include che membrane vransport bab ea EPeRR | g 607 ‘ 3) 4980 OSteFane connes_ vaons, Approved: erRetease: 2 0108/08: h PPS AY ‘SYOVS TEGO positions 6f tne membranes the transmission of vibrations from one of the communicating membranes to whe other; this process would be affected not only by the tyne of contact but by the dts_ tribution of she fields as well. Judging by the morphological descriptions of temporary changes in the cells exposed to unfavorable impacts, the_ so-called endoplasmatic network (a system of interlinked de_ formed membrane elements) and deformations of this network can be an important factor in controlling the processes aimed at becovering normal vital functions. A detailed description of the processes is still beyond the grasp of investigators, out their vital importance for the cell and the Organism is unquestionable. In short, the features and regularities of the functioning of: microwave devices, wher applied to studies of the effects of electromagnetic vibrations on control processes in - live Organisms, can shed light on at least some of these processes. In particular, ther provide a better understanding of the following: - the influence of the oscillation frequency on these processes (the role of reso= nances in the form of oscillations induced in the membranes); - the limited influence of further increases of the EMR power on these processes (since they occur as Synchronization of membrane oscillations rather than by power im- pacts on cellular processes) once the Power is above a certain threshold; - the reasons for the pronounced effectiveness of radiation in organisms with dis- rupted function (which develop structures to connect membrane oscillations with external radiation); and - the need for long-term irradiation to obtain a residual biological effect (this concerns restructuring in the cells, which consumes energy and requires material to be brought to the site of action in the course of metabolic processes). A single study can make only a limited contribution to understanding these exceedingly complex and little-~investigated processes, which emphasizes the importance of continuing this research, . “REFERENCES Ll. WN. D. Devyatkov, M. B, Golant, and T. B, Rebrova, "Radioelectronics and medicine (the possible uses of analogies)," Izv. VUuZ. Radioelektronika®, vol. 25, no. 9, pp. 3-8, 1 co uf . 2a. Ne Dz Devyatkov, "The influence of electromagnetic radiation in the millimeter wave band on biological objects," Uspekhi Fiz. Nauk, vol. 110, no. 3, PP. 453-454, 1973. - N. D. Devyatkov, E. A. Gelvich, and M. B, Golant, et al., "Radiophysical aspects of medical applications of energy and information effects of electromagnetic vibrations," Elektron, Tekhnika, Ser. Elektronika SVCh, no. 9 (333), pp. 43-50, 1981. 4. N. D, Devyatkovy and M. B. Golant, "The informational nature of nonthermal and energy effects of electromagnetic vibrations in a live organism," Pis'ma v Zh. Tekhn. Fiz., vol. 8, no. 1, PP. 39—41, 5. A. K, Bryukhova, M. B. Golant, and T. B. Rebrova, "Reproducibility of experimen- tal results in Studies of the effects of electromagnetic radiation of a nonthermal in- tensity in the Millimeter wave band as affecting live organisms," Elektron. Tekhnika, Ser. Elektronika SVCh, no, 8, pp. 52-57, 1985, oo . 6. H. Frolich, "The biological effects of microwaves and related questions," Ad- vances in Electronics and Electron Physics, vol. ll, pp. 85-132, 1983. 7. ON. Dd. Devyatkov, M. B. Golant, and A, 8S, Tager, "The role of Synehronization in the effects of weak millimeter wave band electromagnetic signals on live organisms," Bio- fizgika, vol. 28, no. 355 PP. 895-896, 1983, 8 RL, Vilenskaya, E. A. Gelvich, and M, B. Golant, et al., "The nature of the ine fluence of millimeter radiation on colicin Synthesis," Nauchnye Doklady Yysshei Shkoly, Blologichesktie Nauki, no. 7, pp. 69-71, 1972. *Radioelectronics and Communications Systems. Available from Allerton Press, Inc., 150 Fifth Ave., New York, N. Y, 10011; (212) 924-3950, 14 Approved For Release 2000/08/08 : CIA-RDP96-00789R003100280001-7
Approved For Release 2000/08/08 : CIA-RDP96-00789R003100280001-7 9. "Promising research and methods for medicine and biology," Elektronnaya Promysh- lennost, no. 1 (139), pp. 6-13, 1985. 19. =. tl. Balibalova, A. G. Borodkina, and M. B. Golant, et al., "Amplitude modulation used to improve the efficacy of equipment utilized for informational influence of electro- magnetic vepravions on live organisms,". Elektron. Tekhnika, Ser..Elektronika SVCh, no. 8 ll. Me. B. Golant and V. A. Shashlov, "The mechanism of vibrations induced in cell membranes by weak electromagnetic fields," in: Applications of Electromagnetic Low-Inten- sity Radiation in Biology and Medicine {in Russian], N. D. Devyatkova (Editor), IRE AN SSSR, lMoscow, pp. 127-132, 1985. ~ 12. W. Grundler and F. Keilmann, "Sharp resonances in yeast growth prove nonthermal sensitivity to microwaves," Physical Review Let., vol. 51, no. 13, pp. 1214-1216, 1983. 13. L. A. Sevasttyanova, A. G. Borodkina, E. S$. Zubenkova, et al., "Resonance na- sure of the millimeter radiowave effects on biological systems," in: Nonthermal Effects or oot Radiation on Biological Objects [in Russian], IRE AN SSSR, Moscow, pp. 34— 14, V. G. Ivkov and G. N. Berestovskii, Lipid Bilayer of Biological Membranes cin Russian], Nauka, Moscow, 1982. G. Stant and R. Calindar, Molecular Genetics [Russian translation], Mir, Moscow, 1 1981. : 16. LL. D. Bergel'son, Membranes, Molecules, Celis [in Russian], Nauka, Moscow, 1982. 