cyrilzakka/clinical-trials huggingface dataset:
Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure

This study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (Toprol-XL) on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.

The goal of the GENETIC-AF trial is to demonstrate the superiority of pharmacogenetically targeted bucindolol compared to metoprolol for the prevention of symptomatic atrial fibrillation or atrial flutter in a genotype-defined population with heart failure and/or reduced left ventricular ejection fraction at high risk of atrial fibrillation/atrial flutter recurrence.

Eligibility Criteria:
Key Inclusion Criteria:

* Must weigh at least 40 kg
* Possess the β1389 Arg/Arg genotype
* Left Ventricular Ejection Fraction (LVEF) \< 0.50 assessed within 12 months prior to Screening
* At least one episode of symptomatic paroxysmal or persistent AF within 180 days of Screening
* Clinically appropriate for electrical cardioversion (ECV) if AF/AFL is present after study drug initiation
* Receiving appropriate anticoagulation therapy prior to Randomization

Key Exclusion Criteria:

* NYHA Class IV symptoms at the time of Randomization
* Significant fluid overload at Randomization
* Permanent AF at Screening
* More than two previous ECV within 6 months of Randomization or if the most recent ECV failed to produce SR
* Presence of an LVAD, or likely to requirement LVAD placement within 6 months of Randomization
* History of a successful atrioventricular (AV) node ablation
* History of an AF/AFL ablation within 30 days of Randomization
* Evidence of an appropriate firing of an implanted cardioverter-defibrillator (ICD) device for ventricular tachycardia (VT) or ventricular fibrillation (VF) within 90 days of Randomization
The Effect of Mobile-based Education and Exercise Program Given to Patients With Total Knee Replacement Surgery

Total knee replacement (TDP) surgery is recognized as an effective surgical option for patients who develop moderate to severe osteoarthritis of the knee. Before, during and after TDP surgery, patients experience physical, psychological and social problems. After TDP surgery, patients may experience problems such as dependency and sleep problems in their daily living activities. Patients who have sleep problems, who cannot rest enough, become tired and experience anxiety as a result. It has been stated that the education given to the patients in the preoperative period reduces anxiety and analgesic needs and increases satisfaction. Progressive relaxation exercises in patients It has been shown to be effective in reducing symptoms such as anxiety, pain and fatigue. With the widespread use of mobile technologies, a rapid development is observed in mobile health applications and it is thought that its use in the field of health will provide great benefits to nursing services. This study is of the randomized controlled experimental type. During the application process, a mobile-based training and exercise program will be applied to the patients in the experimental group. As the education content, information about pre- and post-operative information and video-supported training content that will guide the patients with voice commands about the exercises that the patients will do before the surgery will be included in the mobile application. With the implementation of this program, continuity will be ensured by meeting the information needs of the patients before and after the surgery, and by performing progressive relaxation and knee exercises correctly and regularly. With the use of this mobile application, it is aimed to increase the physical functions of the patients by reducing the level of anxiety and fear of movement.


Eligibility Criteria:
Inclusion Criteria:

* Patients who were decided to undergo total knee replacement surgery with the diagnosis of osteoarthritis,
* Patients who will undergo elective surgery
* Patients who will undergo unilateral total knee replacement surgery for the first time
* Patients who can be communicated verbally
* Patients without any psychiatric disease
* Patients who use smartphones and agree to participate in the study

Exclusion Criteria:

* Patients under the age of 18
* Patients who have had previous total knee replacement surgery
* Patients who underwent total knee replacement with emergency surgery
* Patients who will undergo bilateral total knee replacement surgery
* Patients with a previous psychiatric diagnosis
* Patients with verbal communication disorders
Active Clearance Technology (ACT) Registry

The purpose of this study is to evaluate the effectiveness of the PleuraFlow® Active Clearance Technology™ (ACT) System in the management of blood evacuation after cardiac surgery.


Eligibility Criteria:
Inclusion Criteria:

1. Male or Female subjects 18 years of age or older who received a PleuraFlow System following heart surgery.
2. Patient undergoing cardiac surgery via sternotomy

Exclusion Criteria:

1. Robotic surgery
2. Any access via thoracotomy
3. Any condition deemed inappropriate for inclusion by the investigators.
4. Intolerance to implantable silicone materials.
Lyspro Insulin vs Regular Insulin in Cirrhotic Patients

OBJECTIVE: To compare lispro insulin and regular insulin in the glycemic control of patients with liver cirrhosis and type 2 diabetes subjects. METHODS: 108 patients with liver cirrhosis and type 2 diabetes were randomly treated with regular insulin or lispro. After 122 weeks a cross-over was carried out and patients followed-up for 122 weeks. Then, all patients received a standard breakfast of 145 kcal following 12 U.I. of regular insulin or lispro, and C-peptide and insulin serum levels were determined over 300 minutes.


