page_title: Glycogen storage disease type VI
section_title: Signs/symptoms
hierarchical_section_title: Glycogen storage disease type VI / Signs/symptoms
caption_attribution_description: English: Glycogen Phosphorylase Dimer with Glycogen Binding Site, AMP Allosteric Site, Ser14, and Catalytic Site Labeled
context_page_description: Glycogen storage disease type VI is a type of glycogen storage disease caused by a deficiency in liver glycogen phosphorylase or other components of the associated phosphorylase cascade system. It is also known as "Hers' disease", after Henri G. Hers, who characterized it in 1959. The scope of GSD VI now also includes glycogen storage disease type VIII, IX and X.
  The incidence of GSD VI is approximately 1 case per 65,000–85,000 births, representing approximately 30% all cases of glycogen storage disease.
context_section_description: Patients generally have a benign course, and typically present with hepatomegaly and growth retardation early in childhood.  Mild hypoglycemia, hyperlipidemia, and hyperketosis may occur.  Lactic acid and uric acid levels may be normal.  However, lactic acidosis may occur during fasting.
caption: GlycogenPhosphorylase
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