cyrilzakka/clinical-trials huggingface dataset:
Surefire Institutional DEB-TACE

The purpose of this study is to determine the feasibility and safety of the Surefire Infusion System (SIS) for delivery of Drug Eluting Beads Transcatheter Chemoembolization (DEB-TACE) in the HCC population. This study will allow us to determine the effectiveness of SIS for HCC in terms of disease response.

This is a single arm pilot study to evaluate the technical feasibility and safety of performing DEB-TACE using the investigational delivery device: Surefire Infusion System (SIS). Patients presenting with primary liver cancer without evidence of metastatic disease or vascular invasion will be considered for the trial. Patients enrolled in the trial will undergo 1 or 2 sessions of DEB-TACE delivered through SIS as determined by the performing interventional radiologist. Decision for second treatment will be based on the degree of disease burden and vascular anatomy demonstrated on the first treatment session. To limit potential hepatotoxicity, patients with multifocal disease in a single lobe may be treated with a 2nd treatment with the investigational device. Patients with a large lesion being supplied by multiple vessels may also undergo a 2nd treatment session based on the investigator's judgement. The decision to proceed with a second treatment will be determined at the time of the first treatment based on disease burden and vascular anatomy. There will be an interval of 2-4 weeks between treatments. All patients undergoing 2nd treatment will have a repeat laboratory evaluation with treatment deferred for 2-4 weeks for those not meeting initial inclusion criteria. For patients who labs have not normalized at this time will not undergo a 2nd treatment.

Eligibility Criteria:
Inclusion Criteria:

1. Primary liver cancers based on biopsy or imaging criteria
2. Child-Pugh A or B7 liver disease
3. Bilirubin \<2.0 mg/dL
4. Albumin \>3.0 gm/dL
5. ECOG status 0 or 1
6. Adequate renal function

   a. Creatinine \< 2.0 mg/dL
7. Age 18 or older
8. Able to understand informed consent
9. Life expectancy \> 3 months
10. Women of childbearing potential must have a negative serum/urine pregnancy test on the day of planned procedure.

Exclusion Criteria:

1. Portal vein thrombus
2. Uncontrolled ascites
3. Hepatic encephalopathy
4. Uncorrectable coagulopathy (platelets \<50,000, INR \>1.50)
5. Untreatable contrast allergy
6. Pregnancy
7. Symptomatic congestive heart failure
8. Prior systematic therapy for HCC
Adjuvanted Influenza Vaccine Effectiveness in the Elderly (65+Yrs)

This study explores the hypothesis that the use of an adjuvanted influenza vaccine in the elderly will produce greater vaccine effectiveness in their group.

To evaluate the effectiveness of adjuvanted trivalent inactivated influenza vaccine in the elderly (aged ≥ 65 years) through the reduction in relative risk of microbiologically confirmed influenza illness

Eligibility Criteria:
Inclusion Criteria:

1.Elderly tested for influenza as part of routine clinical care in the Lower Mainland and on Vancouver Island during the influenza season.

Cases: Proven influenza diagnosed on naso-pharyngeal swab via PCR Controls: Elderly with influenza-like-illness testing negative for influenza during the influenza season.

Exclusion Criteria:

1. Known immunodeficiency disorders (including HIV)
2. Current or recent (within 90 days prior to first dose of influenza vaccine) immunosuppressive treatment including chronic oral steroids (1mg/kg for \> 4 weeks), cytotoxic chemotherapy, radiation therapy, other immunosuppressive drug and biologic agents Note: Use of topical or inhalant corticosteroids is acceptable.
3. Administration of immunoglobulins during the study period;
Sexual Dysfunction and Dental Care

Evaluation of sexual functioning of patients at the Sexual Medical Center, at Sheba Medical Center in Israel. Sexual functioning shall be compared with their dental behavior.

Hypothesis: a positive association will be found.

Patients, male and female, age over 18, who apply to the Sexual Medical Center, at Sheba Medical Center will fill a battery of questionnaires regarding their sexual function and dental treatment.

Eligibility Criteria:
Inclusion Criteria:

* Men and women, over 18 years old, who come for sexual therapy/ counseling to the Sexual Medical Center, in Sheba Medical Center, Israel Partners or spouses of the above.