Eligibility Criteria:
Inclusion Criteria:

* Insulin-treated diabetes mellitus and liver cirrhosis

Exclusion Criteria:

* Oral hypoglycemic agents treated diabetes mellitus
* Liver cancer
The Use of Short SMS Messaging With Type 2 Diabetes (T2DM)

Physical activity (PA) can play a vital and an independent role in type 2 diabetes (T2DM) management care. Health research studies have shown evidence that PA can improve glycaemic control and glucose levels. PA is first line of self-care management recommended to patients with T2DM and most patients fail to perform the regular PA. It is always important for health providers to find better methods in encouraging and incentivizing PA in T2DM patients. Mobile phone messaging-based interventions have been shown to strengthen the delivery of health information and self-care management programs.

Studies have employed this as a tool for promoting T2DM self-care management interventions such as physical activity, glucose monitoring, medication adherence and nutrition. Despite the increasing number of these interventions globally, the effectiveness of mobile phone messaging-based interventions in Saudi Arabia context remains inconclusive and inconsistent. There is limited research conducted in this region. Therefore, there is a need for more studies to show evidence to ascertain the effectiveness of using mobile phone messaging to promote PA in T2DM patients in the context of Saudi Arabia.

Eligibility Criteria:
Inclusion Criteria:

* Clinician diagnosis of T2DM.
* Over 18 years of age.
* Possession of a cell phone with text messaging capability.
* Ability to read and understand Arabic.

Exclusion Criteria:

* Treatment with insulin adjustment
* Unable to understand the study requirements or give informed consent.
* Visual impairment.
* Any diabetes-related complications such as neuropathy or retinopathy that preclude ability to increase PA.
* Clinician concern (physicians will be asked to confirm whether eligible participants can be medically capable of performing PA at the recommended level advised by National Institute for Health and Care Excellence (NICE, 2013).
Effectiveness of Educational Poster to Primary and Secondary Teachers Regarding Emergency Management of Dental Trauma

The poster is effective in improving the level of knowledge regarding dental trauma of primary and secondary schools teachers in Hong Kong.

A cluster randomized controlled trial was conducted in mid May 2011,to test the level of knowledge regarding dental trauma with two groups, the intervention group with posters and control group without posters. A questionnaire is used to test the level of knowledge.

A cluster randomized controlled trial was conducted in mid May 2011, Hong Kong where no educational campaign regarding dental trauma targeting on primary and secondary school teachers was implemented before.

Lists of Primary and secondary schools were requested from the Education Bereau. Schools were invited to join the study from 1.3.2011 and then randomized to the intervention group and the control group in the unit of school using computer generated numbers.

All teachers filled in the first questionnaire and send it back to the investigator in 1 week. 3 copies of the same educational poster were given to the intervention schools, these schools were requested to display them in 1. the medical room 2. staff common room and 3 anywhere that information was usually placed for the teachers. No poster was given to the control group. After 2 weeks, the posters were removed by the teacher in charge. The same questionnaire was filled in by all the teachers in both groups and sent back in 1 week. The data were processed to show whether the poster was effective to improve the knowledge of the teachers. The study was complied with Declaration of Helsinki and ICH GCP guidelines

Primary outcome measures the score of the questionnaire

Eligibility Criteria:
Inclusion Criteria:

* The targeted group of this study included teachers working in primary (US grade1-6) and secondary (US grade 7-12 plus 1 year) schools in Hong Kong, who can read Chinese or English.

Exclusion Criteria:

* cannot read English or Chinese
Validity and Reliability of Turkish Version Leg Activity Measure

Patient-filled scales minimize the burden of data collection for clinicians in a clinical setting.

Therefore, Leg activity measure, a new self-report measure of active and passive function in the leg, has been developed.

Leg activity measure consists of three parts. The first part includes passive functions, the second part includes active functions, and the third part includes the assessment of quality of life.

It is a valid and reliable test in adult neurological patients with lower extremity spasticity. It can be used in the evaluation of the active and passive functions of the results of the clinicians' interventions by making the cultural adaptation of the Turkish language and examining its validity and reliability. We think that it will be important to determine the limitations in activity, participation and daily living activities and to evaluate their reflections.

Spasticity is a common symptom resulting from stroke, brain trauma, and degenerative brain diseases. Spasticity, known as rate-dependent resistance to passive movement, prevents many activities of daily living. Lower extremity spasticity, on the other hand, hinders joint movements and complicates mobility, transfer and passive activities of caregivers.

Goals for the treatment of spasticity often focus on active function improvements in walking, standing, and moving from different sitting positions. However, improvements in passive function tasks and symptom management are often equally important to patients. Active function is the use of the limb to directly perform a task. Passive fonskyion is care of the affected extremity, usually performed by the person himself, but may require assistance from another person.

