dataesr/scientific-paragraphs-categorization huggingface dataset:
Patients This retrospective and monocentric study included all children who underwent HSCT to treat CEP between 1994 and 2016 in the Pediatric Immuno-Hematology and Rheumatology Unit of Necker-Enfants Malades Hospital, Paris, France. Clinical, biological, histological, and radiologic data were collected until September 2018. Before transplantation, all parents gave informed consent for anonymous use of the clinical and biological data for research purposes. This consent was renewed when the patients became young adults, according to the French regulations on clinical research.
Post-HSCT A biopsy was performed for the child experiencing his first episode of ALF (patient 4); the histological picture excluded GVHD, veno-occlusive disease, and acute viral hepatitis (no necrosis, no apoptosis, and microvesicular steatosis not exceeding 5% in the centrilobular zone). Lobular fibrosis was graded 1 to 3. The major findings were portal fibrosis (F2) with mild lymphocytic infiltrate, severe disarray of lobular architecture with centrilobular fibrosis and perisinusoidal fibrosis (grade 3), moderate hepatocyte ballooning (30%), and numerous ground glass-like inclusions (20%), associated with mild porphyrin deposition in hepatocytes (Figure  2 ). Two biopsies were performed for the child with severe GVHD (patient 6). Histopathology confirmed the diagnosis (data not shown).
In addition to the severity of the disease, the place of HSCT will have to be evaluated in the light of donor characteristics (HLA-identical sibling or unrelated haploidentical donor) and alternative treatment, such as induced iron deficiency or future gene therapy. In all cases, it will be based on a careful case-by-case evaluation and a very close collaboration between a porphyria specialist and the HSCT team. In conclusion, we strongly suggest that the initial workup before HSCT includes a liver biopsy to evaluate the level of liver damage and the level of porphyrin accumulation. Despite HSCT-related morbidity and mortality, long-term data support the use of HSCT as a life-changing treatment for patients presenting an early and severe form of CEP.
The aim of Beacon is to develop the understanding of fundamental processes that lead to material homogenisation, as well as to improve capabilities for numerical modelling. In earlier assessments of bentonite EBS, the mechanical interaction between the installed bentonite components has been neglected and an "ideal" final state has generally been assumed. Key features of the project are (1) re-evaluation of the available knowledge to extract the crucial data to compile the qualitative and quantitative data and to enhance the conceptual understanding. (2) Enhanced, robust and practical numerical tools based on a good scientific understanding, which have the expected predictive capabilities regarding the evolution of engineered barriers and seals. (3) A developed database with experimental data needed by the quantitative models.
In WP2 the existing knowledge base is treated. The key objective of WP2 is the sharing of knowledge and experience. The partners have distributes information and results from earlier assessments, design considerations, experiments and modelling tasks. A strong driver for a joint project is the current limitations in the predictive capability in the numerical models. The issue of homogenisation and swelling is challenging both from a conceptual and a numerical point of view. The purpose of WP3 is to identify and resolve the shortcomings of current models. Although there is a substantial experimental database available for the project, it is necessary to perform additional experiments to support the model development in WP3 and the model testing in WP5. The experimental work is coordinated in WP4.
WP2 collection and compilation of existing data and available models The most important outcome of WP2 so far has been a report that documents the information that has been made available to the Beacon project by the project partners and associated organisations. The information relates to experiments at a number of different scales as well as modelling studies that have been undertaken. The report utilizes information provided by Beacon partners regarding experiments that have been carried out in earlier projects, with the purpose to build a database of experiments which can be used during the Beacon project and even beyond. The report documents the available data but does have the purpose to propose any experiments for consideration within the Beacon project. This objective will be handled by the Work Package leaders, based on the information contained in the report.
The report provides clear referencing to the underlying reports which contain further information, to facilitate the process of selecting datasets for modelling within Beacon. The process for collecting and compiling information into the database involved: creating a designated data form to collect appropriate information; requesting that Beacon partners and associated organisations fill out the form for any studies that could be relevant to Beacon; collation of the completed data forms into a database; arranging a workshop for the discussion of the database and definition of additional fields that would aid selection of experiments for modelling cases within Beacon; request for additional information to complete the new fields in database; completion of the database. The data forms entered into the database have been divided in three categories: laboratory experiments, mock-up experiments and in situ experiments.
