(2) inserting after section 404G the following 
new section: 
‘‘SEC. 404H. OFFICE OF MITOCHONDRIAL MEDICINE. 
‘‘(a) ESTABLISHMENT.—There is established within 
the Office of the Director of NIH an office to be known 
as the Office of Mitochondrial Medicine (in this section 
referred to as the ‘Office’), which shall be headed by a 
Director (in this section referred to as the ‘Director’), ap-
pointed by the Director of NIH. 
‘‘(b) 
MITOCHONDRIAL
MEDICINE
RESEARCH 
PLAN.— 
‘‘(1) IN GENERAL.—The Director shall develop, 
make publicly available, and implement a written 
plan to facilitate research into mitochondrial medi-
cine. 
‘‘(2) CONTENTS.—The plan required under 
paragraph (1) shall include the following objectives: 
‘‘(A) Improving coordination of research 
related to mitochondrial medicine among the 
national research institutes and between the 
National Institutes of Health and outside re-
searchers. 
‘‘(B) Providing training to research sci-
entists and health professionals engaged in re-
search related to mitochondrial medicine. 
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‘‘(C) Providing training to health care pro-
viders regarding the diagnosis of mitochondrial 
disease and dysfunction. 
‘‘(D) Establishing scientific review groups 
with expertise in mitochondrial medicine to 
oversee relevant research projects in the Na-
tional Institutes of Health. 
‘‘(3) CONSULTATION.—In developing the plan 
under paragraph (1), the Director shall consult 
with— 
‘‘(A) the Director of the National Cancer 
Institute; 
‘‘(B) the Director of the National Institute 
of Child Health and Human Development; 
‘‘(C) the Director of the National Institute 
of Environmental Health Sciences; 
‘‘(D) the Director of the National Heart, 
Lung, and Blood Institute; 
‘‘(E) the Director of the National Institute 
of Neurological Disorders and Stroke; 
‘‘(F) the Director of the National Institute 
of Diabetes and Digestive and Kidney Diseases; 
‘‘(G) the Director of the National Eye In-
stitute; and 
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‘‘(H) the heads of such other institutes 
and offices as the Director considers appro-
priate. 
‘‘(4) UPDATES.—The Director shall update the 
plan required under paragraph (1) on a biennial 
basis. 
‘‘(c) RESEARCH GRANTS.—In addition to any grants 
otherwise awarded by the National Institutes of Health 
for research in mitochondrial medicine, the Director shall 
annually award— 
‘‘(1) at least five grants for integrated, multi- 
project research programs related to mitochondrial 
medicine; and 
‘‘(2) at least five grants for planning activities 
associated with integrated, multi-project research 
programs related to mitochondrial medicine. 
‘‘(d) CENTERS OF EXCELLENCE.— 
‘‘(1) IN GENERAL.—The Director may award 
grants to institutions or consortiums of institutions 
to establish Mitochondrial Medicine Centers of Ex-
cellence to promote interdisciplinary research and 
training related to mitochondrial medicine. 
‘‘(2) USE
OF
FUNDS
AWARDED.—A grant 
awarded under paragraph (1) shall be used to— 
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‘‘(A) conduct basic and clinical research re-
lated to mitochondrial medicine; 
‘‘(B) facilitate training programs for re-
search scientists and health professionals seek-
ing 
to 
engage 
in 
research 
related 
to 
mitochondrial medicine; 
‘‘(C) develop and disseminate programs 
and materials to provide continuing education 
to health care professionals regarding the rec-
ognition, 
diagnosis, 
and 
treatment 
of 
mitochondrial disease and dysfunction; and 
‘‘(D) provide living stipends for research 
scientists and health professionals enrolled in 
mitochondrial research training programs. 
‘‘(e) NATIONAL REGISTRY; BIOREPOSITORY.— 
‘‘(1) NATIONAL REGISTRY.—The Director shall 
establish a national registry for the maintenance and 
sharing for research purposes of medical information 
collected from patients with mitochondrial disease or 
dysfunction. 
‘‘(2) BIOREPOSITORY.—The Director shall es-
tablish a national biorepository for the maintenance 
and sharing for research purposes of tissues and 
DNA collected from patients with mitochondrial dis-
ease or dysfunction. 
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‘‘(f) 
DEFINITION.—In 
this 
section, 
the 
term 
‘mitochondrial medicine’ means medical treatment related 
to mitochondrial disease or dysfunction.’’. 
(b) DEVELOPMENT OF MITOCHONDRIAL MEDICINE 
RESEARCH
PLAN.—The Director of the Office of 
Mitochondrial Medicine shall develop and make publicly 
available the mitochondrial medicine research plan re-
quired under section 404H(b)(1) of the Public Health 
Service Act, as added by subsection (a) of this section, 
not later than 180 days after the date of the enactment 
of this Act. 
Æ 
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