cyrilzakka/clinical-trials huggingface dataset:
Light Therapy for Chronic Insomnia in General Practice

* Sleep disorders, especially insomnia
* Attention deficits (or disorders), daytime somnolence and drug dependence
* The goal is to evaluate whether light therapy could be used as an efficient alternative treatment with direct application in general practice

Insomnia affects 15 to 20% of the general French adult population and increases with age. General practitioners (GPs) are the first confronted to sleep disorders, especially insomnia.

Cognitive-behavioral therapies (CBT) have proven effective, but their implementation in everyday practice is limited, and alternative treatments are still needed.

Light not only has a great influence on the sleep-wake cycle and alertness, but also on mood and cognitive functions.

The administration time of light condition will be calculated for each individual in a modality that has no impact on the circadian phase.

Study will be conduct on an outpatient basis in general practice

Eligibility Criteria:
Inclusion Criteria:

* Complaining of chronic insomnia according to ICSD-3 (International Classification of Sleep Disorders) criteria and/or taking hypnotics at least 3 nights per week for more than 3 months.
* Non-hypnotic medication: stable medication during one month preceding the inclusion and for the 8 weeks of the study.
* Compliance with the treatment: the patient is able to have light therapy during the required time and at the agreed schedule.

Exclusion Criteria:

* Severe psychiatric disorder (severe major depression, schizophrenia, bipolar disorder), obvious acute psychiatric comorbidity.
* Untreated intrinsic sleep pathology: sleep apnea syndrome based on clinical criteria: STOP-BANG questionnaire score, restless legs syndrome manifesting more than 2 times a week and/or requiring treatment.
* Mild to severe dementia.
* Neurodegenerative sleep troubles
* Severe intercurrent pathology.
* Ophthalmic troubles presenting a contraindication to light therapy: retinopathy, age-related macular degeneration, diabetic retinopathy, macular hole, epiretinal membrane); lens opacifications (cataract) justifying surgery (correction of poor visual acuity, visual discomfort); glaucomatous and non-glaucomatous optic neuropathy resulting in visual impairement.
* Toxicomania, chronic alcoholism.
* Secondary insomnia linked to somatic non-stabilized pathology.
* Elements influencing circadian rhythm
* Pregnancy, breastfeeding.
* Participation in another interventional clinical trial which includes an exclusion period
* No information could be given to the patient (subject faces emergency situation, comprehension difficulties, etc.)
* Patient under guardianship
* Non hypnotic treatment potentially inducing a level 3 sleepiness one week before
Kinesiophobia in Postmenopausal Osteoporosis

This study aims to evaluate kinesiophobia levels in postmenopausal women with osteoporosis compared to a healthy control group and to explore the relationships between kinesiophobia and various psychosocial factors, including quality of life, fear of falling, and symptoms of depression and anxiety.

This cross-sectional, controlled study aims to explore kinesiophobia levels in postmenopausal women with osteoporosis compared to healthy age-matched controls. Postmenopausal osteoporosis is a systemic condition characterized by reduced bone mineral density, which increases fracture risk and can significantly affect individuals' physical activity and overall quality of life. Kinesiophobia, or the irrational fear of movement due to perceived injury risk, can further exacerbate this issue by restricting physical activity, which is vital for maintaining bone health. The study will involve 60 postmenopausal women diagnosed with osteoporosis and 60 healthy age-matched women without osteoporosis or osteopenia. Participants will be recruited from the outpatient clinics of İstanbul Physical Therapy and Rehabilitation Training and Research Hospital between January 21, 2024, and February 21, 2024. The study will assess kinesiophobia using the Turkish version of the Tampa Scale for Kinesiophobia (TSK), quality of life with the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41), and symptoms of depression and anxiety using the Hospital Anxiety and Depression Scale (HADS). Additionally, the Tinetti Falls Efficacy Scale (TFES) will evaluate fear of falling, and bone mineral density will be measured using dual-energy X-ray absorptiometry (DXA).

