cyrilzakka/clinical-trials huggingface dataset:
Advancing Discussions Using a Video-based Support Tool About End-of-life Care

The purpose of this study is to evaluate the effectiveness and implementation considerations of a video aid to improve communication and patient-centered outcomes in older injured adults


Eligibility Criteria:
Inclusion Criteria:

* English or Spanish speaking
* admitted to any level of care following trauma

Exclusion Criteria:

* Prisoners
* Existing do not resuscitate (DNR)/do not intubate (DNI)
* Patients admitted while on hospice
* Patients not expected to survive over 24-48 hours
Investigation of the Effectiveness of a Home Exercise Program

The purpose of this study is to examine the effects of a home exercise program on individuals with temporomandibular joint disc displacement with reduction. Participants will be assessed at baseline and again after a four-week home exercise program.

Participants who meet the inclusion criteria will be randomly divided into 2 groups. The first group, called the study group, will receive a home exercise program and patient education. The second group, called the control group, will receive only patient education. Participants will be assessed at baseline and again after a four-week home exercise program.

Eligibility Criteria:
Inclusion Criteria:

* 18 and 65 years,
* who have had complaints related to TMJ for at least 3 months,
* who have been diagnosed with Temporomandibular joint disc displacement with reduction as a result of clinical and radiological evaluation by a dentist

Exclusion Criteria:

* Those with cognitive problems,
* any systemic joint or muscle disease (e.g. fibromyalgia, rheumatoid arthritis),
* serious systemic diseases,
* any neurological disorder (e.g. trigeminal neuralgia),
* pregnancy, breastfeeding,
* who have previously been treated for TMJ or orofacial muscle pain
Chest Drain Insertion Assisted by Virtual Reality

Clinical study aiming to investigate the potential benefit of the use of virtual reality helmet as a distractor during chest drain insertion to alleviate patients\&#39; pain and anxiety


Eligibility Criteria:
Inclusion Criteria:

* Indication of chest drain insertion for pleural effusion or primary spontaneous pneumothorax
* Patient who received clear and loyal information abotu the study protocol
* Patient who consented to participate to the study
* Patient aged 18 years old or older
* Patient affiliated to the french health system

Exclusion Criteria:

* Patient aged less than 18 years old
* Patient in emergency situation
* Patient with severe heart condition
* Patient allergic to silicone
* Patient with severe psychiatric or mental disorder
* patient with binocular vision anomaly
* patient with pacemaker or defibrillator
* patient wearing a hearing aid that cannot be removed
* Patients under the influence of alcohol or drugs, nausea, fatigue, emotional or anxiety disorders, migraine, headaches, infectious disease
* Patient with past medical history of epilepsia or convulsion

  -- Persons covered by articles L. 1121-5 and L1121-8 of the French Public Health Code:
  * Pregnant, parturient or breast-feeding women,
  * Persons of full age subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
  * adults unable to give their consent
  * Persons deprived of their liberty by a judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1.
* Person able to give consent but unable to write
* Person able to give consent but unable to read French
* Patient unable to consent to the study
Study on Mechanisms of Changes in Liver Disease and Sex Steroid Metabolism During Weight Loss

The main objective of the study is to gain insight in the early dynamics and mechanisms of recovery of liver disease and sex steroid metabolism during weight loss in obese men and women and to investigate whether surgical weight loss has differential effects as compared to weight loss with life style measures. In addition, we want to evaluate the postprandial hypoglycemic reactive syndrome (PPHRS) in these patients using a standard chewable meal.

Secondary objectives are investigating determinants for the changes in sex steroids, liver disease and PPHRS. Possible determinants to be investigated are adipocytokine secretion patterns, body composition, resting metabolism rate, weight loss per se and changes in fat distribution, parameters of fatty acid metabolism, ... .


