cyrilzakka/clinical-trials huggingface dataset:
SlagSens (Effect of Tactile Stimulation After Stroke)

The purpose of this study is to determine whether tactile stimulation for reduced sensibility of the affected extremities after stroke has effect.

Hypothesis:

Stimulation of sensibility after stroke will have a significant contribution for improved sensibility. Without any stimulation, no signal is sent to the brain and there is no need for the healthy parts of the brain to adapt this function. Stimulation of the sensibility over a period of time on both sides of the body, gives the brain signals and the opportunity to compare how the signals should be recognized. New connection will be able to interpret signals correctly.

Through stroke rehabilitation, function from damaged areas can be replaced by healthy parts of the brain. It is important for rehabilitation to take advantage of this compensatory qualities whit early intervention and mobilization. Only small gains can lead to big improvements.

About half of stroke survivors gets reduced sensibility caused bye the stroke, and sensibility is considered to be an important part of rehabilitation of function and activities.

A Norwegian guideline concludes that the scientific knowledge is to week to recommend this kind of treatment. There is some evidence for improvement of sensibility when specific training and stimulation is given. Achievements in sensibility can lead to some improvement in function.

The project will be carried out as a randomized controlled trial. In this project, the intervention group receive tactile senses stimulated twice daily over a period of 3 months, while the control group receives standard treatment. The results from both groups are measured before and after treatment.

Eligibility Criteria:
Inclusion Criteria:

* Patients with impaired tactile sensitivity after stroke Kongsberg hospital to undergo rehabilitation course.

Exclusion Criteria:

* Patients with a history of stroke.
* Patients with significant symptomatic additional diseases, such as neuropathy.
* Patients who cannot provide adequate response if they can feel the touch.
* Terminal and palliative care patients.
* Patients with cancer.
* Patients with hypertonic muscles in the current body area.
* Patients below 18 years of age
Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR)

The primary objective of this study is to determine whether impaired glucose tolerance is improved to a greater degree by Tarka than Hyzaar in subjects with metabolic syndrome


Eligibility Criteria:
Inclusion Criteria:

* Metabolic syndrome
* Fasting blood glucose between 100 mg/dL and 125 mg/dL
* Hypertension
* One additional criteria, Exclusion 1

Exclusion Criteria:

* Subject has a current diagnosis of Type 1 or Type 2 diabetes mellitus.
* Subject has a hypersensitivity to ACE inhibitor, ARB, CCB, clonidine, methyldopa, hydralazine, or thiazide diuretic medication.
Clinical and Molecular Aspects of Early Osteoarthritis

The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis. To our knowledge, there are no large-scale genetic studies on people with early osteoarthritis. The investigators therefore sought to study the causes of monogenic osteoarthritis in people suffering from early non-syndromic osteoarthritis.

Material and method From 2013 to 2019, experts in constitutional bone disease sent patients with non-syndromic early osteoarthritis for genetic analysis to our center of competence for constitutional bone diseases. The sequencing of a panel of genes was carried out by NGS.


Eligibility Criteria:
Inclusion Criteria:

- Patients with early osteoarthritis who have undergone genetic sequencing

Exclusion Criteria:

- Patients refusing to participate in research
Evaluation of the Efficiency of the Chronic Pain Management Training Program

The research will be conducted to evaluate the effectiveness of the web-based chronic pain management training program developed for nursing students. It is planned in a randomized controlled triple-blind design with the final year nursing students of the Nursing Department of Çankırı Karatekin University in a pre-test-post-test order.


Eligibility Criteria:
Inclusion Criteria:

* Nursing Grade 4
* with internet access
* Students who volunteered to participate in the research

Exclusion Criteria:

* Having a diagnosed psychiatric disorder
* Difficulty in understanding and speaking Turkish
* Graduated from Health Vocational High School
* Attending any training on pain and/or having a pain education certificate
Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery

the aim of this prospective randomized blinded clinical study will be to assess the ultrasound evaluation of different preventive measures of post operative lung atelectasis in abdominal surgeries; these measures include ventilation and fluid measures

ultrasound evaluation for application of different preventive measures of post operative lung atelectasis, including positive end-expiratory pressure, lung recruitment maneuvers, and restrictive fluid management.

Eligibility Criteria:
Inclusion Criteria:

* ASA physical status I or II, of either gender.
* BMI \< 40
* Age 30-60 years
* scheduled for elective abdominal surgeries

Exclusion Criteria:

* Patient refusal
* American Society of Anesthesiologists (ASA) physical status classification system more than II
* BMI \> 40 .
* Psychiatric disorders
* History of chest disorders such as asthma and obstructive pulmonary disease (COPD).
* History of Previous Thoracic Procedures.
* Pregnancy
The Clinical Application and Mechanism of Music Therapy (Mozart's Effect) on Epilepsy

Music has a long history in healing physical and mental illness. The Mozart effect was initially reported by Rauscher, Shaw, and Ky in the journal of "Nature" in the year of 1993. They examined performance on Stanford-Binet spatial tasks immediately following either 10 minutes of listening to Mozart's sonata K.448, silence, or instruction to relax. They found the performance scores were 9 point higher in Mozart-listening group than other two groups. Later, the beneficial influence of Mozart music on parkinson's disease, epilepsy, senile dementia, and attention-deficit/hyperactivity disorder was reported. However, the real neurophysiological mechanism of the influence remains unclear.