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis: Participants must be diagnosed with postmenopausal osteoporosis and have been under follow-up for at least six months.
* Age: Individuals must be 50 years or older.
* Health Status: Participants must have excluded secondary causes of osteoporosis.

Exclusion Criteria:

* Comorbid Conditions: Presence of other musculoskeletal, neurological, or psychiatric diseases that could influence kinesiophobia or pain.
* Cognitive or Communication Difficulties: Any cognitive dysfunction or communication issues that might impair the participant's ability to engage with the study.
* Acute Conditions: Presence of acute painful conditions that might affect the results.
* Medications: Use of medications or presence of diseases that could cause balance or functional disorders.
The Effect of Digital Storytelling on Nursing Students' Compliance

This study investigated the effect of digital storytelling on nursing students' compliance with isolation precautions and their knowledge levels.This was a pretest-posttest open-label randomized controlled trial. The nursing department of the faculty of health sciences of a university in the eastern Black Sea region of Turkey. The sample consisted of 109 fourth-year nursing students divided into groups of experimental (n=66) and control (n=43). Data were collected using a demographic characteristics questionnaire, an Isolation Knowledge Test (IKT), a Questionnaire of Students' Opinions on Digital storytelling (QSODS), and the Scale of Compliance with Isolation Precautions (SKIP). The experimental group attended a digital storytelling activity (intervention), while the control group received an education based on the curriculum. The data were analyzed using the Mann-Whitney U test, the Wilcoxon test, the Analysis of variance (ANOVA), and the Spearman correlation test.


Eligibility Criteria:
Inclusion Criteria:

* Being voluntary
* Having access to the Internet

Exclusion Criteria:

* Not attending the digital storytelling activity (intervention)
* Not taking the posttest
Comprehensive Awareness and Control in Diabetes Patients in China Jiangxi: A Cross-Sectional Survey

The study is a multicenter, sub-center contrast, cross-sectional survey.The primary objective of this study was to assess the Comprehensive Awareness and Control of blood glucose, blood pressure, and blood lipids among patients with type 2 diabetes in China Jiangxi. An additional objective was to investigate the impact of hospital type on clinical outcomes.

Background: With the continuous improvement of living standards in the past 30 years, the lifestyle and diet of Chinese people have undergone significant changes, leading to a significant increase in the prevalence of diabetes, hypertension and lipid metabolism disorders. Prevention and control work is also increasingly valued. At present, there is no research on the awareness rates and control rates of blood glucose, blood pressure and blood lipids in diabetic patients in Jiangxi Province. During the 13th Five-Year Plan period, the country has vigorously promoted the grading system of chronic non-communicable diseases, but there is a big gap between the levels of disease management in different levels of hospitals.

Methods:The province's multi-center, sub-center control, cross-sectional survey, the number of cases planned to be included in 10000 cases. Patient Access: Within 2 years from the date of the study (December 2016), eligible patients were screened out of outpatients in the participating hospitals, and patients were reviewed and informed of the informed consent.Inclusion criteria: in line with the WHO1999 diabetes diagnostic criteria; age 20-80 years; duration of 1 year or more; signed informed consent. Exclusion criteria: at the same time using other experimental drugs or in other clinical trials; gestational diabetes, other special types of diabetes; in acute infection, trauma and other stress conditions and the acute phase of the disease and other anomalies; patients with malignant tumors.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged 20 years to 80 years who were diagnosed with diabetes according to the World Health Organization criteria, at least 1 years before screening,written informed consent

Exclusion Criteria:

* Patients if they were pregnant or Other special types of diabetes, Patients with malignant tumor,participating in any other clinical studies, In phase of acute infection, trauma, such as stress state and acute phase of disease and other anomalies
Massage With Senna-based Laxatives Versus Senna-based Laxatives in Managing Overflow Retentive Stool Incontinence

This study aimed to evaluate the effect of abdominal massage with senna-based laxative in managing overflow retentive stool incontinence in pediatrics.

