cyrilzakka/clinical-trials huggingface dataset:
Assignment of Alcohol Drinks to CIDI Drink Categories

Alcohol consumption is a prevalent behavior in Western societies, which may produce feelings of happiness and sociability, but also increases the risk of individual and societal detriments. A detailed knowledge about individual and region-specific alcohol consumption is crucial in many aspects of health systems, from general practitioner's diagnostic evaluation to decisions on health-care related fundings for prevention programs by legislative and executive councils.

The assessment of alcohol consumption often consists of questions like "What alcohol and in which amount did you drink lately?" which may be answered using a given list of prevalent alcoholic beverages. With this study, the investigators want to contribute to the understanding of psychological determinants in answering these questions. For example, it is not yet fully understood, to which extend and why certain beverages are assigned to one of several beverage groups. The investigators suspect that familiarity with specific beverages as well as product names may influence this assignment.

In this online survey, which is open to any German-speaking alcohol user no matter how often or how much alcohol one normally consumes, participants will be presented a list of common beverages (e.g. Cuba Libre, Prosecco, Weizen) and asked to assign these beverages to one of several beverage groups (e.g. whiskey, beer, sparkling wine).

The investigators expect that alcohol users will assign alcoholic drinks based on the product names, which might lead to erroneous assignments to predefined drink groups in certain occasions (e.g. "Bierlikör - beer liquor"). Furthermore, it is hypothesized that this tendency is smaller the more familiar a user is with the drink. Lastly, it is hypothesized that drinks with relatively low use prevalence in the general population, e.g. sweet liquors and cocktails, and drinks that include alcohol mixed with non-alcoholic beverages (e.g. "Radler", a beer-lemonade mix), are more often subject to non-concordant assignment across participants compared to highly-prevalent drinks (e.g. "Pilsner").

Thus, the investigators expect alcohol users to:

1. assign \>90% of the presented beverages correctly,
2. differ from the expert assignments especially in drinks they are not familiar with,
3. differ from the expert assignments especially in drinks with ambiguous names,
4. do not differ in their assignments based on their gender and age group.

Eligibility Criteria:
Inclusion Criteria:

* Lifetime-consumption of any of the 60 presented alcoholic beverages,
* Consumption of 12 or more alcoholic drinks past year,
* Ability to understand and accept the informed consent, to answer the presented questions and fill out all questionnaires

Exclusion Criteria:

* Multiple participation in this study
* not answering at least one presented questionnaire (60-beverages-questionnaire, assignment-questionnaire, AUDIT questionnaire, sociodemographic questionnaire)
Nutritional Status of prEgnant Women Following BariatrIc surgEry

The aim of this observational study is to learn more about nutrient status during pregnancy after bariatric surgery. All pregnant women older than 18 years who underwent bariatric surgery and sought obstetric care within one of the participating hospitals were included and followed up until 2 months post-partum.


Eligibility Criteria:
Inclusion Criteria:

* Older than 18 years
* Medical history of metabolic bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy)

Exclusion Criteria:

* Elective termination of pregnancy
* Multiple pregnancy
* Metabolic bariatric procedures other than Roux-en-Y gastric bypass or sleeve gastrectomy
* Reversal of the bariatric procedure
* Malnutrition due to other causes (e.g., malignancy, alcoholism)
Pattern of Growth and Characteristics of Down Syndrome Pediatrics Patients

Down syndrome or Down's syndrome (DS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45 .

People with DS may have some or all of these physical characteristics: a small chin, slanted eyes, poor muscle tone, a flat nasal bridge, a single crease of the palm, and a protruding tongue due to a small mouth and relatively large tongue. Other features include: a flat and wide face, a short neck, excessive joint flexibility, extra space between big toe and second toe, abnormal patterns on the fingertips and short fingers. Short stature is a characteristic feature of DS. Growth retardation of DS individuals starts prenatally. After birth, the growth velocity is most reduced between 6 months to 3 years . Growth charts specific for children with DS are important tools for routine medical follow-up, as well as early identification of pathological causes of growth retardation, and monitoring of growth promoting treatments. Growth charts for DS are available from different countries, for example, Italy, USA, Denmark, Sweden, Portugal, France, UK and Ireland and Saudi Arabia .

