cyrilzakka/clinical-trials huggingface dataset:
Motion Capture and Analysis of NYIT Athletes

The purpose of this research is to:

1. determine the normal or existing dynamic biomechanics of college athletes and
2. test the effectiveness of osteopathic manipulative medicine in the treatment of athletic injuries.

Motion capture using Vicon systems allows researchers to quantify characteristics of a body such as the range of motion of the hip or shoulder during an athletic technique such as kicking or shooting a basketball into the basket. The quantified information has been used before to better understand human mobility and performance. Osteopathic manipulative medicine (OMM) is manual medicine applied to joints, muscles, and connective tissue with a goal of improved body functions. Research demonstrating effectiveness of OMM on the musculoskeletal and associated connective tissue systems health includes, among others, prospective clinical trials of OMM for treatment of neck pain, low back pain, and acute first- and second-degree ankle sprains.

Volunteers for the study will be recruited through their Athletic director, coach, or physician by an announcement made verbally or via email. The motion capture will be performed under Matthew Cornelius, MS using the Vicon Bonita Motion Capture system in the Fine Arts Department of NYIT. Following the motion capture, body biomechanics will be analyzed to determine the range of motion of each joint in sagittal, frontal, and horizontal planes as well as the timing and sequence of the movements. The motion analysis will be compared to the Sports Physical exam, including the general, structural/neuromusculoskeletal, and central neurological (ImPACT) exams. The comparison will add validity to the physical exam. In addition, determining if the quantitative, 3-dimensional motion analysis can be correlated with information from the physical exam with regards to restrictions to motion may be useful for athletes to optimize their abilities in the future. If during the course of the athlete's training and competition season s/he sustains an injury, s/he will be evaluated by the NYIT athletics physician, who will randomly assign the injured athletes to either the 'standard of care without OMM' or 'standard of care with OMM' cohorts when medically appropriate. OMM will be performed by an NYITCOM physician specializing in family medicine and OMT or neuromusculoskeletal systems and OMM. "Return to play' time and post-intervention/post-control quantitative motion analysis of biomechanics during the athletes demonstration of the same athletic maneuvers as before the injury.

Eligibility Criteria:
Inclusion Criteria:

* athlete at new York Institute of Technology
* approval by NYIT Athletics Physical for participation in sports
* no current injury

Exclusion Criteria:

* illness preventing participation in sports
* any current injury
* younger than 18 years of age
* pregnancy
* allergy to spandex, nylon, or polyester
Transcutaneous Afferent Patterned Stimulation (TAPS) for Reduction of Parkinson's Disease (PD) Related Action Tremor

Demonstrate safety and efficacy of TAPS delivered by a Cala device as a treatment for action tremor in subjects with Parkinson's disease hand tremor

40 patients with PD with at least mild postural tremor were enrolled in a four-week, prospective, single-arm, open-label study of twice daily TAPS therapy. Due to the COVID-19 pandemic, TAPS devices were shipped to patients to run the study remotely. Unsupervised motion assessments were captured at home, and at the beginning and end of the four weeks by telemedicine.

Eligibility Criteria:
Inclusion Criteria:

* Must be ≥22 years of age
* Competent and willing to provide written, informed consent to participate in the study
* Clinically significant postural tremor as defined by:

  * Dominant hand/arm exhibiting postural tremor ≥ 2 (while in the off state) as assessed by the MDS-UPDRS postural tremor score
* Stable dose of Parkinson's disease medications, if applicable, for 30 days prior to study entry
* Willing to comply with study protocol requirements including:

  * Having the ability to do telemedicine or video calls for study visits
  * remaining on a stable dosage of Parkinson's medications, if applicable, during the duration of the study
  * no significant caffeine consumption within 8 hours of study visits

Exclusion Criteria:

