cyrilzakka/clinical-trials huggingface dataset:
Performance Comparison of QuantiFERON Monitor in Solid Organ Transplant Recipients

To compare the performance of the QuantiFERON Monitor assay against existing methodology.


Eligibility Criteria:
Solid Organ Transplant Recipient

Inclusion Criteria:

* Provide Informed Consent
* Received a solid organ transplant

Exclusion Criteria:

* Pregnancy or recent lactation (\<1yr)
* Treatment of Rejection

Healthy Control

Inclusion Criteria:

* Provide Informed Consent

Exclusion Criteria:

* Currently taking any immunomodulatory medication
* A history of immunosuppressive disease or immunosuppression condition or history of autoimmune diseases
* Current pregnancy or recent lactation (\<1yr)
* Currently taking antiviral medication
* Currently being treated for infectious diseases
The Effect of Kinesthetic Motor Imagery Training and Dual Task Training on Cognitive and Motor Functions in Healthy Youth

The goal of this clinical trial is to investigate the effects of kinesthetic motor imagery training and dual-task training on cognitive and motor functions in healthy young people. The main question\[s\] it aims to answer are:

* Kinesthetic motor imagery training and dual-task training do not affect cognitive and motor functions in healthy young people.
* Kinesthetic motor imagery training and dual-task training affect cognitive and motor functions in healthy youth.
* In healthy young people, kinesthetic motor imagery training is more effective on cognitive functions than dual-task training.
* In healthy young people, dual task training is more effective on motor functions than kinesthetic motor imagery training.

Participants will be divided into 3 groups, taking into account the inclusion and exclusion criteria. Participants in each group will be asked to fill out the sociodemographic form before starting the training. Then, initial assessments were the Motion Image Questionnaire-3 to measure motor imagery ability, and the Box and Block Test for mental stopwatch; Stroop Test to measure cognitive functions; In order to evaluate the dual-task performance, the measurement of the dual-task effect and the Berg Balance scale, which evaluates balance as a motor function, and the Y test, which is frequently used in healthy individuals, will be applied. In the balance exercises group, the participants will do the determined balance exercises 3 days a week for 6 weeks, accompanied by a physiotherapist. In the double-task training group, the participants will perform the cognitive tasks in addition to the determined balance exercises, 3 days a week for 6 weeks, accompanied by a physiotherapist. In kinesthetic motor imagery group, the participants will do the physically determined balance exercises in the first session. Participants will participate in imagery exercises, 3 sessions a week for 6 weeks. Visualization studies will be performed in a quiet environment with the eyes closed, accompanied by a physiotherapist, and whether the participants perform a real motor imagery will be examined by evaluating their autonomic functions. At the end of 6 weeks, initial evaluations will be repeated in all groups.

The investigators will compare dual-task training group, kinesthetic motor imagery training group and balance exercises group to see if changes in cognitive and motor function.


Eligibility Criteria:
Inclusion Criteria:

* be between the ages of 18 and 25,
* Absence of a known disease (neurological, mental, orthopedic, vestibular, visual, systemic),
* Unfamiliar with the evaluation and use of motor imagery,
* Individuals who agree to the objectives of this study and to participate voluntarily.

Exclusion Criteria:

* Those who have taken oral corticosteroids or antibiotics within a month,
* Presence of diagnosed systemic or neurological disease.
Oscillation and Lung Expansion Therapy in Patients With COVID-19

A Pilot Study of the Use of Oscillation and Lung Expansion (OLE) Therapy in Patients Hospitalized with COVID-19

This is a randomized prospective open-label cohort study in patients with COVID-19 to evaluate the impact of Oscillation and Lung Expansion (OLE) therapy using The MetaNeb® System on the hospital length of stay in patients hospitalized and receiving heated high-flow oxygen therapy for COVID-19 infection. The active treatment group will consist of patients who are treated OLE therapy while on heated high-flow oxygen therapy .

Results from subjects in the active treatment group will be compared to results from patients treated with standard care with no OLE therapy.

Eligibility Criteria:
Inclusion Criteria:

* Adult patient (\> 18 years of age)
* Tested positive or person under investigation (PUI) for COVID-19 infection
* Currently require heated high-flow oxygen therapy to maintain SaO2 \> 90 %
* Signed informed consent (phone consent)
* Heated high-flow oxygen initiated within the past 72 hours

Exclusion Criteria:

* Serious medical condition that, in the investigator's judgment, precludes the patient's safe participation in the study
* Pressure related risk for pneumothorax
* Patient inability or unwillingness to tolerate OLE therapy
* Staff unavailable or unable to deliver therapy
* Current requirement for mechanical ventilation or expected requirement for mechanical ventilation within the next 12 hours
Establishing Technique for PECS2 Catheter Insertion

The investigators are trying to establish an easy technique for insertion of a catheter for continuous infusion while performing pectoral type 2 (serratus) block, as a post operative pain controlling measure for cases undergoing simple mastectomy, using ultrasound guidence

As the space between the pectoralis minor and the serratus anterior is a fashial plane with a connective tissue occupying. we are trying to demonstrate a simple technique for inserting a catheter within that fashial plane and making sure of the catheter position, to ensure post operative analgesia for cases performing simple mastectomy.

