page_title: FAM149B1
section_title: DNA Microarray Data
hierarchical_section_title: FAM149B1 / Expression / DNA Microarray Data
caption_attribution_description: English: A microarray experiment displaying lowered gene expression levels of FAM149B1 in an ovarian cancer cell line after the use of NSC319726 anticancer drug.
context_page_description: The Family with sequence similarity 149 member B1 is an uncharacterized protein encoded by the human FAM149B1 gene, with one alias KIAA0974. The protein resides in the nucleus of the cell. The predicted secondary structure of the gene contains multiple alpha-helices, with a few beta-sheet structures. The gene is conserved in mammals, birds, reptiles, fish, and some invertebrates. The protein encoded by this gene contains a DUF3719 protein domain, which is conserved across its orthologues. The protein is expressed at slightly below average levels in most human tissue types, with high expression in brain, kidney, and testes tissues, while showing relatively low expression levels in pancreas tissues.
context_section_description: DNA microarray analysis experiments show expression patterns of FAM149B1 compared to multiple other genes in a sample. FAM149B1 is shown to be at a lower expression level than most other genes in a multiple myeloma cell line and was shown to increase to close to average gene expression levels after the beta-catenin was depleted from the sample.
  FAM149B1 expression was also shown to decrease to lower than average gene expression levels in an ovarian cancer cell line after the use of an anticancer drug named NSC319726.
caption: A microarray experiment displaying lowered gene expression levels of FAM149B1 in an ovarian cancer cell line after the use of NSC319726 anticancer drug.[13]
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