Eligibility Criteria:
Inclusion Criteria:

* All Down syndrome children attending Assuit university less than four years with or without cardiovascular.

Exclusion Criteria:

* Any Down syndrome child more than four years.
Comparison of Endotracheal Tube Fixation Methods in Prone Position

In particular, prone position surgeries risk potentially life-threatening ET tube dislocation. Failure to place the plaster used for ET tube fixation correctly and adequately in this position may contaminate the patch with body fluids and loosen the weight of the breathing circuit, causing the ET tube to slip and dislodge. Adhesive tape (plaster), bandage (non-adhesive), suturing, or a commercially available tube holding device are recommended for ET tube fixation in patients operated in the prone position. In addition, the adhesive plasters used can be taped on the patient's face to the maxilla, mandible, or both. Because of the urgent and critical settings, a fast, reliable, and easy-to-use method of ET tube fixation is invaluable as it will provide clinicians with greater confidence in the stability of alternative airways and reduce complications from airway maintenance. In our clinic, different fixation methods are used according to the experience and preference of the anesthesiologist. Our study aims to compare other fixation methods using FOB to fix the position of the ET tube with an appropriate method in prone position procedures and ensure that patients have safe airway management throughout the surgery.


Eligibility Criteria:
Inclusion Criteria:

* ASA Physical Status I-II
* Mallampati score I-II

Exclusion Criteria:

* Patients who did not want to participate in the study
* Restricted mouth opening
* BMI ≥ 35 kg/m2
* Risk of airway malformation and aspiration (gastroesophageal reflux, hiatal -hernia, history of previous gastric surgery, GIS motility disorder)
Assessing Fermentability of a Dietary Fiber

The objective of this study is to provide evidence for its fermentability of a dietary fiber and to collect information regarding potential health opportunities for glucose control as well as tolerability when being consumed over 7 days.

This study is designed as a randomized, 2-arm, treatment-controlled, within-subjects, 8-hour postprandial crossover study, utilizing a multiple sampling paradigm to evaluate fermentability and potential health opportunities for glucose control of a dietary fiber (FCHO) in healthy non-obese men and women. The study will include 2 - 8 h assessments following consumption of the FCHO drink or a placebo drink and will follow with a 7 day feeding period to assess tolerability.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* BMI between 18.5 and 29.9 kg/m2, inclusive
* No clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease
* No diabetes
* No Gastrointestinal issues

Exclusion Criteria:

* Pregnant and/or lactating or planning for pregnancy
* Allergies or intolerances to foods consumed in the study Fasting blood glucose \> 125 mg/dL.
* Vegetarian
* Taking over the counter fiber supplements or other supplements that may interfere with the study procedures or endpoints
* Taking actively probiotics or purposely taking/ subscribing to a diet high in prebiotics.
* Taking prescription medications that may interfere with study procedures or endpoints (eg., antibiotics)
* Subjects with unusual dietary habits (e.g. pica)
* Actively losing weight or trying to lose weight (unstable body weight fluctuations of \> 5 kg in a 60 day period)
* Excessive exercisers or trained athletes
* Addicted to drugs and/or alcohol
* Medically documented psychiatric or neurological disturbances
* Smokers (past smokers may be allowed if cessation is \> 2 years)
Protective Ventilation During Pulmonary Lobectomy

The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in patients undergoing one-lung ventilation for pulmonary lobectomy.

The hypothesis is that application of low tidal volume, moderate inspired oxygen fraction (FiO2) ,intermittent alveolar recruitment and positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in patients.

