dataesr/scientific-paragraphs-categorization huggingface dataset:
We evaluate the probabilistic skill in forecasting the presence of ice by plotting reliability diagrams for each region, alongside the Brier Skill Score (BSS) and reliability and resolution components of the Brier Score for the event of SIC in the grid cell exceeding 0. 15. The probabilistic forecasts are evaluated after bias correcting or trend-adjusting the SIC data as previously described for the Pan-Arctic SPS. Since over the 1993-2014 period, most of the Barents-Kara Seas region is ice-free in September, we show results for the Beaufort-Chukchi and Laptev-East Siberian Seas regions only. Results for the C3S operational re-forecasts and the C3S MME for September over the Beaufort-Chukchi region are shown in Fig. 9. Comparing the top and bottom rows, we find that trend adjustment improves the reliability and resolution of the forecasts.
Dirkson et al. (2019b)  found additional improvements in terms of probabilistic skill scores when fitting the sea ice concentration distribution to a parametric distribution and applying a trend-adjusted quantile mapping correction. These methods would likely further enhance skill scores of the systems evaluated in this study. However, given the coarse common spatial resolution used, the restricted number of re-forecast years, and the same statistical treatment applied to our benchmark forecasts, we are confident the bias and trend adjustment applied yield results that are representative of the actual capacity of these models to forecast summer Arctic sea ice over simple empirical approaches. Another source of possible error in the estimation of skill levels is the reference data used. The NSIDC data is known to have some uncertainties, in particular during the summer season where melt ponds can be interpreted as ice free areas, but was chosen so as to provide a fair comparison between systems (since none were initialized directly from this dataset).
The diverse levels of skill likely arise from differences in the sea ice initialization and modeling strategies, as suggested by recent works on the S2S scale by Zampieri et al. (  2018 ) and  Wayand et al. (2019). In particular, the results found for re-forecasts based on CNRM-CM (either CNRM-CM6-1 or MF-Sys6) show substantially lower skill than in previous studies (e. g. Chevallier et al. 2013). Ongoing evaluation of these systems show that they exhibit from the first month of the re-forecasts lower sea ice thickness than reference datasets. The initialization of sea ice thickness has been identified by recent works as a source of predictability on seasonal time scales, either by direct assimilation  (Blockley et al. , 2018)  or constraining SIT with SIC  (Kimmritz et al. , 2019). Other important processes for the melt season, such as melt ponds, are still only partially represented in models used in this study.
Acknowledgements and data This study was partly funded by the  H2020 - APPLICATE  project,  EU  grant number  727862. Copernicus C3S seasonal re-forecast data for ECMWF SEAS5, Met Office GloSea5 and Météo-France System 6 were retrieved using the Mars API. The reforecasts with the EC-Earth 3. 2 and CNRM-CM6-1 models were run as part of the  H2020 - APPLICATE  project and data is available on the APPLICATE data portal or upon request. JCAN acknowledges the  Spanish Ministry of Science, Innovation and Universities  for the personal grant  Juan de la Cierva   FJCI-2017-34027 ,  PRACE  for awarding access to  MareNostrum at Barcelona Supercomputing Center (BSC) , and  ESA/CMUG-CCI3  for financial support. PO work was funded by the  Ramon y Cajal  grant  RYC-2017-22772. The authors wish to acknowledge  F.
Data-Collection Method Data concerning the development of waste-flows circulation on the territory of Saint Martin after the passage of hurricane Irma, in 2017, were collected at the time of two missions carried out in May 2018  [40]  and May-June 2019  [41]. Sixty semi-structured interviews were carried out with public stakeholders in waste management, crisis management and regional planning, with building and public works contractors who worked on post-Irma waste management and with private actors in waste management, public services and associations for the protection of the environment (14 interviews in 2018 and 46 interviews in 2019). These interviews were supplemented by discussions with the population in the context of formalized questionnaires (63 inhabitants questioned in 2019) or of semi-structured interviews (16 inhabitants questioned in 2018).
Acknowledgments: The authors thank to all the local public, private stakeholders as well as the civil society and the citizens of  Saint Martin  that offered us valuable information and support during the field research mission. The authors are also grateful to all the partners of the  ANR DéPOs project: Gustave Eiffel University, Le Mans University, Avignon University ,  IFSTTAR ,  Robin des Bois Association and University of Mons  (associated international partner).
