cyrilzakka/clinical-trials huggingface dataset:
Understanding the Measurement of Girdle Dissociation in the Fall of the Older People Subject.

Falls, especially in the older people, are frequent with potential serious consequences. The strategy for preventing falls involves detecting the fall risk. Current tests to determine the risk of falling are too late indicators of gait disorder. Loss of gait dissociation is an element associated with the mechanism of the fall and appears earlier. Its diagnosis is particularly important as it is a reversible impairment if rehabilitation interventions can be proposed to correct this anomaly.

The purpose of this study is to validate the device's measurement of belt dissociation in a discriminating manner between fallers and nonfallers.

Eligibility Criteria:
Inclusion Criteria:

* Informed and signed a written consent form.
* Affiliated or eligible to a health insurance system.
* Being able to give their consent to participate.
* For fallers: had at least one fall in the previous year.
* For non fallers: not had a fall in the previous year.

Exclusion Criteria:

* Patients suffering from a neurological or articular pathology responsible for gait disorders (Parkinson's disease, hemiplegia, narrow lumbar canal, peripheral neuropathy, vestibular pathology, chronic inflammatory rheumatism...).
* Patients who have undergone joint surgery of the lower limbs during the year.
* Patients walking with a walker.
* Patients with an internal electronic device (pacemaker, neurostimulator, insulin pump...).
* Patients taking long-term neuroleptics.
* Patients with advanced major cognitive impairment (according to the Clinical Dementia Rating Protocol \>1).
Asia Coma Electrical Stimulation (the ACES Trial)

This study is a prospective multicenter randomized controlled trial from Asian countries to compare the effect and safety of right median nerve stimulation versus traditional treatment for comatose patients at the early stage following traumatic brain injury.

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity and one of the greatest unmet needs in public health. The most severe injury can lead to a poor outcome and prolonged coma of the victims. It is estimated that ten to fifteen percent of the severe TBI patients are discharged in a prolonged coma or a vegetative state. However, no treatment measure to data has been proven robustly to alter the pace of recovery or improve neurological outcome of the comatose patients following TBI.

Although right median nerve electrical stimulation (RMNS) has been used clinically for more than two decades, no strong evidence of efficacy was generated because of the limitations in the past trials including a small sample size or the inappropriate study design. In the present study, a multicenter research network with inclusion of neurotrauma centers from China, India, Nepal and Kazakhstan was established with the aim to validate the efficacy and safety of a promising intervention strategy for traumatic coma at early stage. Since RMNS is a simple, inexpensive, noninvasive technique with a good safety profile, our study will probably add more evidence to the treatment of traumatic coma in Asian countries.

Eligibility Criteria:
Inclusion Criteria:

* A confirmed history of closed traumatic brain injury 10 days before enrollment
* A Glasgow coma scale (GCS) score of 4-8 or the motor part less than 5 if the patient received tracheotomy.
* 18-65 years of age

Exclusion Criteria:

* Unstable vital signs
* Have a history of severe cardiac arrhythmias, implanted pacemaker, as well as seizures
* Pregnancy
* No informed consent
Posterior Capsule Opacification (PCO) Evaluation of the AcrySof SN60AT Lens vs. SN60WF Lens

To assess posterior capsule opacification (PCO) in patients implanted with either the AcrySof SN60AT lens or the AcrySof SN60WF lens.


Eligibility Criteria:
Inclusion Criteria:

* patients with bilateral senile cataracts
* Age \> 50 years
* Fit for hospital follow ups
* Pupils dilating \> 6mm preoperatively
* Eyes expected to see 6/12 or better postoperatively

Exclusion Criteria:

* Diabetes
* On treatment for glaucoma
* Other ocular pathology
* Previous ocular surgery
Low Protein Diet, Gut Microbiome and Chronic Kidney Disease