Now the Pectoralis type 2 block (PECS type 2) is an established technique as regional block technique for chest wall procedures.

We are trying to maximizing the benefit of the block with a catheter insertion to use it for continuous infusion of bupivacaine for controlling post operative pain in cases performing simple mastectomy procedure

Eligibility Criteria:
Inclusion Criteria:

* Female patient scheduled for simple mastectomy
* Accepted performing the block

Exclusion Criteria:

* Patients on anticogulants
* Chest wall infection
* Patient refusal
The Anterior Approach of the Combined Lumbar and Sacral Plexuses Block for Analgesia of Lower Limb Surgeries

lumbosacral plexus block (LSPB) has been widely applied in orthopedics departments due to its advantages, including reduction in the application of opiates, decreasing the occurrence of acute pain, promoting early activation, and shortening the time of hospital stay. LSPB is a peripheral regional technique of anesthesia and analgesia, that provides a block of the main components of the lumbosacral plexus.

Traditional ultrasound-guided lumbar plexus block combined with sacral plexus block requires separate blocks at different sites, requiring the lateral decubitus or prone position, which may be suboptimal in patients with severe pain. we present an anterior approach for combined lumbar and sacral plexus blocks with a one-point puncture.

Eligibility Criteria:
Inclusion Criteria:

* ASA I-II.
* patients scheduled for unilateral femur or tibial surgery necessitate knee joint intervention
* patients who have severe pain hindering changing their position or patients who have spinal fractures or refusing spinal anesthesia.
* patients with the capability of communication

Exclusion Criteria:

* puncture site infection
* patients with coagulation disorders
* patients who refuse to participate or withdraw due to personal reasons
* allergy to local anesthetics.
* past surgery at the site of the block
* hip ankylosis
* drug abuse
* Body mass index ≥ 35 kg/m2
* peripheral vascular insufficiency
* use of alpha or beta blocker agents
* Nerve injury or neuropathy of the affected lower limb
* cardiovascular or respiratory decompansation
Evaluation of Airtraq in Pediatric

This study indented to evaluate the use of Optical laryngoscope in pediatric

The authors are welling to study how intubation will differ if Airtraq optical laryngoscope used in pediatrics

Eligibility Criteria:
Inclusion Criteria:

* Healthy children undergoing general anesthesia required tracheal intubation.

Exclusion Criteria:

* History of difficult intubation.
* Risk of aspiration.
* Children with cardiovascular disease.
* Children with respiratory disease.
Urology Database for Outcomes Research

The purpose of initiating the urology database is to collect relevant retrospective data via chart review related to patients undergoing radical prostatectomy via the retropubic, perineal, laparoscopic, and robotic assisted laparoscopic approaches and InterStim implantation. This data will be utilized to evaluate the health benefits and outcomes of each of these procedures to enhance care and treatment.

The objective of this study is to initiate and maintain a patient information database that will be used to study the impact of each surgical procedure on patients' overall health, quality of life, and bowel/bladder/sexual function.

The study coordinator will, on an ongoing basis, abstract needed medical information from inpatient hospital and physician office records for inclusion into the database.

Eligibility Criteria:
Inclusion Criteria:

* All patients undergoing radical prostatectomy or InterStim implantation at William Beaumont Hospital.

Exclusion Criteria:

* None
Breathing Versus Aerobic Exercises on Asthma Control

Background: Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to benefit asthmatic patients; however, there is no evidence comparing the effectiveness of the treatments. Objective: To compare the effects of aerobic and breathing exercises on clinical control (primary outcome), psychosocial morbidity and daily life physical activity (secondary outcome) in patients with moderate-to-severe persistent asthma. In addition, thoracoabdominal kinematics, heart rate variability and airway and systemic inflammation will be evaluated. The initial hypothesis will be that both exercises present improved clinical control of asthma. Methods: Forty-eight asthmatic adults will be randomly divided into 2 groups: aerobic (AG) and breathing exercises (BG). All treatments will be performed twice a week for 3 months, totalizing 24 sessions of 40 minutes each. Both groups will complete an educational program consisting of 2 classes at the beginning of the interventions. Before and after interventions, the following parameters will be quantified: clinical control, health related quality of life, levels of anxiety and depression, maximal exercise capacity, autonomic nervous imbalance, daily living physical activity, thoracoabdominal kinematics, inflammatory cells in the sputum, fraction of exhaled nitric oxide (FENO) and systemic inflammatory cytokines. Asthma symptoms will be quantified monthly using diaries. Kolmogorov-Smirnov test will be used to analyze the data normality, and a two-way ANOVA with repeated measures with appropriate post hoc test (Student Newman Keuls) will be used to compare the inter and intra-groups differences

