cyrilzakka/clinical-trials huggingface dataset:
Development of Tumor Organoids from Undifferentiated Primary Carcinomas to Guide Therapeutic Decisions

The study is based on the constitution of a collection of tumor and blood samples for the development of tumoroid for functional tests to predict clinical response to treatment.


Eligibility Criteria:
Inclusion Criteria:

* Patient with undifferentiated primary carcinoma (UPC) with histological and immunohistochemical evidence, validated in a local and/or national UPC multidisciplinary consultation
* Patient with indication for 1st-line treatment at the time of inclusion.
* Patient with life expectancy greater than 3 months
* Patient of legal age
* Patient affiliated to a social security scheme
* Signature of informed consent prior to any specific study procedure

Exclusion Criteria:

* Persons deprived of their liberty or under guardianship (including curatorship)
* Pregnant or breast-feeding patient
Effect of Palm Olein Intake on Lipid Profile and Appetite Regulation

Aims: To investigate whether acute ingestions of palm oil will have an effect on appetite regulation

Design: A randomized, single blind, cross over design including 4 single study visits separated by a week. Visit 1 is an acclimatization visit followed by visit 2,3, and 4 where different types of fat will be given.

Population: 12 healthy males and females aged between 18 and 60 years with body mass index (BMI) between 18.5- 29.9kg/m2 and normal fasting plasma glucose and no evidence of insulin resistance will be recruited. No-pre existing morbidity including cardiac, hepatic or renal disease, history of diabetes, hypertension or hyperlipidaemia.

Treatment: Acclimatization visit: At visit 1, all participants will be given a milkshake like drink containing fat, protein and carbohydrate. A cannula will be inserted for the duration of the study day but no blood will be taken. Studies show than during the first visit stress response can affect the metabolic response to the study drink resulting in inaccurate results.

Study visit 2,3,4: following the acclimatization visit, participants will attend 3 more study visits separated by a week to test the metabolic response to the following fats: palm olein, interesterified palm olein and soybean oil in random order. Participants will be asked to complete a visual analogue scale questionnaire about their appetite at each time point. Fasting and postprandial plasma glucose, insulin, appetite hormones and lipids will be measured.


Eligibility Criteria:
Inclusion Criteria:

* Healthy and overweight male and female volunteers of all ethnicities (body mass index (BMI) of 18.5-29.9 kg/m2)
* Age between 18-60 years (inclusive)

Exclusion Criteria:

* Abnormal liver function test (elevated alanine aminotransferase and aspartate transaminase)/ abnormal kidney function test (elevated plasma creatinine)
* History of type 2 diabetes mellitus, cancer, stomach ulcers, drug abuse or alcoholism, gastrointestinal disorders like Crohn's disease
* Smokers
* On lipid/blood pressure- lowering medication/supplements
* Blood pressure\>140/90 mm Hg
* Fasting total cholesterol \> 6.2 mmol/L
* Fasting triacylglyceride \> 2.0 mmol/L
* Subject must not be allergic to intervention
* Pregnancy and breastfeeding (pregnancy test will be undertaken at the screening visit)
* Subjects taking nutritional supplements or on any weight-loss programs
* Subjects who gained or lost ≥ 3kg weight in the past three months
* Subjects with history of hypo- and hyperthyroidism
* Subjects who are anaemic and those who donated blood within three months of the study
AI Model for Assessing Cardiac Surgeons' Techniques

The goal of this study aims to investigate the use of artificial intelligence to analyze and evaluate the characteristics and proficiency of surgeons during vascular anastomosis in coronary artery bypass grafting (CABG) procedures. The main question it aims to answer is:

Consistency assessment between AI evaluation scores and human expert evaluation scores for surgeons during left anterior descending (LAD) artery anastomosis.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years
* Undergoing internal mammary artery-to-left anterior descending artery bypass grafting
* First-time recipient of isolated CABG surgery
* Signed written informed consent

Exclusion Criteria:

* Patients with acute coronary syndrome
* Patients with contraindications to coronary CT angiography or coronary angiography
* Patients with renal insufficiency or active liver disease, including those with persistently elevated serum transaminases of unknown cause or any serum transaminase levels exceeding three times the upper limit of normal.
Grip Movement Training for Adults With Fine Motor Limitation

This study is to test the system composed by a 3D virtual environment, attached to the Leap Motion, evaluating its effects on the rehabilitation of hand movements in patients with motor alteration.

