cyrilzakka/clinical-trials huggingface dataset:
Load During Sweep Rowing and the Influence on the Posture

The aim is to assess the influence of asymmetric training on the locomotor system in sweep rowers. To analyse possible changes objectively, the axial position of the hull will be assessed using Moiré topography, and the symmetry of foot loading will be monitored with a pedobarograph. Furthermore, the Visual Analog scale and Cluster of Laslett will determine whether an asymmetric load can provoke pain in the lumbar region or cause a blockage in the SI joint. In the experimental study, there will be three different groups of participants. Selected sweep rowers will make the first study group. The second group will consist of scull rowers, and the last control group will consist of people with no experience with rowing. The selected participants will undergo the first measurement at the turn of the spring and summer seasons when intensive preparation for rowing competitions begins, in which sweep rowers train mainly on water and asymmetrically. The measurement results in the three groups will be further compared with each other to evaluate whether statistically significant differences can be found.

Methods: 21 sweep rowers, 20 scull rowers and 23 non-rowing peers were enrolled on the study of this diploma thesis. Each subject was assessed using DIERS formetic 4D and DIERS pedoscan devices. Additionally, participants in each group were assessed by FAIR test, Cluster of Laslett, trigger point palpation of the m. piriformis and Visual analogue scale were used to assess pain intensity in the lumbar region.

Eligibility Criteria:
Inclusion Criteria for rowers:

* Training and racing exclusively in the unpaired disciplines of competitive rowing in the Czech Republic for a group of unpaired rowers
* Training and racing exclusively in the pairs disciplines of competitive rowing in the Czech Republic for the group of pairs rowers
* Dedication to rowing for more than three years
* Frequency of training at least three times a week or more

Inclusion Criteria for non-rowers:

-Engaging in sports recreationally without higher intensity training (less than three times a week) or at all.

Exclusion Criteria for rowers:

* The presence of lumbar spine pain at a time when the athlete was not yet exercising
* Presence of musculoskeletal pain caused by a condition for which the athlete is actively being treated (Morbus Bechterev, spondylodiscitis, etc.)
* Presence of a previously diagnosed internal, orthopaedic or neurological disease
* Lateral spinal misalignment caused by a previously diagnosed disease (congenital scoliosis, idiopathic scoliosis, Morbus Scheuermann, etc.)

Exclusion Criteria for non-rowers:

* Active participation in sports associated with an asymmetric load, such as tennis, floorball, hockey and others (training once a week or more)
* Presence of pain caused by a disease for which the person is actively treated (Morbus Bechterev, spondylodiscitis, etc.)
* Presence of a previously diagnosed internal, orthopaedic or neurological disease
* Lateral spinal misalignment caused by a previously diagnosed disease (congenital scoliosis, idiopathic scoliosis, Morbus Scheuermann, etc.)
BD Prevue(TM) II Peripheral Vascular Access System With Cue(TM) Needle Tracking Technology Clinical Study

This post-market study is being conducted to generate safety and performance data on the BD Prevue(TM) II Peripheral Vascular Access System with Cue(TM) Needle Tracking Technology. The data will be utilized to support regional registrations (for example, EU MDR), and document any unforeseen residual risks.

This is an observational post-market, human subject study to evaluate the safety and performance of the BD Prevue(TM) II Peripheral Vascular Access System with Cue(TM) Needle Tracking Technology. Subjects will be recruited for participation based on need for IV catheter (midline catheters included) placement in a hospital setting.

Enrolled subjects will go through ultrasound-guided peripheral intravenous catheter (USGPIV) placement as part of their clinical care. USGPIV is defined as a procedure in which an ultrasound machine is used to assist a qualified health care provider with IV cannulation from skin puncture through venipuncture via direct visualization on the ultrasound machine in real time.