* Implanted electrical medical device, such as a pacemaker, defibrillator, or deep brain stimulator
* Suspected or diagnosed epilepsy or other seizure disorder
* Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site
* Peripheral neuropathy affecting the tested upper extremity
* Presence of any other neurodegenerative disease or dementia. These may include: multisystem atrophy, progressive supranuclear palsy, dementia with Lewy bodies, and Alzheimer's disease.
* Botulinum toxin injection for hand tremor within 6 months prior to study enrollment
* Are participating or have participated in another interventional clinical trial in the last 30 days which may confound the results of this study, unless approved by the Sponsor
* Significant caffeine consumption within 8 hours of study enrollment, which may confound the results of the study, where significant caffeine is considered more than 95 mg (equivalent to a cup of coffee).
* Subjects unable to communicate with the investigator and staff
* Any health condition that in the investigator's opinion should preclude participation in this study
* Pregnancy or anticipated pregnancy during the course of the study
Establishment and Application of an Artificial Intelligence Algorithm for Automatic Identification of Intraoperative Bleeding During Laparoscopic Pancreaticoduodenectomy

Surgeons will label surgical videos of laparoscopic pancreaticoduodenectomy with bleeding information from multicenter. The labeled surgical video will be used as training material to train the algorithmic model so as to build an artificial intelligence algorithm that can automatically identify intraoperative bleeding in this surgery. Then, we will test the performance capability of the algorithm.


Eligibility Criteria:
Inclusion Criteria:

1. surgical videos that recorded complete laparoscopic pancreaticoduodenectomy including resection and reconstruction phases.

Exclusion Criteria:

1.surgical videos that recorded laparoscopic pancreaticoduodenectomy combined with resection and reconstruction of mesentericoportal vein.
MicroRNA Expression in Human Blood Serum and Vitreous Body

MicroRNAs are important regulators of many cellular functions but their expression profile in human vitreous is still unclear. Aim of this study is to investigate microRNA expression profile by PCR in human vitreous of macula hole patients which is suggested to be similar to that of healthy patients.


Eligibility Criteria:
Inclusion Criteria:

* Female macula hole patients without previous ocular or systemic disease.
The Effects of Preloading Before Beach Chair Position

The main objective of this study is whether preloading before positioning would be effective for less hemodynamic instability. The study also analyzes that patients with preloading will decrease postoperative nausea and vomiting, better surgical satisfaction and shortened the duration of surgery and anesthesia.

Keeping patients in normovolemic state and hemodynamically stable in anesthesia and intensive care practice are important goals of anesthesiologist. It is known that hypotension that develops after taking patients to the beach chair position has a negative effect on cerebral oxygenation. Aggressive fluid regimes using to prevent hypotension can cause glycocalyx damage, edema and organ dysfunction. Also hypertension seconday to vasopressor therapy can cause bleeding at the surgical site and impaired surgical visualization during the arthroscopic shoulder surgery.

In the literature, there are studies examine whether the hypotension is the result of decreased cardiac output or decreased systemic resistance and what should be the optimal treatment , but as far as investigators know, there is no study about effects of preloading before the beach chair position on hemodynamic parameters.

Eligibility Criteria:
Inclusion Criteria:

* undergoing elective arthroscopic shoulder surgery in the BCP,
* age older than 18 years and younger than 65 years,
* the American Society of Anesthesiologist (ASA) physical status of I or II,
* accepting the study protocol.

Exclusion Criteria:

* preoperative arrhythmia,
* significant heart failure
* valvular heart disease,
* preexisting cerebrovascular disease,
* deciding to switch to open surgery,
* vasopressor infusion during the surgery,
* using angiotensin converting enzyme inhibitors (ACEI) orangiotensin receptor blockers (ARB) as antihypertensive medication.
A Study Comparing Two Monofocal, Aspheric, Hydrophobic Acrylic Intraocular Lenses: the Alcon CLAREON® and the Abbott Medical Optics PCB00

This is a bilateral randomised controlled study to compare visual performance, refractive outcome, forward light scatter, patient satisfaction and objective measurement of glistenings following insertion of two monofocal, aspheric, hydrophobic acrylic intraocular lenses (IOLs). A new product is compared with an established one.


