cyrilzakka/clinical-trials huggingface dataset:
Using Superimposition of Intra-Oral Scan and CBCT in Single Implant Restorations in Aesthetic Zone.

This study will be performed to evaluate patients'satisfaction and aesthetic outcomes of single implant restorations in aesthetic zone by using superimposition of intra-oral scan and CBCT.

The accurate transfer of an ideal implant position from virtual planning to the actual implant site is essential for protecting vital structures as well as optimizing esthetic and functional outcomes.With the introduction of 3D imaging and implant planning software, preoperative design for a "prosthesis-driven" implant position becomes a reality.

The initial stage is digital image acquisition, which can be from extra-oral means such as cone beam computed tomography (CBCT) and laboratory scanners, or intraoral means such as intraoral scanners.

Image fusion or superimposition of the STL data obtained from the optical scanning, with the DICOM data obtained from the CBCT, is performed by matching the common reference points prior to implant planning.

The superimposed images enable virtual implant planning, while taking the surrounding anatomic structures and future prosthetic needs into consideration.

To conduct the present study, the following will be used:

1. DICOM file of CBCT for examination of single implant in aesthetic zone.
2. STL file of optical scanning for examination of single implant in aesthetic zone.
3. An implant planning software.
4. One type of dental implant.

Eligibility Criteria:
Inclusion Criteria:

1. At least 1 tooth having missed within 3-4 months or to be extracted in anterior zone, and the remaining teeth are adequate to support the surgical template.
2. Sufficient bone tissue to insert an implant without any need for augmentation (the residual bone height ≥ 10 mm, the buccolingual width ≥ 7 mm, and the labial bone plate is complete without bone dehiscence and fenestration).
3. Good treatment compliance.

Exclusion Criteria:

1. Presence of uncontrolled systemic diseases, infection, or inflammation around the implant sites.
2. Pregnancy or lactation.
3. Poor oral hygiene habits.
4. Psychiatric problems, alcohol, tobacco (\>10 cigarettes per day) or drug abuse.
5. Severe bruxism or clenching.
6. Not able to complete the follow-up.
Using Emails and Personalized Phone Calls to Increase Affordable Care Act Marketplace Enrollment Among Households Losing Medicaid

Since its passage in 2010, the Affordable Care Act (ACA) has helped reduce the uninsured rate to record lows, but changes in insurance coverage over time, known as churn, remain a concern. A recent survey found that nearly 25 percent of respondents reported a change in coverage over the previous twelve months. Among the most common reasons for churn is the loss of Medicaid eligibility, placing low-income populations at risk of a coverage gap. To date, little evidence exists on effective strategies states can use to facilitate Medicaid to Marketplace coverage transitions, an issue that has become more pressing amid projections that upwards of 15 million people could lose Medicaid eligibility once the COVID-19 public health emergency expires.

To address this gap and to inform Marketplace administrators, during a Special Enrollment Period (SEP) in 2017 in California's ACA Marketplace, we conducted a randomized controlled trial to examine the effect of email reminders, personalized telephone outreach, as well as the combination of the two forms of outreach on ACA enrollment among households who recently lost Medicaid and became eligible for subsidized Marketplace coverage.

During the SEP at the end of August 2017, the investigators randomly assigned households to one of four arms based on the last digit of their household identifier: a control group assigned to receive no outreach beyond an initial eligibility determination notice; an email-only group assigned to receive an initial eligibility determination plus email reminders about signing up for marketplace coverage; a phone-only group assigned to receive an initial eligibility determination plus a phone call offering enrollment assistance from a service center representative (SCR); a phone + email group assigned to receive an initial eligibility determination, email reminders about signing up for marketplace coverage and a phone call offering enrollment assistance.


