cyrilzakka/clinical-trials huggingface dataset:
The Effect of Combined Cryotherapy and Immunotherapy on Systemic T Cell Changes and Clinical Outcomes in Metastatic Non-small Cell Lung Cancer

Lung cancer remains one of the most commonly diagnosed oncological diseases worldwide and the first in terms of mortality. Although immune checkpoint inhibitors form the backbone of current metastatic non-small cell lung cancer treatments, there is still no ideal predictive marker for its efficacy and patients still achieve suboptimal results in overall response and survival. While immune checkpoint inhibitors are known to shift systemic anti-tumor immune response from suppression to stimulation in some patients, the investigators hypothesize that this effect can be further enhanced by cryotherapy, especially in "cold" tumors. If proven successful, cryotherapy in combination with immunotherapy, could potentiate a more powerful immune response compared to systemic therapy alone, improve overall response rate, patients' survival without disease progression, and overall survival. The investigators, therefore, aim to use combined local tumor cryotherapy, combined with immune checkpoint inhibitor therapy to induce and evaluate systemic anti-tumor T lymphocyte response and achieve improved non-small cell lung cancer patient outcomes than with immunotherapy alone.


Eligibility Criteria:
Inclusion Criteria:

* Patients with Eastern Cooperative Oncology Group (ECOG) performance score 0 - 1;
* Patients with histologically confirmed metastatic non-small cell lung cancer and PD-L1 expression on tumor cells was evaluated;
* CT examination shows measurable tumor formations according to the RECIST 1.1 criteria;
* Primary lung tumor or metastasis accessible to flexible bronchoscopy;
* Patients may have received surgery, adjuvant or neoadjuvant chemotherapy prior to the study if it was completed at least 12 months before relapse;
* Patients informed about the purpose and course of the study and provided a written consent to participate.

Exclusion Criteria:

* Patients who refused to participate in the clinical trial and did not sign the informed consent form;
* Men and women under the age of 18, pregnant women;
* Patients belonging to a vulnerable social group;
* High risk of general anesthesia, defined as American Society of Anesthesiologists (ASA) class 4 - 6;
* Documented allergy to medications used during general and local anesthesia, systemic cancer treatment;
* Patients previously treated with immune checkpoint inhibitors;
* EGFR mutations or ALK translocations have been identified in patients;
* Patients with previously diagnosed autoimmune diseases, active viral hepatitis, uncontrolled human immunodeficiency virus (HIV) infection or untreated tuberculosis;
* Patients treated with immunosuppressive drugs, systemic corticosteroids, with equivalent doses of prednisolone exceeding 10 mg/day;
* Patients with an increased risk of bleeding during an interventional procedure;
* Acute untreated conditions that would make it impossible to perform an interventional lung procedure.
Dry Needling in Multiple Sclerosis

The investigators are doing this study to see if a treatment called dry needling improves muscle spasticity (muscle tightness) in people who have Multiple Sclerosis. Dry needling involves using tiny needles, like those in acupuncture, to target some muscles, like calf muscles. It differs from traditional acupuncture as it focuses on treating or managing muscle spots, aiming to reduce muscle stiffness and pain. Dry needling may offer a minimally-invasive and medication-free approach to improve muscle spasticity. The investigators hope to see if dry needling also helps enhance balance and walking abilities. This might provide potential improvements inoverall mobility and balance.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 to 64 years
* Clinical diagnosis of Multiple Sclerosis based on the McDonald Criteria
* Spasticity in their lower legs
* Patient Determined Disease Steps (PDDS) score of 5 or below

Exclusion Criteria:

* Inability to communicate effectively with study personnel
* Needle phobia
* Severe varicose veins
* Presence of an active implanted device
* Pregnancy
* Any active cancer or history within 1 year
* known or suspected infection at the site of needling or in the surrounding area
* Presence of a fixed plantarflexion contracture at the ankle
* Acute fracture of dislocation in the region (bilateral lower extremity)
* Deep vein thrombosis or peripheral vascular disease
* Thrombophlebitis, or active osteomyelitis in the region (bilateral lower extremity)
* Any medication changes, including antispastic medicines, for the past three months.
Influence of Modern Colon Hydrotherapy on Intestinal Transit

A randomised and controlled trial, in which the effect of Modern Colon Hydrotherapy is evaluated in the gastrointestinal transit of subjects with functional constipation

The aim of the present randomized randomised and controlled trial is to evaluate the effect of Modern Colon Hydrotherapy in the gastrointestinal transit of subjects with functional constipation.

