cyrilzakka/clinical-trials huggingface dataset:
Study on Cannabinoid Receptor Expression in Gastrointestinal Diseases

The purpose of the study is to investigate phospholipid ligands and their receptors in inflammatory bowel diseases and colon cancer. Several new species of lipids have been recently discovered which are able to transmit information to cancer cells in the large intestine. The lipids and their responsive receptors build an axis that is thought to influence the development of inflammation and cancer.

Expression of cannabinoid receptors are examined in mucosal biopsies of the colon and blood leukocytes of patients with inflammatory bowel disease (IBD) or colon cancer in comparison to healthy individuals by polymerase chain reaction, Western Blots and flow cytometry. Colonic endoscopic biopsies and blood are collected from adult patients with confirmed active Ulcerative colitis (UC) and Crohn's disease (CD), adult UC and CD patients in remission, colon cancer patients and from healthy individuals (controls). Biopsies from healthy individuals (control group) will have undergone colonoscopy during standard screening for colorectal cancer or for the diagnostic workup of gastrointestinal symptoms without endoscopic or histologic evidence of colonic disease. For UC patients, duration and location of disease (Montreal classification), endoscopic (Mayo score) and clinical activity score, histological features and current and previous treatments (5-aminosalicylic acid, corticosteroids, immunomodulators) will be recorded. For CD patients, duration and location of disease is assessed, a HarveyBradshaw Index and activity will be scored, histological features and current and previous treatments will be recorded. Blood is collected and immediately processed for flow cytometric experiments. Phospholipids are measured in serum and in colonic mucosal biopsy samples of all cohorts by mass spectrometry.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of Ulcerative colitis (active/remission)
* or Crohn's disease (active/remission)
* or Colon cancer (or metastasis)

Exclusion Criteria:

* unable to give informed consent
* pregnancy
* intermittent illness or comorbidity during Crohn/Ulcerative colitis
Effects of C-MAC Videolaryngoscope, McGRATH Videolaryngoscope and Macintosh Direct Laryngoscope on Intraocular Pressure and Hemodynamics

In this study, participants aimed to compare the effects of direct laryngoscopic endotracheal intubation and videolaryngoscopic intubation with C-MAC videolaryngoscope and McGrath videolaryngoscope on intraocular pressure and hemodynamics.

The maintenance of airway opened is one of the main responsibility of the anesthetist. Intubation procedure during anesthesia application benefits such as airway opening, airway and breathing control, aspiration hazard, respiratory effort and dead space reduction, surgical comfort and airway control during resuscitation. Laryngoscopy and tracheal intubation increases in heart rate, blood pressure and the intraocular pressure. The sympathetic-adrenal activity caused by the stimulation of the laryngeal and tracheal tissues is responsible for these negative effects. Endotracheal intubation with videolaryngoscopy is an alternative method used in airway management. Laryngoscopy and tracheal intubation under general anesthesia and laryngeal mask and airway control techniques cause different hemodynamic and catecholamine levels.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologist Score 1-2
* Mallampati 1 ve 2

Exclusion Criteria:

* Glaucoma,
* Diabetes mellitus
* Cardiovascular and pulmonary disease
* American Society of Anesthesiologist Score III-IV
* Bdoy mass index greater than 35
* Difficult intubation history
* Obstetric surgery
* Propofol, fentanyl, rocuronium contraindication
Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery

The purpose of the study is to evaluate the efficacy of pre-emptive paracetamol in reducing intra operative pressure and post operative pain after surgical removal of impacted mandibular third molar using visual analogue scale


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 21 years and above
* Healthy patients (ASA I)
* Patients who are not allergic to the drugs and local anesthetic agents used

Exclusion Criteria:

* Patients who are on concurrent treatment with NSAIDs or corticosteroids
* Patients with pericoronitis or periapical infection
Does Mixing Alcoholic Drinks Make Hangover Worse?

Does mixing alcohol make hangover worse?

Hangover is the most commonly occurring morbidity associated with heavy drinking.

Our aim was to test the hypothesis that mixing alcoholic drinks as compared to drinking one type of alcohol only (beer, wine or spirits) associate with a higher alcohol intake and worse hangover.

