cyrilzakka/clinical-trials huggingface dataset:
High Flow Oxygen Therapy and Acute Ischemic Stroke

Hypoxemia is common in acute ischemic stroke and associated with neurological deterioration and mortality. However, the benefit of oxygen therapy is controversial. Severity of stroke may affect the benefit of oxygen supplementation. Abnormal breathing patterns are commonly found among stroke patients and may increase the risk of hypoxemia. High flow nasal cannula (HFNC) has several advantages from controllable fraction of inspired oxygen (FiO2), reduction of nasopharyngeal resistance and positive end expiratory pressure effect. In this study, we aimed to assess the therapeutic effect of HFNC on oxygen desaturation index (ODI) and neurological outcomes in stroke patients with moderate and severe severities, compared with no and low flow oxygen supplementation.


Eligibility Criteria:
Inclusion Criteria:

1. Age of 18 or more
2. Clinical and radiographic findings including computerized tomography of brain compatible with acute ischemic stroke
3. Presentation within 72 hours after the stroke onset
4. National of Health Stroke Scale (NIHSS) of 5 or more,
5. Limb weakness defined as motor power grade of 4 or less,
6. Able to give informed consent, or the next of kin was willing to give assent

Exclusion Criteria:

1. Recognized indications for oxygen treatment, such as oxygen saturation on room air of less than 92%, acute left ventricular failure, severe pneumonia, pulmonary emboli, and chronic respiratory failure treated with home oxygen supplementation
2. Recognized contraindications for oxygen treatment including chronic hypercapnia and type II respiratory failure
3. Subjects with previous diagnosis of obstructive sleep apnea (OSA) or highly suspicious of OSA, screened by STOPBANG score of 5 or more
A Study of Subcutaneous Mircera in Participants With Chronic Kidney Disease Not Treated With ESA or on Dialysis

This single arm study will assess the efficacy and safety of subcutaneous Mircera for correction of anemia in participants with chronic kidney disease who are not treated with erythropoiesis stimulating agent (ESA) and not on dialysis. Eligible participants will receive Mircera by monthly subcutaneous injections. The initial dose, based on body weight, will be 1.2 micrograms/kilogram (mcg/kg). The anticipated time on study treatment is 9-11 months, and the target sample size is 100-500 individuals.


Eligibility Criteria:
Inclusion Criteria:

* chronic renal anemia;
* hemoglobin value less than or equal to (\<=) 10.5 grams/deciliter (g/dL).

Exclusion Criteria:

* prior ESA therapy during previous 3 months;
* acute or chronic bleeding requiring therapy during previous 2 months;
* transfusion of red blood cells during previous 2 months;
* active malignant disease (except non-melanoma skin cancer).
Association Between Driving Transpulmonary Pressure and Extravascular Lung Water in Patients with ARDS

Intubated patients with the acute respiratory distress syndrome (ARDS) are usually treated with protective ventilation limiting plateau pressure below 30 centimeter of water (cmH2O) and, if possible, a driving pressure under 15 cmH2O. However, these airway pressures might not reflect the actual pressure applied to the lung. Transpulmonary pressure is the difference between airway pressure and pleural pressure, the latter is estimated by the esophageal pressure, and so it better reflects the ventilatory induced lung injury (VILI).

One of the consequences of the VILI is a increase of pulmonary edema and it could be estimated by the extravascular lung water, obtained by trans-pulmonary thermodilution.

So it could exist a link between the driving trans-pulmonary pressure and the extravascular lung water.


Eligibility Criteria:
Inclusion Criteria:

* Acute respiratory distress syndrome (ARDS)
* Monitoring with a transpulmonary thermodilution device
* Esophageal pressure monitoring

Exclusion Criteria:

* Legal protection measures
* Pregnancy
* Contra-indications of esophageal catheter : esophageal varicose, severe coagulopathy
Evaluation of the Media Detective Program for Elementary School-Aged Children to Prevention Substance Use

The purpose of this study was to determine whether a media literacy education program taught be teacher to late elementary school students (grades 3-5) positively affected students' critical thinking skills and substance use-related health outcomes.