Exclusion Criteria:

* Patients who are already in the middle of treatment.
Methods of Assessment of Adenoid Size

Chronic nasal obstruction due to adenoid hypertrophy is among the most common health problems affecting children, and adenoidectomy is one of the most common surgical procedures performed in this age group Because of difficulties associated with the use of the objective methods (such as nasopharyngeal endoscopy) in young children, the development of a reliable scale based on the child's symptoms to properly evaluate the need for surgical intervention would be of great value for clinicians. When adenoidectomy is being considered, the diagnosis and documentation of adenoidal hypertrophy become an important issue. Numerous modalities have been used for this task, including trans oral digital palpation and trans oral mirror examination; however, these methods are quite impractical with uncooperative younger children

Assessment of the nasopharynx and adenoids by fibreoptic examination bears the advantage of direct visualization of the postnasal space. In addition, previous studies have demonstrated that adenoid size, as determined by rhinoscopy, was well correlated with clinical symptoms such as nasal obstruction and snoring.

The aim of this study was to compare the effectiveness of lateral neck radiography and video rhinoscopy in assessing adenoid size .

Assessment of the reproducability of these modalities to associated symptoms and, thus, the severity of the disease.

Eligibility Criteria:
Inclusion Criteria:

* children aged 3 _ 14 years old
* clinical diagnosis of adenoid hypertrophy in the form of chronic oral respiration , nasal disorders and snoring
* recurrent otitis media

Exclusion Criteria:

1. patients diagnosed with nasal obstruction due to anatomic malformation ( congenital, choanal atresia, stenosis or septal deviation )
2. age less than 3 years or more than 14 years
3. patient with craniofacial malformation and down syndrome
Using Information Technology to Improve Outcomes for Children Living With Cancer

This proposed study plans to develop and evaluate a patient-oriented, technology-based, symptom monitoring system that reports symptoms experienced by children with cancer to their parents and health care providers.

Cancer is a leading cause of death and disability in children under 15 years of age. Its unrelieved symptoms and side effects of often-aggressive treatments can lead to poor psychosocial functioning and decreased health-related quality of life (HRQOL) for patients and their families. Barriers at the patient, healthcare provider and system levels can contribute to poor symptom management. A technology-based program can minimize these barriers by routinely collecting and interpreting patient-reported outcomes (PROs) and patient/parent contextual data in pediatric oncology ambulatory settings in a manner that is efficient, actionable by physicians, supports engagement of patients and families with their health and care, and improves clinical processes and outcomes. This proposed project will develop and evaluate the effectiveness of such a program: Symptom Monitoring \& Systematic Assessment and Reporting System in Young Survivors (SyMon-SAYS). We hypothesize that the SyMon-SAYS intervention will decrease parent-perceived barriers to managing their child's symptoms, decrease patient symptom burden, increase patients' and parents' self-efficacy, and ultimately increase patient HRQOL.

Eligibility Criteria:
Inclusion Criteria:

Patients

* Have an hematology/oncologic diagnosis (including a brain tumor)
* Be on-treatment or within 6 months post-therapy
* Be between 8 and 17 years old
* English-speaking
* Have sufficient cognitive and motor abilities to complete survey via an electronic device (e.g., smartphone, iPAD, etc.) or computer
* Be able and willing to sign assent forms (for those 12-17 years old).

Parent/legal guardian

* Be a parent (father or mother) or a legal guardian of eligible patients
* Demonstrates sufficient English and/or Spanish ability to understand and sign the informed consent form
* Have sufficient cognitive and motor abilities to complete survey via an electronic device (e.g., smartphone, iPAD, etc) or computer

Exclusion Criteria:

* Patients who cannot understand English sufficiently to sign consent/assent form
* Patients who cannot understand English sufficiently to complete the questionnaires
Mobile Educations Effect on Pain Outcomes

The purpose of this study is to explore the clinical impact of pain management education using a mobile web-based education delivery system compared to standard education delivery. This study seeks to understand the difference between two different education delivery methodologies and the effect on the postoperative pain experience, including participation in treatment plan, knowledge, pain outcomes, and opioid requirements in patients undergoing major hip (THA) and knee (TKA) arthroplasty. It is hypothesized that a real-time, interactive, mobile education system will demonstrate improved pain associated outcomes and higher patient participation when compared to the current standard education delivery method.