Eligibility Criteria:
Inclusion Criteria:

* Those who recently lost Medicaid eligibility and became eligible for subsidized Affordable Care Act coverage

Exclusion Criteria:

* Those who recently lost Medicaid eligibility and were found ineligible for subsidies.
Construction of Theoretical Model of Medical Treatment Behavior of Patients With Chronic Kidney Disease

The impact of narrative nursing interventions on negative emotions, self-efficacy, quality of life in individuals undergoing maintenance hemodialysis

The objective of this study is to create a narrative nursing protocol using the "two-line system" approach to enhance the practice of narrative nursing.Investigators applied this protocol during maintenance hemodialysis (MHD) treatment, with the aim of examining the impact of the interventions on negative emotions, self-efficacy, and overall quality of life of patients. By analyzing the data before and after the interventions, investigators aim to demonstrate how targeted narrative nursing measures can positively influence negative emotions, self-efficacy, and life quality of patients.

Eligibility Criteria:
Inclusion criteria:

* Patients diagnosed with ESRD and treated with dialysis for more than 3 months;
* Patients aged ≥18 years old;
* Patients with complete clinical data;
* Patients who are clearly conscious and can accurately express their willingness;
* Patients who have signed informed consent and are willing to cooperate with the study.

Exclusion criteria:

* Patients with other serious systemic diseases, such as severe cardiovascular and cerebrovascular diseases, severe diabetes, etc.;
* Patients with mental disorder, such as cognitive or intellectual disability;
* Patients with a history of anxiety and depression;
* Patients with intermittent loss of consciousness or are unable to understand the questions in the questionnaire.
Healthcare Disparities in Alopecia Areata

Alopecia areata (AA) is a common immune-mediated non-scarring alopecia often associated with substantial morbidity. There are however, limited population-based data on potential disparities in the burden of AA, including across people of different ethnicities and deprivation.

We aimed to provide the first large-scale, population-based estimate of lifetime risk of AA overall and by important sociodemographic subgroups. As AA is associated with an increased burden of mental health conditions and work-related outcomes (unemployment, time off work), a detailed understanding of the burden of disease in different sociodemographic groups is vital to plan resource provision.

The overall purpose of the study is to provide an estimate of the cumulative lifetime incidence of AA in the population overall and by important sociodemographic groups. Moreover, to do a subgroup analysis in the AA population to identify health-related disparities across people in different socioeconomic strata, geographical distribution, sex and ethnic groups. The disparities that will be considered are AA associated: Mental health conditions; healthcare utilisation; and work impact (time off work and unemployment).

The cumulative lifetime risk of AA was estimated at age 80 years (approximate life expectancy in the UK) using survival models, with age as the timescale and accounting for the competing risk of death.

The assessment of any associations with baseline characteristics and the outcomes of interest will be assessed using Cox proportional hazards models (time to event outcomes) and Poisson regression (repeated event outcomes) models.

Eligibility Criteria:
Inclusion Criteria:

* Patients aged greater than 12 over the study period.
* Registered with the contributing primary care practice for any duration during the study period

Exclusion Criteria:

* People diagnosed with AA before the study period.
DIStinguishing ChildrEn at Low Risk of Severe infectioN in Case of Febrile Neutropenia-7: Impact Study of a Clinical Decision Rule

Febrile neutropenia (NF) is the leading cause of unscheduled hospitalization in children with cancer. Management classically involves emergency admission to hospital for intravenous antibiotic treatment until resolution of fever and neutropenia. However, children with NF are a heterogeneous group with varying risks of severe infection (10-29%). This approach, which is recognized as excessive for low-risk episodes of severe infection, particularly in terms of quality of life and cost, is no longer recommended. Management should move to a more personalized model that takes into account the individual probability of severe infection. Clinical decision rules (CDRs) have been proposed to facilitate risk stratification, but none are useful in our French population because of insufficient reproducibility or effectiveness.


Eligibility Criteria:
Inclusion Criteria:

* Followed for hemopathy or cancer,
* Presenting with post-chemotherapy NF,
* With social security coverage,
* With parents able to provide appropriate home supervision,
* Consent of parents and child if able to give consent.

