dataesr/scientific-paragraphs-categorization huggingface dataset:
ZMUC Zoological Museum, University of Copenhagen, Copenhagen, Denmark ZSM Zoologische Staatssammlung, Munich, Germany. In the specimen data the dates are given as dd. mm. yyyy, and coordinates as positive (north or east) or negative (south or west) decimal degrees latitude and longitude. Morphological terminology mostly follows  Viitasaari (2002) , but sawtooth is used instead of serrula (see  Malagón-Aldana et al. 2017) , and the large, ventrally situated, more or less triangular flange above each sawtooth is called a spurette (following  Ross 1943; see Figs 108, 112 arrows). Images of complete imagines and morphological details were made at the SDEI with Leica cameras attached to a variety of microscopes. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3.
Ambiguous positions (i. e. , double peaks in chromatograms of both strands) due to heterozygosity were coded using IUPAC symbols. Sequences reported here have been deposited in the GenBank (NCBI) database (accession numbers MK624656-MK624923 and MK720818-MK720821), although not all of them are analysed here (covered in further publications on some of the genera not treated here). Some of the sequences analysed here were originally published by  Schmidt et al. (2017)  and  Prous et al. (2016 Prous et al. ( , 2017)). Alignment of COI, NaK, and TRRAP sequences was straightforward because of the lack of indels (insertions or deletions). Alignment of POL2 and TPI was also straightforward without introns, but these were retained in some analyses published elsewhere  (Liston et al. 2019a ) and aligned manually.
boldsystems. org/) BIN database. Some of the COI barcode sequences used here were obtained from BOLD (http://www. boldsystems. org/). In this case, DNA extraction, PCR amplification, and sequencing were conducted at the Canadian Centre for DNA  Barcoding (CCDB)  in Guelph, Canada, using standardised high-throughput protocols  (Ivanova et al. 2006 , deWaard et al. 2008) , available online under www. ccdb. ca/ resources. php. DNA aliquots of SDEI vouchers are deposited in the DNA storage facility of the SDEI (including those that were originally extracted in CCDB).
In the absence of publicly available evidence, we are sceptical that  Wei and Nie (1998)  managed to create a highly informative morphological data matrix that could be used to propose a well-supported and stable phylogeny of Tenthredinidae. The cladistic analyses by  Vilhelmsen (2015) , based on 146 morphological characters, demonstrate how difficult it is using such methods to achieve a high level of statistical support and stability for phylogenies within Tenthredinidae. At the same time, the statement by  Niu et al. (2019: page [2] ) that the results of  Prous et al. (2014)  were based "only on 400-bp sequences of the barcode region", is simply wrong. As clearly described in  Prous et al. (2014: 3)  there were two datasets based on four genes (two mitochondrial and two nuclear), one of them (134 specimens) with little missing data (19 specimens missing one gene and seven specimens missing two genes) and the second one (79 specimens) with more missing data (21 specimens missing one gene, eight specimens missing two genes, and 15 specimens missing three genes).
This approach was adopted so that type species of some genera for which only one gene was available could be included in the analyses (only one specimen in the second dataset had 422 bp of COI, all others had at least 658 bp of COI). In the end, the new data presented by  Niu et al. (2019)  are irrelevant to their discussion on the classification of the Nematinae, because of completely inadequate taxon sampling: they analysed only two specimens of Nematinae. Their data are in fact consistent with all previously proposed classifications, not just with Wei and Nie (1998) as they stated. Although the Nematini and Dineurini both comprise a relatively large number of genera, the large majority of Holarctic nematine species belong to just two genera of Nematini, Euura and Pristiphora. The proportional representation of genera and species in the Oriental Realm is at present unclear, but compared to the Holarctic Realm, existing data point to a lesser number of Euura species, and more Pristiphora, while the number of species belonging to diverse genera of non-Nematini may also be greater  (Taeger et al.
