Tamazulapam del Espíritu Santo is a town and municipality in Oaxaca in south-western Mexico. The municipality is at an altitude of 2,040 meters. It is part of the Sierra Mixe district within the Sierra Norte de Oaxaca Region.

The municipality has a total population of 6,908, and the town has a population of 2,372.

Municipal President Artemio Ortiz Ricardez died on May 13, 2020 during the COVID-19 pandemic in Mexico. The town had been placed under quarantine after its first reported case on May 10.
Why was Tamazulapam del Espíritu Santo placed under quarantine?
Tamazulapam del Espíritu Santo was placed under quarantine due to the COVID-19 pandemic.