dataesr/scientific-paragraphs-categorization huggingface dataset:
Acknowledgments The authors gratefully acknowledge the financial support by  INRA   ACCAF Metaprogramme  ( CLIF  project) and  ARIMNET  ( PoH-MED  project;  KBBE 219262 ). The authors also warmly thank  E. Runno-Paurson  ( Tartu University, Estonia ),  B. Nielsen  ( Aarhus University, Denmark ), and  Z. Bouznad  ( ENSA Algiers, Algeria ) for the gift of some of the isolates included in this study,  Mathilde Bodiou  ( SYNTEC, Pleumeur-Gautier, France ) and  Loukas Kanetis  ( Cyprus University of Technology, Limassol ) for help with the sampling of French and Cyprus isolates. We are grateful to the  INRA Genetic Resources Center BrACy-Sol of Ploudaniel  for providing the plant material used in the tests. N. Mariette  is supported by  Ph. D. project cofunded by  INRA  and a  CIFRE grant  ( ANRT ,  French Ministry of Research)  supported by  ACVNPT  ( Association des Cr eateurs de Vari et es Nouvelles de Pomme de Terre ).
A constant heating ramp of 5 °C/min has been used. Structural characterization of TiVZrNbHf and (TiVZrNbHf)H x was performed with X-ray powder diffraction (XRD) with either a Bruker D8 Advance equipped with a Lynx-eye XE position sensitive detector using CuKα radiation or a Bruker D8 using a Johansson monochromator (CuKα 1 ) equipped with a Lynx-eye detector. The samples for diffraction were prepared by sieving powder onto zero background single crystal silicon sample holders. The structure of the sample as-synthesized was refined from the X-ray diffraction data using the Rietveld method 9 implemented in the FullProf 10 program. The background was taken by linear interpolation between selected points and pseudo-Voigt peak functions were used to describe the peak shapes. For the hydrogenated samples, lattice parameters were determined using the Bruker TOPAS software.
METHODS: Individual patient data were available on 10,553 patients enrolled onto 14 first-line randomized trials. Stratified multivariable Cox models were used. FINDINGS: There were 9,178 (87%) patients with non-peritoneal mCRC (4,385 with one disease site, 4,793 with ≥2 disease sites), 194 (2%) patients with isolated pmCRC, and 1,181 (11%) with pmCRC and other organ involvement. These groups were similar in age, race, and use of targeted therapy. Patients with pmCRC compared to those with non-pmCRC were more likely to be female (41% vs. 36%, p<0. 001), have colon primary tumors (84% vs. 66%, p<0. 0001), and have performance status 2 (10% vs. 6%, p<0. 0001). Higher proportion of mutated BRAF was seen among patients with peritoneal-only (8/44 cases with available data, 18. 2%) and pmCRC with other disease sites (34/289, 11.
Increased number of metastatic sites is a recognized negative prognostic factor in mCRC  6, 7. Peritoneal metastases are associated with increased number of metastatic sites in mCRC patients. 1 erefore, it is unclear whether worsened prognosis of pmCRC patients is due to its association with more widespread metastases or an inherent feature of pmCRC. Additionally, relative prognosis of patients with peritoneal-only involvement as compared to other isolated disease sites (e. g. liver-only) has been understudied. 4  utilized the ARCAD Foundation (Aide et Recherche en Canérologie Digestive) database of pooled individual patient data from randomized studies of advanced colorectal cancer  8  to investigate effect of peritoneal metastases on outcomes among mCRC patients treated on firstline systemic chemotherapy trials.
M E T H O D S We included individual patient data from first-line prospective controlled randomized phase III trials treating patients with metastatic colorectal cancer. The ARCAD colorectal cancer database integrates individual patient-level data from a large collection of clinical trials for the purpose of endpoint evaluation and development, as well as variety of prognostic studies. We considered only trials which protocols explicitly pre-specified and solicited for peritoneal involvement in the trial data collection process or a formal peritoneum-focused review of individual pre-treatment scans was performed (CAIRO studies). Patients were excluded if disease sites were unknown. The presence of ascites was not considered as evidence of peritoneal involvement for the purpose of this analysis.