Two intervention groups were used, to which this type of treatment was applied and to which the intake of a product with prebiotic and prebiotic properties or a placebo was added, depending on the assigned group.

Eligibility Criteria:
Inclusion Criteria:

* Patients between 20 and 60 years of age with functional constipation of more than 5 years of evolution.

Exclusion Criteria:

* Taking any type of antibiotic in the last month
* Taking prebiotics or probiotics products in the last month.
* Taking laxatives in the last month.
* Undergoing any medicinal treatment
* Pregnancy
* Subject with a history of current gastrointestinal pathology or disorder such as: acute colon pathology, acute haemorrhagic colitis, suspected digestive perforation, recent abdominal surgery, severe arterial hypertension, abdominal hernia, colon neoplasia, history of cardiac syncope, renal failure, liver cirrhosis, epilepsy, severe psychiatric illness (psychosis), necrosis due to abdominal irradiation, severe anaemia, severe neurovegetative lability.
Comparison of the Effect of Liraglutide in Young Versus Elderly Healthy Volunteers

This trial is conducted in Europe. The aim of this trial is to compare the exposure of liraglutide in young versus elderly healthy subjects.


Eligibility Criteria:
Inclusion Criteria:

* Good general health as judged by the investigator, based on medical history, physical examination including 12-lead ECG (electrocardiogram), vital signs, and blood and urinary laboratory assessments
* Age, young subjects: age 18-45 years (both incl.)
* Age, elderly subjects: age at least 65 years
* Body Mass Index (BMI) 18-30 kg/m\^2 (both incl.)
* Blood pressure, young: Diastolic 50-90 mmHg, systolic 90-140 mmHg
* Blood pressure, elderly: Diastolic 50-95 mmHg, systolic 92-160 mmHg

Exclusion Criteria:

* History of any clinically significant renal, hepatic, cardiovascular, pulmonary, gastrointestinal, metabolic, endocrine, haematological, neurological, psychiatric disease, or other major disorders that could interfere with the objectives of the trial, as judged by the investigator
* Impaired renal function
* Any clinically significant abnormal ECG (electrocardiogram)
* Active hepatitis B and/or active hepatitis C
* Positive HIV (human immunodeficiency virus) antibodies
* Febrile illness within 5 days prior to first administration of liraglutide
* History of alcoholism or drug abuse during the last 12 months
* Smoking of more than 10 cigarettes per day, or the equivalent for other tobacco products
* Habitual excessive consumption of methylxanthine-containing beverages and foods (coffee, tea, soft drinks such as cola, chocolate) as judged by the investigator
Randomized Phase III Study Of Exemestane (Aromasin) For 5 Years Versus Tamoxifen for 2.5 to 3 Years Followed By Exemestane

To compare the effects of exemestane for 5 years versus tamoxifen and exemestane given sequentially over 5 years in the adjuvant treatment of postmenopausal women with early breast cancer.

This Pfizer sponsored trial is part of an international collaboration of investigators conducting 7 similar yet independent studies in 9 countries. This study is designed to be part of the larger TEAM trial where the data from these 7 studies will be combined. A pre-specified analysis of the pooled data will be conducted.


Eligibility Criteria:
Inclusion Criteria:

* Histologically/cytologically confirmed adenocarcinoma of the breast, followed by adequate surgical resection and/or radiotherapy, and/or adjuvant chemotherapy, if indicated.
* Stage T1-3 N0-2 Mo, Any TNM stage BC for whom adjuvant hormonal therapy is being considered.

