cyrilzakka/clinical-trials huggingface dataset:
Rehabilitation of Partially Injured Hamstring Muscles

The aim of this study protocol is to describe the rationale and methodology for evaluating the effect of using therapeutic exercises and ultrasound in the rehabilitation of partially injured hamstring muscles on elite football players.

Hamstring muscle injuries are common among highly active individuals. Modern Football is a challenging sport characterized by extremely dynamic and cyclical game motions including numerous bouts of high-speed movements such as accelerating, jumping, and change in direction, all of which are carried out at a high level of physical and technical difficulty. The most common reason for hamstring muscle injury is high-performance intensity. In addition, neuromuscular fatigue, athlete aging, low muscle strength, and hamstring muscle flexibility are also risk factors for hamstring muscle injuries. On the other hand, the main causes of repetition injury to the same muscle are the presence of a previous injury, the size of the muscle tear and the lessening of the long head muscle bundles of the biceps femoris

Eligibility Criteria:
Inclusion criteria:

* Players from the eight clubs in the Iraqi Football League
* Partially strained hamstring muscle pain when training football or playing a match, identified as:

  a. Player reported sudden pain in hamstring muscle c. Without any additional ailment.
* Based on the clinical signs and symptoms, defined as:

  1. Localised pain when palpating of hamstring muscle
  2. Localised pain from at least one of the following activities: The Extender, The Diver, and The Glider.
* MRI-confirmed of partially injured hamstring
* Available for follow-up

Exclusion criteria:

* Players with other injuries apart from hamstring injuries
* Players with a recent six-month history of a verified or suspected hamstring injury in the same leg.
* injured players who are already taking part in another rehabilitation program
* General contraindications for MRI
COVID-19 Vaccine Hesitancy Among Nurses

The purpose of this study is to investigate the correlation of intention to receive COVID-19 vaccine, recommendation behavior, and 5C psychological antecedents among Nurses. The results can be used to assist suggestions in the health education provided by nurses on the topic of COVID-19 pneumonia and its vaccination. The purpose of the study is also wants to build a basis for future research and public support in vaccine decision-making, as well as to enhance the promotion of vaccine policy and enhance the resilience of the whole population during the pandemic ear.

A cross-sectional study based on convenience samples. The investigators recruit nurses and the general public to respond to structured self-filling electronic questionnaires by using an electronic data collection system. The questionnaires include demographic data and vaccine hesitancy questions in a total of 35 items. Convenience sampling was applied to estimate the sample size according to the number of nurses in each county. It is planned to collect a total of 4258 responses by the end of the study. The study instrument is the 5C psychological antecedents of vaccination, which includes Confidence, Complacency, Constraints, Calculation, and Collective Responsibility.

Eligibility Criteria:
\[Nurses\]

Inclusion Criteria:

* Male and female participants must be ≥ 20 years at the time of informed consent.
* Male and female participants have verification of registered nurse license.

Exclusion Criteria:

* Male and female participants be\>80 years at the time of informed consent.

\[General publics\]

Inclusion Criteria:

* Male and female participants must be ≥ 20 years at the time of informed consent.
* Male and female participants have reading abilities above the intermediate level.

Exclusion Criteria:

* Male and female participants be\>80 years at the time of informed consent.
Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine

Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as Dexmetedomidine (Dex), and magnesium.

The technique of the spermatic cord block was first described in the 1960s by Earle AS.Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as Dexmetedomidine (Dex), and magnesium.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged from 18 to 60 years.
* ASA I-II.
* Undergoing Testicular Sperm Extraction Surgery.
* BMI from 18.5 to 30 kg/m2

Exclusion Criteria:

* Patient refusal
* Contraindications to regional anesthesia (bleeding disorders e.g. INR\>1.5, PC\<70%, platelet count\<100 × 109, use of any anti-coagulants, local infection, etc.).
* Known allergy to local anesthetics.
* ASA III-IV.
* Patients aged less than 18 or more than 60.
* Body mass index \>35.
* Patients with difficulty in evaluating their level of pain.
A Study to Learn About How the Flu and COVID-19 Vaccines Act in Healthy People

The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together.

This study is seeking healthy participants aged 18 or older. All participants in this study will receive only 1 shot to their arm, either a flu or COVID vaccine, alone or mixed. Participants will take part in this study for about 6 months, and participants will need to visit the clinical study site at least 4 times.


Eligibility Criteria:
Inclusion criteria:

* Participants 18 years of age or older
* Healthy participants who are determined by medical history, physical examination (if clinically required), and clinical judgement of the investigator to be eligible for inclusion in the study

Exclusion criteria:

* Vaccination with any investigational or licensed influenza vaccine within 150 days of enrollment
* Vaccination with any investigational or licensed COVID 19 vaccine within 150 days of enrollment.
* Receipt of antiviral therapies for influenza (eg, Tamiflu) within 180 days prior to Day 1.

