dataesr/scientific-paragraphs-categorization huggingface dataset:
Monthly ITh values are calculated as the monthly average of daily values, and are well consistent with the homogenized series. All 30 measurement stations are located at low-altitude. There is no estimate of measurement uncertainty provided with this product. In this study, we use this national index rather than more common global datasets such as CRU  (Harris et al. , 2020)  or BEST  (Rohde and Hausfather, 2020) , for two reasons. First, it is available both at the monthly and daily time-scale. Second, the pairwise homogenization procedure is applied to a large sample of raw temperature data, which should make this procedure more accurate than in other datasets. Our observational constraint procedure also requires GSAT observations. We use the HadCRUT5 dataset for GSAT observations since 1850  (Morice et al.
These forced responses could be constrained by various observations. Here, we consider constraints by GSAT observations, and by regional (i. e. , averaged over France) annual mean temperature only -the rationale behind this choice is discussed below. Therefore, x = T all glo , T all ann , T ghg ann , T nat ann , T all jja , T all djf , (2) where each element is an entire 1850-2100 time-series of the forced response, T stands for temperature, 'all', 'ghg' or 'nat' are the subsets of external forcings considered, 'glo' means GSAT (regional temperature is considered where 'glo' is not written), and 'ann', 'jja' or 'djf' are the annual mean, summer mean, and winter mean, respectively. Similarly, y = T obs glo , T obs reg ), (3) i. e. , only observed time-series are used in y. The length of these time-series varies: 1850-2020 for GSAT, 1899-2020 for the French ITh dataset.
Following  Ribes et al. (2021)  uncertainty. Regarding annual mean temperature over France, we follow  Ribes et al. (2016)  in assuming that internal variability follows an AR1(α=0. 2) process. The variance of both global and regional internal variability is derived from observations after subtracting the CMIP6 multimodel mean (crude) estimate of the forced response. Global and regional internal variability are assumed to be independent (observed data exhibit no significant correlation). Lastly, we assume no measurement error in regional temperature observations. Neglecting this term is acceptable since the uncertainty related to internal variability alone (i. e. , the other contributor to Σ y ) is quite large at the regional scale (σ=0. 51°C for each single year).
Acknowledgements. We thank the climate modeling groups involved in CMIP6,  CMIP5  and the  EURO-CORDEX  exercises for producing and making available their simulations. A. R. , Q. S, H. D. acknowledge support by  Météo France ,  CNRS , the  European Union's Horizon 2020 Research and  Innovation Program  under the  EUCP (grant agreement   776613 ) and the  CONSTRAIN  (grant agreement  820829 ) projects.
| in the acute phase Regarding therapy in the acute phase (Table  3  and Figure  2 ), there was consensus that the treatment of seizures with ASMs and anesthetic drugs during the initial 48 hours should be similar to acute treatment of RSE in other conditions. There was also agreement that the management of NORSE/FIRES patients should be carried out in a tertiary center with the appropriate resources and 1. Due to the rarity of disease, multicenter international efforts are essential to understand the mechanisms of NORSE/ FIRES and to improve diagnosis and treatment. 9 (9/9) 100% (48) 0% 2. Development of an international web-based, high-quality clinical registry and database should be a priority. 9 (9/9) 100% (48) 0% 3. In addition to ongoing observational studies, an intervention trial of immunological treatment should be initiated.
| Research and registries The final section addressed future directions for research where the need for multicenter international efforts was emphasized, including the development of an international web-based, high-quality clinical registry and database. There was a very strong consensus in the panel that clinical intervention trials are needed. However, the panel also recognized the concerns and practical difficulties in organizing such trials at the current time and a further discussion on innovative, adaptive trial designs is needed. This consensus report has some important limitations. The rarity of NORSE/FIRES inevitably makes any recommendation or guideline concerning treatment limited due to a lack of high-quality evidence. Because the expert panel was selected based on the experience and expertise of the facilitator group, this may have created a possible selection bias.
It is our hope that this will not only improve patient care but will also initiate the important task of standardizing sampling and developing common data elements (CDEs) including outcome parameters, that is, standardized key terms or concepts that once established may be used in clinical research across sites and over time. Although the evidence is limited at the present time, new studies may alter our current understanding of NORSE/FIRES, and it is therefore important to be familiar with these research developments. The NORSE institute website (www. norse insti tute. org) can serve as a resource for medical professionals and provides an updated bibliography on NORSE and FIRES curated by experts in the field. authoring chapters for UpToDate-Neurology and from Wiley for co-authoring the book "Atlas of EEG in Critical Care," by Hirsch and Brenner; and honoraria for speaking from Neuropace, Natus, and UCB.
