cyrilzakka/clinical-trials huggingface dataset:
Immediate Impact of Lumbar Fascia Stretching on Hamstring Flexibility

Introduction: the hamstring muscles has a great tendency to decrease its extensibility, originating a pathology with a own clinical entity, the Short Hamstring Syndrome (SHS), in addition to other problems on adjacent structures. All this present a great socioeconomic impact in the investigator's society. Various techniques have been demostrated to prduce an increase in flexibility, among which are the fascial techniques.

Objective: to evaluate the immediate efficacy of the treatment of the lumbar fascia in the flexibility of the hamstring musculature.

Methods: 41 women between 18 and 39 years old, in two groups. The experimental group received a technique of fascial stretching in the lumbar area while the control group participated in an off magnetotherapy machine. The hamstring flexibility in both lower limbs was measured by the Straight Leg Raising Test (SLR) and the Passive Popliteal Angle Test (PKE).

The hamstring muscles has a great tendency to decrease its extensibility, originating a pathology with a own clinical entity, the Short Hamstring Syndrome (SHS), in addition to other problems on adjacent structures. This study aims to help improve treatment for the problem mentioned before, which can be included within a therapeutic framework to combat SHS. In recent years, investigations have been carried out that include different techniques for stretching the hamstring muscles, as well as the treatment of other structures belonging to the posterior superficial chain. Within this last section, myofascial stretching techniques have been shown to be effective both in the short and medium term. Different techniques for stretching the hamstring muscles have been carried out with the aim of increasing the flexibility of the lower back in general.

he objective is to evaluate the immediate efficacy of the treatment of the lumbar fascia in the flexibility of the hamstring musculature.

The participants are 41 women between 18 and 39 years old, in two groups. The experimental group received a technique of fascial stretching in the lumbar area while the control group participated in an off magnetotherapy machine. The hamstring flexibility in both lower limbs was measured by the Straight Leg Raising Test (SLR) and the Passive Popliteal Angle Test (PKE).

Eligibility Criteria:
Inclusion Criteria:

* Female between 18 and 39 years old.
* Signed informed consent

Exclusion Criteria:

* Any alteration that prevents the normal communication between the patient and the therapist at the time of the study.
* Have an injury in the hamstring muscles.
* Have a chronic or acute lumbar pain in the moment of the realization.
* Neurological or orthopedic desease.
* Any important estructural alteration in the lower members that may be likely to alter the results under study.
A Pilot Test of the Relaxation Response Resiliency Program (3RP) in Spanish Speaking World Trade Center Survivors With Post Traumatic Stress Disorder (PTSD)

The objective of this protocol is to test the feasibility and acceptability of the Relaxation Response Resiliency Program (3RP), a psychotherapy treatment providing a variety of mind body skills and interventions to decrease medical and mental health symptoms and build resilience, in Spanish-speaking World Trade Center (WTC) survivors, and to examine its clinical effectiveness to reduce Post Traumatic Stress Disorder (PTSD), depression, anxiety, and lower respiratory symptoms (LRS) and improve psychosocial functioning.


Eligibility Criteria:
Inclusion Criteria:

* score \> or = 44 on the PTSD Checklist PCL, considered the broad definition of PTSD syndrome71
* report at least one LRS symptoms (i.e., shortness of breath, wheezing, dyspnea or cough).
* Spanish Speaking

Exclusion Criteria:

* regular practice of eliciting relaxation response (i.e., meditation, yoga) in the past 6 months,
* serious unmanaged mental illness including bipolar disorder, psychosis, and active substance misuse disorders;
* inability to participate in consecutive sessions over 3-month period.
Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults

Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor associated with long-term mortality among different patient populations. Renal dysfunction and subsequent chronic kidney disease is implicated in the development of hypertension and cardiovascular disease. The investigators overall hypothesis is that, in the pediatric population, sepsis-related AKI will have unrecognized, long-term consequences with regard to kidney function, endothelial function, blood pressure control, and overall health.

