cyrilzakka/clinical-trials huggingface dataset:
Comparison of the Effectiveness of EMG-Biofeedback and Rebound Therapy in Patients With Endometriosis

The aim of our study is to investigate the effects of pelvic floor muscle strengthening exercises with EMG-Biofeedback and pelvic floor muscle strengthening exercises with Rebound therapy on pelvic floor muscle strength, pain level, NGF level, perceived stress level, quality of life and sleep in women diagnosed with endometriosis.

Endometriosis is a chronic, systematic, inflammatory, estrogen-dependent public health problem characterized by the growth of endometrial-like tissue outside the uterine cavity, including the pelvic peritoneum, rectovaginal septum and ovaries, and is particularly seen in women of reproductive age and significantly affects quality of life. The aim of our study is to investigate the effects of pelvic floor muscle strengthening exercises with EMG-Biofeedback and pelvic floor muscle strengthening exercises with Rebound therapy on pelvic floor muscle strength, pain level, NGF level, perceived stress level, quality of life and sleep in women diagnosed with endometriosis. The study will consist of 3 groups. Group 1: EMG-Biofeedback group, Group 2: Rebound Therapy Group and Group 3: Home Exercises Group. Participants will be included in the study for 8 weeks. During the evaluation, pelvic floor muscle strength will be assessed with EMG, pain level with Visual Analog Scale (VAS), perceived stress level with Perceived Stress Scale, quality of life with Endometriosis Health Profile Questionnaire (EHP-30), and sleep quality with Pittsburgh Sleep Quality Index (PSQI). NGF analysis will be evaluated by analyzing serum samples of patients with ELISA kit. Evaluations will be made before and after treatment.

Eligibility Criteria:
Inclusion Criteria:

* Being between 20-50 years old,
* Being diagnosed with endometriosis,
* Completing the voluntary consent form,
* Pain level being at least 4 on the Visual Analog Scale (VAS).

Exclusion Criteria:

Exclusion Criteria for the EMG-Biofeedback Group:

* Being included in another study during the study period,
* Being receiving medical treatment for endometriosis,
* Presence of gynecological bleeding,
* Presence of communication and cooperation problems,
* Presence of tubo-ovarian abscess,
* Active vaginal or urinary tract infection,
* Pregnancy and giving birth within the last 12 months,
* Presence of impaired somatosensory status,
* Not attending 2 consecutive sessions.

Exclusion Criteria for the Rebound Therapy Group:

In addition to the exclusion criteria determined for the EMG-Biofeedback Group;

* Presence of a neurological or orthopedic disease affecting the lower extremity,
* History of spine and/or lower extremity orthopedic surgery,
* Presence of severe arthritis affecting the spine and/or lower extremity,
* Presence of uncontrolled hypertension and cardiovascular disease.
Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application

This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.

The main questions the study aims to answer are:

* What is the most effective pre-GLIM screening approach?
* Which of the simple, globally accessible muscle mass measurement methods works the best in the context of GLIM?
* How does using simpler approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition and 1-year mortality?

Participants will be/have:

* asked questions about their recent food intake and possible non-volitional weight loss
* assessed for malnutrition with SGA
* weighed, and their height will be measured (if not already recorded)
* their muscle mass measured with a measuring tape (mid-upper arm circumference and calf circumference) and bioelectrical impedance
* their muscle function measured using hand grip strength
* have their patient records looked at to extract their weight and height data (if present), diagnoses, routine blood test results, abdominal computed tomography (CT) scan (if present), dual-energy x-ray absorptiometry (DEXA) scan (if present), 1-year mortality and personal identification code for documentation (the latter will be deleted when the study period is over).

Eligibility Criteria:
Inclusion Criteria:

* Age of 18+ years
* Able and willing to sign the consent form
* Inpatients of the Tartu University Hospital
* Admitted within 72 hours before enrolment

Exclusion Criteria:

* Age of \<18 years
* Inability or refusal to sign the consent form
* Pregnant or lactating women
* More than 72 hours passed since admission
* Patients isolating with an infection
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19

Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6 months. Recently, platelet-rich plasma (PRP) was used in patients with non-COVID-19 COD and authors reported encouraging results. In the present study, the investigators investigated the usefulness and safety of PRP injection in 56 patients with COVID-19 COD.

