cyrilzakka/clinical-trials huggingface dataset:
Comparison of Post Isometric Relaxation and Post Facilitation Stretching on Hamstring Muscle Flexibility

The goal of this randomized clinical trial is to check the effectiveness of post isometric relaxation and post facilitation stretching on hamstring muscle flexibility in collegiate athletes.

The main question it aims to answer is:

* To compare the post isometric relaxation and post facilitation stretching techniques on hamstring muscle flexibility in collegiate athletes Participants were divided in two groups,
* Group-A was treated with baseline treatment of heating for 15min and rehab protocol post isometric relaxation in which 3-5 repetitions for 7-10 seconds hold in each session for three sessions per week in alternate days for four weeks.
* Group-B was treated with baseline treatment of heating for 15min and rehab protocol post facilitation in which 3-5 repetitions for 7-10 seconds hold in each session for three sessions per week in alternate days for four weeks.

Hamstring injuries are most common injuries in sports and there are many treatment methods and rehabilitation protocols available which are used according to the extent of injury. The main purpose of this study was to check the effectiveness of two treatment techniques on the hamstring muscle flexibility in collegiate athletes. Muscle Energy Techniques (MET) and their related post-isometric relaxation and post facilitation stretching techniques have demonstrated better results in improving flexibility of the tightened muscles. The study was a randomized clinical trial at Pakistan sports board and coaching center Lahore in which convenience sampling technique was used. This study included total 48 participants and for this purpose Open Epi tool software was used as a sample size calculation. Participants falling in this category were recruited into the study, those were male athletes with ages 18 to 35 having bilateral hamstring muscle tightness and acute hamstring injuries. Participants failing to fall in this category were excluded of the study such as females and athletes with hip, buttock and low back pain radiating to back of thigh and history of fractures within 6 months. Universal goniometer, SLR, active knee extension test and sit to reach test would be used as a tool for pre and post assessment of athletes. In this study the subjects were assigned through convenience sampling into two groups. Group A was treated with post isometric relaxation technique and group B was treated with post facilitation technique. Data will analyze through SPSS version 25.0

Eligibility Criteria:
Inclusion Criteria:

* • Age 18 to 35

  * Male
  * Athletes with hamstring muscle tightness (bilateral) or Acute hamstring injuries

Exclusion Criteria:

* • Athletes with hip, buttocks and low back pain radiating to back of thigh

  * History of fracture within 6 months
Eye Drop Dispensers: Safety, Efficacy and Comfort.

One aspect to eye drop adherence is successful instillation of the drops; however, it is well known that many patients struggle with this task. Difficulties may include aiming their drops,extending their neck, preventing excess drop leakage, avoiding contamination of the bottle tip and generating enough force to expel a drop from the bottle. Instillation aids are devices that aim to ameliorate one or more of these barriers.

Several eye drop dispensers had been developed in order to improved outcomes of eye drop instillation, including improved rates of successful administration and increased patient satisfaction compared to standard eye drop bottles.

In this study we aim to compare the eye drops various installation aids

subject will evaluate 2 dispensers by questioners. efficacy and safety of each one will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

* glaucoma patients

Exclusion Criteria:

* none
Effect of High Altitude Exposure, Acclimatization and Re-exposure on Right Ventricular Function in Lowlanders

Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude

Low altitude baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the ALMA base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 7 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing physiological testing. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 7 day altitude sojourn participants will return to the Santiago area (520 m) for a 7 day recovery period.

A second altitude sojourn cycle with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.

Measurements on study subjects will be performed at baseline (lowland, Santiago de Chile), then at 2nd day of altitude exposure and 7th day at altitude before returning to lowland; those are repeated in the second altitude sojourn cycle. Measurements will be conducted by qualified specialists using a portable ultrasound device.

Eligibility Criteria:
Inclusion Criteria:

* Born, raised and currently living \<800m
* No overnight stay at altitudes \>1500 m 4 weeks before the study

Exclusion Criteria:

* Previous altitude intolerance to altitude \<3000 m
* Pregnancy
* Health impairment, which requires regular treatment
Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients

A multi-center, prospective, randomized, double-blind, no-inferiority clinical trial designed to assess the the safety and efficacy of remazolam besylate in sedation of critically ill mechanically ventilated patients after surgery compared to dexmedetomidine.


