Title: The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
Authors: last_name: Martin-Loeches
first_name: Ignacio
name: Ignacio Martin-Loeches
affiliations: label: 1
institution: Multidisciplinary Intensive Care research organization (MICRO), St. James’s University Hospitals Dublin
country: Ireland
name: Multidisciplinary Intensive Care research organization (MICRO), St. James’s University Hospitals Dublin . James’s St, Ushers, Dublin 8, Ireland
last_name: Muriel-Bombín
first_name: Arturo
name: Arturo Muriel-Bombín
affiliations: label: 2
institution: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid
country: Spain
name: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid , Calle Dulzaina, 2. 47012 Valladolid, Spain ,
last_name: Ferrer
first_name: Ricard
name: Ricard Ferrer
affiliations: label: 3
institution: Intensive Care Department, Vall d’Hebron University Hospital. Shock, Organ Dysfunction and Resuscitation Research Group. Vall d’ Hebron Research Institute
country: Spain
name: Intensive Care Department, Vall d’Hebron University Hospital. Shock, Organ Dysfunction and Resuscitation Research Group. Vall d’ Hebron Research Institute . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
last_name: Artigas
first_name: Antonio
name: Antonio Artigas
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 5
institution: Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli
country: Spain
name: Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli , Autonomous University of Barcelona, Parc Taulí, 1, 08208 Sabadell, Barcelona, Spain
label: 6
institution: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III
country: Spain
name: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III , C/ Sinesio Delgado, 4, 28029 - Madrid, Spain
last_name: Sole-Violan
first_name: Jordi
name: Jordi Sole-Violan
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 7
institution: Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena
country: Spain
name: Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena , s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain
last_name: Lorente
first_name: Leonardo
name: Leonardo Lorente
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 8
institution: Critical Care Medicine Service, Hospital Universitario de Canarias
country: Spain
name: Critical Care Medicine Service, Hospital Universitario de Canarias , Carretera de Ofra, s/n, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
last_name: Andaluz-Ojeda
first_name: David
name: David Andaluz-Ojeda
affiliations: label: 9
institution: Critical Care Medicine Service. Hospital Clínico Universitario de Valladolid
country: Spain
name: Critical Care Medicine Service. Hospital Clínico Universitario de Valladolid , Av. Ramón y Cajal, 3, 47003, Valladolid Spain
last_name: Prina-Mello
first_name: Adriele
name: Adriele Prina-Mello
affiliations: label: 10
institution: Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI)
country: Ireland
name: 10 Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI) , James’s St, Dublin 8, Ireland
last_name: Herrán-Monge
first_name: Ruben
name: Ruben Herrán-Monge
affiliations: label: 2
institution: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid
country: Spain
name: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid , Calle Dulzaina, 2. 47012 Valladolid, Spain ,
last_name: Suberviola
first_name: Borja
name: Borja Suberviola
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 11
institution: Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008 Santander
country: Spain
name: 11 Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008 Santander , Spain
last_name: Rodriguez-Fernandez
first_name: Ana
name: Ana Rodriguez-Fernandez
affiliations: label: 12
institution: Microbiology Service, Hospital Marques de Valdecilla
country: Spain
name: 12 Microbiology Service, Hospital Marques de Valdecilla , Av. Valdecilla, 25, 39008 Santander, Spain
last_name: Merino
first_name: Pedro
name: Pedro Merino
affiliations: label: 2
institution: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid
country: Spain
name: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid , Calle Dulzaina, 2. 47012 Valladolid, Spain ,
last_name: Loza
first_name: Ana M
name: Ana M Loza
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 13
institution: Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista
country: Spain
name: 13 Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista , s/n, 41014 Sevilla, Spain
last_name: Garcia-Olivares
first_name: Pablo
name: Pablo Garcia-Olivares
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 14
institution: Critical Care Medicine Service, Hospital General Universitario Gregorio
country: Spain
name: 14 Critical Care Medicine Service, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain
last_name: Anton
first_name: Eduardo
name: Eduardo Anton
affiliations: label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 15
institution: Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia
country: Spain
name: 15 Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia , s/n, 07500 Manacor, Spain
last_name: Tamayo
first_name: Eduardo
name: Eduardo Tamayo
affiliations: label: 16
institution: Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal
country: Spain
name: 16 Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal , 3, 47003, Valladolid Spain
last_name: Trapiello
first_name: Wysali
name: Wysali Trapiello
affiliations: label: 17
institution: BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario
country: Spain
