dataesr/scientific-paragraphs-categorization huggingface dataset:
As we implement these RUNX1-specific rules, the variant annotation in ClinVar will contain a link to the specific version of the MM-VCEP RUNX1 evidence rules, a summary of the specific evidence codes used for that variant, and a link to the ClinGen evidence repository where all the evidence evaluated for that variant is found. Given these detailed expert-reviewed curations, MM-VCEP-curated variants will be submitted under a "3-star expert panel reviewed" FDA-recognized designation. We expect that our RUNX1-specific rules will require further updating as additional data become available, or at a minimum every 2 years, and will address improved computational modeling, functional assays, and larger and more ethnically diverse population databases. Per ClinGen policy, RUNX1 VUS and LPATH variants will be reassessed by the expert panel every 2 years, and other variants may be re-curated if discrepancies in the variant classification or new evidence emerge over time.
When they became the first chief editors of the International Review of Social Psychology (IRSP), the goal of Robert Pagès and Janine Larrue was to provide better access to specialized literature of the discipline at a time when it was scarce  (Delouvée, 2013; Pagès, 1979). Their legacy continues today. The journal, which is now 30 years old , evolved to follow the evolution of research in social psychology. In this special occasion, our contribution intends to retrace the history of the IRSP, from its roots through its latest developments. We begin by describing the genesis and evolution of the journal. We then analyze some characteristics of the articles that have been published during the 30 years of existence of the journal and their evolution over time. A final goal of this contribution was to develop and make the database (containing the characteristics of the articles and used for the following analyses) accessible.
Béatrice Degraeve and Stéphanie Rambaud When they became the first chief editors of the International Review of Social Psychology (IRSP), the goal of Robert Pagès and Janine Larrue was to provide better access to texts and research in social psychology. Their legacy continues and extends today. For the 30th anniversary of the journal, the following contribution intends to retrace its origins and evolutions. Following an overview of the history of IRSP, we propose to analyze the characteristics of the articles that have been published during the 30 years of existence of the journal and their evolution over time. For this purpose, we developed a database-available at: osf. io/69x47-containing the characteristics of the articles published between 1988 and May 1, 2018 (i. e. , for each year: title of the articles, volume, type, authors' names, sex and institutional affiliation, length and associated keywords).
This database can be useful to browse IRSP's literature and facilitate reference search, but can also be used for further research on the evolution of the scientific literature in social psychology (e. g. , analysis of the characteristics of the authors/published contents of the field). d  'Allonès, 1960). Robert Pagès (researcher in social and sociopolitical psychology) later took over the management of the laboratory, which was established after 1968 at Université Paris 7  (Deconchy, 2007; Demailly, 2009). For a few years  (1979) (1980) (1981) (1982) (1983) (1984) (1985) (1986) (1987) , the laboratory published a journal entitled Recherches de Psychologie Sociale (Social Psychology Research, see Figure  1 ). In the editorial of the first issue, Robert Pagès presented the journal as ' an initiative of the Laboratory of Social Psychology of Université Paris 7 (the former social psychology laboratory of Sorbonne Université), associated with the National Center for Scientific Research' and the issue as ' a first volume of a publication [we] hope to renew with increasing regularity'  (Pagès, 1979: 3, our translation).
The goal of Robert Pagès and Janine Larrue was to create a journal that would provide a better access to texts and research in social psychology. Their legacy continues and extends today. Following the evolution of the research, the association and its journal have been able to adapt through the implication of a dedicated community. Aside from this overview of the history of IRSP, another goal for our contribution is to analyze some characteristics of the articles that have been published during the 30 years of existence of the journal and their evolution over time. For this purpose, we developed a database containing the characteristics of the articles (i. e. , for each year: title of the articles, volume, type, authors' names, sex and institutional affiliation, length and associated keywords).
Method We collected information about IRSP publications directly from the IRSP volumes  (from 1988 to 2005)  or from available information on online platforms (i. e. , CAIRN from 2006 to 2015 and Ubiquity from 2016 to 2018). Specifically, we gathered information about each article published from 1988 to 2018: name, sex and institutional affiliation of the author(s), length and associated keywords of the articles. We also collected information about the IRSP's successive editorial committees (i. e. , name and affiliation of the editors in chief and associate editors), which appeared at the beginning of each volume. When the authors' first names were not available (only the initials were reported from issue 1994 to issue 1998) and when we could not know authors' sex (men or women) by any other available information, we reported missing data (N = 42; 2.