Eligibility Criteria:
Inclusion Criteria:

* Informed consent obtained
* BMI \> 35 kg/m²

Exclusion Criteria:

* Primary or secondary hypogonadism due to genetic causes (Kallman syndrome etc.), tumors, infiltrative diseases, infections, pituitary apoplexy, trauma, critical illness, chronic systemic illness or intentional.
* Type 2 Diabetes Mellitus treated with insulin or GLP-1 analogues
* Current or recent use of insulin, corticosteroids, opiates (on a daily basis), growth hormones, androgen- or estrogen analogs, levothyroxine, anti-retroviral drugs or antipsychotics
* Cancer (within \< 5 years)
* High-grade malignancies
* Serious co-morbidities such as renal, hepatic of cardiac failure
* Known or suspected abuse of alcohol or narcotics
* Mental incapacity, unwillingness, or language barrier precluding adequate understanding or cooperation.
Analysis of Microbiota Variations in Industry Workers Working Different Shifts and Impact of a Nutritional Intervention

Shift workers are a growing population. It is well established that these workers face an increased risk of developing chronic diseases, but the underlying mechanisms remain debated. Various factors such as internal circadian desynchronization, unhealthy lifestyle behaviours, and lack of sleep interact in complex ways. Recently, it has been suggested that the gut microbiota (GM) may play an important role in this increased risk.

The goal of this study is to describe the variations of the GM composition in shift workers across three different rotating weekly shifts (morning, afternoon, night) and to measure the impact of a 3- week walnuts supplementation intervention consisting in a controlled experimental study.

Therefore, we propose a 6-weeks study including an observational and an experimental part. First, in the observational part, we will compare the gut microbiota of shift workers across three shifts (morning, afternoon and night). In the second part of the study, participants will add to their usual intakes a daily serving of nuts (30g). Again, we will compare the gut microbiota composition across the three types of shifts. During the study, participants will record their food intake, sleep and defecation time. We will also monitor their blood glucose levels continuously during the 4 first weeks of the study.


Eligibility Criteria:
Inclusion Criteria:

* Working 3x8 shifts (weekly rotations between AM, PM and N shifts) for at least 3 months prior to the study
* No anticipated changes in shift work planning
* No prebiotics or probiotics supplements.

Exclusion Criteria:

* Antibiotic and/or immunomodulator use in the last 3 months or during the study
* Change in medication during the last month or during study
* Inflammatory bowel disease or important gut surgery
* Nuts allergy
* Major digestive tract surgery.
Graded Activity Training and Task- Oriented Training on Post-Stroke Fatigue

The aim of this randomized controlled trial is to determine the effects of Graded Activity Training and Task Oriented Training on Fatigue in Post-Stroke Patients. Until now there is very limited work found on fatigue so this will increase quality of life in stroke patients and potentially reduce burden on healthcare system.

Post stroke fatigue (PSF) is one of the most common outcomes of stroke. PSF is defined as "overwhelming feeling of exhaustion or tiredness" as a result of stroke PSF is an undesirable outcome by which patient's ability in study participation, adherence to medication and effectiveness of rehabilitation decrease which is unrelated to exertion, and does not typically improve with rest. Prevalence rate of PSF ranges between 25% and 85% One out of two stroke survivors experience post-stroke fatigue. The relationship between physical deconditioning and fatigue is bidirectional there was a negative relationship between fatigue and aerobic fitness in chronic stroke. PSF may arise from physical deconditioning (physical fatigue). Therefore, improving physical endurance through physical activity training could potentially reduce fatigue complaints.

The rationale of this study is to determine how task-oriented training and graded activity training effect stroke patient's levels of fatigue and to develop an improved fatigue management intervention protocol. This study will also determine effects of how both interventions affect Mobility and Gait. By doing so, we can identify a more effective PSF intervention plan, which will help reduce the burden on the healthcare system and will lessen strain on caregivers and in turn enhance patient quality of life.

