cyrilzakka/clinical-trials huggingface dataset:
Objective Assessment of Physical Activity in Older Adults

The purpose of the present study is to evaluate the validity of 2 objective measures of physical activity among older adults. In addition, the investigators will examine the influence of functionality, walking aids, walking speed and step length on the accuracy.


Eligibility Criteria:
Inclusion Criteria:

* \> 70 years

Exclusion Criteria:

* recent cardiovascular event
* vestibular disorder or fracture (4 months)
* severe dementia
* oxygen supplementation during daily activities
* not able to perform daily activities
Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia

RATIONALE: Studying bone marrow samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying biomarkers in samples from young patients with acute myeloid leukemia.

OBJECTIVES:

* To compare the frequency of germline telomerase mutations in pediatric patients with acute myeloid leukemia (AML) demonstrating prolonged myelosuppression, defined as ≥ 1 episode \> 35 days of neutrophil count recovery after chemotherapy, to the pediatric patients with the expected myelosuppression, defined as consistently \< 35 days of neutrophil count recovery after chemotherapy.
* To assess association between telomerase mutations and incidence of grade 3 or 4 mucositis, relapse, and death.
* To compare germline (remission) telomere length in pediatric AML patients demonstrating delayed bone marrow recovery with the pediatric patients with consistently expected recovery.
* To assess whether a correlation between telomere length and incidence of grade 3 or 4 mucositis, relapse, and death exist.

OUTLINE: This is a multicenter study.

Cryopreserved bone marrow samples are analyzed for DNA sequencing and mutation by Sanger-based sequencing methods, quantitative PCR, and SeqMan Pro (Lasergene from DNAStar). Results are then compared with previously published data and existing databases to determine the allele frequency in control populations.

Eligibility Criteria:
DISEASE CHARACTERISTICS:

* Diagnosis of acute myeloid leukemia
* Enrolled on CCG-2961 and meeting 1 of the following criteria:

  * More than 35 days to recover to an ANC \> 500/mm³ after any course of chemotherapy
  * Consistently recovered \< 35 days to an ANC \> 500/mm³ after all courses of chemotherapy
* Available cryopreserved cell from diagnostic and end-of-therapy samples

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
Efficacy of Osteopathic Visceral Treatment in Patients With Chronic Neck Pain

This study aims to analyze the effects of visceral osteopathic treatment of the diaphragm, stomach and liver in the treatment of chronic neck pain.

Cervical pain is a very common condition, whom can originate from bad posture, cervical tension, anxiety, depression and occupational or sportive activities. The influence of mobility and function changes of the abdominal viscera in the cervical region is a mechanism that is still poorly described in literature.

It is expected to find, through mechanical and neural pathways, that the visceral osteopathy treatment will have some effect on chronic neck pain.

This study intends to check the effects of the diaphragm stretching, inferior mobilization of the stomach and liver pump techniques (restoring mobility and normalizing function of the viscera) on the neck region, by employing some questionnaires/instruments.

During the present study, the effects of the visceral techniques will be analyzed in the following variables: Neck Disability Index (NDI), Numeric Pain Scale (NPS or END) and Global Pain Scale (GPS or EPGM).

Eligibility Criteria:
Inclusion Criteria:

* Pain in the posterior cervical region for more than 3 months;
* Knowing how to read and write;

Exclusion Criteria:

* Recent Cervicothoracic or Thoracoabdominal trauma (less than 6 months);
* Surgical procedure in the cervical region less than 6 months ago
* Surgical procedure in the abdominal region less than 6 months ago;
* Diagnosis of disc disease/radiculopathy;
* Rheumatic and/or neurological disease;
* Pregnancy status
Iron Absorption from Lipid-Based Nutrient Supplements

The overall objective of this study is to determine dietary iron absorption from lipid-based nutrient supplements (LNS) in apparently healthy and undernourished children. This case-control study will recruit apparently healthy children and children with uncomplicated undernutrition (age 1-3 years, n=15/group) from Msambweni and the surrounding rural communities in Kwale County, Kenya. At the baseline visit (day 0), participants will be provided with an LNS labeled with a stable iron isotope (57-Fe). Participants will return to the hospital 14 days later (day 14) for a blood draw. Blood collected on day 14 will be used to measure iron isotope incorporation into red blood cells. Blood collected at screening will be used to measure indicators of anemia, iron status, hepcidin, and inflammation.