The laboratory experiments include both experiments with the purpose to measure material properties, as well as experiments that simulate repository conditions in a smaller scale. There are many experiments listed in the database, at a range of scales (from bench top laboratory experiments to full scale field experiments), a small number of these were designed specifically for studies of bentonite homogenisation, but the majority were originally designed for other purposes. Nevertheless, all these experiments provide a valuable source of information on the mechanical properties of bentonite and the mechanical evolution of a bentonite barrier within a repository. The database contains information on the type of bentonite considered in the tests, the boundary conditions and initial and final heterogeneities within the experiments, but also the range of measurements taken in the experiment.
Stage 2: Literature search The following electronic databases were searched by the first author in December 2018 for English language publications: Science Direct, Web of Science, PubMed, PsychInfo and Scopus. The search therefore captures all research prior to the implementation of the Specialist Perinatal Mental Health  Model of Care (2017). The search terms were informed by keywords used in international publications on perinatal mental health:  (Perinatal OR antenatal OR pregnancy OR childbirth OR postpartum OR postnatal OR maternal) [in title, abstract, keywords]  AND  ("mental health") [in title, abstract, keywords]  AND  Ireland OR Irish [in all]  Stage 3: Study selection The data base searches led to 1738 results. The findings were exported to Endnote and to the online literature review programme Rayyan.
and could have been collected there. Cook (1777)  himself mentioned for Botany Isle the observation of "the Etos tree of Otaheite', which represents Casuarina (acc. Beaglehole 1961, as "Etoo"). Most of the Forsters' specimens seem to come from Tahiti (as Otaheite, Otaheiti, Taheitee or Taiti) and/or other Pacific islands (as Insulis oceani Pacificis, Insulae maris Pacifici intra tropicos Vol 39 or Insulae maris austr. intra tropicos). G. Forster's artwork (pl. 254; NHM-UK-L-5623-357-M-1!) is labelled in the BM database as from New Caledonia in September 1774, though 'Taheitee' is written on the sheet. Cynanchum viminale subsp. brunonianum (Wight & Arn. ) Meve & Liede (Apocynaceae). According to Nicolson and Fosberg (2004; as Cynanchum viminale), no specimen has been located anywhere. However, we found a specimen at BM (BM001252105!) from Cook's second voyage collected in New Caledonia without further location detail.
crassifolium and three branches of M. laetum. Other specimens of the Forsters and Sparrman from New Zealand, South Sea Islands or without locality are available in C, G, K and S (Nicolson & Fosberg 2004). Chinnock (2007) put the name M. pubescens under synonymy of M. laetum and designated as the lectotype the Forster specimen (UPS V-125556) labelled as Botany Island (fide Nicolson & Fosberg 2004) or Botany Bay (fide Chinnock 2007; Sweden's Virtual Herbarium Database, 2020). The last name, M. tenuifolium, was also lectotypified by Chinnock (2007) on a Forster specimen in BM (BM001040912!) from New Caledonia. Other specimens of Anderson, the Forsters and Sparrman are stored under this name and usually labelled as from New Caledonia and sometimes from New Zealand and South Sea Islands (Nicolson & Fosberg 2004).
Acknowledgements The authors are most thankful to the  South Province authority Direction de |'Environnement  for organising the fieldtrip to Améré, Kié and Nouaré islets on its two boats, and for providing a special permit (n°95-2019/ ARR/DENV) to visit the  Yves Merlet Integral Natural Reserve. Warm regards are extended to the  South Province rangers (Gardes Nature ), namely  Caroline Groseil  ( Head of Gardes Nature ),  Catherine Geoffray  ( Captain of Améré ),  Mickaél Le Corre  ( Captain of Noddi ),  Emilien Herlem ,  Pétélo Initia ,  Patrice Plichon  and  Sophie Raillard  who were helpful during the inventory. The research team from  IRD , composed of  Hervé Jourdan  (entomologist) and  Matthias Deuss  (herpetologist), who accompanied us to survey these poorly known islands from their perspectives are also thanked.
