Title: Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Authors: last_name: Macpherson
first_name: Jamie A
name: Jamie A Macpherson
affiliations: label: 1
address: London
institution: Cancer Metabolism Laboratory
country: United Kingdom
name: Cancer Metabolism Laboratory The Francis Crick Institute London United Kingdom
label: 2
address: London
institution: Randall Centre for Cell and Molecular Biophysics
country: United Kingdom
name: Randall Centre for Cell and Molecular Biophysics King’s College London London United Kingdom
orcid: http://orcid.org/0000-0002-0216-8582
last_name: Theisen
first_name: Alina
name: Alina Theisen
affiliations: label: 3
address: Manchester
institution: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry
country: United Kingdom
name: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry University of Manchester Manchester United Kingdom
last_name: Masino
first_name: Laura
name: Laura Masino
affiliations: label: 4
address: London
institution: Structural Biology Science Technology Platform
country: United Kingdom
name: Structural Biology Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Fets
first_name: Louise
name: Louise Fets
affiliations: label: 1
address: London
institution: Cancer Metabolism Laboratory
country: United Kingdom
name: Cancer Metabolism Laboratory The Francis Crick Institute London United Kingdom
last_name: Driscoll
first_name: Paul C
name: Paul C Driscoll
affiliations: label: 5
address: London
institution: Metabolomics Science Technology Platform
country: United Kingdom
name: Metabolomics Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Encheva
first_name: Vesela
name: Vesela Encheva
affiliations: label: 6
address: London
institution: Proteomics Science Technology Platform
country: United Kingdom
name: Proteomics Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Snijders
first_name: Ambrosius P
name: Ambrosius P Snijders
affiliations: label: 6
address: London
institution: Proteomics Science Technology Platform
country: United Kingdom
name: Proteomics Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Martin
first_name: Stephen R
name: Stephen R Martin
affiliations: label: 4
address: London
institution: Structural Biology Science Technology Platform
country: United Kingdom
name: Structural Biology Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Kleinjung
first_name: Jens
name: Jens Kleinjung
affiliations: label: 7
address: London
institution: Computational Biology Science Technology Platform
country: United Kingdom
name: Computational Biology Science Technology Platform The Francis Crick Institute London United Kingdom
last_name: Barran
first_name: Perdita E
name: Perdita E Barran
affiliations: label: 3
address: Manchester
institution: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry
country: United Kingdom
name: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry University of Manchester Manchester United Kingdom
orcid: http://orcid.org/0000-0002-3143-6574
last_name: Fraternali
first_name: Franca
name: Franca Fraternali
corresponding: yes
affiliations: label: 2
address: London
institution: Randall Centre for Cell and Molecular Biophysics
country: United Kingdom
name: Randall Centre for Cell and Molecular Biophysics King’s College London London United Kingdom
orcid: https://orcid.org/0000-0002-1269-843X
last_name: Anastasiou
first_name: Dimitrios
name: Dimitrios Anastasiou
corresponding: yes
affiliations: label: 1
address: London
institution: Cancer Metabolism Laboratory
country: United Kingdom
name: Cancer Metabolism Laboratory The Francis Crick Institute London United Kingdom
Affiliations: label: 1
address: London
institution: Cancer Metabolism Laboratory
country: United Kingdom
name: Cancer Metabolism Laboratory The Francis Crick Institute London United Kingdom
label: 2
address: London
institution: Randall Centre for Cell and Molecular Biophysics
country: United Kingdom
name: Randall Centre for Cell and Molecular Biophysics King’s College London London United Kingdom
label: 3
address: Manchester
institution: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry
country: United Kingdom
name: Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry University of Manchester Manchester United Kingdom
label: 4
address: London
institution: Structural Biology Science Technology Platform
country: United Kingdom
name: Structural Biology Science Technology Platform The Francis Crick Institute London United Kingdom
label: 5
address: London
institution: Metabolomics Science Technology Platform
country: United Kingdom
name: Metabolomics Science Technology Platform The Francis Crick Institute London United Kingdom
label: 6
address: London
institution: Proteomics Science Technology Platform
country: United Kingdom
name: Proteomics Science Technology Platform The Francis Crick Institute London United Kingdom
label: 7
address: London
institution: Computational Biology Science Technology Platform
country: United Kingdom
name: Computational Biology Science Technology Platform The Francis Crick Institute London United Kingdom
institution: Tel Aviv University
country: Israel
name: Tel Aviv University Israel
institution: University of California, Berkeley
country: United States
name: University of California, Berkeley United States
institution: Tel Aviv University
country: Israel
name: Tel Aviv University Israel
institution: Tel Aviv University
country: Israel
name: Tel Aviv University Israel
Field: Biochemistry, Genetics and Molecular Biology
Document type: article
Year: 2019