cyrilzakka/clinical-trials huggingface dataset:
Dentine Hypersensitivity Treated With Laser and Fluoride.

The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient after cold air blow stimulus.

After treatment application, the follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months

The aim of the present report is to evaluate the amino fluoride gel with or without application of diode laser on pain due to dentine hypersensitivity.

The study is designed with a split mouth design. NRS (numerical rating scale) index will be used to evaluate the pain suffered by each patient. The pain response will be stimulated by thermal urge (cold air blow). Teeth will be divided in two groups. The treatment group, treated with 980nm diode laser and amino fluoride gel; the control group, treated only with amino fluoride gel.

The follow-up timing planned for each patient will be at 1 week, 1 month, 3 months and 6 months. In these follow-up sessions a revaluation of the pain response is performed using the NRS index.

Eligibility Criteria:
Inclusion Criteria:

* Teeth in good periodontal health
* Good oral hygiene
* Dentine hypersensitivity: NRS (Numerical Rating Scale) ≥ 3

Exclusion Criteria:

* Teeth local disease or fractures in treatment area
* Irreversible teeth necrosis or pulpitis
* Definitive restorations or veneers
* Recent use of painkillers or anti-inflammatory drugs,
* Treatment for dentine Hypersensitivity less than 6 months before the study start
* Therapies contraindication
Cognitive Impairment and Imaging Correlates in End Stage Renal Disease

This is an observational cohort to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.

Eligibility Criteria:
Inclusion Criteria:

* Pre-transplant ESRD patients who are listed for renal transplantation
* Able to sign pre-transplant consent on their own will
* Have english as their native language

Exclusion Criteria:

* Current use of antipsychotics or anti-epileptics
* Inability to read or write which will limit their ability to perform the cognitive tests
* Claustrophobia or inability to get MRI for other reasons
* Unable to sign consent
Evaluation of High Dose Methotrexate Toxicity

This study aims to:

1. Evaluation of high dose methotrexate related toxicities among children admitted to Sohag Oncology Centre.
2. Role of methotrexate blood level in prediction of high dose methotrexate related toxicities.
3. Role of Cystatin C as a predictor for acute kidney injury in high dose methotrexate related toxicities.
4. Factors affecting outcome of high dose methotrexate related toxicities.

It is a prospective observational study will be carried out on children receiving high dose methotrexate in Sohag Oncology Centre with one-year observation starting from January 2024.

All children receiving high dose methotrexate in Sohag Oncology Centre and fulfill the study inclusion criteria with one-year observation starting from January 2024. Informed consent will be taken from the parents/guardians.

A Prepared sheet to collect data related to this study that include:

1. Socio-demographic data: e.g. age, sex, residence in addition to dose of MTX and tumor type.
2. General and systemic manifestations: gastrointestinal manifestations, neurological manifestations, respiratory and hematological manifestations.
3. Investigations: blood samples will be collected for CBC, Urea, Creatinine, ALT, AST, Methotrexate level and Cystatin C.
4. Treatment lines: fluid, folinic acid, alkalinization of urine, blood elements, hemodialysis and colony stimulating factors.
5. Outcome: complete recovery, residual effects, complications or death.

Eligibility Criteria:
Inclusion Criteria:

* Children admitted to Sohag Oncology Centre, age from 1 to 18 years
* receive high dose methotrexate therapy equal to or more than 1 gm/m2 surface area.

Exclusion Criteria:

* WBCs less than 1000 / microliter
* Platelet count less than 50000 / microliter
* Renal affection
* Hepatic affection
* Respiratory affection
* Diabetes mellitus
* Cardiovascular disease
NAITRE (PreNAtal Care in deprIvaTed enviRonnEment)

This study aims to evaluate the impact of financial support on improving the management of prenatal care in pregnant women with low incomes. The judgment criterion is clinically pertinent: complications of pregnancy. This study also aims to evaluate attitudes to this approach through a qualitative survey.

It is planned to include 4000 women distributed into two arms of 2000 each. One group will receive financial support (prepaid payment card credited for each consultation attended according to the scheduled follow-up as recommended by the Haute Autorité de Santé); the other group will not. The management of the pregnancy for both groups will not be modified.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant women
* Age \> 18 years
* 1st consultation before the 26th week of amenorrhea
* Recipient of free health care (Couverture Maladie Universelle, Couverture Maladie Universelle-Complémentaire)
* Who have provided written informed consent to take part in the study

Exclusion Criteria:

* Persons without national health insurance cover
* Persons unable to understand the information on the study, despite the help of a translator or a person of trust if necessary
* Persons under guardianship
Physical Co-morbidity, Poor Health Behaviour and Health Promotion in Verona Patients With Functional Psychoses

The study evaluates the efficacy of health promotion strategies on diet and physical activity in patients with psychosis. Half of the participants will receive an intervention protocol based on education and behavioural change, while half will not receive it.