In order to elaborate the virtual environment, softwares for 3D content creation were used. The virtual environment is formed by four phases, each one having three spheres that are supposed to be inserted, one by one, into a hole located on the scenario floor. Each phase presents a level of difficulty, from pushing the object to performing the grip movement. By the end of each phase, a log file is generated with the time spent on it.

Eligibility Criteria:
Inclusion Criteria:

* men and women with age equal or higher than 18 years old;
* having clinical diagnosis of neurological pathology;
* presenting fine motor coordination deficit and in grip strength;
* being able to understand instructions in order to perform the tasks of the virtual environment;
* minimum score of 23/24 (from a total of 30) in the Mini-Mental State Examination (MMSE)

Exclusion Criteria:

* Not accepting to participate in this research
Objective and Subjective Outcomes of an Electronic Chest Drainage System

This study is designed to compare the Thopaz chest tube drainage system to the traditional collection chamber system. The Thopaz system is already in clinical use in the United States and throughout the world. As such, this study is not evaluating safety or efficacy of this system both of which have already been demonstrated. This study's primary aim is to determine whether the use of a digital chest drainage system compared with a traditional system affects duration of chest drainage and length of hospital stay.

Furthermore, we aim to determine whether the use of a digital chest drainage system compared with a traditional system increases the total distance of ambulation in the first 48 hours after thoracic surgery and affects overall patient satisfaction in the peri-operative period.

Finally, we want to determine whether the aforementioned outcomes relative to the chest tube drainage systems differ in different parts of the world.


Eligibility Criteria:
Inclusion Criteria:

1. Able and willing to read, understand, and provide written Informed Consent
2. Age range of 18-90 years
3. Patients undergoing a segmentectomy, lobectomy, or bilobectomy. Both open and minimally invasive (thoracoscopic or robotic) resections are acceptable.

Exclusion Criteria:

1. Patients unstable enough to require ICU care upon completion of the resection
2. Redo thoracotomies
Explore the Impacts of One Session Theta Burst Stimulation Over Cerebellum in Adults With Autism Spectrum Disorder

The investigator would like to investigate the impact of theta-burst stimulation over cerebellum in adults with autism spectrum disorder


Eligibility Criteria:
Inclusion Criteria:

* Adults with autism spectrum disorder (≥18 years old), confirmed by Autism Diagnostic Observation Schedule.

Exclusion Criteria:

* Previous or current severe neurological disorder such as epilepsy, visual or hearing impairment.
* Previous or current severe systemic disease such as cardiovascular disease, diabetes or infection.
* Previous or current severe brain injury
* Implementation of metal materials such as pacemaker or medication pump
* Previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse
* Pregnancy
* Individuals with a significant brain abnormality such as intracranial space occupied lesions
* History of brain surgery or nervous system infection, such as meningitis and encephalitis
* Concurrent use of medications which increased the risk of seizure attack
* Participate another clinical trial within one month
* Skin trauma on application site
* Individuals suffering from multiple sclerosis
* Individuals with a large ischemic scar
* Individuals suffering from sleep deprivation during rTMS procedures
* Individuals with a heavy consumption of alcohol
* Current taking antiepileptic drugs
* Individuals with a migraine headache from increased intracranial pressure
* Unable to complete MRI scan

Withdrawal criteria:

* Seizure attack during study period
* Autistic symptoms worsened obviously during study period
* Extreme agitation or irritability during study period
* Participants request
* Take antiepileptic drug during study period
Transpulmonary Pressure Gradients in High Frequency Oscillation

Patients with severe lung conditions occasionally require support with a special ventilator (breathing machine) called the High Frequency Oscillator (HFO). Effective ventilation requires that the pressure generated by the ventilator be as high as possible but not too high as this can damage the lungs. In patients on HFO, there is not a well defined way to measure this pressure. We will insert a small probe into the esophagus of patients on HFO to see if this is an accurate way to measure lung pressures for these patients. A better understanding of these pressures could lead to improved patient care.

