Title: Genomic risk prediction of coronary artery disease in nearly 500,000 adults: implications for early screening and primary prevention
Authors: last_name: Inouye
first_name: Michael
name: Michael Inouye
corresponding: yes
affiliations: label: 1
institution: Systems Genomics Lab, Baker Heart and Diabetes Institute
country: Australia
name: Systems Genomics Lab, Baker Heart and Diabetes Institute , 75 Commercial Rd, Melbourne 3004, Victoria, Australia
label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 3
institution: Department of Clinical Pathology and School of BioSciences, University of Melbourne
country: Australia
name: Department of Clinical Pathology and School of BioSciences, University of Melbourne , Parkville 3010, Victoria, Australia
notes: These authors contributed equally
last_name: Abraham
first_name: Gad
name: Gad Abraham
corresponding: yes
affiliations: label: 1
institution: Systems Genomics Lab, Baker Heart and Diabetes Institute
country: Australia
name: Systems Genomics Lab, Baker Heart and Diabetes Institute , 75 Commercial Rd, Melbourne 3004, Victoria, Australia
label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 3
institution: Department of Clinical Pathology and School of BioSciences, University of Melbourne
country: Australia
name: Department of Clinical Pathology and School of BioSciences, University of Melbourne , Parkville 3010, Victoria, Australia
notes: These authors contributed equally
last_name: Nelson
first_name: Christopher P.
name: Christopher P. Nelson
affiliations: label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
last_name: Wood
first_name: Angela M.
name: Angela M. Wood
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
last_name: Sweeting
first_name: Michael J.
name: Michael J. Sweeting
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
last_name: Dudbridge
first_name: Frank
name: Frank Dudbridge
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 5
institution: Department of Health Sciences, University of Leicester
country: United Kingdom
name: Department of Health Sciences, University of Leicester , Leicester, United Kingdom
last_name: Lai
first_name: Florence Y.
name: Florence Y. Lai
affiliations: label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
last_name: Kaptoge
first_name: Stephen
name: Stephen Kaptoge
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 6
institution: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge
country: United Kingdom
name: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge , Cambridge, United Kingdom
last_name: Brozynska
first_name: Marta
name: Marta Brozynska
affiliations: label: 1
institution: Systems Genomics Lab, Baker Heart and Diabetes Institute
country: Australia
name: Systems Genomics Lab, Baker Heart and Diabetes Institute , 75 Commercial Rd, Melbourne 3004, Victoria, Australia
label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 3
institution: Department of Clinical Pathology and School of BioSciences, University of Melbourne
country: Australia
name: Department of Clinical Pathology and School of BioSciences, University of Melbourne , Parkville 3010, Victoria, Australia
last_name: Wang
first_name: Tingting
name: Tingting Wang
affiliations: label: 1
institution: Systems Genomics Lab, Baker Heart and Diabetes Institute
country: Australia
name: Systems Genomics Lab, Baker Heart and Diabetes Institute , 75 Commercial Rd, Melbourne 3004, Victoria, Australia
last_name: Ye
first_name: Shu
name: Shu Ye
affiliations: label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
last_name: Webb
first_name: Thomas R
name: Thomas R Webb
affiliations: label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
last_name: Rutter
first_name: Martin K.
name: Martin K. Rutter
affiliations: label: 7
institution: Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre
country: United Kingdom
name: Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, United Kingdom
label: 8
institution: Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre
country: United Kingdom
name: Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester, United Kingdom
last_name: Tzoulaki
first_name: Ioanna
name: Ioanna Tzoulaki
affiliations: label: 9
institution: Department of Epidemiology and Biostatistics, Imperial College London
country: United Kingdom
name: Department of Epidemiology and Biostatistics, Imperial College London , London W2 1PG, United Kingdom
label: 10
institution: Department of Hygiene and Epidemiology, University of Ioannina
country: Greece
name: 10 Department of Hygiene and Epidemiology, University of Ioannina , 45110, Ioannina, Greece
last_name: Patel
first_name: Riyaz S.
name: Riyaz S. Patel
affiliations: label: 11
institution: Institute of Cardiovascular Sciences, University College London
country: United Kingdom
name: 11 Institute of Cardiovascular Sciences, University College London , London, United Kingdom
label: 12
institution: Barts Heart Centre, St Bartholomew’s Hospital
country: United Kingdom
name: 12 Barts Heart Centre, St Bartholomew’s Hospital , London, United Kingdom
last_name: Loos
first_name: Ruth J.F.