Eligibility Criteria:
Inclusion Criteria:

* written and oral consent
* minimum 18 years old
* participating in Danish Health Research Retreat in Turkey 2016
* will consume alcoholic beverages

Exclusion Criteria:

* underage
* will not consume alcoholic beverages
Substitution of Acetate by Citrate in the Bicarbonate Based Hemodialysis

Acetate is the primary acidifying solution used in bicarbonate-based hemodialysis worldwide. It has been published in small trials or case series that the addition of acetate is associated with a rise in nitric oxide production of vascular smooth muscle cells, endothelial cells and myocardial cells as a sign of vascular dysfunction. Furthermore clinical side effects of dialysis e.g. nausea, malnutrition, intradialytic blood pressure drops, induction of proinflammatory cytokines and activation of complement and leukocytes have been described with acetate.

Citrate on the other hand was associated with: Acid-base disorders (metabolic alkalosis), Disturbances of the calcium homeostasis (Hypocalcemia), but also anti-inflammatory effects. Both dialysate additives (citrate and acetate) are commercially available and are used world wide in dialysis centers.

The investigators hypothesize that substitution of acetate by citrate reduces the cardiovascular risk (measured by a change in the surrogate parameter of pulse wave velocity and Augmentation index) and might improves quality of life in the participants. Furthermore the investigators speculate that citrate in the dialysis solution could reduce systemic inflammation in the participants of the study.


Eligibility Criteria:
Inclusion Criteria:

* time since initiation of dialysis \> 3 months
* age \> 18 years
* dialysis 3x/week for \> 4 hrs

Exclusion Criteria:

* ongoing infection
* pregnancy
* lack of written and informed consent
A Pilot Study to Explore the Role of Gut Flora in Elevated Cholesterol

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Elevated Cholesterol.

The goal of this Research Study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding Elevated Cholesterol.

Eligibility Criteria:
Inclusion Criteria:

1. Signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study
2. Male or female patients of any age (interest is given to children to compare with mothers).
3. LDL\>100
4. Total Cholesterol\>200

Exclusion Criteria:

1. Refusal to sign informed consent form
2. History of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy.
3. Postoperative stoma, ostomy, or ileoanal pouch
4. Participation in any experimental drug protocol within the past 12 weeks
5. Treatment with total parenteral nutrition
6. Any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial
7. Inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study
Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention Study

This study investigates potential protective effect of atorvastatin pre-treatment in patient with stable coronary artery disease undergoing percutaneous coronary intervention (PCI). Patient are randomized to two groups: atorvastatin pre-treatment group (80mg atorvastatin two days before PCI) and control group (PCI without atorvastatin pretreatment). Endpoint is myocardial infarction measured by troponin I and creatine kinase myocardial band.

Randomized studies have shown that pre-treatment with atorvastatin may reduced periprocedural myocardial in patient with stable angina during elective PCI. These data provide evidence-based support for using atorvastatin 7 days before PCI (dosage 40mg/d), alternatively three or more days (unknown dosage). We want to confirm this results for shorter pre-treatment period (two days) with dosage 80mg per day.

Eligibility Criteria:
Inclusion Criteria:

* stable angina in last month
* indication for percutaneous coronary intervention
* informed consent

Exclusion Criteria:

* acute coronary syndrome in last 14 days
* renal insufficiency (creatinine more 150 µmol/l)
* diseases severely limiting prognosis
* immunosuppressive treatment
* statin one month before randomization
* occlusion of the coronary artery
* previous participation in this study
Prehospital Emergency Care of Obstructive Respiratory Emergencies With the Use of Teleconsultation

The aim of the study is to investigate the quality of prehospital emergency care in acute respiratory emergencies, when paramedics are supported telemedically by an EMS physician.

