cyrilzakka/clinical-trials huggingface dataset:
Trial of Artificial Intelligence for Chest Radiography

Randomized Clinical Trial of the impact of Chest radiograph AI-assisted triage and report generation upon clinical outcomes and an economic analysis of impact of AI decision support on radiology service delivery.

Randomized, prospective selection of patients. Control group involves radiologists reporting chest radiographs as per reference standard clinical workflow Intervention group involves radiologists assisted with AI reporting an AI-triaged worklist of chest radiographs using an AI report generation tool Clinical outcomes on patients are studied at pre-determined study endpoints, including time to discharge from the hospital and re-admission rates.

Economic analysis on cost-avoidance from man-hours saved from report generation and triage.

Eligibility Criteria:
Inclusion Criteria:

* All patients attending radiography to have chest radiographs during the study period

Exclusion Criteria:

* age below 14
* deceased before discharge
* chest radiograph performed in non-standard projections
Comparison of the Non-invasive Biobeat Device With an Invasive Arterial Line

In this clinical study the investigators will compare blood pressure measurements obtained using the non-invasive, continuous and wireless Biobeat monitoring device (a wrist watch or a patch configuration) to an invasive arterial line (radial or femoral) in 30 patients immediately after cardiac surgery, at the intensive care unit.

The Biobeat non-invasive, continuous and wireless monitoring device is based on photoplethysmograph technology. It measures several vital signs, including blood pressure, stroke volume, pulse rate, pulse pressure, heart rate variability, respiratory rate, saturation, cardiac output, cardiac index, and more. The data is transmitted to Biobeat's application (in both Apple and Google Play), and is available on the individual's cellular phone, tablet, or as a full monitoring system in a hospital department. The aim of this study is to compare the Biobeat monitor with the invasive method of blood pressure measurement, an arterial line. The study population includes 30 patients undergoing cardiac surgery. As per local protocol, each one of the participants will come out from the operating room with an arterial line. Once in the intensive care unit, the investigators will attach the Biobeat non-invasive monitor (either wrist watch or a patch, these two configurations are identical in terms of the monitoring system), and monitor the participants for 4 hours. Though both methods are continuous, the investigators will record the vital signs every 15 minutes during the 4 hours of the study.

Eligibility Criteria:
Inclusion Criteria:

* Patients arriving immediately after cardiac surgery to the intensive care unit with an arterial line.

Exclusion Criteria:

* Refusal to participate
* Patients with no arterial line
* Pregnant women
* Individuals under the age of 18 years
* Patients with lack of judgment/mental illness
* Patients working in the Baruch Padeh Medical Center
A Bedside Portable Endoscopy for the Esophageal Foreign Body

The purpose of this study is to determine whether a bedside portable endoscopy is effective in identifying the esophageal foreign body in the emergency room.


Eligibility Criteria:
Inclusion Criteria:

* Patients who visit the emergency room due to apparent foreign body in esophagus

Exclusion Criteria:

* Patients unable to insert a portable endoscopy through the nasal cavity
* Patients unable to undergo conventional esophagogastroduodenoscopy for a gold standard examination
Pilot Study to Evaluate the Knowledge and Understanding on Surgery for Patients With Hysterectomy

The purpose of this study is to assess the level of knowledge of surgery for women who underwent hysterectomy


Eligibility Criteria:
Inclusion Criteria:

* Women who underwent hysterectomy at National Cancer Center, Korea
* Age \> 20 years

Exclusion Criteria:

* The patients who refuse to participate or give consent to the procedure
Breathing Control in Patients With Chronic Obstructive Pulmonary Disease (COPD)

There is a demand for explorative and comparative studies on various non-pharmaceutical efforts in treating and helping chronic obstructive pulmonary disease patients. This study has been developed in light of this need. The main purpose of the project is to test whether a device guided breathing control system can decreasing the feeling of breathlessness in patients with moderate stage and severe stage of COPD. In addition the study could shed light on whether a reduced feeling of breathlessness can lead to improved physical function, and less experience of other symptoms (I.e., depression, anxiety, sleeping difficulties, fatigue, pain) and provide a better quality of life for patients with COPD.


