cyrilzakka/clinical-trials huggingface dataset:
Lateral Occlusion of Uterine Artery in Total Laparoscopic Hysterectomy

Laparoscopic hysterectomy is associated with complications in form of infections and subsequently dehiscence of the vault. This is a serious complication. The infection may be related to the frequently observed postoperative hematoma following traditional laparoscopic hysterectomy where the uterine artery is coagulated and divided at the cervical entry into the uterus.

By coagulation of the uterine artery laterally close to the internal iliac artery this problem may be eliminated due to the much less bleeding observed during this procedure.

Laparoscopic hysterectomy (removal of the uterus) is today a well-described method for the removal of the uterus. The operation is offered in case of bleeding disorders where other treatments have been unsuccessful, uterine fibroids or other conditions requiring surgery with removal of the uterus.

The operation is done today in most cases by dividing the uterine artery at the entrance to the cervix, where the artery divides into one ascending and descending branch.

The most common complication of hysterectomy is bleeding perioperative well as postoperatively, which may result in a hematoma above the vaginal vault.

Through the years different methods have been tried to reduce this complication, including tranexamic acid without great success. The hematoma may result in infection postoperative and subsequent poor healing, with the possibility of dehiscence of the vault.

In the worst case, the gut is displaced through the vagina postoperatively. This condition can lead to diffuse peritonitis, which can be fatal in rare cases.

Since the hemostasis related to the dividing of the artery uterine can be problematic, especially in case of fibroids it may be a technical advantage to coagulate the Uterine artery at the exit of the Internal Iliac artery. This operation also ensures identification of the ureter, which can be spared. Lesions to the ureter are detected in up to 1% of all surgical procedures at hysterectomy.

Dividing of the Uterine artery at the Internal Iliac Artery also ensures that the artery can be divided with minimal bleeding at the cervix.

Eligibility Criteria:
Inclusion Criteria:

* Women submitted to total laparoscopic hysterectomy

Exclusion Criteria:

* Women \<18 years
* Women no able to understand the study or not native in Danish
* Women with uterine malignancy
* Women with suspicion of pelvic mass
* Women with abnormal coagulation
* Women receiving glucocorticoid treatment
* Women receiving anticoagulant treatment or have not followed prescription in relation to surgery
A Study Evaluating the Onset-of-Action, Safety, and Efficacy of RDX227675 for the Treatment of Hyperkalemia

This phase 2, single-blind, placebo-controlled study will evaluate the onset-of-action, safety, and efficacy of RDX227675 for the treatment of hyperkalemia. Subjects who qualify are randomized into one of four treatment groups: Group 1 (Placebo qd), Group 2 (RDX227675 10 g qd), Group 3 (RDX227675 20 g qd), Group 4 (RDX227675 30 g qd).

The study consists of a screening visit, a 7-day treatment period, and a 7-day treatment-free follow-up period.

Eligibility Criteria:
Inclusion Criteria:

* 18 to 85 years old, inclusive
* Two consecutive i-STAT K values ≥ 5.5 to \< 6.5 mmol/L, measured a minimum of 60-minutes apart within 1 day of first RDX227675 dose on Day 1 (prior to randomization)
* i-STAT K value ≥ 5.5 to \< 6.5 mmol/L on Day 1 (prior to randomization)
* Ability to have repeated blood draws or effective venous catheterization
* Females of child bearing potential must have negative urine pregnancy test on Day 1 (prior to randomization)
* Females but be non-pregnant, non-lactating, and either be post-menopausal for at least 12 months, have documentation of irreversible surgical sterilization, or confirm the use of one of the acceptable contraceptive methods
* Males must agree to use an appropriate method of contraception or have documented surgical sterilization

Exclusion Criteria:

* Pseudohyperkalemia signs and symptoms
* Treatment with K lowering drugs, within 7 days prior to randomization
* Uncontrolled Type 2 diabetes, as defined as most recent historical HbA1c \> 10%, or hospitalization to treat hyper- or hypo-glycemia in the past 3 months
* Diabetic ketoacidosis
* Known hypersensitivity to polystyrene sulfonate
* Significant cardiovascular or cerebrovascular events in the past 2 months
* Severe heart failure, defined as NYHA (New York Heart Association) class IV or hospitalization to treat heart failure in previous 3 months
* History of bowel obstruction, swallowing disorders, severe gastrointestinal disorders, or major gastrointestinal surgery
* Major psychiatric disorder (DSM-III-R or DSM-IV) including major depression or other psychoses that has required hospitalization in the last 3 years. History of attempted suicide or uncontrolled bipolar disorder.
* Use of an investigational product within 30 days prior to Screening
PLATINUM Diversity

To compile acute procedural performance and clinical outcomes data for the Promus PREMIER everolimus-eluting coronary stent system in understudied/underserved patient populations including women and minorities.