Eligibility Criteria:
Inclusion Criteria:

* bilateral cataracts
* good visual potential
* ability to understand informed consent and objectives of the trial
* not-pregnant
* not breast feeding
* no previous eye surgery
* corneal astigmatism less than 1 diopter in both eyes

Exclusion Criteria:

* age-related macula degeneration
* glaucoma
* previous retinal vascular disorders
* previous retinal detachment or tear
* any neuro-ophthalmological condition
* any inherited retinal disorder or pathology
* previous strabismus surgery or record of amblyopia
* previous transient ischaemic attacks, cerebrovascular events or other vaso-occlusive disease
* already enrolled in another study
* Exclusion criteria relate to clinical contraindications for Femtosecond Laser Assisted Cataract Surgery, such as:

  * Significant corneal opacities
  * Small pupils following pharmacological dilatation
  * Patients unable to lie sufficiently flat so as to be positioned underneath the laser machine
Relapse Prevention in First Episode Schizophrenia: a 5 Year Trial

Objective: to evaluate the effectiveness of specialised and sustained intervention with or without parent groups during the initial phase of schizophrenia or related disorders on relapse prevention

Methods: A three conditions randomized trial with a duration of five years

Participants: 200 consecutively referred patients aged 15-28 years with a first psychotic episode of schizophrenia or related disorder

Treatment-conditions: Specialized Treatment of early schizophrenia (ST), ST including Parent groups (ST+P) and Treatment As Usual (TAU).

Outcome-measures: cumulative relapse rates and time to first relapse after first remission. Secondary outcome measure: social functioning.

Statistical analysis: cumulative relapse rates using life-table methods. The effect of the three interventions on time to first relapse after remission will be compared using Cox regression analysing intention to treat (ITT) grouping.

Evidence for optimal duration and necessary ingredients of early and sustained specialized treatment from first episode psychosis till the end of the initial phase schizophrenia is still insufficient. Randomized trials with a treatment duration of six months to two years with favorable symptomatic and psychosocial results disappeared at five year follow-up. Other studies suggest that specialized treatment should last 5 years in order to be able to prevent instead of only delaying clinical and psychosocial deteriorating.

In this study we examine both the symptomatic (relapse) and psychosocial outcome of a three armed five year randomized trial in the initial phase of schizophrenia.

Eligibility Criteria:
Inclusion Criteria:

* Patients were eligible for the study if they: 1) met DSM-IV-Revised criteria for schizophrenia or related disorders, 2) were suffering from a first psychotic episode and 3) were living in contact with parent(s) or other relatives.

Exclusion Criteria:

* Patients with drug-related psychoses were not included.
Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI)

The purpose of this study is to determine if using microdots of hyaluronan (PICSI) to select sperm for ICSI will result in increased pregnancies especially with men that have a low hyaluronan binding score (HBA).


Eligibility Criteria:
Inclusion Criteria:

* IVF patients who require the ICSI procedure and whose care is being managed by the clinical and scientific staff of the participating groups, will be included in the study.

Exclusion Criteria:

* IVF patients who do not require the ICSI procedure will be excluded from the study. In addition the following groups of patients will also be excluded:

  * Patients using testicular sperm.
  * Patients using donor sperm.
  * Patients where the female partner is over 40 years of age
  * Patients who have an initial HBA score less than or equal to 2%
  * Patients who have a sperm count less than or equal to 10,000 motile sperm per ml.
  * Patients who produce less than 4 Metaphase II oocytes
Quality of Postoperative Recovery (QoR-15T) in Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS)

Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique that provides faster recovery after thoracic surgery. Techniques such as thoracic paravertebral block, Erector Spina Plane Expansion (ESP block) are accepted as loco-regional techniques for VATS. The quality of recovery after anesthesia (QoR) is an important information of the early health components of patients after surgery. QoR-15 offers a valid, reliable, sensitive and easy-to-use method for recovery after surgery. We aimed to investigate the relationship between QoR-15 score and postoperative pain temperature after Video-Assisted Thoracoscopic Surgery (VATS) ESP block and paravertebral spread.

