오기노 슈지 (, 1968년 4월 24일 ~)는 분자병리역학자이자 병리학자이며 역학자이다. 그는 현재 하버드 의학대학원 브리검 여성병원의 병리학 교수이며 하버드 T.H. 찬 보건대학원의 부교수로 재직중이다. 그는 분자병리역학이라는 새로운 분야를 개척한 것으로 이름을 알렸다. 분자병리역학이란, 분자병리학과 역학을 접목한 학제간 과학분야이다. 오기노는 1993년 일본 도쿄 의과대학을 졸업하고 2001년 도쿄 의과대학원을 졸업하였다. 그는 1994년에서 1995년까지 일본 오키나와 미해군병원(U.S. Naval Hospital Okinawa)에서 인턴으로 근무한 뒤 미국으로 건너가 1995년부터 1997년까지 필라델피아의 드렉셀 대학(Drexel University) 소속 앨러게니 종합병원(Allegheny General Hospital) (1995년~1997년)과 케이스 웨스턴 리저브 대학(Case Western Reserve University) 소속 케이스 대학병원(University Hospitals Case Medical Center) (1997~1999)에서 해부병리/진단검사의학 전공의 과정을 수료하였다. 그는 펜실베니아 대학병원(University of Pennsylvania Medical Center)에서 1999년부터 2000년까지 분자병리과 전임의로 일하였고 2001년부터 다나 파버 암연구소(Dana-Farber Cancer Institute), 브리검 여성병원(Brigham and Women’s Hospital) 및 하버드 의과대학(Harvard Medical School)에서 병리학 임상강사 일을 시작하여 2004년에는 조교수로, 2008년에는 부교수로 승진하였고 2015년에 정교수가 되었다. 그는 2010년에 하버드 T.H. Chan 보건대학원(Harvard T.H. Chan School of Public Health)에서 역학(疫學) 석사학위를 받고 2012년 동 대학원의 부교수가 되었다. 오기노는 2010년에, 역학을 배경으로 한 분자병리 연구를 독립된 분야로 간주할 것을 제안하면서, “분자병리역학 (Molecular Pathological Epidemiology, MPE)” 이라는 용어를 사용하였다.1 그의 이러한 제안을 시작으로 분자병리역학이라는 개념과 패러다임이 광범위하게 퍼져 사용되었고, 23456789101112 분자병리역학은 미국 암연구회 (American Association for Cancer Research, AACR),13 역학 연구회 (Society for Epidemiologic Research, SER),14 미국 종양예방학회(American Society of Preventive Oncology, ASPO) 15 와 같은 국제 학회에서 논의되었다. 분자병리역학적 접근은 분자병리학을 역학에 적용하여 분자적, 개체적 및 인구학적 레벨에서 병의 원인을 밝히는 것을 목표로 한다. 병리조직과 역학조사로 얻어진 데이터를 이용하여 그는 병의 위험요인 (예>환경, 식이, 생활습관 및 유전적 요인)과 분자병리학적 특질 (예>대장직장암의 PIK3CA 돌연변이)의 관계를 규명하는 많은 수의 연구논문을 출판하였다.1617181920212223242526272829303132 분자병리역학적 접근을 이용한 오기노의 발견들에는, 대장직장암에서 아스피린 복용과 PIK3CA돌연변이의 상호작용,33 내시경 검진과 CpG 아일랜드 메틸레이터 표현형 (CpG island methylator phenotype, CIMP) 및 마이크로세털라이트 불안정성 (microsattelite instability, MSI) 를 가진 대장직장암 발병과의 연관성 등이 있다.34 그는 2013년에 국제 분자병리역학회 (International Molecular Pathological Epidemiology Meeting)를 처음으로 열고 학회장을 역임하였으며 두번째 학회는 2014년 12월 4일과 5일에 보스턴에서 열렸다.35 오기노는 대장직장암 연구에 분자병리역학적 개념을 도입하여 패러다임 전환을 제안하였다. 그는 대장을 근위대장과 원위대장으로 나누는 두개의 대장 개념에서 대장직장 연속성 모델로의 개념의 전환을 제안하였는데 이 제안은 1,400개 이상의 대장작장암 증례의 데이터베이스에서 MSI, CIMP, BRAF 돌연변이의 빈도와 대장직장암의 발생위치의 선형적 상호작용을 관찰함으로써 얻어진 결과였다.41 이러한 대장직장 연속성 모델을 지지하는 다른 연구자들이 내놓은 결과들도 있다.4243 그는 이 외에도 전장유전체연관성분석-분자병리역학적 접근 (The GWAS-MPE approach),44 특이 암 원리(the unique tumor principal),45 특이 질병 원리(the unique disease principle),46 병인의 장 효과 모델(the etiologic field effect model),47과 같은 새로운 인식체계와 연구체계를 소개하였는데 이들은 모두 분자병리역학과 관련이 있는 것들이다. 2004 Executive Officer’s Award, Association for Molecular Pathology (AMP) 2011 Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology 2012 Meritorious Service Award, Association for Molecular Pathology (AMP) 2014 The Most Influential Scientific Minds 2014, by Thomson Reuters 48 2014- Elected Member, American Society for Clinical Investigation (ASCI) 2014- Member, FASEB Excellence in Science Award Committee 49 # Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer the evolving field of molecular pathological epidemiology editorial. J Natl Cancer Inst 2010;102:365-367. # # Curtin K, Slattery ML, Samowitz WS (2011). "CpG island methylation in colorectal cancer past, present and future". Pathology Research International 2011 902674. doi:10.4061/2011/902674. PMC 3090226. PMID 21559209. # # Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Arndt H, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA (2012). "Cancer classification