cyrilzakka/clinical-trials huggingface dataset:
Prevalence of Chronic Inebriates to the Emergency Department and Suitability for Sobering House Services

This study is intended to evaluate the prevalence of chronically inebriated patients in the Emergeny Department (ED). Patients will be identified prospectively by screening all patients (24/7) presenting to the ED for one month. A running tally of all patients in the ED will be kept. Of these patients, any patient that is noted to have alcohol intoxication will be identified. The chart of that patient will be reviewed for details about the patient's alcohol use and for the patient's suitability for a sobering house, which is a place where intoxicated patients can go to await sobriety. The chart will also be reviewed for the number of previous visits for alcohol use to our hospital ever and in the last year.

For this cross-sectional study, all patients presenting to the ED of an urban, Level 1 trauma center for one month were prospectively screened by trained research associates. When an intoxicated patient was identified, study information including patient demographics, diagnoses, vital signs, blood alcohol concentration (BAC), GCS on arrival, ability to ambulate independently on arrival, use of physical or chemical restraint, previous ED visits, length of stay, and health insurance was collected. Data was analyzed using descriptive statistics.

Eligibility Criteria:
Inclusion Criteria:

* Patients in the emergency department for alcohol intoxication

Exclusion Criteria:

* Under 18
* Prisoners
* Pregnancy
Transversus Abdominis Plane Block in the Analgesia of Acute Pancreatitis

Background Severe abdominal pain is a hallmark of acute pancreatitis (AP). A control pain is often difficult. Transversus Abdominis Plane (TAP) block has been used in pain control in patients with exacerbation of chronic pancreatitis.

Objectives To evaluate the effect of Bilateral Blockade of the Abdominal Transverse Muscle Plane (TAP Block) in the analgesic control of patients with acute pancreatitis; compared to standard intravenous analgesia.

Methods A randomized controlled trial of parallel groups will be conducted. The Study will have a multicenter development. Study population: Adult patients admitted for episode of AP, with uncontrolled pain (visual analogue scale (VAS) equal to or greater than 5 after the administration of standard analgesia. Randomization Groups: Group A: Patients who will undergo TAP block as analgesic procedure added to standard analgesia. Group B: Patients to whom morphine 2 mg / ev will be administered as analgesic procedure added to standard analgesia.

Timing of pain determination (Visual Analogue Scale, VAS):

* Before conventional analgesia
* Immediately before Randomization
* 15 minutes after the administration of the analgesic treatment object of the study.
* One hour after the procedure.
* Every 8 hours, during the next 4 days or until discharge of the patient.
* Whenever the patient needs a dose of supplemental rescue analgesia. Analysis of data All results will be evaluated according to the initial "intention to treat". There will be a blinded assessment of the results after the last patient in the trial has completed the follow-up. The results will be presented as relative risks with their corresponding confidence intervals. P \<0.05 will be considered statistically significant. In case of imbalance between the two treatment groups, a multivariate logistic regression is used to correct possible confounding factors.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of acute pancreatitis according to modified Atlanta criteria .
* Patients with the ability to understand the VAS scale and express their level of pain.
* Patients over 18 years old.
* Uncontrolled pain, with VAS ≥ 5 after the administration of standard analgesia.
* Material and technical possibility of performing the TAP technique immediately after randomization.
* Informed consent of the participating patients for inclusion in the study.
* Informed consent of the participating patients for the administration of TAP.
* Normality of coagulation levels

Exclusion Criteria:

* Patients with American Society of Anaesthesia (ASA) levels IV and V
* Patients with chronic pancreatitis
* Pregnancy
* Patients with chronic treatment with morphic medication
Feasibility of Brachial Plexus Ultrasound in Evaluation of Patients With Brachial Plexus Injuries

Evaluation of ultrasound as a diagnostic tool in assessment of patients with brachial plexus injuries before undergoing surgical exploration

