cyrilzakka/clinical-trials huggingface dataset:
Preemptive Genotyping and Pain Management

The purpose of this study is to see if testing for genes related to pain and pain management before surgery affects how patients are treated for pain after surgery. The investigators want to know if this information will be used to effectively treat patients for pain after surgery if the clinical staff have a chance to review it before the surgery.

Purpose: To determine the feasibility of preemptive (preoperative) cytochrome P450 isoenzyme (CYP2D6) testing and the variability of clinical measures (postoperative) in children whose opioid selection and dosing is influenced by preemptive CYP2D6 testing compared to children whose pain management does not include CYP2D6 preemptive testing. Results from this pilot study will inform a future study investigating the utility of preemptive pharmacogenomic testing in children at risk for requiring inpatient acute pain management with opioids.

Eligibility Criteria:
Inclusion Criteria:

* Children, 6-17 years of age and adults, 18 - 21 years with idiopathic scoliosis and/or pectus excavatum scheduled for surgical clinic visit
* BMI \< 30
* Cognitively able to use a 0 - 10 numerical rating scale (NRS) to report level of pain
* Parents give permission (and children give assent when appropriate) or adult participants give consent for CYP2D6 results to be placed in Cincinnati Children's Hospital Medical Center (CCHMC's) EPIC

Exclusion Criteria:

* • Who had prior surgery for idiopathic scoliosis and/or pectus excavatum

  * Who have prior CYP2D6 testing or Genetic Pharmacology Service (GPS) Psychiatry Panel documented in EPIC
  * Who are taking prescription medication known to inhibit or induce CYP2D6
  * Who are taking prescription medication known to inhibit (e.g. voriconazole) or induce (e.g. carbamazepine and rifampin) CYP3A4
  * Who have liver or renal failure
  * Who have history of narcotic abuse
What we Think About the Do-not-resuscitate Order: Survey Study

The do not resuscitate (DNR) order is a decision taken by the patient or other people about medical care in the end stages of life to withhold CPR in event of respiratory or cardiac arrest and allow natural death to occur. There is currently no related article of law to DNR order in Turkey. It was aimed to evaluate the health workers(HW) and the non health workers'(NHW) knowledge, attitude, and behavior related to the do-not-resuscitate (DNR) order in Turkey.

The do not resuscitate (DNR) order is a decision taken by the patient or other people about medical care in the end stages of life to withhold CPR in event of respiratory or cardiac arrest and allow natural death to occur. There is currently no related article of law to DNR order in Turkey. A questionnaire with 25 questions has been distributed to health workers and non-health workers.

It was aimed to evaluate the health workers(HW) and the non health workers'(NHW) knowledge, attitude, and behavior related to the do-not-resuscitate (DNR) order in Turkey.

Eligibility Criteria:
Inclusion Criteria:

* Adults ≥18 years of age
* People who are able to complete the questionnaire

Exclusion Criteria:

-
Monitoring Movement Disorder Symptoms With a Mobile Medical App on Off-the-shelf Consumer Mobile Devices

The purpose of this study is to evaluate whether New Touch Digital (NTD) NeuroRPM software installed on wearable devices can objectively measure and track symptoms in patients with Parkinson's disease.


Eligibility Criteria:
Inclusion Criteria:

1. Subject is 18 years of age or older
2. Subject is able to provide informed written consent
3. Subject has been clinically diagnosed with Parkinson's Disease
4. Subject is mentally and physically capable of performing tasks on the mobile device and related physical activities herein described

Exclusion Criteria:

1. Inability to give informed consent
2. Presence of additional neurological disease aside from the diseases being studied
3. Inability to understand and follow the directions for the study
Dose-Finding, Feasibility Study of Optison in Contrast Enhanced U/S for the Detection of Carotid Artery Disease

The purpose of this study is to find the optimal dose from 3 different dose levels - 0.15 mL, 0.5 mL and 1.5 mL of Optison in assessing the presence of disease of the carotid arteries when comparing pre-contrast to post-contrast ultrasound (U/S) by dose group.