Acknowledgements. This project has received funding from the  European Research Council (ERC)  under the European Union's  Horizon 2020 research and innovation programme  (grant agreement No  788212 ) also from the  Excellence Initiative of Aix-Marseille University-AMidex , a  French "Investissements d'Avenir" programme and the labex FOCUS. We thank the electronics, mechanics, cryogenics and administrative groups at  Institut Néel, LPSC  and  LAM. For the outstanding technological and human support we thank the whole  APEX  staff.
Abstract: Purpose: We set out to demonstrate the benefit of using dose-intense cisplatin-based neoadjuvant chemotherapy in terms of overall survival and progression-free survival. Methods: We searched through MEDLINE and Cochrane Library databases up to May 2021 to identify randomized clinical trials comparing the benefit of using cisplatin-based neoadjuvant chemotherapy followed by local treatment with local treatment alone for the treatment of locally advanced cervical cancer. The PRISMA statement was applied. Results: Twenty-two randomized clinical trials were retrieved between 1991 and 2019, corresponding to 3632 women with FIGO stages IB2-IVA cervical cancer. More than 50% of the randomized clinical trials were assessed as having a low risk of bias. There was no benefit of neoadjuvant chemotherapy on overall survival, but there was significant heterogeneity across studies (I 2 = 45%, p = 0.
Statistical Analyses The data were analyzed using R statistical software (version 4. 0. 3; R Foundation for Statistical Computing, Vienna, Austria; http://www. r-project. org, accessed on 27 March 2021). Categorical variables were summarized as numbers (percentage), and continuous variables were summarized as means ± standard deviation (SD) or medians ± interquartile range (IQR). On the articles selected, we performed a meta-analysis (with the package "meta") to assess the prognostic value of neoadjuvant cisplatin-based chemotherapy in locally advanced cervical cancers for overall survival (OS) and progression-free survival (PFS). We assessed the heterogeneity of study results by using the I 2 indicator and Cochran's Q test. I 2 values of 0%, 25%, 50%, and 75% were considered to indicate absence of heterogeneity and low, moderate, and high heterogeneity, respectively.
Uremic Toxins and Risk for Cardiovascular Diseases Some UTs markedly increase the relative risk of CVD in the CKD population. Many in vitro, in vivo, and observational studies have concluded for the impact of dietary and gut-derived UTs on adverse cardiac risk. We systematically searched the literature (the PubMed database, up until 28 February 2022) for publications on the relationship between UTs and CVDs in patients with CKD, by combining the following keywords: ("Chronic kidney disease" OR "renal impairment" OR "kidney disease" OR "chronic kidney failure" OR "chronic renal failure") AND ("Cardiovascular disease" OR "vascular calcification" OR "oxidative stress" OR "coronary artery disease" OR "atherosclerosis" OR "peripheral artery disease" OR "cardiovascular damage" OR "Cardiovascular Diseases" [Mesh] OR "arrythmia" OR "stroke" OR "cardiovascular death" OR "myocardial infarction") AND ("uremic toxin*" OR "uremic retention solute*" OR "cardiovascular toxin*" OR " indoxyl sulfate" OR "p-Cresyl sulfate" OR "p-cresyl glucuronide " OR "indole-3-acetic acid "OR" hippuric acid" OR "kynurenic acid" OR "kynurenine" OR "3-carboxy-4-methyl-5-propyl-2furanpropanoic acid" OR "Phenylacetylglutamine" OR "trimethylamine N-oxide") AND ("in vivo" OR "in vitro" OR "animal*") NOT "hemodialysis" NOT "peritoneal dialysis" NOT "dialysis").
In 2016, Poesen et al. carried out two ancillary analyses of data from the Leuven Mild-to-Moderate CKD Study. One ancillary analysis showed that a lower serum PCS:PCG ratio and high total PCS and PCG levels were associated with fatal and nonfatal atherosclerotic CVDs  [158]. The other demonstrated that an elevated serum PAG level was associated with CVD even after adjustment for age, sex, the presence of DM, prior CVD, and GFR; hence, elevated PAG was considered to be a powerful, independent risk factor for major CVDs (notably MI and stroke)  [159]. The toxic effect of PCS on ATH CVDs dates back to a study conducted in 2010 on 202 stable angina patients with early stage of CKD, presenting that an elevated plasma level of PCS was associated with CAD and it was correlated with the severity of the disease  [160].