Ultrasound of the brachial plexus is particularly good for assessing brachial plexus injuries, nerve sheath tumors,perineural fibrosis, metastasis, some inflammatory neuropathies, neuralgic amyotrophy and post traumatic sequele

Eligibility Criteria:
Inclusion Criteria:

* all patients ages with brachial plexus injuries

Exclusion Criteria:

* patients underwent brachial plexus surgery before
* patients with surgical emphysema
* patients with serious skeletal malformations
Electrophysiological Mechanisms and Inhibitory Cardiac Syncope

OBJECTIVES: To evaluate syncope recurrence at follow up in patients with a positive cardio inhibitory response to the head up tilt testing (HUT) evaluation.

METHODS: 36 consecutive patients affected by cardio inhibitory syncope to HUT without asystolia (2A type) have been enrolled in this study. These patients have been studied by electrophysiological study (ES). After ES patients have been differently treated (interventional treatment group A, v/s drug therapy group), and followed up during 360 days, to evaluate syncope recurrences.


Eligibility Criteria:
Inclusion Criteria:

* age more than 18, normal heart function, more than 1 syncope event for year.

Exclusion Criteria:

* age inferior 18 years, history of myocardial infarction, heart failure, structural heart disease.
Gynaecological Care for Transgender People in France in 2024.

To date, the transgender population, still poorly characterized, tends to increase. The impact of gender-affirming hormone therapy (GAHT) in this population remains poorly understood, and few data are published on the gynecological repercussions of such therapy. A recent literature review by a French team suggests gynecological follow-up procedures for transgender people.

The hypothesis of this study is that transgender population in France does not have appropriate gynecological care, and the study would like to find out, directly from the people concerned, the current state of gynecological care for transgender people in France. To do this, ths study plan to send out a questionnaire to transgender people (via healthcare networks and also transgender associations) to ask them about their actual gynecological care and their knowledge of recommended gynecological care.

The aim is to set up a descriptive, declarative study based on a questionnaire created specifically for this work.

This project will use a questionnaire for transwomen people and another one for transmen people. Transgender people will be approached via Trans associations and healthcare networks. An online link to the questionnaire will be sent to trans associations and healthcare networks for distribution to the target population thanks to a flyer.

Eligibility Criteria:
Inclusion Criteria:

* French-speaking transgender person (transgender women or transgender men)
* age ≥18 years

Exclusion Criteria:

* age \<18 years
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website

Tobacco use is still the leading cause of preventable disease and death in the United States. Tobacco quit lines are effective at helping smokers to quit, but quit lines are underutilized, especially by men and racial/ethnic minorities. Guided imagery is effective at helping people quit smoking, and is appealing to males and diverse racial groups, but has limited reach. The proposed study will develop and test the feasibility and acceptability of a guided imagery tobacco cessation intervention that is delivered by a combination of quit line coaches and an interactive website. The investigators hypothesize that guided mental imagery delivered using the quit line "coaching model" combined with an interactive website could be an effective intervention strategy.

The objective of this three year R34 application is to develop and test the feasibility of a theory-driven, telephone plus web-based, guided mental imagery intervention for smoking cessation.

Aim 1. Develop a theory-based, guided mental imagery tobacco cessation intervention for quit line callers with input from expert consultants in health disparities and a Community Advisory Board representing diverse populations and tobacco control stakeholders. The intervention will include phone-based coaching, an interactive website, and optional cessation medication. It will be focus tested with 40 smokers (from diverse racial/ethnic and age groups with at least 40% males), and usability tested with 5 smokers.

Aim 2. Develop training and competency standards for, and train, four coaches in the implementation of the guided imagery and control interventions. Coaches will be assessed at 6-weeks and 6-months post-training for implementation fidelity and satisfaction.

