The Battle of Issus (also Issos) occurred in southern Anatolia, on 5 November 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III. It was the second great battle of Alexander's conquest of Asia, and the first encounter between Darius III and Alexander the Great. The battle resulted in the Macedonian troops defeating the Persian forces.

After the Hellenic League soundly defeated the Persian satraps of Asia Minor (led by Greek mercenary Memnon of Rhodes) at the Battle of the Granicus, Darius took personal command of his army. He gathered reinforcements and proceeded to lead his men in a surprise march behind the Hellenic advance, in order to cut off their line of supply. Alexander was forced to countermarch, and the stage was set for the battle near the mouth of the Pinarus River and the town of Issus.
Given this paragraph about battles under Alexander the Great what battle occurred prior to the battle of Issus
the Battle of the Granicus