dataesr/scientific-paragraphs-categorization huggingface dataset:
Then, cross-validation was undertaken with dried blood spots and plasma samples collected from individuals with confirmed infections to SARS-CoV-2 and a control group. All assays (SPR, in-house ELISA and a commercial ELISA kit), all sample types (dried blood spots and plasma) and proteins (spike and nucleocapsid) led to excellent discrimination of the positive and negative values ( p < 0. 01) and cross-correlation with Pearson's coefficients above 0. 85, demonstrating the excellent performance of the various antibody screening methods. As antibody detection is needed for epidemiological surveys, to assist vaccine development and to provide data in the deployment of large-scale vaccination campaigns and follow-up studies, we demonstrate here that SPR sensing can be a significant tool in the several studies that will be undertaken.
Acknowledgements The authors thank  Maxine Joly-Chevrier  and  Ève-Marline Joseph-Valcin  and acknowledge financial support from the  Canadian Institutes of Health Research (CIHR) , the  Natural Sciences and Engineering Research Council of Canada (NSERC)  from the  Discovery grant program  and the  College and Community Innovation Program -Applied Research Rapid Response  to  COVID-19  and the  Canadian Foundation for Innovation (CFI).
Acknowledgments: Authors acknowledge the financial support of  China Scholarship Council  for Zhang Zhao thesis fellowship. We also acknowledge the supports of the  European Union (FEDER) , the  Région Haut de France , the  Ecole Supérieur de Chimie Organique et Minérale (ESCOM) , and  Université de Technologie de Compiègne (UTC)  through funding of the chair: " Green Chemistry and Processes ".
CT scans were then categorised into three different radiological patterns: no residual anomalies; residual ground glass and parenchymal bands defining a pattern of late OP; and lastly, fibrotic lung changes if traction bronchiectasis, reticulations or honeycombing were observed, regardless of other anomalies. Additionally, demographic characteristics, comorbidities and pulmonary function tests (PFTs) closest to the long-term chest CT scan were collected from medical charts. Chest CT scans performed at ICU admission, when available, were also reviewed for visual quantification of initial lung disease extent. Statistical analysis was performed using the statistical software package "R" (version 3. 2. 1, R Foundation, Vienna, Austria). Quantitative data is presented as median (interquartile range (IQR)) and was compared using a Kruskal-Wallis test by ranks.
The same year in Ireland, Lynch et al. described an average annual KD hospitalization rate of 15. 2 per 100,000 children  (23). Because a child could be hospitalized in several hospitals or several times during the same episode, this rate was an overestimation of the true incidence. In 1998, before publication of the AHA criteria and increased awareness of KD by physicians, Harnden et al. found an incidence of 8. 4 per 100,000 children by using administrative data  (24). Recently, Hall et al. found an incidence of 9. 1 per 100,000 children by using The Health Improvement Network database of electronic primary healthcare records from practices throughout the United Kingdom. This database has been shown to be generalizable to the UK population although with slightly fewer people aged <20 years as compared with the general UK population  (25).
of Annual period cases incidence rate Cimaz et al. (19) Italy 2008-2013 National hospital discharge record database 2,901 14. 7 Riancho-Zarrabeitia Spain 2005-2015 Hospital morbidity survey of the Spanish National Institute 3,737 11. 7 et al. (27) of Statistics (INE) database Piia Jogi et al. (28) Estonia 2008-2019 Hospital discharge records 85 9. 6 Hall et al. (25) United Kingdom 2008-2012 The Health Improvement Network (THIN) database 109 9. 1 Tulloh et al. (26) United Kingdom+ Ireland 2013-2015 Prospective surveillance 553 4. 6 Tacke et al. (29) The Netherlands 2008-2012 Prospective surveillance 341 5. 8 Jakob et al. (30) Germany 2011-2012 Prospective national surveillance (ESPED) + 272 7. 2-9. 6 cross-validation with hospital record data in 2 federal states.
