dataesr/scientific-paragraphs-categorization huggingface dataset:
In the Allergome database, 20 b-amylase from barley is also listed as allergen Hor v 17, but according to the allergenicity scoring it is only found positive in non-functional testing like immunoglobulin (Ig)E/IgE immunoblot testing. Moreover, it is indicated that no data on oral-, bronchial-, nasal-and conjunctival-provocation testing and skin testing, as well as on functional testing, such as the basophil degranulation/activation test, are available. b-Amylase from barley is described as an occupational respiratory allergen that can induce occupational asthma in bakers and millers (Sandiford et al. , 1994). In the various allergen databases, several other barley proteins (e. g. Hor v 12, Hor v 15, Hor v 16 and Hor v 20) are also listed as being associated with mainly baker's asthma (Barber et al.
Gluten proteins extracted from barley grain In Regulation (EU) No 1169/2011 21 , barley is listed as gluten-containing cereal which therefore can elicit coeliac disease, a form of gluten intolerance. However, because gluten is poorly soluble in water,  17  Available from: www. allergenonline. org 18 Available from: www. allergen. org 19 Allergen nomenclature database: Hor v 17: Hor(deum) v(ulgare), the species name of barley and allocated index number. 20  the food enzyme obtained via extraction of barley grain using an aqueous solution is expected not to contain gluten. The applicant provided analytical data on three batches of the food enzyme, demonstrating that the gluten content was below the limit of quantification ( food enzyme) of the applied ELISA-based method. Based on the estimated dietary exposure to the food enzyme TOS in six population groups (Table  3 ), the highest potential exposure to gluten from the food enzyme was calculated (for adults) and amounts to per day, which is several orders of magnitude lower than the exposure from the gluten-free foods with the threshold value of 20 mg/kg set for the labelling of foods as 'glutenfree' specified in European Commission Regulation (EC) 41/2009 22.
Discussion The food enzyme is obtained from barley grain, i. e. an edible plant source. The Panel considered the information provided on the source material, the manufacturing process and the composition of the food enzyme sufficient to conclude on its safety. The food enzyme is intended to be used in several food-manufacturing processes: baking and brewing processes, distilled alcohol production, and starch processing for the production of glucose syrups. The use levels recommended for these food processes have been provided. Exposure to the food enzyme-TOS was estimated using individual data from the EFSA Comprehensive Database. This exposure was similar to or lower than the exposure to a fraction of barley comparable to the food enzyme-TOS, resulting from the consumption of barley-derived foods.
Data collection Clinical data. BMI at surgery and 6 months before the onset of pregnancy, and timing between surgery and pregnancy were recorded for the women who had had bariatric surgery. Maternal age at birth, BMI at the onset of pregnancy, total weight gain during pregnancy, tobacco consumption, parity, mode of delivery, duration of labor, and placenta weight were recorded. Newborn birth weight, length and head circumference, Apgar score, gestational age (using ultrasonographic criteria from early ultrasound scan), and breastfeeding status were recorded. The percentile for birth weight was calculated, according to the standard French Association des Utilisateurs de Dossiers Informatisés en Pédiatrie, Obstétrique et Gynécologie growth curves  [19]. Large-for-gestational-age infants were defined as those with a birth weight 490 th percentile for sex and gestational age, and small-for-gestational-age infants as those with a birth weight o10th percentile.
No clinical data were missing. For each biological variable, 0 to 6 values were missing per group, mainly for technical reasons (insufficient quantities of blood; hemolysis). Multiple imputation with data augmentation was also performed to impute missing data. Thirty imputations using a sequential chain of iterations were performed. The assumption of this multiple imputation process is that data are missing at random. Group comparisons were performed on imputed data as well as on the original data set, and differences were considered significant only when found so both on the original data set and the imputed data. Significance was defined as P o. 05. All analyses were performed with the IBM SPSS Statistics 19. 0 (Armonk, NY, USA) package. We followed STROBE (Strengthening The Reporting of OBservational studies in Epidemiology) guidelines.
