page_title: Segmental duplication on the human Y chromosome
section_title: Human Y Chromosome
hierarchical_section_title: Segmental duplication on the human Y chromosome / Human Y Chromosome
caption_attribution_description: English: Segmental Duplications on Human Y Chromosome
context_page_description: Segmental duplication are blocks of DNA ranging from 1 to 400 kb in length which recur at multiple sites within the genome, sharing greater than 90% similarity. Multiple studies have found a correlation between the location of segmental duplications and regions of chromosomal instability. This correlation suggests that they may be mediators of some genomic disorders. Segmental duplications are shown to be flanked on both sides by large homologous repeats, which exposes the region to recurrent rearrangement by nonallelic homologous recombination, leading to either deletion, duplication, or inversion of the original sequence.
context_section_description: The human Y chromosome contains the greatest proportion of duplicated sequence within the human genome at 50.4%. The majority of the chromosome (41Mb out of 63Mb) is made up of three blocks of highly reiterated satellites and other repeats. The other 22Mb euchromatin region also has a unique genetic structure with large gene-rich palindromes.
caption: Segmental duplications in the euchromatin/heterochromatin transition regions on the human Y chromosome
exif: {"Image Orientation": "Horizontal (normal)"}