On 17 th of December 2020, 127 cases of COVID-19 have been reported, most of them being enrolled in the PEDONCOVID study (NCT04433871). Eight patients required hospitalization in intensive care unit (ICU) and one patient with relapsed acute lymphoblastic leukemia (ALL) died from ARDS with multi-organ failure. Thus, SARS-CoV-2 infection can be severe in some children with cancer and /or HSCT, as suggested by the first reports from the SFCE  (21, 23)  or available through the St-Jude Research Hospital Registry (to which the SFCE is participating)  (24). (20, 23, 25, 26). Thus, the main threat to the vast majority of children with ALL still remains the ALL itself. Long-term data including well-matched casecontrol studies will tell if treatment delays/modifications due to Covid 19 have impacted the outcome if children with ALL.
General considerations Corticosteroids are a key part of induction therapy and, more generally, of ALL treatments. Initial outcomes of the use of corticosteroids in SARS-CoV-2 infection were controversial. Recent data suggested that dexamethasone is effective in severe COVID-19 in immunocompetent patients  (29). The benefit of using corticosteroids in immunocompromised patients with severe COVID-19 is less clear and has not been proven yet. Still, ALL is life-threatening and very probably more than COVID-19 in most situations. Thus, we consider that the risk-benefit ratio calls for regular protocol induction. However, chemotherapy doses and scheduled administration should be weighted with the clinical status and oxygen saturation of the patient, as well as the results of chest computed tomography scan, which should be performed in all patients during this induction phase.
Introduction With millions of fasteners needed to complete the A350, the challenge of mastering the tightening of bolted connections cannot be overlooked. The aim of this research work was to develop a predictive tool to better control tightening behaviour through the torque/tension relationship, integrating strongly non-linear local phenomena. Controlling the preload within the bolted assembly can be beneficial for the integrity of the aircraft  [1, 2]  but this tool developed for an industry 4. 0 which is geolocated and able to feed a dynamic database can also be an advantage for quality control and maintenance  [3]. However, the preload is a very dispersive variable  [4]  and is difficult to control in production with current clamping tools  [5]. One of the objectives is to optimize the tightening instructions that meet aeronautical requirements, in an uncertain environment  [6].
This initiative should minimize the cases of over-torque and under-torque and lead to an assessment of the risks implied for the tightening efficiency. It should also provide an understanding of the mechanical behaviour of fastening elements impacted by faults. However, if we consider all the parameters of a bolted connection, we obtain a total of approximately 7,050 combinations per diameter. Table  1  lists the number of possible parameter solutions, without taking compatibility into account, when we use a bolted assembly. Given the large number of possible combinations, the behaviour of bolted connections can only be understood by creating a large database, in particular using design of experiments (DOE). Many research works have aimed to develop methods of constructing designs of experiments that make it possible to obtain a maximum of information with a minimum of known points, whilst remaining robust with respect to random and approximation errors  [7].
In addition, for reasons of repeatability and reliability, 20 tests were carried out per combination, giving a total of 540 tests. For each combination, an average maximum breaking torque is extracted, which corresponds to the average of the torques for which there is loss of the preload in each repeatability test. Also, using the same principle, the average maximum preload is extracted and, as the torque/preload relationship is known to be very dispersive, the standard deviation of the two previous data is also noted.
SINGLE-PHOTON GENERATION AND MULTIPLE DATA SETS To study this benchmark, we used heralded singlephoton states generated using a two-mode squeezer, i. e. , a type-II phase-matched optical parametric oscillator operated well below threshold (see Appendix). The signal and idler photons at 1064 nm are separated on a polarizing beam-splitter and the idler photon is detected via a high-efficiency superconducting nanowire single-photon detector. This detection event heralds the generation of a single photon in the signal mode. The generated state is emitted into a well-defined spatio-temporal mode  [44] , with a bandwidth of about 65 MHz. The state is measured via high-efficiency homodyne detection, with a visibility of the interference with the local oscillator above 99%, and reconstructed via maximum-likelihood algorithms  [2].
The experimental setup has been described elsewhere  [1, 46]. Importantly, the OPO used in this work exhibits a close-to-unity escape efficiency, i. e. , the transmission of the output coupler is much larger than the intracavity losses  [48]. As a result, a large heralding efficiency can be obtained, i. e. , a very low admixture of vacuum. A single-photon component up to 91% is achieved. Also, by changing the pump power the multi-photon component can be increased at will. These features enable us to explore different combinations of state imperfections. Seven sets of data were recorded, each of them being obtained by a repetitive measurement of the single-photon states generated under the same conditions. Parameters of the sets are given in Table  I. They include the singlephoton component P 1 and the probability P 2+ of finding two or more photons.
