cyrilzakka/clinical-trials huggingface dataset:
Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program

The goal of this quality improvement program is to implement, evaluate, and sustain an evidence-based smoking cessation treatment program with a population-based approach so that all patients at the Siteman Cancer Center, Washington University, Barnes-Jewish Hospital, BJC Healthcare, and satellite locations receive assessment of smoking and all smokers receive treatment support.


Eligibility Criteria:
Inclusion Criteria:

-Patients seen at Siteman Cancer Center, Washington University, Barnes-Jewish Hospital, BJC Healthcare, or any of the satellite locations

Exclusion Criteria:

-None
Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children: a Randomised, Double-blind, Placebo-controlled Study

Viral upper respiratory tract infection (URI) is one of the most common diseases among toddlers and pre-school children.Complete and effective prevention measures for URI are currently unavailable.

Montelukast (Singulair ) is a selective leukotriene-receptor antagonist that inhibits the cysteinyl leukotriene 1 receptor. It is well tolerated and safe even in young children. Montelukast is an effective treatment for asthma (and allergic rhinitis from 1 year of age. Infections with viruses causing URI such as Influenza A, Rhinovirus and respiratory syncitial virus increases leukotriens levels in nasal secretions. Therefore, one may postulate that leukotriens inhibitors may reduce symptoms during URI. However the effect of montelukast as a treatment for non-specific cough was not properly studied and there are no studies on the effect of montelukast as prevention for URI.

Hypothesis: Prophylactic treatment with Montelukast will reduce the incidence and severity of upper respiratory infection in children.


Eligibility Criteria:
Inclusion Criteria:

* Children 1 to 5 years old without significant health problem.

Exclusion Criteria:

* A previous history of wheezing (requiring treatment with bronchodilators in the last 3 month or more than one treatment in the last year)
* Hospital admission due to reactive air way disease
* Prophylactic use of montelukast or steroids
* Chronic cardiac or respiratory disease
* Presence of acute respiratory tract infection within the 7 days before consideration for the study
* History of allergic Rhinitis
* Children who are receiving chronic medications of any kind
* Known allergy to montelukast
* Inability to get an informed consent from a legal guardian.
Assessment of a B-Mode Ultrasound Technique for the Measurement of Carotid Artery Intima-Media Thickness

This minimal risk protocol is designed to assess the reproducibility of B-mode ultrasound measurements of carotid intima media thickness (IMT) when the scans are performed in CC Radiology and read using a computerized edge reader. Up to 20 volunteers will have two ultrasounds performed within a 6-month period. IMT thickness is used as a surrogate marker for atherosclerosis and may be of value in clinical trials.

This minimal risk protocol is designed to assess the reproducibility of B-mode ultrasound measurements of carotid intima-media thickness (IMT) when the scans are performed in CC Radiology and read using a computerized edge reader. Up to 50 volunteers will have two ultrasounds performed within a 6-month period. IMT thickness is used as a surrogate marker for atherosclerosis and may be of value in clinical trials.

Eligibility Criteria:
Adult (age 18 or older).

Desire to participate in the study; willing and able to provide informed consent.

No history of stroke or carotid disease.
Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

10 healthy male volunteers will be studied after

* a 6 day weight maintenance, balanced diet
* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day
* a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained
* intrahepatic lipids (1H-MRS)
* metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study


Eligibility Criteria:
Inclusion Criteria:

* age 18-30 years
* sex: males
* BMI between 19 and 25 kg/m2
* less than 3 30min- exercise session/week

Exclusion Criteria:

* smokers
* alcohol consumption more than 50g/week
* consumption of drugs
* history of diabetes in first degree relatives
* presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR
Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire

This study is designed as an observational study to collect Cardiospire cardiogenic oscillation signal (COS) and CO output parameters from the Pulmonary Artery Catheter in intubated patients.

Respirix has developed a non-invasive hemodynamic monitoring device called the Cardiospire. The Cardiospire detects minor, cyclic waveforms caused by Cardiogenic Oscillations (COS) and uses features of the COS waveform to provide information about hemodynamics.

This study is designed as an observational study to collect paired readings of the Cardiospire cardiogenic oscillation signal (COS) and the ground truth CO output parameters, including Pulmonary Artery Pressure diastolic (PAPd), systolic (PAPs), Stroke Volume (SV), and Cardiac Output (CO) from the Pulmonary Artery Catheter in intubated patients.