Eligibility Criteria:
Inclusion Criteria:

* Both male and female of age 40 to 60 years.
* Patient with both ischemic or hemorrhagic stroke.
* Patient with both right and left hemiplegia.
* Checklist Individual (CIS-F) fatigue score of 40 or more.
* Patients who had sustained a stroke more than 4 months before recruitment.
* Patients who can independently walk for 10 meters (about 33 feets)

Exclusion Criteria:

* Patients with severe comorbid health conditions (such as cardiac diseases, pulmonary diseases like COPD, Orthopedic Conditions Arthritis, joint replacements).
* Patients with uncontrolled diabetes, hypertension, Depression and Anxiety.
* Patients who are not willing to participate.
* Patient with any medications that can affect their ability to engage in physical training program like Antidepressants, Beta-Blockers, corticosteroids etc.
* Pregnant women.
An Evaluation of Safety and Efficacy of Anecortave Acetate Versus Placebo in Patients With Subfoveal CNV Due to Exudative AMD

The purpose of this study is to demonstrate that anecortave acetate is superior to placebo in maintenance of visual acuity at the 12- and 24-month visits.


Eligibility Criteria:
Patients at least 50 years of age, of any race, and either sex with a clinical diagnosis of exudative AMD and a primary or recurrent subfoveal CNV lesion in the study eye.
LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients

The purpose of this study is to see if there are physical and emotional benefits to participating in a structured exercise regimen for those who are ages 2-25, are newly diagnosed with a blood or solid tumor cancer, and are currently undergoing or will begin cancer treatment.

This is a randomized, controlled trial to investigate if a structured exercise regimen will have benefit relative to the control arm by increasing and /or maintaining physical functioning in pediatric subjects undergoing chemotherapy and childhood cancer treatment as measured by 6-Minute Walk test and BOT-2 Brief or PDMS-2.

Eligibility Criteria:
Inclusion Criteria:

1. Ages 2-25 at time of consent
2. Subject has newly diagnosed cancer per Investigator, and is planning to undergo chemotherapy for treatment of malignancy for at least 3 full cycles
3. Ability of subject (and/or parent/guardian) to read and understand the English or Spanish language
4. As determined and documented by the enrolling investigator, ability of the subject to understand and comply with study procedures for the entire length of the study

Exclusion Criteria:

1. Known cardiac dysfunction that, in the opinion of the investigator, would be unsafe for the child to participate in the exercise program
2. Recent (within 4 weeks of enrollment) or planned surgery that will result in prolonged limited mobility not amendable to exercise modifications per investigator discretion
3. Primary CNS Tumor
4. Osteosarcoma
REspiratory diSEAse cohoRt Studies of CHinese Medicine for ILD (RESEARCH-ILD)

This study is a traditional Chinese medicine cohort for interstitial lung disease（ILD） in China, including at least 5000 patients with ILD and followed up for at least 5 years. The aim is to focus on the demographic characteristics, clinical features, disease occurrence and development characteristics, TCM syndrome evolution patterns, and clinical efficacy of TCM treatment for ILD in the real world.

This study focuses on ILD patients and adopts a prospective cohort study design, with traditional Chinese medicine treatment as the exposure factor. The subjects are divided into a traditional Chinese medicine cohort and a non traditional Chinese medicine cohort, with demographic characteristics, mortality rate, lung transplant rate, annual acute exacerbation frequency, traditional Chinese medicine syndrome, 6MWT, lung function, dyspnea score, quality of life, and other observation indicators. Follow up for at least 5 years will be conducted, and at least 5000 ILD patients will be included, focusing on the demographic characteristics, clinical characteristics, disease occurrence and development characteristics, traditional Chinese medicine syndrome evolution rules, and clinical efficacy of traditional Chinese medicine treatment for ILD in the real world.