Video-assisted thoracoscopic surgery (VATS) is a minimally invasive technique that provides faster recovery after thoracic surgery. Techniques such as thoracic paravertebral block, Erector Spina Plane Expansion (ESP block) are accepted as loco-regional techniques for VATS. Despite the improvement in invasiveness against thoracotomy treatment, postoperative pain after VATS was still moderate to severe. In order to accelerate the recovery of patients, a multimodal analgesic should be carefully planned and where it will be beneficial. The quality of recovery after anesthesia (QoR) is an important information of the early health components of patients after surgery. The performance of QoR-15 has been translated into Turkish and validation studies have been conducted on its products. QoR-15 offers a valid, reliable, sensitive and easy-to-use method for recovery after surgery. We aimed to investigate the relationship between QoR-15 score and postoperative pain temperature after Video-Assisted Thoracoscopic Surgery (VATS) ESP block and paravertebral spread.

Eligibility Criteria:
Inclusion Criteria:

* ASA1-3
* Patient undergoing Video Assisted Thoracoscopic Surgery (VATS)
* Over 18 years of age

Exclusion Criteria:

* Sympathectomy, lobectomy and pneumonectomy surgery using Video Assisted Thoracoscopic Surgery (VATS)
* Cases that started with Video Assisted Thoracoscopic Surgery (VATS) but were converted to thoracotomy,
* Patients who were uncooperative,
* Patients who refused to participate in the study,
* Presence of a neuropsychiatric disorder that could bias QoR-15T measurements or emergency surgical intervention,
* Patients under 18 years of age.
The Effects of High-dose Dual Therapy With Probiotics on Gut Microbiota for Helicobacter Pylori Rescue Treatment

The aim of this study was to evaluate the effects of High-dose Dual therapy combined with probiotics on the gut microbiota for Helicobacter pylori rescue treatment.

The combination of vonoprazan (VPZ) and amoxicillin (VA therapy) has been shown to achieve notable eradication rates for Helicobacter pylori (H. pylori). Patients who receive this treatment are prone to adverse reactions, such as diarrhea, abdominal distention. We plan to combine probiotic with the above treatment. However, it is not clear what changes in gut microbiota and metabolism may result from this therapy.

Eligibility Criteria:
Inclusion Criteria:

* Age from 18 to 65 years;
* H.pylori infection diagnosed by 13C-urea breath test;
* A period of more than two months since the last eradication therapy for H. pylori;
* Patients who had previously failed 2 or more eradication regimens.

Exclusion Criteria:

* Allergy to any of the medications;
* Zollinger-Ellison syndrome, GC, Upper gastrointestinal bleeding, or Active peptic ulcer;
* Coexistence of significant concomitant illnesses, including heart disease, renal failure, hepatic disease, previous abdominal surgery, lactation, or pregnancy;
* Patients who had used probiotics, vonoprazan, and antibiotics in the past 12 weeks;
* Unwillingness to participate in this study.
The Caregiver's Burden in Cerebral Palsy

Cerebral palsy (CP) results from damage to the developing brain of the fetus or infant. These non-progressive lesions cause a set of permanent movement and posture disorders, responsible for activity limitations. These disorders are often accompanied by sensory, perceptual, cognitive impairments, communication and behavioral disorders, and sometimes epilepsy and/or secondary musculoskeletal problems. It is the leading cause of motor disability in childhood and affects 200 newborns per year in Belgium.

Cerebral palsy affects two to three people in every 1,000 of the world's population. The prevalence, incidence and most common causes have varied over time due to significant changes in obstetric care and pediatric care. In 75% of all cases of cerebral palsy, the lesions occurred before childbirth.

