dataesr/scientific-paragraphs-categorization huggingface dataset:
Acknowledgements We thank  CYBIO ,  GENOM 'IC and HistIM facilities platform of the  Cochin Institute. We thank  Marcio Do Cruzeiro ,  Nadia Boussetta ,  Matthieu Benard  from the mouse facility platform of  Cochin Institute as well as Claire Lacoste ,  Nicoleta Mitrea ,  Georgeta Fagie  and  Soizic Jezequel  from  UMS  028 mouse facility platform of  Charles Foix Hospital. We thank  Julia Adelöf ,  Ivo Notario ,  Jennifer Da Silva , and  Sandrine Olivre  for technical help. We thank  Yannick Allanore  for providing Infliximab. We thank  Alexandra Corbett ,  Jamie Rossjohn  and  James McCluskey  for providing mouse MR1 tetramers. We thank  Michel Samson  for providing Il23a PCR primers. We thank  Amine Toubal ,  Valérie Gaboriau-Routhiau  and  Nadine Cerf-Bensussan  for critical reading of the manuscript.
As explained in Section 2. 1, each cable is modeled by a resistor R cable , but it would be possible to add an equivalent inductance in series as done in  [24]  in order to be able to model the cable inductive effect on the current dynamic sharing between the fuel cell and the battery. An equivalent cabling capacitor C cable is added for numerical resolution with MATLAB/Simulink. The equivalent circuit dynamic model presented in Figure  4  allows simulating the dynamic behavior of the hybridized system. For each component, the faradic current i f is calculated, which leads the main reaction (redox) in the electrochemical component. This model also allows observing the filtering effect of the electrochemical double-layer phenomena, which is represented here by equivalent capacitors for the fuel cell C dc f c and for the battery C dc bat.
The battery SoC is calculated by integrating the faradic current of the battery i f bat over time. A rapid variation of the fuel cell faradic current i f f c can damage the fuel cell due to starvation phenomena especially happening when the air compressor is not responsive enough and does not provide the necessary amount of oxygen. For the fuel cell, the dynamic of the diffusion phenomena is represented by an equivalent capacitor C di f f f c , which is placed in parallel with a variable current source representing the diffusion overvoltage η di f f. For the battery, the dynamic of the diffusion phenomena is represented by an equivalent capacitor C di f f bat placed in parallel with E stored and a variable resistor R di f f. The parameters identification of the fuel cell dynamic model was carried out from experimental test data on a HT-PEM single cell from Advent with a surface of 45 cm 2.
System Sizing 4. 1. Sizing Methodology The fuel cell sizing (number of cells placed in series Nb f c series ) and the battery sizing (number of accumulators in series Nb bat series , number of branches in parallel Nb bat parallel , and initial state of charge SoC init ) are carried out by a genetic algorithm. The sizing is made with MATLAB and uses the "genetic algorithm" function  [37]. The population size is set at 200 and the number of generations is set at 10. The algorithm is started 400 times to obtain various solutions. In order to simplify the sizing process and analysis, the capacity of one accumulator is set at a value of 5 Ah, and the cell resistance is modified proportionately to the cell capacity, as mentioned in Equation  (7). Thus, the total battery capacity is a discrete multiple of this value.
NiV RNA was detected by nested RT-PCR using speci c NiV primers previously described  [29]. PCR positive specimens were further characterized for NiV sequence to identify viral strain using heminested RT-PCR. Heminested ampli cation was performed from the rst-round PCR product and the nucleotide sequences of N-gene at positions 1197-1553 (according to GenBank Accession No. NC_002728) were analyzed as described previously  [29].
Next generation sequencing (NGS) for Whole Genome Sequencing (WGS) Library Preparation: The extracted nucleic acid previously positive by nested RT-PCR was treated with DNase I and used for DNA library preparation using TruSeq stranded total RNA library preparation kit. The prepared library was run with the MiSeq reagent kit V. 3 (Illumina, USA) on the Illumina MiSeq machine. Two methods were used for WGS assembly: Reference mapping analysis pipeline: The obtained nucleotide sequences were analyzed and mapped to the reference sequence followed by top-hit Blast result downloaded from GenBank. The WGS was assembled using Burrows-Wheeler Aligner (BWA) software  [30] , the consensus sequence was generated using SAMtools  [31]  and the WGS was visualized by Tablet, an NGS assembly visualizer  [32].
