dataesr/scientific-paragraphs-categorization huggingface dataset:
Accession numbers Coordinates and structure factors have been deposited in the Protein Data Bank with accession numbers 6ZFX, 6ZZ7, 6ZG0, 6ZG1, and in the EMDB with accession numbers 11187, 11586, 11190, 11191 for the GraFix-ed, NAD+ supplemented, not treated, and SAM1-2 models and maps, respectively.
( 10 ) The corresponding image is displayed in Fig. 2(c ). It is equivalent to the coherent compounding image computed via delay-and-sum beamforming of the same data set  [16] , constituting a validation of our matrix approach for imaging. Interestingly, the matrix R rr contains much more information than a single ultrasound image. In particular, focusing quality can be assessed by means of the off-diagonal elements of R xx. To understand why this is, R xx shall be expressed theoretically. To that aim, a time-gated version of Eq. (  5 ) can be derived: R xx (z) = H out (z) × Γ(z) × H in (z), (11) where H in (z), Γ(z) and H out (z) are the time-gated submatrices of H in [Eq. (  6 )], Γ [Eq. (  1 )] and H out [Eq. (  7 )] at depth z = ct/2 and central frequency ω c. In the single scattering regime and for spatially-and frequencyinvariant aberration, the previous equation can be rewritten in terms of matrix coefficients as follows: R(x out , x in , z) = dxH out (x -x out , z) ×γ(x, z)H in (x -x in , z).
ACKNOWLEDGMENTS The authors are grateful for funding provided by  LABEX WIFI (Laboratory of Excellence   ANR-10-LABX-24 ) within the  French Program  " Investments for the Future" under Reference  No. ANR-10-IDEX-0001-02 PSL*. This project has received funding from the  European Research Council (ERC)  under the European Union's  Horizon 2020 research and innovation programme  (grant agreement No. 819261 ). W. L. acknowledges financial support from the  SuperSonic Imagine company. L. C. acknowledges financial support from the  European Union 's  Horizon 2020 research and innovation programme  under the  Marie Skłodowska-Curie  grant agreement No. 744840.
Introduction: The incidence of kidney replacement therapy (KRT) for kidney failure varies internationally much more than chronic kidney disease (CKD) prevalence. This ecologic study investigated the relation of CKD prevalence to KRT and mortality risks by world region. Methods: We used data from Global Burden of Disease and KRT registries worldwide with linear models to estimate the percentages of variance in KRT incidence and all-cause mortality explained by ageadjusted prevalence of CKD stages 3 to 5, overall and by gender, in 61 countries classified in 3 regions: high income (n ¼ 28), Eastern and Central Europe (n ¼ 15), and other (n ¼ 18).
CKD Prevalence Crude (all ages) and age-standardized CKD prevalence rates in 2016, expressed as percentages, were extracted overall and by gender from the Global Health Data exchange, GBD Results Tool website (http://ghdx. healthdata. org/gbd-results-tool). In the GBD Study, CKD is defined by an estimated glomerular filtration rate (eGFR) <60 ml/min per 1. 73 m 2 or a need for KRT. Data that inform GBD estimates include microdata or tabulated data obtained from publications (systematic literature reviews), as well as other relevant data sources such as vital registrations, hospital data, and disease registries (citations available on http://ghdx. healthdata. org/gbd-2017/data-input-sources). Prevalence is estimated with a compartmental model that allows data to be incorporated for various epidemiologic indicators, such as incidence and mortality rates, through an integrative Bayesian metaregression.
Incidence of Kidney Replacement Therapy for Kidney Failure Kidney replacement therapy included dialysis or preemptive kidney transplantation and its incidence was expressed per million population (pmp). We used data gathered by the US Renal Data System from national KRT registries worldwide that were willing to contribute data to the international comparison chapter of this report. We extracted data for the crude incidence of KRT for the year 2016, overall and by gender, from the US Renal Data System website (https://www. usrds. org/2018/view/v2_11. aspx). Age-adjusted estimates were not available. 7.
