dataesr/scientific-paragraphs-categorization huggingface dataset:
mendeley. com/documents/?uuid=8ab50923-cc06-49de-af70-cc578d25b7c4" ] } ], "mendeley" : { "formattedCitation" : "<sup>32</sup>", "plainTextFormattedCitation" : "32", "previouslyFormattedCitation" : "<sup>32</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation. json" }}. Margin re-excision places an additional burden on already busy operating lists and may delay the onset of adjuvant treatments. Supplementary healthcare costs result from a second (or more) anaesthetic, a hospital bed and further histological analysis{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10. 1016/j. jamcollsurg. 2017. 03. 020", "ISSN" : "1072-7515", "author" : [ { "dropping-particle" : "", "family" : "Yu", "given" : "Jennifer", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Elmore", "given" : "Leisha C", "nondropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Cyr", "given" : "Amy E", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Aft", "given" : "Rebecca L", "nondropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Gillanders", "given" : "William E", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Margenthaler", "given" : "Julie A", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "container-title" : "Journal of the American College of Surgeons", "id" : "ITEM-1", "issued" : { "date-parts" : [ [ "2017", "4", "20" ] ] }, "note" : "doi: 10.
1016/j. jamcollsurg. 2017. 03. 020", "publisher" : "Elsevier", "title" : "Cost Analysis of a Surgical Consensus Guideline in Breast-Conserving Surgery", "type" : "article-journal" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=943552e4-406e-43c3-929b-b9869662d2d1" ] } ], "mendeley" : { "formattedCitation" : "<sup>33</sup>", "plainTextFormattedCitation" : "33", "previouslyFormattedCitation" : "<sup>33</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation. json" }}. Due to existing variation in practice in the UK, this prospective study was set up to evaluate the response to the recently published SSO-ASTRO and ABS guidelines. We aimed to describe current margin practice in breast units in the UK and Ireland and to examine the effect that margin policy and local infrastructure have on re-excision rates.
mendeley. com/documents/?uuid=9f21076b-2d18-442b-acca-26c96c337817" ] } ], "mendeley" : { "formattedCitation" : "<sup>34</sup>", "plainTextFormattedCitation" : "34", "previouslyFormattedCitation" : "<sup>34</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/csl-citation. json" }}. A trainee collaborative research method was used following the example of a number of successful trainee led research collaborative studies in breast and general surgery in the UK{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10. 1016/S0140-6736(13)62013-9", "ISSN" : "01406736", "PMID" : "24075040", "abstract" : "Over the past 5 years, trainee-led regional networks in general surgery have been developed to adopt a novel collaborative approach to research in the UK.
", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Fitzgerald", "given" : "J. Edward", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "container-title" : "The Lancet", "id" : "ITEM-1", "issue" : "9898", "issued" : { "date-parts" : [ [ "2013" ] ] }, "page" : "1091-1092", "title" : "Surgical research collaboratives in the UK", "type" : "article", "volume" : "382" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=4576efcc-c4a0-4a11-b071-c6df15056d86" ] } ], "mendeley" : { "formattedCitation" : "<sup>35</sup>", "plainTextFormattedCitation" : "35", "previouslyFormattedCitation" : "<sup>35</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation.
json" }}. A lead trainee was identified at each site either through the network of trainee collaboratives led by the LSRG or were nominated by their unit consultant. Each unit obtained local audit approval. Investigators completed a questionnaire regarding their unit margin policies, as well as providing data on their number of surgeons and breast cancers treated, their screening status, the methods of localising non-palpable lesions and intraoperative margin assessment. A national prospective study was undertaken from 1 st February to 31 st May 2016 on all consecutive patients undergoing wide local excision for DCIS and invasive carcinoma. An online REDCap database was created to capture this data and a server was set up by the information technology department at St George's University of London to store the data securely{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10.
1016/j. jbi. 2008. 08. 010. Research", "ISBN" : "1532-0480 (Electronic)\\n1532-0464 (Linking)", "ISSN" : "1532-0480", "PMID" : "18929686", "abstract" : "REDCap is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: 1) a brief description of the REDCap metadata-driven software toolset; 2) detail concerning the capture and use of study-related metadata from scientific research teams; 3) measures of impact for REDCap; 4) details concerning a consortium network of domestic and international institutions collaborating on the project; and 5) strengths and limitations of the REDCap system. REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions.