Eligibility Criteria:
Inclusion Criteria:

* Age 1 years, or older
* A patient who is a candidate for an ultrasound-guided peripheral intravenous catheter (midline catheters included) placement procedure using BD PrevueTM II Peripheral Vascular Access System with CueTM Needle Tracking Technology as assessed per their clinician(s)
* Able and willing to provide informed consent or legal authorized representative (LAR) authorized to give consent on behalf of the subject

Exclusion Criteria:

* Any patient in whom ultrasound procedure might interfere with medical care or create undue hardship
* Known, or suspected, allergy to materials contained in the BD PrevueTM II Peripheral Vascular Access System with CueTM Needle Tracking Technology or accessories that may come in contact with the patient
* Localized skin, tissue, or other clinical factors that would prevent completion of the ultrasound procedure
* Previous medical history that would prevent completion of the ultrasound procedure
Emotional Security and Quality of Life Among Breast Cancer Patient Who Have Undergo Mastectomy

Breast cancer is the most common cause of cancer death among women worldwide. Incidence rates are high in more developed countries than rates in less developed countries In Egypt, standardized age of cancers are 166.6per 100.000 in both sexes cancer breast represent 32%in females and 15.4%in both sexes of all cancer Mastectomy is an important treatment method in Brest cancer. But, mastectomy has a deep and stable negative impact on a woman because, mastectomy as a treatment option, can result in a sense of mutilation and diminished self-worth and may threaten perceptions of femininity Body image of a woman includes the symbolic meaning and importance of her breasts. The more she values her breasts, more devastating effects of having a mastectomy can be. it has been reported that cutting off/amputating one or both breasts was associated with several problems in women such as loss of fertility, charm and sexuality, fear of recurrence Social support plays an important role in reducing the pressure and improving health. Cancer patients who lack social support may be more pessimistic and desperate as they are constantly looking for support from others Therefore, it is critical for health care professionals to become familiar with the impact of a breast cancer diagnosis and its treatment on patient's quality of life .

Breast cancer is the most common cause of cancer death among women worldwide. Incidence rates are high in more developed countries than rates in less developed countries In Egypt, standardized age of cancers are 166.6per 100.000 in both sexes cancer breast represent 32%in females and 15.4%in both sexes of all cancer Mastectomy is an important treatment method in Brest cancer. But, mastectomy has a deep and stable negative impact on a woman because, mastectomy as a treatment option, can result in a sense of mutilation and diminished self-worth and may threaten perceptions of femininity Body image of a woman includes the symbolic meaning and importance of her breasts. The more she values her breasts, more devastating effects of having a mastectomy can be. it has been reported that cutting off/amputating one or both breasts was associated with several problems in women such as loss of fertility, charm and sexuality, fear of recurrence Social support plays an important role in reducing the pressure and improving health. Cancer patients who lack social support may be more pessimistic and desperate as they are constantly looking for support from others Therefore, it is critical for health care professionals to become familiar with the impact of a breast cancer diagnosis and its treatment on patient's quality of life

Eligibility Criteria:
Inclusion Criteria:

1. female patient between 18y and 55y
2. a first-time breast cancer diagnosis
3. post-operative mastectomized patients
4. clear consent to participate in study

Exclusion Criteria:

1. male gender
2. females patient with concurrent comorbid psychiatric or neurological disorders
3. age younger than 18y
4. patients with disease recurrence, patients presenting with other malignancies
A Functional Pain Scale to Improve the Patient Experience

This will be an observational cohort study to evaluate pain measurement after surgery using a new functional pain scale.

Patients admitted for orthopedic surgery may take part in this research. Participants will be assessed using three different pain scales: numeric rating scale (NRS), FACES pain scale and a new functional pain scale (FPS).

Eligibility Criteria:
Inclusion Criteria:

* Completed orthopedic (hip or knee) surgery
* English as primary language and able to read
* Low risk as assessed by Opioid Risk Assessment Tool (ORAT)
* No history of opioid abuse
* Patients with a diagnosis of chronic pain other than the scheduled hip or knee meeting the above criteria may be included.

