Title: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis
Authors: orcid: https://orcid.org/0000-0001-6308-6014
last_name: Jones
first_name: Mark G
name: Mark G Jones
corresponding: yes
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
last_name: Andriotis
first_name: Orestis G
name: Orestis G Andriotis
affiliations: label: 2
address: Getreidemarkt
institution: Institute for Lightweight Design and Structural Biomechanics
country: Austria
name: Institute for Lightweight Design and Structural Biomechanics TU Wien Getreidemarkt Austria
last_name: Roberts
first_name: James JW
name: James JW Roberts
affiliations: label: 3
address: Southampton
institution: Synairgen Research Ltd
country: United Kingdom
name: Synairgen Research Ltd Southampton United Kingdom
last_name: Lunn
first_name: Kerry
name: Kerry Lunn
affiliations: label: 3
address: Southampton
institution: Synairgen Research Ltd
country: United Kingdom
name: Synairgen Research Ltd Southampton United Kingdom
last_name: Tear
first_name: Victoria J
name: Victoria J Tear
affiliations: label: 3
address: Southampton
institution: Synairgen Research Ltd
country: United Kingdom
name: Synairgen Research Ltd Southampton United Kingdom
last_name: Cao
first_name: Lucy
name: Lucy Cao
affiliations: label: 4
address: Frenchs Forest
institution: Pharmaxis Ltd
country: Australia
name: Pharmaxis Ltd Frenchs Forest Australia
last_name: Ask
first_name: Kjetil
name: Kjetil Ask
affiliations: label: 5
address: Hamilton
institution: Department of Medicine
country: Canada
name: Department of Medicine Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton Hamilton Canada
last_name: Smart
first_name: David E
name: David E Smart
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
last_name: Bonfanti
first_name: Alessandra
name: Alessandra Bonfanti
affiliations: label: 6
address: Southampton
institution: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment
country: United Kingdom
name: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment University of Southampton Southampton United Kingdom
last_name: Johnson
first_name: Peter
name: Peter Johnson
affiliations: label: 7
address: Southampton
institution: Department of Chemistry, Faculty of Natural and Environmental Sciences
country: United Kingdom
name: Department of Chemistry, Faculty of Natural and Environmental Sciences University of Southampton Southampton United Kingdom
label: 8
address: Southampton
institution: Institute for Life Sciences
country: United Kingdom
name: Institute for Life Sciences University of Southampton Southampton United Kingdom
last_name: Alzetani
first_name: Aiman
name: Aiman Alzetani
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
last_name: Conforti
first_name: Franco
name: Franco Conforti
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
last_name: Doherty
first_name: Regan
name: Regan Doherty
affiliations: label: 10
address: Southampton
institution: Biomedical Imaging Unit, Faculty of Medicine
country: United Kingdom
name: 10 Biomedical Imaging Unit, Faculty of Medicine University of Southampton Southampton United Kingdom
last_name: Lai
first_name: Chester Y
name: Chester Y Lai
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
last_name: Johnson
first_name: Benjamin
name: Benjamin Johnson
affiliations: label: 11
address: Southampton
institution: CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine
country: United Kingdom
name: 11 CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine University of Southampton Southampton United Kingdom
last_name: Bourdakos
first_name: Konstantinos N
name: Konstantinos N Bourdakos
affiliations: label: 7
address: Southampton
institution: Department of Chemistry, Faculty of Natural and Environmental Sciences
country: United Kingdom
name: Department of Chemistry, Faculty of Natural and Environmental Sciences University of Southampton Southampton United Kingdom
label: 8
address: Southampton
institution: Institute for Life Sciences
country: United Kingdom
name: Institute for Life Sciences University of Southampton Southampton United Kingdom
last_name: Fletcher
first_name: Sophie V
name: Sophie V Fletcher
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
last_name: Marshall
first_name: Ben G
name: Ben G Marshall
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
last_name: Jogai
first_name: Sanjay
name: Sanjay Jogai
affiliations: label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
orcid: http://orcid.org/0000-0001-8302-702X
last_name: Brereton
first_name: Christopher J
name: Christopher J Brereton
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
last_name: Chee
first_name: Serena J
name: Serena J Chee
affiliations: label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
label: 11
address: Southampton
institution: CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine
country: United Kingdom
name: 11 CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine University of Southampton Southampton United Kingdom
orcid: http://orcid.org/0000-0003-3619-1657
last_name: Ottensmeier
first_name: Christian H
name: Christian H Ottensmeier
affiliations: label: 11
address: Southampton
institution: CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine
country: United Kingdom
name: 11 CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine University of Southampton Southampton United Kingdom
last_name: Sime
first_name: Patricia
name: Patricia Sime
affiliations: label: 12
address: Rochester
institution: Division of Pulmonary and Critical Care Medicine
country: United States
name: 12 Division of Pulmonary and Critical Care Medicine University of Rochester School of Medicine and Dentistry Rochester United States
last_name: Gauldie
first_name: Jack
name: Jack Gauldie
affiliations: label: 5
address: Hamilton
institution: Department of Medicine
country: Canada
name: Department of Medicine Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton Hamilton Canada
last_name: Kolb
first_name: Martin
name: Martin Kolb
affiliations: label: 5
address: Hamilton
institution: Department of Medicine
country: Canada
name: Department of Medicine Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton Hamilton Canada
last_name: Mahajan
first_name: Sumeet
name: Sumeet Mahajan
affiliations: label: 7
address: Southampton