This will be a two-arm cross-sectional control-cohort outpatient evaluation. Subjects with sAKI and a random selection of non-sAKI subjects who agree to participate in another study of quality of life survey will be asked to participate in the outpatient study. Subjects will be asked to come in to the Clinical Research Center for 24-hour monitoring and participate in the outpatient study where urinary and serum studies to measure glomerular filtration rate, renal plasma flow followed by blood pressure monitoring, peripheral arterial and applanation tonometry.

Eligibility Criteria:
Inclusion Criteria:

For all patients:

• Age 18-24 at time of participation in the study

For non-AKI sepsis patients:

* Hospitalization with a diagnosis of sepsis from 1998-2014
* Failure to meet pEDRIFLE criteria for AKI during incident sepsis admission
* Participation in cognitive survey study with completion of the PedsQL survey

For sAKI patients:

* Hospitalization with a diagnosis of sepsis from 1998-2014
* Severe AKI as defined by the pEDRIFLE criteria during incident sepsis admission
* Participation in cognitive survey study with completion of the PedsQL survey

Exclusion Criteria:

For all patients:

* Known pre-existing CKD as defined by history of kidney transplant or long-term dialysis
* Age greater than 18 years at the time of incident sepsis admission
* AKI from primary kidney disease including acute glomerulonephritis and obstructive uropathy
* Pregnancy at the time of enrollment
* Known or suspected allergy to gadolinium based contrast
* Known or suspected allergy to iodine or shellfish will be excluded from RPF measurement with iodohippurate
* Heart failure or condition whereby the administration of 0.9% normal saline would be contraindicated
Effects of Different Oxygen Concentrations on Lung Ultrasound Score During Spontaneous Ventilation

The goal of this study is to observe the effects of different oxygen concentrations during preoxygenation in spontaneous breathing patients with modified lung ultrasound scores before induction of general anesthesia. Preoxygenation is a routine and recommended procedure for patients undergoing general anesthesia. Atelectasis is a common side effect of general anesthesia and usage of high concentration oxygen is a probable cause of it. Using lower oxygen concentrations in preoxygenation may help reducing the atelectasis and it can be assessed by lung ultrasound.

Preoxygenation is the process of supplying the patient a high inspired fraction of oxygen prior to an airway intervention or induction of general anesthesia. Prolonging safe apnea duration is the primary aim of preoxygenation and preoxygenation is recommended for all patients before induction of general anesthesia.

Atelectasis is the most common postoperative pulmonary complication and is associated with usage of high inspired fraction of oxygen. Modified lung ultrasound scoring is an effective and noninvasive method to determine atelectasis. In this study we will observe the effects of different oxygen concentrations during preoxygenation before induction of general anesthesia in spontaneous breathing patients with modified lung ultrasound scores .

Patients undergoing general anesthesia for elective surgery meeting the criteria will be acknowledged about the study. After written consents are taken patients will be randomised into two groups by coin method. One group will receive %80 oxygen for 3 minutes and other group will receive %100 oxygen for 3 minutes during preoxygenation. Each participants demographic data will be collected. 12 quadrants of thorax divided by midsternal line, anterior axillary and posterior axillary lines will be examined by the usage of modified lung ultrasound score before and at the end of preoxygenation for all individuals. Randomisation, lung ultrasound scoring and preoxygenation will be done by different experienced anesthesiologists so the observers of this study would be blinded for the results. Patients will be blinded for the concentration of oxygen. Modified lung scores of each group would be compared at the end of the study.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists Score I and II
* Being a candidate to elective surgery under general anesthesia

Exclusion Criteria:

* Patients with any pulmonary disease
* Patients who had pulmonary infection in the past 3 months
* Patients who had a surgery in the past 3 months
* Patients who had a multitrauma in the past 3 months
* Patients who have a Body Mass Index over 30
* Pregnants
* Patients who have diaphragma hernia
* Patients who have gastroesophageal reflux disease
ADOPT-PRESTAGE: Study Evaluating the Impact of the Program PRESTAGE

As the proportion of oral anticancer treatments is continuously increasing, adherence appears as a major issue for patients' outcomes. Poor adherence affects particularly geriatric patients due among others to polypharmacy or cognitive impairment. Thus, the need for educational programs in this population has been regularly emphasized.

