cyrilzakka/clinical-trials huggingface dataset:
Intraoperative Video Laryngoscopy as Adjunct for Nerve Monitoring

The purpose of this study is to describe the impact of adding intraoperative video laryngoscopy (IOVL) to intraoperative laryngeal nerve monitoring (IOLNM) during neck procedures when IOLNM is routinely used, including thyroidectomy and re-operative parathyroidectomy. Specifically, the study team seeks to assess how frequently the use of IOVL provided confirmatory or additional information that may affect surgeon decision-making when IOLNM alone is ambiguous, or when there is equipment malfunction or failure. The IOVL is a disposable, otherwise standard fiberoptic laryngoscope (Larynxview, Neurovision Medical, Ventura CA) that is inserted alongside the endotracheal tube following intubation for surgical procedures. It allows assessment of vocal cord movement in response to nerve stimulation. Currently, the use of IOLNM is based on audio cues, and visual assessment of external laryngeal muscle movement during surgery in response to stimulation, but no direct assessment of vocal cord movement is routinely possible. This information can be ambiguous and subject to judgement of the surgeon. The addition of IOVL provides direct assessment to vocal cord movement in response to stimulus, and may be useful in light of ambiguous IOLNM data, or limited visualization of external laryngeal muscles.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 and older with capacity to make all medical decisions
* Medical indication for partial or total thyroidectomy, re-operative parathyroidectomy, or neck dissection

Exclusion Criteria:

* Patients who are under the age of 18
* Patients who are not able to make medical decisions or consent to research
Value of Renal Vascular Doppler Sonography in Management of Decompensated Heart Failure

Although the traditional determinant of renal dysfunction in heart failure was suggested as decreased cardiac output and renal hypo perfusion, recent studies have demonstrated the association of persistent systemic venous congestion and kidney dysfunction. Relief of the congestion has demonstrated to improve renal functions in decompensated heart failure. The current trial was set up to investigate the changes of renal venous impedance and renal arteriolar resistivity indices with diuretic therapy, in patients with congestive renal failure. The investigators asked whether measurement of renal venous impedance index or renal arteriolar resistivity index can guide the practice of diuretic therapy.


Eligibility Criteria:
Inclusion Criteria:

* Decompensated heart failure
* Elevated serum creatinine levels on admission

Exclusion Criteria:

* Atrial fibrillation
* Obstructive uropathy
* Patients with ascites
* Patients who exposed the potential nephrotoxic drugs in the previous week (metformin, antibiotics, chemotherapeutics, iodinated contrast agents and non-steroidal anti-inflammatory agents)
* Patients who needed positive inotropic agents
CCSV - Post Market Clinical Follow-up Study

The main goal of this observational study is the evaluation of Chest Compression Synchronized Ventilation (CCSV) regarding oxygenation in terms of PaO2 assessed by routine blood gas analysis, hemodynamic effects, 30-day outcome and safety in comparison to Intermittent Positive Pressure Ventilation (IPPV) as data in humans is sparse especially in direct comparison to other ventilation modes.

Cardiac arrest patients in Vienna, Austria will be preclinically randomized (IPPV and CCSV) and ventilated accordingly during CPR. Differences in oxygenation, decarboxylation, systemic perfusion and cerebral oxygenation, the patient's 30-day outcome as well as ventilator-associated adverse events (e.g., pneumothorax) will be recorded and analyzed.


Eligibility Criteria:
Inclusion Criteria:

* OHCA
* Correct endotracheal intubation (seen by capnography)
* The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation.
* MEDUMAT Standard from Weinmann Emergency is used.
* Mechanical ventilation is performed according to the specified indications.

Exclusion Criteria:

* Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna)
* Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it
* Any other mechanical ventilation during the ongoing CPR before study inclusion
* Traumatic cardiac arrest
* Suspected or known pregnancy
* Clinically suspected (tension-)pneumothorax
Terrorist Attack - Continuity of Care

On November 13th 2015, a terrorist attack killed 129 victims in Paris. An emergency crisis unit (CUMP) has been activated in Paris in the days following the attack and a subunit was in charge to answer to the phone calls of victims and their relatives. The same emergency crisis unit have been activated for the terrorist attack in London, 2017 june 3, terrorist attack in Barcelone 2017 august 17-18, terrorist attack in Strasbourg 2018 December 11 The purpose of this observational study is to document the evolution of psychiatric symptoms among subjects who called the CUMP and to collect information about the type of medical or non-medical care they were seeking for.