using the Immunoscore a worldwide task force". Journal of Translational Medicine 10 205. doi:10.1186/1479-5876-10-205. PMC 3554496. PMID 23034130. # # Ku CS, Cooper DN, Wu M, Roukos DH, Pawitan Y, Soong R, Iacopetta B (August 2012). "Gene discovery in familial cancer syndromes by exome sequencing prospects for the elucidation of familial colorectal cancer type X". Modern Pathology an Official Journal of the United States and Canadian Academy of Pathology, Inc 25 (8) 1055–68. doi:10.1038/modpathol.2012.62. PMID 22522846. # # Koshiol J, Lin SW (July 2012). "Can tissue-based immune markers be used for studying the natural history of cancer?". Annals of Epidemiology 22 (7) 520–30. doi:10.1016/j.annepidem.2012.03.001. PMC 3596808. PMID 22481034. # # Fini L, Grizzi F, Laghi L (2012). Ettarh R, ed. Adaptive and Innate Immunity, Non Clonal Players in Colorectal Cancer Progression. InTech. pp. 323–40. . # Jump up ^ Dogan S, Shen R, Ang DC, Johnson ML, D Angelo SP, Paik PK, Brzostowski EB, Riely GJ, Kris MG, Zakowski MF, Ladanyi M (November 2012). "Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas higher susceptibility of women to smoking-related KRAS-mutant cancers". Clinical Cancer Research 18 (22) 6169–77. doi:10.1158/1078-0432.CCR-11-3265. PMC 3500422. PMID 23014527. # # Spitz MR, Caporaso NE, Sellers TA (December 2012). "Integrative cancer epidemiology--the next generation". Cancer Discovery 2 (12) 1087–90. doi:10.1158/2159-8290.CD-12-0424. PMC 3531829. PMID 23230187. # # Shanmuganathan R, Basheer NB, Amirthalingam L, Muthukumar H, Kaliaperumal R, Shanmugam K (January 2013). "Conventional and nanotechniques for DNA methylation profiling". The Journal of Molecular Diagnostics JMD 15 (1) 17–26. doi:10.1016/j.jmoldx.2012.06.007. PMID 23127612. # # Hughes LA, Melotte V, de Schrijver J, de Maat M, Smit VT, Bovée JV, French PJ, van den Brandt PA, Schouten LJ, de Meyer T, van Criekinge W, Ahuja N, Herman JG, Weijenberg MP, van Engeland M (October 2013). "The CpG island methylator phenotype what s in a name?". Cancer Research 73 (19) 5858–68. doi:10.1158/0008-5472.CAN-12-4306. PMID 23801749. # # Hagland HR, Søreide K (March 2014). "Cellular metabolism in colorectal carcinogenesis Influence of lifestyle, gut microbiome and metabolic pathways". Cancer Letters. doi:10.1016/j.canlet.2014.02.026. PMID 24614287. # # Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R, Mariani-Costantini R (May 2014). "Epidemiological transition of colorectal cancer in developing countries environmental factors, molecular pathways, and opportunities for prevention". World Journal of Gastroenterology WJG 20 (20) 6055–72. doi:10.3748/wjg.v20.i20.6055. PMC 4033445. PMID 24876728. # # Ogino S. Molecular pathological epidemiology (MPE) Overview of its paradigm and wide applicability even without tumor tissue abstract. In Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. . Cancer Prev Res (Phila). 2013;6(11 suppl):CN06-1. # # Kuller LH, Bracken MB, Ogino S, Prentice RL, Tracy RP. The role of epidemiology in the era of molecular epidemiology and genomics Summary of the 2013 AJE-sponsored Society of Epidemiologic Research Symposium. Am J Epidemiol. 