Our results showed that PRP in the olfactory cleft can increase the olfactory threshold one month after the injection. Moreover, our results suggest that timing of treatment may be an important factor and that PRP is a safe treatment because no adverse effects were reported throughout the study


Eligibility Criteria:
Inclusion Criteria:

* Patient chronic olfactory dysfunction lasting more than 6 months after an infection of COVID-19

Exclusion Criteria:

* Patient under 18 years old
* Patient with blood disorder
* Blood thinner user
* Patient with abnormal findings on nasal endoscopy (e.g., polyposis, rhinosinusitis)
Targeted Metabolomics to Decipher Dietary Contributions to Pediatric Inflammatory Bowel Disease (IBD) - Main Study

The overall goal of the study is to investigate the dietary differences between children with well-controlled inflammatory bowel disease (IBD) and those with active disease by using targeted food metabolomics. The utilization of the application of targeted metabolomics allows for the investigation of specific components of foods and their effects in IBD and inflammation, which may inform future dietary recommendations for IBD patients.

The investigators overall hypothesis is that higher intake of animal origin foods lead to higher concentrations of TMAO and its precursors (TMA, choline and carnitine), which causes gut microbiota dysbiosis, ultimately resulting in elevated inflammatory markers (systemic and/or fecal) in pediatric inflammatory bowel disease (IBD).

The two primary aims include:

Aim 1: Examine the relationship between IBD activity, dietary patterns, and diet-derived potential biomarkers in serum and urine.

Aim 2: Investigate the association between IBD activity, dietary patterns, gut microbiome, and diet-derived potential biomarkers in stool.

Investigators will also explore the integrated relationship between disease activity, diet, gut microbiome, diet-derived potential biomarkers, and inflammatory markers.

Investigators will recruit 100 subjects with known IBD of \> 6 months duration. Subjects will be asked to complete dietary questionnaires, and provide stool, urine, and blood samples.

Eligibility Criteria:
Inclusion Criteria:

* Male and Female
* Established IBD diagnosis (both well-controlled and active disease) for \> 6 months
* Followed by the Children's Hospital Colorado (CHCO) IBD Center
* Ages 8-18 years

Exclusion Criteria:

* Vegan diet
* Exclusive enteral nutrition (EEN) currently or within 2 weeks of enrollment
* History of full colectomy
* Ongoing active gastrointestinal infection
* Severe malnutrition (BMI less than 5th percentile)
* Presence of ostomy
* Recent medication changes
Mental Health in Primary Care

The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary care clinics in the South Florida area.


Eligibility Criteria:
Inclusion Criteria:

1. Female and male adolescents, who self-identify as Hispanic (or Latino(a))
2. Adolescent between the ages of 12 - 16 years
3. Adolescent living with an adult primary caregiver who is willing to participate
4. Families must have broadband internet access on a device, including (but not limited to) a smartphone, iPad, tablet, computer at their home or other location (e.g., school, library, etc.)
5. Families screening positive on poor family communication (a score of less than 75 on the communication measure; see measures) or youth reporting elevated depressive or anxiety symptom scores (defined as 70 to 90 on the K-CAT) or a history of suicide behavior (ideation or attempts).

Exclusion Criteria:

* Families reporting plans to move out of the South Florida area during the study period.
Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes

Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life. Subtle changes in white matter predict cognitive changes in these patients but how this disrupts brain function remains unclear. Development of effective therapeutics to restore normal cognition hinges on elucidating these functional changes. The investigators seek to uncover the patho-physiological basis for cognitive decline in MS. The investigators hypothesize that cognitive decline originates from disrupted gamma oscillations and that gamma oscillations are disrupted by molecular changes triggered by demyelination.


