cyrilzakka/clinical-trials huggingface dataset:
The Effect of Different Exercises on Lower Extremity Performance in Flexible Flatfoot

In the study, the effects of two different strengthening exercises combined with short foot exercise on lower extremity functional performance and muscle strength will be examined and compared in adults aged 18-45 years with flexible flatfoot. This study was designed as an experimental, 3-arm, parallel group, double-blind randomized controlled study that included a 6-week intervention period.

Participants will be randomly divided into 3 different groups (control group, foot-ankle exercise group, hip exercise group). The control group will be instructed to perform only short foot exercise; the foot-ankle exercise group will be instructed to perform 3-dimensional foot-ankle extension exercise in proprioceptive neuromuscular facilitation (PNF) pattern in addition to short foot exercise; the hip exercise group will be instructed to perform hip abductor and external rotator muscle strengthening exercise (clam exercise) in addition to short foot exercise. Foot-ankle and hip exercises will be performed against resistance with the help of an elastic band, 3 days a week under the supervision of a physiotherapist and progression will be made by changing to a higher level of difficulty band color every 2 weeks. Short foot exercise will be performed every day of the week (3 days under the supervision of a physiotherapist; the rest of the days as a home exercise program) and will be progressed by changing position (sitting, standing, on one leg respectively) every 2 weeks. All exercises will be performed for 6 weeks. Assessments will be performed at the beginning and end of the exercises by another researcher blinded to group allocation. Isometric muscle strength of the intrinsic foot, four-way ankle circumference and hip abductor-external rotator muscles, endurance of the plantar flexors, forward jump and dynamic balance performance will be evaluated respectively.

Eligibility Criteria:
Inclusion Criteria:

* Age range is 18-45 years
* Navicular drop is 10 mm or more
* Getting a value of +6 points or more from the Foot Posture Index-6

Exclusion Criteria:

* Orthopedic and rheumatological diseases of the spinal region and lower extremities
* Surgery history of the spine and lower extremities
* Neurological and systemic disorders
* Describe lower extremity and/or lower back pain in the last 6 months
* Disorders that may affect cognition and balance (otitis media, visual impairment, etc.)
* Body mass index being above normal values (18-24.9 kg/m2)
* Having rigid flat feet and/or hallux rigidus-limitus deformity
* Being involved in regular sports or exercise
* Having received any physiotherapy or rehabilitation treatment for flat feet or hips in the last year
A Study of the Patterns of Use of Etoricoxib in France (MK-0663-148)

This postmarketing study will examine the use of etoricoxib (Arcoxia®) in routine clinical practice in France as well as the use of celecoxib (Celebrex®).


Eligibility Criteria:
Inclusion Criteria:

* Treatment-naive, discontinued the previous treatment course of etoricoxib or celecoxib at least 3 months previously or currently receiving continuous treatment with oral etoricoxib or celecoxib
* Consent to take part in the study
* Included in his/her physician's client base for at least 1 year

Exclusion Criteria:

* Unable to receive follow-up over a year
* Included in an interventional trial
Perioperative Baroreflex Sensitivity

Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension. Perioperative patients with hypertension is rapidly growing in all populations worldwide. However, no study has reported the values of BRS in this cohort. The aim of this study was to estimate the value of BRS for hypertension in a surgery cohort.

Hypertension is known to be a major risk factor of end-organ damage, stroke and coronary mortality.It is estimated that one in six people worldwide, or nearly one billion, are affected by high blood pressure, and it is estimated that this number will increase to 1.5 billion by 2025. The World Health Organization also stated that high blood pressure is the most attributable cause of cardiovascular death.As the speed of aging is accelerated, the amount of perioperative hypertensive patients continue to increase. Perioperative hypertension had been shown to be a risk factor for the development of perioperative morbidity and mortality.Although it has aroused people's attention, there still lack of system evaluation and effective control. Therefore, it's urgent and necessary to assess and intervene perioperative situation of hypertensive patients.

