cyrilzakka/clinical-trials huggingface dataset:
The Effectiveness of Muscle Energy Technique and Friction Massage in Hamstring Tightness Amongst Young Athletes of Pakistan

The ability of an individual to move smoothly depends on his flexibility, an attribute that enhances both safety and optimal physical activity. Hamstring tightness leads to hamstring injuries and hamstring injuries are the most common type of injury among athletes. These injuries are slow to recover, make high health expenditure and decrease the performance level of the athlete.

The hamstring is an example of the muscle group that has a tendency to get shorten Muscle tightness is caused by a decrease in the ability of the muscle to deform, resulting in a decrease in the range of motion at the joint on which it acts. Inability to achieve greater than 120° of knee extension with the hip at 90° of flexion is considered as hamstring tightness.

it will be a Randomized Controlled Trial with 3 group. there will be 60 patients with hamstring tightness divided into 3 group. Allocating by using the manual lottery system. Non-probability Convenience Sampling technique will be utilized. the self-structured questionnaire will be used to analyse the athletic condition and performance.

Each patient in group A will be given with hot pack along with Tens for 20 mins then the patient will receive post facilitation stretch only, for about one months on daily basis.

Each patient in group B will receive hot pack along with Tens for 20 mins then the patients will receive post isometric relaxation alone for about one months on daily basis.

Each patient in group C will receive hot pack along with Tens for 20 mins then the patients will receive frictional massage alone for about one months on daily basis. Friction massage on hamstrings will be given for 20 mins by thrive massager by a therapist.

Eligibility Criteria:
Inclusion Criteria:

* Athletes with Hamstring tightness
* Both male and female will be included.
* Athletes ages from 18 to 25 years
* Patients having Straight Leg Raise less then110˚

Exclusion Criteria:

* Athletes having hamstring injuries
* Patients having Straight Leg Raise greater then 110 ˚
* Above 25 years of age
* Other orthopedic condition like Low Back Pain,
* Athlete with any deformity Knee Joint
Probiotics in Newly Diagnosed T1D

The investigators aim to further the understanding of environmental factors that underlie the development of Type 1 diabetes (T1D) and the post-onset disease trajectory. Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been hypothesized to increase the risk of developing T1D in those with genetic susceptibility. Dysbiosis may result from modern dietary habits, such as broad consumption of the highly processed Western Diet, or by widespread use of antibiotics. Here, the investigators propose to examine the impact of dysbiosis on the endogenous innate inflammatory state that potentiates T1D progression. The investigators hypothesize that probiotic-induced alterations in the intestinal microbiota may favorably alter the post-onset disease state.


Eligibility Criteria:
Inclusion Criteria:

* Patients must meet all of the following criteria:

  1. Males and females 5-17 years of age with a clinical diagnosis of T1D within the past 90 days
  2. Positive for ≥ 1 diabetes-related autoantibodies (IAA, GAD, IA-2, or ZnT8)
  3. Stimulated C-peptide area under the curve (AUC) of ≥ 0.2 nmol/L during a mixed meal tolerance test
  4. Treatment naïve of any immunomodulatory agent

Exclusion Criteria:

* Patients must NOT meet any of the following criteria:

  1. Probiotic use within 1 month of screening visit
  2. Presence of severe, active disease that requires the use of chronic medication, with the exception of well-controlled autoimmune thyroiditis/hypothyroidism
  3. Diabetes other than T1D
  4. Female participants of child-bearing age with reproductive potential must not be knowingly pregnant
  5. Any condition that, in the investigator's opinion, may compromise study participation or may confound the interpretation of the study results
Omeprazole 20 mg in Patients With Laryngopharyngeal reﬂux and Comorbid Chronic Rhinosinusitis