Note that we considered authors as 'French' when there was at least one author affiliated to a French university among the authors. This includes the case where (1) all the authors of a publication were affiliated to a French University (i. e. , 'French affiliation'), and the case where (2) French author(s) co-wrote with non-French author(s) (i. e. , 'Mixed affiliation', see details in Appendix D). During   (1988 -1997; 1998 -2007; 2008 -May 2018)). data collected from Web of Science do not allow us to know the number of official citations for the documents published before 2006. We noticed that publications from 2008 show the highest score of cited publications (see Table  3 ). The most cited publication is from 2008 (i. e. ,  Linnenbrink-Garcia, Tyson & Patall, 2008)  with a total of 72 citations and an average of 6.
55 citations per year. The impact factor (IF) is a journal-level bibliometric index based on citation analysis  (Garfield, 1972). Although the IF (and journal-level bibliometric indexes in general) has not been spared from criticism (e. g. ,  Hegarty & Walton, 2012; Seglen, 1997) , it has been extensively used in the past decades as an index of quality of scientific journals  (Garfield, 2006). Due to a recent name change in the database, Web of Science considers now IRSP as two separate journals. The first one, which includes the English and French title of the review, has an impact factor of 0. 579 and an Eigenfactor score of 0. 000260 with a total of 189 citations. The second one, which take into account the new title from 2016 as a new journal, has an impact factor of 1. 417, an Eigenfactor score of 0.
Thus, many indicators show that accessibility has been-and continues to be-an important concern for the IRSP. To trace the evolution of the IRSP and its scientific literature, we developed a database containing the characteristics of the articles from 1988 to May 2018. We believe that it can be a useful tool as it allows browsing many types of information (e. g. , title of the articles, type or associated keywords) and thereby finding resources on specific topics or look for the work of some authors. We hope that this database will contribute to facilitating research of the scientific literature published in the journal since 1988  (and through May 1, 2018). Note that we did not discuss the evolution of the male/female ratio (among the authors or the editorial committee) or the evolution of thematic approaches in the IRSP.
Acknowledgements The authors would like to thank  Jean-Léon Beauvois ,  Olivier Desrichard ,  Nicole Dubois ,  Marie-Axelle Granié ,  Janine Larrue ,  Jean Marc Monteil ,  Christine Morin-Messabel ,  Patrick Rateau  and  Pierre Tap , who helped us gather information about the journal and trace its history. We are very grateful and honored to have investigated the history of the IRSP with you. The authors of course assume full responsibility for this text and any errors it may contain. The authors also would like to thank  Céline Darnon  and  Olivier Klein  for their support and assistance with this project-but also for.
Image analysis In the plant-scale experiments, the spatio-temporal responses of the coleoptiles were measured using the same software that was developed and described by  Chauvet et al. (2016). The topological skeleton of coleoptile was first extracted and then analysed to compute the response of the coleoptile length over time, L(t) and of the tip angle, θ tip (t) (Fig. 1 ), defined as the spatial mean inclination of the skeleton at the tip over a length equal to two mean coleoptile diameters. This inclination was measured relative to the direction of the local gravity (vertical at g eff =1g and inclined at g eff =3g). For experiments at the cell scale, the bright-field microscopy images are analysed using a specific Python script and the scikit-image library (van der  Walt et al. , 2014).
Acknowledgements This work was supported by  ANR   Blanc Grap2  ( ANR-13-BSV5-0005-01 ),  Labex MEC  ( ANR-10-LABX-0092 ), the  AMIDEX  project ( ANR-11-IDEX-0001-02 ) funded by the  French government program  Investissements d'avenir, the  European Research Council  under the  European Union Horizon 2020 Research and Innovation programme  (grant agreement No  647384 ) and the  French Space Agence (CNES).
The as-prepared Mg 2 Ta 2 N 4 exhibits a cation-disordered cubic crystal structure (Figure  2A ) with Mg and Ta in octahedral coordination and cell parameter a = 4. 35329(6) Å, as determined by Rietveld refinement of the SXRD data (see Figure  S2A  in the Supporting Information. Refinement was made using Fm3̅ m space group as reported in ref 26). An Mg/Ta ratio of about 0. 8 and 0. 7 was obtained by EDX analysis, and N content of 9. 5% wt was obtained from chemical analysis, in agreement with the nominal composition. A typical scanning electron microscopy (SEM) micrograph of the Mg 2 Ta 2 N 4 sample is shown in Figure  2B , displaying nanometric particles forming micrometric size aggregates with distribution of Mg and Ta being homogeneous (see Figure  S2B ). When subjected to oxidation using an electrochemical potential spectroscopy (EPS) protocol at 100 °C in Li threeelectrode cells in 1 m LiBOB, EC/PC 1:1 vol electrolyte, the electrodes containing Mg 2 Ta 2 N 4 exhibited a potential profile displaying a plateau around 4.