The care of the victims of natural disasters or mass disasters such as terrorist attacks is now better structured and organized. The efficacy of debriefing or of defusing has been and is still debated, sometimes bitterly. The aim of the present study is not to demonstrate utility or futility of such approaches, but to i) evaluate their global improvement over the past three years. ii) to list the type of support that the victims were seeking in their attempt to get rid of the symptoms which appeared after the terrorist attack of November 2015 in Paris.

iii) to collect their opinions about the way the CUMP (emergency medico-psychological unit of Paris, France) managed the support to the victims.

Participating subjects registered on the occasion of their first contact with the CUMP 75 by phone during the week following the attack

Eligibility Criteria:
Inclusion Criteria:

- All subjects who called the CUMP of Paris between November 13th, 2015 and January 31st, 2016; London 11th,2017 ; Barcelone 17-18th, 2017 ; Strasbourg 11th, 2018 and completed the questionnaire.

Exclusion Criteria:

- Subjects who did not consent to their participation to the study.
Impact of Hemodialysis on Plasma Carnitine Levels in Patients With End Stage Renal Disease

OBJECTIVES

* To assess the levels of plasma carnitine in controls and hemodialysis patients.
* To give supplementary L-carnitine to study subjects for a duration of 5months.
* To compare the values of plasma carnitine before and after L carnitine supplementation.
* To assess the role of carnitine supplementation on biochemical and clinical parameters.

.ABSTRACT INTRODUCTION Dialysis therapy can cause a decrease in both free carnitine and plasma acyl carnitines after only six months of dialysis treatment. A positive correlation between AC/FC ratio and months on HD therapy has been reported. We investigate in this study the role of oral L-carnitine supplementation on anemia, blood pressure, cardiac dysfunction and muscle cramps in hemodialysis patients.

OBJECTIVES

* To assess the levels of plasma carnitine in controls and hemodialysis patients.
* To give supplementary L-carnitine to study subjects for a duration of 5months.
* To compare the values of plasma carnitine before and after L carnitine supplementation.
* To assess the role of carnitine supplementation on biochemical and clinical parameters.

STUDY DESIGN AND SETTING: It will be a case-control study, which will be conducted in the Department of Biochemistry, University of Karachi in collaboration with Nephrology ward of JPMC, Karachi in a period of one year after approval of synopsis.

METHOD: Total 120 subjects will be included in this study which will be divided into two groups. Group A will comprise of 60 subjects of Chronic renal failure who will be the control group. Group B will comprise of 60 subjects who will be on hemodialysis for more than 1 year. Blood samples will be taken after informed consent. Group B subjects will be given L-Carnitine supplementation for five months under strict monitoring. Physical, biochemical and clinical parameters of group B subjects will be compared before and after supplementation.

RESULTS: Data will be analyzed using SPSS version 21. Results will be shared after completion of research.

CONCLUSION: conclusion will be shared after completion of research.

Eligibility Criteria:
Inclusion Criteria: • Individuals of either sex (male and female).

* The study included people between the ages of 18 and 50 who had had dialysis for more than two years without taking additional antioxidants.

Exclusion Criteria:

* • Individuals with any other chronic ailment, such as cancer or tuberculosis.

  * Patients with acute renal failure who are receiving hemodialysis.
  * All subjects who refused to take part in the investigation.
Comparing the Therapeutic Efficacy and Safety of DA-9701 With Domperidone in Patients With Parkinson's Disease

This study will evaluate the therapeutic efficacy and safety of DA-9701 with domperidone in patients with Parkinson's disease

To prevent nausea and vomiting induced by anti-parkinsonian drugs, prokinetic drugs are frequently prescribed in patients with Parkinson's disease (PD). Additionally, there has been some evidence that prokinetics might improve PD symptom fluctuations. From this background, the investigators will evaluate the therapeutic efficacy and safety of DA-9701 in PD patients.