17. M. B. Golant, A. K. Bryukhova, and E. A. Dvadtsatova, et al., "The possibility of regulating the vital activities of microorganisms exposed to electromagnetic vibrations in the millimeter band," Applications of Electromagnetic Low-Intensity Radiation in Biology and Medicine [in Russian], N. D. Devyatkov (Editor), IRE AN SSSR, Moscow, pp. 115-122, 1983. _— 18. S. J. Webb, "Nutrition, coherent oscillations, and solitary waves: The control of in vivo events in time and space and its relationship to disease," IRCS Med. Sci., vol. ll, pp. 483-488, 1983. mo 19. I. V. Lebedev, Microwave Technology and Devices [in Russian], Vysshaya Shkola, vol. 2, 1972. , . 20. ge. 3. Sotnikov, Structural Dynamics of a Live Neuron [in Russian], Nauka, Lenin- grad, 1985. se 21. S. Roulands, "Coherent excitations in blood," in: Coherent Excitations in Biologi- cal Systems, Springer Verlag, Berlin-Heidelberg, pp. 145-161, 1983. ~~ 22. N. D. Devyatkov and M. B. Golant, "The mechanisms of action of millimeter-band electromagnetic radiation of nonthermal intensity on the vital activities of organisms," in: Applications of Electromagnetic Low-Intensity Radiation in Blology and Medicine [in Russian], N. D. Devyatkov (Editor), IRE AN SSSR, Moscow, pp. 18-33, 1983. 23. E. Del Giudice, E. Doglia, and M. Milani, "Self-focusing and ponderomotive forces of coherent electric waves: A mechanism for cytoskeleton formation and dynamics," in: Coherent Excitations in Biological Systems, Springer-Verlag, Berlin-Heidelberg, pp. 123- 127, 1983. ; t 13 January 1986 Approved For Release 2000/08/08 : CIA-RDP96-00789R003100280001-7
Approved For Release 2000/08/08 : CIA-RDP96-00789R003100280001-7 RADIOELECTRONICS AND MEDICINE (ON SCOPE FOR USING CERTAIN ANALOGIES) N. D. Devyatkov, M. B. Golant, and T. B. Rebrova . = Izvestiya VUZ. Radioelektronika, Vol. 25, No. 9, pp. 3-8, 1982 UDC 621.38:61 Large radio-electronic systems and living organisms are both complex systems (albeit of very different degrees of complexity), and a great role is played by informational aspects in ensuring their long-term uninterrupted operation. — Since radio-electronic systems are incomparably simpler than living organisms, the ways of studying them and ensuring their reliable operation are vastly simp- ler. It is suggested that, on the basis of analogies, the approach to the solu- tion of medical-biological problems can in certain cases be simplified. , With the wide use of radio-electronics and cybernetics it has become possible to cre- ate a new apparatus playing a revolutionary role in modern medicine and biology. The range of application of the new apparatus is so vast that it can scarcely be surveyed in a single article. Nevertheless, there ts one link between these sciences that is only just start- ing to be developed, though it may well prove very fruitful in the future. We are speak- ing of the possibility. of using in medicine and biology certain general ideas of electronics and cybernetics, and on the basis of analogies, devising new approaches to the solution of medical-biological problems. But let us emphasize at the outset that only a few aspects of this vast and many-sided topic can be mentioned here. " Radio-electronics is concerned at present with devising complex multielement systems suitable for long-term uninterrupted operation in varying external conditions. Living or- ganisms (primarily men) are likewise complex systems (though much more complex), often with a very long life. This means from the physical point of view that the ordering and organi- gation of the systems have to be preserved or restored while in contact with the external medium, and that their entropy (a measure of their lack of order) has to increase extremely slowly [1]. We need to eonsider the main conditions for long-term preservation of the ordering of a large system. In principle, the following conditions refer, not only to electronic systems and living organisms, but also to any large stably operating systems, such as e.g., undertakings with external connections:. ~ . a) we need a material and energy supply from outside for the system, to make good its energy consumption and to replace elements that have ceased to perform their function; b) we need reserves such that, on the one hand, partially failed elements can be kept at the operating leyel needed for maintaining operation of the system as a whole, and on the other hand, so that reserves of certain elements can be mobilized in order to compen- sate for poor operation of others; e) we need circuits for obtaining and transmitting data about all variations inside and outside the system, so that the system can adequately respond to these variations; d) we need central and peripheral control circuits, and automatic feedback loops for controlling the system response to internal and external variations; e) we need a sensitive display whereby processes unfavorable to the system can be de- tected in their early development stage and the data obtained used for adjusting the system, so as either to stop the further development of these processes or to prepare the system for operation in the new conditions. . , . - The approach to the living organism as a unified, data-connected and data-controlled system, implies the first importance of data aspects when solving medical and biological problems. While this is obvious in principle, the ways of going over from general ideas © 1882 by Alle PPLOMed For Release 2000/08/08 : CIA-RDP96-00789R003100280001 -7 1
