cyrilzakka/clinical-trials huggingface dataset:
Physical Exercise, Nutrition Supplement and Frailty of Older Population

This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.

Objective: This study is aimed to explore the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life in community-dwelling older population.

Methods: We conduct a quasi-experimental study to measure frailty, depressive symptoms, and quality of life before and after intervention. A total of 120 community-living older adults with frailty identified by Fried's phenotype method are assigned to four groups: physical exercise group, nutrition supplements group, physical exercise and nutrition supplements group, and control group. Each participants in the assigned group will receive 12 weeks intervention. Measurements include frailty (Fried's phenotype method), depressive symptoms (Geriatric Depression Scale-15, GDS-15), and quality of life (WHOQOL-BREF). Data analyses include describe statistics, Chi-square test, and Analysis of Variance. A Generalized estimating equations (GEE) will be used to examine the effect of physical exercise and nutrition supplement on improving frailty, depressive symptoms, and quality of life.

Eligibility Criteria:
Inclusion Criteria:

* older adults aged more than 60 years;
* pre-frail stage: must have one item as frailty identified using the Fried's phenotype method;
* normal cognition: AD8 score less than 2 points;
* can communicate with Mandarin or Taiwanese.

Exclusion Criteria:

* incapable of walk independent or using assistive devices (e.g., crutches);
* a condition of having an acute disease, hemodialysis, or unable to engage in physical activity;
* have history of unstable heart disease such as coronary heart disease, heart failure and hypertension without regular medication;
* have regular physical activity (≥150 minutes weekly) such as aerobic dance, swimming, Tai Chi.
A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Subjects

This study will assess the safety and tolerability of a single dose of 13-valent Pneumococcal Conjugate Vaccine for approximately 1 month after vaccination sequentially in healthy Chinese adults aged 18 through 55 years, followed by children aged 3 through 5 years, and then infants aged approximately 2 months.


Eligibility Criteria:
Inclusion Criteria:

1. Age at the time of enrollment is:

   * 18 through 55 years (before the fifty sixth birthday) for Group 1.
   * 3 through 5 years (before the sixth birthday) for Group 2.
   * 42 to 98 days for Group 3.
2. Healthy subject as determined by medical history, physical examination, and judgment of the investigator.

Exclusion Criteria:

* Previous vaccination with licensed or investigational pneumococcal vaccine.
* Previous anaphylactic reaction to any vaccine or vaccine-related component.
* Contraindication to vaccination with pneumococcal vaccine.
Dietary Patterns and Cardiovascular (CVD) Risk in Spinal Cord Injury (SCI) Factors In Individuals With Chronic Spinal Cord Injury

This study will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. The study is a supplement to the Coronary Artery Risk Development in Young Adults (CARDIA) study. The dietary history from CARDIA will be used. The investigators' primary hypothesis is the following: Greater whole-grain and dietary fiber intake will be favorably associated with adiposity (BMI and WC) and metabolic CVD risk factors (fasting glucose, fasting insulin, HOMA-IR, diabetes, hsCRP, TC, HDL-C, triglycerides, TC/HDL-C ratio, non-HDL-C, and systolic and diastolic blood-pressure) among a sample of individuals with SCI aged 38-50 who have been injured \>1 year.

This study is a cross-sectional study. It will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. The study is a supplement to the Coronary Artery Risk Development in Young Adults (CARDIA) study. The dietary history from CARDIA will be used. The investigators' primary hypothesis is the following: Greater whole-grain and dietary fiber intake will be favorably associated with adiposity (BMI and WC) and metabolic CVD risk factors (fasting glucose, fasting insulin, HOMA-IR, diabetes, hsCRP, TC, HDL-C, triglycerides, TC/HDL-C ratio, non-HDL-C, and systolic and diastolic blood-pressure) among a sample of individuals with SCI aged 38-50 who have been injured \>1 year.

Eligibility Criteria:
Inclusion Criteria

* Male or female, black or white with SCI due to a nonvascular insult that caused an acute spinal cord injury (i.e. traumatic injury, transverse myelitis without a diagnosis of multiple sclerosis, surgical complication, or benign neoplasm) at least 1 year prior to enrollment including ASIA A,B,C
* Age at time of enrollment: \> 38 years and \<55 years (i.e., on or after 38th birthday and before 55th birthday)
* Voluntary, informed consent of participant
* Participant willing to comply with the testing protocols and questionnaires
* Communication and comprehension sufficient for compliance with all testing procedures and measures Exclusion Criteria
* SCI of a vascular or malignant etiology
* Pregnancy, end-stage renal disease, treatment for cancer except for non-melanoma skin cancer in the past five years
* Injury \< 1 years prior to enrollment
* ASIA D
* Chronic, nontobacco substance-abuse
Aerobic and Strength Training With Caloric Restriction on Insulin Resistance in Obese Premenopausal Women