name: Ruth J.F. Loos
affiliations: label: 13
institution: Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute
country: USA
name: 13 Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute , Icahn School of Medicine at Mount Sinai, New York, New York, USA
last_name: Keavney
first_name: Bernard
name: Bernard Keavney
affiliations: label: 14
institution: Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
country: United Kingdom
name: 14 Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester , Manchester, United Kingdom
label: 15
institution: Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre
country: United Kingdom
name: 15 Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester, United Kingdom
last_name: Hemingway
first_name: Harry
name: Harry Hemingway
affiliations: label: 16
institution: The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London
country: United Kingdom
name: 16 The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London , London, United Kingdom
last_name: Thompson
first_name: John
name: John Thompson
affiliations: label: 5
institution: Department of Health Sciences, University of Leicester
country: United Kingdom
name: Department of Health Sciences, University of Leicester , Leicester, United Kingdom
last_name: Watkins
first_name: Hugh
name: Hugh Watkins
affiliations: label: 17
institution: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
country: United Kingdom
name: 17 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford , Oxford, OX3 9DU, United Kingdom
label: 18
institution: The Wellcome Trust Centre for Human Genetics, University of Oxford
country: United Kingdom
name: 18 The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, OX3 7BN, United Kingdom
last_name: Deloukas
first_name: Panos
name: Panos Deloukas
affiliations: label: 19
institution: William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
country: United Kingdom
name: 19 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, EC1M 6BQ, United Kingdom
last_name: Angelantonio
first_name: Emanuele Di
name: Emanuele Di Angelantonio
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 6
institution: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge
country: United Kingdom
name: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge , Cambridge, United Kingdom
last_name: Butterworth
first_name: Adam S.
name: Adam S. Butterworth
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 6
institution: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge
country: United Kingdom
name: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge , Cambridge, United Kingdom
last_name: Danesh
first_name: John
name: John Danesh
affiliations: label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 6
institution: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge
country: United Kingdom
name: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge , Cambridge, United Kingdom
label: 20
institution: Wellcome Trust Sanger Institute
country: United Kingdom
name: 20 Wellcome Trust Sanger Institute , Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
last_name: Samani
first_name: Nilesh J.
name: Nilesh J. Samani
corresponding: yes
affiliations: label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
notes: These authors contributed equally
Affiliations: label: 1
institution: Systems Genomics Lab, Baker Heart and Diabetes Institute
country: Australia
name: Systems Genomics Lab, Baker Heart and Diabetes Institute , 75 Commercial Rd, Melbourne 3004, Victoria, Australia
label: 2
institution: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
country: United Kingdom
name: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge CB1 8RN, United Kingdom
label: 3
institution: Department of Clinical Pathology and School of BioSciences, University of Melbourne
country: Australia
name: Department of Clinical Pathology and School of BioSciences, University of Melbourne , Parkville 3010, Victoria, Australia
label: 4
institution: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester
country: United Kingdom
name: Department of Cardiovascular Sciences and NIHR Leicester Biomedical Centre, University of Leicester , United Kingdom
label: 5
institution: Department of Health Sciences, University of Leicester
country: United Kingdom
name: Department of Health Sciences, University of Leicester , Leicester, United Kingdom
label: 6
institution: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge
country: United Kingdom
name: National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge , Cambridge, United Kingdom
label: 7
institution: Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre
country: United Kingdom
name: Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, United Kingdom
label: 8
institution: Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre
country: United Kingdom
name: Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester, United Kingdom
label: 9
institution: Department of Epidemiology and Biostatistics, Imperial College London
country: United Kingdom
name: Department of Epidemiology and Biostatistics, Imperial College London , London W2 1PG, United Kingdom
label: 10
institution: Department of Hygiene and Epidemiology, University of Ioannina
country: Greece
name: 10 Department of Hygiene and Epidemiology, University of Ioannina , 45110, Ioannina, Greece
label: 11
institution: Institute of Cardiovascular Sciences, University College London
country: United Kingdom
name: 11 Institute of Cardiovascular Sciences, University College London , London, United Kingdom
label: 12
institution: Barts Heart Centre, St Bartholomew’s Hospital
country: United Kingdom
name: 12 Barts Heart Centre, St Bartholomew’s Hospital , London, United Kingdom
label: 13
institution: Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute
country: USA
name: 13 Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute , Icahn School of Medicine at Mount Sinai, New York, New York, USA
label: 14
institution: Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester
country: United Kingdom
name: 14 Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester , Manchester, United Kingdom
label: 15
institution: Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre
country: United Kingdom
name: 15 Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester, United Kingdom
label: 16
institution: The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London
country: United Kingdom
name: 16 The Farr Institute of Health Informatics Research and the National Institute for Health Research, Biomedical Research Centre, University College London , London, United Kingdom
label: 17
institution: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford
country: United Kingdom
name: 17 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford , Oxford, OX3 9DU, United Kingdom
label: 18
institution: The Wellcome Trust Centre for Human Genetics, University of Oxford
country: United Kingdom
name: 18 The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, OX3 7BN, United Kingdom
label: 19
institution: William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
country: United Kingdom
name: 19 William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, EC1M 6BQ, United Kingdom
label: 20
institution: Wellcome Trust Sanger Institute
country: United Kingdom
name: 20 Wellcome Trust Sanger Institute , Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2018