dataesr/scientific-paragraphs-categorization huggingface dataset:
Data on tobacco and alcohol consumption were collected using two questionnaires : the smoking status identification (NIDA) and alcohol consumption (AUDIT-C). A questionnaire for socio-demographic data and two for psychological data (Thermometer of psychological distress; ESAS), have been used. The medical data were reported by participants and verified on medical records. Results > In a total of 11 months, 120 women with breast cancer were included in this study. A large majority of patients were hospitalized for a first-time cancer (80. 8%), type invasive ductal carcinoma (70. 8%) and were receiving surgery as primary treatment (45%). Furthermore, 30. 8% of the women reported tobacco consumption and 38. 4% high-risk alcohol consumption. Regarding mental health, 40. 8% presented moderate to intense levels of psychological distress.
Stimuli and materials Prior to participating in the studies, participants' voices were recorded while vocalizing the phoneme /a/ for approximately 1 to 2 s (Zoom H6 Handy recorder). Each recording was normalized for average intensity (-12 dBFS) and duration (500 ms) and cleaned from background noise (Audacity software). In detail, immediately before recording participants' voices, we recorded a few seconds of baseline background noise, that was filtered out from the vocalization. The 500 ms clips that were used as stimuli were selected from the utterance by avoiding its onset and offset, and additionally by selecting its most stable part (i. e. 500 ms that do not noticeably vary in sound intensity). Noise reduction parameters in Audacity software were set to default (12 dB, sensitivity: 6, smoothing: 3 bands).
This served as a stricter methodology, as it enables a better concordance in sound intensity and spatial location between the bone-and air-conducted stimuli. However, we did not formally quantify the extent to which the participants were able to determine the source of the auditory stimuli-this was only inferred from participants' reports. Despite this difference in air-conduction medium, i. e. loudspeakers (Study 1) versus headphones (Study 3), we observed similar effects in comparison with bone conduction in both studies (see Results). In all studies, we used the same Aftershokz Sportz Titanium headphones as bone-conducting medium. In all studies, inter-trial intervals jittered between 1 and 1. 5 s to avoid predictability of stimulus onset. All studies were performed in Matlab 2017b with Psychtoolbox library  [60].
Statistical tests were performed with R  [61] , using the lme4  [62] , lmerTest [63] and cocor  [64]  packages. The results were illustrated using sjplot  [65]  and ggplot2  [66]  packages. Power analysis was performed with simr  [67]  package. Bayesian models were created in Stan computational framework (http://mc-stan. org/) accessed with the brms package  [68].
The voice spaces were normalized such that the origin of the spaces corresponds to the other voice in each self-other voice pair. The distance to the origin thus represents the acoustic difference between self-and other voices. In detail, for each voice recording, we extracted the fundamental frequency (F0) and five formants (F1-F5) using Praat software  [74]  and computed its voice-space coordinates, corresponding to source (x coordinate) and filter (y) components of voice production  [73]  (males: x = log(F0), y = log(F5 -F4); females: x = log(F0), y = log(F1)). The choice of coordinates was based on the work by Bauman & Belin  [18] , who demonstrated that this combination of acoustic parameters best accounts for subjective discriminability of voices for each gender. As an exploratory analysis, we constructed several different voice spaces by using different acoustic parameters for the y-axis.
Résumé La maladie des emboles de cholestérol (MEC) est une maladie systémique, caractérisée par une ischémie tissulaire et une micro-inflammation, liée à l'occlusion des artérioles par des micro-emboles en provenance de plaques athéromateuses ulcérées. Le rein est parmi les organes les plus touchés avec souvent nécessité de recours à la dialyse. Les anticoagulants augmentant le risque d'emboles, la dialyse péritonéale peut avoir théoriquement un avantage. Notre étude examine le devenir d'une cohorte de patients avec MEC traités par dialyse péritonéale (DP). A partir de la base de données du Registre de Dialyse Péritonéale de Langue Française (RDPLF), entre le 1/1/1995 et le 31/12/2021, nous avons sélectionné les patients traités par DP depuis >90jours et ayant un âge >18 ans. Sur la base des variables suivantes : autonomie des patients, diabète, IMC, indice de Charlson modifié, âge, sexe, traitement avant DP, causes de décès, causes de transferts en hémodialyse et péritonite, trois types de survie ont été estimées (patient, technique stricte et technique composite).