Six ambulances from five different Emergency Medical Service (EMS) districts are equipped with a portable telemedicine system. In cases of acute obstructive, respiratory emergencies the paramedics can use this system to contact a so called "tele-EMS physician" after consent of the patient was obtained. The tele-EMS physician has an audio-connection to the EMS team and receives vital parameters (e.g., ECG, pulse oximetry, non-invasive blood pressure) in real-time. The transmission of still pictures (taken with a smartphone), 12-lead-ECGs and video streaming from the inside of the ambulance can also be carried out, if indicated. The tele-EMS physician supports the EMS team in obtaining all relevant medical history, diagnosis and can delegate the application of medications. This can be carried out to bridge the time to the arrival of an EMS physician or in less severe cases without an EMS physician on-scene. The quality of prehospital care and the possible influences on the initial inhospital phase should be investigated and compared with regular EMS.

Eligibility Criteria:
Inclusion Criteria:

* Obstructive, respiratory emergency
* Verbal consent for teleconsultation obtained or patient is not able to consent due the severity of the emergency

Exclusion Criteria:

* No respiratory emergency
* Refused consent for teleconsultation
Evaluation of Xylitol Wipes as an Oral Hygiene Protocol for Haemophilic Children

The purpose of this study is to evaluate xylitol wipes as an oral hygiene protocol for haemophilic children


Eligibility Criteria:
Inclusion Criteria:

* Hemophilic children A or B with No other systemic diseases.
* Aged (6-12 years).
* Co-operative.

Exclusion Criteria:

* Children on long-term antibiotics
Fibrinolytic Deficit in Patients With Acute PE

Fibrinolysis is the body's process that prevents blood clots. The investigators hypothesize that patients presenting with acute pulmonary embolism (PE) or blood clots in the lungs differ in their fibrinolytic deficit phenotype. The investigators aim to use biomarkers directly involved in endogenous fibrinolytic cascade including PAI-1, Alpha-2-Antiplasmin (A2A), TAFI, D-dimer, and Fibrinogen to phenotypically characterize patients presenting with acute PE and to correlate these biomarkers with clinical, echocardiographic, computed tomography (CT), and functional status outcomes.

Patients (n=100) identified by the Pulmonary Embolism Response Team (PERT) suffering from a PE will be identified by the PI. Blood plasma samples from these patients which have been drawn for routine lab tests will be identified and the Sub-I who will pick the samples up from the clinical lab after the routine analysis has been completed. These samples will be de-identified by giving them a study number. These samples will be recentrifuged and aliquoted. Samples will be stored in a -80ᵒC freezer in the Hemostasis \& Thrombosis Research Laboratory. When all 100 de-identified samples have been collected they will be analyzed blindly by the technical staff of the hemostasis laboratory for the fibrinolytic parameters PAI-1, Alpha-2-Antiplasmin, TAFI, tPA, D-dimer, Plasminogen, and Fibrinogen. PAI-1 and TAFI will be quantified with an Enzyme Linked-Immuno-Sorbent Assay (ELISA), while A2A is measured using functional assay. PAI-1 is measured as ug/ml, while TAFI and A2A are measured as % of normal controls. Normal controls are derived from pooled normal human plasma from volunteers purchased from outside vendor. Results will be compiled and sent to the PERT team for analysis and correlation withclinical, echocardiographic, computed tomography (CT), and functional status outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Patients age 18 - 90 years
* Patients suffering an acute PE
* Blood collected for clinical evaluation of PE

Exclusion Criteria:

* Blood not collected or not sufficient quantity/quality
Potential Impact of Neuroimmune and Autophagic Alterations on the Progression and Severity of Human Atherosclerotic Process

The hypothesis of this study is that neural regulations of the atherosclerotic plaque, identified in the murine model of atherosclerosis, could also exist in human pathology. The dysregulation status of the autonomic nervous system is typical of several cardiovascular diseases, but the role it exerts in the modulation of important mechanisms at the basis of the atherosclerotic process progression has not been investigated yet. The main aim of this study will be to investigate, in the atherosclerotic plaque, the alterations of inflammatory and immune processes, the neural modulations and the presence of dysregulations of the autophagic process. The investigators will also associate the potential presence of neural modulations of the plaque to its stability/instability, from a clinical-translational point of view. Finally, the investigators aim at providing a solid basis for the development of novel therapeutic strategies, which could reduce the elevated health and welfare costs for the clinical management of cardiovascular pathologies such as atherosclerosis.


