cyrilzakka/clinical-trials huggingface dataset:
Risk of Chronic Kidney Disease in Bronchial Asthma

the study aims to determine the frequency and factors associated with chronic kidney disease among asthmatic patients in order to determine persons who are at risk of developing chronic kidney disease and require strict follow up in long run , to evaluate severity of asthma as a potential risk for developing kidney injury , to evaluate relationship between different inflammatory markers with severity of asthma and risk of deneloping chronic kidney disease


Eligibility Criteria:
Inclusion Criteria:

* all children diagnosed as bronchial asthma at sohag university hospitals from age of 2 years to age of 18 years and donot have any associated disease

Exclusion Criteria:

* persons who have any chronic illness persons who have any associated disease with bronchial asthma persons who missing clinical and laboratory investigations persons who refusing to give written informed consent for the study
Dysmenorrhea of Emotional Freedom Techniques (EFT) and Its Effect on Perceived Stress Level

The aim of the study is to determine the effect of EFT application on the level of dysmenorrhea and stress perception in women with dysmenorrhea. For this purpose, EFT will be applied to women with dysmenorrhea with high stress perception assigned to the experimental and control groups, and their stress perceptions and dysmenorrhea levels will be re-evaluated after the application. Perceived Stress Scale (PSS) and Visual Analog Scale (VAS) will be used in the research.

Application of the experimental group The women in the experimental group will be informed about the function, click points and application of EFT through a written material. The EFT application will be explained practically by a certified researcher and the application steps will be followed. Women who underwent EFT will be contacted again within a week or two and asked how they feel and feedback will be received about whether the problem or problems during the first meeting still bother them. By asking women to show how they feel on the SUE scale, the EFT application will be repeated until the woman expresses positive emotions on the SUE scale. The number of EFT applications will be decided according to the woman's condition. After the EFT application is completed, the woman will be re-evaluated with VAS and PSS in the 1st and 2nd months. It will be recorded and reported as perceived stress when assessing The EFT practitioner researcher's certification is S.E.M. It is a certificate with a total scope of 50 hours, including face-to-face training, issued by the Academy considering International Education standards and criteria. The training was given by a trainer with a trainer certificate on EFT. The researcher, who has a nationally and internationally valid certificate, has prepared a guideline in parallel with the training he has received, received expert opinions on the guideline and will carry out its pilot application.

Application of the control group A meeting will be held with the women in the control group at the beginning of the research and information will be given about the study. The researcher will open a WhatsApp group for the women in the control group and follow them to eliminate their lack of information. Throughout the research, women in the control group will continue their routine coping habits regarding dysmenorrhea and perceived stress levels, and this group, like the experimental group, will be re-evaluated with VAS and PSS in the 1st and 2nd months of the research.

Eligibility Criteria:
Inclusion Criteria:

* Must be between 18-49 years old and single,
* Must be literate and willing to participate in the study,
* There should be no wounds, scars or infections in the area where EFT will be applied.
* The perceived stress level must be high and they must be experiencing dysmenorrhea

Exclusion Criteria:

* There should be no change in menstrual cycle in the last six months,
* There must be no communication problems or illnesses that may prevent work.
Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.

The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and "Kirtan Kriya" meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).

Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and "Kirtan Kriya" meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Mild cognitive impairment amnestic type
* Clinical Dementia Rating scale score of 0.5
* SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
* Capacity to provide informed consent.

Exclusion criteria:

* Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
* Any disabilities preventing their participation in the memory enhancement training (MET) (e.g. severe visual or hearing impairment)
* Insufficient English proficiency
* Diagnosis of dementia
* Mini Mental Health Examination score of 24 and below
* Psychoactive medications
* Participation in a psychotherapy that involves cognitive training
* Do not meet criteria for Mild cognitive impairment subtype
* Prior or current training in yoga.
Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation

Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of allogeneic bone marrow transplantation (BMT). Although augmentation of immunosuppressive treatment might help but the only effective treatment for BOS is by lung transplantation.

Macrolide antibiotics, which have been licensed to use as antibacterial agents for decades, have been found to have immunomodulatory properties in addition to their antibacterial activity. Low dose Azithromycin, an antibiotic of the macrolide family, has been shown to have promising result in a pilot study in treating BOS associated with lung transplantation. We propose to perform a prospective, randomised, double blind study to test the efficacy of Azithromycin in treating BOS after BMT. Patients with proven BOS after BMT will be randomised into two groups based on lung function parameters. One group will receive low dose Azithromycin while placebo will be provided for the other group. Lung function will be serially monitored at 3 month, 6 months and 12 months after commencement of treatment with drug/placebo. If Azithromycin was proven effective in treating BOS then all patient with proven BOS should be treated with this drug.