First, there are studies of assessment methods that could potentially provide important data on one or more phenotypes. For example, one may develop a new imaging technique to assess the glycosaminoglycan content of articular cartilage. Second, hypothesis-generating studies aim to determine which characteristics identify people in clinically important subgroups. For example, a biochemical marker level could be higher in a particular subgroup of knee OA patients. Third, hypothesis-testing studies test a priori hypotheses about subgrouping effects in samples of people independent from, but similar to, those people involved in the hypothesis-setting phase. Studies in this phase typically follow a more stringent approach than those at the hypothesis-generating stage. For example, the biochemical marker is now evaluated in a larger, well-characterized patient sample and might include healthy controls.
Basic definitions and statements We used the Delphi Decision Aid hosted on the ForecastingPrinciples. com website that was originally developed by J. Scott Armstrong (University of Pennsylvania). It is managed by Kesten C. Green (University of South Australia), and the software is maintained by Saint Louis Integration (stlouisintegration. com). An initial set of statements was developed by the core group. Statements were based on points that became apparent from literature data on OA phenotypes  [1, 4]  and phenotype studies in other diseases  [3, 5]. All panel members were then invited to score every statement on a range from 0 to 100% (0% meaning no agreement and 100% meaning complete agreement) and provide comments to explain and contextualize the scores. They could also suggest additional statements.
General study characteristics Currently, most datasets used for OA phenotype research are datasets from other studies or trials that are then secondarily used for phenotyping. Knowledge about the setting and characteristics of the original study are important for proper interpretation of the outcomes of the subsequent phenotype analysis. The original study goals and design will determine the contents of the dataset and the potential outcomes of the phenotype analyses. For example, opportunities for phenotype analysis in a dataset that is originated from a clinical trial will be different from analyses performed with data from an observational study. In keeping with this concept, some researchers may investigate phenotypes that differ in response to treatment, while others may explore phenotypes that differ in natural disease course.
g. , pain, function) Structural OA characteristics (e. g. , radiographic parameters) Data collection Variable(s) for the assumed pathobiological and/or pain mechanisms under study • Explanation of how and why the variable(s) is (are) anticipated to reflect the mechanism(s) • Statement of the quality of the variable(s), when available Follow-up time points for each of the variables (longitudinal studies) Outcome parameter(s) (i. e. , structural and functional consequences of the phenotype(s)) Statistical analysis Availability of a prespecified statistical analysis plan Analytical approach (supervised, unsupervised*) and rationale Power, sample size considerations Methods to adjust for potential confounders/effect modifiers and to handle missing data Criteria for the distinction between phenotypes and whether these were predefined Criteria for clinical relevance and/or applicability and whether these were predefined Any sensitivity analyses Methods to determine reproducibility/consistency Availability of datasets and syntaxes to other investigators (e.
g. , website, contact details) Appraisal Underlying pathobiological and/or pain mechanisms Potential clinical relevance and applicability Internal validity, potential sources of bias External validity, generalizability Comparison with other phenotype classifications/literature data, when possible Relevance and consequences of the present work for future research Financial/commercial interests, funding sources *Supervised statistical methods require output variables to be available and serve to estimate functions that best approximate the relationship between the input and output variables in the dataset (e. g. , linear regression). Unsupervised statistical methods are not provided with output variables but are concerned with uncovering structures within datasets without prior knowledge of how the data are organized (e.
RELATIONSHIP OF DEPRESSION WITH BLOOD PRESSURE AND PULSE RATE 1 JJ Burns, 2 R Amin*, 1 J Bruyere, 1 E Eloselly, 1 A Kurady, 1 S Khurana. 1 University of Florida, Pensacola, FL; 2 University of West Florida, Pensacola, FL 10. 1136/jim-2020-SRM. 52 Purpose of study The purpose of this study is to determine if there is a relationship between depression on blood pressure and pulse for adolescents over 13 years attending an Adolescent Medicine clinic. Methods used A database was created of adolescents diagnosed with a depressive disorder. A control group without depressive diagnosis was used for comparison. Outcomes were systolic and diastolic BP percentiles and pulse rates. A two-way type III ANOVA using transformed variables was used to analyze systolic and diastolic BP percentiles and pulse rates as dependent variables and sex (male/female) and depression status (depressed/non-depressed) entered as fixed factors.
