cyrilzakka/clinical-trials huggingface dataset:
Compliance to a Hormone Therapy Regimen in Breast Cancer

RATIONALE: Understanding how well patients comply with their treatment regimen may help doctors plan the best treatment and ongoing care.

PURPOSE: This clinical trial is studying whether patients comply with their hormone therapy regimen in women with estrogen receptor-positive stage I, stage II, or stage IIIA breast cancer.

OBJECTIVES:

Primary

* To examine the relationship between adherence to endocrine therapy and variables from the Health Belief Model (i.e., perceived risk, barriers to and benefits of adherence, and cues to action such as physician recommendation) as well as measures of patient's perceptions of patient- and family-centered care in women with estrogen receptor-positive stage I-IIIA breast cancer.

OUTLINE: Patients complete a 15 minute questionnaire on-line or by mail comprising questions of demographic and medical variables (i.e., age, race/ethnicity, marital and educational status, and medication side effects) as well as health beliefs and selected aspects of patient- and family-centered care. Data collected from the questionnaire will be stored in an Excel database.

Patient's medical records are reviewed for information about the time since diagnosis, tumor characteristics, treatment, and comorbidity.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Women diagnosed with breast cancer

  * Stage I-IIIA disease
* Estrogen receptor (ER)-positive disease
* Must have begun prescribed hormonal therapy between December 2000 and December 2002
* No prior history of breast cancer

PATIENT CHARACTERISTICS:

* Female
* Menopausal status not specified
* Able to read and understand English

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* Prior breast surgery, axillary surgery, and radiotherapy to the breast or chest wall allowed
Effects of Upper Trapezius Stretching With and Without Mid Lower Trapezius Strengthening in Trapezius Myalgia

A Randomized controlled trial will be conducted. Non-probability convnience sampling will be used to collect the data. Sample size of 42 subjects with age group between 18 to 40 years will be taken. Data will be collected by using tools Numeric Pain Rate Scale (NPRS) for pain, Neck Disability Index (NDI) for disability and SF-36 for Quality of life. An informed consent will be taken. A total of 20 subjects will be selected by following inclusion and exclusion criteria and will equally divided in to two groups by random number generator table. Both groups will come thrice per week for a total of 4 weeks.

Trapezius myalgiais the complaint of pain, stiffness, and tightness of the upper trapezius muscle. It is characterised by acute or persistent neck-shoulder pain. In today's society, due to the increased use of computers, where the neck and shoulders are maintained in static abnormal postures to look at the computer screens and become vulnerable to cause neck pain. The aim of the study is to determine effects of upper trapezius stretching with and without mid lower trapezius strengthening exercises on pain, disability and quality of life in females with work related trapezius myalgia.

A Randomized controlled trial will be conducted in physiotherapy outpatient department of Bahria International Hospital Lahore. Non-probability convnience sampling will be used to collect the data. Sample size of 42 subjects with age group between 18 to 40 years will be taken. Data will be collected by using tools Numeric Pain Rate Scale (NPRS) for pain, Neck Disability Index (NDI) for disability and SF-36 for Quality of life. An informed consent will be taken. A total of 20 subjects will be selected by following inclusion and exclusion criteria and will equally divided in to two groups by random number generator table. Both groups will come thrice per week for a total of 4 weeks. The data will be analysed using SPSS software version 25. After assessing normality of data by Shapiro-Wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups.

Eligibility Criteria:
Inclusion Criteria:

* • Females between the age range of 18-40 years

  * Examination-Symptoms provoked by neck movement and palpation of Trapezius musculature.
  * Positive Trapezius Strength Test

Exclusion Criteria:

* Participants who present with dizziness and vertigo
* Infection or febrile state at the time of performing the test;
* Anxiety or extreme emotional tension;
* pharmacological treatment (analgesics, muscle relaxants, anxiolytics, antidepressants)
* Disc lesions
Molecular Screening for Lynch Syndrome in Denmark

A clinically applicably strategy for molecular screening for Lynch Syndrome is being implemented in Denmark.

Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling.

The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone.

Prospective data collection is performed using established clinical databases.


Eligibility Criteria:
Inclusion Criteria:

* Histological diagnosis of colorectal adenocarcinoma
* Diagnosed at one of the departments of pathology in Denmark

Exclusion Criteria:

* None
Pregabalin in the Prevention of Postoperative Delirium and Pain

The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves overall pain control.

Delirium is a common postoperative complication occurring in up to 73% of patients sometime during their hospital stay. Elderly patients undergoing major surgical procedures are at highest risk. While many risk factors for delirium are known, the specific pathophysiology of postoperative delirium remains unclear and is likely multifactorial. The most common inciting agents and events include metabolic causes, medications, blood loss, hypoxemia and pain. Pain and its management are intimately related to the likelihood of developing postoperative delirium. As a class, gabapentinoids, such as pregabalin, have proven to reduce postoperative pain and narcotic consumption and therefore may have a role to play in the prevention of postoperative delirium.

Eligibility Criteria:
Inclusion Criteria:

* aged 60 years and older
* booked for major orthopaedic or vascular procedure
* expected length of stay \> 2 days

Exclusion Criteria:

* open AAA repair
* EVAR
* allergy/sensitivity to pregabalin or gabapentin
* use of pregabalin or gabapentin in previous 14 days
* severe liver disease
* severe renal dysfunction defined as either having creatinine clearance \< 30 ml/min or being dialysis-dependent
* seizure disorder
* MMSE \< 24/30
* inability to speak English or French
Ocular Blood Flow Assessment in Glaucoma

Background : Glaucoma is a common disease, potentially blinding, characterized by progressive damage to the optic nerve. If the intraocular pressure is the most known risk factor, however, there are cases of glaucoma scalable despite well-controlled intraocular pressure, ocular hypertension without glaucoma or glaucoma without ocular hypertension (normal tension glaucoma).

Purpose :Involvement of vascular factors in the development of glaucoma and scalability has been proved, associated with a possible loss of vascular autoregulation. The objective of this study is to quantify MRI flow of blood flows referred ophthalmic patients with glaucoma untreated comparison with control subjects.

Eye vascularization, supplied by ophthalmic artery and superior ophthalmic vein is not easily accessible to routine explorations to date. Similarly the potential oscillations of the cerebrospinal fluid (CSF) around the optic nerve have not been described. Developments in magnetic resonance imaging (MRI) provide new insights into the quantitative study of blood and CSF flows through phase contrast MRI also called "flow MRI". Our hypothesis is that the ability of MRI to measure intracranial flow is applicable to the vasculature of the eye.

The MRI protocol will be applied to control adult subjects previously examined by an ophthalmologist. Structures to be imaged will be identified on a morphological sequence. Each MRI phase contrast slice (flow MRI) will be positioned perpendicularly to the flow direction. The flow MRI data will be analysed by a dedicated image processing tool which performs the vessels segmentation. For each curve of the vessel flow evolution during the cardiac cycle is reconstructed.

Glaucomatous patients will undergo a six-month follow-up to determine if they respond to their therapy.

Eligibility Criteria:
Inclusion Criteria:

* Adult participants
* Diagnosis of primary open angle glaucoma or normal-tension glaucoma
* Never received any anti glaucoma therapy
* Patients included in the group " normal pressure glaucoma " are patients where the diagnosis of optic neuropathy have been worn by the ophthalmologist with measured intraocular pressure \<21 mmHg.
* Healthy controls will be examined by an ophthalmologist before inclusion

Exclusion Criteria:

