Title: Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses
Authors: orcid: https://orcid.org/0000-0001-9296-121X
last_name: Bucher
first_name: Michael
name: Michael Bucher
affiliations: label: 1
address: Berlin
institution: AG Optobiology, Institute of Biology, Humboldt-University
country: Germany
name: AG Optobiology, Institute of Biology, Humboldt-University Berlin Germany
label: 2
address: Hamburg
institution: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 3
address: Magdeburg
institution: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN)
country: Germany
name: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN) Magdeburg Germany
last_name: Niebling
first_name: Stephan
name: Stephan Niebling
affiliations: label: 4
address: Hamburg
institution: Molecular Biophysics and High-Throughput Crystallization, European Molecular Biology Laboratory (EMBL)
country: Germany
name: Molecular Biophysics and High-Throughput Crystallization, European Molecular Biology Laboratory (EMBL) Hamburg Germany
last_name: Han
first_name: Yuhao
name: Yuhao Han
affiliations: label: 2
address: Hamburg
institution: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 5
address: Hamburg
institution: Structural Cell Biology of Viruses, Centre for Structural Systems Biology (CSSB) and Leibniz Institute for Experimental Virology
country: Germany
name: Structural Cell Biology of Viruses, Centre for Structural Systems Biology (CSSB) and Leibniz Institute for Experimental Virology Hamburg Germany
orcid: http://orcid.org/0000-0002-5954-4294
last_name: Molodenskiy
first_name: Dmitry
name: Dmitry Molodenskiy
affiliations: label: 6
address: Hamburg
institution: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY
country: Germany
name: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY Hamburg Germany
last_name: Hassani Nia
first_name: Fatemeh
name: Fatemeh Hassani Nia
affiliations: label: 7
address: Hamburg
institution: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
orcid: http://orcid.org/0000-0002-8871-9970
last_name: Kreienkamp
first_name: Hans-Jürgen
name: Hans-Jürgen Kreienkamp
affiliations: label: 7
address: Hamburg
institution: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
last_name: Svergun
first_name: Dmitri
name: Dmitri Svergun
affiliations: label: 6
address: Hamburg
institution: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY
country: Germany
name: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY Hamburg Germany
last_name: Kim
first_name: Eunjoon
name: Eunjoon Kim
affiliations: label: 8
address: Daejeon
institution: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
country: Republic of Korea
name: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea
last_name: Kostyukova
first_name: Alla S
name: Alla S Kostyukova
affiliations: label: 2
address: Hamburg
institution: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 9
address: Pullman
institution: The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University (WSU)
country: United States
name: The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University (WSU) Pullman United States
last_name: Kreutz
first_name: Michael R
name: Michael R Kreutz
corresponding: yes
affiliations: label: 3
address: Magdeburg
institution: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN)
country: Germany
name: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN) Magdeburg Germany
label: 10
address: Hamburg
institution: Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: 10 Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 11
address: Magdeburg
institution: German Center for Neurodegenerative Diseases
country: Germany
name: 11 German Center for Neurodegenerative Diseases Magdeburg Germany
label: 12
address: Magdeburg
institution: Center for Behavioral Brain Sciences
country: Germany
name: 12 Center for Behavioral Brain Sciences Magdeburg Germany
orcid: https://orcid.org/0000-0001-7646-1346
last_name: Mikhaylova
first_name: Marina
name: Marina Mikhaylova
corresponding: yes
affiliations: label: 1
address: Berlin
institution: AG Optobiology, Institute of Biology, Humboldt-University
country: Germany
name: AG Optobiology, Institute of Biology, Humboldt-University Berlin Germany
label: 2
address: Hamburg
institution: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
Affiliations: label: 1
address: Berlin
institution: AG Optobiology, Institute of Biology, Humboldt-University
country: Germany
name: AG Optobiology, Institute of Biology, Humboldt-University Berlin Germany
label: 2
address: Hamburg
institution: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: DFG Emmy Noether Guest Group 'Neuronal Protein Transport', Institute for Molecular Neurogenetics, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 3
address: Magdeburg
institution: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN)
country: Germany
name: RG Neuroplasticity, Leibniz-Institute for Neurobiology (LIN) Magdeburg Germany
label: 4
address: Hamburg
institution: Molecular Biophysics and High-Throughput Crystallization, European Molecular Biology Laboratory (EMBL)
country: Germany
name: Molecular Biophysics and High-Throughput Crystallization, European Molecular Biology Laboratory (EMBL) Hamburg Germany
label: 5
address: Hamburg
institution: Structural Cell Biology of Viruses, Centre for Structural Systems Biology (CSSB) and Leibniz Institute for Experimental Virology
country: Germany
name: Structural Cell Biology of Viruses, Centre for Structural Systems Biology (CSSB) and Leibniz Institute for Experimental Virology Hamburg Germany
label: 6
address: Hamburg
institution: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY
country: Germany
name: European Molecular Biology Laboratory (EMBL) Hamburg Unit, DESY Hamburg Germany
label: 7
address: Hamburg
institution: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: Institute of Human Genetics, Center for Obstetrics and Pediatrics, University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 8
address: Daejeon
institution: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)
country: Republic of Korea
name: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea
label: 9
address: Pullman
institution: The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University (WSU)
country: United States
name: The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University (WSU) Pullman United States
label: 10
address: Hamburg
institution: Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE)
country: Germany
name: 10 Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany
label: 11
address: Magdeburg
institution: German Center for Neurodegenerative Diseases
country: Germany
name: 11 German Center for Neurodegenerative Diseases Magdeburg Germany
label: 12
address: Magdeburg
institution: Center for Behavioral Brain Sciences
country: Germany
name: 12 Center for Behavioral Brain Sciences Magdeburg Germany
institution: Tel Aviv University
country: Israel
name: Tel Aviv University Israel
institution: Weill Cornell Medicine
country: United States
name: Weill Cornell Medicine United States
institution: Tel Aviv University
country: Israel
name: Tel Aviv University Israel
Field: Biochemistry, Genetics and Molecular Biology
Document type: article
Year: 2021