All-Cause Mortality Age-standardized all-cause and CKD-related mortality rates per 100 000 population, overall and by gender, from 2016 were extracted from the World Health Organization (WHO), Global Health Estimates website (http://origin. who. int/healthinfo/global_burden_ disease/estimates/en/). 15  WHO 2016 mortality rates are based on the latest available national-level information about mortality and causes of death at the beginning of 2018. WHO also uses estimates from the 2016 GBD study for countries without usable vital registration data or other nationally representative sources of information for causes of death. 16 CKD-related mortality included deaths from diabetes-related CKD and from CKD due to other causes. Mortality rates were agestandardized according to the WHO 2001 standard population.
Ecologic Associations Between Age-Adjusted CKD Prevalence and KRT Incidence In the high-income region, there was a positive and statistically significant relation between the age-adjusted prevalence of CKD and KRT incidence (Figure  1 ). CKD prevalence explained 40% of the variation in KRT incidence, while 60% remained unexplained. Relations were similar when crude CKD prevalence was used (Supplementary Figure  S1 ). In a subset of the 23 (of the 28 studied) high-income countries with available KRT incidence data stratified by gender, the percentage of explained variance was slightly lower in men than women (49% vs. 56%; Supplementary Table  S5 ). In Central and Eastern Europe, KRT incidence was negatively and statistically significantly related to both the crude and age-adjusted prevalence of CKD and did not differ by gender.
Second, the use of KRT registry data did not enable us to describe the association of CKD prevalence with kidney failure risk because KRT registries cannot capture patients who progress to kidney failure but do not have access to KRT, refuse dialysis, or receive conservative care. Moreover, agestandardized KRT incidence was not available. Third, CKD prevalence may have been affected by the use of different creatinine assays or GFR estimation equations across studies,  6, 8, [18] [19] [20]  although the GBD correction methods should have reduced these disparities by standardizing these estimates. Fourth, the available reference population for age standardization was different for the WHO and the GBD statistics. However, while this may have had an impact on mortality rate and CKD prevalence estimates, it should not have affected the associations we observed.
Change control and document management The DUNE project follows the LBNF/DUNE change control process described in section 7. 5 and section 9. 6. 2. The decision path for changes not impacting the LBNF project or LBNF/DUNE installation activities at SURF is self-contained within the DUNE collaboration management structure. A hierarchy of decision-making levels is defined based on pre-determined thresholds related to the extent of the proposed change with the most significant changes requiring DUNE EB approval. For document management, the DUNE construction project relies on the LBNF/DUNE document management system administrated by the JPO engineering integration team configuration manager. Technical coordination works with the LBNF/DUNE QA manager to ensure that the information needed to track the history of each detector component through construction, assembly, and testing is properly captured within the PBS database.
All integration office installation team members as well as DUNE consortia personnel and LBNF project team members have the right to stop work for any safety issues. Operation of all equipment used for installation activities such as cranes, power tools, and personnel lifts is restricted to team members who have been properly trained and certified for use of that equipment. The safety coordinator for each shift is responsible for ensuring that all team personnel are properly trained and that safety documentation and work procedures are up-to-date and stored within the EDMS. -22 --22 --22 -Documentation, including accident reports, near misses, weekly reports, equipment inspection, and training records is an important component of the LBNF/DUNE ES&H program. The work planning and hazard analysis (HA) program utilizes detailed work plan documents, HA reports, equipment documentation, safety data sheets, personnel protective equipment (PPE), and job task training to mimimize work place hazards and maximize efficiency.
Inspection and acceptance testing Inspection and testing of electrical, mechanical, and structural components, and associated services and processes by consortium members will be conducted using acceptance and performance criteria. ITR forms, travelers, and a traveler database are the primary tools used to organize this activity. Inspections will be conducted in accordance with the graded approach. Once equipment is received at SDWF, the equipment is inspected for shipping damage and accuracy against the bill of lading. Consortium members perform any additional inspection and testing that is required by their design documents either at SDWF or underground in the clean room as the equipment is prepared for installation. Equipment used for all inspections and tests will be calibrated and maintained.