Eligibility Criteria:
Inclusion Criteria (\*applicable to controls):

1. Must be between 6 and 17 years and 11 months of age\*;
2. Have a diagnosis of MS according to the revised McDonald diagnostic criteria and/or International Pediatric MS Study Group criteria;
3. Has English language knowledge at the level needed to complete clinical questionnaires (4th grade level).\*

Exclusion Criteria (\*applicable to controls):

1. Neurological comorbidity.\*;
2. Relapses or requires treatment with steroids within 30 days from enrollment;
3. Is pregnant at the time of enrollment.\*;
4. Has any metal parts in their body (i.e. Cochlear (ear) implant, metal braces (dental fillings are o.k.).\*;
5. Is younger than 6 years of age.\*;
6. Is older than 18 years of age.\*;
7. Has prior history of traumatic brain injury, neurological disorder, cerebral palsy, developmental delay or learning disability.\*;
8. Requires sedation for brain scanning.\*;
9. Is claustrophobic, as brain scanning requires children to enter a tunnel in the MRI machine.\*
Intravesical Chemotherapy Treatment of Superficial Bladder Cancer

This is a phase II study where chemotherapy (gemcitabine) is given into the urinary bladder.


Eligibility Criteria:
Inclusion Criteria:

* Superficial bladder cancer
* No prior chemotherapy

Exclusion Criteria:

* Grade 3 tumors
* Papillary tumors invading connective tissue
* Significant urologic disease, possible interfering with intravesical therapy
ED Decision Making Among Hypotensive Patients

The goal of this study is to assess decision making skills of emergency physicians when dealing with hypotensive patients. The hypothesis is that decisions made based on physical exam and vital signs regarding fluid resuscitation by emergency physicians are not statistically equivalent to those that would be made based on the use of a non-invasive CVP measurement

If physicians can make appropriate decisions about the need for fluid resuscitation without CVP measurement, then this skill is worth being passed to physicians in training. Previously it was not possible gather enough information about the response of patients' because of the risk of using indwelling CVP sensors. But now because there is a low risk tool (Venus 1000 System), this study is now practical and safe.

Eligibility Criteria:
Inclusion Criteria:

* All patients \>=18 years of age who enter the Emergency Department at Hahnemann Hospital with Systolic Blood pressure \< 100 mm Hg

Exclusion Criteria:

* Those patients who are suffering from traumatic injury requiring Level I or Level II trauma evaluations. Example conditions include penetrating injuries to head, torso and proximal extremities.
* Additional exclusion criteria include the presence of an internal jugular or a subclavian central venous line or both external jugular veins being cannulated (attempted or successful) with peripheral IVs.
* Pregnant females will be excluded.
* Subjects under the age of 18 years will be excluded
Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy

The prevalence of valvular heart disease is on the rise along with the aging society and the generalization of echocardiography. Furthermore, the rheumatic valvular heart disease is much more prevalent in Asia than in Western countries, and the frequency of valve disease is higher in Asia. The effect of an implantable cardioverter defibrillator (ICD) in the primary prevention of sudden cardiac death in ischemic cardiomyopathy is well established and has become a standard of care. However, there is limited research on the effect of ICD implantation for primary prevention in patients with heart failure due to valvular heart disease. In a small study, the incidence of fatal cardiac arrhythmia was lower in patients with valvular cardiomyopathy (5%) who received ICD implantation for primary prevention than in those with ischemic cardiomyopathy. But there is also a report that the appropriate ICD treatment is not different from that of ischemic heart disease in valvular heart disease patients. Therefore, it is necessary to study the primary prevention effect of ICD on valvular cardiomyopathy in a larger number of patients. The purpose of this study was to investigate the effect of ICD on the prevention of sudden cardiac death in patients with heart failure due to valvular heart disease through prospective, multicenter, and observational studies.


