dataesr/scientific-paragraphs-categorization huggingface dataset:
Patients and methods We conducted a retrospective multicenter study using comprehensive administrative hospital discharge databases of the Centre Val de Loire region, France (2. 5 millions of inhabitants). Based on an ICD-10 algorithm, we included all adult patients admitted in an ICU for septic shock or acute respiratory distress syndrome (ARDS) during 2011 and invasively ventilated at least 5 days. Performance of the selection algorithm was validated through review of a subsample of medical charts. Comorbidities were also extracted from ICD-10 coding and reported using a scoring system derived from Charlson Comorbidity Index. Healthcare use and comorbidities were analyzed 2 years before (pre-ICU period) and 2 years after ICU (post-ICU period). Results 552 patients were selected, of which 249 (45%) died during the hospital stay.
Patients and methods We designed a case control study in three ICUs belonging to the Outcomerea research group (July 2014-May 2015). Case patients were adult patients ventilated for more than 48 h. We excluded patients not speaking or understanding French and patients who denied participation. Clinical and demographics characteristics of the cases were extracted from the Outcomerea database. They were interviewed 6-months after ICU discharge. Control patients, matched on age and sex and never hospitalized in ICU, were interviewed faceto-face during an hospital consultation. All patients completed the same questionnaires in a random order, exploring emotional and post traumatic-stress syndrome (Impact of Event Scale-revised, cut-off >22), self-sufficiency in daily activities (activity of daily Living, ADL), quality of life (first question of the SF-36), and questions about their place of living, of working and financial conditions, need of psychological help and marital status.
Introduction The harmfulness of fluid-induced hyperchloremia (H-Cl) remains debated. Large randomized trial showed that chloriderich crystalloids did not worsen outcome  [1]. The volume of fluids, however, was limited and the incidence of H-Cl was not recorded. Patients and methods In a post hoc analysis of the database of the RCT "Hyper2S", a study comparing normal to 3% hypertonic saline for 72 h in 434 patients with septic shock, we assessed the incidence and the impact of H-Cl (≥110 mmol/L) on adverse events and mortality. Cl, pH, bicarbonate (Bic) and lactate (Lac) were recorded at H0- Results 413 patients without missing data were analysed. H-Cl and HCl-acidosis were recorded in 257 (62%) and 77 (19%) patients, respectively, H-Lact and H-Lact-acidosis in 294 (71%) and 209 (51%) patients, respectively.
Patients and methods Observational prospective study, conducted in 2 of the 8 centers participating in a randomized, controlled, doubleblind, multicenter trial (PRETTINEO study, ClinicalTrial. gov identifier NCT01490580). Patients were randomly assigned (1:1) between "atropine-propofol" and "atropine-atracurium-sufentanil" before elective or semi-urgent intubation in the neonatal intensive care unit. Randomization was stratified on weight and center. Exclusion criteria included low blood pressure defined as a MABP (in mmHG) below gestational age (in weeks). Physiological parameters, including pulse oxymetry (SpO 2 ) and regional cerebral oxygen saturation (rScO 2 ), were collected 1 min prior to induction of anesthesia, and then up to 60 min after. To investigate the balance between oxygen delivery and consumption, cerebral fractional tissue oxygen extraction (FTOE) was calculated as FTOE = (SpO 2 -rScO 2 )/SpO 2.
Infection appeared mainly monobacterial as usually described in children but gram-negative strains are emerging. Mortality was still low and sequella were rare. Conclusion Cellulitis (CEL) and Necrotizing Fasciitis (NF) are still rare in childhood, with low mortality and few sequella if aggressive treatment including surgery is emergently performed. However, it seems that epidemiology has changed during the last decade in high-income countries. Statistical analysis of this database is ongoing to identify predictors of surgical requirements and to describe more precisely bacterial strains involved.
The "musical intervention" subjects received a 30-min L-type music session with the MUSIC CARE© software (2), with a sleeping mask concealing the eyes. The "sensory deprivation" group had the sleeping mask and the insulating around-ear headphone, during a 30-min period. The "NIV alone" group had their NIV conducted as it is usually in our ICUs. The main objective was to determine if a musical intervention improved NIV tolerance, measured by respiratory comfort, and ventilation parameters at 30 min of NIV in comparison to conventional care. The respiratory comfort was assessed by a nurse or nurse assistant blinded to the treatment arm with a numeric visual scale (from 0 to 10) at the initiation (T0), after 30 min (T30), and at different time points of each NIV session. The primary endpoint was the change in respiratory comfort at initiation and after 30 min of the first NIV session.
