dataesr/scientific-paragraphs-categorization huggingface dataset:
ACKNOWLEDGMENTS This project has received funding from the  Innovative Medicines Initiative 2 Joint Undertaking  under grant agreement No. 116020  ("ROADMAP"). This Joint Undertaking receives support from the  European Union 's  Horizon 2020 research and innovation program  and  EFPIA. It is also supported by the  Medical Research Council Dementias Platform UK  ( MR/L023784/1  and  MR/009076/1 ). The authors would like to acknowledge  Dr. Sue Chambers  and  Karen Goa  ( Rx Communications, Mold, UK ) for medical writing assistance with the preparation of this manuscript, funded by  Eli Lilly and Company. They would also like to acknowledge the ROADMAP contributors: University of Oxford, UK;  National Institute for Health and Care Excellence (NICE), UK ;  Erasmus Universitair Medisch Centrum Rotterdam , the  Netherlands ;  Universiteit Maastricht , the Netherlands; Synapse Research Management Partners SL, Spain;  Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Spain ;  Københavns Universitet, Denmark; Alzheimer Europe, Luxembourg; University of Edinburgh, UK; Goeteborgs Universitet, Sweden; Aarhus Universitet, Denmark ;  London School of Economics and Political Science, UK; Agentschap College ter Beoordeling van Geneesmiddelen/Medicines Evaluation Board , the  Netherlands ;  IXICO Technologies Ltd, UK ;  Rijksuniversiteit Groningen , the  Netherlands ;  Novartis Pharma AG, Switzerland ;  Eli Lilly and Company Ltd, UK ;  Biogen Idec Ltd, UK; F.
ACKNOWLEDGMENTS We thank the  Belgian Coordinated Collections of Microorganisms in the Institute of Tropical Medicine Antwerp  (http://bccm. belspo. be/about-us/bccm-itm)for the strains tested in this study; and  Siemon Gabriëls ,  Michèle Driesen ,  Wim Mulders ,  Jelle Keysers , and  Pauline Lempens  of the  Institute of Tropical Medicine Antwerp Mycobacteriology.
RNA-Seq library construction and sequencing RNA-Seq libraries were prepared using the Illumina TruSeq Stranded Total RNA library prep, after ribodepletion with the Epicenter Ribozero Gold kit (cat# RZE1224) starting from 500 ng of DNAse I treated total RNA, following the manufacturer's protocol, with the exception that 14 cycles of PCR were performed to amplify the libraries, to keep the duplication rate lower than with the recommended 15 cycles. The amplified libraries were purified using AMPure beads, quantified by Qubit and QPCR, and visualized in an Agilent Bioanalyzer. The libraries were pooled equimolarly, and loaded on an Illumina HiSeq 2500 flow cell, v4 chemistry as paired end 50. The R statistical software environment was used to run the Bioconductor package, DESeq2 to analyze the RNA-Seq data set for differential expression between groups (Applied Bioinformatics Laboratory, NYU School of Medicine, New York, USA).
Functional module extraction and functional enrichment The NetworkMiner  [18]  web-tool implemented in the Babelomics suite  [17]  was used to extract the relevant protein-protein interaction networks associated to each of the two conditions compared. The input for NetworkMiner was the list of genes identified in the RNASeq experiment ranked by the stat parameter of the DeSeq2 analysis. We used the "All ppis" interactome (genes version) and allowed one external intermediate protein. The FatiGO algorithm  [19]  was applied to perform the functional enrichment analysis of the proteins in each of the networks (excluding orphan nodes). We run FatiGO using GO terms (biological processes) as annotation and the interactome used for the NetworkMiner analysis as the reference list of genes. A value of p-value adjusted by FDR b0.
RNA extraction and real-time PCR Femoral tissues were snap frozen in N2 liquid and homogenates were resuspended for mRNA analysis. Total RNA from VSMC or femoral arteries was obtained by TRIzol method (Life Technologies) and quantified by absorbance at 260 nm in duplicate. 2μg of total RNA was reverse transcribed according to the manufacturer's protocol (Applied Biosystems). Real-time PCR was performed on a TaqMan ABI 7700 Sequence Detection System using specific TaqMan probe for 18S (VIC-TAMRA 431089E), Tnfrsf12a (Mm_00489103_m1) and Tnfsf12 (Mm 02583406_s1) or SYBR Green (Takara Biotechnology) depend of the studied gene. PCR primers for SYBR Green are available in the data supplemental (Supp. Table  1 ). 18S rRNA served as housekeeping gene for TaqMan studies and Gapdh for SYBR. Housekeeping genes were amplified in parallel with the genes of interest.
