What is the meaning of Life, The Universe, and Everything?
This topic has been discussed in debt by Theologians, philosophers, and scientists throughout the course of human history.  While most observations about the universe leave the question unanswered the broad strokes are as follows.

Theologians state in many religions that there is an organizing force known as God providing direction to the universe.  Humans that best align with this organizing force or God are guaranteed good fortune in this life or after.  There are variations in humans level of involvement in this process with Christianity requiring a savior (Jesus) for people to enter the afterlife vs achieving a higher state of consciousness in this life or through reincarnation.

Philosophers differ on the meaning of life with predominate views following down the lines of seeking your own fulfillment or the fulfillment of others.  Seeking your own fulfillment has been a major component of capitalism, self-preservation, and risk taking that lead to new discoveries in Science and Technology.  Seeking the fulfillment of others has lead to great advancements in philanthropy, equality, and the general well being of society.  This "social compact" insures stability and provides an expectation that harmful activities like Murder, Robbery, etc are discouraged and punished.

Scientists view this question through the lens of the observable universe.  As such efforts have been made to create a "unifying theory of everything" to show some understandable order to the universe.  Others have focused their study on the improbability of how humans could have been created in a universe with seemingly random and infinite chance.  Some scientists have conceded that the question is something Science is ill-fitted to answer.

Most importantly Douglas Adams, a prominent British author specializing in absurdity, answered the question in the book "The Hitchhikers Guide to the Galaxy" with the answer "42."