Both groups completed an educational program that consisted of two classes held once a week, each lasting 2 hours. Presentations and group discussions were done, including information about asthma pathophysiology, medication skills, self-monitoring techniques, and environmental control and avoidance strategies.

Eligibility Criteria:
Inclusion Criteria:

* Asthma moderate and severe
* Asthma will diagnosed (Global Initiative for Asthma -GINA)
* Body Mass Index \<35 kg/ m2
* Sedentary
* Medical treatment, for at least 6 months
* Clinically stable

Exclusion Criteria:

* Smokers
* Cardiac disease
* Chronic Obstructive Pulmonary Disease
* Active Cancer
* Pregnant
Mental Health Content and Mental Health Outcomes

The study will aim to explore the relationship between mental health content on social media and health behavior, addressing a gap in empirical research. Using the Theory of Planned Behavior, a survey with over 600 participants will examine associations between exposure to mental health content and behaviors like help-seeking and self-diagnosis.

Background: Mental health content has recently surged in popularity across social media. However, current empirical research lacks a comprehensive understanding of the relationship between mental health content and health behaviour.

Objective: This study will aim to address this gap by examining different types of mental health content and their relationship to behavior. Specifically, it will explore whether exposure to mental health content will be associated with either positive behaviors, like help-seeking, or maladaptive ones, such as self-diagnosing.

Methods: Utilizing the Theory of Planned Behavior, a cross-sectional epidemiological survey will be conducted with over 600 participants to answer the research questions. Baseline measures will include participants' exposure to various types of mental health content, and mental well-being (depression, anxiety, and scores from the DASS-21). The outcome measures of interest will be help-seeking attitude (IASMHS) and self-diagnosing (SELF-I) behavior.

Eligibility Criteria:
Inclusion Criteria:

* Enrollment is restricted to healthy adults between 21-34 (or 18-34 for university students)
* Use at least one social media platform (e.g., Facebook, Instagram, LinkedIn, X)
* Participants need to be able to read and understand English.
* Participants must also have lived in Singapore for at least 2 years.

Exclusion Criteria:

* Anyone who does not feel comfortable answering questions related to mental health and exposure to mental health-related content online.
Prevention of AcuTe admIssioN Algorithm (PATINA)

Utilization of public health care mirrors the older individual's overall health, and increased need for health care may precede more clear symptoms of acute disease. In a previous retrospective study, we found a significant increase in municipal home care service (minutes/week) in a 12-month period prior to acute hospitalization. This PhD-study aims at examining the effect of a software algorithm monitoring older citizens utilization of municipal home care. When home care increases the community nurse is notified and special attention is paid to the individual's current health situation. Pro-active health care initiatives may be launched in collaboration with the primary care physician. The intervention is the algorithm.


Eligibility Criteria:
Inclusion Criteria:

* Community dwelling citizens (+ 65) receiving home and social care in Odense, Kerteminde and Svendborg Municipalities.

Exclusion Criteria:

* Non
Lubiprostone in Patients With Multiple Sclerosis Associated Constipation

The purpose of the study is to assess how safe and effective the drug Lubiprostone is in people with Multiple Sclerosis (MS)and moderate to severe MS-associated constipation. Lubiprostone is approved by the FDA for the treatment of two common types of constipation in adults, chronic idiopathic constipation and irritable bowel syndrome.

Multiple Sclerosis (MS) is a disorder of the body's immune system that affects the central nervous system. Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the bowel. In people with MS, the covering around the nerve fibers deteriorates, causing nerve impulses to be slowed or stopped. as a result, patients with MS may experiences constipation.

Eligibility Criteria:
Inclusion Criteria:

* Multiple Sclerosis
* Chronic Constipation defined as \< 3 spontaneous bowel movements per week by history and confirmed by diary during the 14 day washout period.
* Women of child-bearing potential must agree to use adequate birth control.