Metronidazole was promptly discontinued, and the patient reported improvement in his symptoms two weeks later and resolution of MRI changes. Conclusions The progression of MIE is related to the persistent drug effect in the blood or brain. Our case is unique as simply stopping the offending agent helped reverse the patient's symptoms. Methylprednisone was not required. Purpose of study The aims of this study are to describe a national cohort of infants with necrotizing enterocolitis totalis (tNEC) and to identify unique tNEC risk factors when compared to non-totalis, surgical NEC (sNEC). Methods used Infants undergoing NEC surgery were identified from 34 hospitals over 6 years through the Children's Hospitals Neonatal Database (CHND). Those with isolated spontaneous intestinal perforation, intestinal anomalies, and major congenital anomalies were excluded.
Over the next 2 days, he developed abscesses in groin and axillae bilaterally, which were surgically drained. He was discharged on metronidazole, TMP/SMZ, and antiretroviral therapy. He was seen in dermatology clinic, diagnosed with HS, and prescribed isotretinoin. Over 9 months, his folliculitis improved significantly. Discussion A retrospective study of 2 large CDC databases examined 3. 45 million ambulatory visits for HS from 2002-15 and found a significant association with HIV (OR 6. 39), relative to smoking (OR 2. 65) and obesity (OR 2. 86). The virus activates the immune system via specific pro-inflammatory cytokines that also play a role in HS. The severity of facial involvement seen in our patient is unique, which may represent the rare diagnosis of acne conglobata (AC), a severe form of acne causing deep burrowing abscesses.
Abnormal CMA/karyotype results could guide counseling of the patient's family on long-term prognosis. Purpose of study There is incosistent evidence suggesting association of retinopathy of prematurity (ROP) and inhaled nitric oxide (iNO). We aimed to (i) To determine if there is an association between the use of iNO and ROP in very preterm infants (£32 weeks of gestation or £1500 gram birth weight) (ii) To determine factors predicting ROP in infants who had early exposure (before 32 weeks of corrected gestation) of iNO. Methods used We used the national multicenter Kids' Inpatient Database (KID) database during years of  2003, 2006, 2009, 2012, and 2016. Infants who died before 32 weeks of corrected gestational age and transferred out were excluded. Infants who had a procedure code of iNO use (ICD-9: 0010, ICD-10: 3E0F7SD) before 32 weeks of corrected gestational age were identified as iNO use.
OUTCOMES OF MULTIPLE GESTATION COMPARED TO SINGLETONS: ANALYSIS OF MULTICENTER KID DATABASE Case presentation A preterm, 1600 grams male neonate was born by spontaneous vaginal delivery to 24 years old, gravid 2 mother. Prenatal screening laboratory studies were unremarkable. Prenatal ultrasound findings included polyhydramnios and absent stomach bubble. Infant was intubated and given surfactant in the delivery room. Apgar scores were 1, 2 and 5 at 1, 5, and 10 minutes respectively. A Replogle catheter was inserted to 11 cm. Chest x-ray showed: right hemithorax with no lung aeration, mediastinal shift to the right and right atretic mainstem bronchus. Echocardiogram was significant for cardiac position severely displaced rightward and mildly hypoplastic right pulmonary artery, consistent with possible right lung hypoplasia.
Abstract 393 Figure  1   Purpose of study Neonates with necrotizing enterocolitis (NEC) may require intestinal resection with enterostomy and mucous fistula. They often require prolonged total parental nutrition (TPN) and are at risk for poor growth, cholestasis, and infection. A proposed nutritional strategy of mucous fistula refeeding (MFR) is accomplished by collecting enterostomy output and instilling contents into the MF. We evaluated the hypothesis that patients with surgical NEC who received MFR had improved clinical outcomes (growth, complications, resource utilization) when compared to patients without refeeds. Methods used This retrospective case-control review identified subjects from a single quaternary NICU through Children's Hospitals Neonatal Database (CHND). Study cohort included patients who underwent NEC surgery with resultant enterostomy and MF and survived to discharge.
