Acknowledgments The LAS VEGAS-investigators  AUSTRIA LKH Graz ,  Graz: Wolfgang Kroell ,  Helfried Metzler ,  Gerd Struber ,  Thomas Wegscheider AKH Linz , Linz:  Hans Gombotz Medical University Vienna :  Michael Hiesmayr ,  Werner Schmid ,  Bernhard Urbanek BELGIUM UCL-Cliniques Universitaires Saint Luc Brussels :  David Kahn ,  Mona Momeni ,  Audrey Pospiech ,  Fernande Lois ,  Patrice Forget ,  Irina Grosu Universitary Hospital Brussels (UZ Brussel ):  Jan Poelaert ,  Veerle van Mossevelde, Marie-Claire van Malderen Het Ziekenhuis Oost Limburg  (ZOL), Genk:  Dimitri Dylst ,  Jeroen van Melkebeek, Maud Beran Ghent University Hospital , Gent:  Stefan de Hert ,  Luc De Baerdemaeker ,  Bjorn Heyse ,  Jurgen Van Limmen ,  Piet Wyffels ,  Tom Jacobs ,  Nathalie Roels ,  Ann De Bruyne Maria Middelares , Gent:  Stijn van de Velde European Society of Anaesthesiology, Brussels :  Brigitte Leva ,  Sandrine Damster ,  Benoit Plichon BOSNIA HERZEGOVINA General Hospital  'prim  Dr Abdulah Nakas' Sarajevo :  Marina Juros-Zovko ,  Dejana Djonoviċ-Omanoviċ CROATIA General Hospital Cakovec, Cakovec: Selma Pernar General Hospital Karlovac, Karlovac :  Josip Zunic ,  Petar Miskovic ,  Antonio Zilic University Clinical Hospital Osijek, Osijek :  Slavica Kvolik ,  Dubravka Ivic ,  Darija Azenic-Venzera ,  Sonja Skiljic ,  Hrvoje Vinkovic ,  Ivana Oputric University Hospital Rijeka ,  Rijeka: Kazimir Juricic ,  Vedran Frkovic General Hospital Dr J Bencevic ,  Slavonski Brod :  Jasminka Kopic ,  Ivan Mirkovic University Hospital Center Split , Split:  Nenad Karanovic ,  Mladen Carev ,  Natasa Dropulic University Hospital Merkur , Zagreb:  Jadranka Pavicic Saric ,  Gorjana Erceg ,  Matea Bogdanovic Dvorscak University Hospital Sveti Duh , Zagreb:  Branka Mazul-Sunko ,  Anna Marija Pavicic ,  Tanja Goranovic University Hospital, Medical school, "Sestre milosrdnice" (Sister of Charity ), Zagreb:  Branka Maldini ,  Tomislav Radocaj ,  Zeljka Gavranovic ,  Inga Mladic-Batinica ,  Mirna Sehovic CZECH REPUBLIC University Hospital Brno ,  Brno: Petr Stourac ,  Hana Harazim ,  Olga Smekalova ,  Martina Kosinova ,  Tomas Kolacek ,  Kamil Hudacek ,  Michal Drab University Hospital Hradec Kralove ,  Hradec Kralove :  Jan Brujevic ,  Katerina Vitkova ,  Katerina Jirmanova University Hospital Ostrava, Ostrava :  Ivana Volfova ,  Paula Dzurnakova ,  Katarina Liskova Nemocnice Znojmo , Znojmo:  Radovan Dudas ,  Radek Filipsky EGYPT El Sahel Teaching hospital, Cairo: Samir el Kafrawy Kasr Al-Ainy Medical School, Cairo University: Hisham Hosny Abdelwahab, Tarek Metwally, Ahmed Abdel-Razek Beni Sueif University Hospital, Giza: Ahmed Mostafa El-Shaarawy, Wael Fathy Hasan, Ahmed Gouda Ahmed Fayoum University Hospital, Giza: Hany Yassin, Mohamed Magdy, Mahdy Abdelhady Suis medical Insurance Hospital, Suis: Mohamed Mahran ESTONIA North Estonia Medical Center, Tallinn: Eiko Herodes ,  Peeter Kivik ,  Juri Oganjan ,  Annika Aun Tartu University Hospital, Tartu :  Alar Sormus ,  Kaili Sarapuu ,  Merilin Mall ,  Juri Karjagin FRANCE University Hospital of Clermont-Ferrand, Clermont-Ferrand :  Emmanuel Futier ,  Antoine Petit ,  Adeline Gerard