Chronic kidney disease (CKD) is a worldwide public health dilemma because of close association with multiple comorbidities, demanding high cardiovascular events, mortality and expensive medical cost. Novel and effective therapeutic measures remain urgently needed to reduce burden and impact of disease. Advanced renal failure can profoundly alter the biochemical milieu of the gastrointestinal tract leading to a leak gut. Application of 16s rRNA gene analysis identified an increase of Clostridia, Actinobacteria, and Gammaproteobacteria in hemodialysis patients and decrease of Bifidobacterium and lactobacillus in peritoneal patients. This altered microbiome consequently affect production of indole or phenol derived uremic toxins leading to renal damage. Our preliminary results indicated reduced number and diversity of intestinal microbes CKD patients compared to normal. Different dietary nutrients can affect the gut microbiome and derive several deleterious metabolites leading to metabolic disarrangement. Clinically, low-protein diet should be prescribe to renal patients to preserve renal function and high fat content are usually recommended to avoid caloric malnutrition to dietary restriction. The changes of diet-microbiome-metabolite interaction are large unknown with this dietary manipulation. The aims of this study is to determine the renal progression-associated gene and taxonomic alterations bymetagenome-wide association studies and the functional characterization of gut microbiome in CKD patients receiving different low-protein or high-fat diets. The results of the study will provide insight on the exact role of dietary manipulation in CKD patients from gut-renal cross talk.


Eligibility Criteria:
Inclusion Criteria:

1. . Patients aged 30-90 years with diagnosis of CKD (defined as abovementioned).
2. . Sign the inform consent and agree to participate in this study.
3. . Compliant to low protein diet (defined as protein intake \<0.8 g/Kg/day) for 4 weeks assessed by 24h urine urea estimates, before enrollment

Exclusion Criteria:

1. . History of any malignancy, liver cirrhosis, intestinal operation, irritable bowel syndrome, cardiovascular disease (defined as myocardial infarction, documented Q wave on EKG, unstable angina, coronary artery disease with stenosis \> 75%, congestive heart failure with Ejection Fraction \< 50% and cerebrovascular disease) in the past 3 months.
2. . History of or infection disease requiring admission in the past 3 months or, concomitant antibiotics use.
3. . Concomitant use of probiotics or prebiotics.
4. . Pregnancy.
5. . Renal transplant recipients.
Efficacy of Neuromuscular Bandage Technique Against Jones Technique After the Supraespinatus Muscle Tendon Suture

The suture of the supraspinatus tendon is a common surgery that requires physical therapy for back pain and functional impairment to such surgery. Kinesiotaping technique (KT) is being used to treat myofascial trigger points that appear after surgery and for the treatment of physiotherapy in the supraspinatus muscle and deltoid.

To evaluate the effectiveness of KT technique over the technique of Jones (Straincounterstrain or SCS) in patients undergoing suture the tendon of the supraspinatus muscle.

Objective: To evaluate the effectiveness of the KT technique against Jones (Strain-Counterstrain or SCS) technique in patients with the suture of the tendon of the supraspinatus muscle.

Design: Test clinically controlled, randomized, masking of intervention by double placebo and blind to the subject of the essay and the Studio analyst.

METHOD: Patients with supraspinatus tendon suture are randomly divided into two groups: a group treated with KT (n = 18) and other treated with SCS (n = 18). The treatment was applied the 1st, 4th and 8th day of physical therapy session. All patients were evaluated the 1st and the 12th day of the session with the visual analog scale of pain (VAS), with the scale of Disabilities of the arm, shoulder and hand (DASH) to assess the functionality and active direction-finding (ROM) to assess travel articulate.

Eligibility Criteria:
Inclusion Criteria:

* Among patients attending the 1st and 5th week after Intervention.
* Patients with age above 18 years.
* Patients of both sexes.
* Patients with a detectable with algometer trigger point in the supraspinatus and / or deltoid .

Exclusion Criteria:

* Patient with Impaired Communication .
* Patients with signs of infection .
* Patients with previous surgery on the shoulder or shoulder capsulitis submit .
* Patient scammers cervical herniated discs or brachial neuropathy .
* Patients with tumor pathology.
* Patients with fibromyalgia,
* Pregnant patients.
* Patients with central pain .
* Patients conducted simultaneously treatments .
Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge

The study will assess the duration of protection of single doses of 2 different long acting muscarinic antagonists against methacholine induced bronchoconstriction.


