cyrilzakka/clinical-trials huggingface dataset:
Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

The purpose of the study is to investigate effect of medical treatment and prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

Many patients who complained of dizziness are eventually diagnosed as POTS. However, the investigation of an appropriate medical treatment of POTS has not been enough yet. Also, the prognosis of the disease after treatment is not well known. It is known that propranolol attenuate the tachycardia and improve symptom burden in patients with POTS. However, the effect of other β-Blocker, bisoprolol compared with propranolol is not known well. In addition, acetylcholinesterase inhibition with pyridostigmine was a effective method of acutely decreasing the tachycardia in patients with POTS. However, difference among three medical treatments effect is not known and long-term studies are not done yet. Therefore, in this study investigator investigate effect of medical treatment (propranolol only, bisoprolol only, propranolol+pyridostigmine, bisoprolol+pyridostigmine) and prognosis of Postural Orthostatic Tachycardia Syndrome.

Longer-term studies are needed to assess this promising therapy.

Eligibility Criteria:
Inclusion Criteria:

* aged 15\<=
* developed symptoms of orthostatic intolerance accompanied by a HR rise ≥30 min-1 within the first 10 minutes of standing, HR rise ≥ 120 in the absence of orthostatic hypotension (a fall in blood pressure \[BP\] \>20/10 mm Hg).

Exclusion Criteria:

* poor drug compliance
* patients who cannot or do not want to write questionaires.
* patients who do not want draw blood
An Evaluation the Effect of Superhydration Versus Dextrose 10% for Prevention of Post Operative Nausea and Vomiting After Laparoscopic Cholecystectomy (prospective Randomised Controlled Study)

The goal of this clinical trial is to learn if Dextrose 10% or superhydration works to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

. The main questions it aims to answer are:

Does Dextrose 10% or superhydration lower the number of times participants gets an episode of nausea and vomititng after laparoscopic cholecystectomy surgery? Researchers will compare Dextrose 10% versus superhydration to a placebo (a look-alike substance that contains no drug) to see if glucose 10% or superhydation can work to prevent postoperative nausea and vomiting.

Participants will:

Take Dextrose 10% or superhydration or a placebo in the operation monitored for 4 hours after surgery to check on their nausea and vomiting state


Eligibility Criteria:
Inclusion Criteria:

1. Age: 21- 60 years
2. Patients with ASA classification I and II

Exclusion Criteria:

1. Declining to give written informed consent.
2. Patients with morbid obesity (BMI \> 40).
3. ASA classification III-V.
4. Sever hypertension and heart failure.
5. Significant hepatic or renal disorder.
6. Patients with diagnosed diabetes mellitus type 1 or type 2.
7. Patients with history of PONV currently receiving steroids or antiemetics.
8. Pregnant or menstruating patients.
A Phase III Trial to Assess the Efficacy, Acceptability and Safety of Moviprep® Versus a 4L PEG+E Standard Solution

The study was carried out as a randomised, single-blind, active-controlled, multi-centric, phase III study with two parallel treatment groups. The primary efficacy criterion was the frequency of effective gut cleansing in each of the two treatment groups (grade A or B "overall quality of gut cleansing" as judged by a blinded expert panel on the basis of videotapes recorded during the endoscopic procedure).

The study was designed as a randomised, active-controlled, single-blind, multi-centre, pivotal phase III trial with two parallel treatment groups. 15 German hospitals with specialised gastroenterology units were expected to participate in the investigation.