Much attention has been devoted to children with overflow retentive stool incontinence (ORSI) by the pediatric surgeons, as the referral of such cases from pediatric facilities is constantly increasing. An important initial step in managing these children is the exclusion of Hirschsprung's disease starting by water-soluble contrast enema.

Conservative management of ORIS is generally successful. The aim of the treatment is to achieve and maintain regular bowel movements free of symptoms Laxatives remain the mainstay of maintenance therapy of ORSI; yet, there is no standard laxative therapy despite the varieties of medication currently available. New information to these queries can be beneficial to medical staff involved in managing overflow retentive stool incontinence in pediatrics, Possibly it may add new guideline of treatment with more good result , short time and decrease the laxative dose.

Eligibility Criteria:
Inclusion Criteria:

* Pediatric patients with ORSI according to Rome III criteria
* Contrast enema suggestive of fecal loading
* the absence of anatomic, physiologic or pathologic reason for their constipation

Exclusion Criteria:

* radiological suspicion of Hirschsprung's disease,
* anorectal malformation,
* mechanical obstruction,
* failed to comply with the offered treatment (mainly if cramping abdominal pain or vomiting occurred),
* Required bowel surgery.
* spina bifida, spinal cord injury,
Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players

At this investigation we want to find out whether there is a difference in muscle strength of the internal and external rotation hip muscles between soccer players and non-soccer players caused by typical movement patterns seen in soccer sport.

Nontraumatic hip injuries are a problem often seen in Soccer Players. A biomechanical formation mechanism is probably. Little research has focused on the measurement of hip external and internal rotation strength at soccer players. The purpose of this study is to investigate the influence of soccer sports at the isometric force and force ratio of the hip rotator muscle system. Two samples of Athletes will be compared: Soccer Players (N15) and Non-soccer players (N15) matched in sex, age and level of physical activity to investigate hip rotator force in 3 different angles of hip flexion (0°/45°/90°). The measurement will be made with a handheld dynamometer.

Eligibility Criteria:
Inclusion criteria:

Study group:

Amateur footballers (N15) in the age between 18 and 35 At least five years of active footballer's career Football training twice weekly Active participation in play No pain or limitations in the area of the hip or the lower extremity

Control group:

Athletes (N15), non-soccer players with now asymmetric leg activities In the age between 18 and 35 At least twice weekly sports activity for at least 30 minutes No pain or limitations in the area of the hip or the lower extremity

Exclusion criteria:

Professions with asymmetric leg activities Pain or limitations in the area of the hip or the lower extremity Surgery on the hip in the prehistory
Novel Biomarker Assay for Biomarker Assay for HCC Detection

The primary purpose of this study is to assess the performance feasibility of Genetron's novel HCC liquid biopsy biomarkers assay for early detection. Piedmont Transplant Institute will provide a longitudinally collected blood sample from all HCC cases (mixture of early and advanced stage HCC) and cirrhosis control to Genetron Health after obtaining informed consent.

HCC is a leading cause of cancer-related deaths in the US. Early detection is crucial to improve the outcome of HCC. HCC surveillance is recommended for early detection of HCC in patients with cirrhosis. However, current HCC surveillance tests, such as liver ultrasound and AFP have relatively low accuracy for the detection of early-stage HCC. Genetron Health recently published on novel liquid biopsy biomarker for detection of HCC in China. The biomarker showed excellent performance for the detection of HCC among the at-risk population, most of whom had HBV infection. It is crucial to validate the performance of this novel biomarker in an independent population of patients with different etiology of liver disease outside of China. As this novel biomarker is useful in the detection of small HCC, it may also serve as an excellent biomarker for assessment of treatment response and monitoring of recurrence.