The hypothesis of this study is that a gastroesophageal reflux recommended treatment with proton pump inhibitor (dose and duration) compared to placebo significantly reduces both the signs and symptoms of laryngopharyngeal reﬂux and comorbid chronic rhinosinusitis. Primary objective was to determine whether 8 weeks of treatment with omeprazole 20 mg ones daily (OD) significantly reduces the signs and symptoms of laryngopharyngeal reﬂux when compared to placebo in patients with laryngopharyngeal reﬂux with comorbid chronic rhinosinusitis. Secondary objectives were to determine whether 8 weeks of treatment with omeprazole 20 mg OD significantly reduces the signs and symptoms of comorbid chronic rhinosinusitis in patients with laryngopharyngeal reﬂux when compared to matching placebo; and to investigate the association of the severity of signs and symptoms of laryngopharyngeal reﬂux with the ones of chronic rhinosinusitis in the same group of patients. The research was carried out as a double blind randomized placebo controlled trial. Patients were randomized into two groups in an approximate 1:1 ratio using a concealed random sequence. After randomization and initial assessment treatment was initialized. Patients on active treatment were given omeprazole 20 mg once daily half an hour before breakfast for 8 weeks, while those in the placebo group were given matching placebo tablets using the same regimen for 8 weeks as the group on the active treatment. Patients were reassessed at the end of treatment for signs and symptoms of laryngopharyngeal reﬂux and comorbid chronic rhinosinusitis.


Eligibility Criteria:
Inclusion Criteria:

* laryngopharyngeal reﬂux
* chronic rhinosinusitis

Exclusion Criteria:

* allergic rhinitis
* asthma
* cystic fibrosis
* nasal polyposis
* severe systemic diseases
Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery

VATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS. The optimal strategy for pain management has not been defined. In this randomized, placebo-controlled, double-blinded clinical investigation, investigators hypothesize that 5 mcg/kg intrathecal morphine will decrease postoperative analgesic consumption and reduce pain.

This is a randomized, placebo-controlled, double-blinded clinical trial. Patients will be randomized into one of two groups. Group A (Placebo, control group) will receive intrathecal sterile normal saline and Group B (Morphine group) will receive 5mcg/kg preservative free intrathecal morphine.

American Pain Society Outcome Questionnaire (APS-POQ) will be administered to patients prior to discharge (see data sheet).

Patients will be followed up with a phone survey at 1 and 3 months after surgery to assess the presence, nature, and severity of chronic persistent surgical pain. The Brief Pain Inventory is a reliable and valid measures of the interference of pain with physical functioning and will be used. Additionally patients will be asked about use of pain medications

Eligibility Criteria:
Inclusion Criteria:

* Age 18-80 years old
* Undergoing elective video-assisted thoracoscopic surgery for anatomical lung resection
* General anesthesia with anticipated intraoperative extubation.

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) classification of 4 or 5
* Anticipated postoperative intubation
* Significant liver disease
* Preoperative use of intravenous inotropes and/or vasopressor support
* Preoperative mechanical ventilation
* Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
* Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
* Morphine allergy
* Opioid or alcohol abuse
* Chronic pain
* Renal failure
* Inability to comprehend English language
* Bleeding disorder
* Abnormal preoperative coagulation
* Infection
* Patient refusal
Efficacy and Safety Trial of Subcutaneous Immunotherapy in Mite Induced Asthma

The purpose of this study is to determine whether a short course of subcutaneous immunotherapy is efficacious in mite induced asthma. The efficacy is based on reduction in control medication.

The control of mild-moderate persistent asthma include the need of concomitant medication, as inhaled corticosteroids. However, compliance in perennial asthma is low. The aim of this study is to assess the possibility to reduce the need of concomitant medication through a short-course of subcutaneous immunotherapy.

Eligibility Criteria:
Inclusion Criteria:

* Mild/moderate persistent asthma
* Positive skin prick test or specific IgE to mites
* Age: 14-55 years old

Exclusion Criteria:

* Immunotherapy contraindications
* Allergy to other inhalant allergens
* Previous immunotherapy (5 years)with mites
Viewpoints on the Social Representations and Rationale Concerning the Choices of Patients, Doctors and Caregivers With Regard to the Management of Patients With Non-resectable Metastatic Cancer of the Colon, Stomach, Bile Ducts, Rectum, Pancreas or Lung, or Gastrointestinal Neuroendocrine Tumours

Reflexion on the therapeutic strategies to implement in patients at the end of life is advancing rapidly in France. However, beyond the choices presented to patients, sometimes even the decision to carry on, to limit or to stop treatments is also questioned. This decision is subjective; it is influenced by the patient's representation system (emotions, beliefs, values, practices, etc). In addition, even though he or she is the focus of the decision, the patient is not alone; other actors, accompanying the patient, play an important role in the final decision making. These actors, namely the doctors and close relatives, are also influenced in their decision making. This coexistence of representation systems may interfere with objective indicators that help in decision making (functional, clinical and biological) or with the knowledge acquired by doctors in their training and may complicate the decision-making process.