Exclusion Criteria:

* NF to diagnosis of tumor disease,
* Child with palliative care,
* Child who has had an allogeneic hematopoietic stem cell transplant within the past year,
* NF immediately following an autologous hematopoietic stem cell transplant,
* Participation in the study during a previous NF,
* Curative antibiotic therapy or documented infection prior to admission,
* Initial management at a non-investigative center,
* Refusal of the child or parents to participate

Translated with www.DeepL.com/Translator (free version)
Progestin-Only Pill Use and Breastfeeding Study

This study will assess the impact of early initiation (less than one week postpartum) and delayed initiation (4 weeks postpartum) of two types of progestin-only contraceptive pills (POPs) on maternal, breastmilk, and infant outcomes.

This is a placebo-controlled randomized controlled trial enrolling dyads of birthing people and their newborn infants. We will explore if the type and timing of initiation of pills is acceptable to the user with minimal side effects, impacts the supply or composition of breastmilk, and/or affects infant growth.

Birthing people will be randomly assigned to 1 of 3 groups and will be blinded to group assignment:

1. immediate initiation of drospirenone-containing progestin-only pills (d-POPs),
2. immediate initiation of norethindrone-containing progestin-only pills (n-POPs)
3. immediate initiation of a placebo pill for one month followed by d-POPs.

Eligibility Criteria:
Inclusion Criteria:

* 18 years of age and older
* Desires to use POPs for 3 months
* Speak English or Spanish
* Had a vaginal or cesarean delivery of a singleton full term (≥37 weeks) infant less than 168 hours prior
* Intends to breastfeed exclusively for 6 months

Exclusion Criteria:

* Desire another pregnancy in less than 6 months
* Do not intend to exclusively breastfeed
* Do not have access to a telephone
* Have any medical contraindication to POPs
* Have any contraindication to breastfeeding, including maternal illegal drug use, history of augmentation or reduction, infant with major congenital anomaly
* Cognitively impaired
* Currently incarcerated
Point of Care Ultrasound for PICC Line Monitoring Study

A prospective comparative study evaluating chest x-ray determination of PICC line tip location and POC ultrasound PICC line tip location. NICU patient's with PICC lines will be enrolled and blinded ultrasound operators will scan the neonate to find the PICC tip location. This will be compared to the location on the patient's chest x-ray. This process will be repeated each time the patient has a chest x-ray.

Point of care (POC) ultrasound has become an invaluable tool for critically ill children. Several studies have been completed detailing its use for central line access and determining the location of the tip of umbilical venous lines. There are no current studies on monitoring PICC line tip placement using POC ultrasound. There have been studies showing ultrasound can be used to locate PICC line tip location, but none for monitoring. A previous study found that the sensitivity and specificity of US in identifying the location of PICC line tip were 86% and 75% respectively.

Review of the literature notes that Costa et al also found a high rate of PICC line complications. Costa et al and the investigators local experience also highlight the rare but potentially fatal complication of pericardial effusion from PICC lines that are too deep in the heart. One way the investigators could improve the safety of neonatal PICC lines is monitor them more closely. Current standard of care is to monitor PICC line tips on chest x-ray. Unfortunately, there is strong evidence that chest x-ray does not accurately identify the PICC line tip location. Another way would be to use POC ultrasound. A literature review on POC ultrasound to determine the location of a PICC line tip revealed that no such study has been done. Several studies have been completed demonstrating POC ultrasound both improved success rate and time to confirmation of placement of PICC lines.3 Pulickal et al published data on teaching pediatric residents to do point of care ultrasound to determine the location of the UVC tip. The investigators in that study found the residents were not only better at determining the correct location than chest x-ray, but the procedure was well tolerated. The investigators for this study feel further evaluation of POC ultrasound for PICC line tip monitoring to determine feasibility and accuracy is needed.

Eligible patients will be identified by the NICU care team. Participants will then be consented for the study by the study team. Trained Neonatology Fellows/Attendings will perform POC ultrasound to identify and document the PICC tip location and will be blinded to the PICC line tip location on x-ray. Ultrasounds will only be performed during patient's care times and be limited to 15 minutes.