The primary purpose of this study is to assess the performance feasibility of Genetron's novel HCC liquid biopsy biomarkers assay for early detection. Piedmont Transplant Institute will provide a longitudinally collected blood sample from all HCC cases (mixture of early and advanced stage HCC) and cirrhosis control to Genetron Health after obtaining informed consent. Genetron Health will analyze the blood sample and provide data to the PI, for internal review purposes. Should the initial pilot study be successful, the parties will have a discussion to expand the number of cases and control samples and consider conducting a multicenter prospective study.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with HCC (based on histology or radiology according to AASLD guideline) or liver cirrhosis (based on the clinical history of hepatic encephalopathy, thrombocytopenia, radiologic features of the nodular liver, features of portal hypertension such as ascites, splenomegaly, or MR elastogram or fibroscan showing result consistent with cirrhosis)
* Willing and able to provide informed consent to participate in this study

Exclusion Criteria:

* Unable to provide blood samples
* Age less than 18 years of age
* Patient who have active cancers (excluding HCC) in the past five years, except for nonmelanoma skin cancer
Mother-to-child Transmission of HBV in China

In order to evaluate the feasibility of eliminating mother-to-child transmission (MTCT) of hepatitis B virus (HBV) by 2030, a multi-center, prospective cohorts study was conducted to investigate MTCT of HBV in China.

A prospective, multicenter study of pregnant women with HBV infection was conducted from July 2015 up to now in a real world setting in the Shield Project stage Ⅱ. Inclusion criteria was any pregnant women with chronic HBV infection. Pregnant women were excluded if they had a positive serologic test for human immunodeficiency virus or hepatitis C virus or any co-morbidity that might reduce compliance or if they were unable or unwilling to use the mobile health application-Shield APP. Enrolled mothers and infants were prospectively followed until infant post-vaccination serologic testing (PVST) was performed at 7-12 months of age.

Demographic data, antiviral treatment history, pregnancy and labour history, co-morbidity, HBV serologic marker tests, HBV DNA tests, liver function tests, mode of delivery, neonatal characteristics (height, weight, head circumference, Apgar score and any major birth defect), breastfeeding and PVST for infants at 7-12 months of age were collected.

A mobile health application called "SHIELD" was developed and used in the Shield Project stage Ⅱ to collect data and provide support for communication between mothers and their doctors. All laboratory test reports, questionnaires and other relevant information was uploaded into SHIELD. Participants could consult with their doctors via SHIELD during the follow-up.

Eligibility Criteria:
Inclusion Criteria:

* pregnant women with chronic HBV infection.

Exclusion Criteria:

* positive serologic test for human immunodeficiency virus or hepatitis C virus;
* any co-morbidity that might reduce compliance;
* unable or unwilling to use the mobile health application-Shield APP
Dexmedetomidine and Propofol in the Treatment of Emergence Agitation

1. This clinical research aims to compare the effects of dexmedetomidine and propofol on the treatment of emergence agitation in adult patients after general anesthesia.
2. Half of participants will receive dexmedetomidine while the other half will receive propofol when emergence agitation happens.

As a common problem observed in pediatric patients after sevoflurane anesthesia, emergence agitations are investigated mainly in children.For adults,previous studies were almost about the efficacy of premedication on preventing emergence agitation. Once emergence agitation happens, there is still no guidelines established to recommend the medication usage in the post-anaesthesia care unit.So high-quality prospective clinical studies are required to provide evidence for emergence agitation treatment.

Dexmedetomidine and propofol are both widely used in general anesthesia and can be acquired easily.When emergence agitation occurs,both injections are common choices in daily clinical administration on emergence agitation.To the investigator's knowledge ,propofol with a very quick onset is superior for anesthesia goals, but is without analgesia effects.While dexmedetomidine can produce sedation,analgesia,anxiolysis.So the investigators propose the hypothesis here that dexmedetomidine is prior to propofol on the treatment of emergence agitation in adults patients after general anesthesia.Therefore this research is undertaken to verify the hypothesis.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients aged 18-65 years old after general anesthesia
* with informed consent provided.