A total of 42 premenopausal women diagnosed clinically as having insulin resistance. Their ages ranged from 35 to 45 years old; their body mass index was \>30 kg/m2 and They were obese women complained of insulin resistance and non diabetic or cardiovascular disease, were randomly assigned to group A participated in aerobic \& resistive exercise program, and group B participated in aerobic exercise and followed prescribed diet restriction program. Both of the groups (A\&B) followed the treatment program 3 times per weeks for 8 weeks. Assessment of the fasting glucose, fasting insulin, and HOMA test of insulin resistance were measured for all subjects in both groups (A and B) was carried out before and after the end of the treatment program

Forty two obese premenopausal women diagnosed as having insulin resistance were participated in this study. They were selected randomly from the out Patient Clinic of Obstetrics at Kasr El Ainy University Hospital, Faculty of Medicine, Cairo University. Their age ranged from 35 - 45years, their body mass (BMI) were\>30kg/m2. Exclusion criteria of the study were as follows: Patients having diabetic or cardiovascular disease, Patients with life threatening disorders as renal failure and myocardial infarction, Patients with active malignancy and patients with severe hemorrhage, hyperthyroidism, acute viral diseases and mental disorders. Participants were assigned randomly used sealed envelope into two groups (A\&B) equally in number. Group (A): (Combined resistive and aerobic exercise group) consisted of 20 women were participated in aerobic \& resistive exercise program plus diet restriction, 3 times per weeks for 8 weeks. Group (B): consisted of 20 women were participated in aerobic exercise plus diet restriction 3 times per weeks for 8 weeks.

Eligibility Criteria:
Inclusion Criteria:

* Their age ranged from 35 - 45years.
* their body mass (BMI) were\>30kg/m2.

Exclusion Criteria:

* Patients having diabetic or cardiovascular disease.
* Patients with life threatening disorders as renal failure and myocardial infarction
* Patients with active malignancy.
* patients with severe hemorrhage
* hyperthyroidism.
Animation Education Program Applied to Laparoscopic Sleeve Gastrectomy Patients

Objectives This study investigated the effect of animation education developed for respiratory rehabilitation among sleeve gastrectomy patients on patient care results.

Design This is a randomized controlled study. Method A total of 66 patients who were going to have sleeve gastrectomy were randomly divided into two groups each including 33 participants. The intervention group was provided with animation education. The control group received routine face-to-face education. Postoperative risk of respiratory complications, presence of dyspnea, nausea, and vomiting, frequency of postoperative respiratory exercises, and satisfaction with postoperative respiratory education were examined. Patients' pain and sleep quality were examined one day before the surgery and on the postoperative first and fifth days.


Eligibility Criteria:
Inclusion Criteria:

The patients,

who are in clinical treatment for sleeve gastrectomy; who are 18 years of age or older, mentally healthy; who can speak and understand Turkish; who owns and can use smartphones; who do not have chronic diseases related to the respiratory system (lung diseases, etc.); who are volunteers, will be included in the study.

Exclusion Criteria:

The Patients

who are a lung infection in the last month who are neurological disease who are major psychiatric diagnosis who are vision and hearing problems who are intolerable dyspnea who do not agree to participate in the study, will be excluded
Description of Lymphatic Damage in Encephalic Venous Thrombosis and Strictures in MRI a Reverse-recovery Sequence: a Pilot Study

Inclusion (J0):

* Information
* Verification of inclusion and non-inclusion criteria
* Collection of consent
* MRI examination with injection of contrast product as part of the treatment comprising the sequences:

T1 TFE 1.0 iso 3D FLAIR injected Injected elliptical venous angiography 0.4mm iso or less 3D SWIp multiecho 3D T1 injected FABIR iso without injection (added as part of care in case of suspected ASH or meningitis) FLAIR 1.0 without injection (added as part of care for suspected ASH or meningitis) T2 BFFE XD (added by search) FABIR iso injected (added by research) 3D PD T1 0.55 MSDE iso injected (added by research)

Clinical information (SRM on inclusion, on discharge and at 3 months and recurrence within the year) will be collected from the patient's medical file


Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years of age
* Performing an MRI injected as part of care for one of the following reasons:
* suspicion of pathology likely to be associated with narrowing or obstruction of one or more venous sinuses (cerebral thrombophlebitis, tissue damage with venous extension, idiopathic HIC
* venous narrowing or obstruction proven by one of the above pathologies, requiring as part of routine care an injected MRI (search for impact, monitoring, pre-therapeutic assessment or prognosis)
* Express consent to participate in the study
* Affiliate or beneficiary of a social security scheme

Exclusion Criteria:

* Absolute contraindication to MRI
* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman
Bicarbonate in Patients With Out-of-hospital Cardiac Arrest

A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.


