Acknowledgements We thank the research participants and their families for their contribution to GENFI. Some authors of this manuscript are members of the  European Reference Network for Rare Neurological Diseases  (project  ID :  739510 ). Neurodegenerative Science,  Van Andel Institute ,  Grand Rapids , Michigan, MI 49503, USA 3 ; Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester , Manchester, UK 4 ;MRC Prion Unit,  Department of Neurodegenerative Disease ,  UCL Institute of Neurology, Queen Square, London, UK 5 ;Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands 6 ;Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands 7 ;Cognitive Disorders Unit, Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa, Spain 8 ;Neuroscience Area, Biodonostia Health Research Insitute, San Sebastian, Gipuzkoa, Spain 9 ;OSATEK, University of Donostia, San Sebastian, Gipuzkoa, Spain 10 ;Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Barcelona, Spain 11 ;Imaging Diagnostic Center, Hospital Clínic, Barcelona, Spain 12 ;Stroke Unit, ASST Brescia Hospital, Brescia, Italy 13 ;Neurology, ASST Brescia Hospital, Brescia, Italy 14 ;Neuroradiology Unit, University of Brescia, Brescia, Italy 15 ;Biotechnology Laboratory, Department of Diagnostics, ASST Brescia Hospital, Brescia, Italy 16  ; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada 17 ;Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada 18 ;Baycrest Health Sciences, Rotman Research Institute, University of Toronto, Toronto, Canada 19 ;The University Health Network, Toronto Rehabilitation Institute, Toronto, Canada 20 ;The University Health Network, Krembil Research Institute, Toronto, Canada 21 ;Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, Solna, Sweden 22 ;Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Sweden 23  ; Department of Clinical Neuroscience ,  Karolinska Institutet , Stockholm, Sweden 24 ; Division of Clinical Geriatrics ,  Karolinska Institutet , Stockholm, Sweden  25  ; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan , Italy  26  ;  University of Milan ,  Centro Dino Ferrari , Milan, Italy 27 ; Department of Clinical Neuroscience, University of Cambridge, Cambridge ,  UK 28  ; Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada 29 ;Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada 30 ;Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London ,  Ontario ,  Canada 31  ; Department of Neurosciences, Mayo Clinic, Jacksonville, Florida ,  USA 32  ; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany 33  ; Center for Neurodegenerative Diseases (DZNE) ,  Tübingen, Germany 34  ; Division of Neuropsychology, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany 35  ; Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany 36 ;Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium 37 ;Neurology Service, University Hospitals Leuven, Belgium; Laboratory for Neurobiology, VIB-KU Leuven Centre for Brain Research, Leuven, Belgium 38 ;Geriatric Psychiatry Service, University Hospitals Leuven, Belgium 39 ;Neuropsychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium 40 ;Laboratory of Neurosciences, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal 41  ; Faculty of Medicine, University of Lisbon, Lisbon, Portugal 42 ;Laboratory of Language Research, Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Lisbon, Portugal 43  ; Department of Neurosciences and Mental Health, Centro Hospitalar Lisboa Norte -Hospital de Santa Maria & Faculty of Medicine, University of Lisbon, Lisbon, Portugal 44  ; Instituto Ciencias Nucleares Aplicadas a Saude, Universidade de Coimbra, Coimbra ,  Portugal 45  ; Neuropathology Unit and Department of Neurology, Centro Hospitalar do Porto -Hospital de Santo António, Oporto ,  Portugal 46  ; Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy 47  ; Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 48 Centre of Neurosciences and Cell Biology, Universidade de Coimbra, Coimbra, Portugal; 49 Neurology Department, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal; 50 Alzheimer Disease Research Unit, McGill Centre for Studies in Aging, Department of Neurology & Neurosurgery, McGill University, Montreal, Québec, Canada ; 51 Translational.