cyrilzakka/clinical-trials huggingface dataset:
Assessment of Biomarkers in Children to Help Parents Quit Tobacco

This randomized controlled trial will test whether adding biomarker measurement and informed outreach for tobacco smoke exposure as part of routine practice increases identification and improves treatment, effectiveness, and sustainability of a parental tobacco control intervention that will be integrated into pediatric practice.

This trial will examine the effectiveness of systematic cotinine testing of children 12 years old or younger using blood already collected at any visit to a practice that sees pediatric patients where there is a clinically indicated blood draw. We hypothesize that providing cotinine biomarker results to pediatricians, personalized cotinine feedback to parents about their child's toxin exposure, and offering support to all household tobacco users to quit tobacco use (Biomarker Informed Outreach (BIO)) when added to the Clinical Effort Against Secondhand Smoke Exposure (CEASE) intervention will increase delivery of tobacco cessation assistance, increase household cessation, reduce tobacco smoke exposure in children, and be cost-effective. This is a 2-arm randomized controlled trial with family-level randomization to either CEASE+BIO or CEASE arms at the time of the child's baseline visit. To compare the effectiveness of CEASE+BIO vs. CEASE, we will follow-up with enrolled parents 12 months later to assess parental quit rate and children's tobacco smoke exposure.

Eligibility Criteria:
Inclusion Criteria:

1. Child 12 years old or younger presenting for a visit.
2. Child scheduled for or has had a clinically indicated blood draw at that visit
3. Parent/legal guardian of the child.
4. Parent/legal guardian is a current smoker (past 7 days).

Exclusion Criteria:

1. Parent/legal guardian is non-English speaking.
2. Parent/legal guardian is less than 18 years of age.
Evaluation of the Impact of a HPV Vaccination Talk with Third Grade Students

This is a prospective pragmatic study to assess the impact of a HPV vaccination talk in secondary school on actual vaccine dispensing in test communes compared with control communes. The talk consist on a briefing on the importance of vaccination.

This is a controlled study, since two communes will benefit from the HPV vaccination talk, while the other two will serve as controls without set up of the HPV vaccination talk. The set up of this presentation will be open-label.

The main aim of the present study is to investigate the impact of HPV vaccination talk with 3rd grade school children on HPV vaccine dispensing by making them actors in their own health. A significant benefit on vaccination coverage is expected. In addition, a flyer providing information and raising awareness of infections and the benefits of HPV vaccination will be sent to parents at the end of the talk.

Eligibility Criteria:
Inclusion Criteria:

* 3rd grade students enrolled in public secondary schools in Suresnes and Rueil-Malmaison.

Exclusion Criteria:

* Students absent on the day of the talk.
* Students unwilling/unable to complete questionnaire.
Telerehabilitation in Women With Rheumatic Disease

This study aims to investigate the effectiveness of the Biopsychosocial Exercise Therapy Approach (BETY), which is a biopsychosocial model, on daily living activities, anxiety, depression, and biopsychosocial conditions through telerehabilitation in rheumatic patients who could not go to the clinics during the COVID-19 pandemic.

35 female participants with rheumatic disease were included in the study. Among the individuals who participated in face-to-face BETY sessions before, 23 individuals who agreed to exercise with telerehabilitation were divided into 2 groups, the exercise group, and 12 individuals in the control group.

Group 1: Telerehabilitation group: Individuals in the telerehabilitation group attended sessions that lasted for one and a half hours, 3 days a week for 8 weeks, in the company of a physiotherapist over the Whatsapp group. The investigators, who provided supervision during the sessions, also participated in the exercises simultaneously. The investigators managed the individuals according to their exercise number and order, by reminding them of the exercises with explanatory messages and positive energy via Whatsapp group. The participation of the patients in the exercises was followed up with the answers they gave in the Whatsapp group. Patients who did not respond were called by phone and checked to see if they provided continuity. Both the exercise group and the control group continued their drug treatments during this period.

Group 2: Control group: Individuals in the control group continued their routine drugs.