Eligibility Criteria:
Inclusion Criteria:

* adult cardiac arrest patient with arterial pH \<7.1 or bicarbonate \<10mmEq/L checked at 10 minutes of cardiopulmonary resuscitation

Exclusion Criteria:

* age \<18 trauma patient Do Not Resuscitate state
Testing MST to Improve Adherence Among Youth With Chronic Poor Metabolic Control

The protocol is a randomized clinical trial providing Multisystemic Therapy (MST), an intensive home-based family psychotherapy intervention, to a group of urban adolescents with poorly controlled Type 1 diabetes and their families.

Substantial data exists to demonstrate that improving metabolic control in persons with Type 1 diabetes mellitus (T1DM) can delay the onset of diabetes complications and reverse some existing complications as well. Unfortunately, those adolescents with T1DM who are at highest risk for diabetes complications are often the most resistant to hospital based care and traditional education/ supportive interventions. They are also faced with multiple barriers to improved metabolic control, which may include lack of knowledge about diabetes, family disorganization and disengagement, high levels of stress and an unhealthy lifestyle. Multisystemic Therapy (MST), a flexible and home-based therapeutic intervention originally designed for use with mental health populations, seems to be a promising approach to providing diabetic adolescents with the ability to engage in consistent and attentive illness management.

The study recruited a sample of 127 adolescents in poor metabolic control and randomly assigned them to either the treatment intervention, MST plus standard medical care, or standard medical care alone. Families randomized to MST received intensive, home-based family therapy for approximately six months. Families completed data collection at baseline and then again at 7, 12 18 and 24 months after study entry.

Eligibility Criteria:
Inclusion Criteria:

* a current hemoglobin A1c(HbA1c) of \>8.0%
* an average HbA1c of \>8.0% during the past year
* diagnosed with Type 1 diabetes for at least one year
* reside in the metro Detroit tri-county area

Exclusion Criteria:

* severe mental impairment/thought disorder
* non-English speaking patient/parent
* co-morbid major medical condition such as cystic fibrosis
Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation

A prospective comparative randomized single-centre non-inferiority trial. The purpose of this study is to compares of modified method of eversion carotid endarterectomy with standard eversion carotid endarterectomy for 3,6 and 12 months days after operation in patients with extensive atherosclerotic disease of carotid bifurcation

Introduction. Performing eversion endarterectomy some difficulties arise. Firstly, it requires a great deal of coherence between the work of the surgeon and the first assistant, as well as a great experience of the latter. Secondly, in some cases, there are difficulties in visualizing the distal margin of the intima: in the absence of a rigid skeleton, the soft unchanged artery walls after removal of the plaque subside, making it difficult to visualize possible fragments of the intima. Thirdly, the cost of the error is high: with a random de-version, repeated eversion turns out to be impossible. It should be noted that the use of an eversion technique becomes difficult to implement, and sometimes impossible, with extended stenosis, since a very high allocation of the ICA is required, which increases the invasiveness of the operation and the difficulty of access. With prolonged stenosis, the carotid endarterectomy remains the option of choice. The modification used eversion carotid endarterectomy combines the advantages of both methods, and also eliminates the limitations of the carotid endarterectomy and eversion carotid endarterectomy.

The aim of study. The purpose of this study is to compares of modified method of eversion carotid endarterectomy with standard eversion carotid endarterectomy for 3,6 and 12 months days after operation in patients with extensive atherosclerotic disease of carotid bifurcation

Eligibility Criteria:
Inclusion Criteria:

* patients with stenosis of ICA 70-99% (ultrasound - NASCET and CT angiography)
* patients with a extensive lesion of the ICA (plaque \< 2 cm) by ultrasound - NASCET and CT angiography

Exclusion Criteria:

* patients with a extensive lesion of the ICA (plaque \< 2 cm),
* patients with a contralateral occlusion of the ICA
* patients with stroke in ischemic type in the acute period.
Investigation of Spinal Health and Internet Addiction of Individuals Working Remotely

Low back pain and neck pain are common problems that affect people at certain times in their lives. These people constitute a significant part of the disease burden due to their recurrent complaints. People with low back and neck pain often seek medical attention. This situation causes individuals to apply to the hospital frequently and causes a serious cost at the social level.

When the risk factors for neck pain are examined, many factors such as genetics, sleep problems, smoking, obesity, sedentary lifestyle, poor posture, previous neck pain, trauma, back pain and poor general health cause neck pain to develop. Similarly, conditions such as age, obesity, and poor general health appear to be risk factors for low back pain. In addition to these risk factors, it has been reported that occupational factors such as long and sedentary working hours and unsuitable workplace conditions may also cause low back and neck pain. Fixed posture and prolonged sitting are thought to be risk factors for low back and neck pain, but opinions on this subject are not clear.

