Title: The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells
Authors: orcid: http://orcid.org/0000-0002-9428-0060
last_name: Fanning
first_name: Sean W.
name: Sean W. Fanning
corresponding: yes
affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
last_name: Jeselsohn
first_name: Rinath
name: Rinath Jeselsohn
affiliations: label: 2
institution: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
country: USA
name: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute , Boston, MA 02215 USA
label: 3
institution: Department of Medical Oncology, Dana Farber Cancer Institute
country: USA
name: Department of Medical Oncology, Dana Farber Cancer Institute , Boston, MA 02215 USA
last_name: Dharmarajan
first_name: Venkatasubramanian
name: Venkatasubramanian Dharmarajan
affiliations: label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
orcid: http://orcid.org/0000-0001-8905-6569
last_name: Mayne
first_name: Christopher G.
name: Christopher G. Mayne
affiliations: label: 5
institution: Department of Chemistry, University of Illinois at Urbana-Champaign
country: USA
name: Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
label: 6
institution: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
country: USA
name: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
last_name: Karimi
first_name: Mostafa
name: Mostafa Karimi
affiliations: label: 7
institution: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
country: USA
name: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University , College Station, TX 77843 USA
last_name: Buchwalter
first_name: Gilles
name: Gilles Buchwalter
affiliations: label: 2
institution: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
country: USA
name: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute , Boston, MA 02215 USA
last_name: Houtman
first_name: Rene
name: Rene Houtman
affiliations: label: 8
institution: PamGene International B.V
country: Netherlands
name: PamGene International B.V , ‘s-Hertogenbosch, Netherlands 5211
last_name: Toy
first_name: Weiyi
name: Weiyi Toy
affiliations: label: 9
institution: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC)
country: USA
name: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC) , New York, NY 10065, USA
last_name: Fowler
first_name: Colin E.
name: Colin E. Fowler
affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
last_name: Lainé
first_name: Muriel
name: Muriel Lainé
affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
last_name: Carlson
first_name: Kathryn E
name: Kathryn E Carlson
affiliations: label: 5
institution: Department of Chemistry, University of Illinois at Urbana-Champaign
country: USA
name: Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
last_name: Martin
first_name: Teresa A.
name: Teresa A. Martin
affiliations: label: 5
institution: Department of Chemistry, University of Illinois at Urbana-Champaign
country: USA
name: Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
last_name: Nowak
first_name: Jason
name: Jason Nowak
affiliations: label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
orcid: http://orcid.org/0000-0003-4313-9187
last_name: Nwachukwu
first_name: Jerome
name: Jerome Nwachukwu
affiliations: label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
last_name: Hosfield
first_name: David J.
name: David J. Hosfield
affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
orcid: http://orcid.org/0000-0003-4532-8053
last_name: Chandarlapaty
first_name: Sarat
name: Sarat Chandarlapaty
affiliations: label: 9
institution: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC)
country: USA
name: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC) , New York, NY 10065, USA
orcid: http://orcid.org/0000-0001-8434-1010
last_name: Tajkhorshid
first_name: Emad
name: Emad Tajkhorshid
affiliations: label: 6
institution: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
country: USA
name: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
last_name: Nettles
first_name: Kendall W.
name: Kendall W. Nettles
affiliations: label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
last_name: Griffin
first_name: Patrick R.
name: Patrick R. Griffin
affiliations: label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
last_name: Shen
first_name: Yang
name: Yang Shen
affiliations: label: 7
institution: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
country: USA
name: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University , College Station, TX 77843 USA
last_name: Katzenellenbogen
first_name: John A.
name: John A. Katzenellenbogen
affiliations: label: 5
institution: Department of Chemistry, University of Illinois at Urbana-Champaign
country: USA
name: Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
orcid: http://orcid.org/0000-0002-8213-1658
last_name: Brown
first_name: Myles
name: Myles Brown
affiliations: label: 2
institution: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
country: USA
name: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute , Boston, MA 02215 USA
label: 3
institution: Department of Medical Oncology, Dana Farber Cancer Institute
country: USA
name: Department of Medical Oncology, Dana Farber Cancer Institute , Boston, MA 02215 USA
orcid: http://orcid.org/0000-0001-6894-8728
last_name: Greene
first_name: Geoffrey L.
name: Geoffrey L. Greene
affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
Affiliations: label: 1
institution: Ben May Department for Cancer Research, University of Chicago
country: USA
name: Ben May Department for Cancer Research, University of Chicago , Chicago, IL 60637 USA
label: 2
institution: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
country: USA
name: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute , Boston, MA 02215 USA
label: 3
institution: Department of Medical Oncology, Dana Farber Cancer Institute
country: USA
name: Department of Medical Oncology, Dana Farber Cancer Institute , Boston, MA 02215 USA
label: 4
institution: Department of Molecular Medicine, The Scripps Research Institute
country: USA
name: Department of Molecular Medicine, The Scripps Research Institute , Jupiter, FL 33458, USA
label: 5
institution: Department of Chemistry, University of Illinois at Urbana-Champaign
country: USA
name: Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
label: 6
institution: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
country: USA
name: Department of Biochemistry, College of Medicine, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign , Urbana, IL 61801 USA
label: 7
institution: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University
country: USA
name: Department of Electrical and Computer Engineering, TEES-AgriLife Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University , College Station, TX 77843 USA
label: 8
institution: PamGene International B.V
country: Netherlands
name: PamGene International B.V , ‘s-Hertogenbosch, Netherlands 5211
label: 9
institution: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC)
country: USA
name: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center (MSKCC) , New York, NY 10065, USA
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2018