dataesr/scientific-paragraphs-categorization huggingface dataset:
Patients and methods/Materials and methods: A 16-month prospective analytic study (September 2020-December 2021) including all patients (without a chronic kidney failure history) admitted to ICU for critical forms of COVID-19. The patients were divided into two groups: -Group 1: patients who developed AKI during ICU stay. -Group 2: patients who have maintained normal kidney function. The KDIGO classification was adopted to stratify the AKI. The statistical analysis was performed using SPSS 23. Results: Overall 140 patients were included. Twenty-three per cent developed AKI (33 cases in group 1 and 107 in group 2). The mean age was 58 ± 13 with male predominance (sex ratio 1. 2). The most common comorbidities were hypertension (64%) and diabetes (62%). The mean IGS II and APACHE II were 40 ± 13 and 13 ± 6 respectively.
Conclusion: The occurrence of AKI in critical forms of COVID-19 was frequent in our study and was associated to a higher mortality. Septic shock was the main risk factor of AKI. These results need to be confirmed by further larger studies. Compliance with ethics regulations: Yes in clinical research. Rationale: Kidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific treatments of COVID-19 and ARDS on the risk of severe acute kidney injury (AKI) in critically ill COVID-19 patients. Patients and methods/Materials and methods: In our cohort study, we retrospectively analysed a database of consecutive patients hospitalized in 6 ICUs for COVID-19.
01). New-AF was significantly associated with greater use of ino-Rationale: Adults who have been infected with SARS-CoV-2 can develop a multisystem inflammatory syndrome (MIS-A), including myocarditis. Yet, several patients fail to meet MIS-A criteria, suggesting the existence of distinct phenotypes of COVID-19 related myocarditis. The objective of this study was to compare the characteristics and clinical outcome between patients with COVID-19-related myocarditis fulfilling MIS-A criteria (MIS-A+) or not (MIS-A-). Patients and methods/Materials and methods: We retrospectively reviewed the prospectively constituted database of our 26-bed ICU between March 2020 and June 2021, and included all patients admitted for suspected myocarditis with proven SARS-CoV-2 infection, without vaccination against COVID-19.
Data are missing about impact and risk factors of this complication. Patients and Methods/Materials and Methods: We conducted a monocenter and retrospective study from January 2010 to September 2019 including all patients hospitalized after a CA who were treated by stent andhad a second coronary angiography in the 3 following months. Demographics and characteristics of patient care were compared according to ST. Long-term follow-up was provided using the French National Healthcare Insurance database. Results: 22 patients met the inclusion criteria during the study period. The incidence of ST was 50%. Stent length was associated with ST occurrence (26. 8 mm vs 17. 0 mm, p = 0. 023), whereas there was no significant difference on age, gender, coronary lesion features, type of stent or drugs used.
We noted the hourly delays between the accident and the realization of the thoracic computed tomography (CT), as well as the delay between the admission to the hospital and the realization of the thoracic CT. We investigated the impact of thoracic CT on morbidity and mortality. The data were entered with the EPIINFO 7 software and analyzed using the SPSS statistics 23 software. The statistical tests are significant from p ≤ 0. 05 Results: The mean age of the patients was 33. 6 ± 17. 9 years with a male predominance (sex-ratio = 4M/1F). 98. 8% were polytraumatized. The mean ISS score was 34. 5 ± 8. 9; 68% of patients arrived with at least one vital distress. The delay between the thoracic radiological assessment and the time of the accident was less than 6 h in 73% of the patients. Furthermore, early assessment of injuries improved mortality (p = 0.
Annals of Intensive Care 2022, 12(1):FC-044 Rationale: Intensive care unit (ICU) hospitalizations of elderly patients with acute respiratory infection (ARI) have increased; however, we observed an important mortality during the ICU stay and in the first year of hospital discharge. Yet many physicians have doubts as to whether elderly patients benefit from ICU admission. Our hypothesis is that healthcare trajectories before critical illness might be used as surrogate of frailty that can be useful for the decision-making. The aim of this study was to assess whether the healthcare trajectories in the 3 months preceding ICU admission were associated with 1-year survival in elderly patients with ARI. Patients and methods/Materials and methods: A national population-based cohort study was performed from hospital discharge databases (2013-2017) and included ICU patients ≥ 80 years old with an ARI.