Epilepsy is a common disorder in the field of pediatric neurology. Although we had greatly advanced in develop of new anticonvulsant, thirty percent of patients with epilepsy have drug-resistance, which is associated with an increased risk of debilitating psychosocial consequences. In addition, the adverse effects of anticonvulsants are not uncommon. Few reports demonstrated that patients exposed to Mozart's music can significantly decrease in seizure frequencies and interictal epileptiform discharge. However, the case number of these studies was limited and the mechanisms of music therapy on epilepsy were not well known. In our recent studies, Mozart's music indeed decreased the epileptifrom discharge in the patients with epilepsy, particularly in the patients with generalized discharge and central discharge. On the basis of these encouraging results, we will try to investigate the neural mechanisms and clinical applications of music therapy in the following three years.

In the first year of our study, we use animal model to examine the possible mechanism of Mozart's effect. The aim of the second year study is investigation the effect of music on the cortical functions in the epileptic rat model. According to our previous study, Mozart's sonata K.448 was effective in reducing epileptiform discharge. On the basis of previous two-year results, the patients with epilepsy will be enrolled in the third year project to perform an individualized music therapy. In this study, we can provide an alternative therapy in the patients of epilepsy and investigate the possible biological mechanism of music effect.

Children with first unprovoked seizure were investigated.Patients were randomly classified into treatment and control groups. They did not receive AED after their first unprovoked seizure. The treatment group listened to Mozart K.448 for eight minutes once daily before bedtime for at least six months.All of the patients received follow-up telephone calls monthly. Patients who experienced seizure recurrence were advised to begin AED treatment.

Eligibility Criteria:
Inclusion Criteria:

* children who had epileptiform discharges with first unprovoked seizure

Exclusion Criteria:

* epileptic children without epileptiform discharges
Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation

The objective of this prospective observational single center study is to investigate donor-derived cell-free DNA (ddcfDNA), peripheral blood platelet mRNA, peripheral blood extracellular vesicle mRNA, and peripheral blood leukocyte mRNA expression in recognition of clinically significant endomyocardial biopsy (EMB) proven acute rejection in human heart transplant recipients. In detail, the objective is to develop novel biomarkers and liquid biopsies for diagnosis, prognosis, and targeted molecular therapy for primary graft failure, ischemia-reperfusion injury, acute rejection, and development of late graft failure and cardiac allograft vasculopathy, and for monitoring immunosuppression after heart transplantation.


Eligibility Criteria:
Inclusion Criteria:

* patient age \> 18 years
* heart transplant recipient
* has signed informed consent

Exclusion Criteria:

* foreign residency
* no signed informed consent collected
Validity Reliability of FrailBESTest in Older Adults

Fraility; It is an age-related biological syndrome. It is characterized by decreased resistance to stressors due to changes in functional reserves and physiological systems.

BESTest, which is frequently used in the literature, was modified and Frail'BESTest was developed to detect balance problems in fragile individuals. The test consists of 6 subtitles. These are participation, reaction, movement ability, sensory organization, biomechanical constraints, gait symmetry. When looking at the literature, the Turkish version of Frail'BESTest has not been found. For this reason, the aim of study is to examine the validity and reliability of the Turkish version of Frail'BESTest in elderly individuals and to question the effectiveness of its clinical use and to bring it to the use of other researchers.

Fraility; It is an age-related biological syndrome. It is characterized by decreased resistance to stressors due to changes in functional reserves and physiological systems.Especially, the increase in the incidence of falls, loss of mobility, dependence in basic life activities, increase in hospitalizations and increased incidence of death make the diagnosis and treatment of frailty important in elderly individuals.

BESTest, which is frequently used in the literature, was modified and Frail'BESTest was developed to detect balance problems in fragile individuals. The test consists of 6 subtitles. These are participation, reaction, movement ability, sensory organization, biomechanical constraints, gait symmetry. When looking at the literature, the Turkish version of Frail'BESTest has not been found. For this reason, the aim of study is to examine the validity and reliability of the Turkish version of Frail'BESTest in elderly individuals and to question the effectiveness of its clinical use and to bring it to the use of other researchers.