Eligibility Criteria:
Inclusion Criteria:

* The subject is is greater than or equal to 18 years of age.
* The subjects has highly suspected or established carotid artery disease.
* The subject has undergone or been referred for either unilateral or bilateral intra-arterial X-ray carotid angiography for the determination of subject management (within 30 days before or after the U/S procedure).
* The subject has non-diagnostic U/S of the carotids as defined by institutional standards.

Exclusion Criteria:

* The subject presents any clinically active, serious, life-threatening disease, with a life expectancy of less than 1 month or where study participation may compromise the management of the subject or other reason that in the judgment of the investigator makes the subject unsuitable for participation in the study.
* The subject has a history of acute occlusion requiring medical intervention of any artery (including aorta) within 6 months of consent.
* The subject has a known or suspected hypersensitivity to any of the components of Optison, blood, blood products, or albumin.
* The subject has right to left, bi-directional or transient right to left cardiac shunts.
Effects of Incorporating Sprouted and Non-sprouted Chickpea Flour in Pasta Products Analyzed in Vivo Flow-mediated Dilation

The investigators examined the effects on post-digestion brachial artery flow mediated dilation (FMD) and in vitro antioxidant capacity of 40% semolina flour replacement with sprouted chickpea flour.

The purpose of the current study was to examine in-vitro and in-vivo effects of replacing 40% of semolina flour with sprouted chickpea flour for the use in pasta. Antioxidant capacity in-vitro was measured by Trolox Equivalent Antioxidant Capacity. Brachial artery flow-mediated dilation, a test of in-vivo endothelial function, was performed for assessment of effects on post-digestion endothelial function. The investigators hypothesized that FMD would be higher after consuming 40% of semolina flour with sprouted chickpea flour pasta vs. 100% of semolina flour pasta.

Eligibility Criteria:
Inclusion Criteria:

* healthy adult

Exclusion Criteria:

* have diabetes mellitus, kidney disease, a history of cancer, cardiac issues, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions.
* food allergies relevant to wheat, gluten, chickpea, and pasta sauce.
* are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
* are unable or unwilling to refrain from recreational drug (marijuana, cocaine, etc.) or alcohol use during the 24 hours prior to your exercise session.
* use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
* are pregnant or trying to become pregnant.
The Role of oAncreatic Enzyme ReplAcement Therapy (PERT) on Mucosal Visibility Before Upper GI Endoscopy

The investigators aim to establish wether the administration of pancreatic enzyme replacement therapy (PERT) improves visibility of the mucosa during upper gastrointestinal endoscopy.

Upper gastrointestinal endoscopy is done "a jeun", without any solid foods at least 8 hours before procedure and no water at least 2 hours before procedure.

Often, the visibility of the mucosa is suboptimal due to presence of saliva which lay on the surface of the gastric mucosa forming small bubbles of foam and also the presence of mucus on the mucosal surface. Current strategies to improve mucosa visibility includes ingestion of simethicone, N-acetyl cysteine (N-ACC) an/or pronase, in different combinations, with 10 to 30 minutes before procedure. There are numerous comparative studies which shows their efficacy \[1,2,3,4\].

Although the guide of the European Society of Gastrointestinal Endoscopy (ESGE) \[5\] does not formally recommend these, the United Kingdom and the Australian guidelines do formally recommend them \[6\].

În România simethicone is available, but not pronase.

Research question of the protocol Does ingestion of a pancreatic protease (KREON 25000 UI) before upper GI endoscopy improves the visibility of the gastric mucosa.

Hypothesis Ingestion of a pancreatic protease (KREON 25000 UI) before upper GI endoscopy improves the visibility score of the gastric mucosa.

Eligibility Criteria:
Inclusion Criteria:

* patient with upper gastrointestinal endoscopy indication, with topical pharyngeal anesthesia
* age above 18 years old
* informed consent

Exclusion Criteria:

* allergy to KREON and/or sodium bicarbonate
* upper gastrointestinal bleeding clinically manifest (hematemesis, melena, hematochesia)
* ingested foreign body
* personal history of esophagectomy, partial or total gastectomy
* absence of informed consent
The Usability, Acceptability, and Perceived Value of the Cornerstones4Care Powered by Glooko App

This is a two-armed mixed methods study of participants (n=30) diagnosed with type 2 diabetes who use a blood glucose meter as part of their treatment regimen. Participants will have either two or three visits at HITLAB during the 28-day study period.