Exclusion Criteria:

* age younger than 18 years or older than 65 years;
* American Society of Anesthesiologists classification ≥Ⅲ;
* preoperative lung dysfunction(including pneumonia,atelectasis,adult respiratory distress syndrome,acute lung injury and so on);
* preoperative heart dysfunction(including sever cardiac coronary disease,unstable angina,LVEF≤30％，sick sinus syndrome，bradycardia:heart rate≤50bpm,second or third degree A-V block);
* history of mental disease;
* no informed consent provided;
* uncontrolled hypertension(baseline blood pressure:SBP≥160mmHg or DBP≥110mmHg);
* cancers;
* enrolled in other researches within 90 days;
* allergic to intervening medicine.
* BMI less than 18 or more than 30 kg/m2.
Comparison of Lung Administration With Three Different Nebulizer

Comparison between three modalities of nebulization.


Eligibility Criteria:
Inclusion Criteria:

* Healthy Subjects

Exclusion Criteria:

* Pulmonary disease
* Cardiac disease
Motor Intervention for Preschooler With Motor Coordination Deficits

This research project aims to examine the impact of motor coordination deficits and the effects of motor intervention on preschool-aged children's perceived competence, health-related physical fitness, activity participation and physical activity. Eighty children, aged 4-6 years,with or without motor coordination deficits will be recruited and assigned to to motor intervention (DCD-t), control 1 (DCD-c) or control 2 (TD) group. Children in the intervention group will receive motor intervention for 12 weeks. All children will be assessed at baseline, 0-, 3- and 6-month post-intervention.

This research project aims to examine the impact of motor coordination deficits on preschool-aged children's perceived competence, health-related physical fitness, activity participation and physical activity. Furthermore, the investigators are to investigate the effects of motor intervention on children's competence and participation during preschool age. This study plans to recruit 40 children with motor coordination deficits, aged 4-6 years, and 40 age- and gender-matched typically developing children. Children with motor coordination deficits will further be randomly assigned to motor intervention (DCD-t) or control (DCD-c) group. At baseline assessment, all children will be assessed for motor coordination competence, self-perception of competence, health-related physical fitness and daily activity participation. Physical activity will also be quantitatively measured using accelerometry. During the intervention phase, children in the DCD-t group will receive task-oriented motor intervention combined with fitness training three times per week while children in the DCD-c group remain usual activities. All children will be re-assessed at 0-, 3- and 6-month post-intervention. Repeated Measures ANOVA will be applied to examine the differences of motor competence, self-perception, fitness and activity participation among the 3 groups of children and over the 9-month period. The effects of motor intervention on DCD children's competence and participation will also be examined.

Eligibility Criteria:
Inclusion Criteria:

* aged 4 to 6 years
* motor coordination competence \< 15%ile comparing to norms for motor-deficit group or \> 30%ile for healthy group

Exclusion Criteria:

* genetic and chromosome deficits
* neurological or neuromuscular disorders
* congenital musculoskeletal disorders
* fracture in the past 6 months
* other conditions that affect the child's participation in physical activities
Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?

Treatment strategy of post endoscopic submucosal dissection (ESD) ulcer is not yet conclusive. Rebamipide is a mucosal protective agent widely used in East Asia and has good effect on quality of ulcer healing (QOUH). The investigators will conduct this randomized controlled study to assess the effect of a combination therapy of rebamipide and proton pump inhibitor (PPI) on post ESD ulcer healing.


Eligibility Criteria:
Inclusion Criteria:

* patients underwent ESD for gastric adenoma or cancer

Exclusion Criteria:

* subjects with previous gastric surgery
* subjects taking aspirin, anticoagulant, or antiplatelet agent
* subjects having malignancy except gastric cancer
* pregnant or breast-feeding women