Eligibility Criteria:
Inclusion Criteria:

* Individuals aged 65 and over,

  * Your willingness to participate in research Elderly individuals with a diagnosis of frailty
  * No cooperation and communication problems

Exclusion Criteria:

* Individuals with neurological and orthopedic problems Uncontrollable hypertension

  * Those with cardiac disease
  * Those with cooperation and communication problems
The Repeatability of the Effect of Caffeine Supplementation on Submaximal Physiological Responses and Cycling Time Trial Performance

Recently, Grgic (2018) discussed the concept of responders and non-responders to caffeine supplementation highlighting the importance of the repeatability of results. However, the number of studies that have investigated this idea by repeating the same time-trial performance test multiple times with the same caffeine dose is sparse (Astorino et al., 2012; Del Coso et al., 2019). Furthermore, studies have shown that differences in the CYP1A2 genotype may account for some of the variation in time-trial performance (Guest et al., 2018). Thus, the current study aims to identify whether the effects of moderate caffeine supplementation (5 mg/kg) on time-trial performance are repeatable to aid the identification of responders and non-responders. Additionally, the study aims to determine if the CYP1A2 genotype may explain any of the variability in time-trial performance in trained male cyclists.


Eligibility Criteria:
Inclusion Criteria:

* To be considered for inclusion in the study, participants must be regular cyclists, between 18 and 35 years of age, capable of completing a 20 km cycling time trial at a minimum speed of 30 km/h (arbitrary inclusion criteria to ensure a sufficient standard of athlete).

Exclusion Criteria:

-
Study of Dietary Phosphate and Mineral Homeostasis in Early Chronic Kidney Disease

This study is designed to describe the physiological response to increased and decreased dietary phosphate intake on various parameters of mineral metabolism in the blood and urine of individuals with Chronic Kidney Disease stage 3 and 4 with normal serum phosphate levels. This detailed study will give us a far greater understanding of the role of diet in abnormal mineral homeostasis early in the progression of this chronic disease. The findings of this study will help both physicians and dietitians better determine the optimal time to introduce dietary therapy in CKD.

The potential benefits of implementation of phosphate management earlier in CKD (Stages 3/4) are threefold: 1) prevention of vascular damage early in the progression of CKD thus reducing risk of cardiovascular death 2) Improved management of renal bone disease and resultant co-morbidities and 3) slowing the progression of renal failure lengthening the time required till dialysis is required. Although dietary counseling is currently a normal part of CKD care, the utility and effectiveness of lowering phosphate has not previously been quantified. In part this is due to the difficulty of measurement of serum phosphate as it is so tightly controlled before GFR falls below 30mls/min. No studies have investigated whether is it possible to modulate circulating FGF-23 and phosphate excretion in early stages of renal failure using diet in individuals with normal serum phosphate levels.

Study Objectives ;

1. To measure FGF-23 levels before and after a high phosphate diet, low phosphate diet and a low phosphate diet with phosphate binders.
2. To measure levels of calcium, phosphate, PTH, 25 and 1,25 vitamin D and fractional phosphate excretion before and after a high phosphate diet, low phosphate diet and a low phosphate diet with phosphate binders.

Eligibility Criteria:
Inclusion Criteria:

* CKD patients with CKD stage 3 and 4 (eGFR \< 60 ml/min and \> 15 ml/min per 1.73 m2, not requiring dialysis).
* Normal serum phosphate stable over three months (\> 0.87 mmol/L and \< 1.70 mmol/L)
* Not yet following a low phosphate diet as reported by the patient or the renal dietitian (\<1500mg/d)
* Over 19 years of age

Exclusion Criteria:

* Body mass index \<20 kg/m2
* Current use of phosphate binders or active vitamin D or phenytonin (which induces vitamin D catabolism)
* Primary parathyroid defects
* Diagnosed osteoporosis
* Gut absorption defects
* Liver disease
* Pregnancy or lactation
* Patients hospitalised within the last 4 weeks
Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

The investigators are looking at the effect of humidified nasal high-flow with oxygen (HNHF-O2) on air exchange during exacerbations of COPD. HNHF-O2 therapy may have beneficial effects in patients with severe breathing impairment that results in low oxygen in the blood. Some studies show that patients with low blood oxygen levels who use HFNC oxygen have lower rates of needing mechanical ventilation.

