dataesr/scientific-paragraphs-categorization huggingface dataset:
All of these bad exposures were removed from the data set, and coadds were remade without them. This visual scan procedure was as follows. First, we displayed the full coadd tile at a scale that permitted us to notice macroscopic problems, but not with a resolution to notice SL systems. Then we "zoomed-in" at a dozen or more different places on the coadd tile, looking for problems that could only be seen with finer resolution. See Figure  4. In this process we viewed only a fraction of the area of the tile, perhaps one-tenth, with sufficient resolution to spot a candidate SL system. We recorded 44 candidates for the short list. Seventeen of these were graded as rank 3 or more.
Lens and source images were matched to catalog object IDs. Y6 object identifications were preferred over Y3; however, in cases where an object was not detected in Y6, or was blended with another object, the object was matched to the Y3 catalog. Within each system, catalogs were kept consistent, such that no system mixes Y3 data for some objects with Y6 data for others. Some source images could not be accurately associated with a known DES object, and their position was estimated manually. Table  4  shows the positions and photometry for all systems presented in this paper. We identified those systems presented here that were previously known, as well as those that are new. To do so, we checked the candidates against the Master Lens Database  (Moustakas et al. 2012) , the list of objects labeled as strong lens candidates or known systems in SIMBAD  (Wenger et al.
2000) , and other SL search papers. Previous discoveries of all systems are given in Table  3. Note that references include both confirmed and candidate strong lens systems, i. e. systems with external references are not guaranteed to be true lenses. We include these previously discovered systems in this work because we provide positions, photometry, and photometric redshifts of system components (see Table  4 ), as well as an estimate of the Einstein radius (see Table  3 ), forming a standardized dataset which may be of use in further studies. The average radius of source images is an approximation for the Einstein radius, and is identical to that when the true source position is directly behind the lens. We estimate the Einstein radius from the mean separation between the primary lens and each source image.
SUMMARY AND CONCLUSION We report the results of eight searches for strong gravitational lens candidates in the full 5,000 sq. deg. footprint of the DES imaging data. We searched the DES catalogs for spatial matches of potential lens and source candidates using the "Blue Near Anything" and "Red Near Anything" algorithms. We searched the positions of known ACT, SPTPol, and DES redMaPPer galaxy clusters. The scanning of wide-area tiles for the DES data quality effort led to serendipitous discovery of several SL systems. For all of the searches we produced a short list of candidates and then evaluated cutouts to identify the most promising systems based on color and morphology. We then assigned those a rank that quantifies our confidence that the system is a potential strong gravitational lens.
ACKNOWLEDGEMENTS This research has made use of the NASA/IPAC Extragalactic Database (NED) which is operated by the  California Institute of Technology , under contract with the  National Aeronautics and Space Administration. Some figures in this work were generated with matplotlib (Hunter 2007). Funding for the DES Projects has been provided by the  U. S. Department of Energy , the  U. S. National Science Foundation , the  Ministry of Science and Education of Spain , the  Science and Technology Facilities Council of the United Kingdom , the  Higher Education Funding Council for England , the  National Center for Supercomputing Applications  at the  University of Illinois at Urbana-Champaign , the  Kavli Institute of Cosmological Physics at the University of Chicago , the  Center for Cosmology.
3c , left panel). This result indicates that the expression of HLA-E at the surface of T cell successfully inhibited the cytolytic activity of NK cells. HLA-E(+) T cells were also enriched among HLA-ABC(-) T cells when the CD123 tool CAR was substituted for a CD22 tool CAR (about a threefold increase, ΔTRAC CAR123 ΔB2M and ΔTRAC CAR123 ΔB2M HLAE , Fig. 3c , right panel), confirming the protective role of HLA-E against NK-cell activity and demonstrating the transposable nature of this feature. It is to be noted that the values of the HLA-E(+)/HLA-E(-) ratio is more dispersed in the dataset for CD123 CAR, possibly due to a larger dataset (8 points vs. 4 points) where the variability in the cytolytic activity of NK cells is more likely to be observed from donor to donor. To further confirm that HLA-E expression efficiently protects HLA-ABC-deficient T cells from NK-cell attack, we next engineered T cells to obtain optimal HLA-ABC inactivation and HLA-E expression (Fig.