Eligibility Criteria:
Inclusion Criteria:

* NICU patient at Seattle Childrens Hospital or University of Washington
* Patient has a PICC line in place

Exclusion Criteria:

* vertebral anomalies
* anomalies of venous anatomy
* tracheal anomalies.
The Effects of Low-dose Atropine and Orthokeratology in Pediatric Myopia Control

Both orthokeratology and atropine eye drops are effective methods for myopia control, but few studies have compared them all together simultaneously. Therefore, the primary aim of the present study was to compare the effect of orthokeratology versus low-dose (0.01% and 0.02%) atropine on the control of myopia progression.


Eligibility Criteria:
Inclusion Criteria:

Best corrected visual acuity less then 0.00 log MAR (minimum angle of resolution) units Cycloplegic SER of - 1.0 D or less in both eyes. An inter-eye cycloplegic SER difference of 1.00 D or more.

Exclusion Criteria:

Children with cycloplegic cylinder refraction of more than + 1.00 D or less than - 1.00 D.

History of binocular vision problems, including strabismus. History of known ocular disorders, including media opacities, macular dysgenesis, optic nerve hypoplasia, perinatal brain injury, buphthalmos, and retinopathy of prematurity.

History of medication use that might have affected the refractive results. Systemic or developmental problems that might have hindered refractive development.
Cocoa Ileostomy Study

There is substantial interest in the potential role of chocolate and its primary bioactive component; flavan-3-ol, (-)-epicatechin, in both the prevention and management of cardiovascular disease (CVD). Numerous observational studies have found the association between high cocoa intake and a reduced CVD risk and mortality, yet the impact of these mechanisms in vivo is unclear. In order to have a beneficial effect, these cocoa flavan-3-ols must be absorbed in the body in a forms, while still maintaining its advantageous characteristics. Consumption studies with ileostomists who have had their colon removed,provide information regarding the bioavailability and bioactivity of (-)-epicatechin and flavan-3-ols from cocoa, therefore the aim of this study is to determine the impact of methylaxanthines (including theobromine) on bioavailability of cocoa flavan-3-ols prior to entering the colon.

This study has a randomised double blinded crossover control design, being applied to ileostomy patients who are aged 18-65 years, N=10, 5 per group. The study is divided into two phases. During the first phase, subjects will partake in a 2-day restriction diet (No phenolic foods) and an overnight fast prior to sampling. Ileal fluid (0hr) is obtained from participants. They will then be asked to consume the cocoa flavanol beverage dissolved in 310g 1% milk. After this urine and ieal fluid is collected every 4 hours at 3 more time points and blood every hour at 8 time points. A 24 hr urine and ieal fluid sample is collected the following day. There will be a 1-week wash out period between each phase. Procedure is repeated again for phase 2.


Eligibility Criteria:
Inclusion Criteria:

* Undergone an ileostomy and be more than 1.5-years post-operative
* Male or female
* Aged between 18-65 years
* Non-smoking
* Not lactose/milk/dairy intolerant

Exclusion Criteria:

* Has not undergone an ileostomy and/or is less than 1.5 year post-operative
* Pregnant/ lactating females
* Smokers
* Lactose/milk/diary intolerant
The HIT-TRAP Trial

Randomised, double blind trial in non-intensive care trauma patients comparing unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) in heparin-induced thrombocytopenia (HIT).

This is a randomised, double blind trial including trauma patients with need for thrombosis prophylaxis with heparin. Patients receive either unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH).

Heparin-induced thrombocytopenia (HIT) antibodies are measured on days 1 and 10. There are daily platelet counts. On discharge an ultrasound doppler of the lower extremities is performed to rule out deep vein thrombosis (DVT).

Three months after discharge every patient is answering a questionnaire about thromboembolic complications following discharge.

The key questions of the study are whether the two heparins cause HIT-antibodies in differing frequencies, and if yes, whether these differences lead to different clinical outcomes.