Pisier 1974)reported seeing or possibly collecting about 30 species on Botany Isle. He also reported that an officer who collected and ate a fresh salad of Tetragonia L. was made sick, probably because he mixed it with some Euphorbia or other plants. Since Tetragonia tetragonoides actually grows together with two Euphorbia species (Euphorbia obliqua Endl. andE. tannensisBiehler, see Table1) on flot Améré, Sparrman was probably right. The botany of Botany Isle from Cook's second voyage specimens Our intention is to review what is available from herbarium JSTOR Global databases, Plants and specimens mentioned and discussed by previous specialists of Pacific botany and history in orderto make a comparison with our 2019 inventory and to cross-check the information retrieved from the literature.
Acknowledgements The authors would like to thank the  Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)  and  Universidade Federal de Alfenas  ( UNIFAL-MG) for scientific initiation scholarship of V. Veroneze-Júnior. The authors also thank the  Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)  and  FAPEMIG  for the financial support to the research project ( APQ-00651-14 ); and the  Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)  for the post-doctoral researcher PNPD-institutional scholarship of  K. R. D. Souza  (Funding Code  001 ).
Last, we can perform the directed counterparts of the nodes transitivity-based strategies adopted here by using the 'directed nodes transitivity measure' , also known as clustering coefficient in directed networks  34. Differently, Weak and Strong strategies that rank the links in increasing and decreasing order of weight have not a 'directed counterpart' , since the links cannot be classified as ingoing or outgoing a node (e. g. a link outgoing a node is clearly ingoing to another). Last, the directed counterpart of the Rand strategy is meaningless, since the link order is a simple random sorting. the real-world complex networks data set. We test the efficiency of the link removal strategies using six well know real-world complex weighted networks. First, we selected this database because it is composed by the real-world weighted networks well known in literature and they are used in yet classic analyses.
Acknowledgements Many thanks to two anonymous reviewers which suggestions greatly improved the first version of the manuscript. This research benefits from the  HPC (High Performance Computing)  facility of the  University of Parma, Italy. MB and FS acknowledges financial support from  Fondazione Cariplo , grant n°  2018-0979. This project has received funding from the  European Research Council (ERC)  under the European Union's  Horizon 2020 research and innovation programme  (grant agreement No. [816313]). MB and FS thank  Prof. Emanuele Severino  for its eternal guidance.
Fungal Strains and Culture Conditions The marine-derived fungal strain T. albobiverticillius (collection number 30548, GenBank accession number MK937814) was isolated from the back reef-flat of Réunion Island  [35]. The three other strains used in this study were isolated from terrestrial environments, including T. harzianum (commercial biological control strain T22), E. purpurea (collection reference LCP 3323) and P. marquandii (collection reference LCP 2271) and were bought from the fungal culture collection of the Muséum national d'Histoire naturelle (MNHN, Paris, France). For submerged cultures, potato dextrose broth (PDB; Sigma Aldrich, Saint Louis, MO, USA) was used routinely as culture medium. The pH of the culture medium was adjusted to 6. 0 ± 0. 2 using 0. 1 M HCl prior to sterilization.
The yellow polyketide-based secondary metabolites produced by In parallel, the repartition coefficient for yellow pigments remained drastically smaller than repartition coefficient for red, K red, across all ATPSs as well as amongst all fungal strain productions. Even the bright-yellow-pigment-producing fungal strain, namely P. marquandii, did not generate partition coefficient values as high as red-pigment-producing fungal strains (i. e. , T. albobiverticillius and E. purpurea) for red to orange pigments. Such limited results for yellow compounds could be explained by the fact that reddish and orangish pigment-producing fungal strains may simply not produce many actual yellow molecules. In the case of the strong yellow-producing strain of P. marquandii, although the pigments clearly migrated to the ionic liquid-rich phase, the raw data of absorbance measured at 400 nm (yellow typical wavelength) were globally four times weaker in reddish strains, suggesting a smaller inherent yellow-pigment-production compared to red.