Eligibility Criteria:
Inclusion Criteria:

* male or female asthmatics \> 19 years of age
* baseline methacholine PC20 less than or equal to 4mg/ml
* baseline lung function \>65% predicted
* non-smoker and less than 10 pack year smoking history

Exclusion Criteria:

* use of anticholinergic within 30 days of Visit 1
* poorly controlled asthma
* pregnant or nursing
* respiratory illness within 4 weeks of Visit 1
* exposure to an agent that triggered asthma worsening (e.g. allergen) within 4 weeks of Visit 1
Home Telemonitoring In Patients After Myocardial Infarction

This study is being done to determine if taking an electrocardiogram (ECG) by a portable device (SmartHeart) followed by a phone call will improve patient outcomes by early recognition of abnormalities and decrease emergency room visits and hospital readmissions compared to standard therapy alone.


Eligibility Criteria:
Inclusion Criteria:

* Acute myocardial infarction, both STEMI and non-STEMI.
* Able to use the home ECG telemonitoring.
* Must have smartphone device with home wi-fi/mobile internet which allows for 24/7 ability to transmit ECG.
* Caring family member who will be able to help/perform the ECG in case the patient won't be able to do it.

Exclusion Criteria:

* No ability to use the device at home/unable to comply with the device instructions
* No smartphone device or home wi-fi/mobile internet which prevent 24/7 ability to transmit ECG
* Cannot download the smartheart app
* No support in home environment
* Out of hospital cardiac arrest: secondary to a non-shockable rhythm, unrelated to an acute coronary syndrome, or with any level of neurologic damage.
* Resident of nursing home or acute care facility
* Uninterpretable ECG at discharge - left bundle branch block (LBBB), pacemaker or implantable cardioverter defibrillator (ICD) with pacing dependence.
* Patients who are planned for staged PCI after the index hospitalization
Adductor Canal Block Versus Liposomal Bupivacaine in TKA

This is a randomized prospective study of 60 patients undergoing total knee arthroplasty evaluating the clinical outcomes of liposomal bupivacaine periarticular injections (PAI) when compared to single shot adductor canal block using bupivacaine HCl.

Total knee arthroplasty(TKA) is an effective solution for end stage arthritis of the knee; however, post-surgical pain can be difficult to manage and the optimal peri-operative pain management strategy has not been established. This study serves to evaluate the clinical outcomes of liposomal bupivacaine PAI when compared to single shot adductor canal block using bupivacaine HCl in patients undergoing a TKA. The investigators hypothesized that peri-articular injection with liposomal bupivacaine would not be inferior to an adductor canal block using bupivacaine HCl. A total of 60 patients were recruited. Thirty patients were randomized to receive intraoperative liposomal bupivacaine periarticular injection, and another thirty patients randomized to receive a pre-operative adductor canal block using bupivacaine. Both groups otherwise received standard pain management strategies peri-operatively. The primary outcome of interest was post-operative pain, which was measured using the Visual Analog Scale (VAS). Secondary measures included changes in patient function which was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee range of motion, post-operative ambulation distance, and hospital length of stay.

Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing unilateral primary total knee arthroplasty for end stage osteoarthritis or rheumatoid arthritis.
2. All adults \> 18 years of age.

Exclusion Criteria:

1. Not cleared by PCP and appropriate specialists to undergo TKA (Check No if patient has been cleared.)
2. Adults undergoing bilateral primary total knee arthroplasties.
3. Women who are pregnant.
4. Women who are breastfeeding.
5. Inability to receive successful spinal anesthesia.
6. Allergy to amide anesthetics.
7. Inability to receive IV tranexamic acid.
8. Patients who are unable to speak English.
9. Patients who are less than 66kg.
10. Patients who are opioid dependent. We define opioid dependency as patients who are on a long-acting narcotic or patients who are taking more than six tablets of hydrocodone 5mg or equivalent.
The Effect of Laparoscopic Surgery on Ovarian Reserve According to Cyst Types

The aim of our study is to compare the effect of laparoscopic ovarian cystectomy on ovarian reserve in terms of different cyst types.