Aim 3. Conduct a feasibility trial (N=100) to gather preliminary data on the effects of the guided mental imagery intervention on quit line callers' tobacco use, cravings, and self-efficacy to quit smoking, and to refine study procedures, including recruitment, retention, and use of intervention components. Participants will be randomly assigned to receive either the Imagery Intervention (N=50) or an attention control condition (N=50) as delivered by study coaches. Participants will be assessed at baseline, 6-weeks and 6-months post-enrollment. Primary outcomes will be self-reported point prevalence and prolonged abstinence of tobacco use. Biochemical validation will be conducted on a sub-sample to determine validity of self-reported abstinence in this population. Secondary outcomes will be self-reported cravings and self-efficacy.

Eligibility Criteria:
Inclusion Criteria:

* Current smoker trying to quit
* Speak English
* Internet access
* Email access
* Live in the state of Arizona, USA

Exclusion Criteria:

* Having enrolled and participated in Quit line services in the past 12 months
* Diagnosed with a serious mental illness (e.g. current depression)
Efficacy and Safety Study of OPC-1085EL Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

The purpose of this study is to determine the efficacy and safety of OPC-1085EL ophthalmic solution in comparison with carteolol long-acting ophthalmic solution in subjects who are insufficiently responsive to carteolol long-acting ophthalmic solution.


Eligibility Criteria:
Inclusion Criteria:

* Subjects with diagnosis of bilateral primary open-angle glaucoma or ocular hypertension

Exclusion Criteria:

* Subjects with ocular conditions as defined by the protocol
The Effect of Emotional Freedom Technique on Breastfeeding Success and Self-Efficacy

This study was planned to determine the effect of emotional freedom technique (EFT) on breastfeeding success and self-efficacy in primiparous women in the early postpartum period who had a cesarean delivery.

Breast milk is an easily digestible, natural food that reduces the morbidity and mortality of the newborn and contains the fluid, energy and nutrients necessary for its physical, spiritual and mental development. Breastfeeding not only has a biological effect on the mother and baby, but also has an emotional effect and has many immunological, psychological, social and economic benefits for both mother and baby. Therefore, it is of great importance that the baby be fed exclusively with breast milk for the first 6 months and that breastfeeding continues until the age of 2.

EFT, a needle-free and emotional form of acupuncture, is an energy technique that emerged from the idea that "The cause of all negative emotions is the disruption in the body's energy system." EFT; It can be safely applied to individuals of all ages, including the elderly, pregnant women and children. When looking at the literature, no studies were found regarding breastfeeding and EFT. It has been observed that primiparous women, especially those who have had a cesarean section, have difficulty breastfeeding. It is thought that breastfeeding will be reinforced and improved with EFT, which helps to eliminate negative emotions in the subconscious and create a positive mood.

Eligibility Criteria:
Inclusion Criteria:

* Being between the ages of 18-35,
* Primiparous and giving birth by cesarean section,
* Having a spontaneous pregnancy,
* Wound, scar, infection etc. in the tapping area. without conditions,
* Women who do not have verbal communication problems

Exclusion Criteria:

* Being outside the age range of 18-35
* Has any problem that prevents communication,
* Those who gave birth normally
* Having had a high-risk pregnancy,
* Women who want to leave the study
Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.

This study aimed to evaluate the efficacy of Pulsed electromagnetic field (PEMF) for Chronic sinusitis in a randomized, double-blind, placebo-controlled trial.

Chronic sinusitis, or chronic rhinosinusitis, is an inflammatory condition defined by symptomatic inflammation of the paranasal sinuses lasting longer than 3 months. Common presenting symptoms include nasal obstruction, facial pressure or fullness, nasal discharge (anterior or posterior), and olfactory loss. Furthermore, chronic sinusitis is associated with reductions in patient quality of life, sleep quality, and daily productivity.

A pulsed electromagnetic field (PEMF) has an anti-inflammatory, antimicrobial, and improves the microcirculation of the mucosal membrane of the nasal cavity. It has been suggested that magnetic therapy can be used in treating chronic sinusitis but there is a scarce of studies about its usage.