Eligibility Criteria:
Inclusion Criteria:

1.20 Years and older 2.Patients undergoing pulmonary lobectomy

Exclusion Criteria:

1. Emergency surgery
2. Pulmonary hypertension
3. Forced vital capacity or forced expiratory volume in 1 sec \< 50% of the predicted values
4. Coagulation disorder
5. Pulmonary or extrapulmonary infections
6. History of treatment with steroid in 3 months before surgery
7. History of recurrent pneumothorax
8. History of lung resection surgery
A Study to Evaluate the Activity, and Safety of Vixarelimab in Participants With Moderate to Severe Active Ulcerative Colitis

This study aims to evaluate the pharmacodynamic (PD) effects of vixarelimab in the gut of participants with active moderate to severe ulcerative colitis (UC).


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of UC established at least 3 months
* Moderately to severely active UC
* Participants must meet criteria for either advanced therapy failure or conventional therapy failure

Exclusion Criteria:

* Diagnosis of Crohn's disease or indeterminate colitis
* Suspicion of ischemic colitis, radiation colitis, microscopic colitis or infectious colitis
* Prior colectomy
* Prior treatment with systemic janus kinase (JAK) inhibitors
A Study of Cabergoline for the Treatment of Cocaine Dependence - 1

The purpose of this study is to assess cabergoline for the Treatment of Cocaine Dependence

To assess the efficacy and safety of cabergoline in reducing cocaine use in subjects with cocaine dependence. This is a DB, placebo-controlled, parallel group design study where subjects will receive either .5mg cabergoline or placebo for 12 weeks with a 4 week follow-up.

Eligibility Criteria:
Inclusion Criteria:

Must have a DSM-4 criteria for cocaine dependence; be seeking treatment for cocaine dependence; have the ability to understand and provide written informed consent; females of child-bearing potential using proper method of birth control.

Exclusion Criteria:

Additional criteria available during screening at the site.
Evaluation of a Walking School Bus Program

Just two generations ago, walking or bicycling to school was the norm for a substantial number of US children, e.g. 48% of children walked or biked to school in 1969 versus only 13% in 2009. This decline occurred in the same timeframe as the childhood obesity epidemic, which is at record high levels in the US and affects low-income and ethnic minority children the most. This project will test "the walking school bus" (WSB) program, in which children walk to and from school with adults, and its impact on low-income, ethnic minority children's walking to school, physical activity, and risk for obesity. Ultimately, this line of research has the potential to provide a low-cost, easy to disseminate program to reduce risk of obesity and cancer for at-risk children.

The investigators Specific Aims among 3rd-5th grade children include:

SA1) To recruit 770 child-parent dyads from 22 elementary schools over 4 years and conduct a cluster randomized controlled trial to assess the efficacy of a WSB program on children's walking to school, physical activity, and BMI z-score over a school-year SA2) To collect and analyze data on individual-, school-, and macro-level influences on changes to children's walking to school resulting from the WSB program

The Primary Hypotheses to be tested, in comparison to control children, include:

H1) The WSB program will increase children's walking to school over a school-year.

H1a) Parents' outcome expectations and self-efficacy will mediate the relationship between the WSB and changes to children's walking to school.

H1b) Walkability, safety, and acculturation will moderate changes to children's walking to school.

H2) The WSB program will increase children's physical activity and decrease BMI z-scores over a school-year.

H3) The WSB program will increase school-level pedestrian safety behaviors over a school-year.


Eligibility Criteria:
Inclusion Criteria:

* physically capable of walking to and from school
* live within 1-mile of school or parents agree to regularly drop off children within 1-mile of school
* attend a study school and enrolled in 3rd, 4th, or 5th grade

Exclusion Criteria:

* another child from the same household is enrolled in the study
Belgian Screening Project for the Detection of Anderson-Fabry Disease in Hypertrophic Cardiomyopathy

The purpose of this study is to determine the prevalence of Fabry mutations in patients with left ventricular hypertrophy (moderate to severe), as measured by echocardiography.This study is a screening study


Eligibility Criteria:
Inclusion Criteria:

* All patients over 18 years undergoing a routine echocardiography in the participating hospitals
* Both genders will be considered.
* Patients can be included if on 2D echocardiography the maximal septal wall thickness \> 13 mm and/or the posterior wall thickness \> 13 mm. The limit for inclusion is kept relatively low to detect early forms of Fabry cardiomyopathy.
The Pharmacokinetics of Ketorolac Tromethamine Administered Intranasally (IN) for Postoperative Pain in Children Aged 12 Through 17 Years

This was an open-label PK study in pediatric subjects who had undergone general surgery. Each subject's study participation consisted of a screening visit, a single-dose treatment with intranasal ketorolac (IN) tromethamine, and a follow-up visit.