The purpose of this study is to evaluate the utility and user experience of a mobile application, called Cornerstones4Care Powered by Glooko App (C4C), for persons diagnosed with diabetes type 2.Subjects will be asked to use the Cornerstones4Care Powered by Glooko App for an approximately 20 minute monitored demonstration session, followed by a 28-day period of daily engagement with the application.The Cornerstones4Care Powered by Glooko App lets users input nutrition, medication, exercise and other daily information to assist in the management of diabetes type 2. It also has the ability to sync with connected devices, such as blood glucose monitors. Additionally, the application offers a library of educational content for users.

Eligibility Criteria:
Inclusion Criteria:

1. Be diagnosed with type 2 diabetes
2. Live in the New York Metropolitan area
3. Be at least 18 years of age
4. Able to read, write, and speak in English
5. Have an iPhone or Android phone
6. Use a blood glucose meter
7. Regularly take insulin by injection
8. Be willing to follow study requirements for a 28-day period

Exclusion Criteria:

1. Not be diagnosed with type 2 diabetes
2. Not living in the New York Metropolitan area
3. Be less than 18 years of age
4. Be unable to read, write, and speak in English
5. Not have an iPhone or Android phone
6. Not use a blood glucose meter
7. Not regularly take insulin by injection
8. Be unwilling to follow study requirements for a 28-day period
Juvenile Autoimmune Necrotizing Myopathies

Autoimmune necrotizing myopathies (AINM) in adult patients are characterized by severity of muscle damage, presence of necrosis with little inflammation on muscle biopsy and anti-HMGCR or anti-SRP auto-antibodies. Data on AINM in children are currently lacking. The purpose of this study is to specify the characteristics at AINM diagnosis, treatments and evolution of juvenile AINM with anti-HMGCR or anti-SRP antibodies.


Eligibility Criteria:
Inclusion Criteria:

* AINM histologically proved by predominant muscle fibers necrosis lesions associated with minimal or absent inflammatory lesions
* Either anti-SRP or anti-HMGCR antibodies positivity
* Disease onset before age 18

Exclusion Criteria:

* Seronegative necrotizing myopathies
* Forms compatible with another type of myositis (e.g. dermatomyositis)
Carac & PDT Combination in the Treatment Of Actinic Keratoses

To demonstrate if Carac treatment after PDT treatment of actinic keratoses leads to superior clinical improvement when compared to Carac or PDT treatment alone. This will be done by manual counts and through photography.

Carac has been shown to be highly effective for the treatment of actinic keratoses. Photodynamic Therapy (PDT) has also been shown to be highly effective for the treatment of actinic keratoses. Both treatments are FDA approved. The mechanism of action of each therapy is different. In general a more vigorous, but less cosmetically acceptable appearance is seen after Carac treatment as compared to PDT treatment. The purposes of this study are to determine 1) If the use of Carac, followed by PDT treatment, of actinic keratoses leads to an enhanced clinical improvement as compared to PDT treatment alone; 2) If the cosmetic appearance of the skin during Carac is improved with PDT pre-treatment; 3) Evaluate histologic changes induced by combined Carac/PDT treatment as compared to Carac treatment alone and PDT treatment alone.;4) Evaluate safety of treatments in terms of potential for infection and scarring

Eligibility Criteria:
Inclusion Criteria:

* Males/females,, aged 40-70
* Must have 5 or more documented facial/anterior scalp actinic keratoses
* Read, understood, and signed informed consent form
* Willing and able to comply with all follow-up requirements

Exclusion Criteria:

* Previous treatment of facial keratoses with any modality of treatment within 3 months of study enrollment
* Contraindications to the use of either Carac and/or PDT treatment
* Exclusion of biopsy proven skin cancer in the area
* Active infections or dermatitis in the treatment area
Adrenal Tumors - Pathogenesis and Therapy

The pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. The current study investigates different aspects of the pathogenesis of adrenal tumors and evaluates different therapeutic options in patients with adrenocortical carcinoma.