Eligibility Criteria:
Inclusion Criteria:

* trauma-surgical patient
* consent given
* minimum age 18
* expected inpatient period at least 7 days
* need for thrombosis prophylaxis with heparin

Exclusion Criteria:

* intolerance of one of the study drugs
* malignancy with life expectancy \< 3 months
* pregnancy/lactation
* drug or alcohol abuse
* fibrinolytic therapy
* need for extracorporal circulation (e.g. cardiopulm. bypass, hemodialysis) at study entry
* participation in another clinical trial within 30 days prior to intended inclusion
Multicenter Phase III Trial of Laparoscopic Sentinel Node Biopsy

Laparoscopic sentinel lymph node biopsy and stomach preserving surgery in early gastric cancer is less invasive method which can increase quality of life. For last two years, multicenter quality control study (Phase II) has been performed in Korea and tolerable results were observed. Based on these results, multicenter phase III trial is required to validate the clinical role of laparoscopic sentinel lymph node biopsy.

The final analyses include the modified intention to treatment analysis (full analysis set) and Per Protocol analysis (including patients who underwent assigned surgery without agreement withdrawal).

1. Injection of tracer and sentinel basin dissection

   * Tracer: Tc 99m HSA (Human serum albumin, 2ml, 0.1mCi/ml) + ICG (indocyanine green, 2ml, 5mg/ml)
   * Endoscopic injection of tracer on 4 sites around gastric cancer
   * Identification of sentinel basin using laparoscopic probe (Neoprobe)
   * Laparoscopic sentinel basin dissection and identification of sentinel node at back table
2. Surgical considerations

   * If positive sentinel nodes were diagnosed in frozen section, conventional gastrectomy is performed.
   * If micrometastasis or isolate tumor cells in sentinel basin lymph nodes were diagnosed in the permanent pathology, re-operation of conventional gastrectomy is not performed.
   * However, re-operation of converntional gastrectomy should be performed in case of macrometastasis, deep and lateral margin positive, more than pT2 lesion in the permanent pathology.
3. H.pylori eradication - There was no clear evidence that H.pylori eradication reduced development of metachronous gastric cancer. H.pylori eradication was planned to perform according to physician's decision or patient's need. However, recently, the effect of H.pylori eradication in development of metachronous gastric cancer was published in NEJM (Choi et al. 2018). Therefore, from now on, H. pylori eradication will be recommended to enrolled patients with H.pylori.

Eligibility Criteria:
Inclusion Criteria:

* single lesion of adenocarcinoma in preoperative endoscopic biopsy
* clinical stage T1N0 in the preoperative evaluation of endoscopy and computed tomography
* tumor size: less than 3cm
* location: 2cm far from the pylorus or cardia
* aged 20 to 80
* ECOG 0 or 1
* patient who signed the agreement
* patient who is suspected to underwent laparoscopy assisted gastrectomy

Exclusion Criteria:

* indication of endoscopic submucosal resection
* inoperable due to poor cardiac, pulmonary function
* pregnant
* having allergic reaction, previous upper abdominal surgery except laparoscopic cholecystectomy, previous radiation therapy to upper abdomen
* diagnosed as malignancy within 5 years except carcinoma in situ of cervix cancer and thyroid cancer
DHL Survey on Generative AI for MyChart Messaging

The purpose of this study is to understand how patients feel about the use of computer programs to create responses when they send electronic messages to their doctors.

* The investigators will create short surveys online to ask patients how they feel about using computer programs that create messages in their medical records.
* The surveys will show fictional situations where patients ask questions and get answers from either real people or computer programs, with or without a disclosure about how the response was written.
* The investigators will ask the people taking the survey to share what they think about these situations using tools like rating scales, comparison scales, or written responses.
* If patients want to, they can provide their contact information to be part of future discussion groups. Participants do not have to give any personal information to complete the survey.

Eligibility Criteria:
Inclusion Criteria:

* Member of the Duke Health Listens patient advocacy community

Exclusion Criteria:

* Age \< 18