C NMR (100 MHz, CDCl 3 ) spectrum of metabolite 7; S42: DEPT 135 (100 MHz, CDCl 3 ) spectrum of metabolite 7; S43: APT (100 MHz, CDCl 3 ) spectrum of metabolite 7; S44: (+) ESI-MS analysis of metabolite 7; S45: IR spectrum of metabolite 7; S46: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite papaverine into the active site of PTP1B (PDB ID: 1G7F); S47: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 1 into the active site of PTP1B (PDB ID: 1G7F); S48: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 2 into the active site of PTP1B (PDB ID: 1G7F); S49: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 3 into the active site of PTP1B (PDB ID: 1G7F); S50: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 4 into the active site of PTP1B (PDB ID: 1G7F); S51: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 5 into the active site of PTP1B (PDB ID: 1G7F); S52: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 6 into the active site of PTP1B (PDB ID: 1G7F); S53: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite papaverine into the active site of α-glucosidase (PDB ID: 3A4A); S54: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 1 into the active site of α-glucosidase (PDB ID: 3A4A); S55: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 2 into the active site of αglucosidase (PDB ID: 3A4A); S56: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 3 into the active site of α-glucosidase (PDB ID: 3A4A); S57: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 4 into the active site of α-glucosidase (PDB ID: 3A4A); S58: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 5 into the active site of α-glucosidase (PDB ID: 3A4A); S59: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 6 into the active site of α-glucosidase (PDB ID: 3A4A); S60: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite papaverine into the active site of lipase (PDB ID: 1LPB); S61: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 1 into the active site of lipase (PDB ID: 1LPB); S62: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 2 into the active site of lipase (PDB ID: 1LPB); S63: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 3 into the active site of lipase (PDB ID: 1LPB); S64: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 4 into the active site of lipase (PDB ID: 1LPB); S65: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 5 into the active site of lipase (PDB ID: 1LPB); S66: 2D (left) and 3D (right) patterns demonstrate the binding interaction of metabolite 6 into the active site of lipase (PDB ID: 1LPB).