Eligibility Criteria:
Inclusion Criteria:

* patients suffering from mild to moderate symptoms of rhinosinusitis.

Exclusion Criteria:

* pregnant or breastfeeding women.
* patients with definite deviated nasal septum, sinusitis, or history of operation within the last 6 months.
* patients with hypertension, diabetes mellitus, malignancy, active pulmonary tuberculosis, infection, active respiratory disease like asthma, or other systemic diseases.
* patients with long-term use of corticosteroids or immunosuppressive agents.
* patients who were involved in another clinical study within 30 days.
* patients who were unable to comply with the follow-up schedules.
* patients who had used antihistamines within 1 week, topical corticosteroids within 2 weeks, systemic corticosteroids within 4 weeks, anti-cholinergic drugs within 3 days, antileukotriene drugs within 1 week, decongestants within 3 days, tricyclic antidepressants or phenothiazines within 2 weeks, non-steroidal analgesics within 2 weeks, and other drugs which the researchers believed were inappropriate.
Dermacyd PH_DESILSTY_FR (Lactic Acid) - Photo Evaluation - Stay on Frutal

Primary Objective:

To demonstrate the absence of photoirritation and potential photosensitization of the product Dermacyd PHDESILSTYFR.


Eligibility Criteria:
Inclusion criteria:

* Phototype Skin II and III Integral skin test in the region
* Willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion

Exclusion criteria:

* Lactation or pregnancy
* Use of Antiinflammatory 30 days and/or immunossupression drugs until 3 months before volunteers selection
* Disease which can cause immunosuppresion, such as diabetes, HIV
* Concomitant use of photosensitivity drugs
* History of sensitivity or photosensitivity with topic products
* Cutaneous active disease which can modify the study results
* History or activity of photodermatosis
* Personal or family antecedents of cutaneous neoplasia photo induced
* Presence of injury precursor of cutaneous neoplasia, such as melanociticos nevus and actinic keratosis
* Intense exposure solar in the test region
* Use of new drugs and/or cosmetics during the study
* Previous participation in studies using the same product in test
* Relevant history or confirmation of alcohol or other drugs abuse
* Intolerance detected or suspected for some component of the sample tested
* Medecin or sponsor employees or their close family.

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit

This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.

Study 1: senventy-one male and female participants, aged 23.99 ± 5.68 years were randomly assigned into 3 groups including 1) control group (n = 23): participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks 2) treatment-1 group (n = 23): participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks and 3) treatment-2 group (n = 25): participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks.

Study 2: fifty-nine male and female participants, aged 23.39 ± 4.84 years were randomly assigned into 2 groups including 1) control group (n = 29): participants did not receive any facial mask for 12 weeks and 2) treatment group (n = 30): participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.

Study 3: this study was divided into 2 sub-stidies. Study 3.1: twenty-five male and female participants, aged 22.60 ± 3.33 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. All participants were analyzed for blood glucose level before consumption and after consumption at 30, 60, 90, and 120 min. Study 3.2: twenty-three male and female participants, aged 21.57 ± 1.88 years were randomly consumed with either control jelly or jelly with Snake fruit juice at 3.5 g/kg body weight. After each consumption, all participants performed leg cycling at intensity 60% of maximal oxygen consumption as long as tolerance (time to exhaustion test).

Eligibility Criteria:
Inclusion Criteria:

* Man or woman
* Aged between 18 to 35 years
* Healthy
* Interested in body massage with oil or facial mask or jelly from Snake fruit

Exclusion Criteria:

* History of adverse effects from body massage
* Skin allergy
* Skin disorders
* Skin wounds
* History of allergy to coconut or plant oil
* History of allergy to facial mask, i.e., mask from fruit
* History of allergy to Snake fruit or gelatin
* Signs or symptoms of fever or infection
* Abnormal body mass index
* Regular smokers or alcohol drinkers (\>2 times per week)
* Regular exerciser (\>2 times per week or \>150 min per week)
* Regular intake of dietary supplements, i.e., vitamins, antioxidants
* Hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer
A Trial on the Effect of Emotional Disclosure of Traumatic Life Events on Physical Health

This is a randomized, controlled trial on the effect of emotional disclosure of traumatic life events on physical health. The hypothesis is that expression of emotions could possibly improve physical health.