Exclusion Criteria:

* history of other clinically significant medical or psychiatric disorders or suicidal ideation.
* Subjects who have a suspicion of a mechanical bowel obstruction by clinical evaluation prior to dosing that include nausea, vomiting, abdominal pain or distention.
* Subjects with a positive urine pregnancy test prior to dosing.
* Medication changes within one month prior to visit one.
* Corticosteroid use within 2 months prior to visit one.
* Age\<18.
* Known intolerance to lubiprostone.
* Inability to perform any required study procedures.
A Pilot Study for the Efficacy and Safety of Tacrolimus in the Treatment of Refractory Lupus Nephritis

The purpose of this protocol is to determine whether Tacrolimus and Prednisolone are effective and safe in the treatment of the cyclophosphamide-resistant, refractory diffuse proliferative lupus nephritis


Eligibility Criteria:
Inclusion Criteria:

* Biopsy-proven lupus nephritis WHO Class IV , IV+V
* Previously treated by three times over of i.v. cyclophosphamide or 6 months more duration of immunosuppressive treatments (azathioprine, MMF, cyclophosphamide p.o.) for the lupus nephritis
* spot urine Protein creatinine raio \> 1.0
* RBC \> 5 /HPF on microscopic examination of urine

Exclusion Criteria:

* previous treatment of cyclosporine A or tacrolimus
* serum Creatinine lever : over 300 mmol/dl
* allergy to the macrolide antibiotics
* other systemic organ damage
Perioperative Immunonutrition for Patients Undergoing CRS and HIPEC

Patients with peritoneal disease commonly present with symptoms of abdominal distension and subacute intestinal obstruction. This results in poor oral intake leading to these patients often presenting in a malnourished state.

CRS and HIPEC can potential provide improve survival for these patients, however can be a hazardous procedure, involving multi-organ resections. The risk is especially high in poorly nourished patients.

The study investigators hypothesize that perioperative immunonutrition can reduce wound infections and length of hospital stay, and improve perioperative outcomes. To the investigators' knowledge, it has not been evaluated in patients undergoing CRS and HIPEC.


Eligibility Criteria:
Inclusion Criteria:

1. All patients planned for CRS and HIPEC, with sufficient time (5 to 7 days) prior to surgery for start of nutritional supplements are eligible
2. All patients must be able to provide informed consent
3. There are no restrictions to use of contraception

Exclusion Criteria:

1. Patients who are not able to provide informed consent will be excluded.
2. Patients with a diagnosis of diabetes mellitus will be excluded.
3. Patients not fit for surgery or those who undergo surgery under emergency situations will be excluded.
4. Patients who have intestinal obstruction and not able to consume the nutritional supplements orally will be excluded.
AntiCoagulation Tracking InterVention and Evaluation

Anticoagulants are a leading cause of acute injury from adverse drug events, leading to \~20,000 serious injuries reported to the Food and Drug Administration per year and more than 220,000 emergency department visits annually. Therefore, we propose to implement a health information technology (HIT) population management tool at two distinct anticoagulation clinics that will allow the care team to assign and track tasks essential for timely patient monitoring. We will examine its effect on anticoagulation management outcomes through a randomized trial, hypothesizing that such interventions can be effective as well as cost-effective strategies to improve patient safety in the context of anticoagulation management services.


Eligibility Criteria:
Inclusion Criteria:

* Adults (age ≥18 years)
* those prescribed an anticoagulation medication at Zuckerberg San Francisco General Hospital or University of California, San Francisco Health

Exclusion Criteria:

* Minors (age\<18)
* those not prescribed anticoagulation medication at ZSFG or UCSF Health
Assessment Of Different Scores In Predicting Outcome In AECOPD Patients In Emergency Department

evaluate the value of different scores in predicting hospital mortality and Need for MV In patients presented to ED with AECOPD.

Chronic obstructive pulmonary disease (COPD) is one of the top three causes of death worldwide, and 90% of deaths occur in low- and middle-income countries.

Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is defined as an acute change in patient's dyspnea, cough, or sputum beyond normal variability that is sufficient to warrant a change in therapy. AECOPD has a negative effect on the quality of life, admission and readmission rates, and disease progression.

For these reasons, appropriate management of acute exacerbations is recommended by national and international organizations.

Identifying high-risk dying patients on hospital admission helps in triaging them to the required level of care.

The use of early warning scores in follow-up is recommended for the early detection of critically ill patients and the prediction of clinical deterioration. CURB65, BAP65, qSOFA , DECAF and NEWS, which mainly involve mental status, respiratory rate, oxygen saturations, pulse, blood pressure, age, BUN level, etc., can be used to predict AECOPD-associated mortality in ED given the simple structure and data availability.

Eligibility Criteria:
Inclusion Criteria:

* All patient presented to ED with acute exacerbation of COPD.

Exclusion Criteria:

* Patient presented with acute insult affecting other system.
* Patient transferred to other centers.
* Inadequate data.