Après ajustement par les scores de propension et prise en compte des risques compétitifs, 2 groupes de patients ont été constitués sur la base de la néphropathie de base : groupe emboles vs groupe autres. La survie patient et la survie technique stricte ne sont pas associées au type de néphropathie (MEC versus autres). La survie technique composite (non censurée pour les décès et transferts en hémodialyse) n'est associée à la néphropathie par emboles de cholestérol que dans l'analyse multivariée ajustée sur le diabète, l'autonomie et l'âge du patients au début de la dialyse (p=0. 011 ; IC95% [0. 736 [0. 581-0. 931]]). Notre étude à partir de la base de données du RDPLF montre l'absence de différence de survie technique et patient dans une cohorte de patients avec MEC vs un groupe contrôle.
Summary Cholesterol crystal embolisms disease (CED) is a systemic disease characterized by tissue ischemia and microinflammation related to occlusion of arterioles by microemboli from ulcerated atheromatous plaques. The kidney is one of the most affected organs, often requiring dialysis. Our study examines the outcomes of a cohort of patients with CED treated with peritoneal dialysis (PD). As anticoagulants can favor emboli, peritoneal dialysis may theoretically have an advantage. From the database of the French Language Peritoneal Dialysis Registry (RDPLF), between January 1, 1995, and December 31, 2021, we selected patients treated with PD for >90 days and with an age >18 years. On the basis of the variables of patient autonomy, diabetes, BMI, modified Charlson index, age, sex, pre-PD treatment, causes of death, causes of transfer to hemodialysis, and peritonitis, three types of survival were estimated (patient, technical, and composite).
After adjustment by propensity scores and taking into account competitive risks, 2 groups of patients were constituted on the basis of baseline nephropathy: emboli group vs. control group. Patient survival and strict technical survival are not associated with the type of nephropathy (CED versus others). Composite technical survival (uncensored for deaths and transfers to hemodialysis) was only associated with cholesterol emboli nephropathy in the multivariate analysis adjusted for diabetes, autonomy, and age of the patient at the start of the dialysis treatment (p=0. 011; 95% CI [0. 736 [0. 581-0. 931]]). Our study from the RDPLF database shows no difference in technical and patient survival in a cohort of patients with CED vs. a control group. It also confirms that PD may represent an adequate choice in this pathology.
PATIENTS ET METHODES Il s'agit d'une étude rétrospective observationnelle à partir de la base de données du Registre de Dialyse Péritonéale de Lange Française (RDPLF) dont la description et le mode de fonctionnement sont décrits par ailleurs  [15, 16]. Ont été inclus tous les patients de France métropolitaine, âgés de plus de 18 ans, insuffisants rénaux chroniques, qui avaient débuté un traitement par dialyse péritonéale depuis au moins 3 mois, entre le 1er Janvier 1995 et le 31 décembre 2021. Les patients traités par dialyse péritonéale pour syndrome cardio-rénal ont été exclus de l'étude. Deux groupes de patients ont été créés selon le diagnostic de la néphropathie principale : ceux dont l'insuffisance rénale était consécutive à une MEC (groupe Emboles) au nombre de 128, et ceux traités par dialyse péritonéale pour une autre néphropathie (Groupe Autre), au nombre de 15180.
METHODES ET ANALYSES STATISTIQUES Il s'agissait d'une étude de cohorte de vie réelle, la taille de l'échantillon a été déterminée par le nombre de patients inclus dans le registre du RDPLF et présentant un MEC. Les données démographiques, diagnostiques, clinicopathologiques et spécifiques à la maladie ont été récupérées prospectivement pour chaque patient entré dans la base de données. Les données manquantes pour les variables diabète (n=16 : 0,11%), traitement avant DP (n=63 patients : 0,42 %), autonomie (n=9 patients : 0,06 %) et Charlson modifié (n=3886 patients : 22%) ont été complétées par méthode d'imputation multiple à l'aide du package « mice » de R  [17]. Pour minimiser les écarts entre les caractéristiques de base significativement différentes entre les deux groupes étudiés, un appariement à l'aide d'un score de propension de rapport 1:1 a été effectué.