Indeed, we observed conventional expression of CD56, NKG2A, KIRs, CD57, and of the triggering receptors NKp30, NKp46, and NKG2D (Fig. 5d ). These triggering receptors were markedly more prevalent in NKG2C(+) NK cells than in NKG2C(-) NK cells, used here as a control subpopulation. The NKG2C(-) control subpopulation was altered in newly diagnosed AML patients, as evidenced by the lower expression of NKP30, NKP46, and NKG2D activating receptors compared to healthy donors (Fig. 4c , left panel; compare the density plots of a healthy donor and AML patients). This trend was consistent with a former report  33  , validating the robustness and reproducibility of our dataset. Finally, we observed no difference in the intrinsic fitness and maturation profile of NKG2C(+) cells in both AML and ALL cohorts after chemotherapy, suggesting that NKG2C(+) NK cells lack the classical changes described in individuals undergoing chemotherapy (Fig.
HLA-ABC(-) HLA-E (+) 58% frequency of TCRαβ(-) HLA-ABC(-) T cells expressing CAR and HLA-E. This engineering strategy is compatible with standard universal CAR T-cell production processes that already includes TCRαβ(+) T-cell depletion, does not require any HLA-E (+) CAR T-cell enrichment or antibiotic-dependent selection step and thus, appears suitable for clinical product manufacturing. Co-treatment of T cells with TRAC and B2M TALEN did not result in significant off-site cleavage activity. This was demonstrated by an unbiased OCA assay and high-throughput DNA sequencing. As expected, this co-treatment induced translocations between Chr14 and Chr15, to an extent similar to the one reported previously with different gene-editing tools  2, 25, 51, 52. A search of gene fusion databases, including the Atlas of Genetics and Cytogenetics in Oncology and Hematology, did not show any record of pathogenic translocation between the TRAC and B2M loci (14q11 and 15q21.
We did not observe CAR expression at the B2M locus (Supplementary Fig. 1c , TLA sample 4), but we did find low but detectable expression of HLA-E at the TRAC locus (Supplementary Fig. 1c , TLA sample 2). Although we do not envision critical adverse events related to HLA-E expression by the TRAC locus, this dataset points out one of the limitations of this multiplex gene-editing strategy that must be considered in the development of other cell therapy products. It is noteworthy that this AAV6-mediated insertion approach was markedly more specific than random transgene insertion mediated by lentivirus particles (Supplementary Fig. 1c , TLA sample 8). We further report that efficiently targeted insertion of HLA-E m at the B2M locus leads to a robust HLA-E surface expression that inhibits the cytolytic activity of NK cells.
PBMCs from ALL and AML patients were obtained from the HEMATOBIO cohort (NCT02320656). PBMCs were cryopreserved in 90% albumin/10% DMSO. Samples of human origin and associated data were obtained from the IPC/CRCM/UMR 1068 Tumour Bank, that operates under the authorization # AC-2007-33 granted by the French Ministry of Research (Ministère de la Recherche et de l'Enseignement Supérieur). Prior to the scientific use of samples and data, patients were appropriately informed and asked to consent in writing, in compliance with French and European regulations. The project was approved by the IPC Institutional Review Board (Comité d'Orientation Stratégique, COS) as well as the Committee for the Protection of Persons South Mediterranean I (#2013-AO1437-38). Cell lines. MOLM13-nanoLuc-GFP and RAJI-Luc-GFP were engineered out of MOLM13 and RAJI cells (DSMZ, cat# ACC 554 and ATCC, cat# CCL-86, respectively) using an in house rLV encoding NanoLuc_T2A_EGFP construct and AMSbio cat# LVP323-PBS, respectively, using the manufacturer's protocols.
This error rate varies depending on the sequencing run and on the sequence itself. To quantitatively assess this error rate, sequencing datasets from 647 TALEN assayed against non-relevant targets (TALEN-transfected) were retrieved from our internal database, as were the corresponding controls performed without TALEN (mocktransfected). The difference in indels frequency between the TALEN-treated samples and the control samples was computed for each dataset. These differences followed an approximately Gaussian distribution with a mean (m) of 0. 0095%, and a standard deviation (σ) of 0. 04922%. We defined an off-site candidate as confirmed when the difference in indels frequency of the TALEN-and Mocktransfected T cells was larger than a threshold (T) defined as T = m + 3 σ = 0. 16%. Detection of translocations generated by simultaneous TRAC and B2M TALEN treatment in the presence or absence of CAR m and HLA-E m AAV6 matrices.