Eligibility Criteria:
Inclusion Criteria:

* Patient must be at least 18 years of age
* Patient must sign informed consent form
* Patient has received at least one Promus PREMIER stent
* Patient self-identifies as one or more of the following:

  * Female
  * Black of African Heritage
  * Hispanic/Latino
  * American Indian or Alaska native

Exclusion Criteria:

* Not applicable
Nutritional Supplementation in Geriatric Hip Fractures

This study is a randomized controlled trial comparing outcomes between geriatric hip fractures who received a commercially available (XR RecoveryTM, Salt Lake City Utah) peri-operative nutritional supplement for three weeks post-operatively to those who receive standard nutritional counseling. The main question it aims to answer is:

- Does supplementation decrease muscle loss via ultrasound measurements of the cross-sectional area of the rectus femoris of the uninjured leg?


Eligibility Criteria:
Inclusion Criteria:

1. Male or female, aged 65 years or older.
2. Presenting with a geriatric hip fracture (femoral neck, intertrochanteric, or subtrochanteric) requiring surgical intervention.
3. Able to provide informed consent.
4. Expected to survive at least 6 months after surgery, with no terminal illness.

Exclusion Criteria:

1. Pre-existing conditions that significantly impair mobility prior to injury.
2. Severe renal or liver impairment.
3. Active treatment with investigational drugs or participation in another clinical trial within the last 30 days.
4. Inability to tolerate oral nutritional supplementation due to gastrointestinal disorders.
5. Allergies to any components of the nutritional supplement being tested.
Spirometry in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients

Patients with COPD who deteriorate to Respiratory Failure pose a challenge to the intensivist both in ventilating an obstructed patient and in weaning from mechanical ventilation.

Currently there are no accepted extubation criteria in COPD patients that could predict successful weaning from mechanical ventilation. In this study we will attempt to correlate spirometric data to eventual weaning from mechanical ventilation.

COPD patients who deteriorate to Respiratory Failure will be recruited. Sedation will be interrupted daily, and each day once the patient is awake and cooperative, spirometry will be performed. FEV1 and FVC will be recorded and later correlated to eventual rate of successful extubation.

Eligibility Criteria:
Inclusion Criteria:

* \>18
* Mechanically ventilated due to COPD exacerbation

Exclusion Criteria:

* decreased level of consciousness
* uncooperative patient
* Bronchial asthma
Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin

The extraction of deep impacted mandibular third molar may cause periodontal defects at the distal root of the second molar. The aim of this study was to evaluate the ability of platelet-rich fibrin (PRF) in preventing periodontal complications at the distal root of the second molar adjacent to the extracted third molar.

Eighteen young patients with bilateral impacted mandibular third molars will be selected. All 36 cases of impactions will be selected for a split mouth study and randomly treated by using 2 different therapeutic approaches, thereby yielding 2 different study groups, each of which is composed of 18 cases: in one side the post-extraction socket is left healing spontaneously, on the other side the socket is filled with PRF.

CAL at the distal surface of the lower second molar is chosen as primary outcome.

Criteria will be the presence of a pocket distal to the mandibular second molar with a probing depth \>7 mm and a probing clinical attachment level \>6mm.

This study was designed as a single-blind research since subjects will be unaware of their treatment allocation. A software will be used to produce a random sequence of 18 integer numbers without duplicates generated from atmospheric noise and concealed in closed envelopes by one of the investigators. At the time of the patient's first surgery, the envelope will be opened and patient allocated either to group 1 (PRF on the right side, spontaneous healing on the left side), for allocation numbers 1-9, or group 2 (spontaneous healing on the right side, PRF on the left side), for allocation numbers 10-18.

One clinician, not involved in patient treatment and not aware of what therapeutic approach used for the different sites of treatment, will perform all clinical measurements (PD, CAL, gingival recession, plaque index and gingival bleeding index) before and after 12 and 18 weeks of surgery.

Clinical and radiographical measurements will be recorded at 12 and 18 weeks after the surgery. The Student t test will be used to compare the differences between the 2 groups.

Eligibility Criteria:
Inclusion criteria Patients of both genders and any race, between 18 and 35 year-old

* Periodontally health patients and treated periodontally compromised patients
* Enrollment on a regular supportive periodontal therapy (SPT) program.
* Full-mouth plaque score (FMPS)\< 25% at baseline;
* Full-mouth bleeding score (FMBS)\< 25% at baseline;
* Patients having bilateral mesioangular impacted mandibular third molars with the presence of a pocket distally to the mandibular second molar with a probing depth (PD) ≥7 mm
* Intact buccal and lingual cortical bone of the post-extraction site

Exclusion Criteria:

* General contra-indications for surgery (systemic disease, compromised immune system etc);
* Tobacco smoking
* Pregnancy and lactation
* Untreated periodontal conditions;
* Acute infection in the site of the extraction
* Patients taking any medications which might interfere with coagulation
* Platelet count \< 150000/mm3
Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).
2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer
3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.
4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.