For critical equipment source inspection may be performed in addition. The inspections and tests will be documented on QC plans, travelers, test reports, as applicable. The procedures will define the documentation method. All data from the fabrication and QC processes will be maintained in a database that allows the information to be accessed during installation. Each consortium will define the requirements for the information to be stored in the database. The consortium TDR sections contain information on how they are utilizing the database. In the case of a nonconformance, the nonconformance will be documented by the fabrication facility and a recommended disposition will be provided and forwarded to the consortium technical lead. If the disposition is to scrap or rework so that the item meets the requirements of the specification, the notification to the consortium lead will be for information only, and work can continue on performing the disposition.
All QC data (from assembly and pre-and post-installation into the APA) will be directly stored to the DUNE database for ready access. Monthly summaries of key performance metrics (to be defined) will be generated and inspected to check for quality trends. Based on the ProtoDUNE-SP model, we expect to conduct the following production testing prior to shipping from assembly site. -97 --97 --97 -• dimensional checks of critical components and completed assemblies to ensure that system interfaces ar satisfactory; • post-assembly cryogenic checkouts of SiPM mounting PCBs (prior to assembly into PD modules); • module dimensional tolerances using go/no-go gauge set; and • warm scan of complete module using motor-driven LED scanner (or UV LED array). Following shipping to the USA reception and checkout facility but prior to storage at SDWF, we will conduct mechanical inspection, a warm scan (using identical scanner to initial scan), and cryogenic testing of completed modules (at the CSU CDDF or similar facility).
Following delivery to the underground integration cleanroom, prior to and during integration and Installation, we will • conduct a warm scan (using identical scanner to initial scan); • complete visual inspection of module against a standard set of inspection points, with photographic records kept for each module; • conduct end-to-end cable continuity and short circuit tests of assembled cables; • perform a FE electronics functionality check; • perform installation QC PD system pre-installation testing, following the model established for ProtoDUNE-SP. Prior to installation in the APA, the PD modules will undergo a warm scan in a scanner identical to the one at the PD module assembly facility and we will compare the results. The module will also undergo a complete visual inspection for defects, and a set of photographs of selected critical optical surfaces will be taken and entered into the QC record database.
Lessons learned The LBNF project is currently working with SDSTA and the engineering consultant ARUP to implement ES&H procedures and protocols for training, emergency management, fire protection, and life safety. The Fermilab ES&H section, DOE, and LBNF ES&H have completed a series of assessments of critical SDSTA ES&H programs including underground access, emergency management, electrical safety, rigging, and fire protection. The findings and lessons learned identified in these ES&H program assessments are tracked within the Fermilab issues management database, iTrack. Fermilab completed a review to identify critical lessons learned from the previous underground neutrino project NuMI/MINOS in May 2009. The findings from this exercise were documented in a report entitled Executive Summary of Major NuMI Lessons Learned.
Gb/s, with temporary detector module data). Laboratory tests peak throughput of will allow to 100 Gb/s. demonstrate the performance reach. SP-DAQ-3 DAQ readout 10 µs < readout Storage of the complete Implementation window: The DAQ window < 100 s dataset for up to 100 s is techniques to be shall support storing required by the SNB physics validated on the triggered data of one studies; the typical readout ProtoDUNE setup or more APAs with a window of 5. 4 ms is defined and in test labs. variable size readout by the drift time in the window, from few µs detector; calibration triggers (calibration) to 100 s can be configured to readout (SNB), with a typical data much shorter time readout window for intervals. triggered interactions of 5. 4 ms.
storage volume of throughput of 2 Gb/s, factories phase detector research grants 700 TB. with temporary peak RT-SP-APA-07 APA production quality does module Close oversight on assembly procedures Laboratory tests L M M throughput of 100 not meet requirements will allow to Gb/s. RT-SP-APA-08 Materials shortage at factory Develop and execute a supply chain demonstrate the M L L management plan performance RT-SP-APA-09 Failure of a winding machine Regular maintenance and availability of reach. L L L DP-DAQ-3 DAQ readout -Drive chain parts failure 10 µs < readout spare parts Storage of the complete Implementation window: The DAQ RT-SP-APA-10 APA assembly takes longer window < 100 s Estimates based on protoDUNE. Formal dataset for up to 100 s is techniques to be L M M shall support storing time than planned required by the SNB physics training of every tech/operator validated on the triggered data of one RT-SP-APA-11 Loss of one APA due to an studies; the typical readout Define handling procedures supported by ProtoDUNE setup M L L or more CRPs with a accident window of 7.
Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are medications that are frequently used by athletes. There may also be some abuse of these substances, although it is unclear whether NSAIDs in fact enhance performance. We performed a systematic review and meta-analysis to evaluate the effect of NSAIDs on sport performance indices. Methods: We selected randomized trials from the PubMed and Cochrane Library databases investigating the effects of NSAIDs on sport performance. Volunteers could be healthy adult men and women. Any NSAID, administered by any route, taken prior to any type of exercise, and for any duration could be used. The control intervention could be a placebo, an active substance, or no intervention. We included doubleblind, single-blind, and open-label studies. The primary outcome was the maximum performance in exercises as defined in each study.
Search Strategy Two authors (CG, PN) searched the PubMed (which comprises citations for biomedical literature from MED-LINE, life science journals, and online books) and the Cochrane Library databases up to December 2019 with a combination of Medical Subject Headings (MeSH) or equivalent, or text word terms; search strategies were tailored to individual databases. The full search strategy for the PubMed database is shown in supplementary material, Appendix 1. No restrictions on language or year of publication were applied. ClinicalTrials. gov and Researchgate. net were searched for unpublished and ongoing trials. Reference lists in included (and excluded) studies and reviews were also searched for additional studies. The selection of relevant articles was performed by two authors independently (AR, SO, PN, CC) based on the abstract and title.
Data Extraction All relevant data were extracted by two authors independently (AR, SO, PN) and included the first author, year of publication, study design, sample size, population characteristics, type of intervention, measured outcomes, and respective numerical values. When the numerical values of outcomes for studies were not available or needed clarification (n = 4), the authors were contacted by email. No response was received in two cases. For these studies, the corresponding values were extracted from graphs using Engauge Digitizer 3. 0. When measurements were performed at different time points, we used the closest to the known peak plasma concentration of each molecule. Given the expected diversity of measured outcomes across studies, the slowest speed for isokinetic exercises was considered; eccentric movements when available, otherwise concentric or isotonic movements, and for sprint tests, the highest speed was used.
Results From a total of 1631 records identified, 23 studies were included in the meta-analysis. A total of 1594 records were excluded based on their title and abstract as they did not evaluate sport performance indices, did not assess the topics of interest, or were animal studies. Fortynine articles were fully reviewed; from the bibliography of these six, additional articles were selected and reviewed. Twenty articles were excluded because they did not assess the outcomes of interest, and data could not be extracted from the reported graphs, inadequate intervention; a total of 23 studies were included  [17, 18, [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] [37] [38] [39] [40] [41] [42]  (Fig. 1 ). The characteristics of the included studies are shown in Table  1. One crossover study could be included in the parallel-group analysis  [28] ; twelve studies compared ibuprofen to placebo  [25-30, 32, 36, 39, 41-43] , one study compared ibuprofen to low-dose (75 mg) aspirin  [34] , one study compared indomethacin to placebo  [35]  or no treatment  [24] , three studies compared aspirin to placebo  [17, 18, 38] , and one study compared flurbiprofen to placebo  [40].
5 people to cause 1 case of acute kidney injury  [45]. A similar design could be used to evaluate the ability of NSAIDs to enhance sport performance. The study should be a randomized, doubleblind, placebo-controlled clinical trial with time until exhaustion during a running exercise or the performance during a time-trial, a semi-marathon, or a marathon as a primary outcome. This meta-analysis has some limitations. The search was performed in a limited number of databases; however, it has been shown that using data sources beyond PubMed has a modest impact on the results of systematic reviews of therapeutic interventions  [46]. The methodological quality of studies included is poor, the risk of bias is high, and a publication bias cannot be excluded. The funnel plots is symmetric, but the number of studies for each outcome is low, and most of these studies were not registered before being conducted as recommended for comparative studies  [47].