Participants who will be treated surgically for ovarian cysts will be included in the study. Anti-Mullerian Hormone (AMH) levels of the participants will be investigated before the surgery and 6 months after the surgery. All surgeries will be performed under general anesthesia laparoscopically. After histopathological evaluation, the participants will be divided into three groups; Group 1: Endometrioma, Group 2: Mature cystic teratoma (Dermoid cyst) and Group 3: Serous or mucinous cystadenoma.

A total of fifty-five women will be included in the study.

Eligibility Criteria:
Inclusion Criteria:

* no ovarian surgery before

Exclusion Criteria:

* Endocrinological pathologies
* Suspicion of malignancy in preoperative laboratory and ultrasonographic evaluations
* Detection of malignancy in histopathological examination
In-patient Study in Patients With Type 2 Diabetes Mellitus

This study is a placebo-controlled study in both healthy normal subjects and patients with Type 2 Diabetes Mellitus to assess the levels of exenatide in the bloodstream when it is given for 7 days, and to assess the impact this medication has on various substances in the blood. Assessments include repeat blood sampling and monitoring of any side effects.


Eligibility Criteria:
Inclusion Criteria:

* have type 2 diabetes mellitus that has been diagnosed for at least three months
* must be taking either (1) no medication for their diabetes or (2) taking metformin, a sulfonylurea, or metformin and a sulfonylurea
* must be willing to wash-out of these medications for 14 days prior to the start of the study
* must have bloodwork that meets certain criteria (for example, total cholesterol \< 240 mg/dL)

Exclusion Criteria:

* must not have any other major illness other than diabetes
Pharmacotherapy for Schizophrenic Drug Users - 6

The purpose of this study is to evaluate maintenance neuroleptics for Schizophrenic patients who are cocaine abusers.


Eligibility Criteria:
Please contact site for information.
Genicular Nerve Block Versus IPACK Block for Knee Arthroscopic Surgery

Postoperative pain management after knee arthroscopic surgery continues to evolve with better treatment strategies being formulated to improve patient satisfaction, and clinical outcomes and reduce opioid use in the immediate postoperative period. appropriate perioperative pain management has been shown to result in faster recovery and rehabilitation leading to better functional outcomes in patients undergoing knee arthroscopic surgery. this has necessitated the development of multimodal analgesics. peripheral nerve blockade has been reported to deliver optimal postoperative pain relief and is increasingly preferred in patients undergoing arthroscopic procedures and various different techniques such as sciatic nerve block, femoral nerve block, and genicular block have been described.

The genicular nerves include branches from the femoral, common peroneal, saphenous, tibial, and obturator nerves which innervate the knee capsule. the superolateral, superomedial, and inferomedial branches of the genicular nerve were reported to be in proximity to the periosteum of the tibia and femur, and the superolateral, inferolateral, superomedial, and inferomedial quadrant of the anterior knee joint were shown to be innervated by superior lateral, inferior lateral, superior medial and inferior medial branches of the genicular nerve, respectively alongside the branches of peroneal and femoral nerves Thus, a genicular nerve block specifically Targets these branches which innervate the knee joint for the management of postoperative pain in arthroscopic surgery.

On the other hand, the interspace between the popliteal artery and capsule of the knee(IPACK) block provides analgesia on the posterior knee joint, and the application of a genicular or IPACK block has been proven to be associated with promising outcomes following arthroscopic surgery

Eligibility Criteria:
Inclusion Criteria:

* age 20_60 years
* American Society of anthologist class I-III
* BMI18_35 kg/m2
* scheduled for primary unilateral knee arthroscopic surgery

Exclusion Criteria:

* known allergy to local anesthesia
* contraindication to local anesthesia injection (e.g., infection at the site of injection
* contraindication to spinal anesthesia (e.g., coagulopathy)
* patients with preexisting motor or sensory deficit in lower extremities
* insulin or non-insulin-dependent diabetes mellitus
* systemic corticosteroids use within 30 days
* history of arrhythmia or seizures
* severe renal insufficiency
* patient refusal
Multiple Ascending Dose Study of CTP-692 in Healthy Volunteers

This study will assess in healthy male and female subjects the safety and pharmacokinetic (PK) profiles of 3 dose levels of CTP-692 following 7 days of dosing.