The NiV positive bats' pooled urine sample (P. lylei) collected in May 2017 was further characterized for WGS using NGS technology. Sequence was analyzed using two protocols: reference mapping protocol with NiV from Bangladesh 2004 patient as a reference; NGMAP de novo assembly step from IDBA_UD from EDGE Tools. Total of 18,326 nucleotides of WGS were obtained from both protocols which were identical to each other. The phylogenetic tree was constructed, which showed the WGS from NiV isolates from Thailand formed monophyletic group with those from humans and bats (P. medius) in Bangladesh. The genome data was deposited to NCBI GenBank (Accession No. MW535746). Phylogenetic tree of the NiV WGS (Fig. 3 ) showed that the virus was very closely related to NiV from Bangladeshi patient in 2004 (AY988601.
13% nucleotide identity to NiV from a Bangladeshi patient in 2004 (Genbank Accession no. AY988601. 1). On the contrary, previous WGS of NiV from Cambodian (MK801755. 1) bats were NiV-MY strain. Overall homology of naturally circulating NiV strains in Thailand with previously detected human infectious strains from Bangladesh highlights the outbreak potential of NiV from P. lylei to humans or pigs in the Southeast Asian region. Routine NiV serosurveillance in pigs in Thailand has been conducted annually since 2001 by DLD. At least 4,000-5,000 pig sera are collected annually around the country for NiV antibody testing by ELISA at high-risk sites selected by DLD on the basis of bat NiV studies  [2]. To date, no NiV-seropositive pig has been identi ed from this DLD initiative  [27]. [40]. In the Indonesian study, all 610 pig sera tested negative despite 19% of seropositive P.
were 99. 81%, 99. 44%, 100. 00%, 98. 90%, 99. 83% and, 99. 55%, respectively (Table3). Furthermore, the virus shared 97. 82% (17813/18210 nucleotides, 397 nt difference) with NiV isolated from an Indian patient from the recent outbreak in 2018 (GenBank Accession No. MH396625).
Funding This was supported by research grants from the  King Chulalongkorn Memorial Hospital 's  Excellent Center Program  ( EC-63-30101-29 ), the  Biological Threat Reduction Program (BTRP)  of the  US Defense Threat Reduction Agency (DTRA)  ( HDTRA1-08-D-0007 ), the  Thailand Research Fund  ( RDG5420089 ), and the  Food and Agriculture Organization (FAO)  of the  United Nations. Generous support for this work was provided by the American people through the  United States Agency for International Development (USAID) 's  Emerging Pandemic Threats PREDICT project  (Cooperative Agreement No. AID-OAA-A-14-00102 ). Additionally, research reported in this publication was supported by the  National Institute of Allergy and Infectious Diseases (NIAID)  of the  National Institutes of Health (NIH)  under the award number  U01AI151797  and  NIH/NIAID/CREID/07-049-7012-52338.
were 99. 81%, 99. 44%, 100. 00%, 98. 90%, 99. 83% and, 99. 55%, respectively (Table3). Furthermore, the virus shared 97. 82% (17813/18210 nucleotides, 397 nt difference) with NiV isolated from an Indian patient from the recent outbreak in 2018 (GenBank Accession No. MH396625). Table 3 Identity shared between THAB17640. GUL with NiV from Bangladesh patient in 2004 (GenBank Accession No. AY988601. 1) Target gene Amino acid Nucleotide % Identity of % Identity of sequence range sequence range Amino acid Nucleotide Nucleocapsid 1-532 56-2297 99. 81 (531/532) 99. 29 (N) (2226/2242) Phosphoprotein 1-709 2301-5004 99. 44 (705/709) 99. 59 (P) (2693/2704) Matrix protein 1-352 5108-6366 100. 00 98. 81 (M) (352/352) (1244/1259) Fusion protein 1-546 6370-8712 98. 90 (540/546) 98. 85 (F) (2316/2343) Glycoprotein 1-602 8716-11261 99.
3. To analyze the samples, the ZnSe crystal was removed from the drying chamber and then a second ZnSe crystal was used to sandwich the cells. To avoid any release of cells, the periphery of the sandwich was wrapped with a parafilm Table Such a sandwich was necessary because the FTIR spectrometer was not in a biosafety level 2 laboratory. Samples were placed in the FTIR spectrometer (Vector 22; Bruker, Karlsruhe, Germany), which was equipped with a mercury-cadmium-telluride (MCT) detector. The spectral resolution was 4 cm -1. To obtain the spectra for each sample, 50 scans were recorded from 900 cm -1 to 4000 cm -1 and analyzed using OPUS 6. 5 software (Bruker). Several data preprocessing algorithms were used to analyze all FTIR spectra. Data preprocessing first included a smoothing of the spectrum (17 smoothing points, provided by OPUS 6.
