M. B. Golant
t:
and cbmmr °f the influm« ° f ,ou
herent low intensity radiations of the vibriii'
* ” ”
'" , ed Wlth s>'nchr°n'2ation by co
tion is linked the LZhcZ of these 27T"
" ,he “U ' With sy^™iza-
herent summing of tbe^bradons pre^otMly^ep^s^or^ah
tbC C°"
of the intracelluJar sources and
thf*
P
°r excited at different frequencies
capable of orienting in adefudte way or reorienting
si^
reference [25] it was assumed that
for the established whTeb^Xa^^
iS “? “•'
S° UrCC
question of the transfnrmnfinnr>r
j
ut merely synchronizes them. The
rent vibradot
“ST
“H™"**"
1-
this question.
ater sect| ons
is concerned with
Excitation ofthe vibrations ofprotein molecules in the cell ThAm.kr
>, a a
.
in reference HI n»fArr.n«
•
.
<« me cell, rue published data outlined
rexerence HJ referring to experimental studies indicate that the I.Vina
nomous system is controlled hv e h r
*;
i
muicaie tnat the living cell as an auto
in this process is
"
,
, 2
® a‘S 8M'ratcd by <•* cell itself. A major role
lems of StationTv"h 7
*
by 'hc pcotcin molecules. In the literature the prob-
fully both experimentally aZXZSrally”
"’‘’‘““k5 h8V' bee" “plored reasonab,y
rec,™o7D!dtt'l?
erimTd
t2«°J ««= undertaken under the di-
hy
he mefhS rf ZV
P
y
ened appara*”s Pccidhhng use of spectra obtained
vLomm^memen^
T™T™'*
sP“trorcopy. ™e appaTtus permitted
lie hTmorr
,
“"d,,,0"s <*
irradiation both of crystalline and lyophyl-
the
“cl“ii"? n,eas“rcments in a strong magnetic held ensLd by
lhtrSl
,‘ b
Wf
Cha"8e in the ttmp'ral“re »ftb' samples from
probably apply mnr
°
° 'y85 ^ ^ Pro[c ‘n' although the results of measurement
L^7„?he LZouS
y
',
,
0Wn by tbe measurements, e.h.f. exerts a resonance
the width of the reson
"
h*
10^° ^ expressed in changes
>’& the Mossbauer spectrum:
room iemperature is only 3 MHz. Several series of
Didenko concluded th
°
i, e™™
amUysis of the chan8« in the Mossbauer spectra
co^Za “mfe ;
““ haemoglobin molecules pass .0 new
the ei«™cS arad .n T
‘“Stribuli°" °f charge of the electrons and by
ture L rZrtaolZ f
"s
“ re!0"““ ft‘1>“"cicr the tertian, strnc
ThesZ
hf V
‘‘I
’
J^ °f the molKu1' and
dynamic properties change.
in the re“m period A
Ve a,S° formed ,he “««* of numerous theoretical investigations
I
.
.
.. ng them we would note the work of Frauenfelder el ai [31-33]
fv
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roved For Release 2000/08/08
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aediumin
ng to theif
each
Resonance
effect of coherent electromagnetic radiations
s from the foi
„ho developed the model of the dynamic behaviour of proteina accotding to which the
noleculee perform
fluctuations
passing from one conformational
stTe
,o Tnoto
many of these states being energetically very close to each other. At reduced temnem’
tares (nitrogen level and even lower) the probability of such transitions assocteTwhh
overcoming the potential Harriets
falls in proportion
exp
X “
isle
eaetgy of the transitton [34J. At room temperature most of the suLtLll„
!
egui lbrium. The conformational mobility is important for the fulfilment by thelo
molecules of their biological function. Accordingly thermal equilibrium!* to a cl
atm averaged distribution of these functions between the molecules.
The e.h.f signal is capable of synchronizing the vibrations isolating certain conform*
nonal states m those moiecules with .esonance frequencies close to theCue °J o The'
synchronizing signal. The possibility of excitation of
•
requency of the
r * «"
isdetm“^^
molecules are distributed in them unevenly so that th***
,
i
i
P
l
* °f the protem
dipole moments P5J. In line with the model of hiomacromoSS deve'loplllrf'
erence [36] at different frequencies the e.h.f. field interacts with th^.v h o-
P
feP
Particularly effective interaction ofthee.hf field with protein molec
l
'
erent portlons -
to the membranes where the e.h.f. waves are retarded and their
scoustic (see preceding section) the length of which is commensurate ih the size
the
protein molecule. As made clear above, on exposure to an e.h.f. signal the proZ 1,«
rules are drawn to the membrane surface, the character of the proSss of draw „» ,7,1
inner surface of the membrane being similar to that of molecules to its outer surface (231
As a result information structures may form on the membrane surface (an extmnle of
one of them was given in reference [1]).