Following surgery, subjects received IN ketorolac 15 mg (weight \< 50 kg) or 30 mg (weight \> or = 50 kg) when pain relief was indicated. For pain not relieved by the study drug, the subjects had access to an opioid analgesic administered by patient-controlled analgesia (PCA). Blood samples for pharmacokinetic analysis were obtained at specified time points following the dose of ketorolac.


Eligibility Criteria:
Inclusion Criteria:

* Children aged 12 through 17 years
* Body weight \> or = 30 kg and \< or = 100 kg
* Female subjects of childbearing potential must have a negative serum or urine pregnancy test result prior to entry into the study
* A legal representative able to provide written informed consent
* Willing and able to comply with all testing and requirements defined in the protocol
* Willing and able to complete the posttreatment visit

Exclusion Criteria:

* Allergy or sensitivity to ketorolac or ethylene diamine tetraacetic acid (EDTA)
* Allergic reaction to aspirin or other NSAIDs
* Had an upper respiratory tract infection or other respiratory tract condition (eg, active allergic rhinitis) that could interfere with the absorption of the nasal spray or with the assessment of AEs
* Use of any IN product within 24 hours prior to study entry
* Clinically significant abnormality on screening laboratory tests
* History of cocaine use resulting in nasal mucosal damage
* History of peptic ulcer disease or gastrointestinal bleeding
* Had advanced renal impairment or a risk for renal failure due to volume depletion
* A history of any other clinically significant medical problem, which in the opinion of the investigator would interfere with study participation
* Participation within 30 days of study entry or within 5 times the half-life, whichever is longer, in another investigational drug study
* Allergy or significant reaction to opioids
* Was pregnant or breastfeeding
* Previously participated in this study
* The surgical procedure involved head, neck, oral, or nasal surgery
Self-Catheterization Mirror System for Female Patients

The purpose of this study is to test a modified mirror system for female patients to use during self-catheterization.

Many female patients have difficulties with self-catheterization. Mirrors currently used for this procedure have limited stability and visibility to easily view the urethral opening during catheterization, particularly for individuals with motor impairments. This can be especially frustrating because catheterization is performed frequently throughout the day and may need to occur at home or in public facilities.

The purpose of this study is to test the usability and efficacy of a modified self-catheterization mirror system for female patients. The modified self-catheterization mirror system makes adjustments to a standard, hospital-provided cathing mirror to help female patients with a range of motor abilities catheterize themselves in various postures and settings. Namely, the system offers (1) an alternative way to hold the mirror, by suspending it between the legs rather than attaching it to the toilet, and (2) lights that can be turned on for improved visibility during the self-catheterization process.

Eligibility Criteria:
Inclusion Criteria:

* Females age 13 or older
* Urinary retention related to spinal cord injury or other medical conditions resulting in need for catheterization
* Individuals with sufficient upper limb function to catheterize independently or with minimal assistance, or as deemed appropriate for the study by the Principle Investigator.

Exclusion Criteria:

* Individuals younger than 13 years old
* Individuals with cognitive deficits or visual impairments that may impact safe use of the devices used
* Severe ROM restrictions of the upper and/or lower extremities
* Pregnant
Preeclampsia and Circulating Biomarkers

In order to assess circulating biomarkers of cardiovascular risk, we will conduct a 10-year follow-up study comparing 32 exposed (women with a history of pregnancy complicated by preeclampsia) and 32 unexposed (women with a history of uncomplicated pregnancy).

