Title: Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
Authors: last_name: Rohde
first_name: Jason M.
name: Jason M. Rohde
corresponding: yes
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Brimacombe
first_name: Kyle R.
name: Kyle R. Brimacombe
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Liu
first_name: Li
name: Li Liu
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
label: h
institution: Department of Radiation Oncology, New York University Medical Center
name: Department of Radiation Oncology, New York University Medical Center , 522 First Avenue, Smilow 907, New York, NY 10016
last_name: Pacold
first_name: Michael E.
name: Michael E. Pacold
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Yasgar
first_name: Adam
name: Adam Yasgar
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Cheff
first_name: Dorian M.
name: Dorian M. Cheff
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Lee
first_name: Tobie D.
name: Tobie D. Lee
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Rai
first_name: Ganesha
name: Ganesha Rai
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Baljinnyam
first_name: Bolormaa
name: Bolormaa Baljinnyam
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Li
first_name: Zhuyin
name: Zhuyin Li
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
label: i
institution: Bristol-Myers Squibb, Lead Discovery and Optimization
name: Bristol-Myers Squibb, Lead Discovery and Optimization , 3551 Lawrenceville Road, Princeton, NJ 08540
last_name: Simeonov
first_name: Anton
name: Anton Simeonov
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Hall
first_name: Matthew D.
name: Matthew D. Hall
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Shen
first_name: Min
name: Min Shen
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
last_name: Sabatini
first_name: David M.
name: David M. Sabatini
affiliations: label: b
institution: Whitehead Institute for Biomedical Research
country: USA
name: Whitehead Institute for Biomedical Research , 9 Cambridge Center, Cambridge, MA, 02142, USA
label: e
institution: Broad Institute of Harvard and Massachusetts Institute of Technology
country: USA
name: Broad Institute of Harvard and Massachusetts Institute of Technology , 7 Cambridge Center, Cambridge, MA 02142, USA
last_name: Boxer
first_name: Matthew B.
name: Matthew B. Boxer
affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
label: j
institution: Nexus Discovery Advisors
name: Nexus Discovery Advisors , 7820B Wormans Mill Road, Suite 208, Frederick, MD 21701
Affiliations: label: a
institution: National Center for Advancing Translational Sciences, National Institutes of Health
country: USA
name: National Center for Advancing Translational Sciences, National Institutes of Health , 9800 Medical Center Drive, Rockville, MD, 20850, USA
label: b
institution: Whitehead Institute for Biomedical Research
country: USA
name: Whitehead Institute for Biomedical Research , 9 Cambridge Center, Cambridge, MA, 02142, USA
label: c
institution: Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology
country: USA
name: Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology , Cambridge, MA 02139, USA
label: d
institution: Koch Institute for Integrative Cancer Research
country: USA
name: Koch Institute for Integrative Cancer Research , 77 Massachusetts Avenue, Cambridge, MA 02139, USA
label: e
institution: Broad Institute of Harvard and Massachusetts Institute of Technology
country: USA
name: Broad Institute of Harvard and Massachusetts Institute of Technology , 7 Cambridge Center, Cambridge, MA 02142, USA
label: f
institution: Dana-Farber Cancer Institute
country: USA
name: Dana-Farber Cancer Institute , Longwood Center, 350 Longwood Avenue, Boston, MA 02215, USA
label: g
institution: Department of Radiation Oncology, Dana-Farber Cancer Institute
country: USA
name: Department of Radiation Oncology, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, MA 02215, USA
label: h
institution: Department of Radiation Oncology, New York University Medical Center
name: Department of Radiation Oncology, New York University Medical Center , 522 First Avenue, Smilow 907, New York, NY 10016
label: i
institution: Bristol-Myers Squibb, Lead Discovery and Optimization
name: Bristol-Myers Squibb, Lead Discovery and Optimization , 3551 Lawrenceville Road, Princeton, NJ 08540
label: j
institution: Nexus Discovery Advisors
name: Nexus Discovery Advisors , 7820B Wormans Mill Road, Suite 208, Frederick, MD 21701
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2018