Title: Genome-wide mapping identifies beta-1,4-N-acetyl-galactosaminyl-transferase as a novel determinant of sclerostin levels and bone mineral density
Authors: last_name: Zheng
first_name: Jie
name: Jie Zheng
corresponding: yes
affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
last_name: Maerz
first_name: Winfried
name: Winfried Maerz
affiliations: label: 2
institution: Clinical Institute of Medical and Chemical Laboratory Diagnostics
country: Austria
name: Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University of Graz, Austria
label: 3
institution: SYNLAB Academy, SYNLAB Holding Deutschland GmbH
country: Germany
name: SYNLAB Academy, SYNLAB Holding Deutschland GmbH , Mannheim, Germany
label: 4
institution: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim
country: Germany
name: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim , University of Heidelberg, Mannheim, Germany
last_name: Gergei
first_name: Ingrid
name: Ingrid Gergei
affiliations: label: 4
institution: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim
country: Germany
name: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim , University of Heidelberg, Mannheim, Germany
last_name: Kleber
first_name: Marcus
name: Marcus Kleber
affiliations: label: 4
institution: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim
country: Germany
name: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim , University of Heidelberg, Mannheim, Germany
last_name: Drechsler
first_name: Christiane
name: Christiane Drechsler
affiliations: label: 5
institution: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center
country: Germany
name: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center , University of Würzburg, Germany
last_name: Wanner
first_name: Christoph
name: Christoph Wanner
affiliations: label: 5
institution: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center
country: Germany
name: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center , University of Würzburg, Germany
last_name: Brandenburg
first_name: Vincent
name: Vincent Brandenburg
affiliations: label: 5
institution: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center
country: Germany
name: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center , University of Würzburg, Germany
last_name: Reppe
first_name: Sjur
name: Sjur Reppe
affiliations: label: 6
institution: Institute of Basic Medical Sciences
country: Norway
name: Institute of Basic Medical Sciences , University of Oslo. Oslo, Norway
label: 7
institution: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital
country: Norway
name: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital , Oslo, Norway
last_name: Gautvik
first_name: Kaare M
name: Kaare M Gautvik
affiliations: label: 7
institution: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital
country: Norway
name: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital , Oslo, Norway
label: 8
institution: Department of Medical Biochemistry, Oslo University Hospital
country: Norway
name: Department of Medical Biochemistry, Oslo University Hospital , Oslo, Norway
last_name: Medina-Gomez
first_name: Carolina
name: Carolina Medina-Gomez
affiliations: label: 9
institution: Department of Internal Medicine, Erasmus MC University Medical Center
country: The Netherlands
name: Department of Internal Medicine, Erasmus MC University Medical Center , Rotterdam, The Netherlands
last_name: Shevroja
first_name: Enisa
name: Enisa Shevroja
affiliations: label: 9
institution: Department of Internal Medicine, Erasmus MC University Medical Center
country: The Netherlands
name: Department of Internal Medicine, Erasmus MC University Medical Center , Rotterdam, The Netherlands
last_name: Gilly
first_name: Arthur
name: Arthur Gilly
affiliations: label: 10
institution: Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus
country: United Kingdom
name: 10 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton, CB10 1SA, United Kingdom
label: 11
institution: Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health
country: Germany
name: 11 Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health , Neuherberg, Germany
last_name: Park
first_name: Young-Chan
name: Young-Chan Park
affiliations: label: 10
institution: Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus
country: United Kingdom
name: 10 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton, CB10 1SA, United Kingdom
label: 12
institution: University of Cambridge
country: UK
name: 12 University of Cambridge , Cambridge, UK
last_name: Dedoussis
first_name: George
name: George Dedoussis
affiliations: label: 13
institution: Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University
country: Greece
name: 13 Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University , El. Venizelou 70, 17671, Athens, Greece
last_name: Zeggini
first_name: Eleftheria
name: Eleftheria Zeggini
affiliations: label: 10
institution: Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus
country: United Kingdom
name: 10 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton, CB10 1SA, United Kingdom
label: 11
institution: Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health
country: Germany
name: 11 Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health , Neuherberg, Germany
last_name: Lorentzon
first_name: Mattias
name: Mattias Lorentzon
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
label: 15
institution: Geriatric Medicine, Institute of Medicine
country: Sweden
name: 15 Geriatric Medicine, Institute of Medicine , University of Gothenburg, Sweden
label: 16
institution: Geriatric Medicine Clinic, Sahlgrenska University Hospital
country: Sweden
name: 16 Geriatric Medicine Clinic, Sahlgrenska University Hospital , Mölndal, Sweden
last_name: Henning
first_name: Petra
name: Petra Henning
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Lerner
first_name: Ulf H.