Eligibility Criteria:
Inclusion Criteria:

* Patients who meet one of the following criteria:

  * Patients who have undergone surgery for aortic valve or mitral valve disease for more than 12 months
  * Patients with severe aortic valve or mitral valve disease
* Patients with left ventricular ejection fraction ≤ 35% by echocardiography or other imaging methods
* US, European practice guidelines class I indication for ICD implantation
* Patients without evidence of ischemic heart disease (who meet one of the following criteria):

  * Stress test negative
  * Significant stenosis was not observed in coronary artery images:

epicardial coronary stenosis \<70%, left main stenosis \<50%

* History of heart failure symptoms
* Patients who have received medication for more than 3 months according to the heart failure treatment guideline recommendation

Exclusion Criteria:

* Patients with left ventricular dysfunction without valvular heart disease
* Patients who require cardiac pacing therapy due to bradycardia
* Heart transplant scheduled
* Life expectancy is less than one year
Testing the Efficacy of Pokemon Go for Increasing Physical Activity

Historically, increasing activity was synonymous with exercise; however, it is now thought that even much more modest activity levels (e.g., simply walking) or merely decreasing the proportion of sedentary time may be sufficient to decrease future morbidity and mortality. Some interventions designed to increase activity have shown promise; others have been less successful. But even promising interventions are often difficult to generalize to real-life clinical settings. One barrier to monitoring the effectiveness of interventions has been the lack of availability of accurate, reliable and inexpensive personal activity monitoring equipment. The availability of inexpensive pedometers, and, more recently, low cost triaxial accelerometers, has now made it much easier to monitor activity levels and provide feedback to users. These devices are ideal for capturing activity associated with walking, the most popular and acceptable form of exercise, but only if patients actually wear them. Thus, there is a need to develop pragmatic approaches that encourage patients to not only wear these monitoring devices, but also motivate them to increase their activity.

In recent years, games have been used in a variety of settings to motivate and change behavior. Games not only provide performance feedback to patients, but also provide incentives for achieving goals in a context that is fun, intrinsically rewarding, and easy to understand. Successful games effectively exploit motivating social factors (e.g., competition, peer support, and entertainment) to maintain interest and engage participants. Steps are counted using a commercially available triaxial accelerometer (e.g., a FitBit). Pokemon Go is an augmented reality game that encourages players to go outside to search for Pokemon creatures.


Eligibility Criteria:
Inclusion Criteria:

* 18-80 years of age, healthy adults, own smart phone, have access to the Internet, fluent in English, no contraindications to physical activity, not pregnant or planning to become pregnant, had not previously played Pokemon Go game

Exclusion Criteria:

* \<18 year or older than 80 years of age, did not own smart phone, did not have access to the Internet, not fluent in English, any contraindications to physical activity, pregnant or planning to become pregnant in next 2 months, had previously played Pokemon Go game
Blood Donor Recruitment During Epidemic of COVID-19

In December 2019, an unknown pneumonia rapidly spread in Wuhan, China, a new coronavirus, 2019 novel coronavirus (2019-nCoV), aroused the attention of the entire world. On January 31, 2020, World Health Organization (WHO) announced the outbreak of Coronavirus Disease 2019 (COVID-19) in China as a Public Health Emergency of International Concern. The number of volunteer non-remunerated blood donors decreased because of quarantine, caring for relatives, and fear of exposure to COVID-19. Due to the blood shortage, patient blood management and cessation of elective surgery are contributing to decreased demand, but sepsis may increase requirements and significant reductions will not be possible in areas such as trauma, cancer patients, hereditary haemolytic anaemias and childbirth. Therefore, recruiting enough blood donors during the epidemic is vital for public health in China, and also worldwide. In order to assess the effects of a questionnaire on blood donor recruitment, the investigators designed two kinds of self-administered, standardized and structured questionnaires. In addition of the basic socio-demographic characteristics, one questionnaire includes the information of precautions of blood donation during epidemic, and the other dose not. The questionnaires were randomly sent to ever blood donors, and the same number of ever blood donors are coded as control.