Institut Hospitalier Franco-Britannique, Levallois-Perret :  Emmanuel Marret ,  Marc Solier Saint Eloi University Hospital , Montpellier:  Samir Jaber ,  Albert Prades GERMANY Fachkrankenhaus Coswig , Coswig:  Jens Krassler ,  Simone Merzky University Hospital Carl Gustav Carus ,  Dresden: Marcel Gama de Abreu ,  Christopher Uhlig ,  Thomas Kiss ,  Anette Bundy ,  Thomas Bluth ,  Andreas Gueldner ,  Peter Spieth ,  Martin Scharffenberg ,  Denny Tran Thiem ,  Thea Koch Duesseldorf University Hospital, Heinrich-Heine University :  Tanja Treschan ,  Maximilian Schaefer ,  Bea Bastin ,  Johann Geib ,  Martin Weiss ,  Peter Kienbaum ,  Benedikt Pannen Diakoniekrankenhaus Friederikenstift , Hannover:  Andre Gottschalk ,  Mirja Konrad ,  Diana Westerheide ,  Ben Schwerdtfeger University of Leipzig , Leipzig:  Hermann Wrigge ,  Philipp Simon ,  Andreas Reske ,  Christian Nestler GREECE 'Alexandra ' general hospital of Athens, Athens:  Dimitrios Valsamidis , Konstantinos Stroumpoulis General air force hospital, Athens:  Georgios Antholopoulos ,  Antonis Andreou ,  Dimitris Karapanos Aretaieion University Hospital, Athens :  Kassiani Theodoraki ,  Georgios Gkiokas ,  Marios-Konstantinos Tasoulis Attikon University Hospital, Athens :  Tatiana Sidiropoulou ,  Foteini Zafeiropoulou ,  Panagiota Florou ,  Aggeliki Pandazi Ahepa University Hospital Thessaloniki, Thessaloniki: Georgia Tsaousi, Christos Nouris, Chryssa Pourzitaki ISRAEL The Lady Davis Carmel Medical Center, Haifa :  Dmitri Bystritski ,  Reuven Pizov ,  Arieh Eden ITALY Ospedale San Paolo Bari, Bari :  Caterina Valeria Pesce, Annamaria Campanile, Antonella Marrella University of Bari 'Aldo Moro', Bari: Salvatore Grasso, Michele De Michele Institute for Cancer Research and treatment, Candiolo, Turin :  Francesco Bona ,  Gianmarco Giacoletto ,  Elena Sardo Azienda Ospedaliera  per l'emergenza Cannizzaro, Catania:  Luigi Giancarlo ,  Vicari Sottosanti Ospedale Melegnano , Cernuso, Milano:  Maurizio Solca Azienda Ospedaliera -Universitaria Sant'Anna ,  Ferrara: Carlo Alberto Volta ,  Savino Spadaro ,  Marco Verri ,  Riccardo Ragazzi ,  Roberto Zoppellari Ospedali Riuniti Di Foggia -University of Foggia , Foggia:  Gilda Cinnella ,  Pasquale Raimondo ,  Daniela La Bella ,  Lucia Mirabella ,  Davide D' antini  IRCCS AOU San Martino IST Hospital, University of Genoa , Genoa:  Paolo Pelosi ,  Alexandre Molin ,  Iole Brunetti ,  Angelo Gratarola ,  Giulia Pellerano ,  Rosanna Sileo ,  Stefano Pezzatto ,  Luca Montagnani IRCCS San Raffaele Scientific Institute , Milano:  Laura Pasin ,  Giovanni Landoni ,  Alberto Zangrillo ,  Luigi Beretta ,  Ambra Licia Di Parma ,  Valentina Tarzia ,  Roberto Dossi ,  Marta Eugenia Sassone Istituto  europeo di oncologiaieo, Milano:  Daniele Sances ,  Stefano Tredici ,  Gianluca Spano ,  Gianluca Castellani ,  Luigi Delunas ,  Sopio Peradze ,  Marco Venturino Ospedale Niguarda Ca'Granda Milano , Milano:  Ines Arpino ,  Sara Sher Ospedale San Paolo -University of Milano , Milano:  Concezione Tommasino ,  Francesca Rapido ,  Paola Morelli University of Naples "Federico II" Naples: Maria Vargas, Giuseppe Servillo Policlinico 'P.