Refer to the study contact for further eligibility details
Exploring Potential Associations Between Rurality and Hopelessness in IHD Patients

Hopelessness is associated with 3.4 times increased risk of mortality or nonfatal myocardial infarction in patients with ischemic heart disease (IHD), independent of depression. Hopelessness has been identified in 27-52% of patients with IHD and can persist for up to 12 months after hospital discharge. Hopelessness, a negative outlook and sense of helplessness toward the future, can be a temporary response to an event (state) or a habitual outlook (trait). Hopelessness is associated with decreased physical functioning and lower physical activity (PA) levels in individuals with IHD. Low levels of PA independently contribute to increased death and adverse events in patients with IHD. Rates of PA in IHD patients continue to be unacceptably low in both hospital-based cardiac rehabilitation and home settings. Compounding this issue is often the symptom of hopelessness. The links among hopelessness, PA and mortality and morbidity for patients with IHD remain largely unknown, especially in rural and minority IHD patients. The purpose of this study is to delineate differences in hopelessness between urban and rural patients with IHD, as well as between racial minority, including Hispanic and Native American, and White patients with IHD. Potential mediation of urbanicity and race/ethnicity by social connectedness, a key variable in rural settings, will also be examined. A 6-month longitudinal study will be conducted at Sanford Heart Hospital and Avera Health in Sioux Falls, South Dakota. Hopelessness will be measured using the State-Trait Hopelessness Scale. The results of this study have potential to transform nursing practice by providing a better understanding of hopelessness in IHD patients and informing future exercise rehabilitation studies and interventions in rural and minority populations.


Eligibility Criteria:
Inclusion Criteria:

* Myocardial infarction or unstable angina or having undergone a percutaneous coronary intervention or coronary artery bypass surgery
* ≥ 18 years
* planned discharge home
* cognitive and physical ability to complete the study measures.

Exclusion Criteria:

* None
MDR-JuggerKnot Mini Soft Anchor in Maxillofacial TMJ

The objective of this retrospective consecutive series PMCF study is to collect data confirming safety, performance and clinical benefits of the JuggerKnot Mini Soft Anchor (implant and instrumentation) when used for soft tissue to bone fixation in the treatment of temporomandibular joint (TMJ) surgery. Safety, performance, and clinical benefits will be evaluated at the following time points: pre op, 6 weeks, 3 months and 1-year follow-up. JuggerKnot Mini has been on the market since November of 2011.

The primary objective is to confirm safety of the study products. This will be assessed by recording the incidence and frequency of revisions, complications, and adverse events. Relationship of the events to either implant or instrumentation should be specified.

The secondary objective is the assessment of performance and clinical benefits by analyzing recorded patient-reported clinical outcomes measures (PROMs).

Eligibility Criteria:
Inclusion Criteria:

* Implanted with one or more JuggerKnot Mini Soft Anchor(s) with either a 2-0 or 3-0 suture
* Must have undergone repair, repositioning or reattachment of soft tissues, ligament and tendons to the mandible is required for surgical stabilization of the TMJ articular disc

Exclusion Criteria:

* Local Infection.
* Patient conditions including blood supply limitations and insufficient quantity or quality off bone or soft tissue.
* Patients with mental or neurological conditions who are unwilling or incapable of following postoperative care instructions or patients who are otherwise unwilling or incapable of doing so.
* Foreign body sensitivity where material sensitivity is suspected.
* Off-label use.
* Sepsis.
* Patient is a prisoner.
* Patient is a known alcohol or drug abuser.
Implantation of Add on Lens for Age Related Macular Degeneration Patients With Low Vision

Age related macular degeneration (AMD) is the leading cause of vision loss in patients older than 55 years old. AMD can present as dry AMD or wet AMD. In most cases AMD affects both eyes although in many cases it's asymmetrical as far as severity. Some patients require low vision aids to continue their daily life tasks. In the past a few attempts were made to use low vision intraocular lenses with corrective glasses without enough success. In addition telescopic and prismatic lenses were also tried. The difficulties with these lenses included low field of vision, unsatisfactory magnification, complicated surgical technique and high complication rates.

Recently an add on lens was designed for the sulcus for implantation in pseudophakic AMD patients. The add on lens doubles the magnification of the central image dependent on the reading distance and the anatomy of the eye.

The lens is acrylic hydrophobic and designed for implantation in the sulcus either in pseudophakic patients or in addition to an intraocular lens implanted during a routine cataract surgery. The lens is 13 mm wide with 4 symmetric haptics. The lens has 1.5 mm central part of 10 diopters and the rest of the lens has no optical power.