Two wide bands appear in the DOS: the upper and partially filled band dominated by the Ta d-states and the lower band (between -2 and -7 eV) which is mostly of N p character. Ca deintercalation from CaTaN 2 to form Ca 0. 5 TaN 2 would imply the upper band, this is to say, the oxidation from the formal state Ta 4+ to Ta 5+. Beyond the Ca 0. 5 TaN 2 composition (or NaTaN 2 for the analogous phase), Ca de-insertion would reduce the occupancy of the lower N(2p)-band producing a large amount of holes and in the end nitrogen oxidation with concomitant structural degradation. Yet, and in line with the experimental findings discussed above, a mechanism for CaTaN 2 oxidation additional and/or alternative to deintercalation should also be considered. Thus, one can postulate possible oxidation/decomposition reactions for Ca x TaN 2 yielding other known phases in the Ca-Ta-N system, which are the potential stable phases according to the calculated phase diagram in the Materials Project database.
9999%) atmosphere. Temper-atures of 1080, 850, and 1100 °C were employed for the synthesis of CaTaN 2 , MgTa 2 N 3 , and Mg 2 Ta 2 N 4 , respectively, with 300 °C/h heating rate. After the thermal treatment, the samples were naturally cooled in the furnace. All the thermal treatments were carried out in Mo (Alfa Aesar, 99. 95%) crucibles inside a silica tube, using Zr foil (Goodfellow, 99. 2%) as sample holder caps and tube inlet traps in order to avoid water and oxygen contaminations. 4. 2. Structural, Morphological, and Composition Characterization. X-ray powder diffraction data were acquired using borosilicate glass capillaries of 0. 3 or 0. 5 mm diameter as sample holders. Laboratory X-ray powder diffraction data were collected using a Bruker D8 Advance A25 diffractometer in a Debye Scherrer configuration equipped with Mo Kα 1 radiation source (λ = 0.
7093 Å) and Johansson monochromator. Synchrotron X-ray powder diffraction (SXRPD) patterns were collected at the MSPD beamline  19  of ALBA Synchrotron light source (Cerdanyola del Valles, Spain) using mythen bank of detectors with λ = 0. 6199 Å (MgTa 2 N 3 and Mg 2 Ta 2 N 4 ) or 0. 41338 Å (Ca x TaN 2 ). The capillaries were rotated during data acquisition. Rietveld refinements were performed using the program FullProf. 20 he amorphous content of Ca x TaN 2 was determined by fullquantitative analysis, adding to the samples a known amount (20% wt) of purely crystalline SiO 2 standard. 21  contents were determined by combustion analysis in oxygen in a Thermo Fisher Scientific instrument, heating the samples in oxygen up to 1060 °C. SEM images and EDX analyses were performed by using an FEI Quanta 200 FEG microscope under high vacuum operating at 20 kV; secondary and backscattered electron detectors were used.
Introduction: In VOYAGE 1 (NCT02207231) and VOYAGE 2 (NCT02207244), guselkumab, an interleukin-23 blocker, was safe and effective in patients with moderate-to-severe plaque psoriasis. Methods: Patients who self-identified as Hispanic (n ¼ 117) or non-Hispanic (n ¼ 1686) were randomized to guselkumab, placebo, or adalimumab. Efficacy assessments included Psoriasis Area and Severity Index (PASI), Investigator's Global Assessment (IGA), and Dermatology Life Quality Index (DLQI). Results: At week 16, treatment differences for guselkumab versus placebo in the Hispanic and non-Hispanic populations were 67. 4 (95% confidence interval 50. 4, 84. 4) and 77. 2 (73. 5, 80. 8) percentage points for IGA 0/1 and 59. 2 (41. 9, 76. 4) and 69. 2 (65. 7, 72. 7) percentage points for PASI 90, respectively. Treatment differences for guselkumab versus adalimumab were 25.