Exclusion Criteria:

* Previous diagnosis of cognitive impairment
Feasibility of Auricular Acupressure as an Adjunct Treatment for Neonatal Abstinence Syndrome (NAS)

This study will assess the feasibility of implementing auricular acupressure as an additional non-pharmacologic therapy for neonates at risk for developing neonatal abstinence syndrome (NAS) at Monroe Carrell Jr Children's Hospital at Vanderbilt University Medical Center (VUMC).

NAS is a condition in which newborns experience withdrawal symptoms as a result of in utero exposure to opioids and/or other substances ingested by the mother. The condition has significantly risen over the past 20 years. First line treatments for NAS involve the maximization of non-pharmacologic therapies. NAS management focuses on reducing or eliminating the need for medication management to prevent further developmental complications, promote maternal bonding, and reduce hospital length of stay.

Auricular acupuncture has been used for the treatment of addiction and has demonstrated efficacy in the adult population. Current evidence suggests that acupuncture is safe and beneficial for multiple conditions that impact neonatal and pediatric populations including NAS. Acupressure is a less invasive therapy and may serve as an additional non-pharmacological adjunct to ease the severe discomfort of withdrawal in neonates at risk for NAS.

This study will assess the feasibility of implementing auricular acupressure as an additional non-pharmacologic therapy for neonates at risk for developing neonatal abstinence syndrome (NAS) at Monroe Carrell Jr Children's Hospital at Vanderbilt University Medical Center (VUMC).

Eligibility Criteria:
Inclusion Criteria:

* 37 weeks gestational age or greater
* Maternal age 16 or older
* Substance exposure in utero including opioids, illicit drugs, or other medications that cause neonatal withdrawal

Exclusion Criteria:

* Birth trauma
* Neonatal asphyxia
* Maternal or neonatal infection
* Congenital abnormalities
* Requiring Neonatal Intensive Care Unit (NICU) care
Improving Chronic Illness Management With the Apsaalooke Nation: The Baa Nnilah Project

This is a group randomized trial of an intervention to improve chronic illness self-management.


Eligibility Criteria:
Inclusion Criteria:

* ≥ 25 years
* AI
* diagnosed with diabetes
* hypertension
* osteoporosis
* liver disease
* chronic lung disease (asthma, chronic bronchitis or emphysema)
* heart disease (coronary artery disease or congestive heart failure)
* stroke (completed cerebrovascular accident with neurologic handicap and normal mentation)
* chronic arthritis

Exclusion Criteria:

* major medical illness that precludes their attendance at 7 meetings
* \<25 years of age
Effect of Vitamin D Supplementation on Vedolizumab Response in Patients With Ulcerative Colitis

It is uncertain whether vitD3 supplementation is beneficial for the remission of ulcerative colitis (UC). The effects of vitD3 supplements on the efficacy of vidrecizumab in Chinese UC patients were retrospectively analyzed. Methods: Patients with moderate to severe UC were recorded. These patients were initially treated with VDZ. VitD3 supplementation was defined as 400IU/d vitD3 supplementation during the first infusion of VDZ and continued throughout the follow-up period. Disease activity was assessed using the modified Mayo score.


Eligibility Criteria:
Inclusion Criteria:

* moderate-to-severe UC
* Treated with Vedolizumab

Exclusion Criteria:

* had recent supplementation of vitD3
* pregnant
* had cognitive/developmental disorders that affected their ability to complete the study procedures
* had medical illness or therapies potentially affecting bone, nutrition or growth status
* unknown or untested baseline serum 25(OH)D level
The Long-term Outcome After Toric Intraocular Lens Implantation

Corneal astigmatism is refractive error that impairs uncorrected visual acuity. When patients undergo cataract surgery, implantation of toric IOL is deemed the most effective choice for correcting corneal astigmatism and reducing postoperative spectacle dependence. Previous studies report that the visual effects and rotational stability of toric IOLs are well maintained over 1- or 2-year follow-up periods. However, the long-term changes in the effects of toric IOLs remain unclear.