Eligibility Criteria:
Inclusion Criteria:

* Confirmed BOS post BMT
* Informed consent

Exclusion Criteria:

* Women currently pregnant or nursing
* Allergy to macrolide
Ultrasonographic Measurements of Uterine Junctional Zone and Association With In Vitro Fertilization Treatment Outcome

The aim of this study is to prospectively examine the relationship of the uterine junctional zone thickness, evaluated by ultrasonography and In Vitro Fertilization (IVF) treatment outcome. The study hypothesis is that the uterine junctional zones of women who did not achieve pregnancy will be thicker than those of the women who do achieve pregnancy

Ultrasounds of women who achieve pregnancy after IVF treatment will be compared to ultrasounds of women who do not achieve pregnancy. Their uterine junctional zone thickness will be compared.

The study hypothesis is that the uterine junctional zones of women who did not achieve pregnancy will be thicker than those of the women who do achieve pregnancy.

Eligibility Criteria:
Inclusion Criteria:

* Undergoing IVF treatment due to male factor, polycystic ovary syndrome and unexplained infertility

Exclusion Criteria:

* Low ovarian reserve
* Having undergone more than one D\&C
Follow up of Patients Treated With Cognitive Behavioural Therapy for Hypochondria From 1997 to 2007

Research has shown that cognitive behavioural therapy is effective in treating hypochondria. However, no studies have examined the long term effect. The investigators have followed 56 patients treated for hypochondria between 1997 and 2001 and the investigators are now doing a 10 year follow-up (Part I). In another part of the study (Part II) the investigators compare the effect of 16 sessions vs. 5 sessions, with a follow-up period of at least 2 years. The investigators hypothesis is that the initial 1 year improvement will be sustained and that 5 sessions will yield the same results as 16 sessions.

The follow-up includes a telephone interview by independent researcher and the patients fill in the following questionnaires:

Whiteley Index (measures health anxiety), VAS-scales for health anxiety, worrying about symptoms and body checking, SF-36 (health related quality of life), Giessen Subjective Complaints List, Spielberger Trait and State Anxiety Scale Beck Depression Inventory, Eysenck Personality Questionnaire, General Health Questionnaire (GHQ 28), Somatic Amplification Scale,

Eligibility Criteria:
Inclusion Criteria:

* Fulfilling ICD-10 criteria for hypochondriacal disorder

Exclusion Criteria:

* Unwillingness to participate
* Substance abuse
* Serious psychological (f.inst. psychosis, major depression) or somatic (f.inst. cancer) disease
Ambulatory Screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD).

To evaluate, in primary care, the sensitivity of Heterophory-Vertical-Labile (HV-Labile) in ambulatory screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD). in children aged 8 to 12 years.

General practitioners during a day of professional training on learning disabilities will be trained to perform the proprioceptive Maddox, to search for a HVLabile.

Each trained practitioner will then test at least six children aged 8 to 12 years old in his or her practice, seen at random

250 to 300 physicians will be trained as part of this research

EXPERIMENTAL DESIGN

* Cross-sectional study with prospective recruitment.
* Search for a Vertical Labile Heterophory (HV-Labile).
* Prescription of a standardized speech and language screening assessment for HV-Labile, and in the same number of children without HV-Labile by secondary coupling.
* Delivery of symptomatic questionnaire.
* In case of learning disabilities, the attending physician should look for a possible etiology.
* Adapted speech therapy care for more than six months.
* Speech and language therapy check-up at more than six months.

Eligibility Criteria:
Inclusion Criteria:

The population studied is composed of children:

* from 8 to 12 years old
* seen for any reason for consultation in general practice
* Schooled in an ordinary environment since the Preparatory Course in France
* Francophone parents
* One of whose parents has signed the consent
* Consent of the child
* Social Insured

Exclusion Criteria:

The background and living conditions that may promote secondary learning disabilities, for example:

* Child with a known intellectual disability (Wisc)
* Child in IME (Institut Médico Educatif)
* Child followed in SESSAD (Specialised education service at home)
* Child not knowing how to answer the questions asked
* Child with a known etiology causing learning disabilities (epilepsy, autism spectrum disorder, hearing impairment, visual impairment (deafness, blindness, low vision))
* Child on treatment (antiepileptic, neuroleptic, antidepressant, anxiolytic)
* Child under the care of a psychiatrist,
* Child followed by the CMP (Centre médico-psychologique)
* Child living in an institution,
* Adopted child
* A child whose mother has experienced known depression during the child's early childhood (0-18 months) because it causes attachment disorders, which can impact the child's development, including learning
* Child of a family that has lived through more than two family recompositions
* Child known to be a victim of abuse.
* Out of school child.