There is a need for instruments with demonstrable measurement properties that can reflect a clinically significant change in practice. Outcomes developed for treatments such as botulinum toxin and physical interventions for spasticity aimed at improving any aspect of functional performance (active and passive function) should ideally reflect real-life function as opposed to simply observed tasks in the clinical setting.

Leg activity measure filled by the patient consists of three parts. The first part includes passive functions, the second part includes active functions, and the third part includes the assessment of quality of life.

It is a valid and reliable test in adult neurological patients with lower extremity spasticity. It can be used in the evaluation of the active and passive functions of the results of the clinicians' interventions by making the cultural adaptation of the Turkish language and examining its validity and reliability.

Eligibility Criteria:
Inclusion Criteria:

* 1 or more spasticity in at least one muscle according to the Modified Ashworth Scale
* Be between the ages of 18-65
* Volunteering to participate in the study

Exclusion Criteria:

* Under 18 years old, over 65 years old
* History of trauma in the last 1 year
* Having alcohol and substance abuse
* Having a pregnancy
Anti Inflammatory Treatment of Hypertension

To investigate the anti-inflammatory effect of amlodipine and levamlodipine in the treatment of hypertension

A total of 200 inpatients or outpatients in the Department of cardiovascular medicine of the third people's Hospital of Mianyang City from April 2021 to October 2021, who met the diagnostic criteria of ish2020 international hypertension practice guidelines, were selected and randomly divided into control group and experimental group, with 100 cases in each group. The control group was treated with amlodipine and the experimental group was treated with levoamlodipine. The changes of blood pressure and serum inflammatory factors were observed before and after treatment.

Eligibility Criteria:
Inclusion Criteria:

* ① In line with the diagnostic criteria of ISH2020 International Guidelines for Practice of Hypertension ② Age \>18 years old, gender is not limited, during the treatment did not take other drugs that will affect blood pressure: such as antidepressants, oral contraceptives, Chinese herbal medicine, etc.; Voluntary participation and signing of informed consent, and can complete all the visit plan.

Exclusion Criteria:

* (1) Those who do not want to take blood tests; (2) Left ventricular ejection fraction \< 50%, heart rate \<50 beats/min; ③ Acute coronary syndrome (unstable angina pectoris and myocardial infarction); ④ valvular heart disease, congenital heart disease, etc.; Other infectious diseases and malignant tumors; ⑥ Bronchial asthma; ⑦ Abnormal liver function and renal dysfunction (ALT BBB 0 80U/L, CR BBB 1 442mmol/L); Autoimmune diseases or any serious and fatal diseases; ⑨ Receiving lipid-lowering therapy and oral vitamins or antioxidants; They are mentally ill, have no self-awareness, and are unable to express themselves or cooperate with others.
Short Term Efficacy of High-intensity Laser Therapy in Patients With Knee Osteoarthritis

Knee osteoarthritis (KOA) is one of the most common health problems around the world. According to this, several interventions have been used to treat this group of patients including pharmacological and non-pharmacological management such as weight reduction, behavior modification, and physical therapy. Recently, high-intensity laser therapy (HILT) has been used to treat patients with KOA. The results of previous studies showed that HILT could help to reduce pain as well as improved function in patients with mild to moderate KOA. However, there were still no standardized guidelines for HILT treatment in KOA. Also, no previous studies evaluated the efficacy of HILT in patients with severe KOA. The present study, therefore, recruited not only mild to a moderate degree but also severe degree. The study aim was to determine the efficacy of HILT in terms of pain relief in patients with mild, moderate, and severe KOA. The hypothesis was HILT would effectively reduce pain in patients with KOA compared to sham laser plus conservative treatment.

* This study is a double-blinded randomized control trial that compared the efficacy of HPLT to sham laser in patients with KOA.
* 42 patients who had KOA diagnosed by the American college of rheumatology (ACR) 2016 guidelines were recruited including a drop out of 20%.
* The participants were then randomly allocated into two groups (21 participants per group), mainly HILT and sham laser. Also, both groups received conservative treatment such as disease education, exercise, and advice for weight reduction.
* The intervention group received HILT which was applied on the medial, lateral, and posterior part of the knee joint. The total energy was 562.5 J per session which was done 2-3 sessions a week, for a total of 10 sessions.
* The control group received sham laser by the same device for 10 sessions plus conservative treatment as in the intervention group.
* The outcome measures, VAS and T-WOMAC score were recorded before and at the end of the study.
* Statistical analysis was performed using SPSS 18.0 version to evaluate the statistically significant change within the same group and the difference between groups.