Stratified multivariable Cox models were used to assess the prognostic associations of pmCRC with OS and PFS, adjusting for other key clinical-pathological factors (age, gender, WHO performance score, primary tumor location [colon vs. rectum], prior treatment, and baseline body-mass index [BMI]). KRAS status was used to further stratify patients who received anti-EGFR therapy (i. e. , cetuximab). Analyses were performed using SAS version 9. 2 (SAS Institute, Cary, NC) and R version 2. 11 (http://www. r-project. org). Two-sided p-values of less than 0. 05 were considered to be significant and were not adjusted for multiple comparisons.
R E S U L T S Fourteen first-line randomized trials (5 of which tested targeted regimens, Table  1 ) in the ARCAD database solicited data collection of peritoneal metastasis and provided individual patient data for total of 10,635 patients. Metastatic sites data were available on 10,553 patients and 82 patients with absent disease site data were excluded. Non-targeted cytotoxic agents only were used in 8,185 (77. 6%) patients, and 1,568 (14. 9%) and 1,037 (9. 8%) received antiangiogenic and anti-EGFR agents, respectively (237 of these patients received both antiangiogenic and anti-EGFR targeted therapy). Overall, 63% of the patients were male, the median age was 64 years, 94% of the patients had ECOG performance status of 0-1, and 68% presented with a colon primary tumor; Table  2. There were 9,178 (87%) patients with non-peritoneal mCRC (4,385 with one disease site; 4,793 with ≥2 disease sites), and 1,375 patients with peritoneal metastases (194 patients with isolated pmCRC; and 1,181 with pmCRC plus another disease site(s)).
The present analysis differs in conclusion from that provided by the only prior study investigating peritoneum-only metastatic involvement  4. We observed that patient prognosis with peritonealonly metastases was similar to those with two non-peritoneal disease sites (both M1b stage), while the other report suggested that peritoneal-only involvement carries prognosis similar to other isolated disease sites, and better as compared to multiple disease sites. It is likely that a larger patient sample and better data collection in context of randomized trials are primarily responsible for better discrimination in our study. Strengths of the present report are its large sample size and superior data quality. Individual patient data were collected from prospective randomized studies that solicited for peritoneal involvement (peritoneal involvement was specified in the on-study data collection form) or a peritoneum-specific review of pretreatment scans was conducted.
The effect of the increase in Pi absorption on biomass was also investigated. Rosette weight of in vitro plantlets was increased in all three complemented lines (as compared to the phf1-1 mutant, Figure  3C , Figure  3C -source data 1) after transfer from Pi-depleted to Pi-rich medium during 4 days. The root cap complementation restored 40% of the growth (phf1Q0171>>PHF1 and phf1J1092>>PHF1 lines) and in agreement with the full restoration of Pi uptake similar to the WT control, the phf1J0481>>PHF1 line does not present any growth defects. To investigate the long term effect of the root cap complementation, we first grew plants on sand (hydroponically with 10 mM Pi supply) for 3 to 4 weeks; the experiment was terminated at the appearance of the first stem. The rosette biomass of the phf1Q0171>>PHF1 line (in which complementation was restricted to the root tip) exhibited a significant 80% increase in rosette biomass, as compared to the phf1-1 mutant (Table  1 , Table  1 -source data 1).
Real-time imaging of phosphate uptake Seven-day-old plantlets grown in -P medium were transferred to glass slides covered with 0. 1% agar, containing 1 mM Pi solution supplemented with 33 P (200 kBq/10 mL). Real-time imaging of 33 P uptake was performed using the Imaging System as described above. Images were acquired after 1 to 10 min, and radioactive signal was quantified using the AQUACOSMOS software (Hamamatsu Photonics; Japan) on a selected root tip zone (0. 2 mm). A separate labeling procedure was used to quantify a broader part of the root (2 mm). Roots of 7-day-old plantlets were immersed in 1 mM Pi solution containing 2000 kBq 33 P for 1 min. Samples were then rinsed in a solution containing 1 mM 2,4-dinitrophenol. This inhibitor of ATP production was used to block cellular metabolic activity and to prevent ionic movement (including 33 Pi).