Epidemiological studies investigating the mortality and physical health of mental patients have provided substantial evidence of an excess mortality and of a substantially higher prevalence of physical co-morbidity as compared to the general population. These findings have been related to a higher prevalence of risk factors like high blood pressure, high plasma cholesterol and obesity, unhealthy lifestyles, medication side-effects.

The number of clinical trials and intervention studies in this area is still scanty and their scientific strength is relatively modest. The present research project aims at implementing preventive strategies related to dietary habits and physical exercise, and studying their efficacy with a randomized controlled study.

Eligibility Criteria:
Inclusion Criteria:

* ICD-10 diagnosis of affective or non-affective functional psychosis (codes F20-22, F24, F25, F28-F31, F23.3, F33.3)
* one or more contacts with the CMHS in the 3 months preceding the beginning of the recruitment
* Age 18-65

Exclusion Criteria:

* moderate or severe mental handicap (learning disability)
* organic brain disorders
* lack of capacity to consent to inclusion
* subjects already involved in individual treatment related to diet and physical exercise
* subjects deemed unable or unfit to participate in the proposed physical activities
Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients

The aim of this study is to facilitate weaning by switching between invasive and noninvasive ventilation in difficult-weaning patients.

This study only enrolled patients with tracheotomy. When a patient is eligible to this study, he or she is randomly assigned to intervention or control group.A patient in intervention group is switched to noninvasive ventilation by masking the tracheotomy tube. If the patient presents distress in noninvasive ventilation, he or she is switched to invasive ventilation. If the distress relieves, patient is switched to noninvasive ventilation again until the patient successfully weans from ventilator. In control group, the patient is weaned as the conventional methods.

Eligibility Criteria:
Inclusion Criteria:

* duration of invasive ventilation ≥14 days
* anticipation of difficult weaning
* Glasgow Coma Scale ≥13
* no upper airway obstruction
* presence of spontaneous breath

Exclusion Criteria:

* age less than 18 or more than 85 years
* contraindications for noninvasive ventilation
* anticipation of survival less than 6 months
* refusal of tracheotomy
Wide Use of Paperless Partograph in Evaluation of Labour

Paperless partograph wide using in labour room as simple tool in evaluation of labour

Both world health organization ( WHO) PARTOGRAPH and modified world heath organization (WHO)PARTOGRAPH are too long labour tools in evaluation of labour so we need simple tool in evaluation of labour

Eligibility Criteria:
Inclusion Criteria:

* Spontaneous labour
* cephalic presentation
* pregnant 37 weeks up to full term

Exclusion Criteria:

* mail_presentation
* induced labour
Combining Non-Invasive Brain Stimulation With Cognitive Behavioral Intervention in Substance Use Disorder

The current study aims to examine the safety and feasibility of utilizing tDCS to enhance affect-laden episodic memory consolidation among adults with co-occurring alcohol use and anxiety disorders who have recently undergone detoxification as a step toward the translational clinical application of this approach.


Eligibility Criteria:
Inclusion Criteria:

* DSM IV diagnosis of panic disorder (with or without agoraphobia), generalized anxiety disorder, or social anxiety disorder within the past 30 days
* DSM IV diagnosis of alcohol dependence within the last 30 days
* inpatient treatment at Lodging Plus primarily for alcohol (vs. other drug) dependence
* alcohol use in the 30 days preceding the study
* willingness to provide informed consent
* minimum of a sixth grade English reading level (deemed necessary to complete study materials); as determined by their being able to read and understand the consent form.
* Living within reasonable driving distance (1 hour or less) of the Twin Cities to allow for in-person follow-up interviews

Exclusion Criteria:

* lifetime history of psychosis or mania by history.
* cognitive (e.g., dementia) or physical impairment (e.g., blindness) that interferes with study participation report or as judged by PI/study physician.
* Current suicide risk as deemed by the PI and study physician to be serious and ongoing
* any medical condition or treatment with neurological sequelae (e.g., stroke, tumor, loss of consciousness of more than 30 minutes, HIV, seizures)
* history of ECT
* document loss of consciousness (LOC) for longer than 30 minutes or LOC with neurological sequelae
* pregnancy
* Although seizures are not a known risk of tDCS intervention (Fregni et al., 2006; Nitsche et al., 2008), anyone with a history or a risk for seizures will be excluded from the study
* anyone with metal objects implanted in their head or neck
* anyone taking stimulant medications for any reason as we wish to avoid two sorces of neurostimulation
Randomized, Controlled Trial of Posterior C1-2 Fusion Versus Bracing Alone for Treatment of Type II Odontoid Process Fractures in the Elderly

This prospective study addresses one of the most controversial topics in the treatment of cervical spine trauma: the management of type II odontoid process fractures in the elderly. It is the hypothesis that surgical treatment will result in improved functional outcome measures, neck pain and mortality rates as compared with nonsurgical management. Furthermore, it is hypothesized that surgical treatment of odontoid process fractures will limit hospital re-admissions and development of medical complications secondary to prolonged immobilization in a cervical orthosis and delayed surgery related to late fracture displacement, which are often associated with non-operative care. Additionally, data from this study will be useful in identifying patient-specific predictors of improved outcome which can be used to optimize treatment algorithms and more effectively counsel patients who sustain these injuries.