Eligibility Criteria:
Inclusion Criteria:

* Children age 1-3 years on day of screening visit
* Hemoglobin 8-11 g/dL on day of screening visit
* Undernourished \[length/height-for-age z-score (HAZ), weight-for-age z-score (WAZ), and/or weight-for-height/length z-score (WHZ) \< -2\] OR apparently healthy (HAZ, WAZ, and/or WHZ ≥ -1)

Exclusion Criteria:

* Severe acute malnutrition (WHZ \< -3) with no appetite
* Serious medical condition or other chronic disease besides undernutrition (e.g., HIV+, severe pneumonia, malaria)
* Peanut allergy or other allergy that prevents consumption of the LNS
* Plans to move away from the study location during the study period
Addressing Barriers to Palliative Care Use in Bladder Cancer

Investigators plan to establish an in-depth understanding of knowledge and beliefs about palliative care in advanced Bladder Cancer patients and their caregivers, and to identify factors associated with positive and negative experiences with palliative care services among those who have received them.


Eligibility Criteria:
Inclusion Criteria:

* Eligibility for both patient and caregiver participants will include:
* age ≥18 years
* able to speak and read English
* cognitively able to participate in study tasks
* willing to participate in surveys, semi-structured interviews, and/or focus groups
* able to participate in either a Zoom meeting or phone interview
* able to complete an emailed or paper survey
* Patient Participants: a diagnosis of muscle-invasive or locally advanced bladder cancer (stages II-IV).

Exclusion Criteria:

* Patients and caregivers will be excluded if unable to provide verbal or written consent
Hyperbaric Oxygen Therapy Improves Brain Function in Patients With Cognitive Decline After COVID-19 Infection.

COVID-19 has swept the world, and while some people may experience long-term cognitive decline as a result of infection, no effective treatment has been announced. The primary goal of this study was to determine the efficacy of hyperbaric oxygen therapy in patients with SARS-CoV-2 infection, as well as to assess the effect of hyperbaric oxygen therapy on brain function in patients with COVID-19-related cognitive decline. In this study, approximately 80 people were randomly assigned to either hyperbaric oxygen or regular oxygen therapy to compare the effects of these two treatments on disease.

80 patients with cognitive impairment following a novel coronavirus infection will be randomly assigned to one of two treatment groups: hyperbaric oxygen therapy or conventional oxygen therapy.

After the intervention, the improvement of hyperbaric oxygen on cognition, fatigue, sleep disorders, anxiety and depression, and other clinical manifestations was observed. The neurologic function of hyperbaric oxygen in the treatment of patients with cognitive decline after SARS-CoV-2 infection was also evaluated from imaging and electrophysiological multi-dimensional indexes.

Eligibility Criteria:
Inclusion Criteria:

* Out-patients 4 weeks after the diagnosis of SARS-CoV-2 infection
* Subjective cognitive decline after SARS-CoV-2 infection
* SARS-CoV-2 nucleic acid/antigen test negative.

Exclusion Criteria:

* Contraindications to hyperbaric oxygen therapy
* Cognitive decline can be explained by other diseases
* Conditions that researchers consider unsuitable for clinical trials.
Switching Study From Lamivudine to Clevudine in the Chronic Hepatitis B Patients

A multi-center and open study to compare the safety and effectiveness of switching treatment from lamivudine to clevudine for 24 weeks.