Acknowledgements We thank  Drs. T Desnos  and  N Leonhardt  for valuable suggestions and their kind revision of the manuscript,  N Pochon-Brousse  and  S Deschamps  for technical support and  B Loveall of Improvence  for language correction services. Lines were gratefully provided by  Drs. L Laplaze  (enhancer traps),  V Rubio  (PHF1:GFP),  A Leyva  (proPHT1;1:LUC) and  J Paz-Ares  (phf1-1 mutant). We thank  C Sarrobert  and  C Latrille  for providing the soil analysis and the GRAP team for plant culture assistance. This work was supported by funding from the  French CEA  (LN, MCT, SC, JFA, VB, HJ, ED, EM, SK), a  Marie Curie International Reintegration grant  from the 7th  European Community Framework Programme (HJ) ,  PIA-RSNR , DEMETERRES from the  French government (MCT, LN) , the  Japan Society for the Promotion of Science (SK) , the  University of Tokyo  (TN, SK), and the  ANR   REGLISSE  project (LN, MCT).
Stimuli and apparatus The virtual visits took place in two kind of houses: furnished and unfurnished. For the first type, houses were furnished with sofa, tables, chairs, beds, bedside tables, wardrobes. For the second type, rooms were empty and only basic elements were present such as a toilet, shower, washbasin and doors. Virtual houses were reproduced from real floorplans. All houses were at scale 1:1 and the size of the walls was between 2 and 7 m. Houses were modeled using 3DMax software, with simple textures. Realistic lighting was precomputed to avoid latency. This experiment took place within the virtual reality platform In Virtuo of our laboratory. The VE was displayed on large screen (3 m X 2. 25 m), with monoscopic vision and without head-tracking. For the navigation, we used the Ninento Wiimote as interaction device.
002, p = 0. 967) and the furnishing condition (see table 2: F(1,36) = 0. 030, p = 0. 863) on habitability. However, we found a significant interaction effect between the furnishing condition and the projection (F(1,36) = 4. 674, p = 0. 045) on habitability, as illustrated in figure  8. This interaction suggest that we should ignore the absence of main effect of the factors, and investigate the simple main effects of our independent variables separately. Thus, we divided our dataset along each level of our projection variable and ran an ANOVA investigating the impact of furnishing condition on habitability (at a. 025 level of significance, to take into account the multiple ANOVA). We found that the furnishing condition has a significant impact on habitability for the perspective projection (F(1,18) = 7.
Collected data Demographic and clinical data at first dialysis were extracted. Three demographic variables were taken into account: age group (18-39, 40-59, 60-69 and 70-80 years), gender and region of residence. The following patients' clinical features at first dialysis (baseline) were studied: primary renal disease categorized in six groups [glomerulonephritis, pyelonephritis, diabetic nephropathy, hypertensive and vascular nephropathy, polycystic kidney disease and others (other causes and unknown)], modality and type of first dialysis (haemodialysis or peritoneal dialysis, emergency first dialysis and first dialysis session with a catheter), cardiovascular diseases (coronary artery disease, congestive heart failure, peripheral vascular disease, myocardial infarction, arrhythmia, aortic aneurism, cerebrovascular disease), diabetes, chronic respiratory disease, hepatic disease, active malignancy, physical disabilities (ambulation impairment, paraplegia or hemiplegia, member amputation, blindness) and HIV infection.
Statistical analysis The patients' characteristics were described and compared using Pearson's χ 2 test. Continuous variables were expressed as mean ± standard deviation. Means were compared using a Student test and medians using a non-parametric equality-of-medians test. Missing data were systematically imputed using multiple imputation by chained equation (MICE) with 10 imputations and one cycle, because missing data concerned only the haemoglobin level  [21]. The outcomes of interest were 1. Placement on the renal transplant waiting list, regardless of the donor type (living or deceased). Death before waitlisting was considered as a competing event. Patients pre-emptively placed on the list before the beginning of dialysis were considered to be waitlisted at dialysis start. Times to outcomes (death, waiting-list placement) were calculated from the date of first dialysis.
Variables with a P-value <0. 20 were included in the multivariate analysis. A Pvalue <0. 05 was considered statistically significant. Results were reported as subdistribution hazard ratios (SHRs) with 95% confidence intervals (CIs) and P-values. The cumulative incidence function (CIF) curve, which represents the probability of transplantation after taking into account the competing risk of death before transplantation and living donor transplantation, was also used to compare the two regions. Statistical analyses were performed with STATA 13 software.
Acknowledgements This work is supported by the  Agence Nationale de la Recherche  in the framework of the  Investment for the Future program  ( ANR-11-IDEX-0005-02 ). The authors thank  Dr Cécile Couchoud  and  Dr Christian Jacquelinet  ( Agence de la Biomédecine ) for data extraction and for providing Supplementary data, Table S1 summarizing the French kidney allocation scheme. The authors thank also  Laura Milne  for English revision.
