Moret was born in 1953 in Vevey Switzerland, and did his undergraduate studies at the École Polytechnique Fédérale de Lausanne (EPFL), graduating in 1975. He went on to graduate studies at the University of Tennessee, earning a Ph.D. in 1980. He then joined the faculty of the University of New Mexico, where he remained until 2006, when he moved to EPFL. He retired from EPFL in December 2016.

In 1996, Moret founded the ACM Journal of Experimental Algorithmics, and he remained editor in chief of the journal until 2003. In 2001, Moret founded the Workshop in Algorithms for Bioinformatics (WABI) and remains on the Steering Committee for the conference.

In 2018, Moret was elected as a Fellow of the International Society for Computational Biology, for his outstanding contributions to the fields of computational biology and bioinformatics.
Extract universities Moret studied at and his year of graduation for each, and put them in a bulleted list.
* École Polytechnique Fédérale de Lausanne (EPFL) (graduated 1975)
* University of Tennessee (graduated 1980)