Patients and methods We did this randomised, controlled, singlecenter trial with assessor-blinded outcome assessment in patients admitted to ICU. Hypoxaemic patients requiring orotracheal intubation for respiratory failure were randomised to receive preoxygenation using HFNC [flow = 60 L/min, fraction of inspired-oxygen (FIO 2 ) = 100%] combined with NIV (pressure support = 10 cmH 2 O, positive end-expiratory pressure = 5 cmH 2 O, FiO 2 = 100%) in the interventional-group or using NIV alone in the reference-group (Fig. 6 ). The primary outcome was the minimal oxygen saturation (SpO 2 ) during the intubation procedure. Secondary outcomes were intubation-related complications and ICU-mortality. The OPTINIV trial was registered with ClinicalTrials. gov, number NCT02530957. Results Between July-2015 and February-2016, we randomly assigned 25 and 24 patients in the interventional and reference groups.
Materials and methods It was a Single-center retrospective study performed in the teaching department of emergency and intensive care medicine in Zaghouan in Tunisia conducted between 1st January 2015 and 31th December 2015. All patients admitted in our ICU for acute exacerbation of COPD were enrolled in the study. Anamnestic characteristics, primary diagnosis, mode of mechanical ventilation were noted. The results of laboratory tests, blood gas data and the outcome of patients were also collected. Results 40 patients were included in the study. The mean age was 68 ± 11 years with a sex ratio of 4 (32 males and 8 females). The mean SAPS II score was 35 ± 10 with an APACHE II mean score of 22 ± 5. The most common cause of COPD in our patients was tobacco smoke with a mean consumption of 32 ± 10 pack-year history of smoking.
Patients and methods In a prospectively collected database including consecutive patients admitted between 2000 and 2012 for hypercapnic COPD exacerbation in our ICU, we calculated bicarbonate concentration change during ICU stay as follows: ΔHCO 3-= [HCO 3-] at admission -[HCO 3-] at discharge. Patients were split into 3 groups: • Group 1: Decreased bicarbonate levels: ΔHCO 3-≤ -5 mmol/l, • Group 2: Small change in bicarbonate levels: -5 < ΔHCO 3- < +5 mmol/l, • Group 3: Increased bicarbonate levels: ΔHCO 3-≥ +5 mmol/l. Long-term patient's status (surviving or deceased) was checked by consulting the register of civil status. Results During the study period 440 patients were consecutively admitted for hypercapnic COPD exacerbation (84. 5% males, median age: 68 years, median pH at admission: 7.
None. Introduction COPD patients have often polyglobulia because of associated hypoxemia especially in patients at the stage of chronic respiratory failure. Little is known about the prevalence of anemia and its impact on prognosis in patients with severe AECOPD admitted to ICU. The aim of this study was to determine the prevalence of anemia in AECOPD patients and its impact on prognosis. Patients and methods In a prospectively collected database including consecutive patients admitted between 2007 and 2015 for AECOPD in our ICU, we retrospectively assessed hemoglobin levels at ICU admission. Anemia was defined according to WHO criteria: Hb < 13 g/dl in males; Hb < 12 g/dl in females. Continuous variables expressed as median (25-75 percentiles interquartile ranges, IQR) and compared with the Mann-Whitney test.
Were included, the ICU patients who had hemodynamic and/or respiratory failure and how required the use of hemodynamic exploration. Exclusion criteria were age less than 18 years and the lack of data on the medical record. Outcomes: diagnostic utility was judged on the consistency and quality of data interpretation, therapeutic usefulness on the therapeutic changes and favourable response following these therapeutic adjustments during the 1st 24 h of monitoring, and prognostic assessment was judged on the ventilation period, length of stay and mortality. Results 131 cases of hemodynamic monitoring were included (PAC/PiCCO: n = 71 and common tools: n = 60). The superiority of the invasive monitoring was objectified with the consistency of interpretation of the collected parameters (91. 5 vs 78.