Eligibility Criteria:
Inclusion Criteria:

* Healthy adult males and females between 18 and 55 years of age, inclusive
* Body weight ≥ 55 kg and body mass index within the range of 18 to 32 kg/m2, inclusive

Exclusion Criteria:

* Screening laboratory measurements outside the normal range associated with potential risk for the treatment under investigation at screening and/or prior to the first dose of study drug
* Positive blood screen for human immunodeficiency virus (HIV antibody), hepatitis B virus surface antigen or hepatitis C virus antibody
* History of clinically significant central nervous system (e.g., seizures), cardiac, pulmonary, metabolic, renal, hepatic or gastrointestinal (GI) conditions
* Positive drug or alcohol test at screening or prior to the first dose of study drug
Comparison Between the Imaging Consent Form and the Existing Narrative Consent Form

This is a single-center, randomized, double-blind clinical study to compare patient comprehension and anxiety by comparing a traditional paper consent form to a multimedia consent form for patients undergoing transforaminal epidural steroid injection.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older
* Patients undergoing lumbar transforaminal block for the first time
* Patients who are able to understand the contents of the video consent form and written consent form.

Exclusion Criteria:

* Patients who have difficulty understanding or answering consent forms
* Patients who have previously experienced a transforaminal steroid injection
Efficacy of Internet-delivered Strengths Use Intervention

The aim of the study will be to test the efficacy of a novel online-delivered gamification-based intervention for the identification, development, and use of strengths in the workplace. The program will be addressed to young employees and will have the aim of boosting their well-being and performance.


Eligibility Criteria:
Inclusion Criteria:

* Not other than the age of the participants.

Exclusion Criteria:

* Lack of internet access during the period of the implementation of the program (prescreened during enrolment).

Controlled variables:

* Participants levels of work engagement and work experience will be controlled for by stratified randomization. For each of the two factors we will created three strata (low level: lowest - 33rd percentile; moderate level: 34th - 66th percentile; high level: 67th percentile - highest), and the randomization will be applied for each stratum.
Post-marketing Surveillance (Special Use-results Surveillance) on Use With Liraglutide (Victoza®)

This trial is conducted in Asia. The aim of this trial is to evaluate safety and effectiveness of Victoza® in patients with type 2 diabetes mellitus (T2DM) in combination with antidiabetes agents other than sulfonylurea under post-marketing normal clinical practice conditions.


Eligibility Criteria:
Inclusion Criteria:

* Informed consent obtained before any study-related activities (Study-related activities are any procedure related to recording of data according to the protocol)
* Patients with T2DM (type 2 diabetes mellitus) who the physician has decided to start treatment with Victoza® in combination with insulin or OAD (oral anti-diabetes drug) other than SU (sulfonylurea)
* Male or female, no age limitation

Exclusion Criteria:

* Previous participation in this study or NN2211-3772 Participation is defined as informed consent obtained for this study or enrolment for NN2211-3772
* Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
* Patients who are on Victoza® or have previously been on Victoza® within 3 month before the enrolment
Digital Health Nudging in Adolescents With Congenital Heart Disease

In adolescents with congenital heart disease physical activity level is reduced which is why promotion to a more active lifestyle with an age-appropriate and modern intervention is needed. In healthy subjects digital health nudging was shown to increase physical activity. However, in adolescents with congenital heart disease such studies have not been conducted yet. In this RCT participants receive daily, short smartphone messages with the primary purpose to increase daily physical activity, which is monitored with a "Garmin vivofit jr." wearable.


Eligibility Criteria:
Inclusion Criteria:

* Adolescents aged 12 to 18 years inclusive
* Presence of a congenital heart defect (must be moderate or complex according to ACC criteria)
* Presence of written informed consent

Exclusion Criteria:

* Cognitive impairments that inhibit patients from understanding the tasks