Media Detective is a 10-lesson elementary school, substance abuse prevention program developed based upon the Message Interpretation Processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this study was to conduct a short-term randomized controlled trial study to evaluate the effectiveness of Media Detective for achieving these goals.

Eligibility Criteria:
Inclusion Criteria:

* Must be able to read and write in English

Exclusion Criteria:

* None
Impact of Reinforced Education by Wechat and Short Message Service on the Quality of Bowel Preparation

High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of reinforced education by Wechat or short message service (SMS) on the quality of bowel preparation. This prospective, endoscopist-blinded, randomized, controlled study was conducted. Reinforced education groups received additional education via reminders by Wechat or SMS 2 days before colonoscopy. The primary outcome was the quality of the bowel preparation according to the Boston Bowel Preparation Scale (BBPS). The secondary outcomes included polyp detection rate (PDR), adenoma detection rate (ADR), tolerance, and subjective feelings of patients.


Eligibility Criteria:
Inclusion Criteria:

* aged 18-80 years
* can access to Wechat themselves or through close family members living in the same household

Exclusion Criteria:

* inpatients
* pregnancy
* breast feeding
* history of colorectal surgery
* patients allergic to PEG-ELS based laxatives
Radiofrequency Electromagnetic Fields and Pregnancy : Exposure Specificities and Evolution

The purpose of this study is to investigate the specific features of radiofrequencies (RF) exposure (including 5G) in pregnant women, its evolution during pregnancy and the quantitative contribution of the various RF emission sources to which they are exposed.


Eligibility Criteria:
Inclusion Criteria:

* Pregnant women over 18 years of age;
* Subject not opposed to participating in the study;
* Patient performing the three screening ultrasounds recommended by the French National Authority for Health (HAS) at the Universitary hospital of Besançon during her pregnancy (independently or in addition to on-site clinical pregnancy monitoring); Affiliation with a French social security scheme or beneficiary of such a scheme; Living within the Universitary hospital of Besançon maternity catchment area, to cover the full range of geographical exposure, including both highly urbanized and more rural areas;

Exclusion Criteria:

* Opposition of the subject to participate in the study;
* Discontinuation of pregnancy ultrasound follow-up at Besançon University Hospital, in particular due to relocation;
* Women under court protection, guardianship, curatorship or protective supervision.
Efficacy of Community Reinforcement Approach (CRA) in the Treatment of Cannabis Users

Substance abuse is not a new phenomenon in Pakistan. Its prevalence is increasing day by day due to multi-factorial reasons including psychological, cultural, biological, environmental, social and personal factors. Recent statistics shows an alarming increase in the use of substance. The last survey conducted indicates there are 3.6 million substance users in Pakistan and 3.6 percent among them are cannabis users. Furthermore, cannabis is found to be the most prevalent abused drug with adverse impact on the mental health among university students in Pakistan. However, there is a dearth of literature which could indicate a well-established treatment policy with proven efficacy model available in Pakistan. This study aims to investigate the efficacy of Community Reinforcement Approach (CRA) as evidence based remedy for Cannabis Users. The study is designed in a Randomized Controlled Trial (RCT) consisting of groups: Active Treatment (AT; with nine sessions of CRA intervention) and Treatment as Usual (TAU; routine treatment). After screening and baseline, participants will be assigned to the either Active Treatment group or Treatment As Usual group. Participants in both groups will be assessed on completion of third month after randomization (Outcome assessment), six months after randomization (first follow-up), and finally ninth months after randomization (second follow up). The primary outcome measure will be the frequency of usage, abstinence period and quantity of cannabis by using Timeline Follow Back Interview. The duration of the study is two and half years


Eligibility Criteria:
Inclusion Criteria:

1. Aged 18-30.
2. Current, regular cannabis use, defined as the use of any cannabis product at least twice per week over the course of the past 12 months.
3. Participant able to provide informed consent and willing to participate in the study.