The COVID-19 pandemic has created a global crisis since 2019 and caused a change in the lifestyle of all people around the world. The World Health Organization (WHO) stated that social distance should be increased and face-to-face contact should be reduced to prevent the spread of the pandemic. For this reason, many institutions have decided to work remotely and trainings have been carried out remotely. The increasing teleworking style with the COVID-19 pandemic has led to an increase in the average screen time of individuals. It was reported that time spent on the Internet increased by 52% compared to the pre-pandemic period.

This study aims to investigate the relationship between increased teleworking hours and internet use during the pandemic period in individuals with low back or neck pain. Researchers think that postural changes that may occur with increased distance working time, increased fixed posture and asymmetrical loading may contribute to the uncertain relationship between low back and neck pain and posture.


Eligibility Criteria:
Inclusion Criteria:

* Working online during the pandemic process,
* Have a smart phone,
* Agree to voluntarily participate in the research.

Exclusion Criteria:

* Have a malignant condition,
* Loss of function due to neurological or systemic disease,
* Having had a surgical operation in the last 6 months,
* Have an unhealed fracture,
* Withdraw consent at any stage of the study.
Assessment of the Effect of Empagliflozin (BI 10773) as Single Dose on the QT Interval in Healthy Female and Male Subjects

The objective of this study is to demonstrate that BI 10773 does not prolong the QT(c) interval more than placebo


Eligibility Criteria:
Inclusion criteria:

healthy female and male subjects
Upper Body Plyometrics in Junior Male Cricket Fast Bowlers

A six-week upper body plyometric training program will be used to investigate its impact on fast bowling speed in junior male cricket players in Guyana, using a Stalker Sport 2 radar gun.

This randomized pilot study will compare the effects of a six-week Upper Body Plyometric program with Upper Body Strength Training. After gaining ethical approval and baseline bowling speeds recorded, thirty under 19 club level fast bowlers will be assigned to two groups to complete either an upper-body plyometric or strength training program. Each group will participate in three (3) supervised exercise intervention sessions per week. Each 65-minute session will consist of a warm-up and cool-down program in addition to specific and routinely progressed upper body exercises as per each group's protocol. At the end of the intervention period, their bowling speeds will again be measured using a Stalker Sport 2 radar gun.

Eligibility Criteria:
Inclusion Criteria:• Only male athletes were admitted to the study.

* Athletes must have been practicing the art of fast bowling for at least one year at the club level.
* Athletes must have been between the ages of 15-19.
* Athletes must have been uninjured at the time of commencement of the study.

Exclusion Criteria:

* • Were outside of the age group being surveyed at the time of the study,

  * Had been practicing fast bowling at the club level for less than one (1) year,
  * Was injured at the time of commencement or within one year of the study.
  * Could not commit to full participation in the study's training regimes.
  * Received surgery in the three years prior to the study or had undergone rehabilitation within the past year.
  * Were currently engaged in plyometric training as this may confound the study.
Ultrasound Guided Thoracic Paravertebral Block for Percutaneous Nephrolithotomy Operations in Children

The investigators aimed to evaluate the effect of ultrasound guided thoracic paravertebral block with bupivacaine on both perioperative anesthetic agent consumption and postoperative analgesia in pediatric patients undergoing percutaneous nephrolithotomy for kidney stone.

This study was performed after approval of Ethics Committee and parents written consent. Between the ages 1-5, planned percutaneous nephrolithotomy due to kidney stones 40 patients were enrolled in this study, and patients were randomly divided into two group. All patients were performed general anaesthesia. The Group I patients was given ultrasound guided thoracic paravertebral block with 0.5 ml/kg bupivacaine %0.5 after giving prone position and the Group II patients was given 15 mg/kg of paracetamol as postoperative analgesia. In the period of postoperative, if the FLACC \> 4; it was planned to dose 1 mg/kg of tramadol. Patients' hemodynamic parameters, oxygen saturation, sevoflurane concentration were recorded 10, 15, 30 and 60 minutes intraoperatively. Patients' hemodynamic parameters, oxygen saturation, pain scores (FLACC), satisfaction of parents, the number of patients who additional analgesic requirements and side effects (nausea,vomiting, hypotension, bradycardia, respiration problems etc) were recorded in the postoperative period. Primary outcome measures was pain scores using FLACC scale.

Eligibility Criteria:
Inclusion Criteria:

* ASA physical status I-II
* Between the ages of 1-5 years
* Forty children

Exclusion Criteria:

* Refusals by parents
* Children with spine deformities
* Cutaneous infection
* Bleeding diathesis
* Allergy to drugs used
* ASA physical status III-IV