Exclusion Criteria:

* Those patients not deemed to have had potentially curative primary surgical treatment or one of the following criteria:
* Inflammatory breast cancer
* Histologically positive supraclavicular nodes
* Ulceration/infiltration of local skin metastasis
* Neoadjuvant chemotherapy
* Ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) without invasion
* ER and PR negative primary tumor or ER/PR unknown status.
Warning Model of Myocardial Remodeling After Acute Myocardial Infarction Using Multimodal Feature Structure Technology

Acute myocardial infarction (AMI) is one of the most important diseases threatening human life. The existing MI prognosis prediction scales mostly predict the incidence of death, recurrent MI and heart failure through 6-8 clinical text indicators, and the data are collected relatively simply. Myocardial remodeling, as an adverse pathological change that can start and continue to progress in the early stage after myocardial infarction, is the main pathological mechanism of heart failure and death. However, there is no quantitative early-warning model of myocardial remodeling, and the clinical guidance of early intervention is lacking.

Our previous study found that cardiac magnetic resonance imaging can accurately quantify the necrotic area and recoverable myocardium in the edematous myocardium after myocardial infarction. In this study, machine learning algorithm, variable convolution network (DCN) and capsule network (capsnet) are used to build a new neural network architecture. Structural feature extraction of multi-modal clinical image data such as MRI and ultrasound is realized. Combined with the established database of 3000 patients with myocardial infarction, the multimodal feature matrix will be constructed, and a variety of classifiers such as support vector machine (SVM) and random forest (RF) will be used for quantitative prediction of myocardial remodeling, and the effects of different classifiers were evaluated. It is expected that this project will establish a quantitative early warning model of myocardial remodeling after acute myocardial infarction in line with the characteristics of Chinese people. The same type of data outside the database will be used for verification to establish an efficient and stable early warning model.


Eligibility Criteria:
Inclusion Criteria:

* 1.Patients with acute myocardial infarction, aged 18-80 years; 2.The time from onset to treatment is less than 72h 3.Myocardial enzyme Tni/Tnt(+).

Exclusion Criteria:

* 1.Patients with malignant tumors; 2.Patients who could not receive conventional treatment 3.Patients who did not receive coronary angiography, lacking anatomical and imaging data; 4.Patients who have undergone cardiac surgery (except coronary artery bypass surgery)
A Non-inferiority Randomized Controlled Trial to Evaluate Promoting Condom Use Among MSM and Transgender Individuals in China

This is a pragmatic, non-inferiority, randomized controlled trial comparing the effectiveness of two methods (crowdsourcing versus social marketing) for creating one-minute videos promoting condom use among MSM and TG in China. Crowdsourcing is the process of shifting individual tasks to a large group, often involving open contests and enabled through multisectoral partnerships.

Crowdsourcing may be a powerful tool to spur the development of innovative videos to promote condom use among key populations such as men who have sex with men (MSM) and transgender (TG) individuals. The purpose of this randomized controlled trial is to compare the effect of a crowdsourced video and a social marketing video on condom use among Chinese MSM and TG who report condomless anal sex during the past three months. The crowdsourced video was developed using an open contest, formal transparent judging, and several prizes. The hypothesis is that a crowdsourced video will not be inferior (within a margin of 10%) to a social marketing video in terms of condomless sex at three to four weeks (with an additional follow-up at three months) of watching the video.

Eligibility Criteria:
Inclusion Criteria:

* The target population for the condom use substudy is males, 16 years of age or older, who were born biologically male or are transgender, have had condomless sex in the past three months and are willing to provide their cell mobile number.

Exclusion Criteria:

* Females
Evaluation of the Aesthetic Outcomes of the Single Crowns Supported by Tissue Level Implants

The aim of this study is to review the long-term soft tissue stability and the long-term esthetic results of single crowns supported by tissue level implants placed in non-augmented healed sites.

The hypothesis of the present study is that tissue level implants can achieve ideal esthetic outcomes in non-augmented healed sites.

Both successful implant-supported restorations and the peri-implant soft and hard tissues are vital determinants which may affect the short- and long-term aesthetic outcomes.

For this reason, the pink aesthetic score (PES) was introduced for the evaluation of peri-implant soft tissues by Fürhauser in 2005 and modified by Belser as PES/WES in 2009.

So far, a series of clinical studies have confirmed the suitability of PES/WES and PES index for the objective outcome assessment of the aesthetic dimension of anterior single-tooth implants.

However, to our knowledge, studies with long term data of the aesthetic outcome evaluation in non-augmented healed sites of the anterior maxilla are still rare, for most of the papers published recently mainly focused on immediate implant placement after tooth extraction with only 1-5 years following up.