Our purpose is to study implantation of the lenses in AMD patients to improve their reading ability and to improve their daily living.

Study design Prospective study on implantation of the add on lenses in AMD patients. The study was approved by Rabin medical center IRB.

Patients will be examined for best corrected visual acuity prior to the surgery at 6 meter and for reading at 40 and 15 cm. Improvement of the reading ability at 15 cm compared to 40 cm will predict the potential for vision improvement with the add on lens.

Before the surgery patients will have a full ophthalmological examination. Patients will have axial length and keratometry examination using the biometry. The lens will be implanted in surgery through a 2.2 mm clear cornea and will be injected and positioned in the sulcus.

Patients will be followed up at 1 day, 1 week, 4 weeks, 4 and 6 months following surgery. During follow up patients will undergo full ophthalmic exam and well as visual acuity both for distance and near.

Eligibility Criteria:
Inclusion Criteria:

* Pseudophakic patients with non-active AMD that complain on near distance reading with a distance visual acuity better than 6/60.

Exclusion Criteria:

* Exudative AMD with fluids, advanced glaucoma, advance visual field defects, aphakia, following complicated cataract surgery with PCIOL in the sulcus , phacodonesis, chronic uveitis, rubeosis iridis, central corneal opacity.
Ventilation Strategy Reduces Postoperative Atelectasis

Atelectasis is common during and after general anesthesia. The investigators hypothesized that a ventilation strategy with a combination of 1) continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) and 2) a reduced end-expiratory oxygen fraction (FETO2) before commencing mask ventilation with CPAP after extubation would reduce the area of postoperative atelectasis.

During general anesthesia, the combination of reduced functional residual capacity (FRC), high inspiratory oxygen fraction (FIO2), and airway closure are the main factors implicated in the atelectasis, shunt and shunt-like effects that account for the majority of the impaired oxygenation seen during general anesthesia.

Previous studies have shown that formation of atelectasis during preoxygenation and induction of anesthesia can be avoided by adding a continuous positive airway pressure (CPAP) followed by a positive end-expiratory pressure (PEEP).During emergence from anesthesia, high concentrations of oxygen predispose to atelectasis formation. Even a recruitment maneuver, followed by ventilation with 100% oxygen with a PEEP/CPAP of 10 cm H2O until extubation, failed to improve postoperative oxygenation compared with that achieved with zero end-expiratory pressure (ZEEP).This failure may have been caused by the presence of lung regions with high oxygen concentrations.

The investigators hypothesized that by inducing and discontinuing anesthesia during CPAP/PEEP and deliberately reducing FIO2 after extubation, postoperative atelectasis would be reduced compared with standard protocols. To test our hypothesis, the investigators studied 1) a control group with no CPAP/PEEP and a FIO2 of 1.0 while breathing spontaneously after extubation, and 2) an intervention group that was on CPAP/PEEP of 6 cmH2O from induction to extubation and that received an FIO2 of 1.0 until extubation and then an FIO2 of 0.3 via a facemask while on CPAP after extubation.

Eligibility Criteria:
Inclusion Criteria:

1. Adult patients up to 75 years of age.
2. American Society of Anesthesiologists (ASA) physical status class I-III.
3. Be able to climb two flight of stairs without stopping.
4. SpO2 of ≥ 94% when breathing air in the supine position.
5. A body mass index (BMI, weight in kilograms divided by the square of the height in meters) of \< 31.

Exclusion Criteria:

1. Patients with chronic obstructive pulmonary disease.
2. Smokers.
3. Ex smokers if smoked more than 5 pack years.
4. Overt heart failure
5. Known or predicted difficult intubation.
Exemestane in Combination With Fulvestrant in Postmenopausal Women With Hormone Sensitive Advanced Breast Cancer

The purpose of this trial is to evaluate time to progression in women with hormone responsive advanced breast cancer treated with a combination of exemestane and fulvestrant.


Eligibility Criteria:
Inclusion Criteria:

* Proven breast cancer
* Metastatic or locally advanced breast cancer
* Hormonally responsive disease defined as estrogen (ER) and/ or progesterone receptor (PR) positive (\>10% staining by immunohistochemistry)
* Postmenopausal status
* No more than 1 prior chemotherapy for stage IV metastatic breast cancer allowed
* ECOG (Eastern Cooperative Oncology Group) performance status 0-2
* Adequate organ function
* Exclusion Criteria:
* No prior Exemestane or Fulvestrant
* Uncontrolled intercurrent illness including but not limited to:

  * ongoing or active infection
  * symptomatic congestive heart failure
  * unstable angina pectoris
  * cardiac arrhythmia
  * myocardial infarction within the last 3 months
  * psychiatric illness/social situations that would limit compliance with study
* Lymphangitic pulmonary disease; carcinomatous meningitis, bone marrow only metastases; and a rising tumor marker without any other site of metastatic disease.
* Presence of bleeding diathesis or coagulopathy, patients requiring coumadin
Safety Of VIRACEPT® 625mg Administered To HIV-Infected Women During Pregnancy