Up to 360 hospital in-patients routinely scheduled to undergo complete colonoscopy were to be enrolled one to two days prior to the endoscopic procedure, and to be randomly allocated to one of the two treatment arms in a ratio of 1:1. Bowel preparation was performed using equal split doses of either low-volume NRL994 (two doses of 1,000 mL each) or high-volume PEG+E (two doses of 2,000 mL each). The first dose was to be taken in the evening before the procedure, the second dose on the morning of the day of the colonoscopy. The patients allocated to NRL994 were asked to drink at least 1L of additional clear liquid in addition to the study drug. During colonoscopy the cleansing of each of the five pre-defined gut segments was to be assessed by the physician performing the examination, using a 5-level verbal rating scale. Videotapes were to be recorded of all procedures in order to allow central review by a blinded and independent expert panel whose ratings were the primary basis for the analysis of efficacy. The patients enrolled in the study were asked to fill in a questionnaire concerning the acceptability of the preparation. A patient's participation in the study was terminated upon completion of the intervention by performing a final examination and filling in the study termination page. No interim analysis was to be performed.

Eligibility Criteria:
Inclusion Criteria:

* written informed consent prior to inclusion;
* male or female in-patients, aged 18 to 85 years, with indication for complete colonoscopy;
* willing and able to complete the entire procedure and to comply with study instructions;
* females of childbearing potential employing an adequate method of contraception.

Exclusion Criteria:

* ileus;
* intestinal obstruction or perforation;
* toxic megacolon;
* congestive heart failure (NYHA class III and IV);
* acute life-threatening cardiovascular disease;
* untreated or uncontrolled arterial hypertension (SBP max\>170mmHg, DBP min\>100mmHg);
* severe renal failure;
* severe liver failure;
* known glucose-6-phosphatase dehydrogenase deficiency;
Strategies of Therapy With the Exoskeleton Robot ARMin

Neurological patients (e.g., after stroke) need long-term neurorehabilitation therapy of the arm with often limited, unsatisfactory outcome. Robots became a promising supplement or even alternative for neurorehabilitation training.

The exoskeleton robot ARMin was further developed and software components adapted accordingly to offer a unique intensified and patient-tailored robot-aided training of the arm. The goal is to enhance treatment efficacy to an extent that the improvement in motor function is meaningful for the individual patient. The study objective is to compare ARMin therapy and a form of conventional occupational therapy that involves both arms regarding change in motor function.

Eligibility Criteria:
Inclusion Criteria:

* - Aged ≥18 years
* Ischemic cerebral vascular accident (CVA, stroke) in the sub-acute phase (one to twelve weeks post-stroke) as verified by brain imaging (CT or MRI)
* Inpatient at Rehaklinik Zihlschlacht, Switzerland
* Decreased arm motor function in one arm with a FMA of 8 to 20 points (out of 66)
* No excessive spasticity of the affected arm (modified Ashworth Scale mAS ≤3) as assessed by the physician
* No serious medical or psychiatric disorder as assessed by the physician
* No serious orthopaedic, rheumatologic or other disease restricting movements of the paretic arm as assessed by the physician
* No clinically significant shoulder subluxation (palpation \<2 fingers) as assessed by the physician
* No skin ulcerations at the paretic arm as assessed by the physician
* Ability to communicate effectively with the examiner such that the validity of the patient's data could not be compromised as assessed by the physician
* No history of cyber sickness (e.g., nausea when looking at a screen or playing computer games) as assessed by the physician
* No pacemaker or other implanted electric device as verified by patient record
* Bodyweight \<120 kg
* No serious cognitive defects or aphasia preventing effective use of ARMin as assessed by the physician
The Factors Associated With the Recurrence in Patients With Cushing Disease

Cushing syndrome refers the manifestations induced by chronic glucocorticoid excess and may arise from various causes. Iatrogenic Cushing syndrome accounts for most patients, when they are given exogenous glucocorticoid treatment. In contrast, spontaneous Cushing syndrome results from endogenous glucocorticoid over-secretion. Although Cushing disease is rare, it is the most common cause of spontaneous Cushing syndrome. The patient with Cushing disease has a pituitary corticotroph adenoma, which overproduces adrenocorticotropic hormone (ACTH). ACTH then stimulates adrenal gland to over-secret glucocorticoid. Patients with untreated Cushing disease were shown to have poor prognosis, estimated a 5-year survival rate of 50%. The first line treatment is tumor resection. Other managements include radiotherapy, medication and bilateral adrenalectomy. The initial remission rate is high (66-90%). However, some patients encounter with disease recurrence during follow-up.