* Anyone with a classic contraindication to MRI
* Cardiovascular comorbidities or neurovascular : uncontrolled systemic hypertension , Diabetes, heart failure , carotid stenosis , ischemic stroke or transient ischemic attack.
* Already treated glaucoma
* Prescription by the ophthalmologist another treatment than prostaglandin analogue treatment.
* Other clinical forms of glaucoma : angle closure glaucoma, neovascular glaucoma, exfoliative glaucoma, secondary glaucomas, pigment dispersion glaucoma, traumatic glaucoma, congenital glaucoma
* Presence of other ocular pathology (simple refractive error allowing 10/10 of best corrected visual acuity and mild and moderate cataracts will not be considered as a criterion for non- inclusion).
* History of intraocular or orbital surgery of less than 6 months .
Magnetic Compressive Technique for Pancreatic Intestinal Anastomosis

In recent five years, the investigators have successfully developed different types of magnets and utilized in biliojejunostomy, concomitant biliojejunostomy and pancreaticojejunostomy during Whipple. This study is designed as a prospective study by utilization of the bar-like magnets for pancreaticojejunostomy.

Magnetic anastomosis has been attempted in continuous connection between bowel and bowel, vessels and vessels, biliary and gastrointestinal tracts, as well as in recanalization of the biliary stricture, and bilioenteric anastomotic stricture. During the past 15 years, the investigators have designed different types of magnets, and attempted these magnets in vascular, intestine, and biliary anastomosis in preclinical studies. In recent five years, we have successfully developed different types of magnets and utilized in biliojejunostomy, concomitant biliojejunostomy and pancreaticojejunostomy during Whipple. This study is designed as a prospective study by utilization of the bar-like magnets for pancreaticojejunostomy.

Eligibility Criteria:
Inclusion Criteria:

* Patients with pancreatic neoplasm who needs pancreatic head resection, or central pancreatectomy or partial pancreatectomy, and then pancreaticojejunostomy
* Patients with dilated pancreatic duct secondary to chronic pancreatitis who needs Frey's procedure
* Patients with pancreatic injury who needs pancreatic head resection, or central pancreatectomy or partial pancreatectomy, and then pancreaticojejunostomy

Exclusion Criteria:

* Woman during pregnancy or lactation or anyone with mental disorder
* The wall of pancreatic incision is too thick so that the attractive force of magnetic device cannot meet the requirements of compression
* Any foreign body has been implanted in body, such as heart pacemaker.
* Surgical contraindication, including Child-Pugh C with hepatic encephalopathy, and anyone with heart, lung, kidney dysfunction or other organ dysfunction, and cannot tolerate surgery
An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection

To restore immunologic function and virus-free state in HIV-infected patients. Based on previous studies showing temporary improvement in immune function in HIV-infected patients using peripheral lymphocyte transfers and bone marrow transplantation, and based on studies documenting the antiretroviral effects of zidovudine (AZT) and interferon-alfa (IFN-A) as well as the preliminary test tube and patient studies suggesting anti-HIV effects of recombinant CD4-IgG, we propose to treat HIV-infected patients using combination antiretroviral therapy with transplantation of bone marrow and peripheral lymphocytes from previously immunized donors in an attempt to restore immunologic function and a virus-free state.

Based on previous studies showing temporary improvement in immune function in HIV-infected patients using peripheral lymphocyte transfers and bone marrow transplantation, and based on studies documenting the antiretroviral effects of zidovudine (AZT) and interferon-alfa (IFN-A) as well as the preliminary test tube and patient studies suggesting anti-HIV effects of recombinant CD4-IgG, we propose to treat HIV-infected patients using combination antiretroviral therapy with transplantation of bone marrow and peripheral lymphocytes from previously immunized donors in an attempt to restore immunologic function and a virus-free state.

Three patients are treated with stable doses of AZT, IFN-A, and CD4-IgG for 12 weeks, followed by six peripheral lymphocyte infusions and transplantation of bone marrow from their respective identical twins. Following bone marrow transplantation, patients continue to receive the three drugs. Additional periods of lymphocyte apheresis and transfer may be offered to each donor/recipient pair.