Corneal astigmatism is refractive error that impairs uncorrected visual acuity. When patients undergo cataract surgery, implantation of toric IOL is deemed the most effective choice for correcting corneal astigmatism and reducing postoperative spectacle dependence. Previous studies report that the visual effects and rotational stability of toric IOLs are well maintained over 1- or 2-year follow-up periods. However, there is a long-term against-the-rule (ATR) change of corneal astigmatism with aging，which influences the long-term outcomes of refractive surgery. The long-term changes in the effects of toric IOLs remain unclear. This study aim to observe the clinical effect of Toric IOL implantation in the correction of corneal astigmatism.

Eligibility Criteria:
Inclusion Criteria:

* ≥18years old
* Regular astigmatism
* Corneal astigmatism ≥ 0.75D

Exclusion Criteria:

* Macular degeneration and retinal disease, history of glaucoma, corneal disease
* Previous corneal or intraocular surgery, and history of ocular inflammation.
* Pupils can not be dilated (\< 7mm)
Oncoxin® and Quality of Life in Cancer Patients

It is expected that additional support with certain micronutrients may improve prognosis, decrease the frequency of side effects and complications and maintain high relative dose intensity of anticancer treatments. Food supplement ONCOXIN (ONCX) contains amino acids, vitamins, minerals and biologically active substances of natural origin with high immunostimulatory and antioxidant activity. Present study is a real world experience study intended to evaluate the efficacy of ONCX in cancer patients.

The study was conducted at 9 centers across the Russia and Kazakhstan. Patients were allocated in 2:1 comparison groups for the ONCX and control groups, respectively. A total of 133 patients were enrolled in the study; 84 in the ONCX group and 49 as controls.

ONCX contains microelements, vitamins, amino acids and certain naturally occurring, biologically active substances.

It is expected that additional support with certain micronutrients may improve prognosis, decrease the frequency of side effects and complications and maintain the Quality of life in cancer patients.

Eligibility Criteria:
Inclusion Criteria:

1. Male and female patients who had signed an informed consent.
2. Males and females aged 50-70 y/o
3. Gastric cancer IIB-IIIC, Non-small cell lung cancer IIB-IIIA
4. R0 surgery
5. Adjuvant chemotherapy (ACT) required, 2nd and further course of ACT, XELOX regimen of ACT for gastric cancer and paclitaxel+carboplatin regimen for non-small cell lung cancer.
6. Body mass index (BMI) ≥ 15, serum albumin ≥ 25 g/l.
7. Eastern Cooperative Oncology Group performance status ≤ 2

Exclusion Criteria:

1. Severe concomitant diseases or conditions that may complicate or make impossible the patient's participation in the study, or make it difficult to interpret the clinical data (including mental disorders, severe infectious and parasitic diseases and intolerability to any of the ONCX components).
2. The patient's family or official relations with a member of staff of the study center.
3. The patient's failure to assess his/her physical and/or emotional condition.
4. The patient's failure to comply with the study requirements.
5. The patient's refusal to participate in the study and pregnancy or lactation.
Study of the Efficacy and Safety of Longidaze® for the Treatment of Patients With External Genital Endometriosis

A study is being conducted to evaluate the efficacy and safety of Longidaze for the prevention and treatment of external genital endometriosis .

The aim of the study is to compare the outcomes of complex therapy in patients with external genital endometriosis who, in addition to hormonal therapy, were prescribed Longidaze®, vaginal and rectal suppositories, 3000 IU, with the outcomes of therapy in patients who received only hormonal therapy.

Eligibility Criteria:
Inclusion Criteria:

1. Documented informed consent;
2. Patients over 18 years of age with active menstrual function;
3. Women with external genital endometriosis, confirmed morphologically and visually during laparoscopic or laparotomy surgery performed 10 years to 2 weeks prior to Day 0;
4. Patients in the framework of routine clinical practice in accordance with the instructions for use, prior to inclusion in the study, are assigned one of the following therapy regimens:

   * monotherapy with dienogest 2 mg daily for at least 6 months per os
   * complex treatment with dienogest 2 mg daily for at least 6 months per os in combination with vaginal and rectal suppositories Longidaze® 1 suppository 1 time every 2 days 10 suppositories, and then 1 suppository 1 time in 7 days 17 suppositories for another 120 days;
5. Willingness to use barrier methods of contraception.

