Title: Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Authors: orcid: http://orcid.org/0000-0003-3313-3857
last_name: Pettitt
first_name: Stephen J.
name: Stephen J. Pettitt
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
notes: Equal contribution (SJP and DBK)
last_name: Krastev
first_name: Dragomir B.
name: Dragomir B. Krastev
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
notes: Equal contribution (SJP and DBK)
last_name: Brandsma
first_name: Inger
name: Inger Brandsma
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Drean
first_name: Amy
name: Amy Drean
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Song
first_name: Feifei
name: Feifei Song
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Aleksandrov
first_name: Radoslav
name: Radoslav Aleksandrov
affiliations: label: 5
institution: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences
name: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences , Sofia 1113, Bulgaria
last_name: Harrell
first_name: Maria I.
name: Maria I. Harrell
affiliations: label: 6
institution: University of Washington School of Medicine
country: USA
name: University of Washington School of Medicine . 1959 NE Pacific St, Seattle, WA 98195, USA
last_name: Menon
first_name: Malini
name: Malini Menon
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Brough
first_name: Rachel
name: Rachel Brough
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Campbell
first_name: James
name: James Campbell
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Frankum
first_name: Jessica
name: Jessica Frankum
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Ranes
first_name: Michael
name: Michael Ranes
affiliations: label: 4
institution: Divison of Structural Biology, The Institute of Cancer Research
country: UK
name: Divison of Structural Biology, The Institute of Cancer Research , London, SW3 6JB, UK .
last_name: Pemberton
first_name: Helen N.
name: Helen N. Pemberton
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Rafiq
first_name: Rumana
name: Rumana Rafiq
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
last_name: Fenwick
first_name: Kerry
name: Kerry Fenwick
affiliations: label: 3
institution: Tumour Profiling Unit, The Institute of Cancer Research
country: UK
name: Tumour Profiling Unit, The Institute of Cancer Research , London, SW3 6JB, UK .
last_name: Swain
first_name: Amanda
name: Amanda Swain
affiliations: label: 3
institution: Tumour Profiling Unit, The Institute of Cancer Research
country: UK
name: Tumour Profiling Unit, The Institute of Cancer Research , London, SW3 6JB, UK .
last_name: Guettler
first_name: Sebastian
name: Sebastian Guettler
affiliations: label: 4
institution: Divison of Structural Biology, The Institute of Cancer Research
country: UK
name: Divison of Structural Biology, The Institute of Cancer Research , London, SW3 6JB, UK .
last_name: Lee
first_name: Jung-Min
name: Jung-Min Lee
affiliations: label: 7
institution: Center for Cancer Research, National Cancer Institute
country: USA
name: Center for Cancer Research, National Cancer Institute , Bethesda, MD 20892, USA .
last_name: Swisher
first_name: Elizabeth M.
name: Elizabeth M. Swisher
affiliations: label: 6
institution: University of Washington School of Medicine
country: USA
name: University of Washington School of Medicine . 1959 NE Pacific St, Seattle, WA 98195, USA
last_name: Stoynov
first_name: Stoyno
name: Stoyno Stoynov
affiliations: label: 5
institution: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences
name: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences , Sofia 1113, Bulgaria
last_name: Yusa
first_name: Kosuke
name: Kosuke Yusa
affiliations: label: 8
institution: Wellcome Trust Sanger Institute, Hinxton
country: UK
name: Wellcome Trust Sanger Institute, Hinxton , Cambridgeshire, CB10 1SA, UK
last_name: Ashworth
first_name: Alan
name: Alan Ashworth
corresponding: yes
notes: Current address: UCSF Helen Diller Family Comprehensive Cancer Center, 1450 3rd St, San Francisco, CA 94158, USA
last_name: Lord
first_name: Christopher J.
name: Christopher J. Lord
corresponding: yes
affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
Affiliations: label: 1
institution: The CRUK Gene Function Laboratory
country: UK
name: The CRUK Gene Function Laboratory , London, SW3 6JB, UK .
label: 2
institution: Breast Cancer Now Toby Robins Research Centre
country: UK
name: Breast Cancer Now Toby Robins Research Centre , London, SW3 6JB, UK .
label: 3
institution: Tumour Profiling Unit, The Institute of Cancer Research
country: UK
name: Tumour Profiling Unit, The Institute of Cancer Research , London, SW3 6JB, UK .
label: 4
institution: Divison of Structural Biology, The Institute of Cancer Research
country: UK
name: Divison of Structural Biology, The Institute of Cancer Research , London, SW3 6JB, UK .
label: 5
institution: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences
name: Institute of Molecular Biology ‘Roumen Tsanev’, Bulgarian Academy of Sciences , Sofia 1113, Bulgaria
label: 6
institution: University of Washington School of Medicine
country: USA
name: University of Washington School of Medicine . 1959 NE Pacific St, Seattle, WA 98195, USA
label: 7
institution: Center for Cancer Research, National Cancer Institute
country: USA
name: Center for Cancer Research, National Cancer Institute , Bethesda, MD 20892, USA .
label: 8
institution: Wellcome Trust Sanger Institute, Hinxton
country: UK
name: Wellcome Trust Sanger Institute, Hinxton , Cambridgeshire, CB10 1SA, UK
Field: Medicine
Document type: preprint
Year: 2017