In this study, 40 patients will be enrolled and randomly allocated 1:1 to receive either domperidone or DA-9701. The gastric function of each study participant will be evaluated using the MRI technique before and after 4 weeks of the treatment. The study participants will also be subjected to complete the gastrointestinal symptom diary before and during the treatment period. In addition, plasma levodopa concentrations will be determined 30 minutes after dose administration before and after treatment.

Eligibility Criteria:
Inclusion Criteria:

* subjects diagnosed with spontaneous parkinsonism by the United Kingdom(UK) Parkinson's Disease Society Brain Bank criteria
* subjects who are able to explain symptoms they experience and to complete relevant assessment and exams including questionaires
* subjects who understand the purpose and protocols of the study and agree to participate on the study

Exclusion Criteria:

* subjects who experience psychiatrical disorders such as cognitive or behavioral disorders
* subjects who are on prokinetics or who are unable to cease such medication
* subjects who present neurological disorders which influence gastrointestinal mobility
* subjects who present gastrointestinal conditions which influence gastrointestinal mobility
* subjects with a history of gastrectomy or colectomy
* subjects who are unable to receive and complete the course of medication due to other metabolic disorders
* subjects diagnosed with parkinson plus syndrome
* subjects who are unable to undergo MRI scan for safety reasons due to claustrophobia or certain devices such as cardiac pacemakers or aneurysm clips
Autologous Regenerative Islet Transplantation for Insulin-dependent Diabetes

This is a single-center, phase IIT clinical trial to evaluate autologous regenerative islet transplantation for insulin-dependent diabetes mellitus.

Twenty patients with insulin-dependent diabetes mellitus will be enrolled: poor blood glucose control despite intensive exogenous insulin therapy. The primary endpoint will be defined by the return to normal blood glucose control without insulin at 12 months after transplantation.


Eligibility Criteria:
Inclusion Criteria:

* Insulin-dependent diabetes mellitus, the specific criteria are (1 of 4-6 is sufficient).

  1. Age: 18-70 years old;
  2. History of diabetes mellitus \>1 year;
  3. Insulin-dependent and total daily insulin dose \>20 units;
  4. Poor blood glucose control despite intensive exogenous insulin therapy (or high blood glucose fluctuation, glycation \>8% );
  5. Frequent hypoglycemic episodes with unconsciousness; 6) Diabetic nephropathy, patients who need to receive kidney transplantation.

Exclusion Criteria:

* 1) Severe heart disease; 2) Severe mental disorders, poor compliance or alcohol abuse; 3) Active infection or with malignancy; 4) Weight greater than 25% of ideal weight; 5) Evidence of endogenous insulin secretion, such as type 2 diabetes; 6) Smoking; 7) During gestation or preparation for gestation.
Comparison of Interventions in Patients With Carpal Tunnel Syndrome

This study aims to compare two types of intervention (stretching and myofascial manipulation) in the treatment of individuals with bilateral idiopathic carpal tunnel syndrome. This comparison applies to two groups, the clinical group is composed of patients of mild or moderate degree, whereas the surgical group is composed of a patient with at least one hand in severe degree and interventions are made after surgery.

Using clinical criteria and ENMG, individuals will be divided into a clinical group when they have a mild and / or moderate degree of involvement in the hands and a surgical group when the impairment intensity is severe in at least one hand.

The individuals in the clinical group will be randomized into two groups, with one group starting with stretching and a second group starting with hook-assisted myofascial manipulation. After four weeks of initial therapy and one week of wash-out the assessment tests described above will be applied. The groups will be inverted, maintaining the duration and frequency of the previous stage of the proposed therapies. After four weeks with a week of wash-out the tests will be reapplied in order to evaluate the therapeutic response.

Individuals with severe idiopathic CTS will undergo surgery using a standard open technique with local anesthesia and after four weeks, randomization will be made for postoperative treatment on both hands by stretching or myofascial manipulation in the same manner described for the clinical group.

Questionnaires will be applied in order to understand the patient's symptoms, functions, pain and quality of life. In addition, tests will be used to assess hand strength, sensitivity and hand ability.

Eligibility Criteria:
Inclusion Criteria:

* bilateral idiopathic CTS above six months of symptomatology;
* with clinical criteria and ENMG for indication of clinical or surgical treatment;
* who have no history of gabapentin allergy.

