The 2010 Tennessee Titans season was the team's 41st season in the National Football League, their 51st overall and their 14th season in Tennessee. The Titans hoped to improve on their 8–8 record from the 2009 season, but they failed to do so and ended up finishing 6-10. They started the season 5-2, but lost the next 8 of 9. This was the Titans’ final season under head coach Jeff Fisher, who resigned on January 27, 2011 after 17 seasons with the team.

Offseason
Personnel changes
On January 25, Kennedy Pola, who previously served as the Jacksonville Jaguars' running backs coach for the past five seasons, was hired to the same position with the Titans, replacing Earnest Byner, who was fired the same day. (Ironically, Byner was later named the new Jaguars' running backs coach ten days later.) On May 14, Ruston Webster, who served as the Seattle Seahawks' vice president of player personnel for the past four seasons, was hired to the same position with the Titans.

On July 27, Kennedy Pola left the Titans and accepted the offensive coordinator position at USC. On July 28, the following changes were made to the Titans' coaching staff: Craig Johnson was moved from quarterbacks coach to the running backs coach vacated by Kennedy Pola, and will also serve as assistant head coach. Dowell Loggains, who previously served as quality control of offense, was named the new quarterbacks coach, while offensive assistant Richie Hessman will serve as quality control of offense.
How many seasons was Jeff Fisher the head coach of the Titans while they were not in Tennessee?
3 seasons