Title: Data Aggregation at the Level of Molecular Pathways Improves Stability of Experimental Transcriptomic and Proteomic Data
Authors: last_name: Borisov
first_name: Nicolas
name: Nicolas Borisov
corresponding: yes
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 2
institution: National Research Centre “Kurchatov Institute”
country: Russia
name: National Research Centre “Kurchatov Institute” , Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, 1, Akademika Kurchatova sq., Moscow, 123182, Russia
last_name: Suntsova
first_name: Maria
name: Maria Suntsova
affiliations: label: 3
institution: Pathway Pharmaceuticals
name: Pathway Pharmaceuticals , Wan Chai, Hong Kong, Hong Kong SAR
label: 4
institution: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
country: Russia
name: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow, 117997, Russia
last_name: Garazha
first_name: Andrew
name: Andrew Garazha
affiliations: label: 4
institution: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
country: Russia
name: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow, 117997, Russia
label: 5
institution: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology
country: Russia
name: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow, 117198, Russia
last_name: Lezhnina
first_name: Ksenia
name: Ksenia Lezhnina
affiliations: label: 5
institution: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology
country: Russia
name: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow, 117198, Russia
last_name: Kovalchuk
first_name: Olga
name: Olga Kovalchuk
affiliations: label: 6
institution: Department of Biological Sciences, University of Lethbridge
name: Department of Biological Sciences, University of Lethbridge , 4401 University Drive, Lethbridge, AB, T1K 3M4, Tel: 1-403-394-3916
label: 7
institution: Canada Cancer and Aging Research Laboratories
country: Canada
name: Canada Cancer and Aging Research Laboratories , Lethbridge, AB T1K7X8, Canada
last_name: Aliper
first_name: Alexander
name: Alexander Aliper
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 5
institution: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology
country: Russia
name: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow, 117198, Russia
last_name: Ilnitskaya
first_name: Elena
name: Elena Ilnitskaya
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
last_name: Sorokin
first_name: Maxim
name: Maxim Sorokin
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 2
institution: National Research Centre “Kurchatov Institute”
country: Russia
name: National Research Centre “Kurchatov Institute” , Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, 1, Akademika Kurchatova sq., Moscow, 123182, Russia
last_name: Korzinkin
first_name: Mihkail
name: Mihkail Korzinkin
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 3
institution: Pathway Pharmaceuticals
name: Pathway Pharmaceuticals , Wan Chai, Hong Kong, Hong Kong SAR
last_name: Saenko
first_name: Vyacheslav
name: Vyacheslav Saenko
affiliations: label: 8
institution: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University
country: Russia
name: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University , Leo Tolstoy str. 42, Ulyanovsk, 432000, Russia
last_name: Saenko
first_name: Yury
name: Yury Saenko
affiliations: label: 8
institution: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University
country: Russia
name: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University , Leo Tolstoy str. 42, Ulyanovsk, 432000, Russia
last_name: Sokov
first_name: Dmitry G.
name: Dmitry G. Sokov
affiliations: label: 9
institution: Moscow 1st Oncological Hospital
country: Russia
name: Moscow 1st Oncological Hospital , 17/1 Baumanskaya str., Moscow 105005, Russia
last_name: Gaifullin
first_name: Nurshat M.
name: Nurshat M. Gaifullin
affiliations: label: 10
institution: Lomonosov Moscow State University, Faculty of Fundamental Medicine
country: Russia
name: 10 Lomonosov Moscow State University, Faculty of Fundamental Medicine , Lomonosovsky Dr.,31-5, Moscow 119192, Russia
label: 11
institution: Russian medical postgraduate academy
country: Russia
name: 11 Russian medical postgraduate academy , Barrikadnaya str.,2/1, Moscow, 123995, Russia
last_name: Kashintsev
first_name: Kirill
name: Kirill Kashintsev
affiliations: label: 12
institution: Moscow Oncological Hospital 62
country: Russia
name: 12 Moscow Oncological Hospital 62 , Istra 27, Stepanovskoye, Krasnogorsk region, 143423, Russia
last_name: Shirokorad
first_name: Valery
name: Valery Shirokorad
affiliations: label: 12
institution: Moscow Oncological Hospital 62
country: Russia
name: 12 Moscow Oncological Hospital 62 , Istra 27, Stepanovskoye, Krasnogorsk region, 143423, Russia
last_name: Shabalina
first_name: Irina
name: Irina Shabalina
affiliations: label: 13
institution: Petrozavodsk State University, Faculty of Mathematics and Information Technologies
country: Russia
name: 13 Petrozavodsk State University, Faculty of Mathematics and Information Technologies , Anohina str., 20, Petrozavodsk 185910, Russia
last_name: Zhavoronkov
first_name: Alex
name: Alex Zhavoronkov
affiliations: label: 14
institution: Insilico Medicine, Inc, ETC, Johns Hopkins University
country: USA
name: 14 Insilico Medicine, Inc, ETC, Johns Hopkins University , Baltimore, MD, 21218, USA
last_name: Mishra
first_name: Bhubaneswar
name: Bhubaneswar Mishra
affiliations: label: 15
institution: Courant Institute, New York University
country: USA
name: 15 Courant Institute, New York University , NY, 10012, USA
last_name: Cantor
first_name: Charles R.