PRESTAGE educational program was built after an external and internal analysis of educational needs in elderly patients treated with oral cancer treatments. It implicates a multidisciplinary educational team (nurses, physicians, pharmacists, psychologists, physiologists, social workers...). Six educational workshops were designed with the following endpoints: disease and treatment understanding, treatment management, nutrition and psychological as well as physical well being.

ADOPT-PRESTAGE is a clinical, prospective, interventional, open-label, multicenter, randomized, controlled trial designed to evaluate the impact of PRESTAGE program. It is, to the investigators' knowledge, the first randomized controlled trial evaluating the acceptability and impact (adherence, clinical benefit) of an educational program in an elderly cancer population. The primary endpoint of this trial will be to evaluate adherence using an indirect objective adherence measure: the Medication Event Monitoring System (MEMS). Secondary endpoints include quality of life and evaluation of changes in patients' behaviors.


Eligibility Criteria:
Inclusion Criteria:

* Patients older than 70 years,
* For which oral anticancer therapy has been initiated within the previous 45 days or will be started within 45 days
* For any type of cancer, solid or hematologic, any stage
* Estimated life expectancy\> 6 months
* Affiliation to social security or equivalent
* Patients who can answer questionnaires and protocol evaluations
* Informed consent signed by patients
* Domiciled within 50 km around the investigating center

Exclusion Criteria:

* For patients with breast cancer, exclusive treatment with hormone therapy
* First-generation Hormone Therapy in Prostate Cancer
* Patient not available for regular follow-up whatever the cause (geographic, family, social, psychological)
* Any serious condition, ie serious physical or mental, leading to a disability permanent and likely to prevent the proper course of treatment
* Patient deprived of liberty or under guardianship
Renal Safety of Bowel Preparation With Polyethylene Glycol

This study evaluates the changes of renal function after taking bowel cleansing agent polyethylene glycol for elective colonoscopy.

Polyethylene glycol (PEG) is the most commonly used bowel cleansing agent for colonoscopy in the world.

PEGs are non-absorbable isosmotic solutions that pass through the bowel without net absorption or secretion. Significant fluid and electrolyte shifts are therefore attenuated.

However, several studies have shown that PEG may also impair renal function. One recent population-based study reported that the use of PEG was associated with an increased risk of acute kidney injury.

The renal safety of PEG in Taiwanese patient has not been reported.

Eligibility Criteria:
Inclusion Criteria:

* Subjects 40 yrs of age or older scheduled for elective colonoscopy.

Exclusion Criteria:

* Severely reduced kidney function (eGFR\] \<30 mL/min/1.73 m2)
* Serum electrolyte abnormalities at screening
* Uncontrolled congestive heart failure (American Heart Association Classification III or IV)
* Unstable angina
* Untreated dysrhythmia
* Myocardial infarction, percutaneous transluminal coronary angioplasty, or coronary artery bypass graft surgery within the previous 3 months
* Ascites
* Current acute exacerbation of chronic inflammatory bowel disease
* Toxic colitis or toxic megacolon
* Ileus and/or acute obstruction or perforation
* Ileostomy
* Right or transverse colostomy
* Subtotal colectomy with ileosigmoidostomy

  * 50% of colon removed
* Idiopathic pseudo-obstruction
* History of gastric stapling or bypass procedure
* Difficulties swallowing
* Treatment with an investigational drug or product
* Participation in a drug study within 30 days prior to receiving study medication
* Treatment with another bowel preparation within 21 days prior to colonoscopy
* Known allergy or hypersensitivity to PEG solution
Post-operative Sore Throat as Determined by Endotracheal Tube Inflation Technique

The purpose of this study is to test whether the incidence of sore throat and other tracheal co-morbidities such as dysphagia and hoarseness can be lessened by use of a cuff manometer at the beginning of surgery to inflate to the proper pressure compared to the standard technique.