Immunohistochemistry color was developed with DAB (Dako), and section were counterstained with hematoxylin, and mounted in DPX (Millipore). Incubation without primary antibodies and/or irrelevant species and isotype-matched immunoglobulins was performed as a negative control for all immunostaining studies. Computer-assisted morphometric analysis was performed with the Image-Pro Plus software (version 4. 5. 0 for Windows) in a blinder manner. The threshold setting for area measurement was equal for all images. Results were expressed as % positive area of, Cyclin D1, CDK4, CDK6 and, p15 INK4B in total artery, and as % of PCNA positive cells versus total cells. For human tissues, primary antibodies were anti-α-SMA (1:500; ab5694 Abcam), anti-calponin (1:100; ab46794 Abcam), anti-TWEAK (1:100; ab37170 Abcam), anti-Fn14 (1:50; ab109365 Abcam) and anti-PCNA (1:200; sc-7907, Santa Cruz Biotechnology).
Statistical analysis Animal sample size for each study was chosen based on literature documentation of similar well-characterized experiments. The number of animals in each study is listed in the figure legends. Values are expressed as mean ± SEM (n is noted in the figure legends). In vitro experiments were replicated at least 3 times unless otherwise noted. Statistical differences were measured using two-sided Student's test or a one-way ANOVA followed by a post hoc Bonferroni pairwise comparison test. A nonparametric test (Mann-Whitney) was used when data did not pass the normality test. A value of p b. 05 was considered statistically significant. Data analysis was performed using GraphPad Prism Software Version 7 (GraphPad, San Diego, CA, USA).
File 1). We performed a gene set-like network enrichment analysis using NetworMiner algorithm in order to capture the most relevant functional modules, that are up/down regulated by rTWEAK in VSMCs  [18]. This method extracts functional modules associated to a phenotype by evaluating both, the topological robustness of a protein-protein interaction network and the link of its components to a condition. The modules are presented as protein networks and the level of significance is obtained from a comparison to networks generated from random lists of genes. Remarkably, the resultant network may contain proteins not necessarily labeled as associated to the phenotype by the expression analysis but important in the internal structure of the functional module. We obtained two significant protein networks linked to genes up and down-regulated by TWEAK.
Acknowledgments We thank to  Dr. Linda Burkly  ( Biogen, Inc. Boston, MA, USA ) for contributing to the conception and design of the study,  Dr. Carmen Gómez-Guerrero  ( IIS-FJD, Madrid, Spain ) for critical suggestions,  Dr. Jose Martínez-Gonzalez  ( IIBB-CSIC Sant Pau, Barcelona, Spain ) for providing healthy human coronary arteries and  Patricia Quesada  ( IIS-FJD, Madrid, Spain ) for her technical assistance.
Study subjects and sampling Researchers targeted a non-probability sample of adolescent girls under the age of 20 years (married n = 21, unmarried n = 20) as well as husbands of adolescent girls (n = 21), influential adults (n = 15), community leaders (n = 15), health providers, (n = 13), and positive deviants (married adolescents who purposefully delayed birth for at least 2 years, n = 2). Both married and unmarried girls were included to understand the continuum of support needed for young adolescents as they transition from their natal homes into life as a married woman. Health providers included both physicians, nurses and midwives based at facilities as well as community health workers operating within target villages. Within each district, local data collectors, trained by CARE staff, asked community leaders to assist them in identifying married and unmarried adolescents for participation in interviews.
Data collection and storage Interviewers from the local population who were fluent in the local language were selected to minimize bias and increase comfort among participants. Female and male participants were also matched to interviewers of the corresponding gender. All interviews were held in a private area within the village and audio-recorded with the consent of participants, and each participant was interviewed individually. Each interview involved two data collectors: one conducting the interview using a pre-tested semi-structured interview guide, and one taking notes. At the end of each data collection day, recordings and notes were collated by the research team leader and transported to the CARE Niger office for storage in a locked cabinet. Only relevant members of the research team and program staff had access to these materials throughout the course of the study.
