cyrilzakka/clinical-trials huggingface dataset:
Efficacy of Adding Scapular Stabilization Exercises to Postural Correctional Exercises on on Forward Head Posture

The aim of this study is to investigate efficacy of adding Scapular Stabilization Exercises to postural correctional exercises on Endurance of cervical flexor and extensor muscles on Asymptomatic forward head posture.

Forward head posture (FHP) is the most common deviation from ideal head posture and is characterized by the head projecting forward into the sagittal plane such that it is anterior to the trunk. Individuals with neck pain frequently demonstrate FHP, when compared to age-matched controls.

Asymmetric posture is a chronic stressor and the origin of most noxious stimuli that could alleviate 70-90 % of chronic pain. It is reported that FHP is a common postural abnormality, with a conservative estimate being 66 % of the patient population. It causes vertebral displacement patterns, abnormal stresses, and strain on the spinal cord. FHP has adverse mechanical tension on neural and vascular elements.

It is theorized that when muscle performance is impaired, the balance between the stabilizers on the posterior aspect of the neck and the DNFs will be disrupted, resulting in loss of proper alignment and posture, which is then likely to contribute to cervical Impairment (loss of range of motion, or decreased strength including, but not limited to, the sternocleidomastoid (SCM), trapezius, and deep neck flexor (DNF) muscles endurance of the neck musculature.

Assessment of DNF muscle performance properties is arguably important given the relationship between DNF muscle torque and endurance deficits and patient complaints of head and neck pain. sixty subjects with forward head posture assigned randomly to three groups. experimental group 1 will receive scapular stabilization plus postural correction exercise and advice, experimental group 2 will receive postural correction exercise plus advice and finally control group will receive advice.

Eligibility Criteria:
Inclusion Criteria:

1. If asymptomatic subjects with CVA equal or less than 50.
2. shoulder flexion at least 130 degrees or more, they involved in this research.

Exclusion Criteria:

1. If they had a history of cervical spine sur¬gery
2. Cervical spondylosis
3. Cervical or shoulder neurological movement disorder, Temporo-mandibular surgery, Pathologic trauma.
A Study of Some Aspects of Health in Special Youth Care

The aim of this study is to examine some aspects of health in the special youth care. In this case it concerns the mental, social and physical and sporting health of the young people in the community institution De Kempen, Campus de Hutten. To examine these aspects of health, questionnaires will be used and participants will be asked to wear a SenseWear bracelet during their PE lessons. It is a pilot study that explores and tests the way in which certain things are best investigated in this setting. It examines how the practical side of such research should be carried out. It will also be investigated which obstacles, weaknesses and errors can be encountered when conducting such an investigation.

This research is a quantitative cross-sectional study. Questionnaires will be taken from participants to measure mental, social and physical health. In addition, Sensewear bracelets will be used during the PE lessons of the participants to collect data (MET's and number of steps).

Three short questionnaires will be taken from the boys which measure the mental, social and physical health. Completing these questionnaires will take no longer than 10 minutes in total. The questionnaires will be filled in once by each participating individual at the start of the PE lesson.

During the PE class, the participants will receive a Sensewear bracelet in which the number of METs and the number of steps during the effort are measured. A distinction will also be made between the various sports during the PE lesson. Each participant will have to wear the Sensewear bracelet once during a single PE lesson.

It is an open research in which the participants are fully informed. The participants can voluntarily choose whether or not to participate in the study. The quantitative data collected from the questionnaires and Sensewear bracelets will then be used for de-finitive interpretation and decision making.

Eligibility Criteria:
Inclusion Criteria:

* For this research, data will only be collected from male participants with the age of 13 t.e.m. 18 years. These boys are in the (closed) Community institution De Kempen, Campus de Hutten.

Exclusion Criteria:

* For this research, no data will be collected from the young people on the other campus of the community institution. Campus de Markt is the open part of the community institution and the young people who live here are not the target group of the research.
Blood Donor Competence, Autonomy and Relatedness Enhancement

The purpose of this study is to determine whether enhancing blood donor competence, autonomy, and/or relatedness increases intrinsic motivation to donate and improves donor retention.