Eligibility Criteria:
Inclusion Criteria:

* Dyspnoea symptoms in daily life
* Spirometry values showing a COPD moderate stage II (FEV1/FVC\<70%, FEV1\<80%) and severity grade at a severe stage III (FEV1/FVC\<70%, FEV1\<50% and FEV1 = 30% of a predicted)
* Be able to read, write and speak Norwegian
* Be at a stable phase of the disease

Exclusion Criteria:

* Changes in pulmonary medication during the last 4 weeks
* Diagnosis of cancer
* Presently attending a pulmonary rehabilitation course or other similar COPD education courses (due to the fact that these courses often have instructions on breathing control), or having attended similar courses during the last six months
* Ongoing exacerbation
* Attending other competitive studies
* Diagnosis of neuromuscular disease
* Diagnosis of dementia
* Attending help from a pulmonary physiotherapist
Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

This study evaluates the addition melatonin and metformin to toremifene in the treatment of locally advanced breast cancer. Third of patients will receive toremifene, other third will receive combination of melatonin and toremifene and other patients will receive combination of metformin and toremifene.

The management of locally advanced breast cancer is complicated issue. Neoadjuvant treatment is often needed to downstage locally advanced ER positive BC tumors prior to surgery. However, many patients do not achieved objective response on treatment. The ability of melatonin and metformin to decrease side effects of chemotherapy had been investigated, moreover, several studies confirm, that this drugs in combination with conventional anti - estrogen treatment may increase objective response. But, this data is still controversial. We hypothesizes that the combinations of melatonin and metformin with conventional anti - estrogen such as toremifene could be more effective than toremifene alone in terms of response rate.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18.
* Obtained Inform Concent.
* Morphologically confirmed breast cancer stage IIB, IIIA, IIIB, IIIC ER positive.
* Eastern Collaborative Oncology Group Performance Status Scale 0-2.
* Expected survival \> 6 month.
* Adequate liver and bone marrow function.

Exclusion Criteria:

* Systemic treatment for breast cancer.
* Stage IV disease.
* Evidence of liver and bone marrow clinically meaningful disfunction.
* Severe uncontrolled concomitant conditions and diseases.
* Pregnancy or lactation.
* Second malignancy.
* Diabetes mellitus requiring drug therapy.
* Any condition preventing study participation by investigators opinion.
Workplace Physical Activity Intervention

In this study, it investigates the effectiveness of workplace physical activity intervention for staff in a 100-bed hospital in Taipei City, Taiwan. The physical activity program takes group coaching and includes aerobic exercise, muscle strength and stretching in combination with nutrition education. The duration of the program is three months (8 sessions per month). The subjects of the study were recruited from full-time employees working at the hospital who attend the program. The recruited employees can take part in the program freely and chose types of activity by themselves. This study measures body mass index, muscle strength, body fat percentage, muscle strength, body mass index, daily energy expenditure, and exercise self-efficacy as the baseline. After 3-month program, we will evaluate the effectiveness of the program. The result is anticipated the greater frequent attendance, the more obvious effectiveness in outcomes.

A three-month group coaching physical activity program in combination with nutrition education was developed for full-time employees working on a 100-bed hospital in Taipei City, Taiwan. Due to the setting that employees can take part in the program freely and chose types of activity by themselves. So participants may have various intensity of participation. This study aims to evaluate the effectiveness of pre- and post- 3-month workplace physical activity programs in body fat percentage, Muscle strength, body mass index, daily energy expenditure, and exercise self-efficacy. One group pretest-posttest design was used for the study by convenience sampling technique. Subjects were recruited from participants of the program. The intervention consists of : (1)education on nutrition: 2 times per month for 3 months, 1 hour/time ; and (2)physical activity: a three-month group coaching program (24 sessions), including three types of exercise courses such as aerobic exercise, muscle strength and stretching. All analyses were performed using Statistics Analysis System version 9.3 and the effects of the intervention were assessed by the paired t-test. Multiple regression analysis was used to determine the contribution of attendances of activities and behavior change stage to effectiveness of workplace physical activity. The level of significance was set at p \< 0.05.

Eligibility Criteria:
Inclusion Criteria:

* full-time employees
* Complete the informed consent

Exclusion Criteria:

* With pacemaker
* accepted or are participating participate other weight control related research or interventional medicine
Thorough QT (TQT) Study of TD-4208 in Healthy Subjects

The purpose of this study is to evaluate if TD-4208, an investigational drug being developed to treat people with chronic obstructive pulmonary disease (COPD), has any effect on the electrical activity of the heart.


Eligibility Criteria:
Inclusion Criteria:

* Subject has a body mass index (BMI) of 19 to 32 kg/m2, inclusive, and weight of at least 55 kg.
* Subject is able to communicate well with the investigator and to comply with the study procedures, requirements, and restrictions.