The pathogenesis of hypertension is very complex, while the exact mechanism is still unclear. The dysfunction of autonomic activity, marked in particular by sympathetic overactivity and reduced parasympathetic activity, has been hypothesized to underlie the development of hypertension.Baroreflex control is one of the key mechanisms responsible for the short-term control of blood pressure.It acts as a closed loop, negative feedback mechanism, aimed at stabilizing blood pressure around a set point value.The impairment of baroreflex sensitivity (BRS) is know as the predictive factor of mortality in hypertension. A large of clinical and basic research indicated the existence of autonomic dysfunction and impaired BRS in patients with essential hypertension.

However, no study has reported the values of perioperative BRS, especially in hypertensive patients . Therefore, the aim of this study was to estimate the value of BRS for hypertension in a surgery cohort, and to explore the functional status of autonomic nervous system, may provide reference for clinical treatment.

Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing ordinary thoracic surgery and age between 18 and 70;
2. American society of anesthesiologists(ASA) classification I to II level;
3. Willing to participate in this study and signed an informed consent

Exclusion Criteria:

1.Patients with diabetes mellitus, cardiopulmonary dysfunction, severe liver and kidney dysfunction and disease of nervous system;
The Effect of Biscuit Containing Kothala Himbutu on Blood Glucose in Patients With Diabetes. A Randomized Control Study

The investigators intend to conduct a triple blind randomized clinical trial to investigate the effect of a biscuit containing herbal extract, available in the market on the fasting blood sugar control in patients with diabetes mellitus and also to find out whether there are any side effects on other vital organs such as kidneys and liver.

The effect of a biscuit containing the extract of Salacia reticulata (Kothala Himbutu) on the reduction of blood glucose levels in patients with Type 2 Diabetes Mellitus. A single center randomized triple blind placebo controlled two period two sequence crossover clinical trial.

Eligibility Criteria:
Inclusion Criteria:

1. Type 2 diabetes for minimum period of 6 months
2. Aged between 30 and 65 years
3. Stable glycaemic control over the preceding 2-3 months. They will be initially selected from a range of HBA1C varying from 6.5 - 14 and the individual subject should not have a variation of \>20% between the previous HBA1C and the HBA1C done at the commencement of the study

Exclusion Criteria:

1. Chronic kidney disease with estimated Glomerular filtration rate less than 30ml/hour
2. Severe valvular heart disease or heart failure.
3. Those on Insulin therapy
4. Severe liver disease (AST \> 10 X times the upper limit)
Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers

We have an active research program in gastrointestinal cancers including clinical trials, epidemiologic, and translational studies. We would like to establish a biospecimen bank linked to useful clinical information in order to learn more about diagnostic, predictive and prognostic markers for gastrointestinal cancers.

PRIMARY OBJECTIVES:

1. To collect and store tumor and normal tissue (previously collected paraffin embedded or frozen specimen) and blood in patients with gastrointestinal (GI) cancers.

SECONDARY OBJECTIVES:

1. Collect detailed clinical information via a patient questionnaire that includes demographic, socioeconomic, lifestyle, family, past medical, medication and cancer histories
2. Collect details about the tumor specimen extracted from patient charts.


Eligibility Criteria:
Inclusion Criteria:1. Patients are eligible if they have a histologically proven gastrointestinal cancer (esophageal, gastroesophageal junction, gastric, small intestine, appendix, colon, rectum, anus, liver, gallbladder, bile ducts, pancreas, neuroendocrine, and GI stromal tumor).

2. 18 years of age or older

3. Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria:None
Magnetic Resonance Elastography (MRE) of Uterine Fibroids

The purpose of this study is to gain additional information regarding use of Magnetic Resonance Elastography (MRE) for uterine fibroid characterization. In this study, the investigators will use a new noninvasive technology, MRE, to further characterize the elastic properties of the uterine fibroids. To date, very little is known concerning how the tissue composition of the uterine fibroid may affect its treatment with Magnetic Resonance Guided Focused Ultrasound (MRgFUS).

In this study, the investigators will use a new noninvasive technology, magnetic resonance elastography (MRE), to further characterize the elastic properties of the uterine fibroids. This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids. It is known that some fibroids with increased T2-signal on Magnetic Resonance Imaging(MRI) can be more difficult to treat.