Acknowledgements This work was made possible through funding by the  Swedish Taxonomy Initiative. For the loan of material, and access to collections, we thank  Kees van Achterberg  (RMNH),  Ewald Altenhofer  ( Etzen, Austria ),  Christer Hansson  and  Rune Bygebjerg  (MZLU),  Frank Koch  (ZMHB),  Jean Lacourt  ( Igé, France), Thierry Noblecourt (Quillan, France ),  Juho Paukkunen  (FMNH),  Stefan Schmidt  (ZSM),  Zoltán Vas  (HNHM),  Lars Vilhelmsen  (ZMUC),  Matti Viitasaari  (Helsinki),  Veli Vikberg  ( Turenki ) who also provided data on the larva of Nematus princeps, and the staff of the  Swedish Malaise Trap Project ,  Station Linné , Öland (particularly  Mattias Forshage ,  Kajsa Glemhorn ,  Dave Karlsson , and  Pelle Magnusson ). Reviews by  Jean-Luc Boevé  and an anonymous reviewer helped to improve the manuscript.
Based on the performed imaging, hormonal tests, and pathological evaluation of oligobiopsy, 81 incidentalomas, 2 pheochromocytomas, 1 case of adrenocortical carcinoma, and 1 liver cyst were diagnosed. In the final analysis, 79 patients were included, and 6 cases with incomplete data and in which the maximum tumor size exceeded 6 cm were excluded. CEUS was a part of the routine assessment introduced to the patient work-up and was approved by the institution's supervisors. The study protocol was accepted by the Bioethics Committee on 15 December 2009 (KNW/0022/KB1/153/I/09). All patients participating in the study  In the final analysis, 79 patients were included, and 6 cases with incomplete data and in which the maximum tumor size exceeded 6 cm were excluded. CEUS was a part of the routine assessment introduced to the patient work-up and was approved by the institution's supervisors.
The study protocol was accepted by the Bioethics Committee on 15 December 2009 (KNW/0022/KB1/153/I/09). All patients participating in the study In the final analysis, 79 patients were included, and 6 cases with incomplete data and in which the maximum tumor size exceeded 6 cm were excluded. CEUS was a part of the routine assessment introduced to the patient work-up and was approved by the institution's supervisors. The study protocol was accepted by the Bioethics Committee on 15 December 2009 (KNW/0022/KB1/153/I/09). All patients participating in the study gave written informed consent for the performed examinations and procedures. Figures showing tumors were also obtained through the patients' informed consent for their use.
Data Analysis Based on the US, CEUS, and CT or MRI measurements of adrenal gland tumors, we calculated their volumes, which were subsequently employed in a further comparative assessment. The types of adrenal tumor vascularization in our study were classified as follows: 1. lack of vascularization, 2. peripheral vascularization, 3. peripheral-central vascularization, and 4. central vascularization. and c-transverse ). Nominal and ordinal data were expressed as percentages, while interval data were expressed as a mean value ± standard deviation in the case of normal distribution or as median (lower quartile -upper quartile) in the event of data with skewed or non-normal distribution. Distribution of variables was evaluated by the Shapiro-Wilk test and quantile-quantile plot, and homogeneity of the variances was assessed by the Levene test.
MRI myocardial scar segmentation Late gadolinium-enhanced cardiac MRI was performed 2-3 months after the creation of myocardial infarction. Image processing was performed by 2 trained technicians using the MUSIC software (EQUIPEX MUSIC, Liryc, Universite ́ de Bordeaux/INRIA, Sophia Antipolis, France). Segmentation was performed as described previously. (7, 8)  Briefly, the cardiac chambers, ventricular epicardium, ascending aorta, and coronary sinus (CS) were segmented using semi-automatic methods. (8)  From left ventricular (LV) wall segmentation, adaptive histogram thresholding was applied in order to segment dense scar (threshold set at 50% maximum signal intensity) and grey zone (from 35 to 50%)  (9) (10) (11).
These authors contributed equally to this work. FUNDING Equipex MUSIC   ANR-11-EQPX-0030 ,  IHU LIRYC ANR-10-IAHU-04 , research grant from  Abbott. DISCLOSURE  Drs Haïssaguerre ,  Hocini, Jaïs  and  Sacher:Lecture  fees from  Biosense Webster and Abbott. Drs.
Acknowledgements This work has been carried out within the framework of the  EUROfusion. Consortium  and has received funding from the  Euratom  research and training programme  2014-2018  under grant agreement no. 633053  and from the  RCUK Energy Programme  [grant number  EP/ I501045 ]. To obtain further information on the data and models underlying this paper please contact PublicationsManager@ccfe. ac. uk. The views and opinions expressed herein do not necessarily reflect those of the  European Commission.
