East Side of Manhattan refers to the side of Manhattan which abuts the East River and faces Brooklyn and Queens. Fifth Avenue, Central Park from 59th to 110th Streets, and Broadway below 8th Street separate it from the West Side.

The major neighborhoods on the East Side include (from north to south) East Harlem, Yorkville, the Upper East Side, Turtle Bay, Murray Hill, Kips Bay, Gramercy, East Village, and the Lower East Side. The main north–south expressways servicing the East Side are the Franklin D. Roosevelt East River Drive and Harlem River Drive, which for the majority of their length are separated from the east shore of the island by the Manhattan Waterfront Greenway. The East Side is served by the IRT East Side Line subway and by many bus lines.

The West Side of Manhattan refers to the side of Manhattan Island which abuts the Hudson River and faces the U.S. state of New Jersey. Fifth Avenue, Central Park, and lower Broadway separate it from the East Side. The major neighborhoods on the West Side are (from north to south) Inwood, Hudson Heights, Washington Heights, West Harlem, Morningside Heights, Manhattan Valley, Upper West Side, Hell's Kitchen, Chelsea, West Village, SoHo, and Tribeca. The 8th Avenue and West Side subway lines connect all parts of the West Side.

The main north-south roads servicing the West Side are the Henry Hudson Parkway in the north, and the West Side Highway in the south. The Hudson River Greenway separates those highways from the western shore of the island.
List the major neighborhoods on the East Side and West Side of Manhattan.
East Side: East Harlem, Yorkville, the Upper East Side, Turtle Bay, Murray Hill, Kips Bay, Gramercy, East Village, and the Lower East Side

West Side: Inwood, Hudson Heights, Washington Heights, West Harlem, Morningside Heights, Manhattan Valley, Upper West Side, Hell's Kitchen, Chelsea, West Village, SoHo, and Tribeca