page_title: Aflatoxin B1
hierarchical_section_title: Aflatoxin B1
caption_attribution_description: English: AflatoxinB1 日本語: AflatoxinB1（アフラトキシンB1）
context_page_description: Aflatoxin B₁ is an aflatoxin produced by Aspergillus flavus and A. parasiticus. It is a very potent carcinogen with a TD₅₀ 3.2 μg/kg/day in rats. This carcinogenic potency varies across species with some, such as rats and monkeys, seemingly much more susceptible than others. Aflatoxin B₁ is a common contaminant in a variety of foods including peanuts, cottonseed meal, corn, and other grains; as well as animal feeds. Aflatoxin B₁ is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma in humans. In animals, aflatoxin B₁ has also been shown to be mutagenic, teratogenic, and to cause immunosuppression. Several sampling and analytical methods including thin-layer chromatography, high-performance liquid chromatography, mass spectrometry, and enzyme-linked immunosorbent assay, among others, have been used to test for aflatoxin B₁ contamination in foods. According to the Food and Agriculture Organization, the worldwide maximum tolerated levels of aflatoxin B₁ was reported to be in the range of 1–20 µg/kg in food, and 5–50 µg/kg in dietary cattle feed in 2003.
context_section_description: Aflatoxin B₁ is an aflatoxin produced by Aspergillus flavus and A. parasiticus. It is a very potent carcinogen with a TD₅₀ 3.2 μg/kg/day in rats. This carcinogenic potency varies across species with some, such as rats and monkeys, seemingly much more susceptible than others. Aflatoxin B₁ is a common contaminant in a variety of foods including peanuts, cottonseed meal, corn, and other grains; as well as animal feeds. Aflatoxin B₁ is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans. In animals, aflatoxin B₁ has also been shown to be mutagenic, teratogenic, and to cause immunosuppression. Several sampling and analytical methods including thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), mass spectrometry, and enzyme-linked immunosorbent assay (ELISA), among others, have been used to test for aflatoxin B₁ contamination in foods. According to the Food and Agriculture Organization (FAO), the worldwide maximum tolerated levels of aflatoxin B₁ was reported to be in the range of 1–20 µg/kg in food, and 5–50 µg/kg in dietary cattle feed in 2003.
caption: 3D structure of aflatoxin B1
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