Eligibility Criteria:
Inclusion Criteria:

* HBV DNA \> 2,000 copies/mL at screening
* Patients who have compensated liver disease (Child-Pugh score =\<6)
* Patients without LMV resistant mutation by RFMP assay
* Patients who have NOT experienced viral breakthrough at consecutive two measurements (at least one month apart) during lamivudine monotherapy
* Patients who can submit the written consent and comply with the claims postulated of this clinical trial

Exclusion Criteria:

* Currently receiving antiviral except LMV or corticosteroid therapy
* Patients that previously received antiviral treatment for hepatitis B other than lamivudine in the proceeding 12 months
* Previous treatment with interferon or other immunomodulatory therapies must have ended at least 6 months preceding the study screening
* Treatment with nephrotoxic drugs, competitors of renal excretion, and/or hepatotoxic drugs within 2 months before study screening or during the study period
* Patients who is co-infected with HCV, HDV or HIV
* Serious concurrent medical conditions
* Prior organ transplantation
* Patient has creatinine clearance less than 60mL/min as estimated by the following formula:

\[(140-age in years) (body weight \[kg\])\] / \[(72) (serum creatinine\] \[mg/dL\])\[Note: multiply estimates by 0.85 for women\]
Clinical and Radiological Effect Of Platelet Rich Fibrin on the Healing of Periodontal Intrabony Periodontal Defects

The aim of this split mouth, single-center, controlled study is to compare the healing of intrabony defects treated with a combination of Anorganic Bovine Bone Mineral (ABBM)/Platelet Rich Fibrin (PRF) or Anorganic Bovine Bone Mineral alone. The hypothesis being tested in the study was that PRF would augment the regenerative effects of ABBM in human intrabony defects.

Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intrabony defects. Platelet rich fibrin (PRF) is a new generation platelet concentrate with a simplified technique. Although there are some studies on the use of PRF in the treatment of intrabony defects, to date none of them evaluate its additive effects with ABBM. Therefore, a randomized, split mouth clinical trial was conducted to compare the healing of intrabony defects treated with a PRF/ABBM combination and to those obtained with ABBM alone. Using a split mouth design, 15 paired intrabony defects were randomly treated with either ABBM alone (control group) or with ABBM- PRF combination (test group). The following clinical parameters and radiographic measurements were recorded at baseline and six months postoperatively: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, the depth of the defect and defect angle

Eligibility Criteria:
Inclusion Criteria:

* no systemic diseases;
* a good level of oral hygiene (OH) (plaque index\<0.15);
* presence of two paired two-wall or three-wall intrabony defects with probing depth ≥6mm and an intrabony component ≥3mm as detected on radiographs; -no intrabony defects extending into the furcation area;
* tooth mobility ≤1;
* tooth and adjoining teeth testing vital and without symptoms or signs of endodontic involvement;
* tooth and adjoining teeth free of caries or inadequate restorations.

Exclusion Criteria:

* patients with compromised immune systems;
* pregnant and/or lactating women;
* patients taking any drug known to affect the periodontal status or affect the coagulation system
* smokers.
Outcome and Prognostic Factors of Surgical Management of Scalp AVMs.

Scalp arteriovenous malformations (AVMs) are rarely encountered vascular scalp anomalies that represent 8% of all AVMs. Different terms are being used to describe the vascular anomalies of the scalp include cirsoid aneurysm, racemosum aneurysm, plexiform angioma, arteriovenous fistula and arteriovenous malformation. Derived from the Greek language, kirsos, the term cirsoid aneurysm is used to describe the AVM as it resembles varix. Case studies reported approximately 200 cases with increased prevalence during the last 15 years. The etiology of scalp AVMs remains controversial, it can be spontaneous or traumatic. They generally develop in the trauma background and in patients over 30-year-old while spontaneous scalp AVM may present at birth and remains asymptomatic until adulthood.