Exclusion Criteria:

* Individuals with CTS for other reasons, such as pregnancy, arthritis, hypothyroidism, diabetes mellitus, trauma, expansive tunnel damage, amyloids, sarcoidosis, multiple myeloma, and leukemia.
* Individuals with conditions that can simulate CTS, such as carpometacarpal thumb arthritis, cervical radiculopathy mainly of the sixth cervical root level, radial flexor carpal tenosynovitis and central disorders such as multiple sclerosis and cerebral infarction.
Influence of Supportive Sandals on Y-Balance Performance on Healthy Young Individuals

The Y-balance test is a lower extremity, dynamic test performed in single limb stance that measures a person's ability to reach in 3 directions. The test is typically conducted in barefoot. The purpose of this study is to assess the impact of footwear on Y-Balance test scores. The investigators hypothesize that by improving alignment and augmenting muscle mechanics, sandals with medial arch support may improve Y-Balance scores.


Eligibility Criteria:
Inclusion Criteria:

* Men or Women between the ages of 21 to 40 years, inclusive
* Grossly intact and symmetrical neuromuscular status
* Able to ambulate without difficult or pain
* Able to understand the information in the informed consent form
* willing and able to sign informed consent form

Exclusion Criteria:

* history of ankle sprain, Anterior cruciate ligament injury; recent hip, knee, foot or ankle pain within past 6 months
* Uncontrolled Heart (Hypertension; BP \>= 140/90), Lung Disease (uncontrolled asthma or shortness of breath), or diabetes
* Nursing or pregnant
* Not willing or able to follow procedures specified by protocol and/or instructions of the study personnel
* Unable to fit into available shoe sizes
EFFECTIVENESS OF GRADED MOTOR IMAGERY TO PREVENT CRPS IN PATIENTS WITH DISTAL RADIUS FRACTURE AFTER SURGERY

The study would like show that patients who follow a protocol with GMI are less probability to develop CRPS

Distal radius fractures (DRF) has a high frequency in adults. Studies show that the upper limb is frequently affected by CRPS, especially if is preceded by a fracture.

Recent studies suggest that changes in cortical structures can contribute to the onset of CRPS.

GMI is a approved and efficacy method in CRPS rehabilitation, because it trains modified cortical areas throught 3 stadies: left-right discrimination, visual motor imagery and mirror therapy.

Literature shows that there are any studies about GMI efficacy on prevention CRPS in DRF after surgery.

This study would like to demostrate that, appling GMI in the early stages of rehabilitation plus standard rehabilitation protocol of DRF after surgery, CRPS cases are reducted.

Eligibility Criteria:
Inclusion Criteria:

* Patients with distal radius fracture after surgery
* 18 to 75 years old
* Male and female

Exclusion Criteria:

* uncompliants patients
* patients with neurological disorders or cognitive impairment
* patients with TFCC injury or both ulna and radius fractures
* patients with visually impairment
* patients who don't speak or understand oral and written italian language
The Effect of Mobilized Stem Cell by G-CSF and VEGF Gene Therapy in Patients With Stable Severe Angina Pectoris

The aim of this study was to evaluate the mobilization of non-haematopoietic mesenchymal and haematopoietic stem cells from the bone marrow with granulocyte colony stimulating factor (G-CSF) treatment alone and in combination with vascular endothelial growth factor (VEGF) gene therapy in patients with severe chronic occlusive coronary artery disease.

In recent clinical trials, vascular endothelial growth factor (VEGF) delivered as plasmid DNA percutaneously by a catheter-based, intramyocardial approach, have been demonstrated to be safe and to be associated with a reduction in angina and an increase in exercise time or an improvement in regional wall motion in "no-option patients" with chronic myocardial ischemia.

It has been demonstrated, that BM-derived stem cells mobilized by cytokines as granulocyte colony stimulating factor (G-CSF) were capable of regenerating the myocardial tissue, leading to improve the survival and cardiac function after myocardial infarction.

These data suggested that a combination therapy with exogenous administration of gene vascular growth factor combined with G-CSF mobilization of bone marrow stem cells might induce both angiogenesis and vasculogenesis in ischemic myocardium

Eligibility Criteria:
Inclusion Criteria:

* Reversible ischemia at an adenosine stress single photon emission computerized tomography (SPECT)
* A coronary arteriography demonstrating at least one main coronary vessel from which new collaterals/vessels could be supplied
* Age above 18 years
* Canadian Cardiovascular Society angina classification (CCS) \> 3.

