page_title: N-acetylglucosamine-6-phosphate deacetylase
section_title: Biological Function
hierarchical_section_title: N-acetylglucosamine-6-phosphate deacetylase / Biological Function
caption_attribution_description: English: Conversion of GlcNAc into GlcN-6-P to be either converted into a new peptidoglycan for the cell wall or Fructose-6-phosphate for the gluconeogenesis pathway.
context_page_description: In enzymology, N-acetylglucosamine-6-phosphate deacetylase, also known as GlcNAc-6-phosphate deacetylase or NagA, is an enzyme that catalyzes the deacetylation of N-acetylglucosamine-6-phosphate to glucosamine-6-phosphate:
  H₂O + N-acetyl-D-glucosamine 6-phosphate acetate + D-glucosamine 6-phosphate
  GlcNAc-6-phosphate deacetylase is encoded by the gene NagA.
  This enzyme belongs to the amidohydrolase superfamily. Amidohydrolases are a type of hydrolase that acts upon amide bonds. All members of the amidohydrolase family employ a TIM barrel structure, and a vast majority of members are metalloenzymes. The family of enzymes is important in amino acid and nucleotide metabolism as well as biodegradation of agricultural and industrial compounds. NagA participates in amino-sugar metabolism, specifically in the biosynthesis of amino-sugar-nucleotides.
context_section_description: NagA is located in the cytoplasm of the cell. N-acetylglucosamine (GlcNAc) enters the cell as part of the breakdown of the cell wall. GlcNAc, a monosaccharide and derivative of glucose, is part of a biopolymer in the bacterial cell wall. This biopolymer forms a layered structure called peptidoglycan (PG). GlcNAc is then converted into GlcNAc-6-P by the enzyme NagE. This substrate is then deacetylated into acetate and GlcN-6-P by NagA. NagA is important for the production of GlcN-6-P, which is then used in two main pathways: PG recycling pathway and the glycolysis pathway.
caption: NagA Pathway in Bacteria
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