name: Charles R. Cantor
affiliations: label: 16
institution: Department of Biomedical Engineering
country: United States of America
name: 16 Department of Biomedical Engineering , Boston University, Boston, Massachusetts, United States of America
last_name: Buzdin
first_name: Anton
name: Anton Buzdin
affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 2
institution: National Research Centre “Kurchatov Institute”
country: Russia
name: National Research Centre “Kurchatov Institute” , Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, 1, Akademika Kurchatova sq., Moscow, 123182, Russia
label: 3
institution: Pathway Pharmaceuticals
name: Pathway Pharmaceuticals , Wan Chai, Hong Kong, Hong Kong SAR
label: 4
institution: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
country: Russia
name: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow, 117997, Russia
Affiliations: label: 1
institution: First Oncology Research and Advisory Center
country: Russia
name: First Oncology Research and Advisory Center , Moscow, 117997, Russia
label: 2
institution: National Research Centre “Kurchatov Institute”
country: Russia
name: National Research Centre “Kurchatov Institute” , Centre for Convergence of Nano-, Bio-, Information and Cognitive Sciences and Technologies, 1, Akademika Kurchatova sq., Moscow, 123182, Russia
label: 3
institution: Pathway Pharmaceuticals
name: Pathway Pharmaceuticals , Wan Chai, Hong Kong, Hong Kong SAR
label: 4
institution: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
country: Russia
name: Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry , Moscow, 117997, Russia
label: 5
institution: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology
country: Russia
name: Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and Immunology , Moscow, 117198, Russia
label: 6
institution: Department of Biological Sciences, University of Lethbridge
name: Department of Biological Sciences, University of Lethbridge , 4401 University Drive, Lethbridge, AB, T1K 3M4, Tel: 1-403-394-3916
label: 7
institution: Canada Cancer and Aging Research Laboratories
country: Canada
name: Canada Cancer and Aging Research Laboratories , Lethbridge, AB T1K7X8, Canada
label: 8
institution: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University
country: Russia
name: Technological Research Institute S.P. Kapitsa, Ulyanovsk State University , Leo Tolstoy str. 42, Ulyanovsk, 432000, Russia
label: 9
institution: Moscow 1st Oncological Hospital
country: Russia
name: Moscow 1st Oncological Hospital , 17/1 Baumanskaya str., Moscow 105005, Russia
label: 10
institution: Lomonosov Moscow State University, Faculty of Fundamental Medicine
country: Russia
name: 10 Lomonosov Moscow State University, Faculty of Fundamental Medicine , Lomonosovsky Dr.,31-5, Moscow 119192, Russia
label: 11
institution: Russian medical postgraduate academy
country: Russia
name: 11 Russian medical postgraduate academy , Barrikadnaya str.,2/1, Moscow, 123995, Russia
label: 12
institution: Moscow Oncological Hospital 62
country: Russia
name: 12 Moscow Oncological Hospital 62 , Istra 27, Stepanovskoye, Krasnogorsk region, 143423, Russia
label: 13
institution: Petrozavodsk State University, Faculty of Mathematics and Information Technologies
country: Russia
name: 13 Petrozavodsk State University, Faculty of Mathematics and Information Technologies , Anohina str., 20, Petrozavodsk 185910, Russia
label: 14
institution: Insilico Medicine, Inc, ETC, Johns Hopkins University
country: USA
name: 14 Insilico Medicine, Inc, ETC, Johns Hopkins University , Baltimore, MD, 21218, USA
label: 15
institution: Courant Institute, New York University
country: USA
name: 15 Courant Institute, New York University , NY, 10012, USA
label: 16
institution: Department of Biomedical Engineering
country: United States of America
name: 16 Department of Biomedical Engineering , Boston University, Boston, Massachusetts, United States of America
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2016