In our previous study, we have evaluated the alterations of soft tissue around implant-supported single crowns in the anterior maxilla with original standard PES at the time of crown placement and 6 months post-loading .We have found that the aesthetic outcome of soft tissue around the single-tooth implant had improved significantly at follow-up compared with baseline according to PES assessment. However, the follow up time of the previous study was short (6-8 months), long time follow up is necessary to confirm the previous hypothesis and observations.

Eligibility Criteria:
Inclusion Criteria:

* Have had the tooth extraction at least 3 months before implant surgery.
* Did not receive soft or hard tissue augmentation before or in conjunction with implant surgery.
* Did not receive restorative treatment of the adjacent teeth.
* Underwent conventional healing and loading protocol after implant surgery.
* Have both neighboring teeth and corresponding teeth in the mandible.

  ----For additional, the patients should have
* Photographs of the anterior teeth, the photos should have been taken at right after crown placement and at the 6-10 months recall visit.
* Radiographs of the implant-supported single crowns, the radiographs should have been taken at right after crown placement.

Exclusion Criteria:

* Patients who don't fulfill the inclusion criteria
* Patients who refused to join the study
Flash Glucose Measurement in Patients on Total Parenteral Nutrition

IV nutrition is a means of providing all the nutritional requirements of people who have severe bowel disease. At least 10% of people on longer term IV nutrition also have diabetes and IV nutrition includes delivering glucose directly to large veins. Unsurprisingly this causes elevated blood glucose levels, particularly in people with diabetes. This can make treatment of hyperglycaemia more challenging. As a result this study aims to use a flash glucose monitoring device, the FreeStyle Libre pro, to investigate what happens to glucose levels in patients receiving IV nutrition. We will look at this trend in 5 patients with diabetes and 5 patients without diabetes receiving IV nutrition.


Eligibility Criteria:
Inclusion Criteria:

* Participants receiving TPN in Leeds with or without diabetes

Exclusion Criteria:

* Patients not receiving TPN
* Patients who do not speak English
* Patients who are unable to give consent
Contrast-Enhanced Ultrasound Identification of Sentinel Nodes in Esophageal Cancer

This pilot trial studies how well an ultrasound with a contrast agent (perflubutane microbubble \[Sonazoid\]) works in identifying sentinel lymph nodes in participants with esophageal cancer. Sentinel lymph nodes are lymph nodes to which the cancer is likely to spread from the primary tumor. Diagnostic procedures, such as contrast-enhanced ultrasound, may work better in identifying sentinel lymph nodes and finding out how far the disease has spread.

PRIMARY OBJECTIVES:

I. To assess the accuracy of contrast-enhanced endoscopic lymphosonography guided fine-needle aspiration (FNA) of sentinel lymph nodes compared with unenhanced endoscopic ultrasonography (EUS) guided FNA in the characterization of esophageal cancer-associated lymph nodes using pathology as the reference standard.

SECONDARY OBJECTIVES:

I. To assess the ability of contrast-enhanced endoscopic lymphosonography guided FNA compared with unenhanced EUS guided FNA in the overall detection of biopsy proven cancer-involved sentinel lymph nodes.

II. To assess the impact of overall tumor staging by contrast-enhanced endoscopic lymphosonography compared with unenhanced EUS.

Eligibility Criteria:
Inclusion Criteria:

* Newly diagnosed with esophageal cancer.
* Be scheduled for staging endoscopic ultrasound with the intent for lymph node evaluation.
* Provide signed and dated informed consent form.
* Willing to comply with all study procedures and be available for the duration of the study.
* Be medically stable.
* If a female and pre-menopausal, must have a negative pregnancy test.

Exclusion Criteria:

* Females who are pregnant or nursing.
* Patients with other primary cancers requiring systemic treatment.
* Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable.
* Patients with known hypersensitivity or allergy to any component of Sonazoid.
* Patients with cardiac shunts or unstable cardiopulmonary conditions.
* Patients with congenital heart defects.
* Patients with severe emphysema, pulmonary vasculitis, pulmonary hypertension, respiratory distress syndrome, or a history of pulmonary embolism.
Retrospective Evaluation of the Effect of Ultrasound-guided Obturator Nerve Block on Complications in Transurethral (TUR-M) Resection Surgery for Bladder Side Wall Tumors.