Acknowledgments We thank  Dr. Dorothee Frein ,  Dr. Philippe Topart ,  Dr. Françoise Schmitt ,  Dr. Claire Briet , and  Dr. Natacha Bouhours-Nouet  for taking care of the patients and for helpful discussion regarding the present study as well as the drafting of the manuscript. We thank  Catherine Carmeni , medical writer, for her help. The record of medical information as well as the maternal and cord blood analyses were supported by the French national health security system, as part of the usual care.
Study design We collected data from patients with an established AIH diagnosis from 19 centers across Europe, USA, Canada and China. AIH was diagnosed based on a combination of autoimmune serology, serum gamma globulin or immune globulin G (IgG) levels and compatible liver biopsy findings  [17]. Overlaps of AIH with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) were classified according to suggested international guidelines  [18]. All patients who were treated with second line agents were identified. Patients with insufficient information or non-compliance to therapy, those presenting with acute severe AIH as well as patients diagnosed with overlapping PBC or PSC were excluded. A flow chart for patient inclusion is presented in Figure  1.
To reduce predictability of a random sequence, details of any planned restriction statistical methods to handle missing data (eg, multiple imputation) ______9______ ______28______ Methods: Participants, interventions, and outcomes (eg, blocking) should be provided in a separate document that is unavailable to those who enrol participants or assign interventions limit such access for investigators Methods: Monitoring Access to data 29 Statement of who will have access to the final trial dataset, and disclosure of contractual agreements that ______N/A_____ Study setting Eligibility criteria Allocation concealment mechanism Data monitoring Ancillary and post-trial care Interventions Implementation Dissemination policy 31a 9 10 16b 21a 30 11a 11b 16c Blinding (masking) 17a 21b Harms 22 31b 17b 31c Description of study settings (eg, community clinic, academic hospital) and list of countries where data will be collected.
Alternatively, an explanation of why a DMC is not Interventions for each group with sufficient detail to allow replication, including how and when they will be administered Criteria for discontinuing or modifying allocated interventions for a given trial participant (eg, drug dose change in response to harms, participant request, or improving/worsening disease) Who will generate the allocation sequence, who will enrol participants, and who will assign participants to interventions needed Plans for investigators and sponsor to communicate trial results to participants, healthcare professionals, Who will be blinded after assignment to interventions (eg, trial participants, care providers, outcome assessors, data analysts), and how Description of any interim analyses and stopping guidelines, including who will have access to these interim the public, and other relevant groups (eg, via publication, reporting in results databases, or other data sharing arrangements), including any publication restrictions results and make the final decision to terminate the trial Plans for collecting, assessing, reporting, and managing solicited and spontaneously reported adverse Authorship eligibility guidelines and any intended use of professional writers If blinded, circumstances under which unblinding is permissible, and procedure for revealing a participant's events and other unintended effects of trial interventions or trial conduct Plans, if any, for granting public access to the full protocol, participant-level dataset, and statistical code ______11______ ______25_____ ______N/A_____ ______N/A_____ ______11-12___ _____12-16____ ______29______ ______24______ ______N/A____ ______24______ ______N/A_____ ______29______ _____N/A_____ ______N/A_____ ______N/A_____ 11c 23 11d 12 32 Methods: Data collection, management, and analysis Strategies to improve adherence to intervention protocols, and any procedures for monitoring adherence allocated intervention during the trial Auditing Frequency and procedures for auditing trial conduct, if any, and whether the process will be independent Appendices from investigators and the sponsor (eg, drug tablet return, laboratory tests) Relevant concomitant care and interventions that are permitted or prohibited during the trial Outcomes Primary, secondary, and other outcomes, including the specific measurement variable (eg, systolic blood pressure), analysis metric (eg, change from baseline, final value, time to event), method of aggregation (eg, Informed consent Model consent form and other related documentation given to participants and authorised surrogates Data collection methods 18a Plans for assessment and collection of outcome, baseline, and other trial data, including any related study instruments (eg, questionnaires, laboratory tests) along with their reliability and validity, if known.