2013;178(9):1350-4. # Epplein M, Bostick RM, Mu L, Ogino S, Braithwaite D, Kanetsky PA. Challenges and Opportunities in International Molecular Cancer Prevention Research An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report. Cancer Epidemiol Biomarkers Prev. 2014:in press (published online). # # Chan AT, Ogino S, Fuchs CS. Aspirin use and risk of colorectal cancer according to cyclooxygenase-2 expression. N Engl J Med 2007;356:2131-42. # Jump up ^ Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 2009;302:649-658. # # Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS, Ogino S. Association of CTNNB1 (β-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. JAMA 2011;305:1685-1694. PMCID:PMC3087286109 # # Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, Davis A, Mongare MM, Gould J, Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A, Lo RS, Flaherty KT, Ogino S, Wargo JA, Golub TR. Tumor microenvironment contributes to innate RAF-inhibitor resistance through HGF secretion. Nature 2012;487:500-504. PMCID:PMC3711467 # # Nishihara R, Lochhead P, Kuchiba A, Jung S, Yamauchi M, Liao X, Imamura Y, Qian ZR, Morikawa T, Wang M, Spiegelman D, Cho E, Giovannucci E, Fuchs CS, Chan AT, Ogino S. Aspirin use and colorectal cancer incidence risk according to BRAF mutation status. JAMA 2013;309:2563-2571. # # Ogino S, Liao X, Imamura Y, Yamauchi M, McCleary NJ, Ng K, Niedzwiecki D, Saltz LB, Mayer RJ, Whittom R, Hantel A, Benson III AB, Mowat RB, Spiegelman D, Goldberg RM, Bertagnolli MM, Meyerhardt JA, Fuchs CS, for the Alliance for Clinical Trials in Oncology. Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial. J Natl Cancer Inst 2013;105:1789-1798. # # Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 2013;493:106-110. PMCID:PMC3536889 # # Fink SP, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs CS, Ogino S, Markowitz SD, Chan AT. Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med 2014;6:233re2. # # Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology – integrated analysis of host and tumor factors for personalized medicine . Nat Rev Clin Oncol 2011:8:711-719. # # Ogino S, King EE, Beck AH, Sherman ME, Milner DA, Giovannucci E. Interdisciplinary education to integrate pathology and epidemiology Towards molecular and population-level health science . Am J Epidemiol 2012;176:659-667. # # Ogino S, Giovannucci E. Lifestyle factors and colorectal cancer microsatellite instability – Molecular pathological epidemiology science, based on unique tumour principle . Int J Epidemiol 2012;41:1072-1074. # # Ogino S, Fuchs CS, Giovannucci E. How many molecular subtypes? Implications of the unique tumor principle in personalized medicine . Expert Rev Mol Diagn 2012;12:621-628. # # Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E (April 2013). "Molecular pathological epidemiology of epigenetics emerging integrative science to analyze environment, host, and disease". Modern Pathology 26 (4) 465–84. # # Field AE, Camargo Jr CA, Ogino S. The merits of subtyping obesity one size does not fit all . JAMA 2013;310:2147-2148. # # Ogino S, Lochhead P, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT. Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker power and promise of molecular pathological epidemiology review. Oncogene 2014;33:2949-2955. # # Lochhead P, Chan AT, Nishihara R, Fuchs CS, Beck AH, Giovannucci E, Ogino S. Etiologic field effect reappraisal of the field effect concept in cancer predisposition and progression review. Mod Pathol in press (published online). # # Lochhead P, Chan AT, Giovannucci E, Fuchs CS, Wu K, Nishihara R, O’Brien M, Ogino S. Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions . Am J Gastroenterol 2014;109(8):1205-1214. # # Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012;367:1596-1606. # # Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, Inamura K, Kim SA, Kuchiba A, Yamauchi M, Imamura Y, Willett WC, Rosner BA, Fuchs CS, Giovannucci E, Ogino S, Chan AT. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med 2013;369:1095-1105. # # The Ogino MPE lab ( http://ogino-mpe-lab.dana-farber.org ) # Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer. 2002;101:403–8. # # Gervaz P, Bucher P, Morel P. Two colons-two cancers paradigm shift and clinical implications. J Surg Oncol. 2004;88:261–6. # # Carethers JM. One colon lumen but two organs. Gastroenterology. 2011;141:411–2. # # Albuquerque C, Bakker ER, van Veelen W, et al. Colorectal cancers choosing sides. Biochim Biophys Acta. 2011;1816:219–31. # # Yamauchi M, Lochhead P, Morikawa T, Huttenhower C, Chan AT, Giovannucci E, Fuchs C, Ogino S. Colorectal cancer a tale of two sides or a continuum? Gut. 2012 Jun;61(6):794-7. # # Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, Liao X, Waldron L, Hoshida Y, Huttenhower C, Chan AT, Giovannucci E, Fuchs CS, Ogino S. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 2012;61:847-854. PMCID:PMC3345105 # # Jess P, Hansen IO, Gamborg M, Jess T; Danish Colorectal Cancer Group. A nationwide Danish cohort study challenging the categorisation into right-sided and left-sided colon cancer. BMJ Open. 2013 May 28;3(5). # # Papagiorgis P. Colorectal cancer dichotomous or continuum model? Perhaps, a combination of both. Gut. 2013 Oct;62(10):1519-20. # # Ogino S, Chan AT, Fuchs CS, Giovannucci E. Gut. 2011 Mar;60(3):397-411. doi 10.1136/gut.2010.217182. Epub 2010 Oct 29. Review. PMID 21036793 Molecular pathological epidemiology of colorectal neoplasia an emerging transdisciplinary and interdisciplinary field. # # Ogino S, Fuchs CS, Giovannucci E. Expert Rev Mol Diagn. 2012 Jul;12(6):621-8. doi 10.1586/erm.12.46. Review. PMID 22845482 How many molecular subtypes? Implications of the unique tumor principle in personalized medicine. # # Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E. Mod Pathol. 2013 Apr;26(4):465-84. doi 10.1038/modpathol.2012.214. Epub 2013 Jan 11. Review. PMID 23307060 Molecular pathological epidemiology of epigenetics emerging integrative science to analyze environment, host, and disease. # # Lochhead P, Chan AT, Nishihara R, Fuchs CS, Beck AH, Giovannucci E, Ogino S. Mod Pathol. 2014 Jun 13. doi 10.1038/modpathol.2014.81. Epub ahead of print PMID 24925058 Etiologic field effect reappraisal of the field effect concept in cancer predisposition and progression. # # The world’s Most Influential Minds:2014 (https://web.archive.org/web/20141007000116/http://thomsonreuters.com/articles/2014/worlds-most-influential-scientific-minds-2014) Thomson Reuter. Retrieved September 5, 2014. # # http://www.faseb.org/About-FASEB/Who-We-Are/Governance/Board-Ordinary-Committees.aspx Retrieved September 15, 2014. The Ogino MPE lab Dana-Farber/ Harvard Cancer Center faculty profile Harvard School of Public Health faculty profile Brigham & Women’s Hospital faculty profile Brigham & Women’s Hospital, Department Pathology faculty profile 분류:1968년 태어남 분류:살아있는 사람 분류:일본의 병리학자 분류:역학자 분류:도쿄 대학 동문 분류:하버드 대학교 동문 분류:하버드 대학교 교수