Acknowledgements. The authors thank the  Région Île-de-France  and the DIM1HEALTH for supporting this paper. We also acknowledge  Coralie Martin  for her great help co-organising the symposium at the  Muséum National d'Histoire Naturelle in Paris  (" One Health/ Une seule santé ", programme et concept, au prisme des sciences humaines et sociales, October 19th 2018) where some early drafts of this special issue were presented. The authors thank  Laura Amalir  for the English revision, EDPS and in particular  Jean-Lou Justine  for supporting this special issue of Parasite. The authors are grateful to  Sandrine Petry  and  Nicolas Lainé  for review and expert advice. DIM1HEALTH ( Région Île-de-France)  is a grant on infectious diseases, which supported research on infectious diseases under the "One Health" prism (www.
Acknowledgements. We thank  Monique Gentric  for administration management and the  Earth Science Department of the University of Lille  for its help. Thanks to  David Rickard  for his long-lasting interest and for encouraging us to publish these results. Thanks to  Jannick Ingrin  and  Carlos Rodriguez-Navarro , who accepted the idea to submit this preliminary work to the European Journal of Mineralogy, and to  Lourdes Fernández Díaz , associate editor. The reviews by  Daniel D. Gregory  and the anonymous referee were constructive and helpful; merci!Review statement. This paper was edited by  Lourdes Fernández Díaz  and reviewed by  Daniel D. Gregory  and one anonymous referee.
This seems to suggest that it is possible to modify the binding site of neomycin on TAR RNA by conjugation with different groups since 3 specifically binds to the bulge region, while 4 and 7 bind to different sites or can adapt and interact with other regions if the bulge is absent. To confirm these results, we then conducted molecular docking studies about the interaction of the synthesized compounds with TAR. AutoDock program was employed to this aim. Docking of compound 3 confirms that the preferred binding site could be around the bulge region where Tat binding occurs accordingly to what observed experimentally using the mutated sequence (Figure  3A ). More specifically, compound 3 forms various hydrogen bonds and electrostatic interactions in the region going from U23 to A27 and efficiently interacts with all the bases of the bulge (Figure  3B  and C ).
Acknowledgments Thanks are due to  J. M. Guigonis  ( Plateforme Bernard Rossi, CEA TIRO, Nice, France ) for HRMS analyses and to  S. Kovachka  for her help in preparing docking illustrations. PhD fellowship (to C. M. ) is supported by grant from  Agence Nationale de la Recherche  ( ANR-17-CE18-0009 ). PhD fellowship (to M. B. ) is supported by  French Minister for Research and Higher Education. Keywords inhibition, medicinal chemistry, neomycin, RNA cleavage, RNA targeting.
The faunistic knowledge of the Diptera of Morocco recorded from 1787 to 2021 is summarized and updated in this first catalogue of Moroccan Diptera species. A total of 3057 species, classified into 948 genera and 93 families (21 Nematocera and 72 Brachycera), are listed. Taxa (superfamily, family, genus and species) have been updated according to current interpretations, based on reviews in the literature, the expertise of authors and contributors, and recently conducted fieldwork. Data to compile this catalogue were primarily gathered from the literature. In total, 1225 references were consulted and some information was also obtained from online databases. Each family was reviewed and the checklist updated by the respective taxon expert(s), including the number of species that can be expected for that family in Morocco.
Precipitation from July to September is very low, of the order of 100 mm. The dipteran species richness of each biogeographical region of Morocco is summarised in Table  3 , which highlights the great disparity between the different regions and reflects the lack of knowledge about this insect order in some areas of Morocco. The Rif region in the north of the country has the greatest recorded diversity, but this undoubtedly reflects a greater sampling effort in this area, with large parts of the country still very poorly explored for Diptera. The catalogue does not include any data from the southern part of the Moroccan Sahara.
Sources of data Data for the present study were gathered from the literature, supplemented by information taken from a number of websites. The cut-off date for inclusion of species published in the literature is 30 June 2021. Taxonomic, nomenclatural, and distributional data for the present catalogue were obtained from: • studies by various foreign and Moroccan researchers published between 1787 and 2021, including theses, books, catalogues, checklists and notes from the 1997-1998 synthesis studies on Morocco's biodiversity. • data from websites and organisations such as Global Species, the Global Biodiversity Information Facility, the BioSystematic Database of World Diptera, Systema Dipterorum, Catalogue of Life, Systema Naturae 2000 and others, or from relevant homepages specific to particular families.