Acknowledgements The authors would like to thank the staff of CARE Niger, namely  Aboubacar Nouroudine ,  Saratou Malam Goni & Fourera Abdoulaye  for supporting the development of data collection tools and organizing data collection. We would also like to thank  Afric' Act  and in particular  Dr. Ousseini Abdoulaye  in supporting data collection and analysis. This study was made possible through the generous support of  The Bill and Melinda Gates Foundation.
Statistical analysis Data were analysed with STATISTICA 13. 1 software. The normality of data was tested by Shapiro-Wilk test. Mean values of SDI and ADI were evaluated for each IIM subtype and compared between groups with Kruskal-Wallis ANOVA on ranks with post hoc tests. Number and percentage of responders who needed to use each type of facilitating devices were compared with χ 2 Test. Kruskal-Wallis statistic with post hoc Dunn's Multiple Comparison Test was used to compare intensity of myalgia, feeling of muscle weakness as well as tolerance of physical activity and degree of fatigue between groups of patients with different IIM subtype. Relation between disease duration and mean values of SDI and ADI was assessed with ANOVA Kruskal-Wallis on ranks with post hoc analysis. To evaluate the influence of myalgia, feeling of muscle weakness, tolerance of physical activity and fatigue on SDI and ADI scores linear regression was performed.
Photophysical characterization of DEAC-based fluorophores The photophysical properties of synthesized 7-(diethylamino)coumarins 7-10 were evaluated in DMSO (solvent in which these compounds are perfectly soluble and used for the preparation of their stock solutions), in EtOH and in phosphatebuffered saline (PBS, pH 7. 5) which mimics physiological conditions. Fluorophores 7-10 were found to be perfectly soluble in PBS only at low concentrations (less than 5 µM). At higher concentrations, light scattering by suspension was clearly observed on UV-vis absorption spectra (Fig. 3C  and Figs. S21, S22, S32, S33, S36 and S39). All results are compiled in Table  1  (see Fig. 3  for the absorption/fluorescence spectra of 8 and Supplementary data for the absorption/fluorescence spectra of compounds 7, 9 and 10).
Acknowledgments This work is supported by the  CNRS ,  Université de Bourgogne  and  Conseil Régional de Bourgogne  through the  "Plan d'Actions Régional pour l'Innovation (PARI)  and the  "Fonds Européen de Développement Régional (FEDER) " programs. B. R. gratefully acknowledges the " Région-Haute Normandie " for his Ph. D. grant (2012Ph. D. grant ( -2015)). Financial support from  Agence Nationale de la Recherche  ( ANR ,  AAPG 2018 ,  DetectOP_BChE ,  ANR-18-CE39-0014 ), especially for the post-doc fellowship of V. Q. is also greatly acknowledged, as well as  Labex SynOrg  ( ANR-11-LABX-0029 ). The authors thank the  "Plateforme d'Analyse Chimique et de Synthe se Mole ćulaire de l'Universite ́ de Bourgogne" (PACSMUB , http://www. wpcm. fr)for access to spectroscopy instrumentation and  Iris Biotech  company for the generous gift of some chemical reagents used in this work.
Curcumin extraction and dosage First, it was found in preliminary studies (data not shown) that ethanol is the best solvent for curcumin extraction; moreover, it is readily available and less dangerous than other organic solvents. A wavelength of 425 nm was chosen for performing curcumin quantification by UV-visible spectrophotometry. Curcumin extraction was achieved according to the following procedure: 0. 1 g curcumin-loaded skim milk powder was solubilized in 5 mL distilled water using a Stuart SB3 rotator for 50 min at 40 rpm at 25 ± 1 °C. Then, 10 mL diethyl ether was added, and the mixture was allowed to stir in the same conditions. The mixture was then centrifuged at 5 088 x g for 5 min with a Hereaus Megafuge 8R centrifuge (Thermo Fisher Scientific) and the supernatant was recovered and placed under a dinitrogen atmosphere until complete evaporation of diethyl ether.
Acknowledgements The authors wish to thank  Payot Laurent ,  Delaunay Regis ,  Moukda Khounlaboud  ( Yves Le Foll General Hospital ). Slide sets: A fully edited slide set detailing this case and suitable for local presentation is available online as Supplementary data. Consent: The author/s confirm that written consent for submission and publication of this case report including image(s) and associated text has been obtained from the patient in line with COPE guidance.
