The 2000s saw the rise of first Liverpool, and then Arsenal to real competitiveness, Chelsea finally breaking the duopoly by winning in 2004-05. The dominance of the so-called "Top Four" clubs. Arsenal, Chelsea, Liverpool and Manchester United saw them finish at the top of the table for the bulk of the decade, thereby guaranteeing qualification for the UEFA Champions League. Only three other clubs managed to qualify for the competition during this period: Newcastle United (2001–02 and 2002–03), Everton (2004–05) and Tottenham Hotspur (2009–10) – each occupying the final Champions League spot, with the exception of Newcastle in the 2002–03 season, who finished third.

Following the 2003–04 season, Arsenal acquired the nickname "The Invincibles" as it became the first, and to date, only club to complete a Premier League campaign without losing a single game.

In May 2008, Kevin Keegan stated that "Top Four" dominance threatened the division: "This league is in danger of becoming one of the most boring but great leagues in the world." Premier League chief executive Richard Scudamore said in defence: "There are a lot of different tussles that go on in the Premier League depending on whether you're at the top, in the middle or at the bottom that make it interesting."

Between 2005 and 2012 there was a Premier League representative in seven of the eight Champions League finals, with only "Top Four" clubs reaching that stage. Liverpool (2005), Manchester United (2008) and Chelsea (2012) won the competition during this period, with Arsenal (2006), Liverpool (2007), Chelsea (2008) and Manchester United (2009 and 2011) all losing Champions League finals. Leeds United were the only non-"Top Four" side to reach the semi-finals of the Champions League, in the 2000–01 season. There were three Premier League teams in the Champions League semi-finals in 2006–07, 2007–08, and 2008–09, a feat only ever achieved five times (along with Serie A in 2002–03 and La Liga in 1999–2000).

Additionally, between the 1999–2000 and 2009–10 seasons, four Premier League sides reached UEFA Cup or Europa League finals, with only Liverpool managing to win the competition in 2001. Arsenal (2000), Middlesbrough (2006) and Fulham (2010) all lost their finals.

Although the group's dominance was reduced to a degree after this period with the emergence of Manchester City and Tottenham, in terms of all-time Premier League points won they remain clear by some margin. As of the end of the 2021–22 season – the 27th season of the Premier League – Liverpool, in fourth place in the all-time points table, were over 300 points ahead of the next team, Tottenham Hotspur. They are also the only teams to maintain a winning average of over 50% throughout their entire Premier League tenures.
Who are the top 4 in EPL?
Arsenal, Liverpool, Manchester United and Chelsea are know as the "Top Four" in the English Premier league.