Cells were then analyzed using flow cytometry. Data were expressed as the ratio of HLA-E(+) to HLA-E(-) subpopulations among remaining HLA-ABC(-) ΔTRAC CAR ΔB2M T cells (i. e. , the frequency of HLA-E(+) T cells among total HLA-ABC(-) T cells/the frequency of HLA-E(-) T cells among total HLA-ABC(-) T cells). In vitro expansion and activation of NK cells used in the serial killing assay. To perform an in vitro serial killing assay in the presence of NK cells (see below), a large-scale activation and expansion of NK cells were set up according to the following method. After thawing, cryopreserved purified human CD56 + NK cells, negatively selected (AllCells) (5 × 10 6 cells) were resuspended at 1 × 10 6 cells/mL in expansion NK MACS medium (NK MACS medium supplemented with 1% NK MACS supplement (Miltenyi Biotec), 5% human AB serum, IL-2 (500 IU/mL), and IL-15 (140 IU/mL)).
Prior to surface staining, cells were stained with Fixable Viability Dye eFluor 450 or eFluor 780 (eBiosciences) according to the manufacturer's instructions. The cells were then stained with antibodies diluted in FACS buffer (4% FBS + 5 mM EDTA + 0. 05% azide in PBS, 20 μL/well) for at least 15 min in the dark at 4 °C. Cells were washed with PBS (150 μL/well), spun at 300×g for 2 min, and resuspended in fix buffer (4% paraformaldehyde in PBS, 100 μL/well). Sample collection was performed on a Macs-Quant (Miltenyi), FACSCanto II cytometer (BD) or NovoCyte Penteon flow cytometer (Agilent), and data were analyzed using FlowJo V. 10. 6. 1 (Treestar). Mouse models. All procedures involving animals were approved by The Mispro Institutional Animal Care and Use Committee and were performed e in accordance with the guidelines of the PHS (Public Health Service) Policy on Humane Care and Use of Laboratory Animals, OLAW (Office of Laboratory Animal Welfare), and the USDA (United States Department of Agriculture) AWA (Animal Welfare Act).
Disease progression was monitored on a weekly basis by in vivo bioluminescence imaging starting at day 15. Mice were intraperitoneally injected using a XenoLight D-luciferin (PerkinElmer, 200 μL/mouse, 15 mg/mL stock solution) prior to data acquisition. All live imaging was performed on Spectrum-CT apparatus (PerkinElmer) and Living Image software (Caliper). The endpoint was defined as the presence of ≥20% weight loss, hind limb paralysis, labored respiration, or inability to eat/drink. Average radiance was determined on dorsal and ventral settings, averaged, and plotted as a function of time to depict tumor growth. In vivo enrichment of ΔTRAC CAR ΔB2M HLAE in hIL-15 NOG mice engrafted with human PBMCs. To assess the persistence of ΔTRAC CAR ΔB2M HLAE T cells in vivo, cryopreserved human PBMCs acquired from ALLCELLS (cat # PB006F) were thawed as described above.
Sample collection was performed on FACSCanto II cytometer (BD Biosciences) and data were analyzed using FlowJo v10. 6. 1 (Treestar). Mass cytometry analysis of NK cells from AML, ALL, and healthy donors. PBMCs were processed as previously described with slight modifications  33. PBMCs were thawed and washed with RPMI 1640 medium supplemented with 10% fetal calf serum (FCS) and incubated in RPMI 1640 with 2% FCS and 1/10000 Pierce ® Universal Nuclease 5kU (Thermo Fisher Scientific, Waltham, MA, USA) at 37 °C with 5% CO 2 for 30 min. Cells were incubated with cisplatin 0. 1 M to stain dead cells. Nonspecific epitopes were blocked using 0. 5 mg/mL Human Fc Block (BD Biosciences, San Jose, CA, USA). PBMCs were stained for 45 min at 4 °C with a mix of extracellular antibodies (see Supplemental Table  7 ) and barcoded with the Cell-ID™ 20-Plex Pd Barcoding Kit (Fluidigm, San Francisco, CA, USA) according to the manufacturer's recommendations.
Algorithm-based high-dimensional analysis. NK cells were manually defined as CD13-CD33-CD34-CD45 + CD3-CD19-CD56 + and exported using FlowJo V10. 6. 2. Consensus files were generated for NKG2C(+) NK cells and NKG2C(-) NK cells from healthy volunteers and AML or ALL patients with a fixed number of NK cells. Data were arcsinh-transformed with a cofactor of 5. NK-cell populations were automatically defined using the optimized parameters for T-distributed stochastic neighbor embedding (opt-SNE) algorithm. The frequency of each NK cell subpopulation (among total lymphocytes as well as lymphocytosis (G/L) was used to determine the absolute counts of NK-cell subsets using the total cell number per volume unit obtained for each patient. Functional characterization of the cytolytic activity of AML patients, healthy donor PBMCs toward ΔTRAC CAR ΔB2M HLAE.