To determine the presence of an HV-Labile

* Child with a known visual correction greater than + or- 2 diopters
* Known amblyopic child
* Known strabic child
* Child with no known binocular vision.
Prevalence of Obesity Among Adult Patients With Congenital Heart Disease: a Population-based Study

The study was conductede to examined the prevalence of obesity in a large Danish ACHD cohort, stratified according to age, sex and disease severities. To do so, ACHD patients were matched by age and sex with controls from the contemporary Copenhagen General Population Study


Eligibility Criteria:
Inclusion Criteria:

* Congenital heart disease
* BMI within the last five years

Exclusion Criteria:

* Without BMI or not congenital heart disease
Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

A prospective, observational cohort study designed to identify clinical phenotypes and evaluate predictors \& outcomes of functional mitral and tricuspid valve regurgitation in patients with atrial fibrillation.

Participant will under go:

* Baseline echocardiography
* Cpex Echocardiography
* Blood test: BNP
* 1 year follow up Echocardiography

Participants will be stratified into three subgroups:

* Atrial Functional MR
* Atrial Functional TR
* Mixed MR \& TR

Rationale

The natural history and risk factors for atrial valve disease are poorly understood and characterised. This study will examine differences between atrial mitral and atrial tricuspid disease and help us understand the natural history of these pathologies.

Study objectives

Primary objective

* Identify \& characterise phenotypes in functional mitral and tricuspid valve regurgitation
* Identify risk factors for progression of disease and outcome.

Secondary objective

Compare the three groups: atrial functional MR, atrial functional TR, and mixed disease, and identify any differences/similarities.

Primary endpoint

Effective Regurgitant Orifice Area at 1 year

Secondary endpoint

* Progression of valve disease defined as worsening of mitral or tricuspid regurgitation \> 1 grade at 1 year.
* Functional: New York Heart Association Class, Predicted VO2max (\<84%).
* Heart Failure admission within 1 year of recruitment.
* Mortality.

Recruitment will take place from the out-patient clinics \& echocardiography laboratory at St Bartholomew's Hospital

Eligibility Criteria:
Inclusion Criteria:

* Informed consent
* Age of 18 years or older
* Atrial fibrillation
* Moderate or severe atrial valve disease
* Adequate 2D echocardiography views including parasternal long axis, short axis, apical two chamber, apical three chamber and four chamber.

Exclusion Criteria:

* Unwilling or unable to give consent
* Left ventricular impairment (ejection fraction \< 50%).
* Primary/organic valve disease
A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing

The study will assess three different nebulizers for use in methacholine challenge testing in order to determine if the Aeroneb Solo would make a suitable replacement for the long-used and now obsolete Wright and Bennett-Twin nebulizers. Results from each device will be compared to evaluate whether current guidelines for the methacholine challenge should be updated for superior standardization.

Sixty asthmatics (20 at each testing site: University of Saskatchewan, McMaster University, Laval University) will be recruited to undergo this randomized, triple cross-over study. Three nebulizers will be tested, the Wright, the Bennett-Twin and the new Aeroneb Solo.

Breakdown of study procedure: Participants will undergo three (potentially four) methacholine challenges, one with each nebulizer in randomized order. An additional methacholine challenge may be performed for screening purposes if the participant has not undergone methacholine challenge testing in one of the participating labs in the previous 6 months. The screening challenge will be performed with the standard nebulizer used at the given testing site (i.e. the Wright or the Bennett-Twin).

The methacholine challenges performed with the Wright and Bennett-Twin nebulizers will follow the two-minute tidal breathing protocol as outlined in the 1999 American Thoracic Society Guidelines for Methacholine Challenge Testing. The testing protocol used with the Aeroneb solo will be identical save for a 1 min inhalation period instead of 2 min. Each challenge will be stopped when a participant's forced expiratory volume in 1 second (FEV1) drops at least 20%. This will allow for the determination of the participant's PC20 (provocative concentration of methacholine causing a 20% fall in FEV1), which will subsequently be converted to a PD20 (provocative dose) value. A minimum 24-hour washout period between challenges will be enforced.