Exclusion Criteria:

* Subject has a prior history of myocardial infarction, acute coronary syndrome, cerebrovascular accident, transient ischemic attack, ventricular tachycardia, atrial fibrillation, personal or known family history of congenital long QT syndrome or known family history of sudden death with unknown cause, a pacemaker or implantable cardioverter defibrillator, cardiac or cerebral stent placement or angioplasty, or clinically significant valvular heart disease.
* Subject has evidence or history of clinically significant allergic (except for untreated, asymptomatic, seasonal allergies at time of dosing), hematologic, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, or neurological disease.
Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.


Eligibility Criteria:
Inclusion Criteria:

* 18-65 years;
* Elective endoscopic transsphenoidal resection of pituitary adenomas;
* ASA status I-III;
* Informed consent signed by patients.

Exclusion Criteria:

* emergency surgery;
* complicated with cerebrovascular disease;
* complicated with pulmonary disease, oxygen saturation below 95% without oxygen;
* expected to retain endotracheal intubation;
* preoperative disturbance of consciousness was not compatible with assessment;
* complicated with primary hypothyroidism;
* previous history of cervical surgery, burns, and radiotherapy;
* BMI \>30kg/m2;
* invasive pituitary adenoma with Knosp grade 4.
Immune Response Study of Influenza Vaccine

An observational clinical study will be performed in subjects aged 12-60 years old to describe the dynamic changes of humoral immune/cellular immunity after vaccination of influenza vaccine, and to discuss the role of different antibodies against influenza virus infection, and to look for possible factors related to side effects with the vaccine.

A randomized clinical trial will be conducted to describe immune response of seasonal influenza virus vaccine in a single center in China. 200 subjects aged 18-60 years will be enrolled under the premise of informed consent and receive one dose of vaccine. All vaccinations will be done by specific study personnel, who do not take part in the assessment of safety or immunogenicity. Adverse events will be recorded after vaccination and blood samples were collected at 0,7,14,28 days for antibody detection and split vaccine neutralizing antibody detection, determination of cellular immune function in the same time.

The clinical program approved by the ethics committee will be performed by the researchers independently. Inspectors designated by the sponsor will take meticulous on-site audits to ensure the safety specifications during the whole process of research.

Eligibility Criteria:
Inclusion Criteria:

* aged 12-60 years old
* male or non-pregnant female
* volunteers
* clinically healthy as determined by: medical history inquiring and physical examination
* provide written informed consents before joining the trial

Exclusion Criteria:

* infected with Influenza A virus subtype H1N1(2009),
* vaccinated with seasonal influenza vaccine,
* allergic to any ingredient of vaccine,
* autoimmune disease or immunodeficiency,
* active malignancy,
* bleeding disorder,
* seizure disorder,
* Guillain-Barre Syndrome,
* treatment with cytotoxic or immunosuppressive drugs within the past 6 months,
* receipt of blood products within the past 3 months,
* administration of any other investigational research agents or live attenuated vaccine within 30 days,
* administration of subunit or inactivated vaccines within 14 days,
* axillary temperature over 37.0℃ at the time of vaccination.
Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings

This study is being done to find out if a smartphone app can identify absence seizures. Children who have a history of absence seizures, as well as children without any seizure history, will be testing out the app. If participating the child will be guided through hyperventilation, an activity that asks the child to take quick, deep breaths. The app will record video of the child's face and sounds they make during hyperventilation. Hyperventilation is a safe and established technique frequently used during EEG (electroencephalogram) to encourage seizure occurrence. The App will be used during a regularly scheduled EEG.

This observational study focuses on validating the use of the Eysz mHealth App - a smartphone-based tool for guided Hyperventilation (HV) and data collection - to aid clinicians in identifying absence seizures in people at risk for childhood absence epilepsy (CAE). The Eysz mHealth app will guide users through HV via interactive graphics while capturing audio and video data using smartphone sensors (e.g., camera, microphone) from which eye movements, facial biometrics/ expressions, number and length of exhales will be extracted.

The goal of this observational study is to determine an epileptologist's performance in identifying HV-induced absence seizures using video data collected from a smartphone when compared to the gold standard interpretation of the EEG. The exploratory goal is to develop machine learning based algorithms to identify HV-induced seizures.