Patients and methods/Materials and methods: We conducted an analytical descriptive retrospective study of 50 cases of community peritonitis hospitalized in the surgical emergency resuscitation department over a period from January 2018 to June 2020. All patients over 65 years of age who were admitted for community peritonitis and who received medical and surgical care were included in this study. The parameters studied are demographic data, clinical and paraclinical signs, management and patient evolution. The Statistical analysis was performed using SPSS software, the evaluation of prognostic factors using a univariate and multivariate analysis.
Patients and methods/Materials and methods: This was a PK study performed in an ICU over 1 year. All patients who were prescribed fluconazole with at least two measured concentrations were included. A second dataset from a medical unit was also analyzed for comparison. Population PK modelling was performed by with Monolix software. Classical criteria were used for model evaluation including goodnessof-fit and simulation-based diagnostics. Patient covariates were investigated. Dosing simulations were performed with the final model with Simulx software. Various loading (LD) and maintenance doses (MD) were evaluated, and probability of target attainment (PTA) was computed in simulated patients (n = 1000). PK targets were set as a trough concentration (Cmin) of 15 mg/L and a daily AUC of 400 mg.
However, there are few data and conflicting results about corticosteroids therapy for critically ill patients with an AECOPD. Patients and methods/Materials and methods: In this study, using data from the observational longitudinal cohort OutcomeRea ™ database, with 32 french ICU centres participating, we assessed the impact of corticosteroid therapy for patients in ICU for an AECOPD. The prescription of corticosteroids therapy at admission was defined as a daily dose ≥ 0. 5 mg/kg of prednisone during the first 24 h after admission in ICU. We assessed the effect of corticosteroids on a main composite criteria including death and invasive mechanical ventilation (IMV) at day 28 after admission in ICU using an inverse probability of treatment weight (IPTW) estimator. Secondary outcomes were: survival analyse at D-28 and D-90, NIV failure, length of stay in ICU and in hospital, duration of ventilation, consumption of antibiotics and adverse effects of corticosteroids.
Despite frequent hospitalizations in ICUs, there is heterogeneity in treatment and global management due to a lack of ICU-specific guidelines. We aimed at gathering the medical practices of ICUs nationwide. Patients and methods/Materials and methods: We carried out an online survey that was sent to medical teams of all ICUs of French hospitals identified as expert centers in the Orphanet database (https:// www. orpha. net). Physicians from the same unit sent consensus answers to capture the usual care in their ICU, providing one survey answer per unit. The survey included sections related to: demography; usual pain management, and three clinical situations (hyperalgesic VOC, VOC with chest pain, and ACS with chest pain, dyspnea and fever). Results: Of 55 centers contacted, 29 (53%) answered the survey, including 18 (62%) university-hospitals, 10 (34.
Patients and methods/Materials and methods: This is a descriptive and analytical retrospective study spread over 5 years (January 1, 2015-December 31, 2020) in the pediatric intensive care unit including 47 cases. Statistical analysis is done using SPSS software. Results: In this study, we report 47 cases of septic shock in severe trauma patients collected in the pediatric intensive care unit of the children's hospital of CHU Ibn Rochd in Casablanca during the years 2015-2020. The study was carried out according to an operating sheet including demographic, clinical, biological, radiological and therapeutic data, followed by statistical analysis using SPSS software 20. The average age is 75 months with a male predominance. The sites of infection were, in descending order, respiratory infection, bacteremia, urinary tract and skin.
Patients and methods/Materials and methods: This was a prospective randomized study (NCT04637347). We included adult patients requiring a CVC in the superior vena cava area. Patients with infection at puncture site, coagulopathy, contralateral pneumothorax, trauma of clavicle and distorted anatomy of the neck were excluded from the study. Patients were randomly divided into two groups: US-guided SCV catheterization using either SC approach (SCGr) or IC approach (ICGr). We used long-axis scanning in combination with in-plane technique for all catheterizations. The primary outcome was the first attempt success rate. Overall success rate, venous scanning time, number of punctures, number of redirections, puncture time, guidewire insertion time, overall catheterization time, incidence of difficulties in catheterization and mechanical complications were secondary outcomes.