Acknowledgements We would like to thank the generous contribution of all the patients involved in this study. We would like to thank  Jean Charles Epinat  and  Enda Shelvin  for their contribution in the revision of this manuscript. D. O. team was funded, in part, by  "Equipe FRM   DEQ20180339209 ". D. O. is Senior Scholar of the  Institut Universitaire de France (France). The team Immunity and Cancer led by D. O. was labeled by the  "Fondation pour la Recherche Médicale" (France).
5 µg (two doses twice daily) for 28 days in addition to standard care versus standard care alone NCT05054322 [82] FLOT Fluticasone propionate 125 µg with Primary Incidence of adverse outcomes 500 September 2021 January 2022 Vietnam spacer (four puffs twice daily) care (oxygen therapy, systemic for 14 days in addition to corticosteroids, hospitalisation, standard care mechanical ventilation and mortality) in symptomatic patients at 28 days after study inclusion.
Observation and Data Analysis In order to investigate further the X-ray flux from Cepheids, observations of two stars (l Car and and Polaris) were made with Chandra. The observations were timed exposures with the ACIS-I instrument and are listed in Table  1. Reductions were done with the standard CIAO software package. 11  Car. -The long-period Cepheid l Car is known to have period fluctuations like other long-period Cepheids  (Anderson 2016; Anderson et al. 2016). The phases of the observations were computed from the period summary in  Neilson et al. (2016) , including the changing period. The time of observation was selected based on the relation between maximum radius and the burst of X-rays in δ Cep, where the X-ray burst occurs approximately 0. 1 in phase after maximum radius. The phase of maximum radius has been measured in three  successive cycles by  Anderson et al.
910+3. 972433 E. The phase range covered by the observation is 0. 48-0. 69. A source was detected at the position of Polaris. A flux was determined by fitting the spectrum with a MEKAL model in CIAO with E(B -V ) = 0. 00 and a fixed temperature of 0. 56 keV, typical of a young star. MEKAL models were used for consistency with data from  Engle (2015) ; however, tests with newer APEC models agreed to 10%. The resulting flux is 2. 08 × 10 -14 erg s -1 cm -2. The distance used to determine the luminosity is 137 pc from the Gaia EDR3 distance to the resolved companion Polaris B. Because of the length of the exposure, the luminosity was computed for two halves, log L X = 28. 83 and 28. 71 [erg s -1 ]. The details are listed in Table  1.
This research is based on observations obtained with  XMM-Newton , an  ESA  science mission with instruments and contributions directly funded by  ESA Member States  and the  USA (NASA). Support was provided to NRE by the  Chandra X-ray Center NASA  contract  NAS8-03060. The observations were associated with program 84051, with support for this work from  NASA  grant  80NSSC20K0794. J. J. D. was supported by  NASA  contract  NAS8-03060  to the Chandra X-ray Center and thanks the director,  Pat Slane , for continuing advice and support. H. M. G. was supported through grant  HST-GO-15861. 005 -Afrom the  STScI  under  NASA  contract  NAS5-26555. P. K. and L. B. acknowledge funding from the  European Research Council (ERC)  under the European Union's  Horizon 2020 research and innovation program  (projects  CepBin , grant agreement No.
695099 , and  UniverScale , grant agreement No. 951549 ). This work has made use of data from the  European Space Agency (ESA) mission Gaia  (http://www. cosmos. esa. int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, http://www. cosmos. esa. int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. The SIMBAD database and  NASA 's Astrophysics Data System Bibliographic Services were used in the preparation of this paper.
Basal dimensions of bovid horn cores are reported as anteroposterior and transverse (AP × TR) diameters. Horn core torsion, if present, is described as either homonymous or heteronymous: homonymous torsion is clockwise on the right side from the base up, whereas heteronymous torsion is anticlockwise on the right side from the base up (as in Tragelaphus). A complete list of specimens and measurements is provided in Data S1. All measurements were taken with digital calipers and are reported in millimeters (mm). Dental abbreviations used for systematic paleontological descriptions are as follows: Incisors are indicated by I or i, premolars by P or p, and molars by M or m, with uppercase letters referring to upper teeth and lowercase letters referring to mandibular teeth. Numbers 1, 2, 3, and 4 indicate tooth position (e.
