page_title: IDDM11
section_title: Gene location of IDDM
hierarchical_section_title: IDDM11 / Gene location of IDDM
caption_attribution_description: English: Ideogram of human chromosome 14. G-band, 550 bphs (bands per haploid set). Black and gray: Giemsa positive. Red: Centromere. Light blue: Variable region. Dark blue: Stalk. Mbp: Mega base pairs. 日本語: ヒト14番染色体のバンド図。G分染法、550 bphs (bands per haploid set、ハプロイドセット当たりバンド数）。黒および灰色はギムザ染色で染まる部分を、赤色はセントロメアを、淡い青色は変異領域を、濃い青色は付随体柄を、それぞれ表す。Mbpはメガベースペア、百万塩基対を表す。
context_page_description: Insulin-dependent diabetes mellitus is a genetic heterogenouse autoimmune disorder, which is triggered by genetic predisposition and environmental factors. The prevalence of insulin-dependent diabetes mellitus among children and young adult from Europe is approximately 0.4%. Insulin-dependent diabetes mellitus is characterized by acute onset and insulin deficiency. Patients with insulin-dependent diabetes mellitus are found with gradual loss of the pancreatic islet beta cells and therefore not able to produce insulin. As a result, they usually need exogenous insulin to maintain their life.
context_section_description: Genome-wide linkage analysis could be used for identification in susceptibility genes of insulin-dependent (type I) diabetes mellitus (IDDM). This analysis verifies that eighteen different genome regions are predisposed to insulin-dependent (type I) diabetes mellitus(IDDM). There are 18 different symbols of genome region, which is labeled from IDDM1 to IDDM18. The MHC HLA gene (IDDM1) and the insulin gene INS (IDDM2) are the major genetic candidates in the development of insulin-dependent (type I) diabetes mellitus(IDDM), which are located on the chromosome 6p21.3 and chromosome 11p15 respectively. IDDM3, IDDM4, IDDM5 IDDM7 reside in chromosome 15q26, chromosome 11q13, chromosome 6q25 and 2q31 respectively.IDDM11 (insulin-dependent diabetes mellitus 11) is one of the susceptibility genes for IDDM which locates on chromosome 14q24.3-q31. This loci is identified by linkage to D14S67 marker via a sibling-pair linkage analysis Based on the previous study, the biological behavior of IDDM11is different to HLA region genes so that IDDM11 is less predisposing to HLA. Moreover, IDDM11 has more involvement on the families that are less predisposing to HLA, while IDDM11 has less involvement on the families that are more predisposing to HLA.
  The rest of susceptibility genes locus in insulin-dependent (type I) diabetes mellitus (IDDM)are shown in table 1.
  Table 1 The locus for susceptibility genes for IDDM.
caption: Human chromosome 14 - 550 bphs
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