1 "
xample of
Didenlco relates the results obtained by her in study of the action of an e h f
sicnal
on the Mossbauer spectra of protein molecules to excitation in the latter at the resoZce
frequences of acoustic vibrations. The quality factor of the haemoglobin molecuZal
acoustic resonators Q„ according to the evaluation made by her (on The basiTof rh7,„f
logy with polymers is quite large: ~ 10*. The magnitude hfo
>s brand m3
J
molecules the effects of accumulation of the enftgy
intone to isolate the action of even very weak coherent signals against the background
Mechanism of generation by the cells of coherent e.h.f signals. The material of
previous sections allows us to pass to an exposition of ideas on the mechan^m" of^Jo
generation of e h.f. vibrations in the cell [5], This is a very important question since as
r.ady noted the action of the external signals on the cells
is effective only to the extent
it imitates their autovibrations.
y
tent
Probably it is rational to outline as follows the sequence of the process of excitation
of the automations. In conditions when as a result of certain actions on the cell lead-
ing o anomalies m its functioning its symmetry
is disturbed, conditions of preflntial
excitation are created in the cell membranes at certain resonance frequencies (see ^0^
This leads to synchronization of the vibrations of those protein molecules adheriTm
e membrane and the resonance frequencies of which coincide or are close to the fre-
w
I
Approved For Release 2000/08
* W^u
M. B. Golant
preferential transfer?,
reSton”8 the e1“ihT>rium slamt" ^
Ctgy “cha"8e >*•
utembranes ZTZ /^™“ ,he ”°'ecuies sytotSd ET* “ ,intad *«> -h«
a. theCLS n/tlfv?
0"
‘“ **
Centf>? J*"*- <* >he
Of the cell is ensured hv, n-
ratlons of other molecules Maimers
re intense than that
I» <he initial period afterdhtf
r
?mova* “fenergy ofmetabolism ”n?t?
t™P'r“r'
eration of coherent ?!,
,
dlslurba"c=of
ithe symmetry of the ,?
I”“,tl,e external space.
W is reia^Tow alZL?
“ * S'°'
SiS
I
The nmn
,
.
“Violations generated by the cells)
I
quires^
s^a^
^Snmol^ I
restriction
rg
fph
XPendltUre exPonent«aJIy growing withd^*™”
°n ^ membranes
re ‘ 9
~
f
att3inab,e *""*
‘be vibration!
e
, ^ This inevitabJy »«ds to
it produces H7 t
°f dlsturbances and the greater the
° P3S
.Sase to steady generation. K
The reaction ‘o/th/syst^T™"”
,eVel °f
""“h™'
e^“nr
hem(branM'^< :s^str***^**^ B
effect „f ,he action of the latter (,e ChaSt L??
8eS)^
boi,s
to fall in the K
to ofT"®
“ attacb'd *» >he concept of homeof?,'
? r''?
0" *° liyi"8 organisms the
of theli?r
r°' e -b-f' Si8nals generated by Z ,
,f
" ,MS«“ "* ™ea"s <ha. the B
effects o7
'Vhatever ,be cause of its disturbance or
,
,!
'VayS r'stora Ihe stable state K
the a
•
e act|on of the forces is in disturbing th
°
be greatest possible fall in the
LeSTt
PrOCKSB <* "« PoasiU.lt2 nTm smc- * DMaiW ireatment of .«
are htghly d,verse but, for example,
K
* The character Qf the pr
,
embrane deformations
is easy HL
•he '"Ctotion
the
* -he spec,™„ ^ „d K
I
GOLANT, m. b.,
]
KEILMAN, F., Ph’
BYERGEL’SON, l
9AKEN, H., Biol.
(
SOLANT, M. B. an
TJRTA, M. et at., II
LTLTON, A., Cytos
lir, Moscow, 1987
•EVYATKOV, N. E
ASTED, J. B ., J. Bi
*ND, D. V., IEEE
DLANT, M. B. and
id Medicine (in Ru<
KOV, B. c. and
I
Russian) p. 224 N
OHLICH, H., Adv
m.. Mol. Models of
8 Sept., 1982, pp. 3
'SHITS, M. A., Bic
!iHLICH, H., Ibid.
r» T. M. and AUST
SHINA, M. Ya., lb
JHLICH, H., Ibid.
EDEV, I. V., Tech
— , Moscow, 1972
I
pIIN, R. A. and SAZ
Moscow, 1966
POHL, H. A., Coherent
berg. 1983
BOTNIKOV, O.S.,Dyni
-eningrad, 1985
JOLANT, M. B.
al., I
Objects (in Russian) pn
•EVYATKOV, N. D. e,
(
IDENKO, N. P. et a!., £
bjects (in Russian) pp .