Materials and methods We investigated all patients underwent VA-ECLS after cardiac surgery between January 2013 and December 2014, all included in the SARIC database. The infection of inguinal cannulation site was defined as an inflammatory or purulent appearance of the cannulation site associated with a positive quantitative culture of the cannulation site sample. The «infected» and «non-infected» patients were compared by Wilcoxon or Fisher tests. A test of Log Rank and a Cox model was used for univariate and multivariate analysis. Results At all, 142 patients were investigated. Diagnosis of cannulation infection site was made in 38 (27%) patients. The median time to infection was 10 days [8; 15] (Fig. 21 ). Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli and Enterobacter cloacae were identified in 16, 12, 12 and 10% respectively.
The tariffs of reimbursement for the different DRGs and for the extra funding are updated every year. We measured the impact of these updates on the income of our ICU. Patients and methods DRG and length of stay of all the patients hospitalized during 2011 in our 12-bed ICU were extracted from the administrative database of our institution. We computed the reimbursement for the care of these patients with the tariffs of Productivity gains are necessary to cope the tariff evolution and may require reduction of costs, increase of activity and pricing optimization. Introduction Hemorrhagic complications during placenta previa are unpredictable and may indicate an extremely urgent C section. Our study goal is to determine the risk factors and prognosis of this urgent situation. Patients and methods This is a case-control study, prospective and analytic over the second semester of 2015.
Materials and methods We conducted a retrospective cross-sectional study based on hospital discharge databases (HDDs) from January 1, 2006 to December 31, 2014. We selected patients over 18 years old (y-o) who were hospitalized for ARI in a French region (Centre Val de Loire region, 2. 5 million inhabitants, served by one university hospital, one regional hospital and 37 general and private hospitals). Cases of ARI were extracted from the HDD with an algorithm based on ICD-10 specific diagnosis codes, taking into account the type, number and position of these codes in the hospital discharge report. We previously validated the ICD-10 case definition reviewing a sample of medical charts as the gold standard. Giving the acceptable accuracy and precision of our algorithm, the following data were extracted from the Importantly, the rate of ICU-hospitalization among hospitalized patients for ARI increased on the study period: 11% in 2006 whereas it was superior to 17% since 2010.
We conducted a one-center prospective observational cohort pilot study (www. ClinicalTrials. gov Identifier NCT02790567), included all consecutive patients admitted in our SICU between October 2013 and May 2015 and suspected to have HIT. Non-inclusion criteria were pregnancy, age <18 years old and treatment with fondaparinux. The day the diagnosis of HIT was suspected, the HEP and the 4T scores were calculated and the following blood analyses were performed: the ID-PaGIA Heparin/PF4 test, the ELISA test, the heparin-induced-platelet-aggregation (HIPA), and the serotonin release assay (SRA). After completion of the study, all medical files were reviewed by a multi-disciplinary independent committee to discriminate patient having (HIT group) or not (SAFE group) a HIT. The final diagnosis was based on the medical history of the patient, on the time-variation of the platelet count while heparin was discontinued or not, and on the results of the venous Doppler of the 4 limbs.
1, Mathilde Neuville 2 , Simon Bourcier 3 , Julien Mayaux 4 , Damien Contou 5 , Yacine Tandjaoui-Lambiotte 6 , Vincent Das 7 , Benjamin Zuber 8 , Stéphane Gaudry 9 , Guillaume Voiriot 10 , Mikael Alves 11 , Eric Maury 1 , Naïke Bigé 11Réanimation médicale, Hôpital Saint-Antoine, Paris, France; We performed a retrospective multicenter study including all patients admitted for cryptococcosis from January 1998 to March 2016 to one of the 11 participating ICUs. Admissions were identified through a systematic review of ICUs databases using ICD-10 code B45. Diagnosis was confirmed either by cryptococcal antigen detection in serum, cerebrospinal fluid, bronchoalveolar lavage or urine, or by the identification of Cryptococcus in the culture of a specimen of any site or by histology. Qualitative and quantitative values are expressed as number and percentage, and median and ROYBSIs) are rare, even in intensive care unit ICU.
