3 LIST OF ABBREVIATIONS AND DEFINITION OF TERMS 3. 1 List of Abbreviations Clinical Study Protocol Sponsor: TiGenix S. A. U. Version: Final, Version 7 incorporating Amendment 5 Study Code: Cx611-0204 Date: 19 December 2019 EudraCT No. : 2015-002994-39 kg Kilogram LOS Length of stay LPS Lipopolysaccharide MAP Mean Arterial Pressure MedDRA Medical Dictionary for Regulatory Activities Abs AC AE MIP-2 PaO 2 AESI AIDS APACHE APTT ATIMP BAL BL CA CABP PBMC PNA FISH PSB PT RANTES RBC REB RNA rt-PCR CAP CI SAE SAP CRF CRO CTA CURB CURB-65 CXR DMC DMSO eASCs EC ECG eCRF EDTA EEA EOS ETA EU FiO 2 GCP GMP GP HAART HAP hCG HIV HLA ICH ICU IEC HL HL I P r o p e r t y RT T P P hCG CG HIV HIV o f T a k e d a : F o r N o n -C Antibodies Adjudication committee Macrophage inflammatory protein-2 Partial pressure of Oxygen Adverse event Adverse event of special interest Acquired immune deficiency syndrome Acute Physiology and Chronic Health Evaluation Activated partial thromboplastin time Advanced therapy investigational medicinal product Broncho Alveolar Lavage Baseline Competent authority Peripheral blood mononuclear cells Peptide nucleic acid fluorescent in situ hybridization Protected specimen brush Preferred term; prothrombin time Regulated on activation normal T cell expressed and secreted Red blood cell count Regional Ethics Board Ribonucleic acid A p p l i c a b l e T e r m s o f U s e Real-time polymerase chain reaction Community-acquired bacterial pneumonia Community-acquired pneumonia Serious adverse event t h e Statistical Analysis Plan Confidence interval Case report form Contract research organization Clinical Trials Authorisation Confusion, elevated blood urea nitrogen level, respiratory rate, and blood pressure (score) Confusion, elevated blood urea nitrogen level, respiratory rate, and blood pressure plus age ≥65 years score Chest X-ray Data Monitoring Committee Dimethyl sulfoxide Expanded Adipose-derived Stem Cells European commission Electrocardiogram Electronic case report form Ethylenediaminetetraacetic acid European Economic Area End Of Study Endotracheal Aspiration European Union Fraction of inspired Oxygen Good Clinical Practice Good Manufacturing Practice General Practitioner Highly active antiretroviral therapy Hospital acquired pneumonia Human chorionic gonadotropin Human immunodeficiency virus Human leukocyte antigen complex International Conference on Harmonization Intensive care unit Independent ethics committee E o m s e CCI SAS Statistical analysis systems SBP Systolic blood pressure SUSAR Suspected unexpected serious adverse reaction sCABP Severe community-acquired bacterial pneumonia S u b j e c t t o rogen lev SD Standard deviation gen le a n d ea nitrog SoC Standard of Care ea nitro SOC System organ class n l y SOFA Sequential Organ Failure Assessment O SOM Study Operations Manual mmittee mitt SOP Standard operating procedure e e pose ose-deri d TEAE Treatment -emergent adverse events e r c i a l U ommissio mmissi TLR Toll-like receptor rdiogram diogra onic case TNF Tumour necrosis factor nic cas m ylenediam enedi y VAP Ventilator associated-pneumonia European uropea End O VFD Ventilator free days End O End En WBC White blood cell count IFN Interferon IL Interleukin IMP Investigational medicinal product IMPD Investigational medicinal product dossier IRT Interactive Response Technology IV Intravenous.