Patients admitted to the hospital with an exacerbation of COPD accompanied by respiratory failure need supplemental oxygen and alleviation of an increased work of breathing. Patients with acute exacerbations of COPD have hypoxemia, hypercapnia and an elevated work of breathing due to increased airways obstruction and hyperinflation. Patient outcomes can be improved by aggressive bronchodilation and systemic corticosteroids, but methods that can augment spontaneous ventilation and decrease the work of breathing can help avoid intubation. High flow nasal cannula (HFNC) has been shown to be useful in patients with severe hypoxemic respiratory failure and those recently extubated from mechanical ventilation. HFNC provides warmed and humidified high flow (10-60L/min) by nasal cannula that allows precise titration of % inspired FiO2 in the air/oxygen blend. The AIRVO 2 device delivers warmed and humidified respiratory gases to spontaneously breathing patients using a humidifier and integrated flow generator. In this study, the air/ oxygen gas blend (20-35L/min) will be administered by the AIRVO 2 HNHF device to achieve an fraction of inspired oxygen (FiO2) \> 90% at rest. A potential advantage of the AIRVO 2 HNHF device includes the ability of the device to deliver oxygen that has been warmed and humidified. Also, the high flow rates achieved with this device may reduce the work of breathing. This is an open-labeled pilot study of ten patients to determine the safety and feasibility of using the device in the management of patients with an acute exacerbation of COPD with acute on chronic respiratory failure.

Eligibility Criteria:
Inclusion Criteria:

* Males and females 40 years of age or older
* Hospitalized for an acute exacerbation of COPD on the 6th floor of Rock Pavilion (pulmonary inpatient service)
* Smoking history of \> 10 pack-years
* PaCO2 ≥ 45 mm Hg
* Able to provide informed consent
* Willing to participate in daily measurements of arterial blood gases, completion of study questionnaires, and other study-related procedures

Exclusion Criteria:

* Upper airway or nasal problems that prohibit the use of humidified high-flow nasal oxygen
* Hemodynamic instability defined as the need for blood pressure or blood volume support to maintain adequate tissue perfusion and oxygenation
* Urgent need for endotracheal intubation
* A do-not-intubate order
* A known diagnosis of obstructive sleep apnea
* Present use of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BIPAP) therapy
Improving Safety of Antivenom in People Bitten by Snakes

A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, \& hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in people bitten by snakes: randomised, double blind, placebo-controlled trial.


Eligibility Criteria:
Inclusion Criteria:

* Above 12 years of age
* Patients admitted to hospital after snake bite in whom antivenom is indicated
* Patients who give informed consent

Exclusion Criteria:

* Patients who are pregnant or nursing
* Patients who are currently taking beta- or alpha-adrenoceptor antagonists, or tricyclic antidepressants
* Patients in whom adrenaline may be contraindicated (this may include patients with the following: history of ischaemic heart disease, stroke, uncontrolled hypertension, and tachyarrhythmias)
Assessment of Cholangio-pancreatoscopy for the Diagnosis and the Treatment of Biliary and Pancreatic Diseases

The biliary and pancreatic tumors are rare but the prognosis is pejorative. It was difficult to have histology of these tumors as the samples taken during ERCP were performed under " blind " radiology control. So the diagnostic accuracy was insufficient.

The arrival of A new optic fiber endoscope used by only one operator had improved the diagnostic of bilio-pancreatic diseases. However this technology with optic fiber quickly had proved outdated for several reasons: poor manoeuvrability, perfectible optical vision, optical fibers fragility and cost.

A new generation of endoscopes with digital vision appeared and would allow an increase in diagnostic accuracy related to better vision and manoeuvrability.

The purpose of the study is to assess the interest of the cholangio pancreatoscopy performed with digital vision.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged ≥ 18 years
* Patients with biliary duct stenosis with undetermined etiology
* Patients with pancreatic duct stenosis with undetermined etiology
* Patients with pancreatic duct distension with undetermined etiology
* Patients with biliary or pancreatic gallstones after failure to endoscopic treatment

Exclusion Criteria:

* Patients with haemorrhagic disease or hemostasis and coagulation disorders (TP \< 60%, TCA\> 40 sec. and platelets \< 60000/mm3).
* Patients treated with anticoagulant or platelet aggregation inhibiting drugs that could not be temporarily interrupted.
* Patients with biliary duct diameter \< 3 mm
* Patients with pancreatic duct diameter \<3 mm
N Acetyl Cysteine for Cystinosis Patients

This study intends to verify the interference of N acetyl cysteine in the progression of chronic kidney disease in patients with Nephropathic Cystinosis.

Patients with Nephropathic Cystinosis have an increased oxidative stress and go to end-stage renal disease, even when all steps of the treatment are done. Therefore, this study is conducted to verify the interference of the stress oxidative in the progression of the renal disease with the use of an oxidant drug, N acetyl cysteine (NAC). The investigators selected patients with good compliance of the treatment. In these patients the investigators evaluate the serum creatinine, creatinine clearance estimated by Schwartz Formula, cystatin C and a marker of oxidative stress, TBARS ( thiobarbituric acid substances). The variables are analyzed 6 months before the introduction of NAC and the three months after NAC.

Eligibility Criteria:
Inclusion Criteria:

* cystinosis patients age under 18 years with good compliance to the treatment with Chronic Kidney Disease 1 to 4 according to KDOQI

Exclusion Criteria:

* patients with CKD stage 5