Eligibility Criteria:
Inclusion Criteria:

* Participants diagnosed with rheumatic disease,
* Participants knew the exercises before attending BETY sessions,
* Participants who could participate in telerehabilitation by following WhatsApp communication were included in the exercise group.

Exclusion Criteria:

* Participants with neurological and psychological disorders,
* severe respiratory failure, fractures, infections, cancer, and musculoskeletal pain due to surgery in the last 6 months,
* Vision loss,
* Pregnancy
* Participants who did not agree to volunteer were not included in our study.
Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery

Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).


Eligibility Criteria:
Inclusion Criteria:

1. The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer
2. Adults above 20 years of age and providing informed consent.
3. American Society of Anesthesiologists (ASA) Physical class II, \& III patients

Exclusion Criteria:

1. severe functional liver or kidney disease
2. history of chronic pain requiring opioid treatment
3. arrhythmia or received treatment with antiarrythmic drug .
4. severe bradycardia (HR \< 45 bpm) and AV block
5. pathologic esophageal lesion (esophageal stricture or varix )
6. pregnancy
7. psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
8. History of alcohol or drug abuse
Crossover RCT of TAMER Lenses in Myopia Control

This study is a prospective, randomized, crossover clinical trial with a planned proposed enrollment of 120 Chinese male and female subjects aged 6-12 years without systemic or ocular diseases to follow up their cycloplegic equivalent spherical lens power and other relevant indices in order to determine the role of TAMER lenses in myopia control as compared to singlie vision lenses.


Eligibility Criteria:
Inclusion Criteria:

* Race: Chinese children and adolescents.
* Age 6-12 years, gender unrestricted.
* Cycloplegic refraction SER: -0.75DS\~-5.0DS in both eyes.
* Best corrected visual acuity of both eyes reaches 0.8 (0.00 logMAR).
* Cylinder power and astigmatism are no more than 1.5D.
* During the study period, willing to wear glasses provided by the researcher only and without additional interventions.
* Willing to be randomly assigned.
* Able to sign an informed consent form with the accompaniment and understanding of parents or guardians.

Exclusion Criteria:

* Allergic or intolerant to medications used for cycloplegia.
* Received any nearsightedness treatment such as atropine, rigid gas permeable contact lens, bifocal/progressive lens, red light therapy, or acupuncture within half a year before the study.
* Diagnosed with any eye disease other than nearsightedness, including strabismus, corneal diseases, conjunctival or eyelid damage or other conditions (such as keratoconus, herpes simplex keratitis, etc.).
* History of eye surgery (including strabismus correction surgery).
* Eye or systemic diseases that might be associated with nearsightedness or its progression, such as Marfan syndrome, retinopathy of prematurity, diabetes, etc.
* Anatomical or dermatological factors that may interfere with the wearing of spectacle frames.
* Other reasons that the researcher deems inappropriate for the participant to be included in the study, such as excessively high expectations for the effectiveness of defocus lenses, or plans to use other nearsightedness intervention strategies simultaneously with the study.
The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia

Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. 74% of awakenings from REM sleep resulted in recall of a dream, as compared with only 9% of awakenings from NREM sleep. The association between dreaming and REM sleep was subsequently replicated by many other investigators; typically, around 80% of REM awakenings yield dreams. It became clear over time that there is a good deal of mental activity that occurs during NREM sleep. Typically, it is more thought like, fragmentary, and related to daily concerns than the vivid, hallucinatory, predominantly visual narratives that are most commonly reported from REM sleep. But even this distinction appears not to be absolute. There is now wide acceptance of the view that some dreaming that is indistinguishable from REM sleep dreaming occurs in NREM sleep, most frequently in the sleep-onset period. General anesthesia causes a drug-induced state of unconsciousness and is a non-physiological process that is similar to natural sleep. Patients receiving propofol for maintenance of general anesthesia often report higher incidences of dreaming than patients maintained with volatile anesthetics. One explanation is that propofol and volatile anesthetic have different pharmacological effects in the central nervous system. An alternative explanation is that propofol is associated with more rapid emergence from anesthesia than the older volatile anesthetics, allowing patients to report their dreams before they are forgotten. In order to further verify the hypothesis, the investigators choose gynecological general anesthesia to observe whether the generation of dreams is related to the dose of general anesthesia maintenance .