Eligibility Criteria:
Inclusion Criteria:

Patients to be considered for trial enrollment will include those:

1. ages 65 and older;
2. presenting with type II odontoid fracture confirmed by CT scan to one of the study centers;
3. deemed appropriate by the attending surgeon involved for C1-2 posterior cervical fusion procedure if surgical management were to be indicated
4. able to independently cooperate in the completion of all study consents, forms and documents.
5. able to speak, read and write English at an elementary school level

Exclusion Criteria:

Patients to be excluded from trial enrolment include:

1. those with previously documented type II odontoid fracture;
2. those with odontoid fracture related to malignancy or infection;
3. those with associated spinal cord injury
4. those with other cervical, thoracic or lumbar injuries requiring surgical intervention
5. those with aberrant/anomalous local anatomy which precludes posterior placement of C1/2 instrumentation
Eccentric Training Versus Active Release Technique On Quadriceps In Patients With Dynamic Hip Screw

This study will compare the effects of Eccentric training and Strength training with priory applied Active Release Technique on Quadriceps muscle in post operative patients of Dynamic Hip screw. Participants would be equally divided into two groups each receiving specific type of protocol besides standard post operative protocol of Dynamic Hip screw

The study is Randomized Control Trial, being conducted at Fauji Foundation Hospital Rawalpindi .This study will compare the effects of two techniques addressing the contractile as well as non-contractile element of Quadriceps in early phase of Rehabilitation.

Sample size of 18 was calculated using software Epitool with 95% confidence interval and 80% power. Individuals of selected population will be randomly allocated as 9 in Eccentric group and 9 in Active Release Technique group by sealed enveloped method.

Eligibility Criteria:
Inclusion Criteria:

* Age: 40-65 years
* Patient with stable vitals on 3rd post-operative day
* Postero-Lateral Hip surgical approach

Exclusion Criteria:

* History of prior fracture
* History of fall
* Multiple fractures
* Cognitive impairment (Score ˂26 on Montreal cognitive assessment)
* Co-morbid disease
Efficacy, Safety and Tolerability of Different Bowel Preparation Before Colonoscopy in Children Over 2 Years Old

Electronic colonoscopy plays an important role in the diagnosis and follow-up of intestinal diseases in children.

The adequacy of bowel preparation before colonoscopy is particularly important for the visualization of intestinal mucosa under colonoscopy. Some studies have shown that bowel preparation must be customized according to the age, weight and clinical status of the child. However, there is no internationally recognized standard scheme for pediatric intestinal reserve. In pediatric clinical trials, polyethylene glycol with electrolyte solution (PEG-ELS) is more effective than bisacodyl, folium sennae and magnesium citrate. PEG-ELS is an electrolyte balanced isotonic solution, which can be used to clean the intestinal tract by large volume irrigation. Polyethylene glycol 4000 is a long-chain linear polymer, which can hardly absorb and decompose after oral administration. It can effectively increase the composition of intestinal fluid, stimulate intestinal peristalsis, cause watery diarrhea, and achieve the purpose of cleaning the intestine. The inorganic salt composition and proper amount of water in the formula ensure the balance of water and electrolyte exchange between intestinal tract and body fluid. In this study, PEG-ELS short protocol and long protocol were selected for intestinal preparation, and the effectiveness and safety of different intestinal preparation protocols under electronic colonoscopy for children over 2 years old were compared.

Eligibility Criteria:
Inclusion Criteria:

* Newly diagnosed children in Department of Gastroenterology at Children's Hospital of Fudan University
* According to the indications of electronic colonoscopy, colonoscopy was performed for the first time
* Age: 2-22 years old

Exclusion Criteria:

* Having contraindications of electronic colonoscopy
* Having contraindications of general anesthesia
* Previous abdominal surgery
* Chronic constipation
* There is evidence of intestinal stenosis and gastrointestinal malformation
* Laxatives or drugs in the intestinal preparation protocol of this study have been used before bowel preparation
* Disagree the use of the bowel preparation protocol developed in the study
A WeChat-based Intervention to Support Breastfeeding

The aim of the randomized controlled trial (RCT) is to evaluate the effects of an intervention program delivered via WeChat platform to support exclusive breastfeeding in China. WeChat, a free smart phone application, is the most popular social networking platform in China. It will be used to deliver health educational messages to the study participants. Our hypothesis is that the intervention program can lead to at least a 10% increase in exclusive breastfeeding prevalence at 6 months when compared to the control group.