", "type" : "article-journal", "volume" : "42" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=a2152330-e244-4271-8de8-81103620eceb" ] } ], "mendeley" : { "formattedCitation" : "<sup>36</sup>", "plainTextFormattedCitation" : "36", "previouslyFormattedCitation" : "<sup>36</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation. json" }}. Access to the database was achieved via the entry of individualised passwords created for each investigator and all data entered into REDCap was stripped of patient identifiers. Each centre was allocated a unique identification code and investigators created a study ID for each patient using the centre ID as a pre-fix. Details of surgery were collected for each patient and included date of primary surgery, closest margin measurements, whether margins were considered involved, whether re-excision took place and details of subsequent re-operations (margin re-excision or mastectomy).
Patients were followed up until the completion of their surgical treatment. Data analysis was performed using SPSS (ver. 23). Chi squared tests and ANOVA were used for categorical data and t-tests and Pearson correlation were used for parametric data. A two-sided 5% alpha level was used to assess statistically significant differences. The study was reported according to STROBE (Strengthening The Reporting of Observational Studies in Epidemiology) guidelines{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "URL" : "https://strobestatement. org/fileadmin/Strobe/uploads/checklists/STROBE_checklist_v4_cohort. pdf", "accessed" : { "date-parts" : [ [ "2017", "6", "1" ] ] }, "id" : "ITEM-1", "issued" : { "date-parts" : [ [ "0" ] ] }, "title" : "STROBE checklist for cohort studies", "type" : "webpage" }, "uris" : [ "http://www.
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", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Pusztai", "given" : "Lajos", "non-droppingparticle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Horowitz", "given" : "Nina R. ", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "container-title" : "New England Journal of Medicine", "id" : "ITEM-1", "issue" : "6", "issued" : { "date-parts" : [ [ "2015" ] ] }, "page" : "503-510", "title" : "A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer", "type" : "article-journal", "volume" : "373" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=bad6cc48-834c-4150-91e7-635215b61ef6" ] } ], "mendeley" : { "formattedCitation" : "<sup>38</sup>", "plainTextFormattedCitation" : "38", "previouslyFormattedCitation" : "<sup>38</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
com/citation-stylelanguage/schema/raw/master/csl-citation. json" }}. However, our study shows a low uptake of routine 4 cavity shave margins with only 24 surgeons incorporating this into their standard practice. Improving uniformity in margin practice would be in line with "Getting It Right First Time", NHS Improvement's national programme to address variation in healthcare provision{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "URL" : "https://improvement. nhs. uk/news-alerts/getting-it-right-first-time-recruits-newclinical-leads/#h2-current-specialities-and-clinical-leads", "id" : "ITEM-1", "issued" : { "dateparts" : [ [ "0" ] ] }, "title" : "Getting it Right First Time", "type" : "webpage" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=7be98ea1-ec33-4b1c-b166-3830cce7ec31" ] } ], "mendeley" : { "formattedCitation" : "<sup>39</sup>", "plainTextFormattedCitation" : "39", "previouslyFormattedCitation" : "<sup>39</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
mendeley. com/documents/?uuid=8ab50923-cc06-49de-af70-cc578d25b7c4" ] } ], "mendeley" : { "formattedCitation" : "<sup>32</sup>", "plainTextFormattedCitation" : "32", "previouslyFormattedCitation" : "<sup>32</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation. json" }}. We have found wide variation in re-excision rates across units with some units reporting re-excision rates up to 40%. Analysis of infrastructure data found that the only variable associated with an increased rate of margin re-excision in participating units was having more than one trainee. This is an interesting finding and may reflect the possible dilution of supervision in these units particularly when trainees jointly perform operations with minimal consultant input.
Data were also analysed to determine whether local margin policies affect re-excision rates. Adoption of the SSO-ASTRO consensus guideline in invasive disease has been shown to reduce re-excision rates both in the USA{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10. 1245/s10434-016-5516-5", "ISSN" : "1068-9265", "abstract" : "BACKGROUND: In February 2014 , the Society of Surgical Oncology and the American Society for Radiation Oncology released guidelines standardizing a negative margin after breast-conserving surgery (BCS) as \"no ink on tumor\" in patients with early-stage invasive cancer. We sought to determine whether reexcision rates after initial BCS decreased after guideline publication, using the ASBrS MasterySM of Breast Surgery Program. METHODS: Between January 2013 and June 2015, data from the ASBrS MasterySM database was analyzed to determine reexcision rates pre and post guideline publication.