Eligibility Criteria:
Inclusion Criteria:

* ≥ 18 years of age
* Intubated
* Pulmonary artery catheter
* Patient or patient's legally authorized representative is able to provide informed consent

Exclusion Criteria:

* Subjects who, at the principal investigator's determination, would not be appropriate for this study
Effects of Voodoo Flossing on Ankle in Participants with Limited Ankle Dorsiflexion

In the case of normal walking patterns, the angle of plantarflexion (PF) at heel contact should be 0 to 5 degrees, the angle of dorsiflexion (DF) in the terminal stance should be 10 degrees, and the angle of PF should be 15-20 degrees when the heel off. A therapist can apply a voodoo flossing to enhance range of motion (ROM), pain control, jumping performance, strength, myofascial release, and recovery from fatigue. This study compared the immediate effects of voodoo flossing application on ankle ROM, balance, and gait ability in stroke patients. Outcome measures were ankle ROM, weight bearing lunge test (WBLT) performance, static balance (one leg test), dynamic balance(Y-balance test) and gait ability. Outcome measures were assessed at baseline and immediately after applying the voodoo flossing.

The voodoo flossing intervention used the standard voodoo flossing, wrapping a voodoo flossing (lime green Sanctband Comprefloss™, 2" × 3.5 m; PENTEL, Shah Alam, Malaysia) made of natural rubber tightly around the ankle on the affected side. It was started at the fifth metatarsal and wrapped horizontally around the metatarsals twice, in a figure eight to the medial malleolus, over the Achilles tendon and the lateral malleolus three times, and around the medial malleolus again, before being passed twice from the medial mal-leolus over the Achilles tendon to the lateral malleolus, forming an end knot. The participants were instructed to perform low-intensity active exercise involving ankle DF and plantar flexion for 2 minutes after applying the floss band. Then, the floss band was removed and the patient was asked to walk lightly on level ground for about 1 minute to allow reperfusion to normalize blood flow.

Eligibility Criteria:
Inclusion Criteria:

* less than 10° of dorsiflexion

Exclusion Criteria:

* lower extremity orthopedic problems
* unstable steps and balance
* visual impairments
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries Developmental Follow Up

An extension of the CORDMILK trial, the CORDMILK follow-up trial will evaluate the neurodevelopmental outcomes at 22-26 months age of term/late preterm infants who were non-vigorous at birth and received umbilical cord milking (UCM) or early cord clamping (ECC).

The CORDMILK Follow-up trial will examine the difference in survival and neurodevelopmental impairment of infants who were non-vigorous at birth and enrolled in the CORDMILK trial. The difference in survival and neurodevelopmental impairment in infants who received UCM and ECC will be assessed using standardized neurological and developmental assessment tools at 22-26 months of age.

Eligibility Criteria:
Inclusion Criteria:

* Enrolled in CORDMILK trial
* Non-vigorous at birth

Exclusion Criteria:

* None
Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.

The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence. Life in a small community is very different and above all unique, which could be an asset in a research setting.

To ensure its functioning, the brain needs a lot of energy. However, during aging, it has difficulty properly using its main fuel, sugar. The brain then becomes "starved". This energy deficit is part of the vicious circle leading to memory problems. The brain, like a hybrid car, can run on two fuels, sugar and ketones. Providing alternative fuel to the brain, in the form of ketones, and thus offsetting the energy it needs, could improve its functioning and help prevent or improve memory problems.

There are several ways to increase ketones in our body such as certain dietary oils, natural health products, physical activity or certain diets. Reducing the amount of sugar in our diet is also a strategy that can increase ketones. A low-sugar diet is already widely used in the prevention of several important diseases, including type 2 diabetes and even Alzheimer's disease.

This study will assess the feasibility of a community intervention project in a seniors' residence with the eventual overall objective of slowing the progression or onset of AD and related health indicators, through a dietary modification.

This feasibility study will last 6 months. The basic characteristics of interested participants will be collected. The global spheres of evaluation are the following: metabolic profile, cognition, quality of life and nutritional status. Glucose measurements will be taken continuously via a sensor over two weeks during the project.

Eligibility Criteria:
Inclusion Criteria:

* Older men or women resident of Grace Village and resident of Vü;
* Understand, read and write French or English;
* Possess sufficient visual and auditory acuity to pass the cognitive tests.