Exclusion Criteria:

* Ejection fraction \<0.40
* Unstable angina pectoris
* Acute myocardial infarction within the last three months
* Diabetes mellitus with proliferative retinopathy
* Diagnosed or suspected cancer disease
* Chronic inflammatory disease
* Premenopausal women
Comparison of Sepsis Prediction Algorithms

Sepsis is a severe response to infection resulting in organ dysfunction and often leading to death. More than 1.5 million people get sepsis every year in the U.S., and 270,000 Americans die from sepsis annually. Delays in the diagnosis of sepsis lead to increased mortality. Several clinical decision support algorithms exist for the early identification of sepsis. The research team will compare the performance of three sepsis prediction algorithms to identify the algorithm that is most accurate and clinically actionable. The algorithms will run in the background of the electronic health record (EHR) and the predictions will not be revealed to patients or clinical staff. In this current evaluation study, the algorithms will not affect any part of a patient's care. The algorithms will be deployed across the Emory healthcare system on data from all patients presenting to the emergency department.

The primary goal of this study is to prospectively evaluate three sepsis prediction algorithms that are embedded in the EHR. The models will be deployed in a "shadow" mode, and the results will not be displayed to the treatment team during this study. Two of the algorithms are proprietary algorithms of the EHR provider (Epic). The third algorithm is an internally developed, open-source algorithm.

The algorithms will compute the probability of sepsis at periodic intervals and will continue to run on a patient's data until the patient's discharge, death, or upon initiation of intravenous antibiotics (at which point there is an indirect record of clinical suspicion of an infection).

Eligibility Criteria:
Inclusion Criteria:

* All adult patients admitted through the ED

Exclusion Criteria:

* None
The Use of Aeriseal ® in the Management of Collateral Ventilation Positive COPD Patients Undergoing ELVR Utilizing Endobronchial Valves.

The aim of this study is to determine the feasibility of combining a lung sealant with endobronchial valves EBV in managing patients with COPD who are collateral ventilation (CV) positive. This study has two arms; arm 1 is for CV positive participants who will receive the lung sealant and EBV; arm 2 is the CV negative group who will only receive EBV as the standard management.


Eligibility Criteria:
Inclusion Criteria:

* i. 18-85 years of age
* ii. Forced Expiratory Volume in 1second (FEV1) 20 - 50%
* iii. Residual Volume (RV) \> 175%
* iv. 6 min walk test \> 150 m
* v. Completed a course of Pulmonary rehabilitation
* vi. STRATX assessment - Left Upper Lobe as the most appropriate lobe to target for ELVR
* vii. This study will be investigating heterogenous emphysema only. Minimum of 15% differential in emphysema destruction scores at -950 HU

Exclusion Criteria:

* i. Acute uncontrolled medical illness including ischemic heart disease, cardiac failure, acute renal impairment
* ii. Acute respiratory tract infections
* iii. Significant bronchiectasis,
* iv. Co-existing interstitial lung diseases, pneumothorax,
* v. Known active malignancy
* vi. Pregnancy.
Role of QRX-3 in Chronic Kidney Disease Patients in Outpatients Clinics

QRX-3, a new drug that stabilized the kidney renal tubular cell and increase the activity of NAD within the kidney cells, is expected to improve baseline renal function when given over a period of one year . The result of the change in renal function will be compared to control without the medication during that same period .


Eligibility Criteria:
Inclusion Criteria:

* Patient with Chronic kidney disease stage 3-5
* Estimated Glomerular function by MDRD of less than 60mls/min
* Patients with declining renal function ( as measured by eGFR by MDRD )
* Rate of decline of eGFR over the last one year of less than 20%
* Negative Serology markers for CKD etiology
* Provider perceived adherence to study follow- up

Exclusion Criteria:

* Rapid rate of decline in kidney function of \> 10 % over 3 months
* Symptomatic renal failure
* Presence of any suspected Acute renal failure superimposed
* Presence of cast , hematuria, or abnormal urinalysis outside of simple UTI
* No known reversible cause of renal decline