Purpose of study To evaluate the true enhancement burden of tumors following immediate post-operative changes as well as following sequential MR imaging. Methods used HIPPA-compliant, IRB-approved retrospective post-hoc analysis of 17 patients with glioblastoma multiforme (GBM) treated with bevacizumab who reported to have a residual disease on MRI data acquired in 1 to 3-month interval. MRI series including T2-FLAIR, T1-W, and enhanced T1-W were assessed in initial post-op and follow-up series. MRI data were exported from PACs to DICOM viewer (MIM v6. 9). Next, an experienced neuroradiologist segmented the GBM tumors in FLAIR, unenhanced and enhanced T1-W MRI series. Subsequently, the segmented volumes were exported to MatLab where the pixel-by-pixel hyperintensities subtraction was performed in each volume slice using an inhouse algorithm obtaining a color map.
Total RNA was extracted using TRIzol method. miR cDNA and cDNA were generated and analyzed by real-time qPCR with specific primers. Western blot was performed using specific O-GlcNAc antibodies. Summary of results GlcN decreased the expression of miR-129 (0. 71-vs 1. 0-fold change control) and miR-181a (0. 68-vs 1. 0-fold change control) and increased the expression of miR-129  (1. 22-vs 1. 0-fold changed control). GlcN had no effect on the expression of miR-221 (1. 01-vs 1. 0-fold change control). TNFa had no effect on miR-129 level (1. 1-vs 1. 0-fold change. To further identify a possible role of miR-129 in GlcNAcylation, we used microRNA Target database to identify a miR-129 target gene. We found ICAM-1 gene a potential miR-129 target. TNFa induces ICAM-1 and reduces O-GlcNAcylation of proteins.
After pooled islets were obtained, RNA was extracted, and microarray used to assess transcriptomes. We used GeneSpring software (version 13. 0, Silicon Genetics, Redwood, CA) to generate a list of genes that showed differential expression between donors/VIMs. Using Webgestalt we identified pathways enriched in the lists of differentially expressed genes. Summary of results A total of 85 genes with a fold change of 1. 1 and p-value=0. 001 were differentially expressed between islets with 0 VIMs and islets with 1 VIMs. Pathway analysis showed strongest enrichment for the insulin secretion pathway (enrichment ratio of 6. 9 and a P-value of 5. 7E-7). Closer analysis of this gene list indicated decreased expression of genes involved in insulin secretion in islets with 1 or more VIMs. Two genes of particular interest, KCNJ11 and ABCC8, had significantly lower expression in the islets with 1VIMs compared to islets with 0 VIMs (p=0.
THE EFFICACY OF TELEHEALTH AS AN ALTERNATIVE TO FACE-TO-FACE VISITS FOR PEDIATRIC WEIGHT MANAGEMENT T Lukenbill*, A Simpson, J Carter, C SanGiovanni. Medical University of South Carolina, Mount Pleasant, SC 10. 1136/jim-2020-SRM. 473 Purpose of study Telehealth offers a means of expanding quality care to patients who cannot readily access the resources available at large medical centers. Research on the use of telehealth for pediatric weight management to date has primarily focused on feasibility and satisfaction, with little available data existing on efficacy. Methods used We examined data from subjects enrolled in a nutrition and lifestyle program for overweight and obese children 2 to 22 years old, during the time period of January 2017 to September 2019. Data was collected from a database that records patients' anthropometrics and lab work every six months.
Purpose of study Firearm-related injuries are the second leading cause of pediatric death in the US. Understanding the details of these injuries is vital to identify at-risk populations & tailor interventions. The aim of this study was to analyze trends of pediatric firearm injuries & deaths in a high-risk southern state and identify the populations at most risk. Methods used A chart review of firearm-related hospitalizations at the state's only freestanding children's hospital was conducted from 2000-2015. The Jefferson County Medical Examiner's office provided additional data to account for children who died prior to making it to a hospital setting. 28 variables were analyzed. Data analysis was conducted using the SAS frequency procedure. Summary of results 356 patients were enrolled in the study (n=254, 71% from hospital records & n=102, 29% from Medical Examiner's office).