Candida lipolytica candidemia is a rare but an emerging pathogenic yeast infection in humans. It can gain access to the bloodstream through intravascular catheterization, especially through central venous catheters in immunocompromised or critically ill patients during hospitalization. Patients and methods We retrospectively reviewed all episodes of unusual cases of Y. lipolytica fungemia occurred between October 2012 and June 2014 in the intensive care unit (ICU) of the UH Habib Bourguiba Sfax Tunisia. Underlying diseases, predisposing factors, laboratory data, and outcome were analyzed. Claire Dupuis 1 , Lila Bouadma 2 , Stephane Ruckly 3 , Anne Perozziello 3 , Bruno Mourvillier 4 , Sébastien Bailly 5 , Romain Sonneville 6 , Jean-François Timsit 7 1 Réanimation médicale, CHU BICHAT, Paris, France; 2 Réanimation médicale et des maladies infectieuses, Hôpital Bichat-Claude Bernard, Paris, France; 3 Umr 1137, Faculté de Médecine Xavier Bichat, Paris, France; 4 Réanimation Médicale et Infectieuse, GH Bichat Claude Bernard, Paris, France; 5 Equipe 11, Institut Albert Bonniot -Inserm U823, La Tronche, France; 6 Service de réanimation médicale et infectieuse, Hôpital Bichat-Claude Bernard-APHP, Paris, France; Patients and methods We analysed the occurrence of sepsis from 2009 to 2014, in adult patients, using the national French hospital Database PMSI (Programme de Médicalisation des Systèmes d'Information).
This database collects annually, for each hospital stay in France, a uniform hospital discharge record including diagnostic codes according to the International Classification of diseases, Tenth revision, Clinical Modification (ICD-10th-CM) and procedure codes according to the CCAM (Classification Commune des Actes Médicaux). Cases were identified from discharge records in the PMSI database. Septic shock was defined by a combination of a principal or accompanying diagnosis of infection (ICD-10thCM) plus a diagnosis code for septic shock (R572, R578, R579) or the procedure code EQLAFF03 (infusion of vasopressors). Charlson index were determined using diagnosis codes as previously described[1]. Costs were determined according to the National Reference Costs (ENC = Etude Nationale des Couts).
Temporal trend were assessed by calculating the value of the entire variable by year and compared using linear regression variables or Cochran Armitage Trend Test for continuous and categorical variables respectively. Conclusion SC incidence increased in France. Nearly 75% of the cases were managed in non-affiliated university centre. Although the overall mortality rates in patients with SC is slightly decreasing in France, the number of deaths related to SC in France is growing. Results must be interpreted with caution because of the limits related to administrative databases. However, the trends are comparable to data from other countries. IntroductionSince 2015, Zika virus (ZIKV) infection is spreading across South and Central America. The outbreak reached the Caribbean in the early 2016.
in France from 2009 to 2014: incidence, outcome, and associated costs of care 1, Mathilde Neuville 2 , Simon Bourcier 3 , Julien Mayaux 4 , Damien Contou 5 , Yacine Tandjaoui-Lambiotte 6 , Vincent Das 7 , Benjamin Zuber 8 , Stéphane Gaudry 9 , Guillaume Voiriot 10 , Mikael Alves 11 , Eric Maury 1 , Naïke Bigé 11Réanimation médicale, Hôpital Saint-Antoine, Paris, France; We performed a retrospective multicenter study including all patients admitted for cryptococcosis from January 1998 to March 2016 to one of the 11 participating ICUs. Admissions were identified through a systematic review of ICUs databases using ICD-10 code B45. Diagnosis was confirmed either by cryptococcal antigen detection in serum, cerebrospinal fluid, bronchoalveolar lavage or urine, or by the identification of Cryptococcus in the culture of a specimen of any site or by histology.
Qualitative and quantitative values are expressed as number and percentage, and median and ROYBSIs) are rare, even in intensive care unit ICU. Candida lipolytica candidemia is a rare but an emerging pathogenic yeast infection in humans. It can gain access to the bloodstream through intravascular catheterization, especially through central venous catheters in immunocompromised or critically ill patients during hospitalization. Patients and methods We retrospectively reviewed all episodes of unusual cases of Y. lipolytica fungemia occurred between October 2012 and June 2014 in the intensive care unit (ICU) of the UH Habib Bourguiba Sfax Tunisia. Underlying diseases, predisposing factors, laboratory data, and outcome were analyzed. Claire Dupuis 1 , Lila Bouadma 2 , Stephane Ruckly 3 , Anne Perozziello 3 , Bruno Mourvillier 4 , Sébastien Bailly 5 , Romain Sonneville 6 , Jean-François Timsit 7 1 Réanimation médicale, CHU BICHAT, Paris, France; 2 Réanimation médicale et des maladies infectieuses, Hôpital Bichat-Claude Bernard, Paris, France; 3 Umr 1137, Faculté de Médecine Xavier Bichat, Paris, France; 4 Réanimation Médicale et Infectieuse, GH Bichat Claude Bernard, Paris, France; 5 Equipe 11, Institut Albert Bonniot -Inserm U823, La Tronche, France; 6 Service de réanimation médicale et infectieuse, Hôpital Bichat-Claude Bernard-APHP, Paris, France; Patients and methods We analysed the occurrence of sepsis from 2009 to 2014, in adult patients, using the national French hospital Database PMSI (Programme de Médicalisation des Systèmes d'Information).
