page_title: Glycoside hydrolase family 48
hierarchical_section_title: Glycoside hydrolase family 48
caption_attribution_description: English: Cartoon representation of the molecular structure of protein registered with 1g9j code. Deutsch: Grafik des Molekularstruktur von jenem Protein, das mit 1g9j code registriert ist. Plattdüütsch: Grafik, de de Molekularstruktur von dat Protein wiest, dat mit’n Kood 1g9j registreert is.
context_page_description: In molecular biology, glycoside hydrolase family 48 is a family of glycoside hydrolases.
  Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
  Glycoside hydrolase family 48 CAZY GH_48 comprises enzymes with several known activities; endoglucanase; cellobiohydrolase.
  An example of an enzyme containing a domain belonging to this family is one of the cellulases from the genome of the thermophilic anaerobic bacterium Caldocellum saccharolyticum. The celA gene product is a polypeptide of 1751 amino acids; this has a multidomain structure comprising two catalytic domains and two cellulose-binding domains, linked by Pro-Thr-rich regions.
context_section_description: In molecular biology, glycoside hydrolase family 48 is a family of glycoside hydrolases.
  Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.
  Glycoside hydrolase family 48 CAZY GH_48 comprises enzymes with several known activities; endoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91).
  An example of an enzyme containing a domain belonging to this family is one of the cellulases (celA) from the genome of the thermophilic anaerobic bacterium Caldocellum saccharolyticum. The celA gene product is a polypeptide of 1751 amino acids; this has a multidomain structure comprising two catalytic domains and two cellulose-binding domains, linked by Pro-Thr-rich regions. The N-terminal domain encodes an endoglucanase activity on carboxymethylcellulose, consistent with its similarity to several endo-1, 4-beta-D-glucanase sequences, and is a member of the glycoside hydrolase family 9. The C-terminal domain belongs to this family shows similarity to a cellulase from Clostridium thermocellum (CelS), which acts synergistically with a second component to hydrolyse crystalline cellulose.
caption: x-tal structure of the mutant e44q of the cellulase cel48f in complex with a thiooligosaccharide
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