Study assessments The co-primary endpoints in VOYAGE 1 and VOYAGE 2 were an IGA score of 0 (cleared) or 1 (minimal)  (16)  and !90% improvement in the PASI score  (17)  from baseline (PASI 90) at week 16. Secondary endpoints included !75% and !100% improvement in PASI score from baseline (PASI 75 and PASI 100) and a Dermatology Life Quality Index (DLQI) score of 0 or 1 (DLQI 0/1; no effect at all on patient's HRQoL)  (18). For this analysis, pooled efficacy data for the Hispanic and non-Hispanic patient populations from VOYAGE 1 and VOYAGE 2 were analyzed at week 16 and week 24. To evaluate safety, pooled data on treatment-emergent adverse events (TEAEs) for the Hispanic and non-Hispanic patient populations from VOYAGE 1 and VOYAGE 2 were analyzed through week 28.
Statistical analyses Efficacy and baseline characteristics analyses were based on all patients who were randomized at week 0 according to their assigned treatment. Safety analyses were based on patients who received at least 1 dose of study agent according to the actual treatment received during the study. The Cochran-Mantel-Haenszel chi-squared test stratified by study was used to compare the proportion of patients responding to treatment. Treatment differences and confidence intervals (CIs) were adjusted by study (VOYAGE 1 and VOYAGE 2) with Cochran-Mantel-Haenszel. After the treatment failure rules were applied, the remaining missing data were handled using nonresponder imputation.
RESULTS Genome assembly of the P. halstedii pathotype 710 Genome assembly features. We generated and annotated a genome assembly of P. halstedii pathotype 710 (Figure  S1 , Table  S1 , see Methods). Metrics comparisons with the published P. halstedii assembly (strain OS-Ph8-99-BlA4,  Sharma et al. , 2015)  suggest that our assembly is less fragmented, as it is composed of less scaffolds (745 versus 3162), less contigs (devoid of 'N') (3051 versus 7857) with a larger N50 for our genomic contigs (56. 4 kb versus 16. 2 kb). Our final assembly has a total length of 67. 6 Mb. Its completeness was assessed using BUSCO 3. 0. 2 (Waterhouse et al. , 2018). This indicated the presence of 87. 2% of the conserved genes from the Stramenopiles and Alveolata database at the genome level, and 88. 9% at the proteome level, similar to the earlier published proteome (Table  S2 ).
We predicted by SignalP  (Nielsen, 2017)   S4 ). We performed a systematic analysis of protein domains of the 354 RXLR predicted proteins using Mkdom2  (Gouzy et al. , 1999). The resulting network computed from domain sharing contains 482 edges and 465 nodes, with 354 proteins and 111 protein domains (Figure  1 , Figure  S3 , Table  S5 ). It is composed of 40 connected components (CC: connected parts of the graph in which any node (domain or protein) can be reached from any other node by a path), and 112 singletons that do not share any domain with others (Figures  1, S3 ). The largest CC01 contains 37 nodes (21 proteins and 16 shared domains) and the smallest only two proteins and one domain (CC29 to CC40). BlastP analyses of the 354 predicted P. halstedii RXLR peptides were performed on all oomycete sequences from the nr protein database (nr 2017/01/10), in order to define their conservation level in other oomycete species (E-value < 10 À4 ).
For these reasons, we estimated that at least 78% (277) of our list (no hit, hit with unknown Ph. infestans protein, or hit with Ph. infestans RXLR) could be reliable RXLR effectors. Seventy-one were specific for P. halstedii only, and 53 for P. halstedii and P. viticola. Interpro domains and WY-domain folds in P. halstedii RXLR. To assess our network and to look for known protein domains, Interpro motifs were searched in the 354 P. halstedii RXLRs. One-third (104) of the putative RXLRs matched with Interpro domains, including three with the RXLR phytopathogen effector protein domain IPR031825  (Boutemy et al. , 2011). The most frequent Interpro domains were the alpha/beta hydrolase fold (IPR029058), the HECT domain (IPR000569) present in E3 ubiquitin-protein ligases, the DnaJ domain (IPR001623) present in chaperones, the short-chain dehydrogenase/reductase (IPR002347) and the protein kinase-like domain (IPR011009), each of these clustered in a similar CC, suggesting that our network using Mkdom2 was relevant.
