Title: Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays
Authors: last_name: Urban
first_name: Daniel J.
name: Daniel J. Urban
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Martinez
first_name: Natalia J.
name: Natalia J. Martinez
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Davis
first_name: Mindy I.
name: Mindy I. Davis
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Brimacombe
first_name: Kyle R.
name: Kyle R. Brimacombe
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Cheff
first_name: Dorian M.
name: Dorian M. Cheff
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Lee
first_name: Tobie D.
name: Tobie D. Lee
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Henderson
first_name: Mark J.
name: Mark J. Henderson
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Titus
first_name: Steven A.
name: Steven A. Titus
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Pragani
first_name: Rajan
name: Rajan Pragani
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Rohde
first_name: Jason M.
name: Jason M. Rohde
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Wang
first_name: Yuhong
name: Yuhong Wang
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Karavadhi
first_name: Surendra
name: Surendra Karavadhi
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Shah
first_name: Pranav
name: Pranav Shah
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Lee
first_name: Olivia W.
name: Olivia W. Lee
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Wang
first_name: Amy
name: Amy Wang
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: McIver
first_name: Andrew
name: Andrew McIver
affiliations: label: 2.
institution: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine
name: 2. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine , Chapel Hill, NC
last_name: Zheng
first_name: Hongchao
name: Hongchao Zheng
affiliations: label: 2.
institution: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine
name: 2. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine , Chapel Hill, NC
last_name: Wang
first_name: Xiaodong
name: Xiaodong Wang
affiliations: label: 2.
institution: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine
name: 2. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine , Chapel Hill, NC
last_name: Xu
first_name: Xin
name: Xin Xu
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Jadhav
first_name: Ajit
name: Ajit Jadhav
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Simeonov
first_name: Anton
name: Anton Simeonov
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Shen
first_name: Min
name: Min Shen
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Boxer
first_name: Matthew B.
name: Matthew B. Boxer
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
last_name: Hall
first_name: Matthew D.
name: Matthew D. Hall
corresponding: yes
affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
Affiliations: label: 1.
institution: NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health
country: United States
name: 1. NCATS Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, Maryland 20850, United States
label: 2.
institution: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine
name: 2. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina School of Medicine , Chapel Hill, NC
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2017