The population of adults diagnosed with cerebral palsy is increasing as the survival rate of children born with a disability increases. This population requires adapted and expert care services for the continuous monitoring and management of their condition. In addition, the development of additional health problems in adulthood increases the need for permanent access to care structures. Adults with CP have a higher rate of chronic health problems (ischemic heart disease) and a deterioration in their functional status. They would also have difficulty having a social and professional life which negatively impacts their quality of life.

A large number of adults with CP cannot access appropriate care or medico-social structures. This results in a significant involvement of caregivers (family environment or close entourage).

The role of caregiver is at the origin of a significant physical and psychological burden, whether for underage patients or adult patients. The study of this burden is well known in certain neurological pathologies (head trauma, multiple sclerosis, brain tumors). In the field of cerebral palsy, a study showed that the primary caregivers of children with CP had higher levels of psychological and physical disorders than the control group studied (caregivers of healthy children).

Currently, there are very few studies assessing the burden of caregivers of adults with cerebral palsy. The objective of this study is to analyze, through various specific questionnaires, the quality of life and the presence of depressive symptoms linked to the burden of caregivers of adults and children with cerebral palsy, taking into account socio-economic and environmental data.


Eligibility Criteria:
Inclusion Criteria:

- Healthy subjects, aged 18 to 75, caring for relatives of adults and children with cerebral palsy, with a good understanding of the French language.

Exclusion Criteria:

- Subjects under 18 or over 75, presenting a language barrier (interview guide written in French), subjects with a known history of psychiatric pathologies.
Investigation of Gait Pattern in Idiopathic Scoliosis

Scoliosis is a condition characterized by an abnormal curvature of the spine, which can affect an individual's gait. Scoliosis can alter body balance and weight distribution. Pedobarographic analysis identifies imbalances and abnormal pressure points by measuring the distribution of pressure applied to the sole of the foot. This examination helps detect abnormalities in the gait mechanics of individuals with scoliosis. Gait analysis can identify long-term foot and leg problems caused by scoliosis at an early stage, allowing for early interventions to prevent more serious issues.

The aim of this study is to analyze gait in individuals with idiopathic scoliosis and compare it with that of healthy individuals. The study will include 30 scoliosis patients who visited the Department of Orthopedics and Traumatology at Gazi University Hospital and were diagnosed with idiopathic scoliosis by a specialist physician. The gait patterns of the patients will be evaluated using pedobarography. Information about the type and degree of scoliosis will be obtained from hospital records. The results of this study may provide an objective and detailed evaluation of gait and pressure distribution disorders in individuals with scoliosis and may contribute to more effective treatment plans.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of idiopathic scoliosis by an orthopedist
* The Cobb angle measured on the standard scoliosis radiograph should fall within the range of 10°-45°.

Exclusion Criteria:

* Presence of any orthopedic or neurological disease affecting trunk and extremity mobility, excluding scoliosis.
* History of previous spine or orthopedic surgery.
EUS Guided Core Liver Biopsy and IGB Placement for the Diagnosis and Management of NASH and Obesity

This study is designed to investigate the impact of weight loss achieved with the IGB on NASH with early fibrosis in a select cohort of patients with obesity preselected to have a high pre-test probability of having NASH with early fibrosis based on magnetic resonance elastography (MRE)-Hepatogram. In addition, this study will explore potential non-invasive imaging criteria for NASH and early fibrosis using EUS-Elastography.


Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with Non-alcoholic Steatohepatitis with early evidence of fibrosis as seen on MRE-hepatogram
* Referred clinically for an intragastric balloon placement for weight loss

Exclusion Criteria:

* Women who are pregnant or plan to be pregnant or are breastfeeding
* Previous history of gastric surgery
* Current or recent (within 6 months) gastric or duodenal ulcers
* Gastroparesis
* Liver cirrhosis
* Coagulopathy or active use of coagulation
* Inability to provide a written informed consent