Exclusion Criteria:

* The minimum possible criteria ensuring the safety of voluntary participants. The family doctor will need to confirm eligibility.
* Body mass index \< 22
* Malnutrition.
* High risk of hypoglycaemia
* Moderate to severe digestive diseases that can be aggravated by dietary changes
* Severe dysphagia
* Supplementation with MCT oil, ketone salts, ketone ester, adherence to the ketogenic diet, intermittent fasting, or other diet or supplements that may significantly increase ketones;
* Participation in other intervention research projects on nutrition or aimed at metabolic change simultaneously.
Experiences of Pain in Healthy Adults

The experiment aims to investigate the experience of pain in healthy adults and includes a total of 60 participants. Pain is a subjective experience that has a complicated neurological and psychological basis. Around 20% of the Danish population suffers from persistent pain, which has both personal and societal consequences. Personal consequences include, among others, reduced quality of life, loss of social life and risk of anxiety and depression. However, more knowledge is needed about which mechanisms are involved in the experience of pain, so that the treatment of patients with pain can be improved.

In the experiment, healthy participants will be inflicted with a tolerable pain on their forearm using a thermode. The application of heat causes pain for a short, limited period, but it is tolerable and without risks. During the experiment, the participants will be exposed to heat several times, with and without a cream on their forearm. It is a cream that has previously proved to have pain-relieving effects on participants in similar experiments. Participants will be asked about how they experience the intensity of the pain on a scale of 1-10 (0 = no pain and 10 = worst imaginable pain), and what they expect the pain intensity will be, also on a 1-10 scale. The participants are allowed to pause or stop the experiment anytime.

The experiment contributes to insights into pain and the mechanisms involved. This knowledge can in the future contribute with knowledge to improve the treatment of patients with pain. For the individual participant, the trial will contribute with knowledge about how they experience and assess pain themselves.


Eligibility Criteria:
Inclusion Criteria:

* Normal health, i.e. no known acute or chronic illness
* Fluid in Danish

Exclusion Criteria:

* Chronic pain condition
* Other medical or psychiatric disorder
* Use of antidepressants
* Daily use of painkillers
* Use of pain medication 24 hours prior to testing
* Drug abuse
* Pregnancy
* Studying or with completed education in psychology or journalism
Comparison of CXR and MnDCT

A comparison of chest x-ray (CXR) and Minimum dose CT (MnDCT) in the acutely ill patient. The hypothesis is that MnDCT is more sensitive than CXR in the detection of acute findings in the acutely ill patient.

A comparison of chest x-ray (CXR) and Minimum dose CT (MnDCT) in a cohort of 100 patients admitted for acute respiratory distress. Chest radiography (CXR) is compared to Minimum Dose CT (MnDCT) for the detection of consolidation;lung nodules, heart failure.

Eligibility Criteria:
Inclusion Criteria:

* All patients admitted for investigation of acute pulmonary embolus

Exclusion Criteria:

* none
Group Exercise After Hip Replacement Surgery

The purpose of this study is to determine which group exercise one should choose when hip osteoarthritis patients have undergone hip replacement surgery. To determine this, we want to answer the following research question:

Are there differences in function and muscle strength in osteoarthritis patients who conduct group training either on land or in water in the rehabilitation phase following hip replacement surgery?


Eligibility Criteria:
Inclusion Criteria:

* Hip osteoarthritis patients who undergo surgery with total prosthesis at St. Olav's Hospital, Department Orkdal.
* Participants must live in commuting distance from the hospital, as the training is organized as outpatient training
* Participants must be able to take instruction and master the Norwegian language

Exclusion Criteria:

* Patients who experience serious complications after surgery
* if a person has a disease that causes that one can not complete the planned training
Prognostic Values of Next Generation Sequencing (NGS) in Acute Myeloid Leukemia Patients With Allo-HSCT

Acute myeloid leukemia (AML) is a genetically heterogeneous disease and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for AML except for AML-M3. Relapse remains the major cause of treatment failure after allo-HSCT. Molecular residual disease has been shown to be a strong risk factor for relapse after HSCT. In this study, the investigators will detect mutations before/after allo-HSCT by using next-generation sequencing (NGS) technique to measure residual disease and evaluate the prognostic impact of molecular residual disease in a cohort of AML participants receiving allo-HSCT.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or old;
* Clinical diagnosis of acute myeloid leukemia (AML);
* Availabe records of MICM and NGS results at diagnosis;
* Be going to receive allo-HSCT.

Exclusion Criteria:

* Active malignancy;
* Pregnant or breast feeding women.
Value of Manual Therapy Specificity Referred to Pain Intensity in Patients With Subacute and Unspecified Low Back Pain

This study proves the specificity of manual therapy in unspecified an subacute low back pain

The purpose of the study is to determine the importance of manual therapy specificity in relation to subacute low back pain.