CR was analyzed using the same methods as for the analysis of ORR. The safety population (defined as all subjects who received at least one dose of study treatment) was used for the safety analyses, including AEs, concomitant medication, laboratory tests, vital signs, ADA, and NAb incidence and titers. The serum concentration-time data were summarized using descriptive statistics by treatment (PK population). PD biomarkers were summarized by treatment and study visit (modified ITT population).
Furthermore, at week 26 (based on updates to the central review assessment as of the final database lock on May 18, 2018), 51 out of 174 subjects (29. 3%) versus 57 out of 184 subjects (31. 0%) had CR in the PF-05280586 and rituximab-EU groups, respectively, and 97 out of 174 subjects (55. 7%) in the PF-05280586 group and 83 out of 184 subjects (45. 1%) in the rituximab-EU group had PR. A total of 20 out of 174 subjects (11. 5%) versus 36 out of 184 subjects (19. 6%) had stable disease in the PF-05280586 and rituximab-EU groups, respectively, and six out of 174 subjects (3. 4%) and eight out of 184 subjects (4. 3%) had progressive disease (PF-05280586 vs rituximab-EU, respectively) (Online Resource 4, see the ESM).
e. , development for all indications has been discontinued). Pfizer will also consider requests for the protocol, data dictionary, and statistical analysis plan. Data may be requested from Pfizer trials 24 months after study completion. The de-identified participant data will be made available to researchers whose proposals meet the research criteria and other conditions, and for which an exception does not apply, via a secure portal. To gain access, data requestors must enter into a data access agreement with Pfizer. Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4. 0 International License (http://creat iveco mmons. org/licen ses/by-nc/4. 0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Overall response rate at week 26 a (central review assessment) CI confidence interval, CR complete response, ITT intent-to-treat, PP per-protocol, PR partial response, rituximab-EU rituximab reference product from the European Union a Based on the central review assessments as of the final database lock on May 18, 2018 b Subjects missing their week 26 radiology assessments were imputed as nonresponders c Defined as the percentage of subjects achieving CR or PR, based on central review.
Acknowledgements. We thank  C. Bartoli ,  J. -D. Förster ,  T. Godwill ,  N. -M. Kropf , and  E. Stopelli  for technical assistance,  G. D. Franc ,  T. C. J. Hill ,  B. Sánchez-Parra ,  J. F. Scheel , and  M. G. Weller  for helpful discussions, and the  Max Planck Society (MPG) , the  Deutsche Forschungsgemeinschaft (DFG ,  FR3641/1-2 ,  FOR 1525 INUIT)  for financial support. This work is dedicated to the memory of Gary D. Franc, whose pioneering work in atmospheric microbiology has been an inspiration for this work.
Transmission electron microscopy (TEM) images were recorded on a Microscope Fei Tecnai 10 operating at an accelerating voltage of 80 kV (Oregon, USA). For USPIO samples, a drop of diluted suspension ([Fe] ≈ 0. 5 mM) in THF was placed on a carbon-coated copper grid (300 mesh). Images were analysed using automated particle counting of ImageJ software after thresholding and watershed filtering, enabling to perform a statistical treatment of the diameters. Based on a minimum of 1000 nanoparticles per batch, the polydispersity index (PDI TEM ) was calculated using the following equations, by analogy with dispersity (Ð) defined for polymer chains, but subtracting 1 to obtain a PDI below 1 (like in DLS): For empty vesicles (pure PEO-b-PCL nanoprecipitated copolymer), negatively stained TEM images were acquired by placing successively a drop of diluted suspension (2 minutes), a drop of phosphate-buffered saline (pH 7.
Journal of Materials Chemistry B Please do not adjust margins STE-LED (stimulated echo-longitudinal eddy current delay) standard sequence with a diffusion time (Δ) of 250 ms, a gradient pulse length (δ) of 1 ms and 16 gradients ranging from 2% to 95% of the maximum gradient (53 G/cm). Nuclear magnetic relaxation dispersion (NMRD) profiles reporting the longitudinal relaxation rates of water protons (R 1 ) over a magnetic field range from 0. 25 mT to 0. 94 T (0. 015 -40 MHz proton resonance frequency) were recorded on a Fast Field Cycling (FFC) relaxometer (Stelar, Mede, Italy). The apparent saturation magnetization (M S NMRD ), the Néel relaxation time (τ N ) and size of superparamagnetic crystal (D NMRD ) were determined by fitting these NMRD curves numerically with the MINUIT minimisation program within the frame of the Outer Sphere relaxation model and a standard phenomenological approximation  [40].