Patients and methods/Materials and methods: The study included ten residents, it took place in three phases, -The first phase: The participating doctors benefited from a theoretical presentation on DTP followed by a practical demonstration lasting three hours. -A second phase: Over a period of three weeks consisted for the junior doctors, a phase in which between 25 to 35 DTCs were carried out. The evaluation by the referent was carried out at each DTC in order to detect any anomalies. -The third phase: Follows the previous phase, it consists of performing ten DTCs by each candidate in order to complete their learning curve. The data for each exam was collected by the candidate. The candidate also provides the results of his DTC as well as that carried out by the referent. This examination concerns the search for the right and left middle cerebral artery with the values of the systolic (Vs), average (Vm) and diastolic (Vd) velocities, the value of the pulsatility index (IP) and the duration of each examination.
Since 2019 this extreme context has been accentuated by unprecedented epidemic waves. We will present a systematic review to better identify the traumatic impact of ICU on healthcare and associated factors before and during the health crisis. Patients and methods/Materials and methods: We used Pubmed; Science direct and Ovid (APA) databases to identify all quantitative, qualitative and mixed studies examining PTSD in Intensive care workers between 2009 and 2022. Results: Of the 704 articles identified, only 8 met our inclusion criteria. 4 studies that were conducted before the COVID period showed that 3. 3% to 18. 2% of the surveyed intensive care workers had PTSD symptoms. The associated risk factors were life-threatening emergencies; exposure to death; management of organ and body donations; and situations experienced by caregivers as therapeutic overkill.
Patients and methods/Materials and methods: Study centres participating in the EVERDAC trial (evaluating early vs differed arterial catheter in ICU patients with acute circulatory failure, NCT03680963),  [1]  were randomized between two communication strategies: conventional communication or upgraded communication strategy (intervention) including personalized computer-generated emails of congratulations for inclusions according to inclusion rate. The primary outcome was the number of patients included in the EVERDAC trial 12 months after centre opening, analyzed in a quasi-Poisson regression considering the number of ICU beds available in the unit as an offset. Results: 264 patients were included in the EVERDAC study in the nine participating centres, 119 from intervention centres (median 28.
Conclusion: The study suggests that the realization of tracheal secretions through CTSS does not lead to bacterial contamination of the respiratory samples. The statistical analysis was performed using SPSS 23. Results: Overall 140 patients were included. The mean age was 58 ± 13 with male predominance. The most common comorbidities were hypertension (64%) and diabetes (62%). Four patients had auto immune disease history with immunosuppressor ongoing treatment. The mean IGS II and APACH II were 40 ± 13 and 13 ± 6 respectively. Fifty-nine bacterial HCAI were reported in 55 patients (group1 and group2 counted 55 and 85 patients respectively). Healthcare-associated pneumonia was the most common one (44 cases equal 74% of HCAI) followed by bacteremia (6 cases), urosepsis (3 cases), infection related to a central-line catheter (2 cases), infection of bedsores (2 cases) and colitis (2 cases).
The aim of the present study is to describe clinical features, ventilatory management and outcomes of critically ill adults admitted for COVID-19 related ARDS. Patients and methods/Materials and methods: This is a descriptive retrospective study carried out in a 12-bed medical intensive care unit (MICU) of a University Hospital from March 2020 to September 2021. All patients admitted for a critical COVID-19 related ARDS were included. Data on patients' characteristics at ICU clinical presentation, ARDS and COVID-19 severity, ventilatory management, ventilatory settings, airways pressures and outcomes were collected. The database served to inquire about several aspects of COVID-19 related ARDS that will be discussed through a series of studies. Results: During the study period, 442 patients were admitted for COVID-19 pneumonia, 409 (92.
