Title: Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
Authors: orcid: http://orcid.org/0000-0002-3738-5907
last_name: Berger
first_name: Stephanie
name: Stephanie Berger
corresponding: yes
affiliations: label: 1
address: Seattle
institution: Department of Bioengineering
country: United States
name: Department of Bioengineering , University of Washington , Seattle , United States
last_name: Procko
first_name: Erik
name: Erik Procko
affiliations: label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
label: 3
address: Urbana
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Illinois , Urbana , United States
last_name: Margineantu
first_name: Daciana
name: Daciana Margineantu
affiliations: label: 4
address: Seattle
institution: Clinical Research Division
country: United States
name: Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 5
address: Seattle
institution: Human Biology Division
country: United States
name: Human Biology Division , Fred Hutchinson Cancer Research Center , Seattle , United States
last_name: Lee
first_name: Erinna F
name: Erinna F Lee
affiliations: label: 6
address: Melbourne
institution: Department of Chemistry and Physics
country: Australia
name: Department of Chemistry and Physics , LaTrobe Institute for Molecular Science , Melbourne , Australia
label: 7
address: Heidelberg
institution: Olivia Newton-John Cancer Research Institute
country: Australia
name: Olivia Newton-John Cancer Research Institute , Olivia Newton-John Cancer and Wellness Centre , Heidelberg , Australia
label: 8
address: Melbourne
institution: School of Cancer Medicine
country: Australia
name: School of Cancer Medicine , La Trobe University , Melbourne , Australia
label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
last_name: Shen
first_name: Betty W
name: Betty W Shen
affiliations: label: 11
address: Seattle
institution: Basic Sciences Division
country: United States
name: 11 Basic Sciences Division , Fred Hutchinson Cancer Research Center , Seattle , United States
last_name: Zelter
first_name: Alex
name: Alex Zelter
affiliations: label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
last_name: Silva
first_name: Daniel-Adriano
name: Daniel-Adriano Silva
affiliations: label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
label: 12
address: Seattle
institution: Institute for Protein Design
country: United States
name: 12 Institute for Protein Design , University of Washington , Seattle , United States
last_name: Chawla
first_name: Kusum
name: Kusum Chawla
affiliations: label: 4
address: Seattle
institution: Clinical Research Division
country: United States
name: Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 5
address: Seattle
institution: Human Biology Division
country: United States
name: Human Biology Division , Fred Hutchinson Cancer Research Center , Seattle , United States
last_name: Herold
first_name: Marco J
name: Marco J Herold
affiliations: label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
last_name: Garnier
first_name: Jean-Marc
name: Jean-Marc Garnier
affiliations: label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
last_name: Johnson
first_name: Richard
name: Richard Johnson
affiliations: label: 13
address: Seattle
institution: Department of Genome Sciences
country: United States
name: 13 Department of Genome Sciences , University of Washington , Seattle , United States
last_name: MacCoss
first_name: Michael J
name: Michael J MacCoss
affiliations: label: 13
address: Seattle
institution: Department of Genome Sciences
country: United States
name: 13 Department of Genome Sciences , University of Washington , Seattle , United States
orcid: http://orcid.org/0000-0002-1193-8147
last_name: Lessene
first_name: Guillaume
name: Guillaume Lessene
affiliations: label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
label: 14
address: Parkville
institution: Department of Pharmacology and Therapeutics
country: Australia
name: 14 Department of Pharmacology and Therapeutics , University of Melbourne , Parkville , Australia
orcid: http://orcid.org/0000-0003-4797-3152
last_name: Davis
first_name: Trisha N
name: Trisha N Davis
affiliations: label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
last_name: Stayton
first_name: Patrick S
name: Patrick S Stayton
affiliations: label: 1
address: Seattle
institution: Department of Bioengineering
country: United States
name: Department of Bioengineering , University of Washington , Seattle , United States
last_name: Stoddard
first_name: Barry L
name: Barry L Stoddard
affiliations: label: 11
address: Seattle
institution: Basic Sciences Division
country: United States
name: 11 Basic Sciences Division , Fred Hutchinson Cancer Research Center , Seattle , United States