Exclusion Criteria:

1. Women before menarche or after menopause
2. Adenomyosis;
3. Amenorrhea (more than 3 months in a row within 6 months before screening);
4. Patients who are scheduled to undergo surgery for endometriosis during the study;
5. Hormone therapy for endometriosis or the use of aromatase inhibitors within 16 weeks prior to Day 0;
6. Daily use of pain relievers for 7 consecutive days or more due to any other reason other than endometriosis;

6. Participation in clinical trials less than 30 days before the screening visit and / or 5 drug half-lives, whichever is longer.
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy

Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%. Cerebral blood flow autoregulation (CA) is the ability of the brain to maintain the relative stability of cerebral blood flow, and cerebral oxygen index (COx) can be used to reflect CA. A negative value of cerebral oxygen index or a value near zero indicates that CA is complete, and cerebral oxygen index close to 1 indicates that CA has lost its ability. In theory, real-time monitoring of CA function by cerebral oxygen index and individualized management strategy with this goal can potentially reduce perioperative ischemic brain injury. The purpose of this study is to explore the influence of the management strategy of monitoring CA function based on regional cerebral oxygen saturation on the postoperative neurological complications of CEA patients.


Eligibility Criteria:
Inclusion Criteria:

* Patients scheduled for elective carotid endarterectomy
* ASA Ⅱ or Ⅲ
* aged 18-80 years old

Exclusion Criteria:

* preoperative moderate and severe cognitive impairment
* preoperative psychotropic medication history within one year
* history of neurosurgery
* have speech or language impairments
TRANPAS - TReating Anorexia Nervosa Plus Autism Spectrum

In a pilot study, the investigators will validate a so-called autism care location in an inpatient ward. The care location will be adapted for patients with anorexia nervosa (AN) and concurrent autism (AN+autism). In order to investigate the effect of a tailored care location for patients with AN + autism, the evaluation will include weight development and changes in nutritional intake, eating disorder and anxiety symptoms. The overall aim is to improve treatment for this specific AN subgroup, that otherwise has a worse prognosis regarding AN recovery.

Anorexia nervosa (AN) is a serious eating disorder and has the highest mortality rate of all psychiatric illnesses. Adolescence is the most common age of onset. Nine out of ten people who fall ill are girls/women, and 2% of all girls/women will fall ill with AN at some point in their lives. In AN, one engages in self-starvation, which in turn leads to underweight. 75 - 80% of individuals with AN recover during adolescence, while the remainder are at high risk of developing chronic AN. For the individual, the chronic condition means great suffering in the form of serious psychiatric and somatic co-morbidity, social isolation and reduced/lack of work ability. People with autism show social withdrawal and reduced flexibility, reminiscent of the symptoms seen in AN. An estimated 15 - 20% of all individuals with AN also have autism. People with AN and concurrent autism run an increased risk of a worse prognosis, as they have more difficulty absorbing treatment, which in itself increases the risk of the condition becoming chronic. Today, there is no scientific evidence for how people with AN and concurrent autism should be treated.

In a pilot study, the investigators will validate a so-called autism care location in our inpatient ward, at Sahlgrenska University Hospital in Gothenburg, Sweden. The care location will be adapted for patients with AN and concurrent autism (AN+autism). In order to investigate the effect of a tailored care location for patients with AN + autism, the evaluation will include weight development and changes in nutritional intake, eating disorder and anxiety symptoms. The overall aim is to improve treatment for this specific AN subgroup, that otherwise has a worse prognosis regarding AN recovery.

Eligibility Criteria:
Inclusion Criteria:

* 25 years or older
* Meeting criteria for both anorexia nervosa and autism spectrum disorder according to the DSM-5
* In need of inpatient care due to anorexia nervosa

Exclusion Criteria:

* 24 years or younger
* Not in need of inpatient care due to anorexia nervosa
* Not meeting criteria for both anorexia nervosa and autism spectrum disorder according to the DSM-5