14, -0. 82, -1). This safety check, to verify that the new microstructure belongs to the manifold making possible further calculations, in particular the temperature fields interpolation, was carried out in about 0. 3 seconds in a standard laptop using Matlab. The interpolation itself was performed in about 6 milliseconds. Both thermal problems were then solved in order to evaluate the accuracy of the interpolated fields, and the errors were again quite small, of around 10 -3.
MATERIALS AND METHODS The Ethics Committee of the French Society of Thoracic and Cardiovascular Surgeons approved this study (Agreement number: CERC-SFCTCV-2016-2-29-16-57-5-ReSt). The studied population was a part of a cohort published elsewhere and consisted of 841 patients who received NSCLC surgery with curative intent in the Department of Thoracic Surgery at Strasbourg University Hospital (France), from January 2007 to December 2012  (Renaud et al, 2015b). We focused on the 481 patients who experienced thoracic or extra-thoracic recurrence and metastasis after surgery. Molecular analysis, neo-adjuvant and adjuvant treatment regimens, pre-operative staging and thoracic surgery procedures were performed as previously published  (Renaud et al, 2015b). Covariates and data collection. Baseline patient characteristics were collected, including age, sex, smoking history, and history of neo-adjuvant and adjuvant therapy.
The date of recurrence or metastases was defined as the first radiographic evidence of cancer relapse upon imaging and/or pathological tumour evidence from a biopsy. The TTR was defined as the time from surgery until the first diagnosis of recurrence or metastasis upon imaging or from biopsy specimens. Statistical analysis. IBM SPSS (Armonk, NY, USA) v. 20 was used for statistical analyses. Comparisons between groups were performed with w 2 , Fisher or Student's t-tests as appropriate. Cramer's V was used to evaluate correlations between qualitative variables. A multivariate analysis with stepwise logistic regression to predict the first site of recurrence or metastasis was performed for P-values o0. 2 in the univariate analysis. All tests were twosided, and the results were considered significant for P-valueso0.
0001). Six patients (1. 3%) were diagnosed with both lung and other organs metastasis, and were included in the 'lung group'. Data are compiled in Table  3. Data regarding the variables used to predict the recurrence site or metastasis in the univariate analysis are presented in Table  4. Bone metastasis. A total of 118 patients (25%) experienced bone metastasis as the site of first recurrence. In the univariate analysis, the risk of bone metastasis was higher in patients with G12C mutations compared to all patients in the remainder of the cohort (odds ratio (OR): 7. 434 (95% CI: 4. 524-12. 217), Po0. 0001). Specifically, 59% of G12C patients experienced a bone metastasis as the first site of recurrence, compared with 16% of patients in the remainder of the cohort (Po0. 0001). In addition, angio-invasion (OR: 0.
4) with a z step of 1 µm and a frequency of 400 Hz. 3D projections were generated with the Easy 3D IMARIS function (Bitplane, Zurich, Switzerland). Biofilms structural parameters [biovolume (µm 3 ), mean thickness (µm), and roughness (µm)] were extracted from image series using the PHLIP Matlab routine 2. Each value presented is the average of six image series acquired in three independent experiments.
25 mol/l in 45% v/v methanol solution for 10 min at 80 • C;  Méchin et al. , 1999). Fatty acid methyl esters were extracted with a diethyl ether/cyclohexane solution (1:1 v/v). The organic phase was at the end washed with a dilute base (NaOH 0. 3 mol/l). Analytical gas chromatography of fatty acid methyl esters was carried out on a 6890HP system (Agilent Technologies, Santa Clara, CA, USA) equipped with a DB5 capillary column (Agilent Technologies, Santa Clara, CA, USA) and a flame-ionization detector. Column temperature was set at 150 • C for 4 min and then increased to 250 • C at the rate of 4 • C/min. Data were acquired using a HPCORE ChemStation system (Agilent Technologies, Santa Clara, CA, USA) and expressed as a percentage of the total area. Fatty acids were identified using fatty acid methyl ester standards and grouped in classes: saturated fatty acids (SFA), unsaturated fatty acids (UFA), hydroxylated fatty acids (HFA), cyclopropane fatty acids (CFA), branched-chain fatty acids (BCFA).