Participants will be recruited from a well-characterised cohort, previously assembled during their pregnancies, at the Department of Obstetrics at Randers Regional Hospital in 2001-2004.

Blood and urine samples, collected during their pregnancies, are stored in a biobank, thus rendering the possibility of longitudinal assessment.


Eligibility Criteria:
Inclusion Criteria:

* Participation in previous study 2001-2005.

Exclusion Criteria:

* Current pregnancy or breastfeeding
Intraocular Lens-shell Technique in Phacoemulsification

In this study, the investigators introduce a surgical procedure called "IOL-shell technique" in the purpose of reduce complications of surgeries for dense cataract, and report a prospective randomized controlled study aiming at assessing efficacy and safety of the IOL-shell technique, which showed that the new procedure offered a safer way for hard cataract surgery over the conventional phacoemulsification procedure without compromise in efficacy.

A Prospective, randomized controlled study of 80 eyes with dense nucleus were enrolled. Patients were assigned to two groups: Group I: IOL was traditionally implanted after all nuclear fragments were completely removed, while in Group II, IOL was innovatively implanted in the bag before last residual nuclear fragment was removed. This novel adjusted surgical procedure, featured by using IOL as a protective barrier (named "IOL-shell technique"), not just as a refractive alternative, was conceptual different from the traditional step-by-step procedure. Clinical examinations including uncorrected visual acuity, central corneal thickness (CCT), temporal clear corneal thickness and the corneal endothelial cell density were carried out.

Eligibility Criteria:
Inclusion Criteria:

* Aged 50 years or above
* Dense cataract cases were defined as eyes in which the nuclear color was graded IV or V according to the Lens Opacities Classification System III (LOCS III). Special attention was paid in selecting cases without apparent posterior cortical layer.
* No central corneal opacification
* Pupil diameter \>= 7 mm after full pharmacological dilation in preoperative assessment
* A preoperative central endothelial cell count of \>= 1500 cells/mm2.

Exclusion Criteria:

* Participants with previous intraocular surgery
* Abnormal lens zonules
* Glaucoma
* High myopia (\>-6.0 Diopters)
* Pseudoexfoliation
* Uveitis
* Diabetes mellitus
* Those who were not able to come for follow-up visits.
Trial of Dasatinib in Patients With Advanced Cancers Harboring DDR2 Mutation or Inactivating B-RAF Mutation

The purpose of this study is to establish whether patients with malignancy harboring a discoidin domain receptor 2 mutation or an inactivating B-RAF mutation will respond to dasatinib.


Eligibility Criteria:
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.

Inclusion Criteria

* Diagnosis of advanced malignancy, nonsmall-cell lung cancer (NSCLC) only during stage 1 of accrual.
* Nonsynonymous mutation of B-RAF or DDR2, defined as follows:.

  i) NSCLC with inactivating B-RAF mutation.

ii) NSCLC with discoidin domain receptor 2 (DDR2) mutation.

iii) Malignancy of other histology with DDR2 mutation or inactivating B-RAF mutation, or NSCLC having a B-RAF mutation that is not functionally characterized.

* At least 1 target lesion per Response Evaluation Criteria in Solid Tumors, vol 1.1, on baseline staging evaluation.
* Disease progression after ≥ 1 prior treatment regimen.

Exclusion Criteria

* Pleural or pericardial effusion, Grade \>1.
* QTcF \>470 msec (Grade ≥2) or diagnosed congenital long QT syndrome.
* Absolute granulocyte count \<1500/mm\^3.
* Hemoglobin level \<10 g/dL.
* Platelet count \< 75,000/mm\^3.
* Serum calcium level \<institutional lower limit of normal.
* Hypokalemia, hypophosphatemia, or hypomagnesemia, Grade \>1, despite supplementation.
* Creatinine \>3\*institutional upper limit of normal (ULN).
* Total bilirubin level \>1.5\*ULN.
* Alanine transaminase level \>3\*ULN.
* Other protocol-defined Inclusion/Exclusion criteria apply.