Title: Regional missense constraint improves variant deleteriousness prediction
Authors: last_name: Samocha
first_name: Kaitlin E.
name: Kaitlin E. Samocha
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 3
institution: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
country: USA
name: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 4
institution: Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School
country: USA
name: Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School , Boston, Massachusetts, USA .
last_name: Kosmicki
first_name: Jack A.
name: Jack A. Kosmicki
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 3
institution: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
country: USA
name: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 5
institution: Program in Bioinformatics and Integrative Genomics, Harvard University
country: USA
name: Program in Bioinformatics and Integrative Genomics, Harvard University , Cambridge, Massachusetts, USA .
last_name: Karczewski
first_name: Konrad J.
name: Konrad J. Karczewski
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
last_name: O’Donnell-Luria
first_name: Anne H.
name: Anne H. O’Donnell-Luria
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 6
institution: Division of Genetics and Genomics, Boston Children’s Hospital
country: USA
name: Division of Genetics and Genomics, Boston Children’s Hospital , Boston, Massachusetts, USA .
last_name: Pierce-Hoffman
first_name: Emma
name: Emma Pierce-Hoffman
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
last_name: MacArthur
first_name: Daniel G.
name: Daniel G. MacArthur
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
last_name: Neale
first_name: Benjamin M.
name: Benjamin M. Neale
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 3
institution: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
country: USA
name: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
last_name: Daly
first_name: Mark J.
name: Mark J. Daly
corresponding: yes
affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 3
institution: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
country: USA
name: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
Affiliations: label: 1
institution: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital
country: USA
name: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts, USA .
label: 2
institution: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
country: USA
name: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 3
institution: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
country: USA
name: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA .
label: 4
institution: Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School
country: USA
name: Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School , Boston, Massachusetts, USA .
label: 5
institution: Program in Bioinformatics and Integrative Genomics, Harvard University
country: USA
name: Program in Bioinformatics and Integrative Genomics, Harvard University , Cambridge, Massachusetts, USA .
label: 6
institution: Division of Genetics and Genomics, Boston Children’s Hospital
country: USA
name: Division of Genetics and Genomics, Boston Children’s Hospital , Boston, Massachusetts, USA .
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2017