Observations and data reduction We used IRAM NOEMA to observe the [C I]( 3 P 1 -3 P 0 ), [C I]( 3 P 2 -3 P 1 ), and CO(7-6) line transitions in the GN20 protocluster  (Daddi et al. 2009 ). The observations took place in March 2017 using the D configuration for a total on-source time of 7. 6 hours (program W16DZ, PI: G. Magdis). The [C I]( 3 P 1 -3 P 0 ) line (rest frequency: ν rest = 492. 161 GHz) is redshifted to ν = 97. 355 GHz at z = 4. 0553 with a primary beam of 51. 8. We set our pointing center to the coordinates of GN20 (RA: 12h37m11. 89s, DEC: +62d22m12. 1s) to detect the [C I] and CO lines in this galaxy. Although the D-configuration leads to a relatively low spatial resolution (∼3-6 ), it is the most suitable configuration for a detection experiment as ours. As the observations of the two other GN20 protocluster members, GN20.
2a and GN20. 2b, are affected by a primary beam attenuation of about 0. 2 -0. 7, no lines were detected and we could not derive any constraining measurements for these galaxies. The data were reduced using the GILDAS software packages CLIC and MAPPING. The pipeline-derived flux for our flux cal-ibrator LKHA101 is 0. 24 Jy at 97. 4 GHz, and 0851+202 7. 24 Jy at 160. 1 GHz, with about 20% absolute calibration uncertainty. We produced uv tables with channel widths of 26 km s -1 , achieving an rms of 0. 77 and 1. 35 mJy beam -1 at 3 mm and 1. 86 mm, respectively. We then estimated the continuum emission by averaging the line-free channels. Finally, we subtracted the continuum to produce the line uv tables. The spectra were then extracted using the GILDAS UV_FIT task by assuming an intrinsic source size of 0.
72" (circular Gaussian FWHM), the size of the CO(4-3) line derived from the higher-resolution and signal-tonoise (S/N) data from  Tan et al. (2014). The beam sizes at 3 mm and 1. 86 mm are 6. 72" × 3. 42" and 2. 51" × 1. 72", respectively. The CO and [C I] line intensity maps were produced by collapsing the uv space cube according to the line widths followed by an imaging process (dirty image). We extracted all information directly in the uv plane to avoid introducing any artifacts during the imaging process. We note that assuming an unresolved point-like source in the fitting leads to ∼20% lower line fluxes and 50% worse residuals 1. We searched for emission lines by scanning the S/N spectra as detailed in  Daddi et al. (2015). The estimated continuum at 1. 86 mm of GN20 is 2. 80 ± 0. 13 mJy and 0.
Acknowledgements. We thank the anonymous referee for helpful and constructive comments which improved this paper. This work is based on observations carried out under project number  W16DZ  with the IRAM NOEMA Interferom-eter. IRAM is supported by  INSU/CNRS (France) ,  MPG (Germany)  and  IGN (Spain). IC acknowledges support from  Villum Fonden  research grant ( 13160 ). FV and GEM acknowledge the  Villum Fonden  research grant  13160  "Gas to stars, stars to dust: tracing star formation across cosmic time", and the  Carlsberg Fonden  research grant  CF18-0388  " Galaxies: Rise And Death. DL acknowledges support and funding from the  European Research Council (ERC)  under the European Union's  Horizon 2020 research and innovation programme  (grant agreement No. 694343 ). GEM and ST acknowledge support from the  ERC   Consolidator Grant funding scheme  (project  ConTExt , grant number No.
Experiments were performed in triplicate on two different days for control (in wild-type U2OS cells without any binder expression), stable U2OS cells (expressing TagRFP-T_A1aY1), and wild-type U2OS cells treated with 0. 5 µM SiR-tubulin + 10 µM verapamil and imaged after 30 minutes of SiR-tubulin labeling. More than 400 comets were analyzed from 1-min movies (3-s frame interval) for all the three sets (450, 468, and 414 comets analyzed for control, binder-expressing, and SiR-tubulin-treated cells, respectively) to plot a distribution of the comet velocities from each set. The mean velocities and standard deviations for each set were calculated, and distribution of velocities were plotted on Origin laboratory software. Drug-induced microtubule depolymerization assays (Fig. 7,  A-D ; and Videos 3-6) Stable U2OS cells expressing the red tyrosination sensor (A1aY1 with an N-terminal TagRFP-T) were treated with 10 µM nocodazole (Sigma-Aldrich; catalog no.