Exclusion Criteria:

1. ICD-11 dependence (in the previous 12 months) on alcohol or any other illicit drug (apart from cannabis) with symptoms of withdrawal, tolerance or craving.
2. Current use of opiate substitution or sedative-hypnotic medication.
3. Having been treated for cannabis use problems with any other treatment within the previous three months.
4. Participant with lifetime psychotic disorder.
5. Participants with moderate, severe and extremely severe scores on (DASS-21) will be excluded. Severe learning disability or a pervasive developmental disorder.
6. Signs of severe non-cannabis-related intoxication.
A 5 Year Clinical Study on NobelActive 3 mm Implants

Multi-centre study evaluating the NobelActive 3.0 mm implant immediately restored with single crowns in the maxillary lateral incisor area or mandibular central or lateral incisor area.


Eligibility Criteria:
Inclusion Criteria:

* Obtained informed consent from the subject.
* The subject shall be at least 18 years of age and have passed secession of growth.
* The subject shall be in need of one or more single tooth implant supported restoration(s) in the maxillary lateral incisor or mandibular central or lateral incisor areas of the mouth.
* The subject shall have natural tooth roots present on both sides adjacent to the implant position.
* The subject must be in such a physical and mental condition that a 5-year follow-up period can be carried out without foreseeable problems.
* The subject shall have sufficient bone volume at the implant site for placing a NobelActive 3.0 mm implant with a length of at least 10 mm.
* The subject as well as the implant site shall fulfill criteria for immediate provisionalization within 24 hours. A minimum insertion torque of 35 Ncm without further rotation is required.
* The implant site shall be free from tooth remnants.
* If the implant is placed in an extraction site, the extraction socket should have at least 3 intact walls. A dehiscence defect of up to 3 mm is permitted on the fourth wall.
* If the implant is placed in an extraction site, proper and thorough debridement of the extraction socket should be performed.
* The subject shall be healthy and compliant with good oral hygiene.
* The subject shall have a favorable and stable occlusal relationship.

Exclusion Criteria:

* The subject is not able to give her/his informed consent of participating
* Health conditions, which do not permit the surgical treatment.
* Reason to believe that the treatment might have a negative effect on the subject's total situation (psychiatric problems), as noted in subject records or in subject history.
* Any disorders in the planned implant area such as previous tumours, chronic bone disease or previous irradiation.
* Teeth in positions adjacent to the implant site with ongoing infections, endodontic or peri-odontal problems.
* Alcohol or drug abuse as noted in subject records or in subject history.
* Heavy smoking (\>10 cigarettes/day).
* Uncontrolled diabetes, i.e. a subject with diagnosed diabetes that has a history of neglecting doctor's recommendations regarding treatment, food and alcohol intake.
* Any other disease or medication that might have an influence on the involved tissues, such as intake of bisphosphonates, treatment with heparine, osteogenesis imperfecta, osteoporosis etc.
* Severe bruxism or other destructive habits.
* If the implant is not able to withstand a final torque of 35 Ncm without further rotation, or if the implant for any other reason cannot be immediately provisionalized, as judged by the clinician, the implant will be excluded from the study.
Pressure Ulcer Healing With Microcyn

The purpose of this study is to test how well Microcyn™ works on Stage 3 and Stage 4 pressure ulcers compared to sterile saline among persons with spinal cord injury.


Eligibility Criteria:
Inclusion Criteria:

* Age \> 17 years
* Persons with spinal cord injury
* Having Stage III/IV pressure ulcer(s)
* Able to fulfill all obligations of the study

Exclusion Criteria:

* Pressure ulcers scheduled for surgical closure within 14 days
* Use of any immunosuppressant medications within 30 days of screening
* Having conditions that put the subject at significant risk
* Medically unstable or has a life expectancy of less than 12 months
* Current enrollment in an investigational drug or device study or participation in such a study within the last 30 days
* Pregnant women
Prognostic Value of Estimated Plasma Volume in Pulmonary Hypertension

Assessment of the prognostic value of the estimation of plasma volume or its variation in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) after acute right heart failure.