Eligibility Criteria:
Inclusion:

* Adult patients
* over the age of 18 years
* undergoing surgical intervention and inpatient care for one of the following procedures:
* total hip arthroplasty (THA) (primary, bilateral, and revision)
* total knee arthroplasty (TKA) (primary, bilateral, unicompartmental, and revision)
* Fluent in the English language

Exclusion:

* Undergoing more complex hip and knee procedures such as:
* implant resections with or without spacer placement
* liner exchange
* THA or unipolar hip arthroplasty related to repair of hip fracture.
* Preexisting physical or cognitive limitations that would hinder their ability to use the mobile application
Gastrointestinal Dysmotility on Aspiration Risk

The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.


Eligibility Criteria:
Inclusion Criteria:

1. are 5-21 years of age;
2. receive \>90% of their calories by enteral tube (i.e., patients take no food or drink by mouth);
3. are determined to be at high risk for aspiration pneumonia based on evidence of impaired airway protective mechanisms, documented by aspiration on video fluoroscopic swallow study;
4. have static neurologic impairment, defined as functional and/or intellectual impairment that results from a chronic neurologic or related diagnosis (e.g., cerebral palsy) with no prospect of progression for at least one year;
5. have chronic respiratory symptoms, defined as coughing, choking, or need for oral suctioning a minimum of three times per week during the prior four weeks.

   -

Exclusion Criteria:

1. have progressive neurologic impairment;
2. have a history of prior intact Nissen fundoplication;
3. are currently taking oral or inhaled antibiotics, including prophylactic antibiotics;
4. are currently taking or have taken in the last four weeks acid suppression (H2 antagonist or PPI); or
5. are fed by gastrojejunostomy rather than by gastrostomy. -
The Application of Kinesio Taping Technique in the Early Upper Limb Functional Activities Induction of Hemiplegic Patients After Stroke

1. To observe the inducing and promoting effect of kinesio taping technique on the recovery of upper limb function in early-stage stroke patients.
2. To compare the different effects of kinesio tape and sports white tape on the induction and promotion of limb function in patients.
3. To verify that kinesio taping technique is a safe and promotable technical means for stroke patients.


Eligibility Criteria:
Inclusion Criteria:

1. The subjects voluntarily participated in the experiment and signed informed consent
2. Diagnosed as a stroke patient
3. No other major cardiovascular and cerebrovascular diseases
4. First new stroke
5. After evaluation by evaluators, subjects had Brunnstrom stage \< 3

Exclusion Criteria:

1. The subject's compliance was poor
2. Increased muscle tone in the affected upper extremity
3. Subjects with skin allergies
4. Those who did not receive continuous treatment during the experiment
Comparison Between Sit-to-stand Test and Six-minute Walk Test in Chronic Obstructive Pulmonary Disease

Comparison between sit-to-stand test and six minutes walking test in chronic obstructive pulmonary disease patients


Eligibility Criteria:
Inclusion Criteria:

* clinically stable for a minimum of 4 weeks
* no recent infectious exacerbations

Exclusion Criteria:

* musculoskeletal or joint disorders
* contra-indications to perform exercises
Fractional Nonablative 1540 nm Laser Resurfacing for Burn Scars- A Randomised Controlled Trial

The objective was to evaluate the efficacy of 1540 nm fractional laser treatment of mature burn scars.


Eligibility Criteria:
Inclusion Criteria:

* Burn scars with and without previous skin grafting.

Exclusion Criteria:

* A tendency to produce hypertrophic scars or keloids,
* Previous treatment with dermabrasio, chemical peel, filler, laser treatment or Intense Pulsed Light (IPL) of study areas,
* Photosensitivity,
* Pregnancy or lactation,
* Current anticoagulative medication,
* Oral retinoid drugs within the past 6 months,
* Pigmentation after recent exposure to sun or solarium,
* Patients not considered to be able to follow the treatment protocol.
Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation

The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and effect on brain injury markers of targeting low or high normal arterial oxygen tension (PaO2), arterial carbon dioxide tension (PaCO2) and mean arterial pressure (MAP) in comatose, mechanically ventilated patients after out-of-hospital cardiac arrest. Using factorial design, participants are randomized at admission to intensive care unit to one of eight groups targeting either low or high normal values of PaO2, PaCO2 and MAP for 36 h. In this way, investigators will be assessing the feasibility and effect of all three variables at the same time.