1, 2, 4 However, despite the advice to avoid pregnancy,  3, 5  some women with PH choose to become pregnant or to continue with an unplanned pregnancy. Owing to the absence of larger (>20 cases) prospective outcome studies on PH in pregnancy, many questions remain unanswered. The aim of the present report was to investigate maternal and fetal outcomes in women with PH, including all subtypes of PH, according to the most recent guidelines  6  and to document the outcomes in the different subpopulations. The specific impact of comorbidities, type of anaesthesia, mode of delivery, and medication were evaluated, as well as the risk of developing heart failure and thrombotic events in the mother. The data were collected by the European Registry Of Pregnancy and Cardiac Disease (ROPAC). This registry was initiated by the European Society of Cardiology (ESC) in 2007.
Study design A detailed description of study design and data collection was reported previously. 7 ROPAC is an ongoing worldwide registry that includes all pregnant women with congenital and structural heart disease. Patients with arrhythmic disease in the absence of structural heart disease are excluded. Prospective inclusion of patients commenced in January 2008, and this interim analysis concerns patients enrolled between January 2008 and April 2014. For the present study, outcomes of pregnancy were analysed for patients with PH. All patients with right ventricular systolic pressure (RVSP) >30 mmHg at rest, measured by echocardiography or right heart catheterization, were included. Patients with elevated RVSP caused by outflow tract obstruction/pulmonary stenosis were excluded.
Data Information was collected regarding age, parity, cardiovascular risk factors, type of heart disease, aetiology of PH, previous interventions, New York Heart Association (NYHA) functional class,  8   cardiac events such as heart failure or arrhythmias, obstetric events such as pre-eclamptic toxaemia or postpartum haemorrhage, timing and mode of delivery, neonatal sex and birth weight, and postpartum events. Follow-up data included vital status, cardiac events and neonatal status. Follow-up was available in all patients up to 1 week. If available, follow-up was reported up to 6 months. Information on pulmonary hypertension was collected via the following ROPAC Registry website CRF variables: under echocardiographic assessment the value of peak velocity tricuspid regurgitation, as well as RVSP could be entered; RVSP could be entered via a tick box in the following categories of <30, 30-50, 50-70, 70-90, and >90 mmHg or unavailable; among the parameters for the cardiac function the right ventricular function could be entered as normal, moderately impaired and severely impaired.
The question of whether full right heart catheterization confirming PH via standard criteria was performed before pregnancy, could be answered with either a yes (26%) or no. No other parameters such, for example, cardiac output, or pulmonary vascular resistance, were collected in this database. Pregnant women were categorized based on their PH aetiology, as classified in the most recent consensus document. 9 Patients with PAH in case of iPAH, CHD-PAH or oPAH caused by diseases such as connective tissue disease or vascular malformations were classified as group 1. Patients with PH caused by left heart disease (LHD-PH) with left ventricular systolic dysfunction, valvular disease or congenital/acquired left heart inflow or outflow tract obstructions or congenital cardiomyopathies were classified as group 2.
Statistical analysis Baseline characteristics, as well as cardiac, obstetric and fetal outcome are presented for the total PH group. We compared baseline characteristics and outcome of PH in group 1 and group 2. Categorical data are presented as frequencies and percentages, and chi-square tests were used for comparison. If there were less than five cases in a group, Fisher's exact test was used. Normality of continuous data was checked with Kolmogorov-Smirnov tests and presented either as mean ± standard deviation, or as median and first and third quartiles (Q1-Q3) as appropriate. Differences between groups were assessed using Student's t-tests or, in case of non-normality, using Mann-Whitney tests. P-values were considered statistically significant if less than 0. 05 (two-sided test). All analyses were performed with SPSS 21.
This team will also prepare a delivery plan, balancing the advantages of vaginal birth (lower blood loss, lower risk of infection, and thrombus formation) vs. CS (better haemodynamic monitoring). The 2015 ESC/European Respiratory Society (ERS) guidelines for the diagnosis and treatment of pulmonary hypertension,  6  as well as the ESC guidelines on cardiovascular disease in pregnancy,  3  state that pregnancy in all women with PH should be avoided or terminated early. Our data suggest that such advice should be focused on the high-risk subgroups, namely those with PAH. However, should pregnancy occur, very close expert follow-up is needed with at least monthly review. Serial echocardiography should be used to screen for right heart failure. Overall, little is known about the outcome of PH in the peripartum period.