Reasons for reexcision were evaluated as were the associations with patient and provider characteristics. Chi square test, Fisher's exact test, Student's t test, ANOVA, and multivariable logistic regression were used as appropriate. All analyses were performed using Microsoft Excel and SPSS, with p value <0. 05 as significant. RESULTS: Among 252 providers, the overall reexcision rate after initial BCS decreased by 3. 7 % from 20. 2 to 16. 5 % (p < 0. 001). Notable was a 13. 8 % decrease (p < 0. 001) in reexcisions being done for close margins. Of the analyzed physician and patient characteristics the majority of subgroups showed decreases between the two time periods; however, only \"Percent Breast Surgery in Practice\" was significant. On adjusted analysis, there were no specific patient factors associated with a reduction in reexcision rates.
CONCLUSIONS: Following the SSO-ASTRO \"no ink on tumor\" guideline publication, a reduction in overall reexcision rates and reexcision rates for close margins after initial BCS was observed in the ASBrS MasterySM database. More widespread implementation outside this group of early adopters is anticipated with ongoing dissemination. ", "author" : [ { "dropping-particle" : "", "family" : "Schulman", "given" : "Amanda M. ", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Mirrielees", "given" : "Jennifer A. ", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Leverson", "given" : "Glen", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Landercasper", "given" : "Jeffrey", "nondropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Greenberg", "given" : "Caprice", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Wilke", "given" : "Lee G.
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com/citation-style-language/schema/raw/master/csl-citation. json" }} and in individual UK breast units{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "author" : [ { "dropping-particle" : "", "family" : "Tang S. , Pereira B. , May J. , Reddy D. ", "given" : "Sharma AKS. ", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "container-title" : "EJSO", "id" : "ITEM-1", "issue" : "S35-S36", "issued" : { "date-parts" :  [ [ "2016" ]  ] }, "title" : "Excision margins in breast conservation therapy (BCT) \u2013 The effect of the Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) consensus on our practice. EJSO 2016: 42; S35-S36)", "type" : "article-journal", "volume" : "42" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=374e7253-5e7b-48db-94b0-2a715dd464d3" ] } ], "mendeley" : { "formattedCitation" : "<sup>42</sup>", "plainTextFormattedCitation" : "42", "previouslyFormattedCitation" : "<sup>42</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
com/citation-style-language/schema/raw/master/cslcitation. json" }}. However, our data show that if all participating breast units applied SSO-ASTRO's guidelines, this would only lower the national re-excision rate from 17. 2% to 15. 4% (Figure  1 ). This is similar to the re-excision rate seen at a large unit in the USA following adopting the SSO-ASTRO guidelines (rates fell from 21. 4% to 15. 1%){ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "author" : [ { "dropping-particle" : "", "family" : "Rosenberger", "given" : "LH", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Mamtani", "given" : "A", "non-droppingparticle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "S", "given" : "Fuzesi", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Stempel", "given" : "M", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Eaton", "given" : "A", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Morrow", "given" : "M", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Gemignani", "given" : "ML", "nondropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "container-title" : "Annals of surgical oncology", "id" : "ITEM-1", "issue" : "10", "issued" : ] } ], "mendeley" : { "formattedCitation" : "<sup>41</sup>", "plainTextFormattedCitation" : "41", "previouslyFormattedCitation" : "<sup>41</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
C. L. HENDRIKS", "given" : "Md*", "non-droppingparticle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Bre", "given" : "", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" } ], "containertitle" : "Cancer", "id" : "ITEM-1", "issued" : { "date-parts" :  [ [ "1985" ]  ] }, "page" : "979-990", "title" : "Histologic Multifocality of Tis, T I -2 Breast Carcinomas. implications for Clinical Trials of Breast-Conserving Surgery", "type" : "article-journal", "volume" : "56" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=2ce66c29-353d-46ab-9ffe-94c86d2f98ae" ] } ], "mendeley" : { "formattedCitation" : "<sup>43</sup>", "plainTextFormattedCitation" : "43", "previouslyFormattedCitation" : "<sup>43</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
", "type" : "articlejournal", "volume" : "347" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=2411ba6b-9560-48ac-8235-bb3b4011e58f" ] }, { "id" : "ITEM-5", "itemData" : { "DOI" : "10. 1056/NEJMoa020128", "ISBN" : "1533-4406 (Electronic)\\r0028-4793 (Linking)", "ISSN" : "1533-4406", "PMID" : "12192016", "abstract" : "BACKGROUND: In 1976, we initiated a randomized trial to determine whether lumpectomy with or without radiation therapy was as effective as total mastectomy for the treatment of invasive breast cancer. METHODS: A total of 1851 women for whom follow-up data were available and nodal status was known underwent randomly assigned treatment consisting of total mastectomy, lumpectomy alone, or lumpectomy and breast irradiation. Kaplan-Meier and cumulative-incidence estimates of the outcome were obtained.
