Title: The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8
Authors: orcid: http://orcid.org/0000-0002-5860-2616
last_name: Chen
first_name: Shi
name: Shi Chen
affiliations: label: 1
institution: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
country: USA
name: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
notes: These authors made equal contribution
orcid: http://orcid.org/0000-0002-8961-7183
last_name: Wiewiora
first_name: Rafal P.
name: Rafal P. Wiewiora
affiliations: label: 1
institution: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
country: USA
name: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 3
institution: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
notes: These authors made equal contribution
orcid: http://orcid.org/0000-0003-2886-7012
last_name: Meng
first_name: Fanwang
name: Fanwang Meng
affiliations: label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
notes: Current address: Department of Chemistry and Chemical Biology, McMaster University, Ontario, L8S 4L8, Canada
last_name: Babault
first_name: Nicolas
name: Nicolas Babault
affiliations: label: 5
institution: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
country: USA
name: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029, USA
last_name: Ma
first_name: Anqi
name: Anqi Ma
affiliations: label: 5
institution: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
country: USA
name: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029, USA
last_name: Yu
first_name: Wenyu
name: Wenyu Yu
affiliations: label: 6
institution: Structural Genomics Consortium, University of Toronto
country: Canada
name: Structural Genomics Consortium, University of Toronto , Toronto, Ontario, M5G 1L7, Canada
last_name: Qian
first_name: Kun
name: Kun Qian
affiliations: label: 7
institution: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
country: USA
name: Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, Georgia, 30602, USA
last_name: Hu
first_name: Hao
name: Hao Hu
affiliations: label: 7
institution: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
country: USA
name: Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, Georgia, 30602, USA
last_name: Zou
first_name: Hua
name: Hua Zou
affiliations: label: 8
institution: Takeda California, 10410 Science Center Drive
country: USA
name: Takeda California, 10410 Science Center Drive , San Diego, CA 92121, USA
last_name: Wang
first_name: Junyi
name: Junyi Wang
affiliations: label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
last_name: Fan
first_name: Shijie
name: Shijie Fan
affiliations: label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
label: 9
institution: University of Chinese Academy of Sciences
country: China
name: University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 100049, China
last_name: Blum
first_name: Gil
name: Gil Blum
affiliations: label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
orcid: http://orcid.org/0000-0002-9644-7098
last_name: Pittella-Silva
first_name: Fabio
name: Fabio Pittella-Silva
affiliations: label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
orcid: http://orcid.org/0000-0001-6095-8788
last_name: Beauchamp
first_name: Kyle A.
name: Kyle A. Beauchamp
affiliations: label: 3
institution: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
last_name: Tempel
first_name: Wolfram
name: Wolfram Tempel
affiliations: label: 6
institution: Structural Genomics Consortium, University of Toronto
country: Canada
name: Structural Genomics Consortium, University of Toronto , Toronto, Ontario, M5G 1L7, Canada
last_name: Jiang
first_name: Hualiang
name: Hualiang Jiang
affiliations: label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
label: 9
institution: University of Chinese Academy of Sciences
country: China
name: University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 100049, China
last_name: Chen
first_name: Kaixian
name: Kaixian Chen
affiliations: label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
label: 9
institution: University of Chinese Academy of Sciences
country: China
name: University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 100049, China
last_name: Skene
first_name: Robert
name: Robert Skene
affiliations: label: 8
institution: Takeda California, 10410 Science Center Drive
country: USA
name: Takeda California, 10410 Science Center Drive , San Diego, CA 92121, USA
orcid: http://orcid.org/0000-0001-7116-3067
last_name: Zheng
first_name: Y. George
name: Y. George Zheng
affiliations: label: 7
institution: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
country: USA
name: Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, Georgia, 30602, USA
last_name: Brown
first_name: Peter J.
name: Peter J. Brown
affiliations: label: 6
institution: Structural Genomics Consortium, University of Toronto
country: Canada
name: Structural Genomics Consortium, University of Toronto , Toronto, Ontario, M5G 1L7, Canada
orcid: http://orcid.org/0000-0002-2387-3862
last_name: Jin
first_name: Jian
name: Jian Jin
affiliations: label: 5
institution: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
country: USA
name: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029, USA
orcid: http://orcid.org/0000-0003-3864-8382
last_name: Luo
first_name: Cheng
name: Cheng Luo
corresponding: yes
affiliations: label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
label: 9
institution: University of Chinese Academy of Sciences
country: China
name: University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 100049, China
orcid: http://orcid.org/0000-0003-0542-119X
last_name: Chodera
first_name: John D.
name: John D. Chodera
corresponding: yes
affiliations: label: 3
institution: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
orcid: http://orcid.org/0000-0001-7409-7034
last_name: Luo
first_name: Minkui
name: Minkui Luo
corresponding: yes
affiliations: label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 10
institution: Program of Pharmacology, Weill Cornell Medical College of Cornell University
country: USA
name: 10 Program of Pharmacology, Weill Cornell Medical College of Cornell University , New York, New York 10021, USA
Affiliations: label: 1
institution: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center
country: USA
name: Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 2
institution: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Chemical Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 3
institution: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center
country: USA
name: Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York 10065, USA
label: 4
institution: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
country: China
name: Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, China
label: 5
institution: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
country: USA
name: Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, NY 10029, USA
label: 6
institution: Structural Genomics Consortium, University of Toronto
country: Canada
name: Structural Genomics Consortium, University of Toronto , Toronto, Ontario, M5G 1L7, Canada
label: 7
institution: Department of Pharmaceutical and Biomedical Sciences, University of Georgia
country: USA
name: Department of Pharmaceutical and Biomedical Sciences, University of Georgia , Athens, Georgia, 30602, USA
label: 8
institution: Takeda California, 10410 Science Center Drive
country: USA
name: Takeda California, 10410 Science Center Drive , San Diego, CA 92121, USA
label: 9
institution: University of Chinese Academy of Sciences
country: China
name: University of Chinese Academy of Sciences , 19 Yuquan Road, Beijing 100049, China
label: 10
institution: Program of Pharmacology, Weill Cornell Medical College of Cornell University
country: USA
name: 10 Program of Pharmacology, Weill Cornell Medical College of Cornell University , New York, New York 10021, USA
Field: Biochemistry, Genetics and Molecular Biology
Document type: preprint
Year: 2018