La base de données du RDPLF est déclarée à la Commission Nationale de L'Information et des libertés sous le numéro : 11950164795. Les données ont été exportées dans un fichier indépendant après anonymisation totale et irréversible. S'agissant de données rétrospectives à partir d'un registre le consentement écrit des patients n'était pas nécessaire pour l'étude. Aucune imputation n'a été faite sur l'IMC dont le nombre de variables manquantes (44%) était trop importante. Le Charlson modifié n'a pas été pris en compte pour le score de propension en raison d'un nombre trop important d'imputations dans le groupe embole (n=33). Ensuite, les différences moyennes standardisées (DMS) ont été calculées pour toutes les variables incluses dans le score de propension avant et après appariement pour évaluer l'effet de l'appariement sur le déséquilibre entre les groupes.
SI-4 Methodology for virtual measurements For the mandibular dimensions, 26 measurements were taken on the 3D models using Avizo, Fiji, and TIVMI (Treatment and Increased Vision for Medical Imaging) software. Using 3D landmarks or 2D slide extractions, virtual measurements were repeated three times at least one week apart. Results are provided in Table  S5. Differences between repeated measurements were negligible (all CV<5%, 19 being under 2%), the values obtained for each measurement were averaged and used to describe the mandibular dimensions in this study. In order to measure the mesiodistal and buccolingual crown diameters of the posterior teeth, a specific protocol was created using TIVMI. First, a path3D is created by placing a large set of points around the cervix of the tooth at regular intervals.
Acknowledgements Thanks to the municipality of Aventignan, the owner of the cave, and the not-for-profit organizations " Archéologies" and "Association pour le Rayonnement de l'Art Pariétal Européen " for their help during our excavations. Thanks also to  Monique Drieux  ( Materia Viva ) for her help during the cleaning of the fossil. SV thanks  Dominique Henry-Gambier  ( University of Bordeaux, CNRS, UMR 5199 PACEA ) for giving him the opportunity to study this fossil. Thanks to  Arnaud Mazurier  ( CNRS ,  UMR 7285 IC2MP ) for the acquisition of the 3D data and to  Erik Trinkaus  ( Washington University ) for sharing his data and for his helpful comments on the manuscript. This research was funded by the  French National Research Agency (ANR GRAVETT ' OS ,  ANR-15-CE33-0004 ). The excavations in Gargas were funded by the  French Ministry of Culture (DRAC Occitanie ) with support from the  Hautes-Pyrénées département council.
6  We now present data demonstrating the findings in a French-Canadian speaking sample. The entire study was undertaken in French. A sample of 49 pwMS and 29 age, sex, and education-matched healthy individuals were recruited from an outpatient MS clinic. Inclusion criteria included a neurologist-confirmed diagnosis of MS, ages 21-60 years, and no history of substance abuse, traumatic brain injury, severe mental illness, and other disease of the central nervous system. Informed consent was obtained from all participants. For the VR-SDMT, the computer begins by asking the participants for basic demographic information (age, sex, education level) and then administers an eye test to make sure the individual has corrected near vision (≤20/70). If the participant passes the eye test, the computer gives the VR-SDMT instructions and administers a practice trial before starting the test.
The increasing sophistication of voice recognition software made freely available to researchers by Google opens the door to the development of additional language versions of the test. This offers clinicians the opportunity to add a quick, reliable marker of cognition to their assessment and treatment of pwMS. Statement of Authorship. Author(s) and roles outlined. AF obtained funding; designed and conceptualized study; interpreted the data; drafted and revised the manuscript for intellectual content; approved final version of manuscript. LS programmed software (VR-SDMT); reviewed and revised the manuscript for intellectual content. JR programmed software (VR-SDMT); reviewed and revised the manuscript for intellectual content. CC played major role in the acquisition of data; reviewed and revised the manuscript for intellectual content.