Trials have found that the use of lower tidal volumes (6 ml/kg) during conventional mechanical ventilation decreases morbidity and mortality. Compared to conventional ventilation, high frequency oscillation (HFO) is able to provide much smaller tidal volumes (1.1 - 2.5 ml/kg) and thus theoretically may provide additional lung protection. At this time, while trials of HFO in adults have been inconclusive, the use of HFO for the management of ALI/ARDS has become widespread

Patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are critically ill and have a high mortality associated with their illness (approximately 50%). Currently, esophageal pressure monitors are used to optimize inflation pressures and improve oxygenation in conventional mechanical ventilation in patients with ALI/ARDS. With this in mind, the purpose of this study is twofold: (1) demonstrate that esophageal pressure monitors can easily be inserted in patients undergoing HFO and (2) report the transpulmonary pressures in these patients.

Eligibility Criteria:
Inclusion Criteria:

* 19 years of age or older
* Receiving HFO
* Informed Consent Obtained

Exclusion Criteria:

* Esophageal lesions or esophageal surgery within the last 6 months
* Morbid obesity - defined as a Body Mass Index (BMI) \> 40
* Unstable cervical spine injury or cervical spinal cord injury
Intrawound Vancomycin Powder in Spinal Fusion Surgery

Vancomycin powder (for solution for Infusion) will be investigated (off-label usage) in spinal fusion surgery. The powder will be locally administered into to the wound cavity before wound closure.

Hypothesis: Locally applied vancomycin powder leads to a reduction in postoperative surgical site infections

Vancomycin is being widely used as an antibiotic agent for intravenous and topical use. The surgical application of vancomycin powder in Austria is limited as there is no powder with marketing authorization for intraoperative, intrawound usage. Previous reports widely document the application of vancomycin powder for solution for infusion. The powder is not soluted, but instead directly spread throughout the wound surface. Limited data is available for spinal fusion surgery, mostly retrospective studies. Results were promising, but the low evidence level does not allow for a conclusion regarding routine usage. Additional randomized, controlled trials are necessary to further investigate this matter.

This trial aims to investigate Vancomycin powder "Xellia" 1000mg, which has a Marketing authorization, in an off-label usage (intrawound, intraoperatively) in spinal fusion surgery. The investigational medicinal product will be used unmodified.

Eligibility Criteria:
Inclusion Criteria:

* Planned TLIF (transforaminal lumbar interbody fusion) or PLIF (posterolateral lumbar interbody fusion) surgery
* TLIF/PLIF fusion length of one or two motion-segments OR
* One motion-segment TLIF/PLIF in conjunction with one motion-segment decompression surgery or microscopic disc surgery (microdiscectomy)
* Fusions within L1 (first lumbar vertebra) through S1 (sacrum)
* Age of 18-years or older
* Signed informed consent

Exclusion Criteria:

* Preoperative inflammatory or infectious state (C-reactive protein levels above 10mg/l)
* Allergic to vancomycin, teicoplanin or penicillin
* Preexisting auto-immune disease with an impaired immune system
* Current post-traumatic vertebral injury (e.g. vertebral split fracture)
* Preexisting Renal impairment
* Preexisting cochlea damage
* Pregnancy
Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients

Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life. The hypothesis of this study is to examine the relationship between cognitive status and clinical profile (respiratory, sleep quality, nutritional status) in patients with chronic obstructive pulmonary disease in two different moments: exacerbation or stable situation.

Chronic obstructive pulmonary disease is a pathology with a systemic impact with a progressive evolution that is characterized by the presence of chronic airflow obstruction.