STUDY DESIGN AND OBJECTIVES We conducted a multicentric observational cohort study including adult patients who presented with suspicion of PS or TX hypersensitivity, from July 2012 to July 2018. ST and desensitization were conducted in the Allergy Department at the Nice University Hospital. Graded challenges (GC) were performed in two separate oncology centers in Nice (the Antoine Lacassagne anti-cancer center and the Oncology unit at the Nice University Hospital Center). All the patients who received an allergy evaluation gave their informed consent for clinical data collection and GC. The main objective of this study was to evaluate the NPV of ST for the diagnosis of hypersensitivity to PS or TX. Secondary objectives were to assess the feasibility of delegating GC to two different oncology teams, to analyze the characteristics of hypersensitivities to PS or TX and to identify patient phenotypes.
STATISTICAL ANALYSES: Data are presented as n (%) for categorical variables and as mean ± SD for continuous variables. The NPV of immediate reading of ST for PS or TX was defined as the proportion of non-allergic patients (i. e. patients tolerating chemotherapy drug reintroduction), among the patients with negative immediate reading ST. The NPV was calculated for each chemotherapy drug and each chemotherapeutic drug class. Comparisons were made for categorical variables by using nonparametric tests. A P value of less than. 05 was considered significant.
e. seawater fixation, preservation and expedition to a scientific laboratory). Once a sample arrived in a relay structure, it was then picked up and analyzed by the nearest laboratory to the water discoloration event (there are 6 dotted around Brittany's 2730 km of coastline). The species responsible for the bloom was identified through light microscopy by a taxonomist of the Phenomer consortium. When samples were not collected, the species responsible for the water discoloration was inferred either from data of the REPHY monitoring program or from data of ongoing scientific research projects in areas near the water discoloration event. Feedback was both spread to the scientific community for further research and to the general public on the website, via social media and newsletters (Fig. 1 ).
Analysis of water discoloration perception by citizens During 2013-2014, a series of 13 preliminary semi-structured phone interviews were carried out with those observers having accepted to be interviewed. The preliminary results from these interviews made it possible to outline a typical profile of the people taking part in Phenomer and to construct an ad-hoc questionnaire adapted to this population (Supp. materiel 1). Composed of a dozen questions, the questionnaire cross-examines the context in which the observation is made, what observers feel in relation to these phenomena and whether, according to them, HABs are likely to impact human health and/or the environment in either a good or a bad way. This questionnaire was then taken by water discoloration observers in 2015. All participants were informed of the data protection legislation protecting their personal data rights, in compliance with the CNIL (Commission Nationale de l′Informatique et des Libertés)  [10] , the French committee responsible for ensuring that information technology complies with national data protection legislation.
Participants submitting a phytoplankton bloom observation via the online form or Smartphone application are asked to tick a box certifying they have read and understood the "charte d′utilisation" (terms of use), which serves as a statement of informed consent, explaining their rights regarding personal data. When participants reported their bloom observations over the phone, they were informed of their personal data rights over the phone, and a log was kept of the conversation. All participant consent is recorded in the back office of the Phenomer website (ww. phenomer. org) where a database kept track of every phone call and completed form. The CNIL approved the type of data collected on participants, and manner in which collecting participant consent is recorded (ref. number 1684966 v0).
2014 observations yielded new information on the areas which could be potentially affected by these phenomena, both to the north and to the south of the Loire River output and the Vilaine Bay (Fig. 3B ). Data collected in the frame of Phenomer suggest L. chlorophorum blooms can be long lasting across southern Brittany waters. Continuous data (almost daily citizen alerts, 24 observations in total) over a period of almost one month suggest that blooms of this species can last at least one month and that a higher intensity of L. chlorophorum blooms can coincide with a fish mortality presumably caused by anoxic conditions. Interestingly, L. chlorophorum was considered as not being ingested by the oyster Magallana gigas, after in-situ observations carried out in the Bay of Vilaine, which suggest a potential negative effect on oyster growth during bloom concentrations  [1].