Eligibility Criteria:
Inclusion Criteria:

* typical absence seizure during use of the Eysz Hyperventilation Recorder or Control

Exclusion Criteria:

* Other seizure type besides typical absence seizure during use of the Eysz Hyperventilation Recorder
* subclinical seizure activity
* inability to participate with study procedures
* contraindications to hyperventilation including history of subarachnoid hemorrhage, sickle cell anemia, recent cerebrovascular accident or myocardial infarction, significant cardiopulmonary disease, active asthma, known aneurysm, known moyamoya disease, or pregnancy.
* People who have a history of generalized tonic clonic convulsions (GTCs) provoked by hyperventilation
Adaptation in Polyphenol Bioavailability and Bioactivity During Long Term Exposure to Polyphenol-Rich Foods

There are two primary objectives to be addressed in this study: to assess the differential response in bioavailability and metabolic pathways between lean and obese individuals exposed to acute, short term (14 day), and long-term (10-week) consumption of polyphenol-rich fruits (berries and apple), and beverages (tea); and to determine the differential systemic and gut anti-inflammatory response between obese and lean individuals exposed to polyphenol-rich fruits (berries and apple), and beverages (tea).


Eligibility Criteria:
Exclusion Criteria:

* Younger than 25 years old or older than 75 years old
* Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol (dicumarol), or Miradon (anisindione)
* Presence of any gastrointestinal disease, metabolic disease, bariatric surgery, or malabsorption syndromes that may interfere with the study goals
* Have been pregnant during the previous 12 months, are currently pregnant or lactating, or plan to become pregnant during the study
* Type 2 diabetes requiring the use of oral antidiabetic agents or insulin
* Fasting triglycerides greater than 300 mg/dL
* Fasting glucose greater than 126 mg/dL
* History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
* Use of prescription or over-the-counter antiobesity medications or supplements (e.g., phenylpropanolamine, ephedrine, caffeine) during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity
* Active cardiovascular disease (such as a heart attack or procedure within the past three months or participation in a cardiac rehabilitation program within the last three months, stroke, or history/treatment for transient ischemic attacks in the past three months, or documented history of pulmonary embolus in the past six months).
* Use of any tobacco products in past 3 months
* Unwillingness to abstain from herbal supplements for two weeks prior to the study and during the study
* Known (self-reported) allergy or adverse reaction to study foods
* Unable or unwilling to give informed consent or communicate with study staff
* Self-report of alcohol or substance abuse within the past twelve months and/or current acute treatment or rehabilitation program for these problems (Long-term participation in Alcoholics Anonymous is not an exclusion)
The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF

This study is trying to find out how best to improve common measures of health and survival in those diagnosed with heart failure with preserved ejection fraction (HFpEF) through the implementation of 4 weeks of an exercise training program consisting of high intensity interval training, dietary approaches to stop hypertension (DASH diet), or a combination of the two. Currently there are not established guidelines that have been shown to improve clinical end points in those with this HFpEF.

In the face of a rapidly growing population of older, HFpEF patients, there remains a need to identify ideal rehabilitative therapies to enhance improvements in the physical function of these patients. Pharmacological trials in this population have been characterized by a failure to significantly improve exercise tolerance and hard clinical outcomes and this is likely due to their singular cardiovascular focus. Exercise appears to be a promising intervention to improve cardiorespiratory fitness and reduce cardiovascular risk. Further, evidence-based dietary guidelines for patients with heart failure are lacking. Although a high-protein, low-carbohydrate diet is associated with improvements in traditional CV risk markers in patients with heart failure, it may raise cardiovascular risk in this population by adversely affecting endothelial function, increasing susceptibility to myocardial ischemia, and by inducing a pro-inflammatory state due to increased bacterial and LPS translocation through the ischemic gut. Thus, the investigators will explore the effects of the high-carbohydrate, high-fiber DASH diet due to its potential to have salutary effects on vascular risk in this population. In this study, the investigators will examine the singular and combined effects of exercise and a DASH diet in patients with HFpEF on markers of cardiovascular risk.

Eligibility Criteria:
Inclusion Criteria:

* ≥40 years of age
* Diagnosed with heart failure with preserved ejection fraction
* NYHA class II-III symptoms
* Physician clearance to undergo exercise training
* Physician clearance to consume DASH diet
* Complete COVID-19 vaccination status

Exclusion Criteria:

* Unstable angina
* Myocardial infarction in the past 4 weeks
* Uncompensated heart failure
* NYHA class IV symptoms
* Complex ventricular arrhythmias
* Musculoskeletal contraindications to stationary bicycling exercise
* Symptomatic severe aortic stenosis
* Acute pulmonary embolus
* Acute myocarditis
* Uncontrolled hypertension
* Medication non-compliance
* Unable to follow DASH diet
* Food allergies (Nuts, wheat)
* Pregnant women