The primary outcome is serum concentration of neuron-specific enolase (NSE) at 48 h after cardiac arrest. Feasibility outcome is between-group separation in PaO2, PaCO2 and MAP levels. Secondary outcomes include continuous monitoring of cerebral oxygenation, EEG and ECG for 48 h, the levels of NSE, S100B and cardiac troponin at randomization and 24, 48 and 72 h after cardiac arrest and neurological assessment at 6 months after cardiac arrest.


Eligibility Criteria:
Inclusion Criteria:

* Witnessed out-of-hospital cardiac arrest with ventricular fibrillation (VF) or ventricular tachycardia (VT) as the initial rhythm
* Delay of return of spontaneous circulation (ROSC) 10-45 min from the start of the arrest
* Confirmed or suspected cardiac origin
* Mechanical ventilation
* Markedly impaired level of consciousness (no response to verbal commands and Glasgow coma scale \[GCS\] motor score \< 5)
* Deferred consent possible or likely
* Active intensive care initiated, including targeted temperature management (33-36 C)

Exclusion Criteria:

* Probable withdrawal of active ICU care due to terminal illness or poor prognosis because of severely reduced functional status before cardiac arrest
* Confirmed or suspected intracranial pathology and/or suspicion of raised intracranial pressure
* Pregnancy
* Severe oxygenation problem (PaO2 / FiO2 \< 100 mmHg)
* Severe COPD
Efficiency of E-learning and Role-playing for the Training of Nursing Home Caregivers in the Support of Agitation in Neurodegenerative Diseases

This study will investigate the effects of "I-Learn cognition and behaviour" training in the care in agitation in patients with neurodegenerative diseases. This training for caregivers, aims to reduce agitation and psycho-behavioral disorders of patients living in nursing home. In addition, amount of psychotropic drugs prescribed, as well as the number of hospitalizations during the study will be assessed.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of Major Neurocognitive Disorder according to DSM 5
* With agitation and NPI agitation item score of 4 or more (frequency X severity)
* Information and verification of the non-opposition of the patient and his guardian / curator if he is under legal protection.

Exclusion Criteria:

* Patient under court protection
* Inability to understand the French language
* Patient whose state of health is not stabilised at the time of inclusion and/or in palliative care
Clinical Trial of the Impact of Treatment Consultation Recordings on Cancer Patient Outcomes

The time period from diagnosis through to the end of treatment is challenging for patients. Patients need information, assistance with decision making, and emotional and social support to help cope with their diagnosis and treatment. The first meeting with the cancer doctor is especially anxiety-provoking for patients who will learn, for the first time, their treatment options and likelihood of being cured. This anxiety causes many patients to have difficulty remembering the important pieces of information that their cancer doctor tells them during this consultation. The main goal of this study is to demonstrate the benefits of giving cancer patients an audio-recording of their first consultation with their cancer doctor. The investigators will include newly diagnosed patients from cancer centres in Winnipeg and Calgary. The types of cancer that will be included in this study are brain and neuroendocrine. Patients with these types of cancer are more likely to have confused thinking, and therefore may have the most to gain from receiving their consultation recordings. The study will include 244 patients, and those who sign consent forms to participate will be assigned by chance to either receive their treatment consultation recording or not. Patients will receive their recording immediately after their consultation, and will be able to listen to the recording at any time either alone, or with family and friends. To figure out whether the consultation recording provides patients with benefits, the investigators will administer some questionnaires to patients at 1 week after the consultation, and again at 3 and 6 months after the consultation. These questionnaires will assess the following patient outcomes: i) anxiety and depression, ii) perception of being informed about the disease and treatment, iii) satisfaction with cancer care, iv) satisfaction with the doctor, and v) the extent to which patients are satisfied with their degree of involvement in treatment decision making. The investigators hypothesize that patients who receive their consultation recording will experience more benefits than patients who do not receive their consultation recording.