Patients with COPD may have problems with cognitive functioning, either globally or in single cognitive domains, such as information processing, attention and concentration, memory, executive functioning and self-regulation.

Several studies have determined the prevalence of cognitive impairment in COPD compared to healthy control subjects, reaching very high levels, 36% of COPD patients with mild cognitive impairment compared with 12 % non- COPD subjects.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of chronic obstructive pulmonary disease with exacerbation or stable.
* Signed written consent.
* Medical approval for inclusion

Exclusion Criteria:

* Heart disease.
* Neurological patients.
* Severe cognitive impairment in order not to complete the assessment.
Night Driving Pilot

Pilot study to evaluate usability of Mesotest II for assessment of night driving capacity of pseudo-phakic patients implanted with aspheric monofocal posterior chamber IOL \*AT.Smart 46LC.

Target Criterion:

Measurement of contrast sensitivity and sensitivity to light under mesopic conditions (Mesotest II, Oculus).


Eligibility Criteria:
Inclusion Criteria:

* Healthy eyes with cataract
* Patient age 50-75 years
* Written Patient Informed Consent
* Assured follow-up examination

Exclusion Criteria:

* Any kind of macula degeneration and impairment of retina (clinical diagnosis)
* Amblyopia
* Intraoperative complications; damaged posterior bag; intraocular haemorrhage
* Astigmatism \> 1.5 D (objective, preoperative)
* Pregnancy or lactation period for female patients
Maxillary Sinus Lift With and Without Self-hardening Biphasic Calcium Phosphate.

This study was carried out to compare the outcome of sinus lift without grafting material, versus the use of moldable, self hardening calcium phosphate biomaterials with simultaneous implant placement.

This study was designed as a randomized controlled clinical trial, the study population consisted of 20 patients with missing maxillary posterior teeth and residual bone height 5-7mm. The sample was selected conveniently according to a list of inclusion and exclusion criteria, the participants were allocated randomly into two equal groups. All patients had sinus lift using piezosurgery device with simultaneous implant placement. In group I, blood clot was the only filling material. In group II, moldable, self-hardening calcium phosphate was the filling material. Clinical and radiographic evaluations were done through 6 months postoperatively.

Eligibility Criteria:
Inclusion Criteria:

* Patients having missing posterior maxillary teeth
* The vertical height between the floor of the maxillary sinus and the alveolar crest ranged between 5 and 7mm,
* Free from maxillary sinus pathologies
* Adequate oral hygiene
* Acceptable interarch space for the prosthesis

Exclusion Criteria:

* Patients with systemic diseases that directly affect the surgical procedure and/ or the healing of the bone
* immunocompromised status
* Alcoholism
* psychiatric disorders
* Parafunctional habits
Online Distance Learning Outcomes Compared to Traditional Classroom Learning in Medicine

To test whether the investigator's educational methodology is associated with increasing learning of participants. The investigators second objective is to test the hypothesis that learning in an online classroom would result in similar outcomes as the traditional classroom.

Subjects will be randomized into a "control" group attending a traditional classroom and a "trial" group of equal numbers participating in an online synchronous Internet streaming classroom.

Main outcome measures: Pre and post multiple choice examinations of Vestibulo-Ocular Reflex (VOR), Movement, Head Turns, Head Tremor, Neurodegeneration, Inferior Olivary Complex, Collateral Projections, Eye Movement Training, Visual Saccades, Head Saccades, Visual Impairment, Walking Speed, Neuroprotection, Autophagy, Hyperkinetic Movement, Eye and Head Stability, Oscilllatory Head Movements, Gaze Stability, Leaky Neural Integrator, Cervical Dystonia, Interstitial Nucleus of Cajal (INC) and Head Tilts, Visual Pursuits, Optokinetic Stimulation, Vestibular Rehabilitation.

Methods: All candidates will take a pretest examination of the subject material. Two 9-hour and one 8-hour sessions over 3 consecutive days will be given live in the classroom or synchronously in the online classroom using the Adobe Connect e-learning platform. Subjects randomized to the online classroom will attend the lectures in a location of their choice and will view the sessions live on the Internet. A posttest examination will be given to all candidates after completion of the course.

