Title: Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis
Authors: last_name: Meier
first_name: Stuart
name: Stuart Meier
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
last_name: Seddon
first_name: James A.
name: James A. Seddon
affiliations: label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
label: 5
address: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
name: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
label: 6
address: Department of Infectious Diseases, Imperial College London, London, United Kingdom
name: Department of Infectious Diseases, Imperial College London, London, United Kingdom
last_name: Maasdorp
first_name: Elizna
name: Elizna Maasdorp
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
label: 7
address: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
name: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
last_name: Kleynhans
first_name: Léanie
name: Léanie Kleynhans
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
last_name: du Plessis
first_name: Nelita
name: Nelita du Plessis
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
last_name: Loxton
first_name: Andre G.
name: Andre G. Loxton
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
last_name: Malherbe
first_name: Stephanus T.
name: Stephanus T. Malherbe
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
last_name: Zak
first_name: Daniel E.
name: Daniel E. Zak
affiliations: label: 8
address: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
name: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
last_name: Thompson
first_name: Ethan
name: Ethan Thompson
affiliations: label: 8
address: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
name: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
last_name: Duffy
first_name: Fergal J.
name: Fergal J. Duffy
affiliations: label: 8
address: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
name: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
last_name: Kaufmann
first_name: Stefan H. E.
name: Stefan H. E. Kaufmann
affiliations: label: 9
address: Max Planck Institute for Infection Biology, Berlin, Germany
name: Max Planck Institute for Infection Biology, Berlin, Germany
label: 10
address: Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
name: 10  Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
label: 11
address: Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, United States of America
name: 11  Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, United States of America
last_name: Ottenhoff
first_name: Tom H. M.
name: Tom H. M. Ottenhoff
affiliations: label: 12
address: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
name: 12  Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
last_name: Scriba
first_name: Thomas J.
name: Thomas J. Scriba
affiliations: label: 13
address: South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
name: 13  South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
orcid: https://orcid.org/0000-0002-5154-576X
last_name: Suliman
first_name: Sara
name: Sara Suliman
affiliations: label: 13
address: South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
name: 13  South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
last_name: Sutherland
first_name: Jayne S.
name: Jayne S. Sutherland
affiliations: label: 14
address: Vaccines & Immunity Theme, Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
name: 14  Vaccines & Immunity Theme, Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
last_name: Winter
first_name: Jill
name: Jill Winter
affiliations: label: 15
address: Catalysis Foundation for Health, San Ramon, CA, United States of America
name: 15  Catalysis Foundation for Health, San Ramon, CA, United States of America
orcid: https://orcid.org/0000-0001-5753-8766
last_name: Kuivaniemi
first_name: Helena
name: Helena Kuivaniemi
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
last_name: Walzl
first_name: Gerhard
name: Gerhard Walzl
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
orcid: https://orcid.org/0000-0002-7761-0806
last_name: Tromp
first_name: Gerard
name: Gerard Tromp
corresponding: yes
affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
label: 7
address: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
name: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
last_name: Mummidi
first_name: Srinivas
name: Srinivas Mummidi
last_name: Mummidi
first_name: Srinivas
name: Srinivas Mummidi
last_name: Mummidi
first_name: Srinivas
name: Srinivas Mummidi
Affiliations: label: 1
address: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
name: Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa
label: 2
address: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 3
address: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
name: South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa
label: 4
address: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
name: South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa
label: 5
address: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
name: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa
label: 6
address: Department of Infectious Diseases, Imperial College London, London, United Kingdom
name: Department of Infectious Diseases, Imperial College London, London, United Kingdom
label: 7
address: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
name: Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa
label: 8
address: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
name: Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America
label: 9
address: Max Planck Institute for Infection Biology, Berlin, Germany
name: Max Planck Institute for Infection Biology, Berlin, Germany
label: 10
address: Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
name: 10  Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany
label: 11
address: Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, United States of America
name: 11  Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, United States of America
label: 12
address: Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
name: 12  Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
label: 13
address: South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
name: 13  South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa
label: 14
address: Vaccines & Immunity Theme, Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
name: 14  Vaccines & Immunity Theme, Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
label: 15
address: Catalysis Foundation for Health, San Ramon, CA, United States of America
name: 15  Catalysis Foundation for Health, San Ramon, CA, United States of America
address: The University of Texas Rio Grande Valley, UNITED STATES
name: The University of Texas Rio Grande Valley, UNITED STATES
Field: Immunology and Microbiology
Document type: article
Year: 2022