This work was supported by the  European Union 's  Horizon 2020 research and innovation framework programme  under grant agreement No  731473  ( QuantERA ERA-NET Cofund in Quantum Technologies , project  ShoQC ), No  820445  ( FETFLAG Quantum Internet Alliance ), and  No 951737  ( Twinning project NonGauss ). This work was also funded by the  French National Research Agency  ( HyLight  project  ANR-17-CE30-0006 ). R. F. acknowledges grant  20-16577S  of the  Czech Science Foundation  and national funding from the  MEYS  (project  8C20002 ). G. G. acknowledges the support by the  European Union  ( Marie Curie Fellowship HELIOS IF-749213 ), T. D. by the  Région Ile-de-France  in the framework of DIM SIRTEQ, and P. Z. by the  European Union 's  Horizon 2020 research and innovation framework programme  under grant agreement No  732894  ( FET Proactive , project  HOT ).
Parameters were combined in nested loops with the beam-energy scan nesting the beam-intensity scan, which was nesting the temperature scan, which was nesting the bias voltage scan. A total of 49 datasets were acquired during the test beamtime. The size of the beam was measured at the focal plane and in a region of interest along the Z direction for each X-ray energy. This allowed the micro-strip sensor position, inferred from mechanical drawings, to be aligned with the focal plane of the CRL array. As the sensor is enclosed in the cryostat and cannot be seen from outside the Be window, it was estimated that +/-5. 0 mm uncertainty on the nominal position was a reasonable assumption. The beam-energy was set to three different values 10 keV, 15 keV and 20 keV to cover a large sub-range of the operational energy at ID24 (5-27 keV).
Charge-sharing for different X-ray energy and intensity The effect of energy and intensity of X-rays on charge-sharing is investigated in this section. A comparison between datasets is presented by plotting the FWHM of the charge-sharing profile as a function of integrated current. The integrated current can be used as a proxy for the intensity of the X-ray beam across different datasets. In fact, it was necessary to change the integration time of the front-end electronics during data collection in order to compensate the recorded signal for different beam intensities. The shortest integration time was set to 5. 0 μs and the longest was set to 500 μs. Therefore, it is not possible to simply compare values of integrated charge. Instead, it is necessary to consider the amount of time over which charge was integrated.
Hence, the integrated current was calculated by summing the charge recorded in a cluster of 9 strips around the seed and diving by the integration time. The feedback capacitor (10 pF) was kept constant in all datasets. A comparison of three beam energies is presented for different bias voltages: -50 V in Fig. 10 , -150 V in Fig. 11 (a), -180 V in Fig. 11(b). A higher voltage is more effective in containing the spread of the charge-sharing profile created by high intensity beams. The three different beams have comparable charge-sharing profiles at similar beam intensities. In the following paragraphs the signal current per unit area is used as a proxy to compare test-beam results with operational conditions at ID24. In this beamline, the highest flux is expected at 7 keV during a fill-pattern which is known as 4-bunch mode.
Acknowledgements The authors would like to acknowledge  STFC ,  United Kingdom  for funding this project ( RM03-FY19 ) via the  Centre For Instrumentation programme. They would also like to thank the  Diamond Light Source  for time on beamline  B16  under proposal MM24637-1. Finally, they express their gratitude to  A. Dent ,  F. Mosselmans  and  N. Tartoni  at the DLS for helping to organise the test-beam.
Our inelastic neutron scattering experiments performed at low temperatures show clear dispersive magnonic bands and a well-resolved bandgap opening at the high-symmetry K points in the Brillouin zone  (BZ). By fitting to experimental data within the linear spin wave theory (LSWT), the magnitude of exchange interactions in studied materials has been determined. Moreover, the observed bandgap opening was ascribed to the antisymmetric exchange interactions, namely, the DM interaction, and a spin Hamiltonian model including the second nearest-neighbor (2nd-NN) DM interaction could provide a very good description of the magnonic dispersion in CrXTe 3. In line with expectations, the size of the topological gap was found to be strongly dependent on the strength of the DM interaction that intrinsically originates from SOC in this system.
