Title: C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition
Authors: orcid: http://orcid.org/0000-0002-1693-871X
last_name: Butler
first_name: Victoria J.
name: Victoria J. Butler
affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
last_name: Cortopassi
first_name: Wilian A.
name: Wilian A. Cortopassi
affiliations: label: 2
institution: Department of Pharmaceutical Chemistry, University of California
country: U.S.A.
name: Department of Pharmaceutical Chemistry, University of California , San Francisco, California, 94143, U.S.A.
last_name: Argouarch
first_name: Andrea R.
name: Andrea R. Argouarch
affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
last_name: Pierce
first_name: M. Olivia
name: M. Olivia Pierce
affiliations: label: 2
institution: Department of Pharmaceutical Chemistry, University of California
country: U.S.A.
name: Department of Pharmaceutical Chemistry, University of California , San Francisco, California, 94143, U.S.A.
notes: Current address: Schrödinger, Inc., 120 West 45th Street, New York, New York, 10036, U.S.A
last_name: Vohra
first_name: Mihir
name: Mihir Vohra
affiliations: label: 3
institution: Department of Physiology, University of California
country: U.S.A.
name: Department of Physiology, University of California , San Francisco, California, 94143, U.S.A.
orcid: http://orcid.org/0000-0003-4759-2341
last_name: Oses-Prieto
first_name: Juan A.
name: Juan A. Oses-Prieto
affiliations: label: 4
institution: Department of Chemistry, University of California
country: U.S.A.
name: Department of Chemistry, University of California , San Francisco, California, 94143, U.S.A.
last_name: Gao
first_name: Fuying
name: Fuying Gao
affiliations: label: 5
institution: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles
country: U.S.A.
name: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California, 90095, U.S.A.
last_name: Caballero
first_name: Benjamin
name: Benjamin Caballero
affiliations: label: 6
institution: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
country: U.S.A.
name: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , New York, New York, U.S.A.
last_name: Chand
first_name: Shreya
name: Shreya Chand
affiliations: label: 4
institution: Department of Chemistry, University of California
country: U.S.A.
name: Department of Chemistry, University of California , San Francisco, California, 94143, U.S.A.
last_name: Seeley
first_name: William W.
name: William W. Seeley
affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
label: 7
institution: Department of Pathology, University of California
country: U.S.A.
name: Department of Pathology, University of California , San Francisco, California, 94143, U.S.A.
last_name: Miller
first_name: Bruce L.
name: Bruce L. Miller
affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
last_name: Coppola
first_name: Giovanni
name: Giovanni Coppola
affiliations: label: 5
institution: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles
country: U.S.A.
name: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California, 90095, U.S.A.
last_name: Burlingame
first_name: Alma L.
name: Alma L. Burlingame
affiliations: label: 4
institution: Department of Chemistry, University of California
country: U.S.A.
name: Department of Chemistry, University of California , San Francisco, California, 94143, U.S.A.
last_name: Ashrafi
first_name: Kaveh
name: Kaveh Ashrafi
affiliations: label: 3
institution: Department of Physiology, University of California
country: U.S.A.
name: Department of Physiology, University of California , San Francisco, California, 94143, U.S.A.
last_name: Cuervo
first_name: Ana Maria
name: Ana Maria Cuervo
affiliations: label: 6
institution: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
country: U.S.A.
name: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , New York, New York, U.S.A.
last_name: Jacobson
first_name: Matthew P.
name: Matthew P. Jacobson
affiliations: label: 2
institution: Department of Pharmaceutical Chemistry, University of California
country: U.S.A.
name: Department of Pharmaceutical Chemistry, University of California , San Francisco, California, 94143, U.S.A.
orcid: http://orcid.org/0000-0002-7686-7968
last_name: Kao
first_name: Aimee W.
name: Aimee W. Kao
corresponding: yes
affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
Affiliations: label: 1
institution: Memory and Aging Center, Department of Neurology, University of California
country: U.S.A.
name: Memory and Aging Center, Department of Neurology, University of California , San Francisco, California, 94143, U.S.A.
label: 2
institution: Department of Pharmaceutical Chemistry, University of California
country: U.S.A.
name: Department of Pharmaceutical Chemistry, University of California , San Francisco, California, 94143, U.S.A.
label: 3
institution: Department of Physiology, University of California
country: U.S.A.
name: Department of Physiology, University of California , San Francisco, California, 94143, U.S.A.
label: 4
institution: Department of Chemistry, University of California
country: U.S.A.
name: Department of Chemistry, University of California , San Francisco, California, 94143, U.S.A.
label: 5
institution: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles
country: U.S.A.
name: Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and Biobehavioral Sciences and Neurology, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California, 90095, U.S.A.
label: 6
institution: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
country: U.S.A.
name: Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , New York, New York, U.S.A.
label: 7
institution: Department of Pathology, University of California
country: U.S.A.
name: Department of Pathology, University of California , San Francisco, California, 94143, U.S.A.
Field: Medicine
Document type: preprint
Year: 2018