Eligibility Criteria:
Inclusion Criteria:

I- PATIENTS

* men or women
* who have been informed about the study
* and who have provided verbal consent to take part in the study
* able to understand written and spoken French
* with non-resectable metastatic cancer of: the colon, or the rectosigmoid junction or the stomach or bile ducts or rectum or gastrointestinal neuroendocrine tumor or lung (not small-cell cancer) or pancreas
* with a caregiver designated as the principal caregiver (family, friend, neighbour)
* who has consented to the principal caregiver taking part in a qualitative interview
* able to take part in an interview lasting roughly one hour

II- CAREGIVERS

* men or women
* who have been informed about the study
* who have provided verbal consent to take part in the study
* able to understand written and spoken French
* able to follow an interview lasting roughly one hour

III-DOCTORS

* men or women
* who have been informed about the study
* who have provided verbal consent to take part in the study
* specialised in specific organ or oncologist prescriber

Exclusion Criteria:

I- PATIENTS

* under guardianship or ward of court
* with a severe handicap (neurological disease: Parkinson, Alzheimer, other dementia, multiple sclerosis, severe mental retardation etc.)

II- CAREGIVERS

* under guardianship or ward of court,
* with a severe handicap (neurological disease: Parkinson, Alzheimer, other dementia, multiple sclerosis...),
* with severe mental retardation impairing ability to understand.
Parallel Study Between BMP-2 and Autologous Bone Graft After Ilizarow Treatment

Results of growth factors indicate that Bone Morphogenetic Proteins (BMP) have an exceptional ability to stimulate different characteristics of mesenchymale cells to osseous cells. Local application of BMP results in an increase of osseous tissue regardless of the location of the growth factor.

5 years clinical studies show that BMP's can stimulate an increase of osseous tissue and improve clinical results when autologous bone graft is reduced or removed.

The purpose of this study is to examine whether recombinant growth factor BMP-2 can replace autologous bone graft in order to stimulating ossification during transplantation of osseous tissue.


Eligibility Criteria:
Inclusion Criteria:

* Hospitalised for autologous bone graft based on Ilizarow treatment.
* Age between 20 and 70 years.

Exclusion Criteria:

* Rheumatoid osteoarthritis
* Malignant disease
* Current hormone treatment (glucocorticoid, parathyreoidea, thyreoidea)
* Pregnancy
* Abuse of drugs and alcohol
* Need of long-term NSAID treatment
* Breastfeeding women
Trial on Treatment With Inhaled Furosemide of Preterm and Term Neonates With Transient Tachypnoea

In this study we will prospectively analyze the benefit of inhaled furosemide for preterm and term neonates with Transient Tachypnoea.

In this study we will prospectively analyze the benefit of inhaled furosemide for preterm and term neonates with transient Tachypnoea. Patients received nebulised Furosemide iv solution 1 mg/kg or nebulised 0,9% saline (4x/d) under blind conditions in random order so long as need a CPAP-treatment but max. 3 days. 20 Patient will be treating.

The benefit will be measured as reduction of dyspnea, respiratory rate, oxygen demand and time on CPAP.

Eligibility Criteria:
Inclusion Criteria:

* Neonates with 35+0-39+0 GA on the first day of life with the clinical diagnosis of Transient Tachypnoea
* The need for CPAP \>6 h to obtain the oxygen saturation \>92%
* Written informed consent of parent/guardian

Exclusion Criteria:

* Systemic infection
* Intubation and mechanical ventilation before Inclusion in the trail
* Malformation and any other several disease with disturb of respiratory
* Subjects participating in other clinical trials
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)

An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

This interventional, non-pharmacological, monocentric study examines the effectiveness of cognitive rehabilitation in counteracting CRCI in women with operable breast cancer treated with neo-adjuvant therapy and/ or adjuvant therapy.