Eligibility Criteria:
Inclusion Criteria

* Each patient must have an identical twin in a normal state of health with a normal screening lab panel and a normal immune profile who is documented to be antibody and culture and polymerase chain reaction (PCR) negative for HIV.
* Ability to provide informed consent.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

* Malignancy other than Kaposi's sarcoma.

Patients with the following are excluded:

* Unwillingness to comply with current NIH Clinical Center guidelines concerning appropriate notification of all current sexual partners of an individual regarding his or her positive HIV serostatus and the risk of transmission of HIV infection.
* Presence of a serious opportunistic infection or other illness or condition that, in the opinion of the principal investigator, warrants exclusion from participation in the study.

Current use of illicit drugs or significant amounts of alcohol that, in the opinion of the principal investigator, would interfere with compliance with the study.
Biofeedback-Based Cognitive Behavioral Treatment for Temporomandibular Disorders

The purpose of this study is to develop and evaluate a biofeedback-based cognitive behavioral treatment for patients with chronic temporomandibular disorders using a randomized controlled design.

The purpose of this study is to develop and evaluate a biofeedback-based cognitive behavioral treatment for temporomandibular disorders using a randomized controlled design. 100 patients suffering from chronic temporomandibular disorder are diagnosed using Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Subsequently, patients are randomly assigned to either a psychological intervention receiving 8 sessions of biofeedback-based cognitive behavioral treatment or to a dental intervention receiving interocclusal splint therapy.

Assessment takes place at baseline, after treatment approximately 8 weeks later, 3 and 6 months follow up. The effects of the interventions are evaluated in terms of reduction in pain intensity, pain related disability, psychological variables such as somatoform symptoms, depression and pain related cognitive adjustment as well as nocturnal electromyographic (EMG) activity.

Additionally, the study aims at identifying variables that predict treatment outcome. Further analyses include initial changes in treatment motivation and illness perceptions and its influence on treatment success, as well as changes in psychophysiological stress reactivity through treatment.

Eligibility Criteria:
Inclusion Criteria:

* clinical diagnosis of painful temporomandibular disorder according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)
* symptoms persist at least 3 months
* sufficient language skills

Exclusion Criteria:

* somatic diagnosis that requires defined somatic treatment (e.g. occlusal interference)
* presence of a psychotic disorder
* presence of neurological disorders (e.g. dementia)
* alcohol or substance abuse
* presence of other pain condition of predominant severity
Long Term Use Of Xalacom In Patients Glaucoma Or Ocular Hypertension

The objective of this Investigation is to evaluate the safety and efficacy of long-term treatment with Xalacom in medical practice. Also, occurrence of unknown and known adverse drug reactions (ADRs) in subjects treated with Xalacom will be monitored during the survey period, and whether an additional treatment outcome investigation and/or a post-marketing clinical study is required in the future will be determined.

All the patients whom an investigator prescribes the first Xalacom® should be registered consecutively until the number of subjects reaches target number in order to extract patients enrolled into the investigation at random.

Eligibility Criteria:
Inclusion Criteria:

* Patients need to be administered Xalacom® in order to be enrolled in the surveillance.

Exclusion Criteria:

* Patients not administered Xalacom®.
Long-term Follow-up Study of Lentiviral-based Gene-edited Immune Cell Therapy

According to health authorities guidances (FDA 2006, EMA(European Medicines Agency) 2009) for gene therapy clinical trials, observing subjects for delayed adverse events for 15 years is recommended. This purpose of this long-term follow-up study is to evaluate the safety and efficacy in patients who have ever received lentiviral-based gene-edited immune cells which are manufactured by Pell Bio-Med Technology Co. Ltd.

After completion or early withdraw from the other treatment protocol, patients should be enrolled into this long-term follow-up study. If patients do not enter this study right after leaving the treatment protocol, they may have the option to enter this long-term follow-up study at any time within 15 years after the last lentiviral-based gene-edited immune cell infusion.