Eligibility Criteria:
Inclusion Criteria:

* between 18 and 70 years
* with an ASA physical status of I or II

Exclusion Criteria:

* presence of sleep disorders
* pain syndrome
* cardiovascular disease
* sleep apnea syndrome
* psychosis
* history of opioid usage
* history of abnormal operation or anesthesia recovery
* unwillingness to provide informed consent
* a patient with a language communication disorder
Renal Function Determination in Patients With Liver Cirrhosis

We have several ways to appropriately determine renal function in healthy patients and in several diseases, in cirrhotic population we dont have a precise tool that has sufficient precision that reflects glomerular function, although it has been reported that cystatin C, because of its nature could improve diagnostic accuracy to determinate the renal function in this population.

The investigators hypothesize that glomerular filtration obtained from cystatin-C-derived formulas are more accurate when compared to creatinine-derived formulas with DTPA-Tc99 (diethylene-triamine-pentaacetate- technetium-99) as gold standard.

The aim of the study is to determine if the formulas for glomerular filtration are close to the estimation of actual renal function in mexican cirrhotic patients of different etiologies.

Eligibility Criteria:
Inclusion Criteria:

* Liver cirrhosis
* Stability in creatinine levels in the previous three months (variation \<0.3 mg/dL)
* Signed informed consent

Exclusion Criteria:

* Pregnancy
* Hepatocellular carcinoma
* Cerebrovascular events
* Decompensated heart failure
* Drugs that modify serum creatinine levels
* Renal replacement therapy
Morphological Detection of Liquid-based Thin-layer Film-making Fungi for Fungal Vaginitis in Multiple Hospitals

The purpose of this study is to compare the results of different detection methods for non-gestational fungal vaginitis (VVC), and to evaluate the significance of different fungal states in the results for diagnosis and treatment.

The study was divided into two phases: in the first phase, the vaginal secretions of 1000 enrolled patients with fungal vaginitis were detected with 3/4 different methods, and the sensitivity, specificity and consistency of these methods were compared; In the second stage, 1000 patients from the first stage were selected to meet the follow-up stage and divided into two groups. The test of Follow-up fungal culture and fluorescence morphological detection of liquid-based thin-layer film-making fungi were performed periodically. At last, the applicant will analyze the data, write the paper and publish the article.

Eligibility Criteria:
Inclusion Criteria:

* 1. Samples from outpatient or inpatient clinics to be tested for fungal vaginitis.
* 2. A sample of one or more of the following characteristics. 2.1 Symptoms: vulva pruritus, burning pain, but also accompanied by pain in urine and sexual pain and other symptoms; Leucorrhea increased.

2.2 Physical signs: Vulva flushing, edema, visible scratches or chaps, white membrane attached to the inner side of the labia minora and the vaginal mucosa, more white bean residue like secretions can be seen in the vagina, which can be curd.

* 3. The samples are vaginal secretions from the female body. Each sample should be the amount on one swab.
* 4. The sample is not in menstrual period.
* 5. The sample subjects did not have vaginal irrigation, medication or sexual intercourse within 3 days.

Exclusion Criteria:

* 1. Cases with incomplete specimen collection;
* 2. Mixed vaginitis cases;
* 3. Abscission cases with incomplete follow-up.
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.

The purpose of this project is to advance mechanistic knowledge of how stress impacts differential opioid analgesic responses that enhance risk for opioid use disorder (OUD), potentially informing development of data-driven precision pain medicine algorithms to mitigate opioid related risks.