Patients with scalp AVMs are usually presented with scalp swelling, and cosmetic concerns along with other presentations including headache, pain, tinnitus, audible bruits, palpable thrills, and hemorrhage. Neuro-radiological diagnosis is the cornerstone for the surgical procedure to be performed, and cranial angiography is of great significance for diagnosis and treatment selection. MRA is also of significance for establishing a diagnosis as scalp AVMs are confused with hemangioma and cavernomas. Treatment of the cirsoid aneurysm is difficult due to the abnormal fistulous communications between the feeding arteries and veins and high shunt flow. Management protocols for scalp AVMs include various options including surgical excision, endovascular embolization, ligation, and intralesional injections. Operative blood loss, postoperative cosmetic complications are significant concerns when treating scalp AVMs, thus various methods are used pre and postoperatively in order to control these concerns. A thorough analysis of scalp AVMs regarding anatomy, feeder vessels, size, and other different variables is required for a better understanding of the problem in order to improve the outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Patients with scalp AVMs confirmed by various imaging techniques. AVMs of the scalp will include: cirsoid aneurysm, serpentinum aneurysm, racemosum aneurysm, plexiform angioma, arteriovenous fistula, high flow shunts and arteriovenous malformations.
* Age group: any age group.
* Aetiology: congenital, traumatic, or any.

Exclusion Criteria:

* High risk patients or unfit for surgery.
* Patients refused surgery, or scheduled for endovascular intervention.
Detection of Early Esophageal Squamous Neoplasia

The aim of the present study：

1. To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia.
2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy

Probe-based confocal laser endomicroscopy (pCLE; Cellvizio, Mauna Kea Technologies, Paris, France) is a newly developed endoscopic device and has shown its value for diagnosing Barrett's esophagus, colonal polyps and etc. However, none research has focus on early esophageal squamous neoplasia until now. Previous diagnosis of early esophageal neoplasia is based on the lugol staining which is time wasting and have many adverse events.Other researches have suggested virtual chromoendoscopys are beneficial for screening esophageal tumors. Therefore, the aim of the present study is 1.To investigate the diagnosing value of pCLE for early esophageal squamous neoplasia according to the surface maturation scoring(SMS) diagnostic criteria and 2. To assess the detection rate of early esophageal squamous neoplasia by virtual chromoendoscopy(I-SCAN).

Eligibility Criteria:
Inclusion Criteria:

* Patients aged between 50 and 80 years old
* Patients undergo screening endoscopy or histologically verified esophageal squamous intraepithelial neoplasia before.

Exclusion Criteria:

* Advanced esophageal, gastric or duodenal cancer
* History of upper GI tract surgery
* Coagulopathy or acute GI bleeding
* Pregnant or breast-feeding (for females)
* Impaired renal function
* Allergy to fluorescein sodium
* Inability to provide informed consent.
Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion

Background: Humans naturally produce ketone bodies under daily living conditions. The main ketone bodies are two functioning acids, beta-hydroxybutyric acid (3-OHB) and acetoacetate, and the pH-neutral, but odorous, acetone. In the fed state, level of 3-OHB is suppressed to an almost unmeasurable level while, in the fasted state, it rises to 0.1-0.5 millimoles (mM). Main regulation of ketone synthesis is the abundance of sugars and resulting adaptations in insulin secretion. Thus, ketone bodies are formed when sugar is not readily available and insulin is suppressed. This picture is, to a certain degree, seen in acute inflammatory states and, indeed, during starvation, where level of 3-OHB increases to 5-8 mM.

Hypothesis:

1. Ketone bodies changes the insulin sensitivity and substrate metabolism in human subjects
2. Ketone bodies changes the GH signaling in muscle and adipose tissue

Aim: The investigators wish to provide knowledge on changes in metabolites and shift in signaling pathways and insulin sensitivity during GH infusion and concomitant ketone bodies infusion among healthy subjects.