Eligibility Criteria:
Inclusion Criteria:

* age ≥ 45 and ≤ 90 years;
* patients with severe (70-99%) carotid stenosis, diagnosed with color doppler echography or angio-MRI or angiography;
* written informed consent.

Exclusion Criteria:

* carotid stenosis \<70% at carotid bifurcation or diagnosed with color doppler echography or angio-MRI or angiography;
* severe neoplasia;
* participation to other clinical trial, ongoing or terminated less than one month before enrolment in this study.
Evaluation of the Dietary Supplement Refill Bypass to Reduce Nutritional Deficiencies of Patients Who Underwent Bariatric Surgery

This is a cohort, observational, prospective, multicenter, longitudinal study. 100 patients will be followed postoperatively for a period of 12 months. Intermediate statistical analyzes will be performed at 1 month, 3 months, 6 months and 9 months.

This observational study is non-interventional, it does not change the usual care of patients who underwent a bariatric surgery. Data collection will be carried out during routine visits planned in the post-operation usual follow-up. The blood tests are part of the patient's usual care for his bariatric surgery.

Surgeons will include patients for whom they have freely decided to use the dietary supplement Refill under the care of the treatment of obesity. The motivation of the patient and his commitment to the project is evaluated by the surgeon.

The main objective is to evaluate the efficacy of the dietary supplement Refill.

The primary endpoint is the reduction of iron deficiency.


Eligibility Criteria:
Inclusion Criteria:

* Patient with a scheduled bariatric surgery "gastric bypass",
* Patient who performed a blood test before surgery,
* Patient compliant.

Exclusion Criteria:

* Allergy to components of the dietary supplement,
* Pregnancy or breastfeeding,
* Any biological abnormality considered by the investigator significant.
Masitinib in Refractory Active Rheumatoid Arthritis

The objective is to compare efficacy and safety of masitinib at 3 and 6 mg/kg/day to methotrexate, with a randomisation 1:1:1, in treatment of patients with active rheumatoid arthritis with inadequate response to 1. methotrexate or to 2. any DMARD including at least one biologic drug if patients previously failed methotrexate or to 3. methotrexate in combination with any DMARD including biologic drugs.


Eligibility Criteria:
Inclusion Criteria:

1. Patient with rheumatoid arthritis diagnosed according to American College of Rheumatology (ACR) criteria for at least 6 months
2. Patient with ACR functional class I-III
3. Patient who have active RA
4. Patient who failed (defined as active RA with stable dose during 3 months) methotrexate or any DMARD including biologics drugs if patients previously failed methotrexate or methotrexate in combination with any DMARD including biologics drugs
5. Patient with a disease onset at \> 16 years of age

Exclusion Criteria:

1. Patient for whom the use of methotrexate is contraindicated as per its SPC
2. Patient with documented fibromyalgia
3. Patient with lactose intolerance
4. Patient presenting with cardiac disorders
Social Media-Based Education on Cancer Screening Awareness in Women: A Randomized Controlled Trial

This randomized controlled trial investigates the impact of a social media-based educational program on women's knowledge, attitudes, and digital health literacy regarding breast, cervical, and colorectal cancer screenings. The intervention is based on the Socio-Ecological Model and aims to improve awareness and screening participation. Participants in the intervention group receive daily educational content for 8 weeks via social media platforms (WhatsApp/Instagram), while the control group receives two standard online education sessions via Microsoft Teams app. The study includes 132 women aged 30 to 70 in Türkiye who have not previously participated in cancer screenings. The primary outcomes include changes in cancer knowledge, attitudes, and digital health literacy levels measured by validated scales.

This study is a randomized controlled trial designed to evaluate the effect of a social media-based educational intervention on women's knowledge, attitudes, and digital health literacy regarding cancer screenings. The trial will include 132 women between the ages of 30 and 70 who have never undergone breast, cervical, or colorectal cancer screening. Participants are recruited through health institutions and randomized into two parallel groups: the intervention group and the control group.