Observation of L. monocytogenes by AFM Images of cells dried or instantaneously rehydrated onto coverslips coated with poly-D-lysine were collected in the air or in liquid PBS for control (cells incubated to 99% RH) using a Multimode NanoScope 8 microscope (Bruker, Veeco Instruments, Santa Barbara, CA, USA). A ScanAsyst-HR-AIR cantilever (Bruker) of spring constant k = 0. 4 N/m was used for measurement in peak force mode and the scan rate was 1 Hz. Representative AFM images of cells before and after desiccation and rehydration were derived from at least three experiments. Images were analyzed with NanoScope Analysis 1. 5 software (Bruker).
Statistical Analysis All data were collected in four independent experiments. To compare the various results obtained herein, the variance homogeneity (F-test) was assessed. Our results revealed a homogeneous variance (p > 0. 05). ANOVA and Tukey's honestly significant difference test (with p < 0. 05 indicating statistical significance) were performed to determine whether significant differences existed between different stress conditions. Analyses were performed using R software (version 3. 1. 2).
The reliability of the published data is generally estimated according to their representation in the French market, recentness and analytic method. Several hypotheses might explain this protective effect. In the presence of NaCl, cells dry less quickly, remain in an aqueous solution longer and have less contact with the oxygen in the air compared with cells dried at low NaCl concentrations. High NaCl concen-  C and 75% RH for 3 h and rehydrated in various liquid matrices. The bacteria were suspended and then dried in different solutions: 3% NaCl (0. 989 a w ), 0. 9% NaCl (0. 997 a w ), 0. 1% NaCl (0. 999 a w ), 0. 01% NaCl (0. 999 a w ), distilled water (1. 000 a w ), city water (1. 000 a w ) and PBS (1. 000 a w ). Subsequently, rapid rehydration was performed in ( ) PBS, ( ) distilled water or ( ) the same liquid matrix used for dehydration.
Funding: This work was supported by the  Agence Nationale de la Recherche  ( ANR-12-ALID-0005 ) ( ANR)  under the project " EcoSec ". Work carried out at  UMR PAM (Dijon, France)  was part of the project  ALIM+ ,  2016  supported by the  Conseil Régional de Bourgogne-Franche Comté  and the  European Union  through the  PO FEDER-FSE  Bourgogne  2014/2020  programs. Institutional Review Board Statement: Not applicable. Informed Consent Statement: Not applicable.
Band structure calculations were performed with the density functional theory (DFT)  [56]  as implemented in the Vienna ab initio simulation package  [57, 58]  with the projector augmented-wave method,  [59, 60]  based on Heyd-Scuseria-Ernzerhof (HSE) hybrid  [61] [62] [63]  and metaGGA (TB-mBJ)  [45]  functionals with an energy cutoff of 500 eV. Besides, topology related (including band structures and Berry phase) calculations were carried out by generating ab initio tight-binding Hamiltonians from the maximally localized Wannier functions within HSE potential,  [42]  as implemented in Wannier Tools package. [64] The Bloch wave functions are projected onto the s, p, d atomic orbitals of Ga and s, p atomic orbitals of P, As, and Sb. The standard generalized gradient approximation (GGA) parameterized by Perdew-Burke-Ernzerhof (PBE)  [65]  was used for structure optimization and the structures were relaxed until the Hellmann-Feynman forces on the atoms were less than 10 -4 eV Å -1.
Acknowledgements The authors acknowledge Pr. E. Hassinger  for fruitful discussions on topological insulators and semimetals,  Dr. J. -B. Rodriguez ,  Dr. L. Cerutti , and  Pr. E. Tournié , for sharing their experience on physical properties of GaSb/Si materials and  RENATECH (French Network of Major Technology Centers) within Nanorennes  for technological support. This work was supported by  Rennes Métropole  through the  "REMOTE" project. Lipin Chen  acknowledges the  China Scholarship Council (CSC)  for her Ph. D. financial support (No. 2017-6254 ). DFT calculations were performed at  Institut FOTON  and the work was granted access to the  HPC resources of TGCC/CINES/IDRIS  under the allocation  2020-A0080911434  and  2021-A0100911434  made by  GENCI.