Eligibility Criteria:
Inclusion Criteria:

* 18-64 years old
* must accept no-cardiac elective surgery
* must under general anaesthesia
* can be combined regional tissue anesthesia
* must admitted to ICU with tracheal intubation after general anaesthesia - expected mechanical ventilation time must more than 24 hours
* light or moderate sedation must needed

Exclusion Criteria:

* intracranial surgery or severe neurological or spinal cord disease
* schizophrenia, epilepsy, and Parkinson's disease
* coma, severe dementia, or language barrier before surgery
* cardiac dysfunction or arrhythmia
* severe liver dysfunction(Child-Pugh C class)
* severe kidney dysfunction
* use of dexmedetomidine or remifentanil besylate 24 hours before or during surgery
* pregnancy or lactation
* any investigational drug useage 30 days before surgery
* refuse to participant.
A Cohort Study on Thrombectomy for Stroke

The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke. Relatively sparse attention has been devoted to the role of baseline collateral circulation in patients with acute ischemic stroke who are candidates for revascularization. This study aim to investigate the correlation between baseline collateral circulation and the likelihood of opening of an arterial occlusion, the extent of reperfusion, tissue injury and clinical impairment.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years.
* Mechanical thrombectomy initiated within 24 hours after onset
* CT perfusion can be performed before the initiation of thrombectomy and 24h after thrombectomy

Exclusion Criteria:

* Contraindication to imaging with contrast agents
* Delay between imaging and beginning of thrombectomy \> 90 minutes
Patients With and Without Phonotrauma

There is a substantial need to identify objective measures associated with hyperadduction of the vocal folds to recognize those at higher risk of developing phonotrauma so that risk mitigation strategies can be implemented before phonotrauma develops. The overall objective of this proposed project is to investigate the sensitivity and direction of change in cepstral peak prominence (CPP) and the magnitude difference between the first two harmonics of the voice spectrum (H1-H2) in response to varied phonation patterns, which will be addressed using the following two aims:

Aim 1: Determine how CPP and H1-H2 change as a function of using pressed voice production in individuals without laryngeal pathology.

Aim 2: Examine the sensitivity (minimally detectable change) and responsiveness (minimal clinically important difference) of CPP and H1-H2 to detect changes in different voice production conditions.


Eligibility Criteria:
Control Group:

Inclusion Criteria:

1. 18-65 years of age (to avoid confounding physiological factors related to puberty or presbyphonia)
2. No history of or current voice disorder
3. Auditory perceptual presentation globally within functional limits (as determined by a voice specialized SLP).

Exclusion Criteria:

1. Atypical auditory-perceptual voice presentation
2. History of voice disorder or laryngeal surgery.

Patient Group:

Inclusion Criteria:

1. Diagnosed with phonotrauma (i.e., vocal fold nodules, vocal fold polyp, vocal fold pseudocyst, mid-fold edema) by a laryngologist.
2. 18-65 years of age

Exclusion Criteria:

1. Diagnosis of voice disorder not related to phonotrauma (e.g., vocal fold immobility, laryngeal dystonia, primary muscle tension dysphonia, etc.)
2. Previous history of laryngeal surgery or voice therapy (to avoid confounding effects of previous treatment).
Type Distribution of Human Papillomavirus in Adult African Women Diagnosed With Invasive Cervical Cancer

The aim of the study is to assess the distribution of the most frequent types of human papillomavirus in African women diagnosed with invasive cervical cancer.


Eligibility Criteria:
Inclusion Criteria:

* A female aged 21 years or more, presenting with a lesion macroscopically suggestive of invasive cervical cancer.
* Scheduled for cervical biopsy as per routine procedure at the participating institution on the day of the visit or on a later date.
* Written or oral-witnessed informed consent obtained from the subject prior to any study procedure.
* No prior chemo- or radiotherapy for cervical cancer.

Exclusion Criteria:

Not applicable
Pennsylvania Abusive Head Trauma Prevention Program

This project is designed to evaluate a statewide, hospital-based parent education program to prevent abusive head trauma (AHT) in Pennsylvania, and investigate the additional effectiveness and cost-effectiveness of "booster" sessions of parent education delivered to parents at primary care provider offices in central Pennsylvania.

Specific Aims:

1. Assess the effectiveness of an established statewide program of hospital-based postnatal parent education about violent infant shaking, provided at a single consistent point in time between the infant's birth and hospital discharge, in reducing the incidence of AHT.
2. Identify which component(s) are the most important mediators of the intervention's effectiveness; determine whether the intervention effect is more directly related to changes in perpetrator or caregiver behavior; and determine the effectiveness of the intervention among various socioeconomic groups.
3. Determine the cost effectiveness of the hospital-based program.
4. Establish the feasibility, additional costs, and effectiveness of a combined program of repeated exposure delivered both post-natally in the hospital and during follow up 2-, 4- and 6-month outpatient health maintenance visits with the pediatric care provider.