Results 288 neutropenic patients were included in the study. 201(70%)didnotreceiveG-CSFduring the first 48 h of ICU stay. patients'medicalchart and the hospital's electronic database. Specific complications of TMA-therapies were specifically sought. Data are presented as numbers (%) and medians (interquartile range). Groups were compared using non-parametric statistical tests (Chi square test or Mann-Whitney). Results During the study period, 124 critically ill TMA patients were recruited. There were 79 (64%) females, aged 44 years old (32-55). The TMA etiology included TTP in 81 (65%) cases, HUS in 24 (19%) and other TMA in 19 (15%) cases. Among the 81 TTP patients, 58 (72%) were females aged 42 years old (27-53). At diagnosis 66 (83%) patients presented with neurological symptoms, 50 (62%) with cardiac anomalies (whether clinical, EKG or biological anomalies), 46 (56%) with renal dysfunction, 28 (35%) with digestive symptoms.
Consulting additional bibliographic databases including gray literature, scientific meeting abstracts and review of the bibliography of selected articles completes the research. Inclusion criteria: (1) description and/or modification of an SAH model in rats or mice; (2) study of cerebral vasospasm and/or DCI. This research is performed in accordance with the PRISMA recommendations[2]. Results Seventy-one publications from 47 teams are included. 11teams are responsible for 77% of publications. 8different methods are used for induction of SAH. of the healthcare team and their families, given the socio-economic impact of the transplant. Our study's aim was to evaluate our potential organs donors from deceased patients in pediatric intensive care during 2015. Materials and methodsWe led a retrospective study in pediatric intensive care unit of UHC Ibn Rochd child hospital Abderahim Elharouchi of Casablanca, over 1 year from 1.
imaging, data of the first day in paediatric intensive care unit before codes on the death certificates. was used to performed descriptive and analytic statistic. Pearson ECMO initiation, complications, causes of death, characteristics of Databases of the French National Institute for Economical and Statisti- correlations were performed and Receiver operative characteristic ECMO group, surgical parameters and evolution of survivors after 1 cal Studies (INSEE) are available freely (www. insee. fr). Data regarding curves were built. Bootstrap technic was used to compute confidence month of life were recorded in the national database for congenital the characteristics of the French population, by region, year, sex and interval (CI). p < 0. 05 was considered significant. diaphragmatic hernia and patients' charts.
The role of NOX enzymes has been investigated in many models of neurodegenerative diseases by using either genetic or pharmacological approaches. In the present review we provide a critical assessment of recent findings related to the role of NOX in the CNS as well as how the field has advanced over the last 5 years. In particular, we focus on the data derived from the work of a consortium (Neurinox) funded by the European Commission's Programme 7 (FP7). We discuss the evidence gathered from animal models and human samples linking NOX expression/activity with neuroinflammation in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Creutzfeldt-Jakob disease as well as autoimmune demyelinating diseases like multiple sclerosis (MS) and chronic inflammatory demyelinating polyneuropathy (CIDP).
NOX2 and NOX4 are the main NOX isoforms expressed in the CNS Remarkably, NOX expression data indicate that under physiological conditions most NOX isoforms are expressed only to a negligible extent in the CNS. Specifically, qPCR shows that NOX1, NOX3, NOX5, DUOX1 and DUOX2 are undetectable or at the limit of detection in the human brain as well as in the mouse spinal cord and cerebral cortex  [24, 25]. NOX4 is detected in CNS tissue , and RNAseq data indicate that it is expressed mostly in the mouse endothelium, while very low amounts are also present in fetal astrocytes and oligodendrocytes. Similarly, NOX1 and NOX5 are expressed in the vasculature  [27] , but no clear evidence indicates that they are present in CNS parenchyma. Interestingly, DUOXA1 was detected at high levels in the CNS by qPCR and RNAseq, most likely in microglia, however only in the mouse brain  [24, 25].