name: Ulf H. Lerner
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Nilsson
first_name: Karin
name: Karin Nilsson
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Movérare-Skrtic
first_name: Sofia
name: Sofia Movérare-Skrtic
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Baird
first_name: Denis
name: Denis Baird
affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
last_name: Falk
first_name: Louise
name: Louise Falk
affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
last_name: Groom
first_name: Alix
name: Alix Groom
affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
label: 17
institution: Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School
country: UK
name: 17 Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School , University of Bristol, UK
last_name: Capellini
first_name: Terence D.
name: Terence D. Capellini
affiliations: label: 18
institution: Human Evolutionary Biology
country: USA
name: 18 Human Evolutionary Biology , Harvard University, USA
label: 19
institution: Broad Institute of MIT and Harvard
country: USA
name: 19 Broad Institute of MIT and Harvard , USA
last_name: Grundberg
first_name: Elin
name: Elin Grundberg
affiliations: label: 20
institution: Department of Human Genetics, McGill University
country: Canada
name: 20 Department of Human Genetics, McGill University , Quebec, Canada
label: 21
institution: Center for Pediatric Genomic Medicine
country: USA
name: 21 Center for Pediatric Genomic Medicine , Children’s Mercy Kansas City, USA
last_name: Nethander
first_name: Maria
name: Maria Nethander
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Ohlsson
first_name: Claes
name: Claes Ohlsson
affiliations: label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
last_name: Smith
first_name: George Davey
name: George Davey Smith
affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
notes: Equal contributions
last_name: Tobias
first_name: Jonathan H.
name: Jonathan H. Tobias
corresponding: yes
affiliations: label: 22
institution: Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building
country: United Kingdom
name: 22 Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building , Bristol, BS10 5NB, United Kingdom
notes: Equal contributions
Affiliations: label: 1
institution: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House
country: United Kingdom
name: MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House , Oakfield Grove, Bristol, BS8 2BN, United Kingdom
label: 2
institution: Clinical Institute of Medical and Chemical Laboratory Diagnostics
country: Austria
name: Clinical Institute of Medical and Chemical Laboratory Diagnostics , Medical University of Graz, Austria
label: 3
institution: SYNLAB Academy, SYNLAB Holding Deutschland GmbH
country: Germany
name: SYNLAB Academy, SYNLAB Holding Deutschland GmbH , Mannheim, Germany
label: 4
institution: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim
country: Germany
name: Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim , University of Heidelberg, Mannheim, Germany
label: 5
institution: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center
country: Germany
name: Department of Internal Medicine 1, Division of Nephrology and the Comprehensive Heart Failure Center , University of Würzburg, Germany
label: 6
institution: Institute of Basic Medical Sciences
country: Norway
name: Institute of Basic Medical Sciences , University of Oslo. Oslo, Norway
label: 7
institution: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital
country: Norway
name: Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital , Oslo, Norway
label: 8
institution: Department of Medical Biochemistry, Oslo University Hospital
country: Norway
name: Department of Medical Biochemistry, Oslo University Hospital , Oslo, Norway
label: 9
institution: Department of Internal Medicine, Erasmus MC University Medical Center
country: The Netherlands
name: Department of Internal Medicine, Erasmus MC University Medical Center , Rotterdam, The Netherlands
label: 10
institution: Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus
country: United Kingdom
name: 10 Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton, CB10 1SA, United Kingdom
label: 11
institution: Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health
country: Germany
name: 11 Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health , Neuherberg, Germany
label: 12
institution: University of Cambridge
country: UK
name: 12 University of Cambridge , Cambridge, UK
label: 13
institution: Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University
country: Greece
name: 13 Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University , El. Venizelou 70, 17671, Athens, Greece
label: 14
institution: Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition
country: Sweden
name: 14 Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition , Institute of Medicine, University of Gothenburg, Sweden
label: 15
institution: Geriatric Medicine, Institute of Medicine
country: Sweden
name: 15 Geriatric Medicine, Institute of Medicine , University of Gothenburg, Sweden
label: 16
institution: Geriatric Medicine Clinic, Sahlgrenska University Hospital
country: Sweden
name: 16 Geriatric Medicine Clinic, Sahlgrenska University Hospital , Mölndal, Sweden
label: 17
institution: Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School
country: UK
name: 17 Bristol Bioresource Laboratories, Population Health Sciences, Bristol Medical School , University of Bristol, UK
label: 18
institution: Human Evolutionary Biology
country: USA
name: 18 Human Evolutionary Biology , Harvard University, USA
label: 19
institution: Broad Institute of MIT and Harvard
country: USA
name: 19 Broad Institute of MIT and Harvard , USA
label: 20
institution: Department of Human Genetics, McGill University
country: Canada
name: 20 Department of Human Genetics, McGill University , Quebec, Canada
label: 21
institution: Center for Pediatric Genomic Medicine
country: USA
name: 21 Center for Pediatric Genomic Medicine , Children’s Mercy Kansas City, USA
label: 22
institution: Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building
country: United Kingdom
name: 22 Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building , Bristol, BS10 5NB, United Kingdom
Field: Medicine
Document type: preprint
Year: 2018