(12) Throughout this paper we have used the artificial broadening 0 + = 0. 01t. To compute the LDOS at the STM tip position, we change the basis and obtain the continuum Green's function using  31. G σ (r, ω) = ij G ijσ (ω)W i (r)W * j (r), (13) where W i (r) is the Wannier function at site i, and r is a three dimensional continuum real space vector. The Wannier function employed in this paper was generated using the Wannier90 package  33  , and is similar in form to that used in Ref. 32. Note that the local Green's function contains nonlocal contributions from all lattice sites. The continuum local density of states is now easily obtained as ρ σ (r, ω) = - 1 π Im[G σ (r, ω)] (14) In most of the previous theoretical works  16, 17, 19  , intraunit cell form factors were calculated using the Fourier transform of the nearest neighbor bond order χ i,i+x(ŷ) , which can be regarded as the measure of charge density at the oxygen atoms on x(y) bonds at lattice site i.
Acknowledgements. The authors are grateful for useful discussions with B. M. Andersen ,  J. C. Davis ,  K. Fujita ,  S. Hayden ,  A. Kreisel ,  S. Maiti ,  C. Pépin ,  T. M. Rice ,  S. Sachdev ,  A. -M. S. Tremblay  and  S. Verret. PC and PJH were supported by  NSF  grant  NSF-DMR-1407502. PJH's work was performed in part at the  Aspen Center for Physics , which is supported by  National Science Foundation  grant  PHY-1066293. WLT and TKL were supported by  Taiwan Ministry of Science and Technology  Grant  104-2112-M-001-005. Part of calculation was supported by the  National Center for High Performance Computing in Taiwan.
Every sample was tested using parallel detection 3 times to obtain the average Ct value. Differences in total RNA per reaction were normalized using GNB2L1 (guanine nucleotide binding protein beta polypeptide 2-like) as an endogenous control and a calibrator (the sample loaded in the first three wells of the plate). Primer pairs and probes for DRD4 and GNB2L1 (guanine nucleotide binding protein beta polypeptide 2-like) were designed using Primer Express software, and the sequences of the primers and probes for 5HTR2A were obtained from the literature  [26]. All primers and TaqMan probes were synthesized by Syntol JSC (Moscow, Russia). The sequences are shown in Table  2. Real-time PCR was carried out with 1 μL of cDNA templates using 1. 5 μL of pairs of primers, 2 μL of TaqMan probes (100 nM, target gene and GNB2L1), 10× Reaction Buffer, MgCl2, 10 mM dNTP Mix and Taq polymerase for a final reaction volume of 50 μL.
Statistical analysis The statistical analysis was performed using statistical software SPSS version 21 (IBM, USA). Continuous variables were assessed for normal distribution, and a oneway ANOVA was then used to evaluate the significance of the differences. For dichotomous variables, the Chisquare test was used. Because the data for mRNA levels and dopamine serum levels were not normally distributed, non-parametric tests were used. The Mann-Whitney (U) test was performed to compare DRD4 and 5HTR2A mRNA levels and dopamine serum levels between treatment groups (haloperidol vs. olanzapine). The comparison between repeated measures at the longitudinal trajectory of these indicators within one treatment group was performed using Friedman's test. PANSS, CGI, SAS and EPRS scores were not continuous variables; thus, Spearman's correlation analysis was used to analyse the relationship between the mRNA levels of the two target genes, dopamine serum levels and scale scores.
Dynamics of the mental state in patients during the administration of antipsychotics Between June 2014 and April 2016, 60 schizophrenic patients with first-episode psychosis were randomly assigned to olanzapine treatment (n = 30) or haloperidol treatment (n = 30 as a comparison [control] group). These antipsychotic drugs were chosen due to their preferred use in treating first psychotic episodes, with haloperidol as the first choice and olanzapine the second choice  [27]. The patients included in the study were screened to identify novel peripheral markers (based on biogenic amines) of the efficiency of olanzapine treatment for schizophrenia. The demographic and clinical data of the two groups of schizophrenic patients under antipsychotic therapy are summarized in Table  1. Both treatments were well-tolerated.
olanzapine)). The reduction in the total score according to the PANSS was likely due to a reduction in the indices of positive symptoms and general psychopathological features for olanzapine and a reduction in the indices of positive symptoms for haloperidol. The data are shown in Fig. 1. Moreover, the mean values for the CGI-S and CGI-I scales decreased in both groups but were not significantly different between the two groups (p = 0. 786). Extrapyramidal side effects were more frequent in the haloperidol group than in the olanzapine group according to the SAS and ESRS. Twenty-seven (90%) patients on haloperidol had at least one extrapyramidal adverse event, compared with 18 (60%) patients on olanzapine (p<0. 05). The spectrum of clinical manifestations in the two groups differed: parkinsonism and mixed extrapyramidal syndrome in the haloperidol group vs.