Arrangement of the catalogue The catalogue includes all names of taxonomically valid species of the Order Diptera so far known to occur in Morocco. For each family, synonyms and alternative combinations that have been published as records of Moroccan provenance are listed under the currently accepted name. The transliteration of Moroccan place names in the literature, maps, and sometimes on data labels presented a small problem. Although it would have been preferable to use standard names, this would have meant changing some place names from their original spellings in the literature. Most transliteration used the French language for spelling and Roman letters, but not all. English was sometimes used, and occasionally also Spanish. Readers are therefore advised to take this into account when searching for place names given in the catalogue and in the cited references.
In some entries, the French terms "affluent" and "aval affluent" are left as in the original citation, because "tributary" may not be an accurate translation in all instances. For some of the sites, the French term refers to a downstream overflow of water into a side tributary or waterfall, whereas for others it refers to an actual tributary feeding into a main river or stream. Older authors were imprecise with localities, and many references did not give the coordinates of localities from which species were collected. We could not reliably provide accurate coordinates for each species. Where known, species depositories are included. Individual family checklists may include, at the end, taxonomic notes and comments on species doubtfully present in the country. New records are indicated with an asterisk (*) and the relevant data listed at the end of the family section.
Collections cited The following museums and collections house some of the specimens mentioned in this catalogue. The National Museum of Natural History of Morocco is located in the Institut Scientifique, Université Mohammed V, Rabat. However, the Diptera collection housed in that museum is not yet included in any world database such as the GBIF Registry of Scientific Collections, https://www. gbif. org/grscicoll, or the Insect and Spider collections of the World Website, http://hbs. bishopmuseum. org/codens/. Gonomyia (Gonomyia) tenella  (Meigen, 1818)  Pierre 1924a, HA, Asni (1200 m); Séguy 1930a, HA, Asni;  Savchenko et al. 1992; Dakki 1997; Starý 2009a; Driauach et al. 2013; Driauach and Belqat 2016 ; Oosterbroek 2020 (CCW) Hoplolabis Osten-Sacken, 1869 Hoplolabis (Parilisia) obtusiapex  (Savchenko, 1982)  Starý 2006, HA, Oasis Meski, AA;  Driauach et al.
Acknowledgements The authors are deeply grateful to the reviewers for their constructive comments, which helped to improve the manuscript. Our sincere thanks are expressed to the subject edi-zana (Oued Laou),  Ras el Ma (Chefchaouen) ; Kettani et al. 2001; Kettani et al. 2010, Rif,  Oued Madissouka  (Talassemtane, 1530 m), Oued Chrafat (Armotah, 900 m),  Oued Kelaâ  (Akoumi, 400 m),  Oued Talembote  (aval affluent Talembote, 155 m); Dakki et al. 2008, MA, Oued Sebou; Kettani and Langton 2011, Rif,  Oued Taida  ( Moulay Abdelsalam , 650 m), cascade  Zarka ,  Dayat En-Nâsser  ( Khandek En-Nâsser , 1177 m);  Kettani and Langton 2012;Kettani and Moubayed-Breil 2018 ,  Rif Micropsectra  junci (Meigen, 1818) Azzouzi et al. 1992, HA, Oued Tensift;Kettani et al. 2001; Kettani and Langton 2012; Kettani and  Moubayed-Breil 2018 ,  Rif Micropsectra  lacustris Säwedal, 1975  Kettani  and Langton 2012, Rif,  Oued Zarka Micropsectra lindrothi Goetghebuer , 1931Azzouzi et al.