Upon the birth of the child, all parents (mothers, and whenever possible, fathers or father figures) will be asked to read written materials and view an 8-minute video on the dangers of violent infant shaking. Parents will be asked to voluntarily sign a commitment statement affirming their receipt and understanding of the materials; these commitment statements will be sent to the Principal Investigator. A random subset of parent participants will be asked to voluntarily answer a short questionnaire about their impressions of the materials. In addition, 31 counties in central Pennsylvania will be randomly divided into two groups. In 15 counties, the hospital-based intervention will remain as described above. In the other 16 counties, all primary care providers having offices in those counties will be asked to provide all parents of newborns at the 2-, 4-, and 6-month immunization visits another set of written materials about violent infant shaking and voluntarily sign a response form that they read and understood the materials. Participating parents in this group will also be asked if they would be willing to complete a short telephone survey when the infant is 7 months old (and if so, asked to provide a telephone number). The telephone survey asks questions about the intervention materials and parents' perception of the information, and seeks to determine the mediators of a program effect. An invitation letter will be sent to a control group of parents who do not receive the office-based intervention to ask if they would be willing to complete the short telephone survey when their infant is 7 months old.

Eligibility Criteria:
Inclusion Criteria:

* Parents giving birth in a PA hospital
Treatment Trial for Acute Central Serous Chorioretinopathy

Central serous chorioretinopathy (CSC) is a relatively frequent eye disease in younger patients. It is characterized by serous detachment of the neurosensory retina with or without serous detachment of the retinal pigment epithelium (RPE), which can cause vision drop, image distortion, loss of color and contrast vision. Although nonfoveal focal leakage can be treated with traditional laser photocoagulation, but it has the side effects of causing RPE atrophy, scotoma, or secondary CNV. Photodynamic therapy (PDT) is another effective treatment but it's more than most families can afford to pay because of the high cost, what's more, it is accompanied with side-effects, such as choroidal ischemia, retinal pigmental epithelium (RPE) atrophy and RPE rip.

To date there is no international consensus on the optimal treatment of CSC Many retrospective studies suggest that micropulse laser (MPL) therapy may also be effective without obvious complications in this disease.

The purpose of this study is to evaluate the effect of micropulse laser (MPL) on acute central serous chorioretinopathy compared with the traditional laser coagulation.

The study is a prospective randomized controlled trial about 577nm micropulse laser versus traditional laser coagulation therapy on acute central serous chorioretinopathy. The primary outcome measures is the proportion of eyes with complete absorption of subretinal fluid 3 months after treatment.

Eligibility Criteria:
Inclusion Criteria:

1. onset for the first time, as an episode duration of less than 6 months
2. patient was between 18 and 55 years of age
3. the presence of subretinal fluid(SRF) involving the macula and detected by use of optical coherence tomography (OCT)
4. active fluorescein leakage during fluorescein angiography (FA)
5. best corrected visual acuity (BCVA) more than 0.1, and less than 1.0

Exclusion Criteria:

1. previous PDT, focal photocoagulation, intravitreal injections of anti-vascular endothelial growth factor, or ocular surgery
2. other macular abnormalities such as choroidal neovascularization(CNV) or polypoidal choroidal vasculopathy(PCV)
3. retinal atrophy
4. pregnancy
5. inability to obtain photographs or to perform FA
6. use of steroid systemically or topically in the last 6 months
Effect of Transcranial Magnetic Stimulation on Visual Functions of Adult Amblyopia: a Preliminary Study

Amblyopia, with a prevalence rates of 3% in adult population, is a common cause of vision impairment. It is characterized by impaired vision in one or both eyes because of disruption of normal visual stimuli and underdevelopment of the visual cortex, leads to lifelong visual deficits affecting both monocular and binocular visual function. Common causes of amblyopia include refraction error, anisometropia, strabismus and visual deprivation arising from ptosis or congenital cataract. Our previous studies had shed light on the relationship between abnormal early visual experience, and development of later amblyopia and possible neural developmental disorders. Functional recovery is difficult when neuroplasticity slows down at the end of the critical period. To date, there is no established effective treatment for adult amblyopia.