The aim of the study is to show that a low plasma volume status, assessed by the Strauss (estimated plasma volume variation) and the Duarte (instantaneous estimated plasma volume) formulas evaluated during acute right heart failure in patients presenting with PAH or CTEPH, is associated with better long-term outcomes.

Optimization of plasma volume is important for patients with PAH and CTEPH and constitutes a prognostic factor. However, plasma volume status can be difficult to assess in clinical practice. Different formulas have been developed and have shown interest in patients with congestive heart failure with an association between plasma volume estimation and long-term prognosis.

Acute right heart failure may occur in patients with PAH and CTEPH. Thus, the investigators plan to study the prognostic value of these formulas evaluating plasma volume, in patients with PAH or CTEPH, after acute right heart failure.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with confirmed diagnosis of PAH or CTEPH, referred to the medical department of the investigators
2. Patient with acute right heart failure defined by at least 2 of the following clinical features: worsening of peripheral oedema, development or increase of ascites, weight gain of more than 2.5 kg in 1 week preceding the visit and decline in one NYHA functional class compared to the previous stable state

Exclusion Criteria:

1) Patients with another cause of pulmonary hypertension than PAH or CTEPH, either groups 2, 3 or 5 of the current clinical classification of pulmonary hypertension
Improving Human Ovarian Transplantation

we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.

Ovarian tissue is removed by laparoscopy and only in patients facing premature ovarian failure due to chemotherapy.Tissue for research will consist either of a small portion (\<10%) of the cortex for preservation for young women. another source of ovarian tissue for research will be obtained following consent from family of patients who have died of the disease and have previously frozen ovarian tissue.

Eligibility Criteria:
Inclusion Criteria:

* tissue previously obtained

Exclusion Criteria:

* no tissue available or no consent
Evaluation of Diagnostic Performance of Cerebral Perfusion Scans in Pseudo-Stroke

When a patient is received with the context of acute stroke, they undergo a fast neurological evaluation and obtain a basic appraisal composed of a non-contrast endovascular cerebral scan and an angiography scan of intracranial blood vessels and the neck. Once the structural lesion (hemorrhage, tumor, etc.) is absent, signs of early infracts and confirmed acute intracranial arterial occlusion, the possibility of a pseudo-stroke dwells in the differential diagnostic.

Certain characteristics of history and clinical evaluation create sufficient doubt to evoke the possibility of a pseudo-stroke. In fact, this population is mostly female and the cardiovascular risk factors are less prevalent in this group than for the group of stroke victims. It is on average the youngest and presents a less severe deficit. For the rest, medical antecedents often help to evoke a diagnosis of pseudo-stroke.

With this study, the investigators wish to evaluate the diagnostic value of two additional radiological examinations:

1. Computed tomography perfusion (CTP) imaging to evaluate blood flow in the brain;
2. Imaging by magnetic resonance (MRI) of the brain to detect lesions from a cerebral vascular accident (stroke) not visible on standard imaging of the brain.

The proposed additional examinations (CTP and MRI) are tests that are currently used at the CHUM. Those are not experimental tests. These tests are commonly used when doctors wants a further investigation to clarify the cause of the neurological symptoms. These tests are usually done in a semi-urgent or non-urgent situations. In the present study they will be done urgently. The investigators wish to determine if obtaining these additional tests in emergency will change the decision of whether to administer the drug (thrombolysis). The investigators want to determine whether one imaging test is sufficient or if both exams are needed to help clinical decision-making. Please note that urgent access to perfusion CT and brain MRI is not considered routine care, since the value of these additional tests has yet to be demonstrated.