For health, safety, and economic reasons there is a critical need for novel approaches to enhance the retention of new blood donors. The current study examines an innovative, theory-driven approach to retention by promoting intrinsic motivation to donate again among new blood donors. Self-determination theory (SDT) proposes that people are more likely to persist with behaviors that are internally versus externally motivated, and considerable research supports the notion that more internalized motivation is associated with better adherence in a variety of health contexts. Similar findings have also been reported in the blood donation context where measures of the extent to which a donor identity has been internalized are positively related to both donation intention and future donation behavior. Based on prior work, the investigators propose to test a multi-component intervention designed to enhance one, two, or all three of the fundamental human needs that contribute to internal motivation according to SDT (i.e., competence, autonomy, relatedness). Using a full factorial design, first-time donors will be randomly assigned to a control condition or an intervention that addresses one, two, or all three of the fundamental needs. The primary aim is to determine whether the intervention conditions, alone and in combination, increase the likelihood of a donation attempt in the next year. The second aim is to examine intervention-specific increases in competence, autonomy, and relatedness as potential mediators of enhanced donor retention. Finally, an exploratory aim will examine an integrative model of motivation that views autonomy as a mediating influence on the more proximal, situational-level determinants of behavior (i.e., attitude, subjective norm, perceived behavioral control, and intention).

Eligibility Criteria:
Inclusion Criteria:

* First-time whole blood donor with New York Blood Center;
* Eligible to donate again;
* Willing to be randomly assigned;
* Have, or be willing to establish, an active Facebook account.

Exclusion Criteria:

* History of more than one lifetime whole blood donation (with any blood center);
* Ineligible to donate again (based on New York Blood Center donor eligibility determination);
* Unwilling to be randomly assigned;
* Unwilling to sign up for closed Facebook group, if randomly assigned.
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

The purpose of this study is to assess the long-term safety and tolerability after an intravitreal injection (a shot of medicine into the eye) of JNJ-81201887 administered in parent clinical studies.


Eligibility Criteria:
Inclusion Criteria:

* Participants who were enrolled and received treatment with JNJ-81201887 or sham in a parent clinical study (81201887MDG2001, 81201887MDG1003)
* Females (women of childbearing potential), male participants, and partners of male participants will not be required to use contraception in this LTE study
* Must sign an informed consent form (ICF) indicating that participant understands the purpose of, and procedures required for, the study and is willing to participate in the study. The ICF may be signed by an impartial witness and/or legally designated representative depending on national/local regulations

Exclusion Criteria:

* There are no exclusion criteria for this LTE study
Impact of the Assumption in Charge of Medical Aid to the Procreation With Donation of Gametes on the Sexuality of the Couple

Sexual disorders associated with medical aid for procreation have already been demonstrated in several studies. However, few of them are interested in the problem of patients in charge of donating gametes, and if studied, it is often restricted to donating sperm to a small number of patients. For this reason, it would be interesting to study the impact of the intake and in charge and the treatments of the Medical Aid to the Procreation on this population of patients (including the patients treated in donation of sperm but also Those supported in oocyte donation)


Eligibility Criteria:
Inclusion Criteria:

* Couple, male and female, meeting the legal criteria for access to medically assisted procreation: a couple, a woman under the age of 43, who can testify to a life together. Then breakdown into 3 inclusion groups:

  * Group 1: Patients undergoing AMP with oocyte donation
  * Group 2: couples supported in AMP with sperm donation
  * Group 3: torque supported in intra torque AMP.

