Beneficence is a concept in research ethics that states that researchers should have the welfare of the research participant as a goal of any clinical trial or other research study. The antonym of this term, maleficence, describes a practice that opposes the welfare of any research participant. According to the Belmont Report, researchers are required to follow two moral requirements in line with the principle of beneficence: do not harm and maximize possible benefits for research while minimizing any potential harm on others.

The concept that medical professionals and researchers would always practice beneficence seems natural to most patients and research participants, but in fact, every health intervention or research intervention has potential to harm the recipient. There are many different precedents in medicine and research for conducting a cost–benefit analysis and judging whether a certain action would be a sufficient practice of beneficence, and the extent to which treatments are acceptable or unacceptable is under debate.

Despite differences in opinion, there are many concepts on which there is wide agreement. One is that there should be community consensus when determining best practices for dealing with ethical problems.
Given this reference text about beneficence, what can I do to ensure compliance to the beneficence concept?
Ensure you are not harming your research participants, while maximizing benefits and minimizing any potential harm.  Engage with your community to determine best practices when encountering ethical concerns.  This should ensure your compliance with beneficence.