Title: The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies
Authors: orcid: https://orcid.org/0000-0002-3574-0127
last_name: Diaz
first_name: Jennifer EL
name: Jennifer EL Diaz
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 2
address: New York
institution: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai New York United States
label: 3
address: Yorktown Heights
institution: IBM Computational Biology Center, IBM Research
country: United States
name: IBM Computational Biology Center, IBM Research Yorktown Heights United States
orcid: https://orcid.org/0000-0002-4907-0427
last_name: Ahsen
first_name: Mehmet Eren
name: Mehmet Eren Ahsen
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 3
address: Yorktown Heights
institution: IBM Computational Biology Center, IBM Research
country: United States
name: IBM Computational Biology Center, IBM Research Yorktown Heights United States
label: 4
address: Champaign
institution: Department of Business Administration, University of Illinois at Urbana-Champaign
country: United States
name: Department of Business Administration, University of Illinois at Urbana-Champaign Champaign United States
last_name: Schaffter
first_name: Thomas
name: Thomas Schaffter
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 3
address: Yorktown Heights
institution: IBM Computational Biology Center, IBM Research
country: United States
name: IBM Computational Biology Center, IBM Research Yorktown Heights United States
last_name: Chen
first_name: Xintong
name: Xintong Chen
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
last_name: Realubit
first_name: Ronald B
name: Ronald B Realubit
affiliations: label: 5
address: New York
institution: Department of Systems Biology, Columbia University
country: United States
name: Department of Systems Biology, Columbia University New York United States
label: 6
address: New York
institution: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center
country: United States
name: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center New York United States
last_name: Karan
first_name: Charles
name: Charles Karan
affiliations: label: 5
address: New York
institution: Department of Systems Biology, Columbia University
country: United States
name: Department of Systems Biology, Columbia University New York United States
label: 6
address: New York
institution: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center
country: United States
name: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center New York United States
last_name: Califano
first_name: Andrea
name: Andrea Califano
affiliations: label: 5
address: New York
institution: Department of Systems Biology, Columbia University
country: United States
name: Department of Systems Biology, Columbia University New York United States
label: 7
address: New York
institution: Department of Biomedical Informatics, Columbia University
country: United States
name: Department of Biomedical Informatics, Columbia University New York United States
label: 8
address: New York
institution: Department of Biochemistry and Molecular Biophysics, Columbia University
country: United States
name: Department of Biochemistry and Molecular Biophysics, Columbia University New York United States
label: 9
address: New York
institution: Department of Medicine, Columbia University
country: United States
name: Department of Medicine, Columbia University New York United States
orcid: https://orcid.org/0000-0003-3643-4612
last_name: Losic
first_name: Bojan
name: Bojan Losic
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 10
address: New York
institution: Tisch Cancer Institute, Cancer Immunology, Icahn School of Medicine at Mount Sinai
country: United States
name: 10 Tisch Cancer Institute, Cancer Immunology, Icahn School of Medicine at Mount Sinai New York United States
label: 11
address: New York
institution: Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai
country: United States
name: 11 Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai New York United States
label: 12
address: New York
institution: Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
country: United States
name: 12 Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai New York United States
orcid: https://orcid.org/0000-0002-9618-2819
last_name: Stolovitzky
first_name: Gustavo
name: Gustavo Stolovitzky
corresponding: yes
affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 3
address: Yorktown Heights
institution: IBM Computational Biology Center, IBM Research
country: United States
name: IBM Computational Biology Center, IBM Research Yorktown Heights United States
label: 5
address: New York
institution: Department of Systems Biology, Columbia University
country: United States
name: Department of Systems Biology, Columbia University New York United States
label: 7
address: New York
institution: Department of Biomedical Informatics, Columbia University
country: United States
name: Department of Biomedical Informatics, Columbia University New York United States
Affiliations: label: 1
address: New York
institution: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai New York United States
label: 2
address: New York
institution: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
country: United States
name: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai New York United States
label: 3
address: Yorktown Heights
institution: IBM Computational Biology Center, IBM Research
country: United States
name: IBM Computational Biology Center, IBM Research Yorktown Heights United States
label: 4
address: Champaign
institution: Department of Business Administration, University of Illinois at Urbana-Champaign
country: United States
name: Department of Business Administration, University of Illinois at Urbana-Champaign Champaign United States
label: 5
address: New York
institution: Department of Systems Biology, Columbia University
country: United States
name: Department of Systems Biology, Columbia University New York United States
label: 6
address: New York
institution: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center
country: United States
name: Sulzberger Columbia Genome Center, High Throughput Screening Facility, Columbia University Medical Center New York United States
label: 7
address: New York
institution: Department of Biomedical Informatics, Columbia University
country: United States
name: Department of Biomedical Informatics, Columbia University New York United States
label: 8
address: New York
institution: Department of Biochemistry and Molecular Biophysics, Columbia University
country: United States
name: Department of Biochemistry and Molecular Biophysics, Columbia University New York United States
label: 9
address: New York
institution: Department of Medicine, Columbia University
country: United States
name: Department of Medicine, Columbia University New York United States
label: 10
address: New York
institution: Tisch Cancer Institute, Cancer Immunology, Icahn School of Medicine at Mount Sinai
country: United States
name: 10 Tisch Cancer Institute, Cancer Immunology, Icahn School of Medicine at Mount Sinai New York United States
label: 11
address: New York
institution: Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai
country: United States
name: 11 Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai New York United States
label: 12
address: New York
institution: Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
country: United States
name: 12 Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai New York United States
institution: Barcelona Supercomputing Center - BSC
country: Spain
name: Barcelona Supercomputing Center - BSC Spain
institution: The University of Hong Kong
country: Hong Kong
name: The University of Hong Kong Hong Kong
institution: Barcelona Supercomputing Center - BSC
country: Spain
name: Barcelona Supercomputing Center - BSC Spain
institution: NTNU
country: Norway
name: NTNU Norway
Field: Biochemistry, Genetics and Molecular Biology
Document type: article
Year: 2020