SANS curves were fitted with the vesicle (shell) form factor thanks to SASView software. The values obtained from the fitting are R in = 84 nm and d = 17 nm, where R in corresponds to the inner aqueous compartment radius and d to the membrane thickness (the radius of the vesicle R tot , is given by: R tot = R in + d). One can note that radii and thickness values calculated by fitting the SANS curves exhibit broad dispersity parameters  (no unit),e as samples analysed by SANS were not extruded to avoid sample loss on the filters as SANS analysis requires concentrated enough samples, in this case 6. 2 mgmL -1 ). The I(q) curves computed using a hollow spherical shell model are well superimposed on experimental data, supporting the assumption that nano-vesicles are formed through the self-assembly of PEO 45 -b-PCL 111 copolymers (Fig.
Acknowledgements The authors thank the department of histology ( Prof. D. Nonclercq ) of the  University of Mons  and  X. Valentini  for providing the access to TEM apparatus. Dr. L. Mespouille  (SMPC; UMons) and  Dr. J de Winter  (S2Mos; UMons) are warmly acknowledged for providing the polymers used during this study. The authors are grateful to  Prof. O. Ersen  and  D. Ihiawakrim  from  "Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS) " from the  University of Strasbourg  from cryo-TEM analysis and  Amélie Vax-Weber  and  C. Pierart  for performing respectively the GPC and ICP measurements. The authors acknowledge the  Center for Microscopy and Molecular Imaging (CMMI). This work was performed with the financial support of the  FNRS , the  Agence Nationale de la Recherche  ( ANR-13-BS08-0017  MagnetoChemoBlast), the  ARC program , the  ENCITE program  and the  RW , the  Interuniversity Attraction Poles of the Belgian Federal Science Policy Office , and the  European Commission  under  COST (European Cooperation in Science and Technology) Action TD1402 RadioMag.
Introduction The quality of electromyography (EMG) recordings and the validity of the interpretation of the data depend on many characteristics of the recording set-up and analysis procedures. The optimal features differ between applications based on the question to be addressed and the muscle under investigation. There are many issues to consider and the purpose of the Consensus for Experimental Design in Electromyography (CEDE) project is to provide expert consensus opinion of optimal features of recording set-up and analysis to address a range of experimental questions. EMG electrodes are the interface between the tissues and the recording system. The properties of the signal depend on their type (surface or intramuscular), configuration (e. g. bipolar, matrix), and materials/construction (e.
Changes or new information proposed by contributors were highlighted in the second-round questionnaire. The same process was followed for subsequent rounds. All contributors reviewed the final document for endorsement and were included as authors. For this matrix, 20 experts participated in the Delphi process. The lead investigator (PH) and the coordinator (MB) did not participate in that process, but in addition to developing the initial content, they oversaw the project and collected/ integrated all the responses. All data were entered into Microsoft Excel and processed using the statistical package STATA/IC (version 14). The number and percentage of participants rating each outcome as appropriate (score 7-9), uncertain (score 4-6) and inappropriate (score 1-3) were calculated, as well as the median and IQR for each item.
2 Physiological: Detection of temporal events of EMG". Content was developed by the steering committee and two additional CEDE project team members. A single round Delphi process was used to seek comment and approval for the content (included in Appendix 1). Comments from team members were integrated and approval granted. The final electrode selection matrix is presented in Table  2. Additionally, a checklist (Table  3 ) is provided to guide and facilitate the reporting of EMG data based on the content of the matrix.
Funding This research was funded by the  National Health and Medical Research Council (NHMRC) of Australia  (Program Grant:  APP1091302 ),  Australia. PWH is supported by an  NHMRC   Senior Principal Research Fellowship  ( APP1102905 ),  Australia. MB is supported by the  University of Queensland Research Training Scholarship, Australia. MCK was supported by a  Program Grant  ( APP1132524 ), Partnership Project ( APP1153439 )  and Practitioner Fellowship (APP1156093)  from the  NHMRC, Australia. AH is supported by  Slovenian Research Agency  (projects  J2-7357  and  L7-9421  and Programme funding  P2-0041 ), Slovenia.