A total of 128 patients will be randomized 1:1 into two groups:

* Experimental group, which will participate in a cognitive rehabilitation program using Neurotablet® and paper and pencil exercises. To evaluate the efficacy of the cognitive rehabilitation program, neurocognitive evaluations will be performed.
* Control group, which will only carry out neuropsychological assessments.

Neuropsychological evaluations will be conducted before the start of chemotherapy (T0), 6 months (T1) and 12 months (T2) after the start of chemotherapy. Neuropsychological evaluations will include tests to analyze the main cognitive domains of memory, attention, executive functions and learning.

Eligibility Criteria:
Inclusion Criteria:

* Signature of informed consent
* Diagnosis of operable/operated breast cancer
* Patients candidate to be treated with Neo/adjuvant chemotherapy

Exclusion Criteria:

* Previous chemotherapy treatments
* Patients with Metastatic breast cancer
* Patients affected by pathologies of the brain, head trauma, and intellectual disabilities
* Patients affected by previous or current neurological and/or psychiatric disorders
* Patients currently treated with psychopharmacological drug
Influence of BIIAL Following PPH on Dorsal Clitoral Artery Blood Flow and FSFI

Dorsal clitoral artery Doppler examinations in women with bilateral internal iliac artery ligation due to postpartum hemorrhage (study group) and age-matched healthy puerperal women were performed regularly in the postoperative period, in order to evaluate possible effects of BIIAL on clitoral blood flow.

Women who underwent bilateral internal iliac artery ligation due to postpartum hemorrhage in Gaziantep Cengiz Gokcek Maternity Hospital, Gaziantep Turkey and Near East University, Department of Obstetrics and Gynecology, Mersin, Turkey comprise the study group. The control group consists of age-matched healthy women who delivered in last 2 months.

Dorsal clitoral artery Doppler examinations will be performed in both case and control groups regularly in the postoperative period in 3rd and 6th months, in order to evaluate the possible effects of BIIAL on clitoral blood flow. Ultrasound is performed using a Mindray DC-7 Ultrasound System (China) equipped with linear 7.5 MHz probe. Each woman was scanned in the gynecological position. The translabial probe is placed on the clitoris sagittally and transversely without applying any pressure force. After identifying the clitoral artery using colour flow mapping, the Doppler probe is positioned over the vessel and at least three sequential Doppler wave forms are obtained. The following parameters are analysed: peak systolic velocity (PSV), end diastolic velocity (EDV), resistive index (RI), pulsatile index (PI) and systolic/diastolic (S/D) ratio. The measurements are performed by the same radiologist.

Finally a Female Sexual Fantasy Questionnaire (FSFQ) is performed.

Eligibility Criteria:
Inclusion Criteria:

* 18-35 year-old women who underwent bilateral internal iliac artery ligation (BIIAL) due to postpartum hemorrhage
* Age-matched healthy puerperal women

Exclusion Criteria:

* Known Diabetes Melitus or cardiovascular disease
* Known affection disorder before or during pregnancy
* B-lynch procedure, ligation of uterine or ovarian artery, hysterectomy and salphingooophorectomy following postpartum hemorrhage
* Known functional sexual disorder before pregnancy
* Postoperative endometritis or other puerperal infections
* Postoperative thromboembolic incidence
* Cessation of breastfeeding in puerperal period
FMRI in Monitoring Intracerebral Stem Cell Implantation for Chronic Stroke Patients

A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke in animal model. But the stem cell therapy for chronic stroke patients has not been well investigated yet. In this study, the investigators will test the hypothesis that intracerebral peripheral blood hematopoietic stem cell (CD34+) (PBSC) transplantation induces neuroplasticity in chronic stroke patients. The remyelination of corticospinal tract in the lesion side, focal increased perfusion and increased cortical activity in the peri-infarcted area will be monitored by the functional MRI after stem cell therapy. The investigators study is aimed to find the potential mechanisms of the functional recovery after stem cell implantation. The investigators also hope to find image surrogate markers for prediction of patient outcome. The possible surrogate markers will be helpful in improving the treatment procedure and patient selection.