Introduction: Heart failure decompensation can be triggered by many factors, including anemia. In cases of iron deficiency anemia or iron deficiency without anemia, endoscopic studies are recommended to rule out the presence of gastrointestinal neoplasms or other associated bleeding lesions. Objectives: The aims of this study were to (i) examine trends in the incidence, clinical characteristics, and in-hospital outcomes of patients hospitalized with heart failure from 2002 to 2017 who underwent esophagogastroduodenoscopy (EGD) and/or colonoscopy, and to (ii) identify factors associated with in-hospital mortality (IHM) among patients with heart failure who underwent an EGD and/or a colonoscopy. Methods: We conducted an observational retrospective epidemiological study using the Spanish National Hospital Discharge Database (SNHDD) between 2002 and 2017.
Design, Setting and Participants We designed a retrospective observational investigation obtaining data from the Spanish National Hospital Discharge Database (SNHDD)  [12]. The study time-period included all of the years from 2002 to 2017. The SNHDD collects information for each hospital admission, including patient's characteristics (sex and age), diagnosis, and procedures conducted during the hospital stay, as well as in-hospital mortality (IHM). The International Classification of Diseases Ninth Revision (ICD-9CM) was used by the SNHDD for coding from 2002 to 2015 and the Tenth Revision (ICD-10) for years 2016 and 2017. The study population included adults (≥ 18 years) that, according to the criteria of the American College of Cardiology/American Heart Association  [13] , suffered heart failure, using the codes listed in Table  S1.
Data Availability Statement: Can be accessed from the Spanish Ministry of Health databases of the SNHDD, which provides it free of charge, in the following link: https://www. mscbs. gob. es/ estadEstudios/estadisticas/estadisticas/estMinisterio/SolicitudCMBDdocs/2018_Formulario_Peticion_ Datos_RAE_CMBD. pdf (accessed on 12 November 2020).
Trial design and participants This multicentre, single-arm, phase II 'BELIEVE' study was registered at ClinicalTrials. gov (NCT02704429). All patients provided written informed consent, the study was approved by local regulatory bodies and institutional review boards or ethics committees, and it was conducted in accordance with the Declaration of Helsinki and International Conference on Harmonisation guidelines for good clinical practice. The study protocol is provided in Appendix S1 (see Supporting Information). Patients were 18-80 years of age with a clinical diagnosis of new-onset or relapsing, moderate-to-severe PV based on histopathological (intraepithelial blistering with acantholysis) and immunohistological (positive direct immunofluorescence) evaluations. Newly diagnosed patients were ≤ 6 months, and relapsing patients were > 6 months to 10 years from disease onset or diagnosis at screening.
Statistical analysis All patients receiving at least one dose of rilzabrutinib were included in the safety and efficacy populations (Figure  S2 ; see Supporting Information). Patients completing 12 weeks on rilzabrutinib and 12 weeks post-treatment (i. e. 24 weeks) were an exploratory 'completer population'. Quantitative results were summarized using descriptive statistics. Efficacy and time-to-event results, including twosided 95% confidence intervals (CIs), were evaluated by the exact Clopper-Pearson method and Kaplan-Meier estimates. All statistics were calculated with SAS version 9. 2 or later (SAS Institute Inc. , Cary, NC, USA).
29 n conclusion, this study confirms rilzabrutinib as the first BTK inhibitor showing a favourable risk-to-benefit profile in PV. Rilzabrutinib was effectively and safely combined with zero low-dose CS for a rapid response. Following this proof-of-concept trial, a phase III pivotal study (PEGASUS; NCT03762265) of rilzabrutinib vs. placebo with CS taper is underway for PV.
Acknowledgments We thank the patients who participated in the trial, their caregivers, the trial investigators (Table  S1 ), members of the BELIEVE-PV data and safety monitoring board and adjudication committee, and members of the BELIEVE-PV trial team. Thank you to  Professor Branka Marinovic  for providing clinical expertise that supported the conception of the study and for screening patients, although none were enrolled at her institution. We also thank  Fiona Liu  for statistical support, and  Julie Kern, PhD ,  CMPP  and  Kristin MacIntosh Teasell, MS, CMPP  of  Second City Science LLC  for their medical writing and editorial assistance (funded by  Principia Biopharma Inc. , a  Sanofi Company). This study was supported by  Principia Biopharma Inc. , a  Sanofi Company. Statistical analyses of the data were provided by  Principia Biopharma Inc.
Study design We conducted this prospective single-arm trial in 15 European hospitals. Adults scheduled for elective VHWG grade 3 incisional hernia repair were included. VHWG grade 3 comprises hernias in a surgical site in which there has been previous wound infection, on which a stoma is present, or in which violation of the gastro-intestinal tract takes place. Additional inclusion criteria with regard to the hernia were a midline position and a size of more than 10 cm 2. An elaborate overview of the exclusion criteria has been previously published  [15, 17]. The research protocol was approved by the institutional review board or health authority of every participating center, has been previously published  [17] , and is registered at clinicaltrials. gov (NCT02720042). All included patients gave written informed consent prior to any study procedure.