Eligibility Criteria:
Inclusion Criteria:

* healthy men
* written consent
* body mass index (BMI) 18.5 - 25
* age 20-50 years

Exclusion Criteria:

* any kind of disease
* regular medication
The Acute Effect of Proprioceptive Neuromuscular Facilitation on Cervical Range of Motion, Strength and Proprioception.

the aim of the study was to investigate the immediate influence of proprioceptive neuromuscular facilitation on cervical range of motion, strength and proprioception

the study evaluates the influence of two proprioceptive neuromuscular facilitation techniques (PNF patterns and PNF stretching) on cervical proprioception. PNF techniques are regularly used techniques among physiotherapist. also there is a lack of studies that investigated the effect of PNF on cervical proprioception

Eligibility Criteria:
Inclusion Criteria:

* Neck disability index score of 5 or less
* Able to understand and follow instructions
* Above 18 years old

Exclusion Criteria:

* Cervical trauma
* History of cervical inter-vertebral disc pathology
* Rheumatic diseases
* Whiplash syndrome
* History of surgeries to the neck, face and shoulders
* History of systemic diseases
Improve Oxygenation and Capnographic Detection During Sedative EGD

The purpose of this study is to compare the effect of mandibular advancement bite block and high flow nasal cannula to standard bite block for oxygenation, capnographic measurement, prevention of hypoxemia, intervention events and adverse effects during endoscopic examinations.

During endoscopic examinations, especially during those performed via oral insertion of endoscopes, an oral bite is used to protect the examination instruments and patients. During sedated endoscopic examinations, the patients are under influence of anesthetics. Upper airway obstruction often occurred due to respiratory depression and airway collapse resulting in desaturation. Airway management with high percentage oxygen, jaw thrust, or insertion of nasal airways by trained anesthetic personnel is required during upper airway obstruction emergencies. Nasal airway is invasive and causes nasal bleeding, sinusitis and other problems. Jaw thrust and bag-mask ventilation requires training and is a burden to anesthetic personnel to perform. Oxygenation and capnography are important ventilatory monitors during sedative procedures. These are often influenced by open mouth breathing during upper gastrointestinal endoscopic examinations making oxygenation and capnographic measurements unreliable. In this study, we group the patients into A group using standard of care, B group using mandibular advancement oral bite and C group using high-flow nasal cannulas. After anesthetic induction, gastric endoscopy will be performed. Oxygenation, end-tidal carbon dioxide, and degree of upper airway obstruction will be evaluated and recorded. Differences between the groups will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Male and female patients aged 20 to 80 years with ASA physical status I to II undergoing routine outpatient upper gastrointestinal endoscopy

Exclusion Criteria:

* Baseline oxygen saturation \< 90%
* Known upper airway obstruction, difficult intubation history
* Unstable or lost of upper and lower incisors
* Known past oral or neck surgeries
* Anticipate exam time \> 30 mins
Comparison of Recurrence Between Mini-SLET and Limbal-Conjunctival Autograft Techniques in Primary Pterygium

The surgical treatment options for pterygium, an abnormal growth on the eye's frontal surface can be treated with several surgical techniques. The rates of pterygium coming back varies depending on the surgical technique employed and other factors related to the patient and surgery. The objective of this study is to assess the efficacy and safety of incorporating a single amniotic membrane with stem cells in the treatment of primary pterygium, aiming to enhance surgical outcomes and minimize recurrence rates.

The surgical treatment options for pterygium, an abnormal growth on the eye's surface, encompass various approaches. These include standard surgical excision, which involves removing the pterygium using traditional surgical methods and more recently Simple Limbal Epithelial Transplantation. Recurrence rate of pterygium varies depending on the surgical technique employed and other factors related to the patient and surgery.The objective of this study is to assess the efficacy and safety of incorporating a single amniotic membrane with stem cells in the treatment of primary pterygium, aiming to enhance surgical outcomes and minimize recurrence rates.

Eligibility Criteria:
Inclusion Criteria:

* Patients with primary nasal pterygium \> 2mm
* Patients who can present and continue follow-up for the duration of the study
* Acceptance to participate in the study by signing the informed consent.

Exclusion Criteria:

* Patients with rheumatoid arthritis
* Collagenopathy
* Pregnant
* Infection, conjunctival inflammation or ocular trauma
* Glaucoma
* Previous ocular surgery