The educational intervention was developed in accordance with the Socio-Ecological Model (SEM), incorporating individual, interpersonal, institutional, community, and policy-level messages. The intervention group receives 56 infographics and/or videos total over 8 weeks via closed WhatsApp and Instagram groups. The content includes evidence-based information on cancer epidemiology, risk factors, symptoms, screening methods, healthy lifestyle behaviors, and digital health tools such as e-Nabız and MHRS.

The control group receives traditional education via two 40-minute online sessions (1 week apart), covering the same content without daily engagement. The outcomes will be measured using validated instruments to assess changes in participants' knowledge of cancer screenings, their attitudes towards screening, and their digital health literacy. Data collection will take place before and after the intervention period. The study has been approved by the Istanbul Medipol University Non-Interventional Clinical Research Ethics Committee (Approval Number: E-10840098-202.3.02-7880).

This research is expected to contribute to public health strategies that use digital platforms to enhance cancer screening behaviors and improve health literacy among women.

Eligibility Criteria:
Inclusion Criteria:

* Female participants aged 30 to 70 years
* Use Instagram and/or WhatsApp actively
* Literate and able to complete online forms
* Voluntarily consent to participate

Exclusion Criteria:

* Diagnosed with any type of cancer
* Have undergone previous cancer screening
Interventions to Improve HIV Care Engagement After Hospital Discharge

A quasi-experitmental study of the efficacy interventions, including additional HIV care team daily inpatient round and three telephone calls to remind the upcoming clinic appointment, in improving HIV care engagement within 30 days after hospital discharge among HIV-infected patients.


Eligibility Criteria:
Inclusion Criteria:

* HIV-infected patients hospitalized at Thammasat University Hospital during the study period

Exclusion Criteria:

* The patients who die during admission, are readmitted prior to 30 days after discharge or with incomplete data
* Readmission episodes of the same enrolled patients during the study period
Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism

To evaluate long-term results of adrenalectomy for primary aldosteronism (PA) and to identify prognostic factors associated.

Exhaustive retrospective review of all consecutive patients undergoing adrenalectomy for PA between 2002 and 2013 in our department. All patients underwent preoperative: clinical evaluation (age, sex, height, weight, systolic and diastolic BP under treatment, identification of anti-hypertension treatment), biological evaluation (potassium, renin, aldosterone) and radiological evaluation (CT and/or MRI). Blood pressure was assessed postoperatively at 1 month, 1 year, then at the date of the latest news. The patients were classified into three categories: cured (no antihypertensive therapy in postoperative associated with strictly lower blood pressures of 140/90mmHg), improved (decreased number of drugs or number unchanged but with better blood pressure control), and refractory (no change in the number of drug and blood pressure, or deterioration of one or other of these two parameters).

To evaluate long-term results of adrenalectomy for primary aldosteronism (PA) and to identify prognostic factors associated.Exhaustive retrospective review of all consecutive patients undergoing adrenalectomy for PA between 2002 and 2013 in our department. All patients underwent preoperative: clinical evaluation (age, sex, height, weight, systolic and diastolic BP under treatment, identification of anti-hypertension treatment), biological evaluation (potassium, renin, aldosterone) and radiological evaluation (CT and/or MRI). Blood pressure was assessed postoperatively at 1 month, 1 year, then at the date of the latest news. The patients were classified into three categories: cured (no antihypertensive therapy in postoperative associated with strictly lower blood pressures of 140/90mmHg), improved (decreased number of drugs or number unchanged but with better blood pressure control), and refractory (no change in the number of drug and blood pressure, or deterioration of one or other of these two parameters).

Eligibility Criteria:
Inclusion Criteria:

* Patients \>25 years and \<80 years patients undergoing adrenalectomy for PA
* All patients underwent preoperative: clinical evaluation (age, sex, height, weight, systolic and diastolic BP under treatment, identification of anti-hypertension treatment), biological evaluation (potassium, renin, aldosterone) and radiological evaluation (CT and/or MRI).

Exclusion Criteria:

* patients \<25 years
* patients \> 80 years