Eligibility Criteria:
Inclusion Criteria:

* Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)
Vascular Effects of Carvedilol Versus Metoprolol in Hypertensive Patients With Type 2 Diabetes

The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.

Carvedilol and metoprolol are two commonly used blood pressure medications that have both been shown to be effective in controlling hypertension. Although in the same drug class, preliminary data have shown that these medications may have different vascular effects. This study will assess which medication is better at improving artery health independent of their blood pressure lowering effects. Artery health will be assessed non-invasively by ultrasound. Certain markers of atherosclerosis found in the blood will also be measured.

Eligibility Criteria:
Inclusion Criteria:

* Age 30-80 years old
* Documented history of type 2 diabetes
* Stable angiotensin converting enzyme/angiotensin receptor blocker (ACE/ARB) regimen 30 days before and throughout the study period
* Stable anti-diabetic regimen throughout the study period
* Body mass index (BMI) between 22-45 kg/m2
* HbA1c between 6-9% for patients on anti-diabetic treatment regimen and HbA1c between 6-8% for patients who are being controlled by diet alone
* Screening blood pressure (BP) \> 130/80 (average of 3 sitting measurements), with current medications

Exclusion Criteria:

* Uncontrollable or symptomatic arrhythmias
* Unstable angina
* Sick sinus syndrome or second or third degree heart block
* Decompensated heart failure
* Myocardial infarction (MI) or stroke within 3 months of screening
* Bradycardia
* Chronic obstructive pulmonary disease (COPD) with required inhaled or oral bronchodilators or corticosteroids
* Bronchial asthma or related bronchospastic conditions
* New onset/diagnosed type 2 diabetes (\<3 months)
* Clinically significant renal or liver disease (creatinine \>2.5 mg/dL)
* Endocrine disorders
* Use of anorectic or other diet drugs inconsistent with recommendations for type 2 diabetics
* Use of beta-blockers within 3 months of screening
* Use of corticosteroids
* Systemic disease, including cancer, with reduced life expectancy (\<12 months)
* Psychological illness/condition that interferes with comprehension of study requirements
* Use of an investigational drug within 30 days of entry into study
Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx.

The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled.

Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),


Eligibility Criteria:
Inclusion Criteria:

* patients in ICU
* indication for lipid administration as a part of TPN

Exclusion Criteria:

* shock or clinical/laboratory signs of tissue hypoperfusion
* previous lipid infusions (within 3 months before entering study)
* hyperlipidaemia
* hyperglycaemia (over 10 mmol/l)
* current or previous (within 72 hours before entering the study) use of propofol
* pancreatitis
* severe liver failure
* current use of statins
Evaluation of Negative Symptoms and Cognitive Function After Administration of Antipsychotics in Healthy Volunteer

The aim of the study is to investigate the negative symptoms and cognitive function after administration of antipsychotics in healthy volunteer.


Eligibility Criteria:
Inclusion Criteria:

* Aged 18-38 years and meet no DSM-IV diagnostic criteria as assessed by using the Structured Clinical Interview for DSM-IV, research version.

Exclusion Criteria:

* 1) anyone who participated in other clinical trials within 30 days from the start of this clinical trial or is currently participating in one,
* 2) anyone who has progressive disease or in unstable medical condition unfit for the trial,
* 3) anyone who has been diagnosed in psychiatric terms in the past, depends on psychotropic substance, or has overdosed or depended on the substance or alcohol (except for coffee or tobacco) within 1 month from the trial start,
* 4) anyone who is suicidal or highly probable of suicides, or
* 5) anyone who has test results considered clinically meaningful
Efficacy of AesyBite Active in Reducing Sleep Bruxism Activity

The overall objective of the clinical investigation is to evaluate whether the use of the AesyBite Active reduces the bruxism activity.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 to 70 years, in good general health.
* Presence of at least one of the following:

  * sleeping partner's report of tooth grinding sounds during sleep for at least three nights per week within the last 6 months,
  * hypertrophy of the masseter muscle upon digital palpation.
* Presence of at least one of the following:

  * signs of tooth attrition or shiny spots on dental restorations,
  * self-report of masticatory muscle fatigue or pain at awakening.
* Previous prescription of a night splint for bruxism.
* Able to understand and follow the protocol and complete the self-administered paper questionnaires.
* Able to provide written informed consent to study participation and storage and processing of study data