Turnover and paleoecological analyses We compiled a presence-absence database of Hadar Formation, Ledi-Geraru, and Maka'amitalu herbivores  (Artiodactyla, Perissodactyla, Proboscidea)  to analyze turnover and paleoecological change through time (Data S1). We focused our analyses on herbivores because they are abundant and most are large-bodied, meaning that they are unlikely to be impacted by the taphonomic and collection biases affecting the recovery of rare or small-bodied taxa  (Behrensmeyer, Kidwell & Gastaldo, 2000). As primary consumers, they also directly reflect vegetation composition and other key ecosystem characteristics  (Greenacre & Vrba, 1984; Fortelius et al. , 2016). We divided the lower Awash sequence into submember and fault block units following  Campisano & Feibel (2008a) and DiMaggio et al.
(2015) , except for the adjacent Sidi Hakoma 4 (SH-4) and Denen Dora 1 (DD-1) submembers of the Hadar Formation; these units were analyzed as an aggregate (SH-4/DD-1) because they interdigitate across the Hadar outcrops and represent similar depositional environments. Turnover Analyses-Patterns of taxonomic turnover between adjacent fossil units were quantified using the pairwise Simpson dissimilarity (β sim ) measure in the betapart package  (Baselga & Orme, 2012 ) in R v. 4. 1 (R Core Team, 2021). β sim is calculated as b sim ¼ min b; c ð Þ a þ min b; c ð Þ where a is the number of species common to both units, b is the number of species that occur in the first unit but not in the second, and c is the number of species that occur in the second unit but not the first. We chose β sim as our turnover measure because it quantifies species replacement independent of species richness  (Baselga, 2010) , which is variable in the lower Awash sequence.
For turnover analyses we treated open nomenclature as follows: all records indeterminate at the species level were removed unless they were argued by taxonomic experts to represent distinct species (e. g. , Kobus sp. B of  Gentry (1981) ). We lumped 'cf. ' species records with their probable species but retained 'aff. ' records as distinct, as this is most often applied to specimens similar to but distinct from another taxon  (Bengtson, 1988). Preliminary analyses comparing β sim values generated using our treatment of open nomenclature and the 'full' dataset (i. e. , retaining all indeterminate and 'cf. ' records) were highly correlated (r = 0. 97), suggesting that variation in taxonomic treatment has little impact on recovered turnover patterns. Paleoecological Analysis-For paleoecological analysis, two categorical traits (body size and diet) were assigned to each herbivore species from the lower Awash sequence.
Body size was recorded as a six-attribute system, s1 (<25 kg), s2 (25-75 kg), s3 (75-150 kg), s4 (150-350 kg), s5 (350-750 kg), s6 (>750 kg), primarily based on estimates from dentition or postcrania (e. g. , comparison of element sizes with extant species). Diet was based on a three-attribute system, C 4 grazer, C 3 -C 4 mixed-feeder, and C 3 browser. Diet was assigned to species based on enamel stable carbon isotope data  (Robinson et al. , 2017; Wynn et al. , 2016)  and, in very few cases, on tribal or generic affiliation. We visualized paleoecological change through the lower Awash sequence by plotting diet and body size proportions through time. In addition, we compiled and plotted NISP (number of identified specimens) data for large-bodied bovid tribes (Aepycerotini, Alcelaphini, Antilopini, Bovini, Hippotragini, Reduncini, and Tragelaphini) from the Hadar Research Project and Ledi-Geraru Research Project databases.
ACKNOWLEDGEMENTS We thank the  Authority for Research and Conservation of Cultural Heritage (ARCCH) ,  Ethiopian Ministry of Culture and Tourism , and the  Afar Regional State  for permission to conduct field work at  Hadar. Thanks  to the  ARCCH  staff at the  National Museum of Ethiopia  for curation of the  Hadar Research Project collections and for facilitating our study of the Maka 'amitalu fauna. We thank  D. Geraads  and one anonymous reviewer for their valuable suggestions, as well as editor  M. Sponheimer.
Population This study took place in Guadeloupe (FWI), a Caribbean archipelago where most of the inhabitants are of African descent. The Timoun Mother Child Cohort Study included 1,068 pregnant women between November 2004 and December 2007 from the general population, recruited during last-trimester visits at public and private health centers (University Hospital of Guadeloupe, General Hospital of Basse-Terre, Polyclinic of Guadeloupe, and antenatal care dispensaries)  [32]. At inclusion, women were interviewed by trained midwives to assess their medical history, socioeconomic conditions, and dietary habits. At delivery, data concerning maternal diseases during pregnancy, the delivery, and newborn health status and anthropometric characteristics at birth were collected by the medical staff and maternal and cord blood samples were obtained.