This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids.

This is a single-site, non-randomized pilot study to determine whether Magnetic Resonance Elastography (MRE) can be optimized for clinical use as part of the patients routine clinical imaging and to correlate with MR signal characteristics of the uterine fibroid.

MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging protocol.

Aims:

Specific Aim 1: To acquire magnetic resonance elastography images on women who have a clinically ordered pelvic magnetic resonance imaging (MRI) for uterine fibroids.

Specific Aim 2: To examine the correlation between MRE stiffness values and MR T2 signal characteristics for uterine fibroids. For a subset of patients going on to surgery correlation with pathology can also be performed.

This study will seek to determine whether MRE can be performed in the pelvis on a routine clinical basis as well as correlating the MRE findings with magnetic resonance signal characteristics. There are no additional risks to the patient and no additional cost to the MRI exam.

Eligibility Criteria:
Inclusion Criteria:

1. Women able to give informed consent
2. Women having uterine imaging

Exclusion Criteria:

1. Women currently pregnant
2. Allergy to either gadolinium or iodinated contrast
3. Severe claustrophobia
4. Weight in excess of 250 pounds
A PK Study to Evaluate PUR0200 and a Reference Product in Healthy Subjects

The purpose of this study is to compare drug blood levels of multiple formulations of inhaled PUR0200 to each other and to the reference product with and without oral charcoal.

The purpose of this study is to compare 5 different formulations of PUR0200 to the reference product. All formulations will be inhaled. In 6 of the 7 study periods either PUR0200 or the reference product will be inhaled under fasting conditions without oral charcoal. In the 7th study period, half of the subjects will receive reference with oral charcoal and the other half will receive reference product without oral charcoal.

Eligibility Criteria:
Inclusion Criteria:

* Healthy male or female subject
* Age between 18 and 50 (inclusive) years
* Non-smokers or ex-smokers (stopped at least 6 months ago)
* FEV1 ≥80% of the predicted value
* Completion of 3 training inhalations

Exclusion Criteria:

* Pregnant and/or nursing women. Positive pregnancy test at entry visit or on hospitalization day 0 of each study period.
* fertile women without reliable contraception
* participation in ANY research study within 3 months prior to entry visit, or simultaneous participation in another clinical study
* blood donation or blood loss within last 3 months
* treatment with ANY investigational study drug (i.e. drug not yet approved) in the last 3 months before entry visit
* intake or administration of any prescribed systemic or topical medication including over the counter (OTC) medication or natural food supplements (e.g. vitamins, garlic, or ginger capsules) within 2 weeks before entry visit
* current or history of drug abuse within 5 years before entry visit
* alcohol abuse
* regular consumption of beverages or food containing methylxanthines (i.e. coffee, tea, cola, caffeine containing sodas, chocolate) equivalent to more than 500 mg methylxanthines\* per day
* presence or a history of clinically significant cardiovascular, renal, hepatic, pulmonary, metabolic, endocrine, hematological, gastrointestinal, neurological, psychiatric or other diseases
* major surgery of the gastrointestinal tract except for appendectomy, or any pulmonary surgery
* clinically significant illness (including upper or lower respiratory infection and/or candidiasis of the mouth and throat) within 4 weeks before entry visit
* any acute or chronic disease which might interfere with inhalation, absorption, distribution, metabolism or excretion of the drug special diet due to any reason, e.g. vegetarians
* positive serologic findings for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (HBsAg), and/or hepatitis C virus (HCV) antibodies
* excessive physical activity (more than 4 times per week for more than 90 minutes) within the last 6 months and during the study
Investigation the Effects of Stabilization Exercises on Pain, Disability and Activity of Pelvic Floor Muscles in Patients With Postpartum Lumbopelvic Pain

The purpose of this study was to evaluate the effects of stabilization exercises on pain, disability and pelvic floor muscles function in patients with lumbopelvic pain.