Exclusion Criteria:

* Allergic to Ethylene-Vinyl Acetate (EVA) copolymer.
* With more than two missing molars (excluding third molars).
* Ongoing orthodontic treatment (e.g. teeth alignment).
* With major neurological or psychiatric disorders including substance dependence.
* Using a removable dental prosthesis.
* Using a medication with known effects on sleep or motor behavior.
* Suffering from periodontal disease.
* With occlusal or jaw abnormalities that prevent the wearing of a normal dental splint.
* Participants with pacemakers.
HIERARCHY OF VISION

Little is known about the exact role of feedback in cortical processing. Hypotheses on its function range from attentional control to the transmission of Bayesian priors in the interpretation of sensory events, such as in the theory of Predictive Coding. Recent advances in identification of functional signatures of feedback and feedforward signal, as well as additional techniques based on causal relations in signal processing open a unique methodology for probing such processes in awake and behaving organisms and testing these theories and more generally the hierarchical processing between cortical areas.

The objective of this project is to study feedback and feedforward relations and localization in the well established pathways between cortical areas V1 and Medial Temporal (MT) that have been implicated in early integration processes in motion perception.


Eligibility Criteria:
Inclusion Criteria:

* Aged between 18 and 40 years old
* Affiliated to a social security scheme
* Be right-handed
* Have signed the informed consent

Exclusion Criteria:

* Subjects with a neurological or psychiatric history
* Subjects with visual disturbances not corrected
* Pregnant, lactating or childbearing women without contraception.
* Persons under guardianship, trusteeship or any other administrative or judicial measure of deprivation of rights or liberty, as well as adults protected by law.
* Participants refusing to be informed of the results of the medical examination.
* Participants refusing to be informed of the possible detection of an anomaly.
* Volunteers with contraindications to the MRI examination: people using a pacemaker or an insulin pump, persons wearing a metal prosthesis or an intracerebral clip as well as claustrophobic subjects, neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign body ocular or cerebral close to the nerve structures, agitation of the subject (non-cooperating or agitated subjects), ventriculoperitoneal neurosurgical bypass valves, dental apparatus.
Psychological Impact of Covid-19 Assiut University Hospital Experience

Psychological impact of covid-19 in assiut university hospital

Coronavirus disease 2019 (COVID-19) is a new communicable disease caused by the new strains of severe acute respiratory syndrome coronavirus, SARS-CoV-2 . The first outbreak reported was in December2019, in Wuhan, China, as pneumonia of unknown etiology linked to a seafood market exposure COVID-19 affects different people in different ways. Most infected people will develop mild to moderate illness and recover without hospitalization.

The evolution of the novel Corona Virus Disease (COVID-19) and its expeditious dissemination have led the World Health Organization (WHO) to declare it a pandemic on 11 March 2020 . As of 16 May 2020, there have been 4,425,485 confirmed COVID-19 cases and 302,059 related deaths worldwide and Egypt has been among the most affected countries in the Eastern Mediterranean region with 11,228 confirmed cases and 592 deaths .

As a consequence, many countries, including Egypt, have set a state of lockdown to hinder the spread of infection among people resulting in a global atmosphere of depression and anxiety associated with social isolation, fears of getting infected, breaks in the supply chains, financial distress, disrupted travel plans, and future uncertainty . Several epidemiological studies from China detected a high prevalence of psychological disturbances among the public during the COVID-19 pandemic. For example, a large online survey of 56,679 individuals from 34 provinces in China reported numerous psychological conditions during the COVID-19 pandemic: depression (27.9%), anxiety (31.6%), stress (24.4%), and insomnia (29.2%) . Also, a study conducted on 4872 Chinese people from 31 provinces showed a high prevalence of depression (48.3%) and anxiety (22.6%) related to the COVID-19 pandemic . A similar study revealed depression (20.1%), anxiety (35.1%), and poor sleeping (18.2%) among 7236 Chinese people . Another study conducted on 7143 college students in China detected anxiety among 25% of them .

In low- and middle-income countries, such as Egypt, where infection control precautions, surveillance programs, laboratory capacity, and public health resources are limited , the response to the COVID-19 pandemic is challenging and, as a result, the psychological impacts of the pandemic on the public can be even worse. Thus, we conducted this study to evaluate several forms of psychological disturbances .

Eligibility Criteria:
Inclusion Criteria:

* age more than 18 years old
* diagnosed as covid-19 by positive PCR
* comes to Assiut University Hospital
* both sex males and females

Exclusion Criteria:

* age less than 18 years old
* past history of psychatric disorder