The study aims to determine whether subjective and physiological stress-related measures are associated with analgesic and misuse-relevant subjective responses to placebo-controlled oxycodone administration. The study also aims to evaluate associations between stress-related measures and both endogenous opioid (EO) function and endocannabinoid (EC) levels and to test whether EO and EC mechanisms contribute to associations between stress-related measures and oxycodone responses

Using a mixed between/within-subject design, the study will obtain baseline assessment of stress related markers followed by 3 laboratory sessions with assessment of endocannabinoids, back pain assessment, and exposure to standardized evoked pain stimuli after administration of placebo, naloxone, and oxycodone.

Eligibility Criteria:
Inclusion Criteria:

* Intact cognitive status and ability to provide informed consent
* Ability to read and write in English sufficiently to understand and complete study questionnaires (which are only validated in English)
* Age 18 or older And
* Presence of persistent daily low back pain of at least three months duration and of at least a 3/10 in average intensity

Exclusion Criteria:

* History of renal or hepatic dysfunction
* Reports of current or past alcohol or substance abuse or treatment for such condition
* A reported history of PTSD, psychotic, or bipolar disorders
* Chronic pain due to malignancy (e.g., cancer) or autoimmune disorders (e.g., rheumatoid arthritis, lupus)
* Reports of recent benzodiazepine use (confirmed via rapid urine screening prior to each lab session)
* Any medical conditions (e.g., significant cardiovascular disease) that the study physician feels would contraindicate participation in the lab stressors
* Reported daily opiate use within the past 6 months, or use of any opioid analgesic medications within 3 days of study participation (confirmed through rapid urine screening prior to each lab session)
* Pregnancy (females only, to avoid fetal drug exposure - pregnancy tests conducted prior to each lab session to confirm eligibility)
* Prior allergic reaction/intolerance to oxycodone or its analogs
Screening of Instability of the Spinal Column With Spinal Mouse® and X-ray

The SpinalMouse is a computer-assisted medical device that measures and graphically reports on posture and range of motion of the axial spine. The data has shown to be highly valid and reproducible while compared to x-ray film. The aim of the study is to evaluate if the Spinal Mouse is a reliable clinical diagnostic device to screen those patients having instability in the lumbar area.


Eligibility Criteria:
Inclusion Criteria:

* supposed instability of lumbar spine

Exclusion Criteria:

* not willing to participate to study
Comparison of Unilateral CI vs. Bimodal Stimulation in Prosodic Perception

An observational study to determine and assess perception of prosodic information in adults who use bimodal stimulation (cochlear implant plus hearing aid) when using both devices vs. cochlear implant alone.

People with severe to profound hearing loss often do not get satisfactory benefit from their hearing aids. A cochlear implant (CI) is a prosthetic device for the inner ear which can directly stimulate the auditory nerve, bypassing damaged inner ear hair cells and thus provide audible sensations to profoundly deaf patients.

Currently, one CI is funded by NHS England for adult patients and the eligibility criteria for implantation has been relaxed in recent years. As a result, there are now an increasing number of unilateral CI users who possess low-frequency residual hearing in their non-implanted ear. For many patients this residual hearing may still be usefully amplified by a HA. This configuration, consisting of a CI and a contralateral HA, is known as bimodal stimulation.

The PEPS-C receptive test battery has been previously used to assess prosody perception in hearing loss.

The current project will use selected tests from the PEPS-C prosodic test battery to assess intonation, emotion and phrase stress perception ability in adults with bimodal stimulation using both devices together and CI alone.

Eligibility Criteria:
Inclusion Criteria:

* Adult
* Has unilateral Cochlear Implant
* Consistent use of Hearing Aid
* Obtains some benefit in speech discrimination from hearing aid (\> 20% AB words)
* Post-lingually deafened
* Fluent English

Exclusion Criteria:

* Longstanding significant asymmetry (\> 20 dB HL 4 frequency average) in hearing where the unimplanted ear is the worse ear
* Inconsistent Hearing Aid use
* Significant conductive hearing loss (\> 20 dB HL 4 frequency average)
* Using Electro-Acoustic stimulation Cochlear Implant
* Aetiology of hearing loss likely associated with auditory neuropathy
* Significantly abnormal appearance of cochlea or cochlear nerve
Hamate Hook Removal, Microscrew Internal Fixation and Plaster Fixation for the Treatment of Hamate Hook Fractures

To compare the effects of hamate hook removal, microscrew internal fixation and plaster fixation on fracture healing, work, life, and exercise recovery in patients with hamate hook fractures by retrospective case analysis.