The investigators hypothesis is that inflation of the endotracheal balloon using a cuff manometer immediately after intubation will reduce the incidence of sore throat and other tracheal co-morbidities.


Eligibility Criteria:
Inclusion Criteria:

* Scheduled for general anesthesia requiring endotracheal intubation with planned duration of at least 2 hours
* ASA I-3

Exclusion Criteria:

* Planned prolonged intubation
* Planned postoperative ICU admission
* Non English speaking
* Mentally impaired
* Existing tracheal stoma
* Nasogastric tube in place preoperative
* Thyroid / intra-oral surgery
* Previous general anesthesia within the last 2 weeks
* Use of steroids within one week before surgery (IV,inhaled, oral)
Impact of Obesity on Clinical Outcomes in Patients Receiving Acyclovir for HSV Encephalitis"

Multicenter retrospective chart review of patients admitted to any of the six study centers (SSM Health - St. Clare, St. Mary's, Saint Louis University Hospital, St. Anthony's, St. Mary's Madison, Rush University Medical Center, or Methodist Dallas Medical Center) between January 1, 2013 and December 31, 2019 will be conducted. All study centers utilize Epic ® electronic health record (Verona, Wisconsin; www.epic.com) for which all data will be extracted from. Each study center will obtain individual IRB approval prior to data collection. SSM - St. Clare will serve as the lead center for the study with all other centers sending collected and de-identified data to this central site for analysis.

* Obese - WHO definition: Body Mass Index \> 30 kg/m2
* Ideal Body Weight (IBW) (male) - 50.0 kg + 2.3 kg x (patient height in inches, above 60 inches)
* Ideal Body Weight (female) - 45.5 kg + 2.3 kg x (patient height inches, above 60 inches)
* Adjusted Body Weight - IBW + \[0.4 x (ABW - IBW)\]
* HSV encephalitis - PCR positive for HSV-1 or HSV-2 in CSF during index admission
* Baseline Serum Creatinine (S Cr) - The SCr value obtained before the start of acyclovir therapy on which the dose of acyclovir should be based upon
* Acute Kidney Injury (AKI) - per RIFLE criteria and while receiving acyclovir: SCr doubles or urine output \< 0.5 mL/kg/hour for 12 hours
* End-stage renal disease (ESRD) on admission - mention of a diagnosis of ESRD in electronic medical records prior to receipt of acyclovir
* Guideline-approved, weight-based doses - within 10% of 10 mg/kg dose (to account for rounding due to vial size)
* Adequate hydration - IV fluid order (other than KVO \[keep vein open\]) within 24 hours before acyclovir start AND either IV fluid order (other than KVO) for majority of acyclovir course or IV fluid + oral diet for majority of acyclovir course
* Appropriately renally dose-adjusted doses - Frequency of acyclovir matches package insert recommendations based on creatinine clearance at baseline
* Interacting medications - Mycophenolate, probenecid, zidovudine, tenofovir, valproic acid, phenytoin

Eligibility Criteria:
Inclusion Criteria:

* Patients Admitted to a SSM Health - St. Clare (STL), St. Mary's (STL), Saint Louis University Hospital (STL), St. Anthony's (OKC), St. Mary's Madison (WIS), Rush University Medical Center (RUMC), or Methodist Dallas Medical Center
* \> 18 years old
* Positive cerebrospinal fluid (CSF) PCR for HSV-1 or HSV-2
* BMI \> 30 kg/m2
* Received guideline-approved, weight-based doses of IV acyclovir for HSV encephalitis for at least 72 hours during the index admission
* Received appropriately renal dose-adjusted doses of IV acyclovir per package insert recommendations

Exclusion Criteria:

* More than one dosing weight strategy utilized for \> 24 hours for IV acyclovir dosing during the index admission
* Patients transferred to the hospital already on IV acyclovir for HSV encephalitis
* ESRD on admission
* Concomitant pathogen causing meningitis or encephalitis
* Oral acyclovir used for treatment
PleuraSeal Pivotal Study (US)

To evaluate the safety and effectiveness of Confluent Surgical's PleuraSeal Sealant System in the treatment and control of intra and postoperative air leaks following pulmonary resection via an open thoracotomy. The performance of the PleuraSeal Sealant System as an adjunct to conventional closure techniques (i.e. surgical staples or sutures) will be compared to conventional surgical techniques alone.


