph (B) shall termi-
nate. The ex officio members of the Board 
described in clauses (iii) and (iv) of sub-
paragraph (B) shall continue to serve as ex 
officio members of the Board.’’; and 
(iii) in subparagraph (G), by inserting 
‘‘appointed’’ after ‘‘that the number of’’; 
(B) by amending paragraph (3)(B) to read 
as follows: 
‘‘(B) Any vacancy in the membership of 
the appointed members of the Board shall be 
filled in accordance with the bylaws of the 
Foundation established in accordance with 
paragraph (6), and shall not affect the power of 
the remaining appointed members to execute 
the duties of the Board.’’; and 
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(C) in paragraph (5), by inserting ‘‘ap-
pointed’’ after ‘‘majority of the’’; 
(2) in subsection (j)— 
(A) 
in 
paragraph 
(2), 
by 
striking 
‘‘(d)(2)(B)(i)(II)’’ and inserting ‘‘(d)(6)’’; 
(B) in paragraph (4)— 
(i) in subparagraph (A), by inserting 
‘‘, including an accounting of the use of 
amounts transferred under subsection (l)’’ 
before the period at the end; and 
(ii) by striking subparagraph (C) and 
inserting the following: 
‘‘(C) The Foundation shall make copies of 
each report submitted under subparagraph (A) 
available— 
‘‘(i) for public inspection, and shall 
upon request provide a copy of the report 
to any individual for a charge that shall 
not exceed the cost of providing the copy; 
and 
‘‘(ii) to the appropriate committees of 
Congress.’’; and 
(C) in paragraph (10), by striking ‘‘of 
Health.’’ and inserting ‘‘of Health and the Na-
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tional Institutes of Health may accept transfers 
of funds from the Foundation.’’; and 
(3) by striking subsection (l) and inserting the 
following: 
‘‘(l) FUNDING.—From amounts appropriated to the 
National Institutes of Health, for each fiscal year, the Di-
rector of NIH shall transfer not less than $500,000 and 
not more than $1,250,000 to the Foundation.’’. 
SEC. 8. APPLICABILITY. 
This Act and the amendments made by this Act apply 
only with respect to amounts appropriated for fiscal year 
2007 or subsequent fiscal years. 
Passed the House of Representatives September 26, 
2006. 
Attest: 
KAREN L. HAAS, 
Clerk. 
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