Clusters Clonal relatedness among all CPE isolates was investigated by pulsed-field gel electrophoresis (PFGE), performed according to the manufacturer's instructions (BioRad, Marnes-la-coquette, France). PFGE profiles were analyzed using Bionumerics software (Applied Maths, Sint-Martens-Latem, Belgium) and band patterns were analyzed according to the Tenover criteria. [4].
The effects of regional analgesia/anesthesia and of local anesthetics are also being assessed in some RCTs. Most prospective RCTs compare TIVA ± regional anesthesia with inhalation anesthesia for breast and colon cancer surgery (NCT2089178, NCT00938171, NCT418457, NCT2005770, NCT01975064). Other types of cancer are also being studied e. g. , pancreatic cancer (NCT2335151)  [58]. There are a few studies comparing the effects of TIVA versus inhalation anesthesia and of lidocaine infusion on long-term outcomes and recurrence rates for breast and colon cancer (NCT02839668, NCT02786329, NCT01204242). Finally, we will consider the possible role of opioids, in negative outcomes for patients undergoing cancer surgery.
Also noteworthy is the apparent association between use of the peripheral opioid antagonist methylnaltrexone, with longer survival in cancer patients who receive opioids  [64]. What is needed are prospective, randomized, controlled clinical trials comparing opioid based analgesia perioperatively during tumor resection surgery of curative intent with alternative anesthetic-analgesic techniques, with long-term oncologic outcomes (recurrence free survival, overall survival) as the clinical endpoints, in combination with biological ones. Such studies take years to complete patient enrolment and follow-up, and one such trial (NCT00418457) may report the results in 2019.
In a prospective, randomized, multicenter trial in patients undergoing surgery for colorectal cancer, 280 patients were randomized to receive epidural anesthesia and analgesia for perioperative pain management or intravenous PCA morphine. The primary aim of this study was to assess the time to cancer recurrence (by CT performed yearly) or all-cause mortality. Interestingly, as surgical techniques evolve, there is stratification to laparoscopic surgery/open-surgery and colon/rectal surgery. The study is expected to be complete by the end 2019 and all patients will be followed-up for a period of 5 years. Retrospective data on patients operated for rectal cancer surgery points to favorable outcome in patients having epidural analgesia. No prospective study with an adequate number of patients has yet been completed but important findings are awaited.
Inflammation and NSAIDs The story of the NSAIDs in this context began with the identification of a bimodal pattern of hazard of relapse among early stage breast cancer patients, in multiple databases. Using computer simulation and access to a high-quality database from Milan for patients treated with mastectomy only, it was proposed that relapses within 3 years of surgery are stimulated somehow by the surgical procedure. Retrospective breast cancer data suggested a plausible mechanism. Use of ketorolac, a common NSAID analgesic, was associated with superior disease-free survival  [40, 70]. The expected prominent early relapse events in months 9 to 18 were reduced 5-fold. Transient systemic inflammation accompanying surgery (identified by IL-6 in serum) could facilitate angiogenesis of dormant micrometastases and proliferation of dormant single cells and could have been effectively blocked by the perioperative NSAID.
If this observation holds up to further scrutiny, it could mean that the use of this safe, inexpensive and effective anti-inflammatory agent at surgery might substantially reduce early relapses and reduce mortality by 25-50%. The findings have recently been confirmed in a mouse-model by Krall et al. [71]  and in a retrospective study by Desmedt et al. [72]. However, the Ketorolac in Breast Cancer trial (NCT01806259), a multicenter, placebo-controlled, randomized phase III trial in high-risk breast cancer patients, has recently shown that a single dose of ketorolac tromethamine versus placebo 30 min before surgery, does not increase disease-free survival in high risk breast cancer patients  [73, 74]. Overall survival is also comparable. As no safety concerns were observed, multiple doses could be studied during the perioperative period.