Acknowledgments We gratefully acknowledge the assistance and cooperation of  Valery Korneyev  and the late Amnon Freidberg who contributed to the revision of this family. De Lépiney  and Mimeur 1932: 109, AP, Rabat; Mouna 1998; Ebejer and Kettani 2016, Rif, Issaguen (1543 m),  Aïn Tissemlal  (Azilane, 1255 m),  Oued Maggou  (Maggou, 786 m),  Oued Guallet  ( Bni Boufrah , 946 m),  Oued Ametrasse  (Ametrasse, 841 m), AP, Lower Loukous saltmarsh (2 m), MA, Khénifra (17 km SW of Midelt, 1940 m),  Lac Aguelmane Afennourir  (30 km SW of Azrou, 1490 m);  AP (Rabat) -MISR Oscinella nartshukiana Beschovski , 1978 Ebejer and Kettani 2016, Rif,  Ksar El Kebir  (13 m), AP,  Larache Oscinella  nitidigenis (Becker, 1908) Ebejer and Kettani 2016, AA, 6 km N of Errachidia (1010 m),  Oued Ziz  (1052 m) Oscinella nitidissima (Meigen, 1838) Ebejer and Kettani 2016, Rif, Dardara (730 m),  Moulay Abdelsalam  (965 m),  Cap Spartel  ( 155  m),  Oued Laou  (dunes, 2 m), AP, Larache (5 m), MA,  Lac Aguelmane Afennourir  (30 km SW of Azrou, 1490 m) Oscinella pusilla (Meigen, 1830) Ebejer and Kettani 2016, AA,  Lac Tiffert  (4 km W of Merzouga, 702 m) Oscinella ventricosi Nartshuk, 1955 Ebejer and Kettani 2016, Rif,  Oued Boumarioul  ( Aïn Hamra , 560 m), AP, Larache (5 m) Oscinella vindicata (Meigen, 1830) Ebejer and Kettani 2016, AP, Larache (5 m), AA, Merzouga (agriculture under date palms, 714 m) Oscinimorpha Lioy, 1864 Oscinimorpha arcuata (Duda, 1932) Ebejer and Kettani 2016, Rif,  Oued Guallet  ( Bni Boufrah , 946 m),  Oued Jnane Azaghar  ( Bni Boufrah , 997 m) Oscinimorpha longirostris (Loew, 1858) Ebejer and Kettani 2016, Rif,  Ksar El Kebir  (13 m) Oscinimorpha minutissima (Strobl,  1900 )  = Siphonella minutissima Strobl , in Becker and Stein 1913: 93 Becker and Stein 1913, Rif, Tanger; Nartshuk 1984; Ebejer and Kettani 2016, Rif, Dardara (484 m) Oscinimorpha novakii (Strobl,  1893 )  = Conioscinella  novakii (Strobl), in Duda 1933: 58 Duda 1933; Ebejer and Kettani 2016  Oscinisoma Lioy , 1864  Oscinisoma cognatum (Meigen, 1830) = Oscinis rufipes Meigen ,  1830 , with homonym Oscinis rufipes Wiedemann 1830: 580, in Wiedemann 1830: 580, Tanger; synonymy and probable specific identity of homonyms established by Becker 1910:  166 , but without considering the similar Oscinisoma gilvipes (Loew, 1858).
Storms represent an increased source of risk that affects human life, property, and the environment. Prediction of these events, however, is challenging due to their low frequency of occurrence. This paper proposed an artificial intelligence approach to address this challenge and predict storm characteristics and occurrence using a gated recurrent unit (GRU) neural network and a support vector machine (SVM). Historical weather and marine measurements collected from buoy data, as well as a database of storms containing all the extreme events that occurred in Brittany and Pays de la Loire regions, Western France, since 1996, were used. Firstly, GRU was used to predict the characteristics of storms (wind speed, pressure, humidity, temperature, and wave height). Then, SVM was introduced to identify storm-specific patterns and predict storm occurrence.
, 2004). This paper proposes a new approach for predicting the occurrence and characteristics of storms using buoy data and a storm database containing all storm events that occurred in Brittany and Pays de la Loire regions, Western France, since 1996. The GRU model was introduced to predict storm characteristics (wind speed, pressure, humidity, temperature, and wave height). The SVM model attempted to identify stormspecific patterns and applied an SVM-based classifier for storm occurrence prediction. The remainder of this paper is organized as follows. Section 2 covers the study area, the data used, the architectures of the proposed models, and the methodology adopted. Section 3 presents the results of the experiment. Finally, Section 4 discusses the conclusions and summarizes the paper.
Data Used The data used is a combination of a storm database and buoy data. The storm database was obtained from the website Meteo France (http://tempetes. meteo. fr/spip. php?rubrique6), and it represents all the storm events that have occurred in the study area over the past 25 years. The buoy data consists of data collected from station 62163 -Brittany Buoy, which contains records of wind speed, pressure, humidity, temperature, and wave height from  January 1, 1996 , through May 31, 2021. The buoy data was downloaded from the website Meteo France (https://donneespubliques. meteofrance. fr/?fond=produit&id_pro duit=95&id_rubrique=32). The final time series data used to predict storm occurrence and characteristics represent daily records of wind speed, pressure, humidity, temperature, and wave height, in addition to the exact days that have known the occurrence of a storm.