institution: Department of Chemistry, Faculty of Natural and Environmental Sciences
country: United Kingdom
name: Department of Chemistry, Faculty of Natural and Environmental Sciences University of Southampton Southampton United Kingdom
label: 8
address: Southampton
institution: Institute for Life Sciences
country: United Kingdom
name: Institute for Life Sciences University of Southampton Southampton United Kingdom
last_name: Fabre
first_name: Aurelie
name: Aurelie Fabre
affiliations: label: 13
address: Dublin
institution: Department of Histopathology
country: Ireland
name: 13 Department of Histopathology St. Vincent's University Hospital & UCD School of Medicine, University College Dublin Dublin Ireland
last_name: Bhaskar
first_name: Atul
name: Atul Bhaskar
affiliations: label: 6
address: Southampton
institution: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment
country: United Kingdom
name: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment University of Southampton Southampton United Kingdom
last_name: Jarolimek
first_name: Wolfgang
name: Wolfgang Jarolimek
affiliations: label: 4
address: Frenchs Forest
institution: Pharmaxis Ltd
country: Australia
name: Pharmaxis Ltd Frenchs Forest Australia
last_name: Richeldi
first_name: Luca
name: Luca Richeldi
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 14
address: Rome
institution: Università Cattolica del Sacro Cuore
country: Italy
name: 14 Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy
last_name: O'Reilly
first_name: Katherine MA
name: Katherine MA O'Reilly
affiliations: label: 15
address: Dublin
institution: Mater Misericordiae University Hospital
country: Ireland
name: 15 Mater Misericordiae University Hospital Dublin Ireland
label: 16
address: Dublin
institution: School of Medicine and Medical Science
country: Ireland
name: 16 School of Medicine and Medical Science University College Dublin Dublin Ireland
last_name: Monk
first_name: Phillip D
name: Phillip D Monk
affiliations: label: 3
address: Southampton
institution: Synairgen Research Ltd
country: United Kingdom
name: Synairgen Research Ltd Southampton United Kingdom
last_name: Thurner
first_name: Philipp J
name: Philipp J Thurner
affiliations: label: 2
address: Getreidemarkt
institution: Institute for Lightweight Design and Structural Biomechanics
country: Austria
name: Institute for Lightweight Design and Structural Biomechanics TU Wien Getreidemarkt Austria
orcid: https://orcid.org/0000-0002-5117-2991
last_name: Davies
first_name: Donna E
name: Donna E Davies
corresponding: yes
affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 8
address: Southampton
institution: Institute for Life Sciences
country: United Kingdom
name: Institute for Life Sciences University of Southampton Southampton United Kingdom
Affiliations: label: 1
address: Southampton
institution: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences
country: United Kingdom
name: NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences Faculty of Medicine, University of Southampton Southampton United Kingdom
label: 2
address: Getreidemarkt
institution: Institute for Lightweight Design and Structural Biomechanics
country: Austria
name: Institute for Lightweight Design and Structural Biomechanics TU Wien Getreidemarkt Austria
label: 3
address: Southampton
institution: Synairgen Research Ltd
country: United Kingdom
name: Synairgen Research Ltd Southampton United Kingdom
label: 4
address: Frenchs Forest
institution: Pharmaxis Ltd
country: Australia
name: Pharmaxis Ltd Frenchs Forest Australia
label: 5
address: Hamilton
institution: Department of Medicine
country: Canada
name: Department of Medicine Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton Hamilton Canada
label: 6
address: Southampton
institution: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment
country: United Kingdom
name: Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment University of Southampton Southampton United Kingdom
label: 7
address: Southampton
institution: Department of Chemistry, Faculty of Natural and Environmental Sciences
country: United Kingdom
name: Department of Chemistry, Faculty of Natural and Environmental Sciences University of Southampton Southampton United Kingdom
label: 8
address: Southampton
institution: Institute for Life Sciences
country: United Kingdom
name: Institute for Life Sciences University of Southampton Southampton United Kingdom
label: 9
address: Southampton
institution: University Hospital Southampton
country: United Kingdom
name: University Hospital Southampton Southampton United Kingdom
label: 10
address: Southampton
institution: Biomedical Imaging Unit, Faculty of Medicine
country: United Kingdom
name: 10 Biomedical Imaging Unit, Faculty of Medicine University of Southampton Southampton United Kingdom
label: 11
address: Southampton
institution: CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine
country: United Kingdom
name: 11 CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine University of Southampton Southampton United Kingdom
label: 12
address: Rochester
institution: Division of Pulmonary and Critical Care Medicine
country: United States
name: 12 Division of Pulmonary and Critical Care Medicine University of Rochester School of Medicine and Dentistry Rochester United States
label: 13
address: Dublin
institution: Department of Histopathology
country: Ireland
name: 13 Department of Histopathology St. Vincent's University Hospital & UCD School of Medicine, University College Dublin Dublin Ireland
label: 14
address: Rome
institution: Università Cattolica del Sacro Cuore
country: Italy
name: 14 Università Cattolica del Sacro Cuore Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy
label: 15
address: Dublin
institution: Mater Misericordiae University Hospital
country: Ireland
name: 15 Mater Misericordiae University Hospital Dublin Ireland
label: 16
address: Dublin
institution: School of Medicine and Medical Science
country: Ireland
name: 16 School of Medicine and Medical Science University College Dublin Dublin Ireland
institution: Columbia University
country: United States
name: Columbia University United States
institution: Columbia University
country: United States
name: Columbia University United States
Field: Biochemistry, Genetics and Molecular Biology
Document type: article
Year: 2018