Repetitive transcranial magnetic stimulation (rTMS) is one of the non-invasive stimulations had been used widely as a research tool to understand the brain functions and an established treatment modality in neuropsychiatric diseases. Theta burst stimulation (TBS) is a newer form of rTMS protocol which have a major advantage over traditional rTMS in their reduced administration duration and allowing stimulation at significantly lower intensities to attain comparable effects. TBS had been demonstrated to able to improve functions in participants with visual disorders. However, studies of its use on adult amblyopia are scarce. Due to lack of efficient treatment at present, it is of scientific significance to conduct placebo-controlled experiments on this topic. Investigators will evaluate the effect of three regimens of TBS (intermittent, continuous and sham), after one session and accumulative sessions, on visual functions of amblyopia adults shortly after treatment and 2 weeks later (lasting effect), in order to evaluate its potential role in amblyopia and find out the best paradigm for amblyopia treatment.


Eligibility Criteria:
Inclusion Criteria:

1. Adult amblyopia participants, aged 20-50 years old.
2. Based on inclusion criteria, there was a minimum of 2 lines difference in BCVA between the 2 eyes.
3. An amblyogenic factor and history of amblyopia treatment was recorded

Exclusion Criteria:

1. Unstable vital sign
2. History of brain injury and/or head trauma
3. Neurological and psychiatric disease
4. Seizures or family history of seizure
5. Pregnancy
6. Uncontrolled migraine or the presence of metallic implants or shunt in the head or torso
7. Wide region of ischemic cicatrix, multiple sclerosis, taking tricycle antidepressants,
8. Analgesics or any drugs may decrease the threshold for inducing seizure
9. Experienced sleep disorders during the rTMS treatment
10. Severe alcoholism or taking seizure drugs
11. Severe heart diseases or uncontrollable migraine caused by high intracranial pressure
A Safety and Tolerability Study of CTP-730 in Healthy Volunteers

This is a Phase 1, single center, single-ascending dose, randomized study

Following a Screening period of up to 21 days, eight (8) subjects in each cohort, 6 subjects randomized to CTP-730 and 2 subjects randomized to placebo, will be admitted to the clinical research unit (CRU) on the evening before dosing and remain sequestered at the study site until after the last inpatient blood sample is collected at 48 hours.

Eligibility Criteria:
Inclusion Criteria:

* Healthy male and female volunteer subjects, 18 to 50 years of age, inclusive.

Exclusion Criteria:

* Current significant medical condition, laboratory abnormality, or psychiatric illness
* History of clinically significant central nervous system (eg, seizures), cardiac, pulmonary, metabolic, renal, hepatic, or gastrointestinal (GI) conditions
* PR interval ≥ 220 msec or QRS duration ≥ 120 msec or QTcB / QTcF interval \> 450 msec
* Elevated liver function tests greater than twice the upper limit of normal
* Positive blood screen for human immunodeficiency virus (HIV antibody), hepatitis B virus surface antigen, or hepatitis C virus antibody
* Urinalysis positive for protein or glucose
* A positive screen for alcohol, drugs of abuse, or tobacco use.
* Inability to comply with food and beverage restrictions during study participation
* Donation or blood collection or acute loss of blood prior to screening
Exercise and Emotional Learning in Posttraumatic Stress Disorder

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

The proposed project would build on our published pilot data and animal models to demonstrate that moderate intensity physical exercise delivered after exposure therapy engages fear circuitry and enhances the consolidation of therapeutic safety learning, thereby enabling enhanced symptom reduction for PTSD. Adults with PTSD related to interpersonal violence (IPV) exposure would complete an initial session of imaginal exposure to traumatic memory cues adapted for an MRI setting. This would be followed by 30-mins of moderate intensity exercise or low intensity exercise control. Participants would return 24-hrs later to complete a second session of imaginal exposure with MRI.

Eligibility Criteria:
Inclusion Criteria:

* Adults with PTSD related to interpersonal violence

Exclusion Criteria:

* Active or recent (within the last 3 months) severe substance use disorder(s)
* Active or recent (within the last 3 months) suicidal, psychotic, or manic symptoms/ episodes
* Significant developmental disabilities
* Current daily benzodiazepine or stimulant use with inability to abstain for study sessions
* Recent changes in psychiatric medication or trauma focused cognitive-behavioral therapy (CBT) (past 4-weeks)
* Medical condition(s) that prohibit exercise
* History of traumatic brain injury (TBI) with loss of consciousness \> 30 mins
* Magnetic resonance imaging (MRI) contraindication(s)
* Positive pregnancy test
* History of seizure disorder
* Spontaneous seizure(s) within the last 3 months