PhRXLR-C09 and PhRXLR-C11 also targeted nuclei and plasma membranes (Figure  4f, g. No other BlastP hit with an E-value <10 À4 were found on nr database of ncbi. c Pearson correlation below 0,9 (see Fig. 2 ). Abbreviations: Connected Component (CC), singleton (S), WI  (Win et al. , 2012) , WH  (Whisson et al. , 2007) , H  (Bhattacharjee et al. , 2006) , Blast (B), Nucleocytoplasmic (NC), Plasma membrane (PM), Endomembrane system (EMS). © The non-nuclear effector constructs targeted diverse plant cell components (Table  1 ). PhRXLR-C29 and PhRXLR-C30 were, respectively, observed in plasma membrane and plasma membrane and tonoplast membrane (Figures  4h, 5d, e ). Seven effectors targeted the endomembrane system. The fluorescent signals observed for PhRXLR-C13, -C21, -C22 and -C26 fusions clearly depicted the endoplasmic reticulum networks (Figures  4i-j, S5 ).
, 2006; Whisson et al. , 2007; Win et al. , 2012)  with a workflow for RXLR detection developed on the Galaxy web platform  (Cock and Pritchard, 2014). BlastP was made against an RXLR reference dataset and only hits with an E-value <10 À5 were retained. This reference dataset consisted of 2663 proteins described as (putative) RXLR in 14 oomycetes and fungi species (Table  S13 ). Proteins containing WY folds were searched in the whole proteome using HMMER3 and an HMM model previously described  (Boutemy et al. , 2011). In total, 131 proteins containing 1-28 WY domains were found, among these, 86 had a SP prediction and 65 were present in the 354 RXLR list including two conserved cloned RXLRs. The 16 other pathotypes of P. halstedii were sequenced by Illumina technology (100 X), reads were mapped on the 710 genome assembly and RXLR polymorphism determined (Figures  S1  and S3 , Table  S4 ).
RNA-seq experiments RNA extractions were performed as previously described  (Gascuel et al. , 2016b). RNA-seq libraries were prepared at the GeT-PlaGe facility (Toulouse, France) from mRNA selected using poly-T beads, according to the Illumina TruSeq Stranded mRNA sample prep kit protocols. RNA-seq read pairs were mapped on P. halstedii 710 genome using the glint software with parameters set as follows: matches ≥50 nucleotides, ≤4 mismatches, no gap allowed, only best-scoring hits taken into account (Table  S6 ). Ambiguous matches (same best score) were removed. Statistical treatment of the mapped reads was carried out with under [R] environment using the DESeq package  (Love et al. , 2014). Independent filtering and outlier detection methods proposed by the package were used. Genes presenting a false-discovery rate (FDR)-corrected P-value ≤0.
DATA AVAILABILITY Genome assembly and annotation data of the P. halstedii pathotype 710 have been deposited in DDBJ/ENA/GenBank under accession number PDFJ00000000. 1 and are available at https://doi. org/10. 15454/1. 5083166732793875e12. Illumina raw data of genome and RNA-seq reads have been deposited in the SRA under study accession number SRP151444 (Tables  S1, S6 ).
Data collection and collation Data holders were approached through networks of researchers with the aim of collecting raw data from a representative sample of studies performed in European crops. After initial collection, data were screened for missing countries or crops systems, and requests were targeted at researchers having published in these areas. Of 77 proposed studies, 58 provided data with sufficient site replication and high resolution land-use maps (Table  S1 , Appendices S1, S2 in Supporting Information). Requested data were arthropod abundance per unit area and time (species richness when available) and measures of pollination, pest control and yields, sampled along gradients of landscape composition and configuration in ≥8 sites. Sites included annual and perennial crop fields, managed grasslands, field margins and orchards.
Landscape variables We used land-use maps provided by data holders to calculate landscape variables for all studies. First, we standardized map classification to five land-use classes (arable, forest, seminatural habitat, urban and water). Semi-natural habitat included hedges, grassy margins, unmanaged grasslands, shrubs, fallows (Appendix S1). We then calculated variables in six circular sectors of 0. 1 to 3 km radius around sites (Appendix S1, Fig. S1 ). Several indices can be used to describe landscape composition, including % arable land and % semi-natural habitat (SNH) (e. g. Chaplin-Kramer et al. 2011). To test the importance of these land-use classes, we selected % SNH and % arable land as measures of landscape composition and used them in parallel sets of models to avoid collinearity (see Statistical analyses).