Pregnancy is a specific experience that leads to several physical changes in women's body and influence most aspects of their lives. Pregnancy and delivery can cause serious complications such as urinary incontinence, pelvic organ prolapse, fecal incontinence, and low back pain (LBP) that have negative effects on women's sexual, physical, social and psychological health.

Based on Wu et al. systematic review, prevalence of pregnancy related low back pain (PLBP) during pregnancy and postpartum is 45% and 25% respectively.

LBP is one of the most current causes of disability and sick leave after delivery.Abnormal load transfer in the lumbopelvic region has been considered as one possible explanation to lumbopelvic pain.The local stabilizing muscles, i.e. the transversely oriented abdominal, diaphragm, the lumbar MF and the PFM Play an important role in load transfer in the lumbopelvic region.so, we considered that an exercise program that addresses muscular dysfunction, such as lumbar stabilization exercise can improve motor pattern of local stabilizing muscles and can use in management of postpartum lumbopelvic pain.

Eligibility Criteria:
Inclusion Criteria:

* age more than 18 years old
* pain located between costal margin to gluteal fold with or without radiation to lower limbs
* onset of pain during pregnancy or after delivery
* history of delivery at least 3 months ago.

Exclusion Criteria:

* known chronic rheumatologic or Orthopedic disorders
* systemic locomotor disease
* history of fracture, neoplasm,intervertebral disk pathology or radiculopathy, spondylolysis or spondylolysthesis
* contraindication of exercises, heart disease, diabetes, thrombophlebitis, uncontrolled epilepsy
* ongoing pregnancy
* treatment with specific stabilisation exercise during previous 3 months.
Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible Pulpitis

This study aims to evaluate the comparative efficacy of two different local anaesthetic agents for supplemental buccal infiltration after a failed inferior alveolar nerve block in achieving profound pulpal anaesthesia for symptomatic irreversible pulpitis using 2% lignocaine and 4% articaine with vasoconstrictor epinephrine.

Alternate hypothesis:

There is a mean difference in local anaesthesia effectiveness of 2% lignocaine and 4% articaine containing epinephrine when used for buccal infiltration in pulpectomy of symptomatic irreversible pulpitis of mandibular posterior teeth after a failed inferior alveolar nerve block

Patients diagnosed with symptomatic irreversible pulpitis are included in this study. Teeth will be divided into two groups after a failed inferior alveolar nerve block using 2% lignocaine containing 1:100,000 epinephrine. A sample size of 123, with the first group consisting of 62 patients, 2 cartridges of 32mg of 2% lignocaine with 1:100,000 epinephrine will be used for supplemental buccal infiltration. In group 2 of 61 patients, 40mg of 4% articaine with 1:100,000 epinephrine will be used. During the root canal treatment, a subjective assessment of lip anesthesia is recorded. An electric pulp tester is used for the evaluation of the presence or absence of pulpal anesthesia. A verbal analogue scale is also used to evaluate the presence or absence of pain.

After taking a brief history, informed consent will be taken. A rubber dam will be used. Electric pulp tester will be used on the control contralateral tooth, the experimental tooth preoperatively; after giving nerve block and achieving Lip numbness, the experimental tooth will again be evaluated with Electric pulp tester. An access cavity will be made. If there is still no pulpal anesthesia, supplemental anesthesia will be administered and Electric pulp tester will be used again.

A questionnaire containing a numerical rating scale will be given to each patient to record the intensity of pain felt after giving supplemental anesthesia.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with ages ranging from 18-to 55 years
2. Male/ Female
3. Mandibular posterior teeth with symptomatic irreversible pulpitis
4. Ability to understand the use of the pain scale
5. Patients with adequate oral hygiene and willing to participate in the study

Exclusion Criteria:

1. Any type of medication consumed before treatment
2. Patients who do not show profound lip numbness after giving inferior alveolar block
3. Periapical pathologies ( periapical abscess, sinus tract, periapical cyst, pulpal necrosis)
4. External resorption
5. Unfavorable location of the tooth, internal ankylosis, trismus, severe tooth malposition.
Patient Portal Use by Parents of Spanish-Speaking Children

The purpose of this study is to determine whether patient portal access is feasible and useful for Spanish-speaking parents.