to pract#pprowvechhoan Release 200.M0808 -GIAFRDP2800789R003.100280001 they are, comparatively speaking, in electronics: many unsolved or only partially solved problems Still need to be studied. We need to know how the data systems of the organism operate, what sort of scope they have, and how medical interference can assist the operation of the data systems, etc, _ To the extent to which the data signals in the organism are electrical (The data System is not solely concerned with electrical signals. In particular, an important role is played by data transmission by humoral agents. But we shall only deal here with elec- tromagnetic oscillations.) and the problems concern the "electronic”™ properties of the living organism, the ways of Studying the problems must also be “electronic,” i.e., they must involve a study of spectral characteristics, and of nonlinear and modulation proper- ties etc. An important step forward was made in [2] with the proof (based on analysis of a) weak dependence of biological effects of external (radiation-connected) data sig-. nals on the EMO power flux, starting from a (usually extremely low threshold level and going up to levels at which effects connected with heating of the irradiated object start to have an important role; b) the sharply resonant response of living organisms to low-power EMO radiation (We are only speaking here of signal frequencies at which the energy of the quanta is insuffi- cient for disrupting the molecular bonds.); the relative frequency bandwidth in which a re— Sponse is seen usually does not exceed tenths of one percent; often a number of mutually displaced bands is observed, in which the biological object has a similar response.’ The nature of these laws has been discussed in various Russian and foreign publica- tions, e.g., [3, 4, 5].. In particular, 1t was suggested in [3, 5], on the basis of a com parison with technical cybernetic systems, that. the first law is linked.with the informa- tional nature of the weak EMO Signal action on the living organism and is determined by. the reliability of operation of the organism data system. : ; On the other hand, information on the State and operation of. the different organs and systems of the organism is contained in the spectrum of the Signals generated hy the or- ganism; to each variation of the State or type of activity there correspond specific spec- trum variations. The spectrum extends from very low to ( let frequencies [11]. A Special role is played by the lines in the infrared part of the spectrum, i.e., in the vicinity of the maximum of thermal radiation at the organism tem- perature. This is confirmed by the determination and analysis of Raman spectra [6, 7] of living organisms, which include a number of pronounced lines in the infrared part, and also their harmonics and combination frequencies. In [4], the author summarizes many years of theoretical study, and gives a detailed justification of the hypothesis that the direct action of low-power: EMO on the living organism is linked with collective excitations of certain structural elements of the organism (Both the author of [4] and many other foreign or Russian authors assign a big role in the perception of excitations to cellular mem- branes.); the quasi-particles characterizing these excitations behave like Bosons, i.e., are subject to Bose statistics, The threshold power needed for response to irradiation 1s determined hy the transi- tion from excitation of noise oscillations to excitation of coherent high-amplitude oscilla— tions at a mode of collective excitation. The presence of this kind of excitation remote _ from absolute zero [8] in the living organism becomes possible as a result of material ex- change and energy transformation, whereby, in the neighborhood of certain frequencies, energy loss in the data transmission system and data signal processing system can be com- pensated. But, as was earlier pointed out in [1], in conditions of compensation of energy loss by the source, any System can behave like a system operating in the neighborhood of absolute zero. Notice also, see [9], where action of frequency-modulated low power EMO Signals on the living organism was studied, that the frequencies at which a. response to weak signal radia- tion is seen, can differ Slightly (by approx. 0.001 of the basic frequency) according to the irradiated part of the body. It was also shown that the bandwidth (likewise 0.001 of the basic frequency) in which’ the organism responds to Irradiation, is determined by the presence of several oscillators with displaced frequencies, and hence low-amplitude fre- _ quency modulated irradiation can lead to some increase in the organism response. , These and other experimental and theoretical studies have Somewhat clarified the ways possible for medical interference in the operation of the data systems of an organism. The . 2 | Approved For Release 2000/08/08 : CIA-RDP96-00789R003100280001-7