Exclusion Criteria:

* Patients who do not meet the legal criteria for access to the MPA.
* Patients in charge of Medical Assistance for Procreation "Viral Risk"
* Patients undergoing medical aid for procreation for pre-existing sexual dysfunction.
* Patients awaiting embryo reception.
Prevention and Treatment of Stretch Marks With Stratamark™

Stretch marks (striae distensae) are a form of scarring that is a natural result of pregnancy, obesity and in some instances occur due to puberty or steroid use. For some people, the stretch marks do not cause a problem, but in many circumstances they can cause physical symptoms such as itchiness, tenderness and pain. For many people stretch marks are also embarrassing and can have detrimental effects on a patient's mood and self-esteem. Stretch marks that result from pregnancy most commonly occur on the abdomen, breasts and thighs.

Topical silicone gel was developed nearly thirty years ago to be used in the treatment of widespread hypertrophic scars (abnormal scars, which may be red or raised/depressed itchy or painful). Since this time it has been used successfully on most scar types. . Since stretch marks are a form of scarring it is thought that topical silicone gel may be helpful for this scar type also. Stratamark™ has been developed using different forms of silicone polymers, in a gel format, that dries to form a very thin and flexible silicone gel sheet making it a convenient therapy for the treatment and prevention of stretch marks.

The aim of this clinical research study is to prove or disprove the efficacy, safety and tolerability of Stratamark™ in the prevention and treatment of stretch marks. In addition, the knowledge gained from this study may be of benefit to many future patients


Eligibility Criteria:
Prevention arm - Inclusion Criteria:

* Healthy pregnant woman (nulliparous or multiparous) entering into their third trimester (26-28 weeks, visit 1)
* Not having striae on their abdomen at the time of trial enrollment

Prevention arm - Exclusion Criteria:

* Any significant medical or surgical conditions
* Current medications liable to interfere with study results or change the skin's response to therapy

Treatment arm - Inclusion Critera:

• Confirmed SD on their abdomen post-delivery

Treatment arm - Exclusion Criteria:

* Any significant medical or surgical conditions
* Current medications liable to interfere with study results or change the skin's response to therapy
Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial

RESEARCH HYPOTHESIS

-Incidence of preterm delivery is lower in women treated with oral micronized progesterone (Utrogestan) as acute tocolysis agent compare to Nifedipine group with fewer maternal side effect


Eligibility Criteria:
Inclusion Criteria:

• Singleton pregnancy women between 22 and 34 weeks of gestation who presented with threatened preterm labor.

Exclusion Criteria:

* Multiple pregnancies
* Women with Preterm Prelabour Rupture of Membrane
* Fetal death
* Women with bad obstetric history
* Women with history of cervical incompetence
* Contraindication to Nifedipine such as cardiovascular disease, hyperthyroidism, severe pre eclampsia or to Utrogestan
* Maternal or fetal indication for immediate delivery, such as fetal distress, bleeding placenta previa, abruption placenta
* Contraindication for tocolysis, for example severe pre eclampsia, intrauterine growth restriction, fetal anomaly, chorioamnionitis, significant antepartum haemorrhage
* Cervical dilatation of 3cm or more
* Patients with previous tocolytic treatment during this pregnancy
* Women who refuse to participate in this study
Major Depressive Disorder In The Elderly

This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).


Eligibility Criteria:
Inclusion Criteria:

* Primary diagnosis of Major Depressive Disorder with DSM-IV criteria for their current episode for at least 8 weeks.

Exclusion Criteria:

* Patient has current or past history of seizure disorder or brain injury.
* Patient has a diagnosis of anorexia or bulimia within the past 12 months.
* Patient has a past or current DMS-IV diagnosis of schizophrenia or any other psychotic disorder(s).
* Patient has had a myocardial infarction within 1 year or a history of uncontrolled hypertension or unstable heart disease with 6 months.
Study for a Rational Management of Appendicitis in Children

Despite the fact that appendicitis is one of the most frequent surgical pathology in children, its clinical management is still debated. Previous reports have shown rate of appendectomy in children without appendicitis up to 30 %. Morbidity, due to infectious complications or intestinal obstruction, is often between 5 and 10 % of published cases, and increase medical and social costs. Evidence-based medicine concept could therefore be worthwhile in that context, in order to promote rational diagnosis and treatment of that frequent medical condition.An algorithm describing management of children with suspicion of appendicitis was established, based on recent published data, in order to reduce delay between first clinical signs and confirmation of the diagnosis, and to define therapeutic indication such as conservative management and interval appendectomy or patient requiring laparoscopic approach. The main objective of the study is to decrease morbidity and unnecessary appendectomy rates, and secondly to decrease costs, by the use of that algorithm.