Eligibility Criteria:
Inclusion Criteria:

* presenting with a primary diagnosis of non-recurrent or metastatic brain, or neuroendocrine cancer
* 18 years of age or older
* able to read and communicate using the English language
* access to a computer to enable consultation playback

Exclusion Criteria:

* deemed by a treating clinician (or primary nurse for the treating clinician) to have any severe psychiatric condition or cognitive dysfunction that precludes provision of free and informed consent to participate
Cannabis Versus Oxycodone for Pain Relief

This study investigates the ability of cannabis to reduce chronic back and neck pain and to reduce sensitivity to an acute painful stimulus. Cannabis will be compared to both oxycodone and a placebo.

This study investigates the ability of cannabis to reduce chronic back and neck pain and to reduce sensitivity to an acute painful stimulus. Cannabis will be compared to both oxycodone and a placebo.

Some inclusion/exclusion criteria are purposely omitted at this time to preserve scientific integrity. They will be included after the trial is complete.

Eligibility Criteria:
Overall Inclusion Criteria:

* Previous smoked or vaporized cannabis exposure
* Age ≥21 years

Overall Exclusion Criteria:

* Current substance use disorder
* Current alcohol use disorder
* Past cannabis abuse/dependence
* Current use of amphetamine/methamphetamine, barbiturates, benzodiazepines, cocaine, phencyclidine (PCP), MDMA (ecstasy)
* Prior adverse reaction to cannabis exposure (paranoia, anxiety, etc.)
* Allergy to or prior adverse reaction to oxycodone
* Any condition contraindicative to opioid use (e.g. paralytic ileus)
* History or diagnosis of schizophrenia or bipolar disorder
* Current severe depression
* Uncontrolled hypertension (\>139/89)
* Known cardiovascular disease
* Known immune system disorder
* Chronic pulmonary disease (e.g., bronchitis, asthma, COPD, or emphysema)
* History of seizure disorder
* Diagnosed inflammatory disease (e.g. Rheumatoid Arthritis (RA))
* Clinically significant abnormal values on CBC/CMP/EKG tests
* Cognitive disability that interferes with ability to provide consent or understand study procedures
* Inability to refrain from using tobacco for at least 4 hours
* Pregnant females
* Lactating females

Additional Exclusion Criteria for SPINE PATIENTS

* Current regular use of a long acting opioid (e.g. OxyContin, MS Contin, other extended release formulas)
* Current high-dose use of immediate release opioid
* Current high-dose use of nerve-targeted medication
* Other diagnosed chronic pain syndromes of greater severity than spine condition (e.g. knee pain )
* Diagnosed Fibromyalgia
* Neuropathy not associated with spine condition (e.g. diabetic neuropathy)

Additional Exclusion Criteria for HEALTHY CONTROLS

* Current acute pain
* Current chronic pain condition (e.g. fibromyalgia, neuropathy)
Correlation Between Dental Caries Prevalence in Primary Teeth and First Permanent Moilar of Children in Mixed Dentition Stage

to find the clinical relation between caries experience in primary teeth and first permanent molar in mixed dentition stage using def index for primary teeth , DMF index for first permanent molars and to find the clinical relation between caries prevalence in the selected children in relation with other associated factors such as age, sex tooth brushing frequency, dietary habits and mother's attitude toward child's oral health.

the problem for which the study held is lacking of data about relation between prevalence of dental caries in primary teeth and first permanent molar of the same child in mixed dentition stage, incidence of dental caries is influenced by number of risk factors such as age, sex dietary and oral hygiene habits identifying high risk individuals helps development of systemic approaches for preventive oral care programs world wide Dental caries is the major public health problem in most high income countries, affecting 60-90%of school children and the vast majority of adults. it also the most prevalent oral disease in several Asian and Latin American countries Although for the moment it appears to be less common and less severe in the greater part of Africa, the WHO report 2003 anticipates that in light of changing living conditions and dietary habits, the incidence of dental caries will increase in many of that continent's low income countries(WHO,2006)

Eligibility Criteria:
Inclusion Criteria:

* egyptian children
* children without systemic disease syndromes and disabilities
* first permanent molars fully erupted and in occlusion
* acceptance of the children's parents to participate in the study

Exclusion Criteria:

* any of first permanent molars aren't fully erupted or not in occlusion
* children suffering from any systematic disease that affect teeth development