<
ase 2000/08/08
: CIA-RDP96-00789R00310(M001-7
oved For Release 2000/08/08
: CIA-RDP96-00789R0031 00280001 -7
Resonance effect of coherent electromagnetic radiations
1097
associated
f their e:
lependen.ee
equilibrium
rises. Naturally^
4”
olism compel'
e cell).
nee of thermal
ies leads to i
energy exchalge^
ess is linked^
ie vibrationS
fee
ire intense to'n
: of the tempera
6 the external^
ivingrisetoj^f
Ihering t6t$P
"'.-AyA
tolecules axe a
s of the memfera^
e in the numfctf
ition structures the
lecules to the mem*’
nerated by ther®*
5^
ited is not
ss. Wherein
II
:nt of protein
the membranes'fd-
; inevitably letads to
> steady generation,
is of the membrane
crated.
>
Drium to the fences
; down to fall in the
iving organismsm
this means that the
res the stable state
possible fall in the
iled treatment of all
•'•'VV;
the work ofthe cell
^formations
is easy
signals
to explain as a consequence of the impacts on their protiuding portions of the molecules
drawn to them by the e.h.f. field. The use of external e.h.f. signals of the same frequencies
which for the corresponding disturbances would be generated by the organism
itself
niay accelerate the process of generation of the information structure or make it more
effective.
The process described is a system process involving metabolism, protein molecules
and the membrane system alike and if one considers multicellular organisms (which we
have not touched upon in the present review in order not to complicate the exposition)
then one also considers the organism as a whole (naturally its different parts to differing
degrees). The mechanism described, of course, is still highly hypothetical.
REFERENCES
12 .
13 .
14 .
15 .
1*.
17 .
18 .
19 .
20 .
21 .
22 .
23 .
24 .
25 .
26 .
GOLANT, M. B., Biofizika 34: 339, 1989
KE1LMAN, F., Physik in unserer Zeit, No.
2, 33, 1985
BYERGEL’SON, L. D., Membranes, Molecules, Cells
(in Russian)
183 pp., Nauka, Moscow,
1982
HAKEN, H., Biol. Cybern. 56: 11, 1987
GOLANT, M. B. and REBROVA, T. B., Radioelektronika, No. 10, 10, 1986
FURTA, M. et al., IEEE Trans. Biomed. Engng., Vol. BME-33, p. 993, 1986
FULTON, A., Cytoskeleton. Architecture and Choreography of the
Cell (in Russian) 117 pp.,
Mir, Moscow, 1987
DEVYATKOV, N. D. and GOLANT, M. B., Pis’ma v ZhTF 12: 288, 1986
TASTED, J. B., J. Bioelect. 4: 367, 1985
LAND, D. V., IEEE Proc. 134: 193, 1987
GOLANT, M. B. and SHASHLOV, V. A., Use of Millimetre Low Intensity Radiation in Biology
and Medicine (in Russian) pp. 127-131, IRE, Akad. Nauk SSSR, Moscow, 1986
IVKOV,
B. G. and BYERESTOVSKII, G. N., The
Lipid Bilayer of Biological Membranes
(in Russian) p. 224, Nauka, Moscow, 1982
FROHLICH, H., Adv. Electronics and Electron. Phys. 53: 85, 1980
Idem., Mol. Models of Photoresponsiveness. Proc. Nat. Adv. Study Inst., San Moniato, 29 Aug.
to 8 Sept., 1982, pp. 39-42, N. Y., 1983
LIVSHITS, M. A., Biofizika 17: 694, 1972
FROHLICH, H., Ibid. 22: 743, 1977
WU, T. M. and AUSTIN, S., Phys. Lett. 65A: 74, 1978
YUSHINA, M. Ya., Ibid. 91A: 372, 1982
FRGHLICH, H., Ibid. 26A: 402, 1968
LEBEDEV,
I. V., Technique and U.H.F. Instruments
(in Russian)
Vol.
II, 375 pp., Vyssh.
shk., Moscow, 1972
SILIN, R. A and SAZONOV, V.
P., Retarding Systems
(in Russian)
632 pp., Sov. Radio,
Moscow, 1966
POHL, H. A., Coherent Excitations in Biological Systems, pp. 199-210, Springer, Berlin-Heidel-
berg, 1983
SOTNIKOV, O. S., Dynamics of the Structure of the Live Neurone (in Russian) 160 pp., Nauka,
Leningrad, 1985
GOLANT, M. B. et al.. Effect of Non-Thermal Exposure to Millimetre Radiation on Biological
Objects (in Russian) pp. 115-122, IRE, Akad. Nauk SSSR, Moscow, 1983
DEVYATKOV, N. D. et al., Biofizika 28: 895, 1983
DIDENKO, N. P. et al.. Effect of Non-Thermal Exposure to Millimetre Radiation on Biological
Objects (in Russian) pp. 63-77, IRE, Akad. Nauk SSSR, Moscow, 1983
l
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