Patients and methods/Materials and methods: We collected data from the prospective multicenter database ANTICOV involving 11 intensive care unit (ICU) of AP-HP. Eligible patients were admitted in ICU with pneumonia related to COVID 19 and were treated with initial CTC with dexamethasone. We compared patients receiving usual ICU care and patients receiving a secondarily high dose of CTC during ICU care (CTC group). Results: Between September 2020 and March 2021, we enrolled 593 patients. 61 patients (12%) received secondarily high doses of CTC during ICU care. Median delay between dexamethasone and high dose of corticosteroids was 16 days  [9-27. 5]. There was no between-group difference for median SOFA admission. ICU mortality was higher in the CTC group (48%) as compared with usual care (28%) (p = 0.
Stage I scorpion envenomation were excluded. Statistical analysis was performed using the statistic software SPSS 20. Results: Sixty-six patients were included. Mean age was 29 ± 20 years (1 to 84 years old) with female predominance (sex-ratio = 0. 8). The majority of patients (90%) were staged II according to severity. Among demographic factors, age (p = 0. 007) and the mode of transport in the acute care unit (p = 0. 001) were predictor factor of mortality. However, comorbidities and gender had no prognostic impact. Clinical predictor factor of mortality on admission were: agitation (p < 0. 001), dyspnea (p = 0. 02), abdominal pain (p = 0. 03), rapid breathing (p = 0. 01), oxygen saturation (p = 0. 04), priapism (p = 0. 01) and the presence of signs of shock (p < 0. 001): marbling, cool skin.
This technique is already well recognized. The aim of this work was to analyze the relationship between the rate of full stomach and the SOFA score and its impact on the tolerance of enteral nutrition. Patients and methods/Materials and methods: This prospective observational cohort study received approval (n°: L16-174) from the ethics committee (Comité pour la Protection des Personnes Sud-Est IV, Centre Léon Bérard, Lyon, France) and was registered in the public registry ClinicalTrials. gov, no. NCT03205592. In this prospective multicenter study, adult patients under mechanical ventilation were included, except supra-mesocolic surgery patients. Ultrasound examination of the gastric antrum was daily measured for five days long. Correlation was computed according to the method described by Bland and Altman specifically designed in order to compute correlation coefficient for repeated observation.
Patients and methods/Materials and methods: We conducted a single-centre observational study over 6 years. Clinical data were collected retrospectively, microbiological data were collected prospectively. All consecutive patients over 18 years admitted to ICU with documented SCAP were included. All patients received an empirical combination therapy with a β-lactam plus a macrolide or quinolone. Legionella urine antigen test (UAT) was performed in all patients at admission. Macrolide or quinolone were discontinued if the UAT was negative. We examined the clinical and epidemiological characteristics of SCAP and analyzed the independent factors associated with ICU mortality. Results: On 856 SCAP, 26 patients had atypical pneumonia: 18 Legionella pneumophila (LP) serogroup 1, 3 Mycoplasma pneumoniae (MP), and 5 Chlamydia psittaci (CP).
They were put back in the supine position around 11 AM the morning following the second night. Demographic data, data regarding the incidence of pressure injury and ventilation parameters were collected retrospectively on medical and nurse files of charts. Results: For the 81 patients included, the median duration of prone positioning sessions was 39 h (interquartile range (IQR) 34-42) and patients benefited from a median of 2 sessions (IQR 1-4). The cumulated incidence of grade ≥ II pressure injuries was 26% (95%CI 17-37) and 2. 5% (95% CI 0. 3-8. 8) for stages III/IV pressure injuries. This increased duration was associated with additional increase in oxygenation after 16 h with the PaO2/FiO2 ratio increasing from 150 mmHg (IQR 121-196) at H + 16 to 162 mmHg (IQR 124-221) before being turned back to supine (p = 0.
Patients and methods/Materials and methods: In this single-center study conducted in a 20-bed adult-ICU, consecutive admission for CARDS were screened for eligibility. Patients who underwent invasive mechanical ventilation (IMV) within 6 h upon admission were excluded. We collected clinical data and lab findings from admission until HFNC weaning or intubation which defined HFNC failure. ROX index was recorded at H0, H2, H6, H12 and H24. We also measured PF ratio evolution, monitored FiO 2 and respiratory rate (RR). High work of breathing (HWOB) was defined as a respiratory rate (RR) above 30 cpm and/or excessive accessory muscle use. Results: 230 patients were included until August 2021. 61. 5% (n = 141) men, median aged 62 years [IQR 53-70] with SAPS-II at 28 ± 8, PF ratio 132 ± 63. 8 under FiO 2 0.