This study is an evaluation of the safety of 625 mg formulation when administered to HIV-infected pregnant women from their second trimester through six weeks postpartum. The study will also evaluate the pharmacokinetics of VIRACEPT


Eligibility Criteria:
Inclusion Criteria:

* HIV infection
* Second trimester of pregnancy

Exclusion Criteria:

* Major current or prior history of obstetrical complications
* Serious current medical diseases
* Evidence of HIV virus resistance to antiretroviral agents
Comparison of the Tibiofemoral Rotational Alignment After Mobile and Fixed Bearing Total Knee Arthroplasty

The anatomic landmark for the anteroposterior (AP) axis of the proximal tibia and its variability was investigated in this study in order to determine whether a certain landmark could be employed as a reference axis for the proximal tibia after rotating platform mobile bearing (RP-MB) and fixed bearing (FB) total knee arthroplasties (TKAs).

Reference of tibial AP axis for implanting tibial component in total knee arthroplasty have not been concluded. This study can suggest appropriate method for alingning the tibial component to accurate tibial AP axis.

Eligibility Criteria:
Inclusion Criteria:

* Primary osteoarthritis

Exclusion Criteria:

* infection
* inflammatory arthritis
* reoperation
* severe deformity
Use of Traditional Curved Iris Scissors or the Wuennenberg Modified Curved Iris Scissors for Skin Surgery

Every year thousands of dermatologic surgery procedures are performed at the University of Missouri Department of Dermatology, including Mohs Micrographic Surgery (MMS), Excisions, and biopsies. Surgery is known to cause anxiety for patients and with these procedures performed under local anesthetic on awake patients', the sights, sounds, and smells experienced during the procedure can lead to an increase in their anxiety or affect their overall perception of the experience. From performing and assisting with dermatologic surgery the noise associated with the use of the traditional curved Iris scissors provokes an increase in patient awareness to the procedure resulting in increased anxiety, triggering of the vasovagal response, and expressions of annoyance by the patient. However, the modified curved Iris scissors make almost no noise. The Investigators hypothesize that if patients were given the comparative experience of both types of curved Iris scissors during dermatologic surgery, then they will choose the modified curved Iris scissors because the lack of noise will be perceived as more pleasant experience. Our objective is to perform a prospective, single blinded, randomized controlled trial to determine how the noise of traditional curved Iris scissors vs the silent Wuennenberg modified curved Iris scissors affects patients during dermatologic surgery.


Eligibility Criteria:
Inclusion Criteria:

* Adult (18 years or older)
* non-pregnant
* patients being treated with Mohs micrographic surgery or excision on the head and neck

Exclusion Criteria:

* Patients not meeting above inclusion criteria will be excluded.
Mean Platelet Volume and Its Relation to Risk Stratification of Myelodysplastic Syndromes

The myelodysplastic syndromes (MDS) are a group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, reduced bone marrow (BM) function, and a genetic instability with enhanced risk to transform to secondary acute myeloid leukemia, AML

The diagnosis of MDS is an effort that requires clinicians and pathologists to work together. A patient's life, livelihood and outlook can be profoundly affected by the terms used by the treating physician. The typical presentation is unexplained anemia, leukopenia and/or thrombocytopenia, in an older patients (median age ≥ 70 years). However, thrombocytosis may be associated with the 5q-deletion syndrome or in selected patients with refractory anemia with ringed sideroblasts syndrome . The white count may be elevated in MDS / myeloproliferative disorder overlap syndromes particularly in chronic myelomonocytic leukemia, CMML.

MDS remains among the most challenging of the myeloid neoplasms to diagnose and classify, particularly in cases in which the blast percentage is not increased in the peripheral blood or bone marrow. Diagnostic problems can arise when the clinical and laboratory findings suggest MDS, but the morphologic findings are inconclusive; when there is secondary dysplasia caused by nutritional deficiencies, medications, toxins, growth factor therapy, inflammation or infection; or when marrow hypocellularity or myelofibrosis obscures the underlying disease process .

The prognosis of MDS is determined by several factors. Revised International Prognostic Scoring System (IPSS-R) for MDS divides patients into very low, low, intermediate, high and very high risk groups. Five factors (the percentage of bone marrow myeloblasts, the diagnostic cytogenetics, the hemoglobin level, the platelet count and the absolute neutrophilic count) are used to generate a prognostic score .

Eligibility Criteria:
Inclusion Criteria:

* All patients diagnosed to have myelodysplastic syndromes

Exclusion Criteria:

* no