The metrology campaign results indicated good consistency between the horizontal displacements done on the gyrotron and the measurements taken by the photogrammetry camera. For example, when moving the gyrotron by 1 mm in x-direction, the metrology targets were measuring a displacement in the same direction in the range 0. 936 to 1. 015 mm. Additionally, a minor rotation of the gyrotron axis was detected with data extracted from the photogrammetry (maybe due to the different degrees of freedom allowed with the XY-table). Figure  14  shows further details on the data measured for this horizontal displacement. The possible tilting of the gyrotron when acting on the XY-table and when operating with the collector water cooling ON (gyrotron under the effect of vibrations) were also verified. After concluding the metrology campaign and setting the RF stability regions, the gyrotron was moved to the center of the optimal operating region to perform the high-power long-pulse test campaign.
interest for this work. TR has received speaker and consulting honoraria from  Fresenius Medical Care, Baxter Healthcare Corp, Biomérieux, Medtronic, Nikkiso  and  B. Braun. He  is the principal investigator of the ECRO trial, comparing the effects of the oXiris ® membrane to a standard membrane on endotoxins and cytokines levels during peritonitis-induced septic shock ( NCT 03426943 ). AS has received a grant from the  Leenaards Foundation , speaker honoraria from  Fresenius Medical Care, Baxter Healthcare Corp  and consulting honoraria from  B. Braun Melsungen AG. He is the principal investigator of the CCCC trial, a pilot trial evaluating the impact of CytoSorb ® during cardiac surgery ( NCT02775123 ).
Study population A total of 79 BC patients (64 left-sided and 15 rightsided) were included in the analysis. Baseline patients' characteristics are shown in Table  1. The mean age was 58 ± 9 years. Most patients (84%) were diagnosed with an invasive ductal carcinoma, underwent breast conserving surgery (97%) and received endocrine therapy (76%). The prescribed radiation dose was 50 Gy in 25 sessions for 75% of the population. Concerning cardiac risk factors, 24% of the patients had hypertension and 30% hypercholesterolemia. No significant differences in these characteristics were observed between left-sided and right-sided BC patients (data not shown).
On the other side, the strain is not uniform over the LV. The LV wall is not homogenous and comprises an endocardial, a midmyocardial, and an epicardial layer  [25]. Recent 2DSTE software allows separate evaluation of myocardial layers deformation  [33]. Our measurements of longitudinal strain focused on individual evaluation of midwall deformations. Our results at baseline (GLS = -16. 1 ± 2. 7%) is consistent with the GLS observed in previous study  [34]. Other studies averaged the three layers of GLS  [11, 26] , but we chose to focus here on the middle layer considering that this GLS would be a good indicator of the association with radiation exposure in the LV wall in addition to the fact that it has been shown in several studies to be robust and reproducible  [24]. Further analysis detailing the three layers are in progress and may allow refining our results as previously observed for chemotherapy  [35].
Data collection The following data were collected: -socio-demographic data: age, sex, associated medical conditions such as penicillin allergy, smoking status, alcohol consumption, psychiatric disorder, immunodepression  [16]  (diabetes mellitus, obesity  [17] ,chemotherapy, HIV and hepatitis B or C infection, transplant surgery), asthma, non-mellitus diabetes -number and type of spaces involved by the infection -treatment on admission: ongoing antibiotic and/or anti-inflammatory treatment -duration of hospitalization and number of surgical procedures -bacteriological results, results of culture and sensitivity testing -antibiotic adaptation.
Data collection During the period of the study, 653 patients were enrolled: 386 (59%) were male and 267 (41%) female, with a mean age of 37 years (range 8 -88), 375 (57%) were smokers, 78 (12%) regular drinkers, 54 (8%) addicted to drugs, 23 (3. 5%) non-mellitus diabetics, 25 (3. 8%) immunosuppressed, 33 (5%) asthmatics and 62 (9. 5%) had psychiatric disorders. Forty seven patients (7. 2%) were allergic to penicillin. During surgery, 516 patients (80%) had a single facial space infected by pus, 95 (15%) patients 2 spaces, 28 (4%) patients 3 spaces, 5 patients (1%) 4 spaces and 1 patient had 6 spaces involved. The submandibular space 32% (n=209) and the vestibular space 28% (n=182) were the most frequently involved. A total of 378 (58%) patients had been receiving oral antibiotics before admission to hospital, for a mean duration of 4.
ACKNOWLEDGEMENTS Authors warmly thank  LHC Injector Upgrade  project management for their technical and financial support in the studies and test of new 3D Carbon/Carbon composite materials at  CERN. Authors express their recognition to  Ariane Group Company  for their deep collaboration in the implementation of specific production steps during the material procurement. Finally, acknowledgements to the  CERN High Radiation to Materials (HiRadMat) facility , and the  CERN Materials and Metrology section  and the  CERN Radiation Protection (RP) group  for their commitment and support in the characterisation of 3D Carbon/Carbon composite at CERN.