Sample size and statistical analysis Seventy-five patients were deemed sufficient to evaluate the performance of Phasix™ Mesh. Anticipating an attrition rate of 10%, the aim was to include 85 patients. Data from all included patients implanted with Phasix™ Mesh were analyzed. Baseline characteristics were summarized with frequency counts and percentages, or with mean and standard deviation (sd). Follow-up is summarized through median with range. Short-term and long-term endpoints are reported as proportions or means with a 95% confidence interval (95% CI) or as medians with range or interquartile range (IQR). The long-term endpoint of recurrence was assessed through time-to-event analysis. No missing value imputation methods were used. Analysis was through an intention-to-treat principle, with Statistical Analysis System (SAS), Version 9.
Acknowledgements We would like to thank all who contributed materially to our study as participating investigators:  S. Gruber-Blum ,  C. May ,  A. Hofmann ,  N. Van De Winkel ,  A. Vanlander ,  A. Reinisch ,  H. Elyouzouri ,  M. K. Hensler ,  R. B. Arnesen ,  T. Crombe ,  M. Gualtierotti ,  A. Gandon ,  M. Messager ,  C. Dubois ,  V. Tan ,  M. Leconte ,  M. Weinandt ,  P. Negro ,  E. Annesi ,  L. D'Amore ,  A. G. Menon ,  K. H. A. van Eeghem ,  J. Wegdam ,  L. F. Kroese ,  A. P. Jairam , and  S. Parker.
Methods This is a retrospective multicenter analysis using the data set from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) registry. The study protocol was approved by the scientific council of the SFGM-TC and complied with French regulatory requirements. The study was conducted according to the Declaration of Helsinki. All patients provided written informed consent authorizing the use of their personal information for research purposes. We collected data from all patients up to the age of 40 years old included in the SFGM-TC registry from January 2005 to December 2017 who received a first allogeneic HSCT for treatment of AML. Inclusion criteria were: patients younger than 41 years old who accepted to be registered in the SFGM-TC registry, treated with a first allogeneic HSCT for AML in first or further remission and also in refractory state.
Proportional hazard assumption was checked for each time-to-event outcome-predictor combination, and if violated, a time-dependant interaction term was added in the model. Then, univariate analyses were conducted including the interaction term and after censoring the follow-up to the competitive event when required. Independent risk-factors of each time-to-event outcome were explored using multivariable Cox regression model with significance levels for entry (SLE) and for stay (SLS) of 0. 20 and 0. 05, respectively. Statistical analyses were performed using SAS version 9. 4. The level of statistical significance was set at 0. 05.
Transplantation characteristics and comparison of patients in the three age groups We analyzed data from 2645 patients aged from 0 to 40 years old, who received a first allogeneic HSCT between January 2005 and December 2017 from 43 SFGM-TC centers. The patient's characteristics are presented in Table  1. The median follow-up of the study was 2. 4 years (min-max 1 day-14. 7 years), from the time of transplant to death or latest news date. Among alive patients, the median follow-up of the study was 4. 37 years (min-max 0. 18-14. 73 years). Three age groups were assessed: 564 children aged from 0 to 14 years, 647 Adolescent and Post-Adolescent (APA) patients aged from 15 to 25 years, and 1434 young adult patients aged from 26 to 40 years. The cytogenetics risk, the extramedullary involvement at diagnosis and the disease status at transplant were different in the three groups (p < 0.
Architecture of the genomic region spanning Vat genes in cucurbits We obtained 300-350 kb containing several Vat homologs in seven melon lines: PI 161375 (a Korean line), Anso77 (a Spanish line), Doublon (a French line), Payzawat and HS (both Chinese lines), DHL92 (a doubled haploid line derived from a cross between PI 161375 and the Spanish line Piel de Sapo), and Harukei-3 (a Japanese line). We first obtained a 610 kb contig for PI 161375 by assembling seven BACs sequenced using PacBio technology (Methods S1 and Fig. S1 ), one of which had previously been identified as spanning two Vat homologs  4. From this sequence, we defined a 301. 5 kb genomic region between M5 and M4 genetic makers containing all of the Vat homologs we identified within the 610 kb region. We used a blast/mapping strategy to retrieve sequences from M5 to M4 in assemblies of six other melon lines (Data S1).