CB played major role in the acquisition of data; reviewed and revised the manuscript for intellectual content. CM analyzed data; drafted and revised the manuscript for intellectual content. JP played major role in the acquisition of data; reviewed and revised the manuscript for intellectual content. EL designed and conceptualized study; reviewed and revised the manuscript for intellectual content. Conflicts of Interest. The author(s) declare the following potential conflicts of interest: AF reports grant support from the MS Society of Canada and the Canadian Institute of Health Research, book royalties from Johns Hopkins University Press, Cambridge University Press, Amadeus Press, and Glitterati Editions, and speaker's honoraria from Novartis, Biogen, Roche, and Sanofi-Genzyme. LS declares that there is no conflict of interest.
The Montpellier Metropolitan Area (MMA), an urban area in the south of France, presented itself as an interesting study field to investigate the impact of = food environment on dietary practices given the support of local politicians and interest in this specific issue. Accordingly, we aimed to examine whether retail food environment (RFE) was associated with the overall nutritional quality of food purchases in the MMA. In this study, the RFE was measured using multiple indicators (presence, number, relative density and proximity of six types of food outlet), and food purchases were assessed by objective purchasing data in French households. Beyond the scientific value of this work, which uses an original approach to assess RFE around the home and in activity space, our study might help guide cities looking to improve their RFE.
Study population This study was carried out as a part of the Surfood-Foodscapes project (https://www. foodscapes. fr/en), which was designed to assess the impacts of urban foodscapes on peoples' food styles in the MMA, the seventh-largest urban area in France. Analyses were conducted using data from the Mont'Panier cross-sectional study (https://www. etude-montpanier. com) and from the JArDinS study  [24]. Participants of both studies were recruited based on the same call for participation, targeting volunteer households living in the MMA. Both studies were carried out from May 2018 to December 2019, using the same data collection methods. Households in both samples had similar socioeconomic and demographic characteristics, and the results of sensitivity analysis with or without JArDinS households were also very similar.
We thus decided to keep the households from the JArDinS study in the final analysis sample in order to increase statistical power of analyses. In order to be included in the study, participants had to be 18 years or older, live in the MMA and participate at least to some degree in grocery shopping. Using sociodemographic data on the MMA from the French National Institute of Statistics (INSEE), we performed quota sampling based on household composition (one adult, multiple adults, one adult with at least one child, and multiple adults with at least one child), and age of head of household (< 30 years, 30-50 years and > 50 years). The Mont'Panier study and the JarDinS study were conducted in accordance with the guidelines laid down in the Declaration of Helsinki, and all procedures were approved by the Institutional Review Board of the French Institute for Health and Medical Research (IRB Inserm no.
Retail food environment assessment In this study, we focused on six different types of food outlet: supermarkets, markets (indoor and outdoor markets), greengrocers, bakeries, other specialized food stores (butcher's, fishmonger's and dairy stores) and small grocery stores. The classification of food outlet type was carried out based on SIRENE's food store classification. SIRENE is a French national business and establishment register database that is managed by the INSEE, recording the identity of all active companies and their establishments in France. In France, most meals are consumed at home, as highlighted in the Third French Individual and National Food Consumption report (INCA 3)  [25] , which is why we chose to focus on RFE for at home food consumption, excluding restaurants, fast-food outlets, etc.
We excluded food purchased to be consumed away-from-home when calculating the nutritional quality of households' food purchases for the same reason. The location of food stores was obtained through the SIRENE database. The SIRENE database provides information on the French directory of active companies and establishments. This database was first cross-checked using OpenStreetMaps  (OSM). OSM provides open data on companies and establishments that can be updated and enriched by external contributors. Online searches on Google Maps, company websites of the major food retailers, and city websites (e. g. with information on local markets) were then performed to further verify the database. Final verifications were carried out through field observations on around 5% of the area studied: the information provided on location and type of food outlet by the database was validated through ground-truthing in the city-region of Montpellier between May 2018 and January 2019  [26].