Young patients that could benefit from auricular treatments are presented. A special emphasis is laid upon the therapeutic strategy used and the observed outcome. Randomized, double-blind, multicentric clinical trials are urgently needed and should take advantage of this 2017 Singapore Symposium. Background: Since the end of 1950s, auricular therapy and clinical application have attracted much attention from a large number of researchers home and abroad, which greatly stimulated the enthusiasm of auricular acupuncture among the whole Chinese acupuncture societies in china. On the basis of sorting out the ancient literature, the Chinese researchers have carried out countless clinical researches and exploration. In order to analyze diagnosis and treatment with auricular points during the last ten years, from 2007 to 2016 in China, China-Tsinghua Tongfang "CKNI" (China National Knowledge Infrastructure) Journal Full-text Database was applied for data retrieval source article about the application of auricular points, and main research program results are summarized in order to provide a theoretical basis for understanding and development of auricular therapy in China and all over the world.
Methods: To analyze the diagnosis and treatment of auricular points during the past ten years (2007 to 2016) in China, China-Tsinghua Tongfang "CKNI (China National Knowledge Infrastructure) Journal Full-text Database" was applied to search the relevant research articles with the "auricular acupuncture" as the key word, which are about the history, the overall situation, standardization and so on. Results: According to data mining on the recent ten years' literatures, high-frequency symptoms treated by auricular acupuncture, high-frequency diseases treated by auricular acupuncture, qualities of different levels of researches, the overall research progress on auricular acupuncture were summarized, and existing issues were found and development prospects are analyzed. Conclusions: Auricular acupuncture for the treatment of various diseases has been widely used in China, and gain very good clinical effects for some specific diseases.
Does Ear Acupuncture Have A Role for Pain Relief in the Emergency Setting? A Systematic Review and Meta-Analysis Jan, A. ; Aldridge, E. ; Rogers, I. ; Visser, E. ; Bulsara, M. ; Niemtzow, R. Objective: Ear acupuncture might be the form of acupuncture best suited to improving emergency pain management. Our primary aim was to assess the efficacy of acupuncture in the emergency setting while secondary objectives were to explore its suitability through patient satisfaction, adverse effects, cost, administration techniques and medication usage reduction. Methods: Seven data bases and Google Scholar were searched up to 27th April 2017 using MeSH descriptors for three overarching themes concerning ear acupuncture, pain management and emergency medicine. Meta-analysis was performed in three comparator groups of: acupuncture versus sham, acupuncture-as-adjunct to standard care and acupuncture (both sole and adjuvant) versus control to calculate the standardised mean difference and weighted mean difference for pain scores out-of-ten.
Results: Six randomised controlled trials and two uncontrolled observational studies totalling 458 patients were retrieved after exclusions. The meta-analysis used data from four randomised studies representing 286 patients. The above three comparator groups resulted in standardised mean differences of 1. 69, 1. 68 and 1. 66, and weighted mean differences of 2. 47, 2. 84 and 2. 61 respectively with all figures favouring acupuncture. Where measured, there were no adverse effects and patient satisfaction was improved. Results regarding reduction in medication use were equivocal. Significant study bias was found and Battlefield acupuncture was the most commonly used technique. Conclusions: While study numbers are limited, ear acupuncture appears efficacious, either as stand-alone or as adjunct analgesia.