Eligibility Criteria:
Inclusion Criteria:

* Patients with primary knee OA diagnosed based on the American college of rheumatology (ACR) guidelines for early diagnosis of knee osteoarthritis 2016.
* Patients who had knee pain for at least 6 months and had VAS score greater than 4 out of 10 points
* Patients with knee OA who have Kellgren And Lawrence (KL) classification stages 2-4.

Exclusion Criteria:

* Patients who have secondary knee OA caused by other pathologies
* Patients who have a history of corticosteroid or hyaluronate injecting into the knee joint within the past 6 months
* Patients who were treated by physical therapy equipment within 1 month before the study
* History of stroke, bleeding disorders, cancer, deep vein thrombosis, cognitive impairment, or mental disorders
* Contraindicate to laser therapy
Diclofenac for Submassive PE

The primary objective is to demonstrate the clinical benefits of diclofenac (added to standard anticoagulant therapy) over placebo in normotensive patients with acute symptomatic pulmonary embolism and right ventricular dysfunction.

The secondary objective is to assess the safety after administration of diclofenac in normotensive patients with acute symptomatic pulmonary embolism and right ventricular dysfunction.


Eligibility Criteria:
Inclusion Criteria:

1. Acute symptomatic PE confirmed by multidetector CT angiography, a high-probability V/Q scan, or by the presence of deep vein thrombosis confirmed by lower limb ultrasound testing in patients with nonconclusive V/Q scan;
2. first symptoms occurring ten days or less before randomization;
3. haemodynamic stability (systolic blood pressure \> 100 mm Hg, no need of inotropic support, pulmonary resuscitation, intubation or thrombolytic treatment);
4. right ventricular dysfunction assessed by transthoracic echocardiography within the first 12 hours after diagnosis of PE;
5. signed informed consent.

Exclusion Criteria:

1. Previous diagnosis of chronic thromboembolic pulmonary hypertension;
2. active bleeding, or clinically relevant bleeding in the previous month before diagnosis of PE;
3. peptic ulcer;
4. major surgery, or severe trauma in the previous month before diagnosis of PE;
5. indication for chronic anticoagulation;
6. pregnancy or breast feeding;
7. renal insufficiency (serum creatinine \> 2 mg/dL) or severe hepatic impairment;
8. hypersensitivity to diclofenac, sodium metabisulfite, or acetylsalicylic acid;
9. bronchial asthma;
10. severe congestive heart failure;
11. inflammatory bowel disease.
Hip Posterolateral Complex Strengthening in Patients With Chronic Nonspecific Low Back Pain: a Randomized Clinical Trial

Chronic nonspecific low back pain is an important health condition with a high prevalence worldwide and it is associated with enormous direct and indirect costs to the society. Clinical practice guidelines show that many interventions are available to treat patients with chronic low back pain, but the vast majority of these interventions have a modest effect in reducing pain and disability. A biomechanical approach that has been raised is that a weakness of the hip abductors, extensors, and lateral rotators musculature (posterolateral complex - PLC) would lead to excessive contralateral pelvic drop during weight-bearing activities such as walking, running, climbing up or downstairs, generating an overload in the lumbar area. Although the strengthening of the hip PLC is largely used in clinical practice for treating patients with hip and knee injuries, there is still a lack of evidence regarding patients with low back pain. Therefore, questions remain about the efficacy of the hip dynamic stabilization as an additional intervention to conventional treatment in a well design trial with statistic power.

Randomised clinical trial will be held in following the recommendations of the CONSORT (Consolidated Standards of Reporting Trials). Will be recruited participants of both genders, aged between 18 and 60 years, with and without chronic nonspecific low back pain for over 3 months without irradiation for lower limbs. Potential participants with chronic nonspecific low back pain will be referred by their doctors orthopedic surgeons and/or rheumatologists that will make all the assessments and routine exams, for example, Imaging tests, prescription drugs and referral to physical therapy care. The characteristics of participants will be collected through an evaluation form specially designed for this study. This assessment form will contain issues related to demographic and anthropometric data, plus information about the clinical picture of the participants, as for example the use of medications, physical activity level, educational level, prior history of back pain and duration of symptoms.The clinical outcomes will be obtained at the completion of treatment (6 weeks) and at 3, 6, and 12 months after randomization.

The data will be collected by a blinded assessor. The statistical analysis will follow the intention-to-treat principles.

Eligibility Criteria:
Inclusion Criteria:

* • Will be included 70 patients of both sexes, adults with medical diagnosis divided into two groups: Group A consisted of 35 patients use receive conventional physical therapy plus the addition of hip PLC strengthening and group B consisted of 35 patients also only use conventional physical therapy

Exclusion Criteria:

* Will be excluded from the study patients who have neurological or osteoarticular disease preventing the ambulation of these individuals.