In order to do this, it will be selected a sample of at least 48 people who suffer low back pain whose duration has not exceeded 12 weeks. Patients will be divided into two groups and a different physiotherapist from the one who will subsequently perform the intervention, will assess and determine which is the most painful segment in each of them.

In the first group, the intervention to be carried out will be through posteroanterior (PA) vertebral mobilizations in the most painful lumbar segment. The members of the second group will undergo this same technique on a painful segment of the region adjacent to the one they have referred as the main source of pain.

Each of these sessions will continue until the patient's symptoms have decreased two points on the numerical scale of pain. There will be one session per week, for six weeks.

To determine the differences between the two groups, there will be carried out 4 measurements of pain, functional disability, quality of life and kinesiophobia, and 3 measurements of pressure pain threshold were performed. Each one of them will be carried out in the first session, in the third week of treatment, in the last session of the treatment and one month after the end of the treatment. The last measeurement will be executed online and that is why the pressure pain threshold will be measured three times while the rest will be do it.

The hypothesis is that it won´t be differences in the amount of pain between the tratment on the main painful segment and the treatment on his adyacent segment.

Eligibility Criteria:
Inclusion Criteria:

* People aged between 18 and 65 years old with unspecific and subacute low back pain.
* Participants must be capable of walking twice a week 20 minutes per day.

Exclusion Criteria:

* People with history of spinal surgeries, osteoporosis and tumor.
* Pregnant and people with severe respiratory and cardiac illness.
Acute and Long-term Outcomes of Patients With Acute Myocardial Infarction Treated With PCI

Randomized studies may often be burdened by the selective nature of patient inclusion thus not reflecting real-world outcomes. This is evident from the discrepancy in the mortality rates reported in major randomized trials enrolling patients with acute myocardial infarction (AMI), as compared with registry data.

The primary objective of this observational study is to assess short- and long-term outcomes of unselected, real-world patients presenting with AMI and treated with contemporary percutaneous coronary intervention (PCI).


Eligibility Criteria:
Inclusion Criteria:

* Patients with acute myocardial infarction referred to catheterization laboratory for percutaneous coronary intervention

Exclusion Criteria:

* Initial acute myocardial infarction diagnosis not confirmed
* Patients with acute myocardial infarction not undergoing invasive coronary angiography
Efficacy of Piroxicam as a Perioperative Analgesic for Patients Undergoing Fixation of Maxillofacial Fractures

At Eldemerdash Hospital at Ain Shams University in Egypt, 72 adult patients (16 to 25 years old) who had mandibular or maxillary fractures were treated with open reduction and internal stabilization. Patients were divided into two categories. (31 patients each) Using randomly generated data from computer, the piroxicam group received 0.4 mg/kg of intramuscular piroxicam, while the general anesthesia group (GA group) did not receive piroxicam.

The overall amount of rescue analgesic dosage and postoperative complications like nausea and vomiting were therefore included in the outcomes measurement.

Patients were divided into two groups at random using a computer-generated list: the GA group received no piroxicam and the piroxicam group got a 0.4 mg/kg IM piroxicam induction. Both groups got IV paracetamol (24 mg/kg slowly administered over 20 minutes).

Fentanyl 2 micrograms/kg was administered after general anesthesia was induced and venous access was established. A suitable size endotracheal tube was then placed intranasal, and intubation was aided by Atracurium (0.5 mg/kg). Throughout the operation, 1 MAC isoflurane in a mixture of 50% air and oxygen was used to maintain anesthesia in all patients who were mechanically ventilated in pressure-controlled mode with targeted EtCO2 (30-35 mmHg). An oral pack was also introduced.

After the operation general anesthesia was stopped and the endotracheal tube was removed, Neostigmine 50 mg/kg and atropine sulfate 15 mg/kg were used to reverse muscle relaxation. Patient transportation was made to the post-anesthesia care unit (PACU). Postoperative analgesia was evaluated by a blind investigator using 10 cm- visual analogue scale score which had been explained to the patient on the preoperative visit where: 0 = no pain, 10 = worst possible pain) in the PACU then at 3, 6, 12, 24 hours, if the pain score \>3, pethidine 25 mg intravenously and Ondansetron 0.1mg/kg was used for cases with nausea or vomiting.

Eligibility Criteria:
Inclusion Criteria:

* patients aged from 16-25 years old
* ASAI II
* scheduled for open reduction and internal fixation of mandibular or maxillary fractures

Exclusion Criteria:

* a history of convulsion,
* gastrodudenal ulcer
* hematological disorders
* patient suffering from hepatic or renal dysfunction
* concomitant use of anticoagulants
* refusal of the patients to participate
* patients younger than 12 years