Funding: This research was funded by the  Institut National du Cancer ,  INCA-T 2012-2014 ; the  Association Laurette Fugain ,  ALF 2016/18 ; the  Fondation ARC pour la Recherche contre le Cancer , equipe labellisée 2017-2019. This work was also funded by the  French government (National Research Agency, ANR)  through the  "investissement for the future" LABEX SIGNALIFE program  reference # ANR-11-LABEX-0028-01.
Acknowledgements This work was supported by  EC Hydralab IV/ PISCES  project (Grant Number  261520 ) and by the  ANR   FlowRes  project (Grant Number  14-CE03-0010 ). M. Rouzes  benefited during his PhD from financial support by the  Direction Générale de l'Armement (DGA). The help in the experimental setup by  S. Cazin ,  M. Marchal  and  S. Font  is gratefully acknowledged. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. 0 International License (http://creat iveco mmons. org/licenses/by/4. 0/),which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
KPC and iMEF cells were co-seeded at 10,000 cells/well and 20,000 cells/well, respectively and grew into 3D spheroids in 800 μL medium using 24-well plates with cell repellent surface (Greiner Bio-One ® , Germany). Spheroids were left untouched during 3 days before any additional treatment (Fig. 7 ). image acquisition and spheroid characterization. Fluorescence microscopy images from spheroids were acquired using a confocal microscope Spinning Disk Leica ® DM6000 (Leica ® , Germany). MetaMorph ® software (Molecular Devices ® , USA) and ImageJ ® software (ImageJ ® software, NIH, USA) were used, respec- tively, for the acquisition and the analysis of images. Histological analysis was performed after spheroid fixation with 4% paraformaldehyde on 5 micron-thick paraffin sections. As previously described, intra-spheroidal nanoparticle clearance was near-complete after eight days of growth  30.
Cells were then marked with the BV-510 viability marker. FSC and SSC, providing green and red fluorescence signals at 530 and 650 nm, respectively, and BV-510 marker were evaluated for each cell. A total of 10,000 events were recorded for each tube. All experiments were performed four times with six dissociated KPCF spheroids per condition. Measurements were done under fixed instrument settings. Results were analyzed using Flowjo ® software (LLC, USA).
Instance generation We generate a set of 90 instances starting from two well-known benchmark instances, namely mt06 (taken from  Fisher and Thompson [1963] ) with 6 jobs and 6 machines, and la04 (taken from  Lawrence [1984] ) with 10 jobs and 5 machines, and extending them by adding machine power values, overall power consumption peak, timespan, period durations and electricity prices. Five sets of machine power values φ m are randomly generated from the uniform distribution U (5, 10). We denote the resulting datasets with DS1 φ to DS5 φ. For each dataset, we consider 3 different value of power peak W max = α • m∈M φ m , with α ∈ {0. 7, 0. 9, 1. 0}, and 3 different values of planning horizon duration C max = λ • C * max , with λ ∈ {1. 0, 1. 1, 1. 2}. C * max is the optimal makespan obtained by imposing the power limitation constraint and minimizing the makespan instead of the overall energy cost (as done e.
g. in Figure  3 ). As shown in Figure  8 , for each initial benchmark instance, we have 5 groups of instances, each descending from a machine power values dataset and counting 9 instances which differ in the values of parameters α and λ. Conversely, each result will be presented as the average value among the five instances which descend from the same benchmark and have same values of α and λ, i. e. that differ in the dataset they belong to. This allows to mitigate the effects of the random generation of φ m values. As to electricity prices, we consider for each instance a succession of ON/OFFpeak periods. Values are inspired by the French case (see EDF  [2017] ), where the duration of ON-peak periods is 16 hours with an electricity price of 0. 159 e/KWh, while the duration of OFF-peak periods is 8 hours and the electricity price is 0.
, 2011b). The characteristic interfaces (twin interface between neighbouring variants, and habit plane between austenite and martensite) were analysed using the indirect two-trace method  (Zhang et al. , 2007). The Miller indices of individual interface planes were determined according to the orientation data of adjacent crystals and the trace vectors of interfaces in the sample coordinate system. The strain accommodation of various variant combinations was evaluated based on the deformation gradient tensor of individual variants from austenite to martensite. The deformation gradient tensor was constructed by examining the atomic correspondences under the virtual orientation relationship between the two phases.