Acknowledgments The authors gratefully acknowledge all Phenomer participants (citizens and scientists) who shared discoloration observations and provided data and pictures of the phytoplankton blooms. The communication service of Ifremer/Nantes, and in particular  Sophie Pilven , is greatly acknowledged for its support for all communication actions and information dissemination of the project. The authors kindly thank  Elisabeth Nézan  and  Nicolas Chomérat  ( Ifremer LER/BO Concarneau ) for their help in the identification of the species toxic for marine fauna in occasion of the brown discolorations and for providing pictures of N. scintillans and L. chlorophorum (Fig. 3). The authors also thank  Beatriz Beker ,  Charlotte Soler  (LEMAR) and  Pascale Malestroit  (Ifremer) for their identification of microalgal species.
Acknowledgments Dr. Guoliang Li  has worked with  Guy H. Fontaine 's group in Paris since 2015 and was supported by the  Clinical Research Award of the First Affiliated Hospital of Xi 'an  Jiaotong University, China  (No. XJTU1AF-CRF-2015-007 ). The Zurich ARVC Program is supported by grants from the  Bertha and Georg Schwyzer-Winiker Foundation ,  Baugarten Foundation , both in Zurich, Switzerland and the  Swiss National Science Foundation. We dedicate this work to our great mentor and teacher  Guy H. Fontaine  who is deeply missed.
GRAMRVAC and general relativistic hydrodynamical simulations The GRAMRVAC code solves general relativistic hydrodynamics equations, including conservation of mass and momentum. Such equations are expressed while taking into account spacetime geometry around a rotating, uncharged black hole thanks to the Kerr metric  (Kerr 1963). Therefore, the general expression of any line element ds in a (3+1) splitting in Boyer-Lindquist coordinates is: ds 2 = -α 2 (cdt) 2 + γ i j (dx i + β i cdt)(dx j + β j cdt), ( 1 ) where α is the lapse function, β i is the shift vector and γ i j is the spatial metric tensor (see e. g. Casse & Varniere 2018 , for a definition of these quantities that involve the dimensionless spin parameter -1 ≤ a = Jc/GM ≤ 1, where J and M are the angular momentum and mass of the black hole, respectively).
Observational data are from  Sobczak et al. (2000)  for the spectral component and  Remillard et al. (2002)  for the timing component. In order to set our results in context, we use the data from XTE J1550-564, focussing on the most common case where only type C LFQPO are observed with no HFQPOs detected 3. The left of Fig. 10  shows how the fitted inner edge of the disc, with the actual inner edge remaining at the last stable orbit in the simulation, and its fitted temperature correlates when the amplitude of the RWI increases. For comparison, the black line represent a fit of data from XTE J1550-564 in the case of a type C LFQPO with no HFQPO. Our simulations shows a clear departure from the case where type C LFQPOs, with no HFQPOs, are observed. We went a step further and checked how that correlation obtained for a disc with an active RWI compared with observations of systems with detected HFQPOs.
Acknowledgements. We thanks the referee for his careful reading of the manuscript. PV acknowledges financial support from the  LabEx UnivEarthS  ( ANR-10-LABX-0023  and  ANR-18-IDEX-0001 ). Computing was partly done using the  Division Informatique de l'Observatoire (DIO) HPC  facilities from  Observatoire de Paris  (http://dio. obspm. fr/Calcul/)and at the  FACe (Francois Arago Centre) in Paris.
ACKNOWLEDGMENTS The Necker laboratory is supported by  Association Laurette Fugain ,  La Ligue  contre le Cancer, and the  INCa CARAMELE Translational Research  and PhD programs. The Martens laboratory was supported by the  European Union 's  Seventh Framework Programme  ( FP7/2007-2013)  under grant agreement  282510-BLUEPRINT  and the  Dutch Cancer Foundation  ( KUN 2011-4937 ). J. B. was supported by a  Kay Kendall Leukaemia Fund   Intermediate Research Fellowship  and by the  National Children's Research Centre, Children's Health Ireland at Crumlin (Dublin, Ireland). N. D. was funded by the  Medical Research Council UK. We thank  Nicolas Goudin  for assistance with immunofluorescence analysis. The  Institut Necker Imaging Facility  is supported by  Fondation ARC.