Eligibility Criteria:
Inclusion Criteria:

* Old stroke half an year \~3 year
* One-sided MCA infarction
* NIHSS stroke scale: 9-20

Exclusion Criteria:

* Pacemaker
* Cerebral aneurysm clips
* Neurostimulator
* Metallic heart valves
* IUD
* Joint replacement
* Metal plates
* Bone or joint pins
* Vena cava filters
* Embolization coils
* Cochlear implants
* Greenfieid filer
* Seizures
* Claustrophobia
* Bullet/gunshot
* Prosthesis (non-removeable)
* Artificial limbs (non-removeable)
* Surgical slips
* Metal screws or pins\>
* Shrapnel/metallic fragments
* Harrington rod
* Insulin pump
* Ever had metal removed from in or around the eye
* Ever been metal worker (i.e., welder, machinist)
* Non-removeable hearing aids
* Birdnest or Gianturco filter
* Pregnant
EPiMAP Obstetrics: European Practices in the Management of Accidental Dural Puncture in Obstetrics

The aims of EPiMAP Obstetrics are:

* to identify risk factors for failure of epidural blood patch in the obstetric population for management of post dural puncture headache.
* to describe European practices in the management of accidental dural puncture in the Obstetric population.

The primary aim of this prospective, international audit of practice is to identify risk factors for failure of epidural blood patch (EBP) in the Obstetric population after accidental dural puncture (ADP) with an epidural needle. Other aims are to describe the epidemiology, management principles, side effects and complications of ADP and longer-term effects of ADP on patients undergoing Obstetric anaesthesia and analgesia. Expectation is that this audit of practice will provide important information in understanding the reasons for failure of EBP and subsequently to better manage parturients affected by this debilitating complication.

Postdural puncture headache (PDPH) is the most common serious complication of accidental dural puncture (ADP), and feared by every Anaesthesiologist. It is associated with significant peri-partum maternal distress, and poor bonding with the baby, which in turn leads to physical disability for the mother and psychological and social implications for the whole family. It is estimated that about 10,000 parturients in Europe may have an accidental dural puncture (ADP) each year. Attitudes and practices in the management of ADP are based on small studies, and sometimes driven by experience rather than evidence. Although several methods have been described in the literature to treat PDPH, one common method used is an epidural blood patch (EBP). This is believed to be successful in about 60-80% of parturients on the first attempt, but results from most studies are based on a small numbers of patients. The reasons and predisposing factors for success and failure of different management strategies, specifically EBP, therefore needs to be investigated and described. Large observational studies on post-dural puncture headache in the Obstetric population are singularly absent from the literature.

Eligibility Criteria:
Inclusion Criteria:

* All women ≥ 18 years old, who develop classical symptoms of post-dural puncture headache after epidural anaesthesia for labour or for caesarean section.

Exclusion Criteria:

* Post-dural puncture headache following deliberate dural puncture with a spinal needle in women where there was no observed accidental dural puncture with an epidural needle.
Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled Trial

The aim of this study is to test the hypothesis that addition of dexmedetomidine to fentanyl-based intravenous patient controlled analgesia (PCA) reduces requirement of fentanyl bolus and consequent postoperative nausea and vomiting in high-risk patients undergoing lumbar spine surgery.


Eligibility Criteria:
Inclusion Criteria:

1. female, non-smoking patient who are 20-65 of age scheduled for elective lumbar spine surgery

Exclusion Criteria:

1. Bradycardia on EKG (45bpm)
2. Atrioventricular conduction disorder
3. Uncontrolled hypertension
4. angina history
5. obesity (BMI ≥ 30 kg/m2)
6. Preoperative administration of opioid
7. Preoperative administration of antiemetics
8. Gastrointestinal disorder history
9. Hepatic or renal disease
10. Pregnant 11. Foreigner