The aim of this study is to clarify the factors associated with the recurrence after treatment. In this study, we will review the patients with Cushing disease thoroughly and analyze associated predisposing factors. These risk factors can remind the clinical physician to early detect the recurrent disease in these patients, and further prevent morbidity and mortality in their later lives.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosed Cushing's disease

Exclusion Criteria:

* Already received treatment in other hospital
* Ectopic Cushing's syndrome
Comparison of the Effects of Carboxytherapy and Radiofrequency on Skin Rejuvenation

Carboxytherapy (CA) refers to the cutaneous and subcutaneous administration of carbon dioxide gas \[CO2\] for therapeutic purposes. Radiofrequency (RF) is a method that uses electric current to generate heat into the layers of the skin and the subcutaneous tissue. Both techniques are indicated to the treatment of skin laxity. The aim of this study was to compare the effects of CA an RF on human skin. Methods: Eight patients who underwent abdominoplasty surgery received a single procedure of both treatments. Untreated skin was used as control. In an area of 49 cm2 (7 x 7 cm) in the infra-umbilical region CA was performed on the right and RF on the left side. Sample collection period ranged from zero to 120 days. CA was administered at a velocity of 40 ml/min, and the total quantity of CO2 infused was approximately 20ml. RF was carried out in a temperature higher than 40ºC on the epidermis for 5 minutes after reaching this temperature.

Untreated skin was used as control. In an area of 49 cm2 (7 x 7 cm) in the infra-umbilical region CA was performed on the right side and RF on the left side. CA was administered using the beveled end of a 30G ½ needle introduced in the skin in an angle of approximately 30ºC and delivered at a velocity of 40 mL/min. The total quantity of CO2 infused was approximately 20 mL (0,3 to 0,6 mL/kg of patient's body weight) encompassing the whole delimited are. For the RF treatment, the epidermal temperature was controlled using an infrared thermometer monitored to reach 40ºC and treatment time was of five minutes starting after having reached this temperature. Sample collection varied from zero to 120 days after application. The samples were then fixed, cut in paraffin (5 µm) and stained with Picro sirus and Weigert. Morphological analyses were acquired using a Zeiss Axiophot® microscope, and they were processed using Adobe Photoshop®.

Eligibility Criteria:
Inclusion Criteria:

* Patients who underwent abdominoplasty surgery and agree to participate to this study

Exclusion Criteria:

* patients been treated with corticosteroids or anti-inflammatory during the period of the protocol, with cancer or other change that contraindicated the application of carboxytherapy and radiofrequency
Fall Prevention Among Community Living Elderly

The purpose of this study is to assess effects of a home exercise program, supervised by assistant nurses with the aim of preventing falls.

Community living persons 65 years of age or older having a risk of falling were invited to participate. Participants were randomized to either training or control.

The training program was individually designed by a physiotherapist and the 5-month program performance was supervised in the partcipants home by eight home visits from an assistant nurse.

All participants received a visit from an occupational therapist who assessed the home and, if necessary, gave advice.

Falls among elderly are a major public health problem, but preventive interventions containing physical exercise and home improvement are available.

In this study the crucial question was to test whether unlicensed staff, assistant nurses, could be used for preventive work.

Estimation of study power gave that 170 participants in each group would be needed to detect a difference in days with falls, the main outcome measure.

Eligibility Criteria:
Inclusion Criteria:

* community living persons at least 65 years old
* independent walking ability with or without walking aid
* experienced at least one fall during the last 12 months
* ability to communicate and cooperate with study staff

Exclusion Criteria:

* ongoing physiotherapy treatment
* ongoing participation in exercise/acitivity containing balance and strength enhancing components
* a dementia diagnose
* mental disorder that affects possibility to communicate and cooperate
* other medical reason making participation inte the study inappropriate.
Can Medical Personnel Properly Proceed in the Case of a Patient With Bradycardia?