In this study, the effectiveness of obturator nerve block added to spinal anesthesia in the operation of transurethral resection (TUR-M) of bladder lateral-infrolateral wall tumors on the obturator reflex and related complications was investigated.


Eligibility Criteria:
retrospective study

Inclusion criteria:

* Patients over the age of 18 who have undergone bladder tumor surgery and whose anesthesia method is spinal anesthesia

Exclusion Criteria:

* under 18 years old , received general anesthesia pregnant and pediatric patient data not used
A Therapeutic Equivalence Study of Two Oxiconazole Nitrate Topical Cream Treatments for Patients With Tinea Pedis

The objective of this study is to demonstrate that Oxiconazole nitrate 1% topical cream is effective for the treatment of patients with moderate to severe Tinea pedis.


Eligibility Criteria:
Inclusion Criteria:

1. Male or non-pregnant, non-lactating female, 12 years of age or older.
2. Signed informed consent form, which meets all criteria of current FDA regulations
3. If female and of child bearing potential, prepare to abstain from sexual intercourse or use a reliable method of contraception during the study {e.g., condom, IUD, oral, transdermal, injected or implanted hormonal contraceptives)and (must have used the same product for at least 30 days prior to the study start and use the same product throughout the duration of the study), transdermal or implanted hormonal contraceptives}
4. A confirmed clinical diagnosis of tinea pedis with lesions localized to the interdigital spaces or predominantly interdigital, but may extend to other areas of the foot. (the non-interdigital lesions should not be hyperkeratotic i.e., characteristic of moccasin).
5. The presence of tinea pedis infection, confirm by the observation of segmented fungal hyphae during a microscopic KOH wet mount examination.

Exclusion Criteria:

1. Females who are pregnant, or lactating or likely to become pregnant during the study.
2. Any known hypersensitivity to oxiconazole nitrate or other antifungal agents.
3. Patients with a past history of tinea pedis infections with a lack of response to antifungal therapy (i.e. recurrent tinea pedis, more than 3 infections in the past 12 months, which were unresponsive to previous antifungal therapy).
4. Participation in a research study in the past 30 days prior to screening/randomization.
Polyamine-low Diet to Prevent Postoperative Pain After Cholecystectomy

It has been shown that N-methyl-D-aspartate (NMDA) receptor antagonists (such as ketamine) potentiate analgesic drug's efficacy. Polyamines are allosteric modulators of NMDA receptors. In animal studies, polyamine-free diet has shown antinociceptive properties. This research aims at evaluating analgesic properties of polyamine-low diet after laparoscopic cholecystectomy performed in an ambulatory setting.


Eligibility Criteria:
Inclusion Criteria:

* laparoscopic cholecystectomy
* ambulatory surgery
* agreeing to follow a polyamine-low diet with Polydol plus

Exclusion Criteria:

* Pregnancy
* Contra-indication to a non-steroidal anti-inflammatory, to tramadol
* Intolerance to cow proteins
* Diabetic patients
* Poor understanding of the French language.
Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer

The purpose of the study is to investigate the effects of metformin in addition to the conventional progestin therapy in the fertility-sparing treatment of early stage endometrial cancer.


Eligibility Criteria:
Inclusion Criteria:

* Endometrial cancer radiologic International Federation of Obstetrics and Gynecology (FIGO) stage IA patients
* Endometrioid endometrial cancer patients
* FIGO cellular differentiation grade 1 patients
* Patients who wish to preserve fertility
* Patients who understand that the recommended treatment of endometrial cancer is surgical treatment even in early stages, but still wish to preserve fertility and avoid surgical treatment
* Patients who have good performance status (Eastern Cooperation Oncology Group (ECOG) performance score equal to or greater than 3)
* Patients who are not contraindicated to the progestin therapy
* Patients who are not contraindicated to the use of metformin

Exclusion Criteria:

* Patients who have already received chemotherapeutic or radiotherapeutic treatments for endometrial cancer
* Patients whose disease is already advanced and not indicated for fertility-sparing treatment
* Patients whose tumor cellular differentiation grade is greater than FIGO grade 1