Title: Trisomy 21 drives production of neurotoxic tryptophan catabolites via the interferon-inducible kynurenine pathway
Authors: last_name: Powers
first_name: Rani K.
name: Rani K. Powers
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 2
institution: Computational Bioscience Program, University of Colorado Anschutz Medical Campus
country: USA
name: Computational Bioscience Program, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 3
institution: Department of Pharmacology, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Pharmacology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
notes: These authors contributed equally to this work
orcid: http://orcid.org/0000-0003-2725-0205
last_name: Sullivan
first_name: Kelly D.
name: Kelly D. Sullivan
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 3
institution: Department of Pharmacology, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Pharmacology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
notes: These authors contributed equally to this work
last_name: Culp-Hill
first_name: Rachel
name: Rachel Culp-Hill
affiliations: label: 4
institution: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Ludwig
first_name: Michael P.
name: Michael P. Ludwig
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Smith
first_name: Keith P.
name: Keith P. Smith
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Waugh
first_name: Katherine A.
name: Katherine A. Waugh
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
orcid: http://orcid.org/0000-0002-5437-5911
last_name: Minter
first_name: Ross
name: Ross Minter
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
orcid: http://orcid.org/0000-0002-9285-5297
last_name: Tuttle
first_name: Kathryn D.
name: Kathryn D. Tuttle
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Rachubinski
first_name: Angela L.
name: Angela L. Rachubinski
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Granrath
first_name: Ross E.
name: Ross E. Granrath
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Wilkerson
first_name: Rebecca B.
name: Rebecca B. Wilkerson
affiliations: label: 4
institution: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: D’Alessandro
first_name: Angelo
name: Angelo D’Alessandro
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 4
institution: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
last_name: Costello
first_name: James C.
name: James C. Costello
corresponding: yes
affiliations: label: 2
institution: Computational Bioscience Program, University of Colorado Anschutz Medical Campus
country: USA
name: Computational Bioscience Program, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 3
institution: Department of Pharmacology, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Pharmacology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
orcid: http://orcid.org/0000-0001-9048-1941
last_name: Espinosa
first_name: Joaquin M.
name: Joaquin M. Espinosa
corresponding: yes
affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 3
institution: Department of Pharmacology, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Pharmacology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 5
institution: Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder
country: USA
name: Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder , Boulder, CO, USA
Affiliations: label: 1
institution: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus
country: USA
name: Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 2
institution: Computational Bioscience Program, University of Colorado Anschutz Medical Campus
country: USA
name: Computational Bioscience Program, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 3
institution: Department of Pharmacology, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Pharmacology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 4
institution: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus
country: USA
name: Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus , Aurora, CO, USA
label: 5
institution: Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder
country: USA
name: Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder , Boulder, CO, USA
Field: Neuroscience
Document type: preprint
Year: 2018