In order to assess the effects of a questionnaire on blood donor recruitment, the investigators designed two kinds of self-administered, standardized and structured questionnaires. In addition of the basic socio-demographic characteristics, one questionnaire includes the information of precautions of blood donation during epidemic, and the other dose not.

Information of precautions of blood donation during epidemic included taking donor's temperature and enhancing hand disinfection before donation etc.

The questionnaires were randomly sent to ever blood donors, and at the same day, equal number of ever blood donors as the ones who filled the questionnaire are coded as control.

Eligibility Criteria:
Inclusion Criteria:

* Blood donors whose last donation were between 1 Feb to 31 March, 2019.

Exclusion Criteria:

* Blood donors whose blood test results were positive. Blood donors who were aged above 60. Blood donors whose cell phone number was obviously invalid.
To Survive After ICU Discharge

Many factors before and after ICU stay determine the outcome of patients at ICU discharge, the type of illness, physical dependence and other sequelae can be a trigger for complications in hospital ward which can induce ICU readmission and worse outcome. The quality of medical assistance during all the hospitalisation should be guaranteed and many complications or fatal events could be avoidable.

The objective of the present study is to demonstrate that collaboration between the intensivist and other medical teams in ward can reduce ICU readmission and hospital mortality after ICU discharge.

Material and Methods This observational multicenter study will be done in 21 medical-surgical ICUs. We will use Sabadell Score like prognostic scale at ICU discharge and the intensivist will collaborate with the medical team in medical assistance of patients at risk (Sabadell Score 1 and 2). Investigators will compare the hospital mortality and the readmission rate with a previous period when this collaboration didn't exist.

Anticipate results The collaboration of attending intensivist might reduce ward mortality after ICU discharge by 3%.

Eligibility Criteria:
Inclusion Criteria:

* All patients with Sabadell Score 1 (poor prognosis in long term) and 2 (poor prognosis in short term) at ICU discharge

Exclusion Criteria:

* patients younger than 18 years old
* patients with Sabadell Score 0 (good prognosis)
* patients with Sabadell Score 3 (null expected survival)
* patients transferred to other hospitals
NeuroLex EEG-Based ADHD Assessment Aid, Pivotal Study

The study will evaluate the effectiveness of a standardized EEG method with the intended clinical users in the intended clinical settings with the intended population (patients who would typically receive a clinician's evaluation for ADHD). Multiple sites will be examined to provide a sample of patients across numerous communities with different demographics. The goal is to evaluate if the predictive accuracy of EEG will not be inferior to that of a widely-used and extensively validated ADHD scale in the prediction of ADHD in the intended use population as evaluated by Best Estimate Diagnosis.


Eligibility Criteria:
Inclusion Criteria:

* Subject willing to voluntarily participate in a research study that includes EEG collection and analysis.
* Family/patient seeking comprehensive clinical evaluation for attention and/or behavior concerns.
* Male or female at least 6 years of age and who will not be over 17.99 years of age upon admission to study.
* Willing to stop any and all current psychiatric medications prior to or by entry into study.
* Subject and parent (or legal representative) of an educational level and degree of understanding sufficient to communicate suitably with the investigator, rater and study coordinator.

Exclusion Criteria:

* Previous diagnosis of mental retardation. IQ \< 70 by previous records.
* History of seizure disorder or of EEG abnormalities. On anticonvulsants for seizure control.
* Metal plate or metal device in the head.
* Suicide ideation or gesture and/or homicidal ideation or gesture.
* Concomitant medications during participation in a research study. No prescription or nonprescription medications with psychoactive properties that may affect EEG (such as over-the-counter dietary supplements, pseudoephedrine, or phenylpropanolamine). No antipsychotics, no psychostimulants, no antidepressants. Washout of at least one week or longer depending on the medication and clinician's judgment. Medication used for medical reasons must be cleared by research staff with consideration of known effects on EEG.
* Known serious medical problems (cardiovascular, hematological, liver, seizure disorder, renal, or chronic respiratory problems).