Eligibility Criteria:
Inclusion Criteria:

* Licensed Health Care Professional, Active Practice

Exclusion Criteria:

* Non Licensed Health Care Professional, Non Active Practice
Randomized Trial of Risedronate to Prevent Bone Loss in Renal Transplant Recipients.

Patients with kidney failure have underlying bone disease at the time of transplant. Fractures of various bones can be as high as 22%. Medication required for the transplant plays a role in bone loss.

Bisphosphonates are used in the general population to treat bone loss of osteoporosis and steroid-induced bone loss. While previous studies, using various bisphosphonates, have shown preservation of bone mineral density in renal transplant recipients, we have demonstrated that pamidronate, a second generation bisphosphonate, is associated with low bone turnover while still preserving bone mineral density. Improved bone mineral density is associated with decreased fracture risk in the general population, while low bone turnover may be associated with increased fracture in dialysis patients.

The purpose of this study is to determine whether risedronate, a third generation bisphosphonate, is effective in preserving bone density when given prophylactically following renal transplantation and whether it is associated with low bone turnover at one year following renal transplantation.

Participants who receive a living donor kidney transplant undergo a bone biopsy at the time of kidney transplant and after one year of protocol. Once adequate kidney function is established, both groups take by mouth a weekly capsule (the control group has a placebo; the treatment group has risedronate 35 mg). Both groups undergo baseline, 6 month and 12 month dual energy x-ray absorptiometry (DEXA) bone mineral density scans. Both groups undergo bone hormonal studies at regular intervals.

Eligibility Criteria:
Inclusion Criteria:

* Adults with end stage renal disease who are undergoing living donor kidney transplantation
Short Pulse Width Versus Low Frequency DBS in Parkinson's Disease

The aim is to compare the effect of reducing the conventional pulse width or frequency of stimulation for axial symptoms occurring after Subthalamic nucleus Deep Brain Stimulation (STN DBS) treatment. The participants will be assessed with chronic stimulation with conventional stimulation parameters, namely 60 us and 130 Hz, and after random allocation to short pulse width (30 us) or low frequency (80 Hz).

STN-DBS implanted patient frequently develop axial symptoms, such as gait and speech disorders, after this surgical procedure, which dampens long-term quality of life of Parkinson's disease patients. The pathogenesis is not completely understood, as it could be either due to a long-term stimulation side effect or a symptom with later onset in disease progression which is not well controlled with actual stimulation program. In case of freezing of gait onset in STN-DBS, literature suggest reducing stimulation frequency. Although, low pulse width is a promising option to tackle speech disorders after STN implant, it is not known its potential therapeutic potential on freezing of gait.

The aim of this investigation is to compare the effect of low frequency and short pulse width stimulation in patients, who develop axial symptoms during long-term follow-up in chronic conventional STN DBS.

As per protocol, participants will be assessed at baseline with chronic standard stimulation parameters (60 us and 130 Hz) then they will be randomly allocated either to a low-frequency (80Hz) or a low-pulse arm (30 us). The study is designed such that after scheduled re-assessment the participant will be switched from low frequency arm to short pulse width and vice versa according to the crossover nature of protocol design. Both the rating investigator and the participant are blinded to the allocation, whereas an unblinded investigator will modify the parameters according to allocation arm.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of Parkinson's disease
* Subthalamic Nucleus Deep Brain Stimulation with chronic conventional stimulation at 60 usec and 130 Hz for at least 3 months
* Movement Disorder Society UPDRS part III 3.11 \>1
* Freezing of Gait Questionnaire item-3 \>1
* Movement Disorder Society UPDRS part III 3.1 \>1
* Montreal Cognitive Assessment \> 26
* No psychiatric disorders
* All patients will be ≥ 18 years of age
* Documented informed consent

Exclusion Criteria:

* no documented informed consent
* axial disorders not related to Parkinson's disease