Eligibility Criteria:
Inclusion Criteria:

1. Patients who meet the diagnosis of ILD;
2. Age≥18 years old;
3. Ability to provide independent informed consent.

Exclusion Criteria:

Patients with acute ILD caused by known reasons, but the lesions disappear within 2 weeks after treatment. Example: Interstitial pneumonia caused by infections such as mycoplasma/virus, and those who recover after treatment are excluded.
Trial of Computerized MET for Adolescent Substance Use

The purpose of this study is to test the effects of a computerized, self-directed Motivational Enhancement Therapy program for adolescent substance use (iMET), in comparison to clinician-delivered MET and Treatment As Usual (TAU), on treatment engagement and substance use. The investigators hypothesize that both iMET and MET will be more effective than TAU in engaging/retaining patients in treatment and in reducing substance use during a 12-month follow-up period. The investigators also hypothesize that Self-directed iMET will be as effective as the clinician-guided MET in increasing treatment engagement and abstinence during the 12-months follow-up period.


Eligibility Criteria:
Inclusion Criteria:

* completed initial visit at the treatment program;
* be available to return for iMET/MET sessions (if assigned)
* be available to complete all follow-up measurements
* a past-12-month CRAFFT score \>1
* have used substances on \>6 days (not including tobacco use) during the 90 days preceding their visit

Exclusion Criteria:

* unable to speak and understand English, or read English at a 5th grade reading level
* youth deemed by the clinical team to require immediate hospitalization or referral to more intensive residential treatment
ARV Concentrations in Hair

Hair samples from subjects on antiretroviral therapy, both HIV- and HIV+ patients with HIV RNA \<50copies/mL for \>6 months will be analyzed to investigate the influence of race, hair color and hair treatment on ARV response.

A small thatch of hair (approximately 20 strands) will be collected from 85 participants who are currently taking antiretrovirals (ARVs). Hair collection will be evenly distributed into color cohorts: Black, Brown, Blonde and Grey. Participants will need to be \>80% adherent to their medication and have had an undetectable HIV RNA VL within the previous 6 months. In the lab, samples will be used to develop IR-MALDESI MSI hair protocols for high sensitivity and accuracy to quantify ARVs in 5 therapeutic drug classes (Integrase Inhibitors, Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, Entry Inhibitors, Protease Inhibitors).

Eligibility Criteria:
Inclusion Criteria:

* HIV Negative or HIV positive individuals, aged 18 years or older, who have been taking their ARV medication for at least 3 months and are adherent based on blood plasma HIV RNA of \<50 copies/mL or HIV negative status.

Exclusion Criteria:

* Subjects non-adherent to anti-retroviral regimen
* Subjects not willing or able to provide head hair sample
Bowel Colonization With Multi-drug Resistant Bacterial Species in Hospitalized Patients With acute-on Chronic Liver Failure (ACLF), and Its Relationship With Extra-intestinal Infectious Events and Short-term Outcomes.

Bowel colonization with anti-microbial resistant bacteria increases the risk of clinical infections. Infections caused by anti-microbial resistant bacteria have been associated with increased mortality, prolonged hospital stay, and increased costs. In addition, with the emergence of carbapenemase resistant bacterial species, there may not be any effective therapy for patients infected with such resistant species.

Bowel colonization with anti-microbial resistant bacteria is an established risk factor for infections due to resistant bacteria, especially in transplanted patients and in intensive care unit. In this study we will study whether bowel colonisation in Acute on Chronic Liver Failure patient increases the risk of infection development in extra intestinal sites.


Eligibility Criteria:
Inclusion Criteria:

- Patients with Acute on Chronic Liver Failure admitted to the ward/High Dependency Unit/Intensive Care Unit.

Exclusion Criteria:

1. Patients on immunosuppressant medications or on daily steroids (excluding inhaled steroids) or \>2 weeks.
2. Patients with additional primary or acquired immunosuppressive states like hypogammaglobinemia, post-splenectomy, human immunodeficiency virus (HIV) infection etc.
3. Neutropenia defined as absolute neutrophil count or total white blood cell count (WBC) \<500/mm3
4. Patients with extra-hepatic malignancy or on cytotoxic chemotherapy.
5. Patients with ileus, bowel hypomotility, severe constipation requiring laxatives/purgatives or enemas to evacuate.
6. Patients with fresh or altered blood in stools.
7. Patients with anatomical predisposition to infection/ bacterial seeing like prosthesis or foreign body. Patients with exfoliative skin conditions, significant mucosal ulcerations, or skin ulcers. Patients who have received \> 2 weeks of antibiotics before current admission.
8. Pregnant patients.
Survey of Patient and Physician Knowledge and Perception Regarding Medicare Part D Plan Selection

Evaluation of patients' methodology and ability to select an economical and ideal Medicare Part D prescription drug plan (PDP).