Methods used Qualitative interviews were conducted by trained bilingual staff using structured interview guides to obtain mother's perspectives after their family completed the program. Mothers received weekly video surveys to complete that were analyzed using SPSS software. Summary of results A total of 26 mothers were interviewed. A majority of mothers enrolled their families in PSNS to improve father-child relationships. These mothers cited that PSNS helped fathers spend more time with their children which translated into improved child well-being, confidence, and communication skills. Mothers noted that PSNS improved their family's health knowledge, nutrition habits, screen media use, and physical activity behaviors. Mothers who joined the Facebook page had a positive experience and were able to see the program's real-time impact.
The extracellular lymph node stromal cell (LNSC) microenvironment may enhance tumorigenesis via extracellular vesicle (EV) mediated communication of miRNAs. Abnormal expression of miRNAs in human cancers is associated with enhanced tumorigenesis and metastatic potential. Methods used Total miRNA sequencing was performed on tonsil-derived stromal cells and their EVs, mesenteric LNSCs and their EVs, and 5 well-studied colorectal cancer (CRC) cell lines using Next Generation Sequencing. MicroRNAs overexpressed in LNSCs and their EVs compared to CRC cells were further analyzed using in silico computer prediction models (DIANA-miRPath v2. 0). MicroRNAs with higher expression in LNSC EVs than CRC cells were compared with known cancer specific pathways in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database and were selectively chosen for tumor cell migration assays.
Conclusions This study shows that most (60%) IG patients can normalize their GE after 1 year of treatment accompanied by improvement in symptoms. However, there is a disparity on the degree of symptom reduction and change in GE. Further research with larger numbers of IG patients and longer follow up will be necessary to address this finding. Purpose of study Literature suggests that an index admission with Hepatic Encephalopathy (HE) is associated with all-cause readmission in patients with cirrhosis. Recent literature proposes that urban and rural patients may have different morbidity and mortality. We determined the 30-day all-cause readmission rate and risk factors for adults admitted with a principal diagnosis of HE originating from a rural or urban location. Methods used We utilized AHRQ's 2014 Nationwide Readmission Database to identify admissions with a principal diagnosis of HE (ICD-9 572.
Methods used This study was a cross-sectional questionnairebased study of SCD patients at UT Physicians Comprehensive Sickle Cell Center, Houston Texas, from January 2012 to May 2018. We administered questionnaires during routine clinic visits and we reviewed clinical data in the electronic medical records. Descriptive analysis was performed with frequency distributions. Univariate logistic regression was conducted to investigate the association between recreational drug use and employment status. Summary of results A cohort of 60 SCD patients completed surveys about employment and recreational drug use. In the survey, only eight patients (13. 3%) reported using at least one recreational drug. However, after review of the electronic medical record for urine drug screens, twenty out of sixty (33.
It is important to note that only 3 out of 60 patients (5%) used multiple recreational drugs; hence, polysubstance abuse was rare in our SCD patients' sample. Purpose of study A key issue in FL is the identification of patients who will fail early. We recently reported (Am J Hematology 2019) that bone involvement on FDG-PET/CT predicts early clinical failure. In aggressive lymphomas, PET has replaced the routine need for a staging BMB. There is no such evidence in FL. The goal of this study was to determine the value of PET/CT in determining bone involvement in FL. Methods used We included 548 patients from the Mayo Clinic Lymphoma Database with newly diagnosed FL grades 1-3A between years 2003-2016, with available BMB results and PET/CT imaging at diagnosis. Bone and spleen involvement on PET/CT, bone SUV max and SUV mean at L3, and BMB results were recorded and compared.
Summary of results Using BMB as the gold standard, the sensitivity and specificity of PET/CT in detecting bone involvement were 60% and 80%, respectively. We noted that 59 patients had focal bone involvement on PET/CT rather than a diffuse component, and found that 47% of these patients had a negative BMB obtained in the posterior iliac crest. Excluding these patients, the sensitivity and specificity of PET/CT in detecting bone involvement were 53% and 88%, respectively. 29% of patients had evidence of splenic FL involvement on PET/CT. The sensitivity and specificity of spleen involvement on PET/ CT in predicting bone involvement by BMB were 55% and 86%, respectively. We recorded SUV data at L3 in the 439 patients who had either a diffuse pattern of bone involvement on PET/CT, or a negative scan.