Eligibility Criteria:
Inclusion Criteria:

1. Patients must have ever received Pell's lentiviral-based gene-edited immune cell as monotherapy or as combination therapy in clinical trials.
2. The last lentiviral-based gene-edited immune cell infusion within 15 years.
3. Patient/patient's parent/legal guardian is capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

Exclusion Criteria:

There are no specific exclusion criteria for this study.
Clinic-based and Tele-monitored Home-based Intervention in Patients With Knee OA

This study assessed and compared the effects of clinic-based and telemonitored home-based interventions on pain intensity, function and quality of life in patients with knee osteoarthritis (KOA). This was with a view to providing evidence for the validation of the effectiveness of home-based intervention on knee osteoarthritis

This study was a quasi-experiment involving forty two patients with KOA. They were randomly allocated into two groups equally; clinic-based group (CBG) and telemonitored home-based group (THG).

The CBG received exercises to strengthen the quadriceps and hamstring muscles using thera band while THG received same treatment regimen but at home and were monitored on phone by the researcher. The subjects performed four sets of eight repetitions for each of the exercises three days in a week for eight weeks. Pain intensity was assessed with Quadruple Visual Analog Scale, function was assessed with the Western Ontario and McMaster University Osteoarthritis Index and quality of life was assessed with WHO Quality of Life-BREF at pretreatment, 3rd week, 6th week and 8th week of intervention. Data was analysed with descriptive and inferential statistics. Repeated measure ANOVA was used to compare the mean value of variables within the group and between the groups. Alpha level was set at 0.05.

Eligibility Criteria:
Inclusion Criteria:

* Patients diagnosed with osteoarthritis of the knee of not less than six weeks.
* Patients that have means of communication via mobile telephone.
* Patients who understands English or Yoruba Language.

Exclusion Criteria:

Participants that have any other knee joint diseases.

* Participants with history of knee joint trauma.
* Participants with history of knee surgery or arthroplasty
Evaluation of Internet-Based CME for Wet-cupping Providers

A randomized controlled Trial to evaluate the internet based CME for wet cupping providers in Saudi Arabia

Research problem:

Complementary and Alternative Medicine (CAM) is widely used in Saudi Arabia. As wet-cupping practice regulation and licensing had been established the need increased to develop a system of Continuing Medical Education (CME) for wet-cupping providers. E-learning grown steadily to become a popular approach in medical education with the fast-evolving technologies made it possible to develop and implement a high-quality Internet-based CME. The aim of this study is to compare the effectiveness of Internet-based CME with conventional CME in the field of complementary medicine.

Research Significance:

Aiming to control the training to guarantee evidenced-based quality care while facing the challenge of increased number of licensed cupping providers who needs CME hours to maintain and improve their practice. There is a need for a study to evaluate if the internet-based technique can help overcome the challenge and to increase the number and improve the quality of CME activities.

Research Objectives:

To evaluate the effect of internet-based CME activity on knowledge, knowledge retention and intellectual skills in wet-cupping providers compared with conventional CME activity. Moreover, to develop a model of a blended CME activity using the online platform to conduct a flipping classroom CME activity in complementary medicine.

Research Methodology:

Randomised, open, comparative controlled trial. Participants will be selected from a list of the registered cupping providers. Using a list of registered cupping providers (sample frame) a sample will be selected randomly using computer generated number. After taking informed consent participants will be allocated randomly into three groups; 1) Internet-based CME activity group; 2) Conventional CME activity group, and 3) control group (waitlist) receiving no intervention. Data will be explored for distribution, and the appropriate methods of presentation and testing of differences will be selected accordingly. Two-tailed values of p\<0.05 will be considered statistically significant. Immediate knowledge score, Retention Knowledge rate and skills score will be compared within and between the groups.

Eligibility Criteria:
Inclusion Criteria:

* Physicians, nurses, physiotherapists
* Passed the Compulsory wet cupping training course within the last three years.
* Available during the study periods.

Exclusion Criteria:

* Unaccredited wet cupping training courses.
* Accredit courses more than three Years