The Use of Auriculotherapy for Cardiac Arrhythmias: A Systematic Review Mok, M. ; Suen, L. ; Tan, J. Y. ; Xie, G. Background: Patients with paroxysmal type of cardiac arrhythmia often experience poor quality of life due to the low successful rate of the mainstream treatments in controlling the disorder. Being one of the complementary health approaches, auriculotherapy was found to be a safe treatment modality which may benefit patients with cardiac arrhythmias. This systematic review therefore evaluates the effectiveness of auriculotherapy on patients with this problem. Method: Literatures were searched through Pubmed, Embase, CENTRAL, China National Knowledge Infrastructure (CNKI), WangFang Database, and VIP Database using relevant keywords and mesh terms. All articles were screened by title and abstract to identify relevant clinical studies.
The local energy doses was given at 4. 0 J/body acupuncture point and 0. 5 J/ear acupuncture point. In addition to CM treatment the use of laser areatherapy LowLevelLaserLight (LLLT) with cluster probe (RJ-Physiolaser Olympic; Cluster Probe 516C superpulsed (directed beam) 5 × 904 nm/30 Watt) positioned under sternum directed towards heart (mimic 4-chamber view) will be demonstrated. Abstract: To explore domestic auricular point therapy for insomnia in recent 10 years. The keywords retrieving clinical research papers include auricular point, insomnia, auricular point pressing therapy, auricular acupuncture therapy, auricular bloodletting method, needle-embedding method, auricular therapeutic apparatus. The databases are CNKI, WANGFANG, and VIP. Eighty-nine target theses were collected and analyzed.
Clinical Application of Auricular Point Treatment for Upper Respiratory Tract Infection in Children Yang, L. Background: This paper investigated application status of upper respiratory tract infection in children treated by auricular point, in order to provide references for clinical application. Methods: The literature on auricular point treatment for upper respiratory tract infection in children was collected from CNKI and Wanfang from the start of building database to 2017. Main search terms were "auricular point", "auricular acupuncture", "auricular piont sticking", "ear", "exopathy", "fever", "high fever", "common cold", "upper respiratory tract infection", "children", and etc. The literature was analyzed on characteristics of point selection and treatment method of auricular point treatment for upper respiratory tract infection.
g. prey size), it is possible to estimate how much of the total population variance is explained by differences within vs. between individuals. In practice, the average intra-individual variance ('withinindividual component' of the niche, WIC) is calculated, and divided by the sum of the inter-individual variance ('between-individual component', BIC) and the intra-individual variance (WIC + BIC = TNW, the 'total niche width'). This index (WIC/TNW) varies from 0 (complete individual specialisation) to 1 (no individual specialisation). Empirical values can be compared with a null model (randomisation of prey items between individuals). This approach can be implemented in the R package RInSp  (Zaccarelli et al. 2013). The method can also be extended to discrete data such as the frequency of alternate prey in the diet by using diversity indices as a proxy for variance  (Bolnick et al.
ANOVA 2 2 2 R = σ σ + σ α α ε tables use the ratio of the sums of squares to estimate repeatabilities  (Lessells & Boag 1987). The statistical significance of the repeatability can be tested with a randomisation test: measurements (e. g. isotope ratios) are reshuffled many times between individuals and repeatability is calculated for each randomisation. The corresponding p-value is the proportion of random isations that produce a repeatability index greater or equal to the observed repeatability. This can be implemented in the R package rptR  (Nakagawa & Schielzeth 2010). In theory, when data are normally distributed and the design of the study is balanced (equal number of measurements for each individual), an even simpler approach is to test for a correlation (Spearman's or Pearson's correlation) between pairs of measurements taken at different points in time for each individual (correlation-based repeatability; Nakagawa & Schielzeth 2010).
Analyses of trip summary statistics Spatial information collected by tracking devices will typically be in 2 dimensions (latitude and longitude). Therefore, in order to apply the methods listed above (correlations and repeatability analysis), spatial data are typically reduced via summary statistics to a single dimension, or are analysed separately (e. g. Phillips et al. 2005 , Dias et al. 2013 , Ceia et al. 2014 , Yamamoto et al. 2014 , Potier et al. 2015). The most common summary data derived from each trip that have been used in this way include the total duration, total distance travelled (summed great circle distances between fixes), maximum range (great circle distance to the furthest location), and bearing at departure or to the furthest point  (Hamer et al. 2001 , 2007 , Soanes et al.