Participants will be given an electronic tablet and will be taught how to access their child's medical record and other electronic health resources using the tablet.


Eligibility Criteria:
Inclusion Criteria:

* Be parent/legal guardians of children receiving care in UNC's Children's Clinics
* Have Spanish as preferred language of individual identifying as primary caregiver
* Have never activated MyChart (patient portal)
* Have internet service at home OR ability to easily access internet service
* Have at least one child under age 13

Exclusion Criteria:

* Medically unstable at time of recruitment
The Effect of Attention on Postural Control

Objective: This study investigates the relationship between postural control and sustained attention in individuals with probable ADHD. Motor control issues, including balance deficits, are observed in 30-50% of children with ADHD. These deficits may extend into adulthood, yet research on postural control in adults with ADHD is limited. This study aims to address this gap by exploring the connection between attention and postural stability in adults with ADHD.

Background: ADHD is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity, affecting both children and adults. Studies have shown that postural control relies on coordinated functioning of sensory and neuromotor systems, which ADHD may impact. In children, postural challenges are more pronounced in conditions requiring complex sensory integration. However, research on adults with ADHD is sparse, though preliminary findings suggest postural instability and possible links to cerebellar differences.

Methodology: The study evaluates sustained attention and postural control in adults with ADHD, using the Adult ADHD Screening Scale (ASRS-5) and postural stability assessments under dual-task conditions. By examining attention-driven postural responses, the study contributes to developing therapeutic balance protocols for individuals with ADHD.

Hypotheses:

H0: No relationship exists between postural control and sustained attention in individuals with ADHD.

H1: A relationship exists between postural control and sustained attention in individuals with ADHD.

Significance: This study contributes to a better understanding of the neurophysiological links


Eligibility Criteria:
Inclusion Criteria:

* Volunteers between 18-30-year-olds
* Not having any problems with balance

Exclusion Criteria:

* Having a physical injury in the last 6 months (such as ankle sprain)
* Having any neurological disorder
* Exercising regularly for the last 12 months
Mesalamine Granules for Irritable Bowel Syndrome (IBS) With Diarrhea

The purpose of this study is to determine the daily dose of mesalamine granules that will provide adequate relief from symptoms of IBS with diarrhea.


Eligibility Criteria:
Inclusion Criteria:

Male or non-pregnant, non-lactating female subjects Diagnosed with IBS confirmed by the Rome III criteria

Meet the following IBS symptom scores in all categories during the diary eligibility period:

* An average daily score of greater than or equal to 3 for abdominal pain
* An average daily score of greater than or equal to 3 for bloating
* An average daily score of 5 or greater for stool consistency using the Bristol Stool Scale
* Does not have adequate relief of IBS symptoms (weekly reported) over the past 7 days on the first day of screening and on the day of randomization

Exclusion Criteria:

* Present with hard or lumpy stools (Type 1 or Type 2) on the Bristol Stool form Scale during the diary eligibility period
* history of inflammatory bowel disease
* has Type 1 or 2 diabetes
* pregnant or lactating
* history of HIV or hepatitis B or C
Iatrogenic Withdrawal Symptoms in Severe Traumatic Brain Injury

Iatrogenic withdrawal symptomes has been associated with prolonged mechanical ventilation and the and the derived symptoms such as fever and agitation has been shown to cause significantly prolonged ICU and hospital length of stay. The incidence of IWS in the adult general ICU ranges from 16,7-55%. To this date, the incidence of IWS has not been studied in patients with TBI.


Eligibility Criteria:
Inclusion Criteria:

* adult patients suffering from severe TBI and were mechanical ventilated and received continuous infusions of opioids, benzodiazepines and neuromuscular blocking agents for 72ours or more

Exclusion Criteria:

* age \<18 years, patients who died before discharge, chronic alcohol abuse, regular use of heroin, cocaine and amphetamines, chronic use of opioids, patient that were primary admitted to other ICUs and patients that were moved to other ICUs with ongoing infusions.