The study aims to assess the regularity of the proceedings in the case of a patient with bradycardia ECG.


Eligibility Criteria:
Inclusion Criteria:

* give voluntary consent to participate in the study
* maximum 1 year of work experience in medicine
* paramedics, nurses, physicians

Exclusion Criteria:

* not meet the above criteria
* wrist or low back diseases
* pregnancy
Assessment of Thoracolumbar Fascia Length

The purpose of the study is to compare the elasticity of thoracolumbar fascia in patients with and without subacromial impingement syndrome.

30 patients diagnosed as subacromial impingement syndrome in physical medicine and rehabilitation department of Baskent University will be recruited as group 1. 30 healthy volunteers will be recruited as group 2. Visual Analogue Scale (VAS) with the aim of assessing pain severity, tape measurement for posterior capsule shortness; body lateral flexion, rotation and extensor movements and lumbar extensor shortness will be observed for correlation with thoracalumbal fascia flexibility. Lateral flexion, flexion, and extension movements will be measured using goniometry for trunk normal joint movements. The thoracolumbar fascia length test and Modify Schober test will be used for thoracolumbar fascia length.


Eligibility Criteria:
Inclusion Criteria:

* 30 patients with Subacromial Impingement Syndrome and 30 volunteers
* between ages of 20-40 years
* both sexes

Exclusion Criteria:

* having lumbar surgery
* having problem with lumbar region in last 6 months
* having scoliosis
* radiologically diagnosed kiphosis
* MR diagnosed lumbar and thoracic herniation
* positive sacroiliac tests
* restricted pelvic motion
* having scapular dyskinesia
Managing Hypertension Among People Living with HIV

The Managing Hypertension Among People Living with HIV: An InTegrated Model (MAP-IT) a stepped wedge, cluster-randomized controlled trial to evaluate the effect of practice facilitation (PF) on the integration of a Task-Shifting Strategy for hypertension (HTN) control (TASSH) into HIV care for management of HTN in people living with HIV (PLWH). The study will recruit 960 PLWH across 30 primary health centers (PHCs) in Akwa Ibom State (32 patients/PHC).

People Living with HIV (PLWH) are at increased risk for non-communicable diseases (NCDs) including cardiovascular diseases (CVD) with hypertension (HTN) the most common. Integrating NCD management into HIV chronic care services may be a cost-effective strategy to mitigate the rising burden of NCDs in PLWH. The goal of the study is to evaluate the effectiveness of practice facilitation in the integration of a task-shifting strategy for hypertension control into HIV care service delivered in primary health centers in Akwa Ibom State, Nigeria.

This study will occur in two phases: 1) The first phase is a UG3 Planning Phase during which investigators will use the iPARiHS implementation science framework to explore factors and support systems required for successful implementation and integration of TASSH into existing HIV chronic care platform and development of a context-specific practice facilitation strategy. 2) The second phase, which is the focus of this record, is a UH3 Implementation Phase during which we will use a stepped-wedge, cluster RCT, guided by the RE-AIM implementation science framework, to evaluate the effect of practice facilitation strategy on the level of adoption of TASSH, hypertension control, and level of sustainment of TASSH in management of hypertension among 960 patients enrolled in HIV treatment services across 30 PHCs.

Eligibility Criteria:
Inclusion Criteria:

1. Persons aged 18 years or older
2. Be HIV positive and currently enrolled in HIV treatment services at one of the 30 study PHCs, be receiving HTN treatment services at one of the 30 study PHCs, or can be enrolled at one of the 30 study PHCs to receive HTN services for the entire study duration.
3. Have elevated blood pressure between 140-179 mm Hg systolic and/or 90-109 mm Hg diastolic, as determined by the average of the latter two of three separate BP readings during one clinic visit
4. Able to provide consent

Exclusion Criteria:

1. BP ≥180/100 mm Hg
2. Known history of kidney disease, heart disease, diabetes mellitus, stroke
3. A female who is pregnant or breastfeeding at the time of enrollment
4. Inability to provide informed consent
5. Refusal to participate in the study
Augmenting Buried in Treasures Workshop (BIT) With In-home Decluttering Practice for Individuals With Hoarding Disorder

Patients participate in Buried in Treasures Workshop (BIT) that has been shown to improve symptoms of hoarding disorder. To target levels of clutter, the investigators are testing an intervention to add in-home decluttering practice to the BIT workshop.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or older at consent
* Primary hoarding disorder, Saving Inventory Revised greater than or equal to 40.
* Clutter Image Rating Scale greater than or equal to 3 and less than or equal to 7.
* Low risk for eviction
* English speaking
* Will and able to understand and complete consent procedures

Exclusion Criteria:

* Hoarding disorder not primary
* Severely depressed individuals; Hamilton Depressions Rating Scale greater than 30 or judged clinically to be at risk of suicide with Columbia Suicide Severity Scale
* Unable or unwilling to allow study staff into home for home assessment OR a Clutter Image Rating Score of less than 2 or greater than 7.
* At risk for eviction
* Animal Hoarding or squalor of any kind
COVID-19 Vaccine Confidence Among Pregnant Women and Mothers

The purpose of this study is to assess the level of vaccine confidence and influencers among pregnant women and mothers of school-aged children during the COVID-19 pandemic.

The WHO has listed "vaccine hesitancy" as one of the top threats to global health.

The COVID-19 pandemic has triggered the need to vaccinate worldwide as soon as a safe and efficacious vaccine becomes available. However preliminary data show that, on average, only 50% to 66% of US adults would be willing to receive COVID-19 vaccination when it becomes available, a percentage lower than what is required for herd immunity to control the pandemic. Furthermore, there is a pressing need to vaccinate children to reopen schools and keeping them safe, as well as to immunize pregnant women through vaccination programs since they constitute a vulnerable population. Vaccine confidence among pregnant women and mothers of school-aged children during the period of COVID-19 pandemic is unknown, leading to an important gap of knowledge that may hinder the upcoming global COVID-19 vaccination scale-up effort. It is therefore of critical importance to assess the level of vaccine confidence and influencers among pregnant women and mothers of school-aged children during the COVID-19 pandemic.

The international nature of the proposed survey will allow the evaluation of vaccine confidence and its influencers among pregnant women and mothers of school-aged children on a global level. Therefore, social and geographic characteristics from different countries and cultures will be available for comparison. The resulting knowledge will be relevant to a large percentage of the world's population. Any country in the world can participate.

Eligibility Criteria:
Inclusion Criteria:

* Pregnant women or women who have at least one child younger than 18 years of age. Able to give electronic informed consent

Exclusion Criteria:

* \<18 years of age
Guangzhou Women's Health Cohort Study (GWHCS)

The Guangzhou Women's Health Cohort Study aims to explore the health trajectory and factors contributing to the health of women aged 35-64 in Guangzhou. Based on multiple population health registration data platforms, data of the cohort will provide information about the health of women across the lifespan, facilitating the decision-making process by local government . The cohort is progressing steadily, and the goal is to build a large women cohort covering 11 administrative districts of Guangzhou with a scale of 1 million by 2030.

The Guangzhou Women's Health Cohort Study aims to explore the health trajectory and factors contributing to the health of women aged 35-64 in Guangzhou. Based on multiple population health registration data platforms, data of the cohort will provide information about the health of women across the lifespan, facilitating the decision-making process by local government . The cohort is progressing steadily, and the goal is to build a large women cohort covering 11 administrative districts of Guangzhou with a scale of 1 million by 2030.

Eligibility Criteria:
Inclusion Criteria:

* Women aged 35-64 years old
* Women with registered permanent residence in Guangzhou
* Women with informed consent

Exclusion Criteria:

* Women without informed consent
* Women with reading and/or writing difficulties
* Women with serious mental disorders