Eligibility Criteria:
Inclusion Criteria:

* adrenal tumor detected by imaging

Exclusion Criteria:
Combined Effects of Core Stability Exercises and Back Strengthening Exercises on Pregnancy-Induced Back Pain.

The study will be a Randomized controlled trial to check the combined effects of Core Stability Exercises with and without Back strengthening exercises in females with pregnancy-induced back pain, disability, and function so that we can examine the effect of the above techniques on pain, disability and function in pregnant females Non-probability convenience sampling technique will be used, subject following eligibility criteria from Society Hospital Nabipura Lahore will be randomly allocated in two groups. Group A participants will be given core stability exercises with back strengthening exercises, Group B participants will be given core stability exercises for 4 weeks. Assessment will be done via, Numeric Pain Rating Scale, Oswestry disability index questionnaire and Back pain Functional Scale.

Pregnancy-inducedBack pain causes weakness of abdominal muscles and pelvic muscles which affects core stability and back strength of pregnant women. In this study, the effects of Core Stability Exercises with and without Back strengthening exercises in pregnancy-induced back pain population will be analyzed. This study will be a randomized controlled trial. Core stability exercises and Strengthening exercises program would be applied to pregnant females with pregnancy-induced back pain. Subjects meeting the predetermined inclusion criteria will be divided into two groups. Assessment will be done using the Numeric Pain Rating Scale (NPRS), Oswestry Disability Index Questionnaire, and Back Pain Functional Scale (BPFS). Subjects in one group will be treated with core stability exercises with back strengthening exercises, and the other will be treated with core stability exercises only. Each subject will receive a total of 20 treatment sessions, with 05 treatment sessions per week. Measurements will be recorded at the start and end of the treatment session. Recorded values will be analyzed for any change using SPSS.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant females
* Pregnant female in their second and third trimester.
* Multi gravida patient
* Low back pain intensity greater than 4 out of 10 on NPRS, indicating moderate to severe.

Exclusion Criteria:

* Placenta previa
* Bleeding or spotting
* Low back pain before pregnancy
* Pregnancy-induced hypertension
* Pudendal nerve entrapment syndrome.
* Not simultaneously partaking in pelvic floor physical therapy.
* No evoked tenderness upon palpation of levatorani sling at examination.
High Dose Radiation Therapy With Concurrent Chemotherapy in Locally Advanced Non-small Cell Lung Cancer

To assess the efficacy and feasibility of high-dose intensity-modulated radiotherapy with concurrent weekly paclitaxel and cisplatin for patients with locoregionally advanced non-small lung cancer.

Local failure remains high in patients with locoregionally advanced non-small lung cancer. Given that a biological equivalent dose (BED)more than 100 Gy yields approximately a local control rate of 90% in early-stage non-small lung cancer, this BED or ever higher is logically required to control local disease for locally advanced non-small lung cancer. However, dose escalation is limited by radiation-related toxicity. Use of hyperfractionated radiation Therapy boost to residual metabolic disease as defined by positron emission tomography and computed tomography (PET/CT) immediately after standard chemoradiotherapy (SCRT) using image-guided (IG) IMRT could potentially improve local control and perhaps survival

Eligibility Criteria:
Inclusion Criteria:

* Patients must have FDG-avid and histologically or cytologically proven non-small cell lung cancer.
* Age 1 8-75.
* Eastern Cooperative Oncology Group （ECOG） performance status 0 to 2.
* Stage III ( American Joint Committee on Cancer AJCC, 7th ed.).
* No prior radiation to the thorax that would overlap with the current treatment field.
* Adequate bone marrow, renal and hepatic functions as assessed by the following: Hemoglobin \>/= 10.0 g/dl, Platelet count \>/= 1 00,000/ mm\^3,absolute granulocyte count (AGC) ≥2 × 10\^9 cells/L,bilirubin and Aspartate transaminase ≤1.5 ×upper limit of normal (ULN), Creatinine \</ =1 .5 times ULN.
* A signed informed consent must be obtained prior to therapy.
* Induction chemotherapy is allowed.
* Life expectancy more than 3 months

Exclusion Criteria:

* Patients with any component of small cell lung carcinoma are excluded from this study.
* Patients with evidence of a malignant pleural or pericardial effusion are excluded.
* Prior radiotherapy that would overlap the radiation fields.
* Uncontrolled concurrent illness including, but not limited to: Chronic Obstructive Pulmonary Disease(COPD) exacerbation or other respiratory illness, serious uncontrolled infection, symptomatic congestive heart failure (CHF),unstable angina pectoris, uncontrolled hypertension,or psychiatric illness/social situations that would limit compliance with the study requirements.
* Known hypersensitivity to paclitaxel.
* Any other condition or circumstance that would, in the opinion of the Investigator, make the patient unsuitable for participation in the study.
* Conditions precluding medical follow-up and protocol compliance
Postoperative Pain Endodontic Retreatment

To compare the incidence of post-operative pain after single-visit versus two-visit non-surgical endodontic retreatment.

Post treatment failure could be treated by two options including orthograde retreatment and apical surgery . In a previous study, orthograde retreatments presented a success rate of 81 % classified as healed and 93 % as no symptoms and fully functional. In a systematic review, it has also been concluded that endodontic surgery offers more favorable initial success but orthograde retreatment yields to a better long-term outcome . Although early results of single-visit treatments are contradictory ; Completing the treatment in a single appointment reduces the treatment time and cost, decreases micro leakage risk and avoids recontamination of root canals between appointments in multiple-visit treatments . Again, reviewing the literature concerning primary treatment showed that, no significant differences were observed in healing of periapical radiolucency between teeth treated in single-visit and those treated in two-visits. Even, after using calcium hydroxide for four weeks . The presence of a positive bacterial culture at the time of filling did not influence the outcome of treatment .

Thorough online search revealed that, few studies are found concerning post- operative pain after single visit retreatment . The present study is designed to compare the effects of single-visit and two-visit root canal treatments on postoperative pain in retreatment cases. The primary outcome measure of this study is proposed to be whether single-visit root canal retreatment influenced the occurrence of postoperative pain as compared to two-visit treatment.

Eligibility Criteria:
Inclusion Criteria:

* Clinically asymptomatic.
* Previously treated teeth in need of retreatment due to leakage and/or improper filling.
* No periapical radiolucency.
* No percussion pains.
* Age 20 - 45.
* Premolar teeth.
* Male \& female.

Exclusion Criteria:

* Complicating compromised patient.
* Tenderness to percussion and acute apical abscess.
* Presence of an associated sinus tract.
* Presence of swelling in adjacent soft tissue.
* Teeth with periodontal pathologies or mobility.
* Teeth representing root fracture.
* Pregnant women.
* If analgesics or antibiotics have been administrated by the patient during the past 24 hours.
Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis

The antifungal efficacy and safety of Jublia® topical solution will be assessed through an administration for 48 weeks to patients diagnosed with a mild or moderate onychomycosis due to dermatophyte.

Evaluate anti-fungal activity and safety of efinaconazole in patients with mild to moderate toenail onychomycosis caused by dermatophytes that received a 48-week administration of efinaconazole.

Eligibility Criteria:
Inclusion Criteria:

* Adult male and female subjects of ages in the range over 19.
* The subjects diagnosed with onychomycosis in up to 6 toenails at least

  1 great toenail woth no fingernails
* The subjects diagnosed with a mild to moderate onychomycosis (20% to 50% of surface of target nail without nail matrix infection or dermatophytoma)
* The subjects having target nails less than 3mm in thickness and over 3mm in length
* Positive indication on KOH Direct Microscopic Inspection on target nail
* Positive dermatophyte or dermatophyte/candida on Fungi Cultivation Inspection on target nail
* The subjects completely understood the clinical trial through detailed explanation presented, determined to participate in the clinical trial spontaneously, and agreed to observe precautions suggested thereby through written consent.

Exclusion Criteria:

* The subjects suffering other diseases that may cause nail abnormalities or are supposed to be affecting the assessment of the efficacy of study agent by the judgment of investigators
* The subjects having a case history of hypersensitivity reaction to the component of Jublia® topical solution or Azole derivatives.
* The pregnant, lactating, or fertile woman free from pertinent contraception