mendeley. com/documents/?uuid=ac505db9-c427-4f82-a7d1-35034d10f8f3" ] } ], "mendeley" : { "formattedCitation" : "<sup>12,13,15\u201318</sup>", "plainTextFormattedCitation" : "12,13,15\u201318", "previouslyFormattedCitation" : "<sup>12,13,15\u201318</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/csl-citation. json" }}. Nor should we go down the route of excising larger volumes of tissue as this will increase the risk of poor cosmetic outcomes and we have already discussed that wide margins are not necessary for local control{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10. 1245/s10434-014-3480-5", "ISBN" : "1068-9265", "ISSN" : "1068-9265", "PMID" : "24473640", "abstract" : "Purpose: There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT).
mendeley. com/documents/?uuid=db62836c-3d64-49df-8f72-aa33c7d56cff" ] } ], "mendeley" : { "formattedCitation" : "<sup>26</sup>", "plainTextFormattedCitation" : "26", "previouslyFormattedCitation" : "<sup>26</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github. com/citation-style-language/schema/raw/master/cslcitation. json" }}. Instead, complete excision rates should be improved by better identification of patients who are at increased risk of margin involvement (e. g. those with DCIS{ADDIN CSL_CITATION { "citationItems" : [ { "id" : "ITEM-1", "itemData" : { "DOI" : "10. found in the type of reoperation between patients with DCIS and those with IBC. </p><h3>Conclusions and Relevance</h3><p>A lower reoperation rate after wire-guided BCS was found in this study than those shown in previous studies.
", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "dropping-particle" : "", "family" : "Caddy", "given" : "C. M. ", "non-dropping-particle" : "", "parse-names" : false, "suffix" : "" }, { "droppingparticle" : "", "family" : "Meulen", "given" : "J. H. P. ", "non-dropping-particle" : "van der", "parse-names" : false, "suffix" : "" } ], "container-title" : "BMJ", "id" : "ITEM-2", "issue" : "jul12 2", "issued" : { "date-parts" : [ [ "2012" ] ] }, "page" : "e4505-e4505", "title" : "Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics", "type" : "article-journal", "volume" : "345" }, "uris" : [ "http://www. mendeley. com/documents/?uuid=8ab50923-cc06-49de-af70-cc578d25b7c4" ] } ], "mendeley" : { "formattedCitation" : "<sup>32,44</sup>", "plainTextFormattedCitation" : "32,44", "previouslyFormattedCitation" : "<sup>32,44</sup>" }, "properties" : { "noteIndex" : 0 }, "schema" : "https://github.
abstract" : "BACKGROUND: Completeness of excision is the most important factor influencing local recurrence after breast-conserving surgery (BCS). The aim of this casecontrol study was to determine factors influencing incomplete excision in patients undergoing BCS. \\n\\nMETHODS: Women with invasive breast cancer treated by BCS between 1 June 2008 and 31 December 2009 were identified from a prospectively collected database in the Edinburgh Breast Unit. The maximum size of the tumour, measured microscopically, was compared with the size estimated before operation by mammography and ultrasound imaging. A multivariable analysis was performed to investigate factors associated with incomplete excision. \\n\\nRESULTS: The cohort comprised 311 women, of whom 193 (62\u00b71 per cent) had a complete (CE group) and 118 (40\u00b77 per cent) an incomplete (IE group) excision.