Eligibility Criteria:
Inclusion Criteria:

* Men and women aged 18 or older
* Stable asthma
* Baseline methacholine PC20 less than or equal to 16mg/mL
* Baseline lung function greater than 65% predicted

Exclusion Criteria:

* Use of long-acting bronchodilators within 30 days of Visit 1
* Pregnant or nursing
* Cardiovascular problems
* Respiratory illness within 4 weeks of Visit 1
* Allergen-induced asthma exacerbation within 4 weeks of Visit 1
Drug Use Investigation for FLOLAN (Epoprostenol) Injection 0.5mg・1.5mg

The objective of this study is to evaluate the incidence of adverse events in Japanese pulmonary arterial hypertension subjects treated with epoprostenol injection based on prescribing information under the conditions of general clinical practice and also to grasp the following items;

1. Unknown adverse reactions (especially, significant adverse reactions)
2. Adverse reaction onset status under practical drug use conditions
3. Factors possibly influential on safety
4. Factors possibly influential on efficacy
5. Patient's prognosis, efficacy and safety in long-term use


Eligibility Criteria:
Inclusion Criteria:

* Subjects with cardiovascular disease

Exclusion Criteria:

* Subjects with hypersensitivity to epoprostenol
* Subjects with right cardiac failure during an acute exacerbation
* Subjects with severe left ventricular systolic dysfunction
* Subjects with serious left ventricular dysfunction
* Subjects whose pulmonary edema getting worse during dose initiation
Reducing Food Insecurity During COVID-19

This study aims to compare the effectiveness of two interventions to address food insecurity among low-income families with young children during the COVID pandemic. The investigators will conduct a parallel group, randomized controlled trial of 250 families. The first randomly assigned comparator is Fresh Connect, a produce prescription program that provides a stipend for participants to purchase fresh food items at mobile markets and independent farmers markets across Boston. The second comparator is grocery store gift cards, redeemable at conventional grocery stores. In each comparator, participants will be given the equivalent of $150 on a monthly basis for six consecutive months. All participants will be followed for 12 months to assess outcomes that involve food insecurity (primary), fruit and vegetable consumption, healthcare utilization, social service utilization, and physical/emotional health.


Eligibility Criteria:
Inclusion Criteria:

* Parent of a child 0-18 months of age
* Child receives care at Boston Medical Center

Exclusion Criteria:

* Planning to move residence outside of Boston within 12 months
i2TransHealth: Interdisciplinary, Internet-based Trans Health Care

i2TransHealth is a randomized controlled trial that investigates the outcomes of an internet-based health care approach for transgender and gender diverse (TGD) people. As a health services research project, i2TransHealth aims at reducing the structural disadvantage for TGD people \[people with transsexualism (TS: ICD-10), gender incongruence (GIC: ICD-11) and/or gender dysphoria (GD: DSM-5)\] living in areas lacking specialized transition-related treatment.

Located at the Institute for Sex Research and in cooperation with the Interdisciplinary Transgender Health Care Center Hamburg (ITHCCH), both University Medical Center Hamburg-Eppendorf (UKE), i2TransHealth is an innovative intervention including video consultation and a 1:1 chat with clinical psychologists. By cooperating with the ITHCCH, general physicians and psychiatrists provide first and local access to the specialized treatment provided by the UKE.

In the intervention group, the study participants are invited to use the i2TransHealth e-health platform including a video consultation hour every two weeks and a messenger between the video-meetings. In addition, they have the opportunity to receive medical support close to their home by licensed GPs and psychiatrists according to their needs (especially in case of a somatic or mental health crisis). The waiting group participants will be able to go forward with transition-related care after four months of study participation, as part of regular care.

The primary outcome measure is a reduced symptomatology for TGD people (BSCL). Secondary outcome parameters include quality of life and patient satisfaction as well as healthcare-related costs and cost-effectiveness. Finally, based on a longitudinal design, it will be assessed if the physicians improve their TGD-related expertise by cooperating within the i2TransHealth-network.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Gender different from their assigned sex at birth
* resident at least 50 km outside Hamburg
* present themselves with treatment needs (TS/GD) to one of the participating physicians in the i2TransHealth network, or direct contact with institute and/or e-health platform
* receive the suspected diagnosis TS/GD during an initial interview in the UKE
* can operate the video chat cognitively, verbally and auditory
* Able to read, speak, and understand German
* Written informed consent after written and oral information

Exclusion Criteria:

* Under 18 years of age
* Missing informed consent
* Unable to speak German
* Indication for inpatient treatment, e.g. due to acute psychotic symptoms (self-report, Prodromal Questionnaire, PQ-B) or severe depressive symptoms (self-report, BDI-II ≥ 29)
* Acute suicidal tendencies
* Decrease in intelligence (IQ below 70)
* Acute drug intoxication
* Failure to meet technical requirements (no Internet access, lack of IT knowledge)