Recent studies have reported a low rate (< 10%) of early bacterial co-infection among patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, and significantly lower compared to patients with influenza pneumonia (1). We aimed to determine the performance of procalcitonin (PCT) to diagnose early bacterial pulmonary co-infection within 48 h after intubation in critically ill patients with SARS-CoV-2 or influenza pneumonia. Patients and methods/Materials and methods: We performed a post hoc analysis of data from the multicenter retrospective coVAPid cohort study. Adult patients receiving invasive mechanical ventilation for at least 48 h for SARS-CoV-2 (first wave in Europe) or influenza pneumonia (2016-2020 admissions), and with at least one PCT measurement within 48 h after intubation were considered for the present analysis.
57, CI95% [1. 14; 2. 17 Rationale: Physiological changes during pregnancy have a significant impact on the immune system, respiratory system, cardiovascular function, and coagulation. The impact of SARS-CoV-2 in pregnancy remains to be determined. Our study aim to describe the characteristics of COVID19 infections in per partum patients before vaccine authorization. Patients and methods/Materials and methods: A retrospective and descriptive study of 9 months duration carried out in the COVID intensive care unit including all per partum patients with COVID 19 pneumonia between March 2021 and September, 2021. All pregnant or immediate postpartum women hospitalized for SARS-CoV2 infection were included. Demographic, clinical, biologic, radiographic, therapeutic and outcomes data were collected.
The primary endpoint was maternal mortality. Two groups were identified: Group 1 = Survivors and Group 2 = Deceased. The differences in data of the patients were evaluated. Results: During the study period, we collected 17 patients. The incidence of COVID19 infection in per partum patients was 5% in our series. All patients were admitted postpartum (75% by caesarean section). The median age was 31(25-38) years. The comorbidities were chronic respiratory deficient (3 patients) and hypothyroidism (3). The mean BMI was 28 ± 3 kg/m 2. All patients were unvaccinated. Seven were multiparous. The mean gestational age was 27 ± 6 weeks of amenorrhea. The mean PaO2/FiO2 ratio at admission was 98 ± 35 mmHg. All patients admitted to the ICU were in respiratory distress. Severe ARDS was observed in 11 patients (64%).
Infection was confirmed by RT-PCR, rapid test, or chest CT scan. Epidemiological, clinical, biologic and radiographicl data and outcomes were collected. Results: Thirty-six patients were included with a mean age of 33 ± 5 years and a mean term of pregnancy of 34 ± 4 weeks. The median consultation time after the onset of symptoms was 3. 5 days [1;7] and the median hospital stay was 4 days [1;7]. Among 36 pregnant women, no one of the patients was vaccinated against SARS-Cov-2. Eleven patients (34%) were hospitalized in the ICU. Symptoms were dominated by respiratory signs, cough and dyspnea, respectively 21 (65%) and 15 (47%) patients. The different ventilatory supports were: single oxygen therapy (50%), high concentration mask (34%), high flow oxygen therapy (12. 5%), and invasive ventilation (16%).
With Electrical Impedance Tomography (EIT) it is possible to measure the distribution of ventilation in each lung in order to describe asymmetrical lung injury. Moreover, each lung respiratory mechanic and PV curve can be assessed with an EIT derived method. In the present study, we hypothesized that some patients may have asymmetrical ARDS where EIT would provide different information from those obtained from global P-V curves. Patients and methods/Materials and methods: Prospective study (NCT04386720). We recorded the low flow PV curve without PEEP of the ventilator in order to assess airway closure and the recruited volume. 1 AT the same time with EIT we analyzed the derived PV curves of each lung. 2 A difference of tidal ventilation of at least 20% between the 2 lungs was considered as asymmetrical ARDS.