Nutritional quality of monthly food purchases In order to assess the food supplies of households, participants were asked to complete a food supply diary, in which they had to list all foods and drinks purchased (including online purchases), harvested, or received for at-home consumption, over a one-month period. Step-bystep instructions on how to complete the food supply diary was given to participants and also specified at the front of the diary. For each food purchase made, participants were asked to collect grocery cash register receipts. When grocery cash register receipts were not available, participants were asked to provide details of foods purchased, received or harvested (name, quantity and expense incurred when applicable). Missing data concerning expenses for food items were imputed using the INSEE database and price were found on food store websites.
Participant characteristics Two sets of data were used for this paper, 415 households participating in the Mont'Panier survey and 47 households in the JArDinS study  [24]. Analyses were conducted on households with complete data on RFE, food purchases and socioeconomic and demographic characteristics. After the exclusion of households with incomplete data, 462 households were included in the main analyses. Households composed of several adults without children were the most represented household structure in our study sample, income per consumption unit levels were relatively well distributed among the study sample, and over one third of head of households were aged between 30 and 50 years (Table  1 ). The distribution of socioeconomic and demographic characteristics of households is relatively close to that of the population census of the study area (INSEE 2017) as shown in Table  1.
Finally, selection bias may also be an issue in this study, since households that volunteered to participate in a study on dietary behaviors may initially be more interested in nutrition and thus be more inclined to make healthier food purchases. However, in order to limit selection bias, quota sampling was performed based on household composition and age of head of household. Moreover, purchases might not always reflect consumption  [58] , which could be seen as another limit of our study; however, our study did not attempt to use food purchases as a proxy for food consumption. Indeed, our aim was to assess the relationships between food environment and the nutritional quality of food purchases, not diet quality. It may, nonetheless, prove to be a limit for comparison with other studies, which are using individual food consumption data and not household food purchasing data, as we did.
Acknowledgments We thank all of the participants of the Mont'Panier study and we thank the members of the  Surfood-Foodscapes (Sustainable Urban Food Systems-The effects of urban foodscape on food styles in Montpellier Metropole ) project. The following authors were part of the Surfood-Foodscapes working group:  Caroline Mejean 1 , Christophe Soulard 2 , Coline Perrin 2 , Daisy Recchia 1 , Emmanuelle Cheyns 1 , Geraldine Chaboud 1 , Marion Tharrey 1 , Marlène Perignon 1 , Nicolas Bricas 1 , Nicole Darmon 1 , Olivier Lepiller 1 , Pascale Sheromm 2 , Pascaline Rollet 1 , Simon Vonthron 2. Affiliations: 1 MoISA ,  Univ Montpellier, CIRAD, CIHEAM-IAMM ,  INRAE ,  Institut Agro ,  IRD , Montpellier, France; 2  INNOVATION ,  Univ Montpellier ,  CIRAD ,  INRAE ,  Institut Agro , Montpellier, France.
This work was carried out as part of the first author's (DR) PhD funded by  Region Occitanie and Institut national de recherche pour l'agriculture , l'alimentation et l'environnement (INRAE). The project " Sustainable Urban Food Systems -The effects of urban foodscape on food styles in Montpellier Metropole (Surfood-Foodscapes )" coordinated by  Cirad, Inrae , and  Montpellier Supagro , was publicly funded through  ANR  (the  French National Research Agency)  under the " Investissements d'avenir " programme with the reference  ANR-10-LABX-001-01 Labex Agro  and coordinated by  Agropolis Fondation. The project Mont'Panier « Relations entre paysages alimentaires et pratiques alimentaires », was also funded by  Region Occitanie ,  Dispositif REVE « REcherche  et Valorisation Economique ». The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of this manuscript.
Study design and patients We describe unrelated patients with clinical FH who underwent genetic analyses. None had been identified via cascade testing following a diagnosis of FH in a relative. All had been referred to specialist physicians (principally endocrinologists, cardiologists, and pediatricians) of the Bordeaux University Hospital between October 2009 and December 2019. Patients who underwent monogenic FH genetic testing were retrospectively selected (regardless of outcome). Written informed consent was obtained from all patients or their legal representatives. We adhered to the requirements for protection of personal health data and privacy set out in Article 65-2 of the (amended) Data Protection Act and the General Regulation on the Protection of Personal Data. The study was approved by our institutional ethics committee (CHU Bordeaux, France).