Eligibility Criteria:
Inclusion Criteria:

* Elective pulmonary lobectomy, segmental and/or wedge resection in one or more lobes via an open thoracotomy
SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism?

Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise.

The main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent
* Caucasian
* Postmenopausal women
* Aged 45-70 years at start of the study
* Body mass index (BMI) 25 - 35 kg/m2
* Stable dietary habits (no weight loss or gain \>5kg in the past 3 months)
* Sedentary lifestyle (not more than 2,5 hours of exercise per week in the past 3 months)

Exclusion Criteria:

* Not able to complete the sitless try-out day according to the protocol
* Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
* No use of medication interfering with investigated study parameters (as determined by responsible physician)
* Alcohol consumption of \>2 servings per day
* Smoking in the past 6 months
* Participation in another biomedical trial which may have an effect on insulin sensitivity less than one month before the start of the study (screening visit)
* Mental or physical disability which interferes with physical activity
* Subjects with contra-indications for magnetic resonance imaging (MRI)
* Reported participation in night shift work 2 weeks prior to the start of the study (screening visit) and during study participation. Night work is defined as working between midnight and 6.00 AM.
Intra-articular Viscosupplement Application in Knee Osteoarthritis

Knee osteoarthritis (OA) is one of the common diseases which causes pain and disability with increasing age. In developed countries, it is said to be one of the ten diseases which decreases functionality most.

Knee osteoarthritis (OA) is one of the common diseases which causes pain and disability with increasing age. In developed countries, it is said to be one of the ten diseases which decreases functionality most. With a prevalence between 22% - 39%, 7% of which are patients who are over 65 years old, and when examined world-wide, it is stated that knee OA is seen 18% of women and 9,6% of men. Knee OA is characterized by pain, and; functional loss and progressive mobility where motions are required a physical activity of lower extremity. The disease causes 80% of restriction of motions and 25% of restriction of daily life activities. Additionally, along with the loss of proprioception, it can be seen defects of static and dynamic postural stability and the loss of balance. The factors of disease cause reduced muscle strength, defects of functionality of muscles and reduced workout capacity. According to the radiographic classification of Kellgren and Lawrence, quadriceps muscle weakness is frequently seen without atrophy and pain in early phases of knee OA of which degree is 0 or 1. If the symptoms are accompanied by a knee pain, the weakness of muscles will show an increase more and cause dysfunction and progression of disease. An increase of force in the muscles of quadriceps and hamstring plays a positive role for stability and mobility of joints and pain tolerance.

In the literature, studies with intra-articular HA injection in the treatment of knee OA are frequently seen, but the number of studies about the co-injection of HA, CS and GA is scarcely any. At the same time, studies investigating the effect of intra-articular viscosupplementation injection on isokinetic muscle strength was not observed. Therefore, the investigators aimed at investigating the effects of HA, CS and GA injection on isokinetic quadriceps and hamstring muscle strengths in our study.

Eligibility Criteria:
Inclusion Criteria:

* being between 40-65 years of age,
* being diagnosed with Stage 3 and 4 knee OA according to the Kellgren-Lawrence classification

Exclusion Criteria:

* any lower extremity deformity (knee flexion contracture, knee hyperextension, varus and valgus deformities),
* septic arthritis, rheumatoid arthritis,
* major dysplasia,
* congenital anomalies, acromegaly, primary osteochondromatosis,
* Ehler-Danlos syndrome,
* neuropathic arthropathy,
* hyperparathyroidism, hypothyroidism,
* diabetes mellitus,
* active synovitis,
* severe knee traumas,
* previous surgery and in the last year,
* knee arthroscopy, injections and fracture history and pregnancy