Eligibility Criteria:
Inclusion Criteria:

* healthy

Exclusion Criteria:

* any mental or physical illnesses in the last three months
Intramuscular Injection of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles

This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with frozen embryo transfer. The study population in frozen embryo transfer cycles receive three doses of human chorionic gonadotropin (HCG) to recognize the effectiveness of HCG on pregnancy outcomes in Reproductive Biomedicine Research Center, Royan institute, Tehran Iran.

During implantation, the biochemical crosstalk between the endometrium and embryo has a very important role. The endometrium secrets cytokines and growth factors that modulate embryonic differentiation and early development. One of the important molecular messages between the embryo and endometrium is human chorionic gonadotropin (HCG). HCG is expressed by the blastocyst before the implantation, while increasingly produced after implantation by the syncytiotrophoblast. In order to study the direct effect of HCG on the endometrium at implantation, this randomized, controlled clinical trial evaluated whether HCG supplementation would be beneficial for pregnancy outcomes of cryopreserved-thawed embryo transfer with estrogen/ progesterone replacement cycles at Royan Institute.

Block randomization method is designed by epidemiologist using STATA software version 13 and the number of blocks considered is 6. The random allocation list for patients is solely available to the epidemiologist. In order to hide the random allocation process, a total of 200 envelopes are prepared, and only the methodologist has been aware of table of random numbers. When the doctor declared the patient's eligibility, the methodologist provided the doctor with the envelope. The group will be selected and based on the type of group mentioned in the envelope.

Eligibility Criteria:
Inclusion Criteria:

* Infertile women candidates for frozen embryo transfer
* Age 20-40 years
* Body Mass Index under than 30 Kg/m2
* Having at least three good quality embryos

Exclusion Criteria:

* Women with hematologic and autoimmune disorders
* Couples with chromosomal and genetic abnormalities
* Women with uterine anomalies
* Women with uterine and ovaries surgical history
* Women with endometriosis and adenomyosis
* Women with hydrosalpinx
* Women with uterine fibroids
* Women with history of recurrent abortion or recurrent implantation failure
* Severe male factor infertility (azoospermia)
* Embryo donation cycle
* Endometrial thickness less than 8 millimeter on the day of embryo transfer
Universal Screening for Maternal Depression With the CHICA System

The CHICA system is a clinical decision support system that uses adaptive turnaround documents to provide point-of-care information to clinicians. We will be studying whether it can help in the diagnosis and referral of mothers with maternal depression.


Eligibility Criteria:
Inclusion Criteria:

* All families of patients age 0 to 15 months

Exclusion Criteria:

* None
Hemodynamic Parameters in People with Atherosclerotic Vascular Disease Referred to a Secondary Prevention and Cardiovascular Rehabilitation Program

The main purpose of this study is to evaluate the hemodynamic changes in the forefoot of patients with coronary, cerebrovascular or peripheral atherosclerotic disease referred a 12-week cardiovascular rehabilitation program (PREV program).

Also, this study will describe the characteristics of patients admitted to the PREV program and their evolutions in terms of favorable, unfavorable outcomes and complications and up to one year after completion of the program.


Eligibility Criteria:
Inclusion Criteria:

* Any individual aged 18 years and older who has been diagnosed with peripheral artery disease, coronary artery disease, angina, ischemic heart failure, transient ischemic attack or ischemic stroke (non-cardioembolic, non-hemorrhagic);
* Have been admitted to the PREV program;

Exclusion Criteria:

* Being not able to give written informed consent;