A multicenter RCT of 1,000 participants will be conducted at four maternity hospitals in Chengdu, China. Eligible pregnant women who consent to participate will be recruited from the antenatal clinic at around 30 weeks of gestation and will be randomly assigned to either the intervention or control group on a 1:1 ratio.

After randomization, all participants will be asked to scan a Quick Response code to follow our WeChat public account, which can send push notifications to alert participants for new content, topics, links to a searchable library and frequently asked questions and answers. From baseline until childbirth, control group participants will receive non-breastfeeding related messages, such as healthy lifestyle and nutrition during pregnancy, from WeChat, whereas the intervention group participants will receive breastfeeding related messages, including preparation for breastfeeding after birth and the health benefits of breastfeeding, from WeChat. After childbirth, intervention group mothers will continue to receive information about breastfeeding for 6 months. The investigators will use WeChat to remind mothers about the importance of exclusive breastfeeding, build confidence and motivate them to continue exclusive breastfeeding. Meanwhile, the control group participants will receive information on other topics of interest to mothers, such as immunization, safety, infant growth, and etc.

Each participant will be interviewed in person by trained nurses at baseline, at discharge and be interviewed by telephone using structured questionnaires at 1, 4, and 6 months postpartum to collect detailed information on breastfeeding practices. All participants receive normal prenatal and postpartum maternity services. Cox proportional hazard models and multilevel mixed regression models will be performed respectively to compare the duration of exclusive breastfeeding and the rates of exclusive breastfeeding within six months postpartum between intervention and control groups.


Eligibility Criteria:
Inclusion Criteria:

* own a smart phone;
* 18 years or above;
* sufficient language skills (completed secondary school education);
* carry a singleton fetus;
* at a gestational age of 28 to 30 weeks;

Exclusion Criteria:

* have existing medical conditions or pregnancy complications which may inhibit breastfeeding initiation, according to their medical doctor;
* intend to give birth in health institutes other than the study hospitals.
A Study to Investigate the Process by Which ABT-614 is Absorbed, Distributed, Metabolized and Eliminated in Humans

The objective of this study is to determine the amount of ABT-614 in the cerebral spinal fluid and blood after administration of a single dose and after administration of daily doses for 14 days in healthy volunteers.


Eligibility Criteria:
Inclusion Criteria:

* Healthy male subjects between 18 and 40 years of age

Exclusion Criteria:

* History of bleeding disorders or deep vein thrombosis (DVT)
* Previous gastrointestinal (GI) surgery or chronic GI disease
* History of spinal surgery
* History of significant, chronic low back pain
* History of frequent headaches
My Choices: Efficacy and Implementation Study

The aim of the study is to assess the efficacy of the My Choices - Alcohol program by comparing alcohol-use of people before and after doing the program to people that did not do the program on the same period of time (3 months).

People with an alcohol addiction problem consume an average of 26.3 (sd = 12.4) drinks per week (Cournoyer et al., 2010). To observe a decrease of 25% in this average number of drinks for the group participating in the program " My Choices " immediately compared to the delayed group at 3 months, we need a sample size of 100 participants. This calculation assumes an alpha of 5%, a power of 80% and unbalanced groups due to the randomization method used. Considering an attrition rate of 11.3% at 3 months and 20% at 6 months (Tremblay et al., Submitted), it will be necessary to recruit at least 120 participants to maintain the required number for analyses.

References Cournoyer, L.-G., Simoneau, H., Landry, M., Tremblay, J., \& Patenaude, C. (2010). Évaluation d'implantation du programme Alcochoix+ (FQRSC #2008-TO-120890). F. q. d. r. s. l. s. e. l. culture.

Tremblay, J., Dufour, M., Bertrand, K., Saint-Jacques, M., Ferland, F., Blanchette-Martin, N., Savard, A.-C., Côté, M., Berbiche, D., \& Beaulieu, M. (Submitted). Efficacy of a Randomized Controlled Trial of Integrative Couple Treatment for Pathological Gambling (ICT-PG): 10-Month Follow-Up. Journal of Consulting and Clinical Psychology.

Eligibility Criteria:
Inclusion Criteria:

* Adults with at risk alcohol use (alcohol use over the Canadian low-risk alcohol drinking guidelines, without or with low consequences associated with their alcohol use).

Exclusion Criteria:

* Score at the DEBA (Assessment and Screening of Assistance needs) indicates a need for specialized treatment.
* Hospitalization for mental health problems in the last 30 days
* People with unstable mental health condition