Besides, the strength of the DM interactions is fitted as |D ij | = 0. 12 meV for CrSiTe 3 and |D ij | = 0. 32 meV for CrGeTe 3 , which results in a ∼2and ∼5-meV gap opening at the K points, respectively. We remark that the magnitude of the DM interaction in CrXTe 3 constitutes about 10% of J ab1 , and it is quite comparable to the value of exchange J ab2 between 2nd-NN Cr ions. From the isothermal magnetization curve at 2 K (fig. S1 ), we can extract the magnetocrystalline anisotropy energy per Cr 3+ , which is only 0. 09 meV for CrSiTe 3 and 0. 02 meV for CrGeTe 3 , indicating a small single-ion anisotropy in the CrXTe 3 system. In terms of the small single-ion anisotropy, as expected, we failed to determine the size of the gap at the  point from our energy scan data directly, and we used instead the quadratic fitting result 0.
4E , our numerical estimates indicate that the thermal Hall conductivity generated by the edge states can reach the order of 10 -4 W K -1 m -1 , which is large enough to be observed in experiment. This motivates the future confirmation of topological thermal Hall effect in CrXTe 3 from thermal transport experiments. In summary, we carried out a very comprehensive inelastic neutron scattering study of the spin-wave excitations on the ferromagnetic honeycomb magnets CrXTe 3. Our data show a clear gap opening in the magnon bands at the K points, with the gap size of about 2 and 5 meV for CrSiTe 3 and CrGeTe 3 , respectively. The magnon band dispersion in CrXTe 3 can be described very well by either the Heisenberg-DM model or the Heisenberg-Kitaev model. The gap opening can be ascribed to the asymmetric DM interaction with an out-of-plane DM vector or Kitaev interactions.
Acknowledgments: We acknowledge  S. Mayr  for assistance with the crystal orientation. This work is based on the experiments performed at DNS, PUMA,  IN8 ,  IN12 ,  IN22 , and FLEXX neutron instruments. Funding: F. Z. acknowledges the funding support from the  HGF-OCPC Postdoctoral Program. Y. M. acknowledges the  Jülich Supercomputing Centre  and RWTH.
Study design CHIPPI-1808 (Chimiothérapie Hyperthérmique Intra-Péritonéale au cours d'une chirurgie Première ou Intervallaire) is an international, multicenter, open label, randomized (1 : 1), two-arm phase III clinical trial that will enroll 432 patients with newly diagnosed FIGO stage III EOC. This trial is registered in ClinicalTrials. gov (NCT03842982). The trial is organized and funded by the Oscar Lambret Cancer Center. It will take place in 16 tertiary cancer centers, 14 of which are in France and 2 of which are in Belgium. Institutional review board approval for the trial has been obtained. The inclusion and exclusion criteria are detailed in Appendix.
Simultaneously, patients receive an intravenous perfusion of sodium thiosulfate that is prolonged 6 h after the operation to prevent nephrotoxicity. 6 dpoints DFS is defined as the time from randomization to the date of progression, relapse or death from any cause. Progression and relapses are confirmed by the local tumor board, based on Gynecologic Cancer Inter Group criteria in combination with clinical, biological and radiological assessments. For patients alive without progression or relapse, data are censored at the date of the last follow-up visit. OS is defined as the time between randomization and death from any cause. For patients who are alive at the end of the study, data are censored at the date of last follow-up. Adverse events (AEs) are evaluated from randomization up to 30 days after the end of treatment (surgery or chemotherapy), excluding AEs unequivocally related to the disease or its progression.
AEs are classified according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE version 5. 0). AEs of grade !3 (grade 3þ) are considered severe. The impact of HIPEC on adjuvant treatment feasibility is evaluated by the time interval between surgery and the start of adjuvant chemotherapy. Chemotherapy is considered delayed when this interval exceeds 6 weeks. In this case, the reasons for the delay are described. The impact of HIPEC is also evaluated by evaluating the total number of chemotherapy courses (neoadjuvant and adjuvant); if it is less than the six planned courses, the reasons are described. Q-TWiST is computed from survival data (OS and DFS) and AE data (date of occurrence of grade 3þ AEs). The quality of life is evaluated using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Score 30 (QLQ-C30) and Quality of Life Questionnaire-Ovarian Cancer Module (QLQ-OV28).
euryzon or speciated from E. lequeuxi  [49]. In the Pacific Region, historical data on E. phalonia presence indicate that th spreading started in the middle of the 19th century, probably with an ancestral form [47 Among the 21 species of Eudocima, close morphologies are also observed between E phalonia and two newly described species, E. oliveri  (Zilli and Brou)  in Vanuatu and E steppingstonia  (Brou, Klem, Zaspel and Zilli)  in the Marquesas Islands  [47]. Unfortunately these two new species are described from specimens collected over the centuries, withou recent observations. Despite geographical proximity with Vanuatu, E. oliveri has neve been recorded from New Caledonia. This is also the case for the species E. jordani (Ho land)  [50]. Within this genus, three species are mentioned in New Caledonia, E.