The purpose of this project is to evaluate patients' methodology and ability to select an economical and ideal Medicare Part D prescription drug plan (PDP).

The primary objective of this project is to determine the percentage of patients who are enrolled in Medicare Part D who are currently enrolled in their ideal plan based on estimated costs.Secondary objectives are to determine:

1. The percentage of patients who have switched or considered switching their Medicare Part D PDP at any point during their enrollment
2. The most commonly used resources used by beneficiaries to aid in selection of a Medicare Part D PDP
3. The percentage of patients who reach the Medicare Part D donut hole as a result of their current plan
4. Physician perception of appropriate selection of Medicare Part D PDP among their patient panel
5. Physician perception of administrative time spent resolving medication issues related to Medicare Part D PDPs

Eligibility Criteria:
Patient Population

Inclusion Criteria:

* Patient of Martha Morehouse General Internal Medicine Clinic at the Ohio State University Wexner Medical Center
* Medicare A/B is listed as primary insurance
* Patients 65 years old or older

Exclusion Criteria:

* Patients less than the age of 65 years old
* Patients with Medicare Advantage plan

Physician Population

Inclusion Criteria:

* Physicians of Martha Morehouse General Internal Medicine Clinic at the Ohio State University Wexner Medical Center
A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Patch Applied To The Skin

This study will evaluate the single-dose pharmacokinetics, safety, and tolerability of a varenicline patch applied to the skin.


Eligibility Criteria:
Inclusion Criteria:

* Healthy, Caucasian, male, adult light to regular smokers

Exclusion Criteria:

* Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
* Any condition possibly affecting drug absorption through the skin (eg, psoriasis).
Impact of the Pharmaceutical Care on the Quality of Life in Patients With Chagas Heart Disease

The investigators hypothesize that pharmaceutical care may constitute an important tool for the clinical management of these patients by improving their compliance to their treatment with consequent improvement in their quality of life by minimizing symptoms, and decreasing the number of hospital admissions and adverse drug reactions. Therefore, the aim of this trial is to evaluate the contribution of pharmaceutical care to clinical treatment of patients with Chagas heart disease complicated by heart failure.

Study Type: Interventional

Study Design: A total of 88 patients will be randomly assigned into two parallel groups: (1) group who will receive standard care and pharmaceutical care; and (2) group who will receive only standard care. Both groups will be subjected to a follow-up period of 12 months. The primary outcome of this trial is the evaluation of quality of life, measured by the 36-item short-form and the Minnesota Living with Heart Failure Questionnaire. Secondary outcomes include drug-related problems and exercise tolerance measured by the standard six-minute walk test.


Eligibility Criteria:
Inclusion Criteria:

* The proposed clinical trial will be conducted in volunteers with Chagas disease complicated by heart failure.
* Subjects will include adults, men and women, racial or ethnic minorities.
* Diagnosed by two distinct Chagas serology tests (indirect immunofluorescence and enzyme linked immunosorbent assay

Exclusion Criteria:

* Patients with any of comorbidities that significantly affect the cardiac performance, such as coronary artery disease, moderate or severe heart valvular disease, left ventricular (LV) hypertrophy, congenital heart disease, or that limit their survival, such as malignant tumors and HIV, will be excluded from the study.
* Patients will be also be excluded in case of failure to give informed consent, inability to perform 6 minute- walk test, significant cognitive impairment, or pregnancy.
* Individuals who are participating in others intervention trials will also be excluded.