Title: Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer’s disease
Authors: last_name: Rathore
first_name: Nisha
name: Nisha Rathore
affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
last_name: Ramani
first_name: Sree Ranjani
name: Sree Ranjani Ramani
affiliations: label: 2
institution: Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc.
name: Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc. , South San Francisco CA 94080
last_name: Pantua
first_name: Homer
name: Homer Pantua
affiliations: label: 3
institution: Department of Immunology and Infectious Diseases, Genentech Inc.
name: Department of Immunology and Infectious Diseases, Genentech Inc. , South San Francisco CA 94080
last_name: Payandeh
first_name: Jian
name: Jian Payandeh
affiliations: label: 4
institution: Department of Structural Biology, Genentech Inc.
name: Department of Structural Biology, Genentech Inc. , South San Francisco CA 94080
orcid: http://orcid.org/0000-0002-8233-9977
last_name: Bhangale
first_name: Tushar
name: Tushar Bhangale
affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
label: 9
institution: Department of Bioinformatics and Computational Biology, Genentech Inc.
name: Department of Bioinformatics and Computational Biology, Genentech Inc. , South San Francisco CA 94080
last_name: Wuster
first_name: Arthur
name: Arthur Wuster
affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
label: 9
institution: Department of Bioinformatics and Computational Biology, Genentech Inc.
name: Department of Bioinformatics and Computational Biology, Genentech Inc. , South San Francisco CA 94080
last_name: Kapoor
first_name: Manav
name: Manav Kapoor
affiliations: label: 5
institution: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai
name: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai , 1425 Madison Ave, New York, NY 10029
last_name: Sun
first_name: Yonglian
name: Yonglian Sun
affiliations: label: 6
institution: Department of Immunology, Genentech Inc.
name: Department of Immunology, Genentech Inc. , South San Francisco CA 94080
notes: Current affiliation: Department of Antibody engineering, Genentech Inc., South San Francisco, CA 94080
last_name: Kapadia
first_name: Sharookh
name: Sharookh Kapadia
affiliations: label: 3
institution: Department of Immunology and Infectious Diseases, Genentech Inc.
name: Department of Immunology and Infectious Diseases, Genentech Inc. , South San Francisco CA 94080
last_name: Gonzalez
first_name: Lino
name: Lino Gonzalez
affiliations: label: 7
institution: Department of Proteomics & Biological Resources, Genentech Inc.
name: Department of Proteomics & Biological Resources, Genentech Inc. , South San Francisco CA 94080. Current affiliation: Therapeutics, 23 and Me, South San Francisco, CA 94080
last_name: Zarrin
first_name: Ali A.
name: Ali A. Zarrin
affiliations: label: 6
institution: Department of Immunology, Genentech Inc.
name: Department of Immunology, Genentech Inc. , South San Francisco CA 94080
last_name: Goate
first_name: Alison
name: Alison Goate
affiliations: label: 5
institution: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai
name: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai , 1425 Madison Ave, New York, NY 10029
orcid: http://orcid.org/0000-0001-9679-7189
last_name: Hansen
first_name: David
name: David Hansen
affiliations: label: 8
institution: Department of Neuroscience, Genentech Inc.
name: Department of Neuroscience, Genentech Inc. , South San Francisco CA 94080
last_name: Behrens
first_name: Timothy W.
name: Timothy W. Behrens
corresponding: yes
affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
orcid: http://orcid.org/0000-0001-7151-4277
last_name: Graham
first_name: Robert R.
name: Robert R. Graham
corresponding: yes
affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
Affiliations: label: 1
institution: Department of OMNI Human Genetics, Genentech Inc.
name: Department of OMNI Human Genetics, Genentech Inc. , South San Francisco CA 94080
label: 2
institution: Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc.
name: Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc. , South San Francisco CA 94080
label: 3
institution: Department of Immunology and Infectious Diseases, Genentech Inc.
name: Department of Immunology and Infectious Diseases, Genentech Inc. , South San Francisco CA 94080
label: 4
institution: Department of Structural Biology, Genentech Inc.
name: Department of Structural Biology, Genentech Inc. , South San Francisco CA 94080
label: 5
institution: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai
name: Ronald M. Loeb Center for Alzheimer’s disease, B1065, Icahn School of Medicine at Mount Sinai , 1425 Madison Ave, New York, NY 10029
label: 6
institution: Department of Immunology, Genentech Inc.
name: Department of Immunology, Genentech Inc. , South San Francisco CA 94080
label: 7
institution: Department of Proteomics & Biological Resources, Genentech Inc.
name: Department of Proteomics & Biological Resources, Genentech Inc. , South San Francisco CA 94080. Current affiliation: Therapeutics, 23 and Me, South San Francisco, CA 94080
label: 8
institution: Department of Neuroscience, Genentech Inc.
name: Department of Neuroscience, Genentech Inc. , South San Francisco CA 94080
label: 9
institution: Department of Bioinformatics and Computational Biology, Genentech Inc.
name: Department of Bioinformatics and Computational Biology, Genentech Inc. , South San Francisco CA 94080
Field: Neuroscience
Document type: preprint
Year: 2018