Eligibility Criteria:
Inclusion Criteria:

1. Admission at CHUM for acute neurological deficit \<4,5h (since the onset of symptoms)
2. Potential candidate for an intravenous thrombolysis
3. Cerebral angioscan performed at CHUM at the time of admission
4. Age ≥ 18 years
5. Observed period from September 2019 à June 2020

Exclusion Criteria:

1. Contraindication to intravenous thrombolysis according to the doctor in charge of treatment;
2. Indication of a thrombectomy;
3. Incomplete exam or exam of insufficient technical quality for a reliable radiological interpretation;
4. Contraindication against MRI .
Evaluation of Plenum® Tissue Ortho to Prevent Epidural Fibrosis and Post-laminectomy Syndrome.

The goal of this clinical trial is to compare if adding a polydioxanone membrane prevents epidural fibrosis and, consequently, the rate of occurrence of the post-laminectomy syndrome in participants undergoing microdiscectomy for treatment of disc herniation.

Participants will be submitted to microdiscectomy with the addition of a polydioxanone membrane over the dura mater in the test group and without in the control group.

The groups will be compared regarding improving patients' quality of life, evaluation of epidural fibrosis, and device safety.

Eligibility Criteria:
Inclusion Criteria:

* Pain radiating to one of the legs confirmed with an MRI scan;
* Patients who have already undergone conservative treatment (treatment with medication and physiotherapy) for at least 6 weeks, but have not shown improvement;
* Non-pregnant women or women of childbearing age who use contraceptive methods;
* Having signed the free and informed consent form (TCLE).

Exclusion Criteria:

* Patients with concomitant pathologies (eg infection or tumor and segmental instability or vertebral fractures);
* Cauda equina syndrome;
* Strength deficit characterized by strength equal to or less than III/V;
* Previous surgery of the lumbar spine;
* Patientes who have wound healing disorders;
* Patients with contraindications for evaluating MRI with the use of contrast;
* More than 1 herniated disk.
Patient Outcomes Collection: How Can we do Better?

Patient reported outcomes (PROs) are widely used by clinical providers as important tools to help inform their clinical and research practice, and to improve quality of care for patients. In this study, the investigators aim to investigate ways by which patient PRO completion rates may be improved.

Patient reported outcomes (PROs) are widely used by clinical providers as important tools to help inform their clinical and research practice, and to improve quality of care for patients. In addition, PROs are increasingly cited as a tool in measuring surgical performance and the value of health care services being delivered. The quality of data captured by PROs is, however, largely dependent on patients' response rates, both pre- and post-operatively. For pre-operative surveys, higher response rates may be achieved as patients may be reminded to complete their surveys at an office visit or prior to surgery. However, patient non-compliance presents a major challenge post-operatively, undermining PRO data integrity.

As clinical practices have moved to using PROs for all patients, rather than just a research tool, automated systems have been developed to deliver and collect PRO electronically. However, while automation has helped streamline PRO administration and data collection, this hasn't always translated into obtaining better PRO compliance rates. In an attempt to improve response rates, efforts have been made to reduce patient burden (by reducing the number of questions asked, for example), to regularly remind patients to complete their forms (either by email or telephone), or even offer patients monetary or non-monetary incentives.

Despite these measures' variable success, however, achieving high response rates remains a challenge. This, in part, is due to the fact these platforms depend heavily on patients receiving the request and their willingness to participate in the program, often long after their care is completed. As data are increasingly used to measure physician performance and quality, as well as to determine reimbursement, low patient compliance rates remain a significant impediment and affect the validity of the data.

In this study, the invetigators hypothesize that direct patient engagement can improve patient compliance with automated PRO capture.

Eligibility Criteria:
Inclusion Criteria:

* Patients scheduled to undergo shoulder arthroscopy for rotator cuff condition (sub-acromial decompression, distal clavicle resection, biceps tenodesis, partial or full thickness rotator cuff tear repair or debridement) will be eligible for enrollment in the appropriate cohort. There will be no restrictions to this enrollment apart from that presented in the exclusions below.

Exclusion Criteria:

1. Minors or those over the age of 80
2. Subjects lacking English proficiency to complete the PROs of interest.
3. Past or current medical history that would preclude patients from undergoing surgery.