Hamate hook fractures are rare, and mainly occur during sports activities. Its projection is often obscured by other carpal bone in conventional X-ray plain films, so hamate hook fractures are the most easily missed injury in hand surgery. As the incidence of such fractures is too small, it brings some difficulties in the clinical choice of correct and effective treatment. Currently, treatment programs of hamate hook fractures also are not consistent.

Eligibility Criteria:
Inclusion Criteria:

* Hamate hook fractures finally diagnosed by X-ray and CT scan at the wrist position holding a cup and the carpal canal position (appendix 2)
* Unilateral hamate hook fractures
* Irrespective of age and sex

Exclusion Criteria:

* Incomplete follow-up data
Relationships Between Physical Activity and Different Measures of Fatigue in Cancer Survivors

This is an investigation of possible relationships between daily physical activity (PA) and different measurements of fatigue in cancer survivors participating in a cancer exercise program.

This is an investigation of possible relationships between daily physical activity (PA) and different measurements of fatigue in cancer survivors participating in a cancer exercise program. Results will inform exercise prescription and timing to best reduce fatigue, as well as methodology for measuring fatigue. Participants will answer several daily questions on fatigue using a smartphone application during the 3 month exercise program and wear a PA monitor for 10 days during the first month and last month of the program.

Eligibility Criteria:
Inclusion Criteria:

* Be an active participant in the BfitBwell Cancer Exercise Program
* Criteria for this program include:
* Adult (\>= 18 years old)
* Being a patient seen at the University of Colorado Cancer Center
* Currently receiving cancer therapy or be within 6 months of completing cancer therapy
* Have a signed physician clearance form to participate in an exercise program
* Have a smartphone (necessary for the EMA assessments)
* A score of 48 or less on the FACIT-Fatigue (completed during the initial BfitBwell Program assessment)
* The minimally important difference of the FACIT-Fatigue is 3 points, suggesting that a score of at most 48 indicates the presence of CRF and allows for meaningful change in both directions.

Exclusion Criteria:

* None
Simulator Training for Direct Ophthalmoscopy

Evaluation of a digital simulator to train diagnostic skills in Ophthalmology

Direct Ophthalmoscopy is an important tool to detect pathologies e.g. on the optic nerve head. The training of the needed skills is made conventionally in most cases. In such the training sessions students examine each other after dilating one pupil. Examining of patients with pathologies is very important, but in many cases not very easy without any experience.

Simulators are of growing impact to teach diagnostic or surgical skills. A digital simulator with virtual reality technology is used to teach the skills to unexperienced examiners. The head-eye-hand-coordination can be trained without any stress.

Eligibility Criteria:
Inclusion Criteria:

* Medical student or Ophthalmologist or Neonatologist or Neurologist or Neurosurgeon
* Willing to participate to the study
* Consent to evaluate the measured data

Exclusion Criteria:

* age \<18 years
The Safety of Cataract Removal by Phacoemulsification Surgery in Patients Under Anti-aggregant and Coumadin Treatment

To assess the risks of intra- and postoperative bleeding tendency associated with cataract surgery by phacoemulsification in patients on coumadin and antiaggregant treatments.

Design: Consecutive prospective study.

To assess the risks of intra- and postoperative bleeding tendency associated with cataract surgery by phacoemulsification technique in patients on coumadin and antiaggregant treatment Design: Consecutive prospective study.

Eligibility Criteria:
Inclusion Criteria:

* patients who give informed consent to participate in the study

Exclusion Criteria:

* single eye complicated cataract