Acknowledgments This work has been carried out within the framework of the  EUROfusion Consortium  and has received funding from the  Euratom  research and training programme 2014-2018 and  2019-2020  under grant agreement No  633053. The work received support from the  RCUK Energy Programme  [grant number  EP/T012250/1 ],  NIFS  budget  NIFS15KLPF045  and from  NRF Korea  grant no. 2014M1A7A1A03029881. The views and opinions expressed herein do not necessarily reect those of the  European Commission. ROD acknowledges the hospitality of  Kyushu University. BCGR acknowledges helpful discussion with  Dr. Carbajal-Gomez.
Studies selection The databases of PubMed, EMBASE, and Cochrane Library were searched by using the following terms: "immunotherapy", "nivolumab", "ipilimumab", "pembrolizumab", "atezolizumab", "tremelimumab", "avelumab", "durvalumab", "PD-1", "PD-L1", "CTLA-4", "immune therapy", "immune checkpoint", "immune checkpoint inhibitor", "immune checkpoint blockade", "combination immunotherapy", "carcinoma", "sarcoma", "neoplasm", "tumor", "cancer", "malignancy", and "randomized clinical trials", which were combined using "or" or "and" for relevant studies published on or before September 2019. Two reviewers independently screened articles for eligibility and extracted data from the included studies. All published phase 3 RCTs including patients with various tumors with at least one arm containing an ICI were included.
Data extraction and analysis The TRIO and 2004 CONSORT harms extension items referring to the toxicity reporting were identified  (Ioannidis et al. , 2004; Tsimberidou et al. , 2018). Derived from these recommendations, we adapted objective criteria to assess variations in adherence to the TRIO and CONSORT guidelines and the quality of toxicity reporting (Supplement 1). The TRIO Items 10 and 11 were subdivided as proposed by the TRIO statement. Spin, defined as a « specific intentional or unintentional reporting that fails to faithfully reflect the nature and range of findings and that could affect the impression of the results produce in readers », was assessed in the harm qualification profile in discussion  (Boutron and Ravaud, 2018). Descriptive statistics were used. Univariate or multivariate analyses were not performed.
More particularly, grade 4 AEs are defined as life-threatening toxicities and require urgent intervention whereas grade 3 gathers severe or medically significant, but not immediately life threatening AEs. In regards to grade 4 AEs, 13 trials (28 %) presented them solely, but no single article had neither more detailed information for grade 4 events nor management. Grade 5 AEs were reported by all studies included and their nature was specified in 100 % of them. Only two articles detailed patient characteristics and the events for all the treatment-related deaths in supplement. However information about the grade 5 AEs management was provided by only by one publication. The timing of onset, duration, and resolution were reported in 30 %, 28 %, and 26 % of the studies, respectively. When mentioned, these metrics could be reported solely for one or a few AEs and these data were not available for all  Abbreviations: AE, adverse event; IO, immunotherapy; irAEs, immune-related adverse events; TRIO, trial reporting in immune-oncology.
Other clinically-relevant ICIs toxicity reporting items Table  4  shows other than the TRIO or CONSORT recommendations criteria and how these were reported. The collection of patient-reported outcomes (PROs) and/or quality of life (QoL) analyses were planned and reported in the main publication in 93 % and 17 % of the trials, respectively. Trials assessed the QoL with one to four different questionnaires. The European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 (EORTC QLQ-C30) was used in 31 articles (74 %) and the EQ-5D (3 L) in 16 articles (38 %). An organ-specific questionnaire was used in 16 articles (38 %). For 25 articles (54 %), data on AEs occurring in less than 10 % of the patients were not complete. The highest cut-off under which AEs were not presented was 15 %.