Eligibility Criteria:
Inclusion Criteria:

* male and female children, between 4 and 15 years-old, with more than 37,5°C of body temperature during the 3 days before hospital admission, and with abdominal pain located in right or median lower quadrant

Exclusion Criteria:

* children coming from another hospital, children with septic choc, children with co-morbidity in interaction with algorithm (antibiotics allergy, mellitus diabetes, haemostasis disturbance, ...)
Educational Module and Decision Counseling Program in Increasing Mammography Screening Rates in Formerly Homeless Women With Serious Mental Illness

This pilot clinical trial studies how well an educational module and decision counseling program works in increasing mammography screening rates in formerly homeless women with serious mental illness. An educational module and decision counseling program may be an effective tool and have the potential to help with early detection and treatment.

PRIMARY OBJECTIVES:

I. Increase mammography screening rates in women age 40 and over with experiences of homelessness and serious mental illness (SMI).

II. Increase knowledge, decease psychological distress, and advance decision stage and intention to get a mammogram in study participants.

Eligibility Criteria:
Inclusion Criteria:

* 30 formerly homeless women with a diagnosis of a serious mental illness in the Pathways to Housing or Project HOME supportive housing programs
* Only women that have never received a mammogram are eligible to participate (self-report)
* Participants must be willing to participate in all aspects of research

Exclusion Criteria:

* Participants cannot be decisionally impaired, actively psychotic, or have unstable mental illness that prevents participation in the decisional counseling session
* Women who have had a mammogram will be excluded from the study
Timing of Umbilical Cord Clamping in Term Cesarean Deliveries

The aim of this study is to show that delayed umbilical cord clamping or milking of the umbilical cord in pregnant women undergoing elective cesarean delivery might have better effects than early clamping, on neonatal results without causing maternal hemorrhage or negatively affecting the neonatal outcome , and to compare the superiority of these three methods to each other.

Late clamping of the umbilical cord has been shown to have positive effects such as higher neonatal hemoglobin level, higher iron stores in the newborn around three to six months, and better neurological development. In 2017, American College of Obstetricians and Gynecologists (ACOG) recommended a minimum 30-60 seconds delayed clamping of the cord after a minimum of 30-60 seconds, regardless of the delivery method, in both term and preterm newborns. In addition, optimal placental transfusion can be achieved due to strong uterine tonus in vaginal delivery. However, this is not possible due to decreased uterine tonus and time constraint in cesarean delivery. The main concern in delayed clamping and milking of the umbilical cord is the possibility of maternal anemia due to excessive maternal blood loss in the short term, the need for maternal blood transfusion or maternal intensive care support, and the possibility of conditions such as hyperbilirubinemia, symptomatic polycythemia, and long hospital stay that may cause the need for phototherapy in the newborn. Although there are many studies in the literature regarding the neonatal results of the clamping timing of the umbilical cord, there are a limited number of articles regarding the results in patients who underwent term elective cesarean section. The aim of this study is to show that delayed umbilical cord clamping or milking of the umbilical cord in pregnant women undergoing elective cesarean delivery might have better effects than early clamping, on neonatal results without causing maternal hemorrhage or negatively affecting the neonatal outcome , and to compare the superiority of these three methods to each other.