name: 17 BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario , SACYL, Av. Ramón y Cajal, 3, 47003, Valladolid Spain
last_name: Blanco
first_name: Jesús
name: Jesús Blanco
corresponding: yes
affiliations: label: 2
institution: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid
country: Spain
name: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid , Calle Dulzaina, 2. 47012 Valladolid, Spain ,
label: 6
institution: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III
country: Spain
name: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III , C/ Sinesio Delgado, 4, 28029 - Madrid, Spain
last_name: Bermejo-Martin
first_name: Jesús F
name: Jesús F Bermejo-Martin
affiliations: label: 17
institution: BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario
country: Spain
name: 17 BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario , SACYL, Av. Ramón y Cajal, 3, 47003, Valladolid Spain
affiliations: label: 18
name: 18 GRECIA group (Grupo de Estudios y Análisis en Cuidados Intensivos). Critical Care Medicine Service, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2. 47012 Valladolid, Spain
Affiliations: label: 1
institution: Multidisciplinary Intensive Care research organization (MICRO), St. James’s University Hospitals Dublin
country: Ireland
name: Multidisciplinary Intensive Care research organization (MICRO), St. James’s University Hospitals Dublin . James’s St, Ushers, Dublin 8, Ireland
label: 2
institution: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid
country: Spain
name: Intensive Care Department, Hospital Universitario Río Hortega de Valladolid , Calle Dulzaina, 2. 47012 Valladolid, Spain ,
label: 3
institution: Intensive Care Department, Vall d’Hebron University Hospital. Shock, Organ Dysfunction and Resuscitation Research Group. Vall d’ Hebron Research Institute
country: Spain
name: Intensive Care Department, Vall d’Hebron University Hospital. Shock, Organ Dysfunction and Resuscitation Research Group. Vall d’ Hebron Research Institute . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 4
institution: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital
country: Spain
name: ABISS-Edusepsis (AntiBiotic Intervention in Severe Sepsis). Intensive Care Department, Vall d’Hebron University Hospital . Passeig de la Vall d’Hebron, 119-129, 08035 Barcelona, Spain
label: 5
institution: Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli
country: Spain
name: Critical Care Center, Corporacion Sanitaria Universitaria Parc Tauli , Autonomous University of Barcelona, Parc Taulí, 1, 08208 Sabadell, Barcelona, Spain
label: 6
institution: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III
country: Spain
name: CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III , C/ Sinesio Delgado, 4, 28029 - Madrid, Spain
label: 7
institution: Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena
country: Spain
name: Critical Care Medicine Service, Hospital Dr Negrin, Barranco de la Ballena , s/n, 35010 Las Palmas de Gran Canaria, Las Palmas, Spain
label: 8
institution: Critical Care Medicine Service, Hospital Universitario de Canarias
country: Spain
name: Critical Care Medicine Service, Hospital Universitario de Canarias , Carretera de Ofra, s/n, 38320 San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain
label: 9
institution: Critical Care Medicine Service. Hospital Clínico Universitario de Valladolid
country: Spain
name: Critical Care Medicine Service. Hospital Clínico Universitario de Valladolid , Av. Ramón y Cajal, 3, 47003, Valladolid Spain
label: 10
institution: Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI)
country: Ireland
name: 10 Laboratory for Biological Characterisation of Advanced Materials, Trinity Translational Medicine Institute (TTMI) , James’s St, Dublin 8, Ireland
label: 11
institution: Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008 Santander
country: Spain
name: 11 Critical Care Medicine Service, Hospital Universitario Marqués de Valdecilla, Av. Valdecilla, 25, 39008 Santander , Spain
label: 12
institution: Microbiology Service, Hospital Marques de Valdecilla
country: Spain
name: 12 Microbiology Service, Hospital Marques de Valdecilla , Av. Valdecilla, 25, 39008 Santander, Spain
label: 13
institution: Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista
country: Spain
name: 13 Critical Care Medicine Service, Hospital Nuestra Señora de Valme, Av. de Bellavista , s/n, 41014 Sevilla, Spain
label: 14
institution: Critical Care Medicine Service, Hospital General Universitario Gregorio
country: Spain
name: 14 Critical Care Medicine Service, Hospital General Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain
label: 15
institution: Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia
country: Spain
name: 15 Critical Care Medicine Service, Hospital de Manacor, Carretera Manacor Alcudia , s/n, 07500 Manacor, Spain
label: 16
institution: Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal
country: Spain
name: 16 Anesthesiology Service, Hospital Clínico Universitario de Valladolid, Av. Ramón y Cajal , 3, 47003, Valladolid Spain
label: 17
institution: BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario
country: Spain
name: 17 BIOSEPSIS (Laboratory of Biomedical Research in Sepsis) Hospital Clínico Universitario , SACYL, Av. Ramón y Cajal, 3, 47003, Valladolid Spain
label: 18
name: 18 GRECIA group (Grupo de Estudios y Análisis en Cuidados Intensivos). Critical Care Medicine Service, Hospital Universitario Río Hortega de Valladolid, Calle Dulzaina, 2. 47012 Valladolid, Spain
Field: Medicine
Document type: preprint
Year: 2017