last_name: Fairlie
first_name: W Douglas
name: W Douglas Fairlie
affiliations: label: 6
address: Melbourne
institution: Department of Chemistry and Physics
country: Australia
name: Department of Chemistry and Physics , LaTrobe Institute for Molecular Science , Melbourne , Australia
label: 7
address: Heidelberg
institution: Olivia Newton-John Cancer Research Institute
country: Australia
name: Olivia Newton-John Cancer Research Institute , Olivia Newton-John Cancer and Wellness Centre , Heidelberg , Australia
label: 8
address: Melbourne
institution: School of Cancer Medicine
country: Australia
name: School of Cancer Medicine , La Trobe University , Melbourne , Australia
label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
last_name: Hockenbery
first_name: David M
name: David M Hockenbery
affiliations: label: 4
address: Seattle
institution: Clinical Research Division
country: United States
name: Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 5
address: Seattle
institution: Human Biology Division
country: United States
name: Human Biology Division , Fred Hutchinson Cancer Research Center , Seattle , United States
orcid: http://orcid.org/0000-0001-7896-6217
last_name: Baker
first_name: David
name: David Baker
corresponding: yes
affiliations: label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
label: 12
address: Seattle
institution: Institute for Protein Design
country: United States
name: 12 Institute for Protein Design , University of Washington , Seattle , United States
label: 15
address: Seattle
institution: Howard Hughes Medical Institute
country: United States
name: 15 Howard Hughes Medical Institute , University of Washington , Seattle , United States
Affiliations: label: 1
address: Seattle
institution: Department of Bioengineering
country: United States
name: Department of Bioengineering , University of Washington , Seattle , United States
label: 2
address: Seattle
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Washington , Seattle , United States
label: 3
address: Urbana
institution: Department of Biochemistry
country: United States
name: Department of Biochemistry , University of Illinois , Urbana , United States
label: 4
address: Seattle
institution: Clinical Research Division
country: United States
name: Clinical Research Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 5
address: Seattle
institution: Human Biology Division
country: United States
name: Human Biology Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 6
address: Melbourne
institution: Department of Chemistry and Physics
country: Australia
name: Department of Chemistry and Physics , LaTrobe Institute for Molecular Science , Melbourne , Australia
label: 7
address: Heidelberg
institution: Olivia Newton-John Cancer Research Institute
country: Australia
name: Olivia Newton-John Cancer Research Institute , Olivia Newton-John Cancer and Wellness Centre , Heidelberg , Australia
label: 8
address: Melbourne
institution: School of Cancer Medicine
country: Australia
name: School of Cancer Medicine , La Trobe University , Melbourne , Australia
label: 9
address: Parkville
institution: The Walter and Eliza Hall Institute of Medical Research
country: Australia
name: The Walter and Eliza Hall Institute of Medical Research , Parkville , Australia
label: 10
address: Parkville
institution: Department of Medical Biology
country: Australia
name: 10 Department of Medical Biology , University of Melbourne , Parkville , Australia
label: 11
address: Seattle
institution: Basic Sciences Division
country: United States
name: 11 Basic Sciences Division , Fred Hutchinson Cancer Research Center , Seattle , United States
label: 12
address: Seattle
institution: Institute for Protein Design
country: United States
name: 12 Institute for Protein Design , University of Washington , Seattle , United States
label: 13
address: Seattle
institution: Department of Genome Sciences
country: United States
name: 13 Department of Genome Sciences , University of Washington , Seattle , United States
label: 14
address: Parkville
institution: Department of Pharmacology and Therapeutics
country: Australia
name: 14 Department of Pharmacology and Therapeutics , University of Melbourne , Parkville , Australia
label: 15
address: Seattle
institution: Howard Hughes Medical Institute
country: United States
name: 15 Howard Hughes Medical Institute , University of Washington , Seattle , United States
institution: DE Shaw Research
country: United States
name: DE Shaw Research , United States
institution: DE Shaw Research
country: United States
name: DE Shaw Research , United States
Field: Biochemistry, Genetics and Molecular Biology
Document type: article
Year: 2016