Eligibility Criteria:
Inclusion Criteria:

* \> 37 weeks uncomplicated singleton pregnancy
* Elective cesarean delivery
* Cesarean section under regional anesthesia

Exclusion Criteria:

* \< 37 weeks pregnancy
* Surgery performed under general anesthesia
* Emergent cesarean
* Multiple pregnancy
* Medically unstable mother or fetus
* Uncontrolled maternal diabetes
* Major congenital malformation of chromosomal abnormality of the fetus
* Intrauterine growth retardation
* Prenatal asphyxia suspicion
* True knot in the umbilical cord
* İn case of meconium aspiration syndrome suspicion
The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks

• The purpose of this study is to investigate which physiological process that controls normal human body homeostasis is affected by low levels of acute hypoxic exposure and whether there is a difference in those physiological processes and simulated flight performance between a rapid and ramp hypoxic exposure. To accomplish this, pilot analogs will be exposed to normoxic, simulated 8,000 ft (2438 m), simulated 12,000 ft (3658 m), and a ramp exposure breathing at simulated 8,000 ft for 5 minutes before ascending to simulated 12,000 ft while flying in a flight simulator. During the flight simulator, participants will need to accomplish three tasks: 1) Maintaining an altitude of 5,000 ft of elevation while performing a mental math test, 2) Flying the aircraft through the center of a series of 7 targets, and 3) Taking off and flying the aircraft a short distance to land on the center of an indicated target. Physiological measures of heart rate variability (HRV), blood pressure (BP), peripheral oxygen saturation (SpO2), electrodermal activity (EDA), and neck neuromuscular activity using electromyography (EMG) will be measured for this study. Along with questionnaires to assess hypoxic symptoms, simulator sickness, and self-perceived workload for each task


Eligibility Criteria:
Inclusion Criteria:

* Meets body composition standards for the US Navy Active-duty personnel based on height and weight
* Normal vision/corrected to normal vision

Exclusion Criteria:

* Respiratory Deficiencies
* Cardiovascular Disorders
* Neurological/Musculoskeletal Disorders
* Photosensitive Epilepsy
Migalastat Food Effect Study

A 5-period crossover study to evaluate the effect of meal type and timing on migalastat HCl pharmacokinetics in healthy male and female subjects. Subjects will be randomly assigned to 1 of 5 treatment sequences and will receive each treatment over the course of 5 weekly periods.

This is a Phase 1, randomized, open-label, 5-period crossover study to evaluate the effect of meal type and timing on migalastat HCl pharmacokinetics in healthy male and female subjects between the ages of 18 and 65 years. A total of 20 subjects will be enrolled such that approximately 14 evaluable subjects complete dosing and critical assessments. Subjects will be randomly assigned to 1 of 5 treatment sequences and will receive each treatment over the course of 5 successive weekly periods including a single dose of migalastat HCl 150 mg in the fasting state as the reference treatment. There will be at least a 7-day washout period between each dose of migalastat HCl and a follow-up visit approximately 7 to 10 days after the last dose in Period 5.

All subjects will be screened within 28 days of admission to the clinical unit. In each period, subjects will check in to the clinical unit the day prior to drug administration and have relevant assessments to ensure continued eligibility for dose administration. On Day 1 of each period, subjects will receive a single dose of migalastat HCl within 1 of the following 5 treatment regimens as follows:

* 150 mg migalastat HCl in the fasting state (reference arm)
* 150 mg migalastat HCl with simultaneous consumption of a glucose drink
* 150 mg migalastat HCl 1 hour before consumption of a high fat meal
* 150 mg migalastat HCl 1 hour before consumption of a light meal
* 150 mg migalastat HCl 1 hour after consumption of a light meal

Subjects will be confined to the clinical unit for 24 hours after dosing with serial blood samples collected for PK analysis. Safety will be assessed throughout the study by monitoring clinical laboratory tests, ECGs, physical examinations, vital signs, and AEs.

Eligibility Criteria:
Inclusion Criteria:

* Male or Female aged 18 to 65 years inclusive
* Healthy, as determined by study physician
* Capable of giving informed consent

Exclusion Criteria:

* Positive for HIV or Hepatitis B and/or C viruses
* History of drug or alcohol abuse or addiction within 2 years
* Smoker or consumes tobacco products
* Participation in a clinical trial within 30 days of scheduled first dose