cyrilzakka/clinical-trials huggingface dataset:
Comparative Study on Acute Pain Evaluation Between Spanish and French Hospital Emergency Unit

Today, pain is a difficult affordable subject in Spain. There are however 187 units of pain care with a consultations rate in emergency center of more than 60%.For example OXYCODONE(opioid analgesic)is widely used while it's under used in Spain.

In the same way MEOPA(Kalinox) is a new approach of pain care daily used as well in France (for example in dislocated shoulder pain, or ulceration care...etc) There are lots of studies relative to chronic pain but not too much about acute pain in Spain.That's why we want to focus our study on evaluation of acute pain treatment and efficacy in french and spanish hospital


Eligibility Criteria:
Inclusion Criteria:

* Patient admitted in emergency center for acute pain.
* Patient who accept to participate.

Exclusion Criteria:

* Refusal of patient to participate
Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy

This hypothalamic obesity is associated with serious metabolic and psychosocial consequences.

The purpose of the study is to compare the change of body weight after 6 months treatment with a lifestyle intervention + exenatide compare to the one after the same lifestyle intervention+ placebo in adults patients suffering from a hypothalamic obesity due to treatment of craniopharyngioma.

The development of glucagon-like peptide-1 (GLP-1) analogues might be a solution since native GLP-1 suppresses appetite and energy intake in both normal weight and obese individuals as well as in people with type 2 diabetes and delays gastric emptying. The underlying mechanisms that mediate the effects of weight involve not only central regions like the hypothalamus and the solitary tractus nucleus and area postrema but also peripheral regions as the gastrointestinal tract. These extra hypothalamic effects are of particular interest in the cases of obesity due to hypothalamic lesions.

Exenatide is a glucagon-like peptide-1 (GLP-1) analogue with a high structural homology to human GLP-1, a gut derived incretin hormone. Since exenatide causes a dose-dependent weight loss, decreasing concentration of glycosylated haemoglobin as well as improving ß-cell function and systolic blood pressure, it could be an attractive treatment for both type 2 diabetes and obesity. In a double-blind placebo-controlled 24-week trial, it has been recently shown that non diabetic obese patients maintained on exenatide 10µg x 2/j lost significantly more weight than did those on placebo (5.1 kg versus 1.6).

Eligibility Criteria:
Inclusion Criteria:

* They are between 18 and 75 yrs.
* They had been diagnosed with a craniopharyngioma treated by surgery and/or irradiation without sign of recurrence.
* They have a BMI upper than 30kg/m² with intractable weight gain following therapy for craniopharyngioma.
* They demonstrate at least one other endocrinopathy, as a marker of hypothalamic damage.
* All pituitary deficiencies are correctly treated.
* They gave their written, informed consent before the beginning of the study.

Exclusion Criteria:

* They have type 1 diabetes.
* They have type 2 diabetes treated with insulin.
* Acidocetosis.
* Bariatric surgery
* Previous personal history of thyroid or pancreatic cancer.
* Hypercalcitoninemia.
* They have been previously treated by GLP1 analogs.
* Hypertriglyceridemia upper than 5g/l
* They had previously demonstrated voluntary weight loss during the three previous months.
* They are under the age of 18 years or over the age of 65 yrs.
* They are maintained on medical treatment against obesity.
* They are receiving supraphysiologic hydrocortisone therapy (upper than 30 mg/jour).
* Their GH status change during the course of the study.
* Exenatide is contraindicated.
* Psychological and/or medical problems that would create difficulties for the patient to comply with the study protocol are present.
The Effect of Different Emergency Medical Systems on the Prognosis of Traumatic Brain Injury - a Prospective Study

The Aim of the Study is to Measure the Effect of Finnish Physician-staffed EMS Unit Treatment Methods on Traumatic Brain Injury (TBI) Patient Prognosis.

Physician-staffed HEMS unit was implemented to the EMS 2011. The aim of this study is to compare the results against a historical database to see if the implementation of a HEMS unit will improve the prognosis of TBI patients.

A Secondary Aim is to Identify Out-of-hospital Treatment Factors That Can be Influenced by Education and Protocols.

Eligibility Criteria:
Inclusion Criteria:

* TBI with CGS \< 9 or unconsciousness verified by an on-call neurosurgeon during admission to the hospital.

Exclusion Criteria:

* Multiple trauma
Injured Spinal Cord Pressure Evaluation

About a thousand people a year in the United Kingdom survive a spinal cord injury but are left paralysed or wheelchair-bound. The annual cost of care for spinal cord injury victims is more than half a billion pounds. We propose that after spinal cord injury, cord pressure at the injury site rises, damaging the spinal cord further by secondary ischaemia. The value of measuring and reducing cord pressure after spinal cord injury is unknown.

The injured spinal cord is compressed by bone malalignment and cord swelling. Current management involves realigning and fixing the bony fragments using metal screws, rods and plates. We hypothesise that: 1. Bony realignment alone does not adequately decompress the swollen cord, which remains compressed against the surrounding dura. 2. That duraplasty reduces intra spinal pressure more effectively than bone realignment alone. 3. Localised hypothermia reduces intra spinal pressure and improves metabolism.

We will develop a novel method to measure cord pressure and metabolism at the injury site after spinal cord injury and determine whether the cord pressure rises, for how long, and with what impact on spinal cord metabolism.

This is a pilot study to find out whether spinal cord pressure and metabolism can be measured after spinal cord injury and whether they are effected by treatment choices. We will examine if spinal cord perfusion pressure correlates with clinical outcomes.


Eligibility Criteria:
Inclusion Criteria:

Diagnosis of traumatic spinal cord injury American Spinal Injuries Association grade A-C spinal cord injury Presents within 72hrs of injury Capacity to consent for study

Exclusion Criteria:

Concurrent major co-morbidity likely to influence outcome Other major concurrent injury likely to influence outcome
Sepsis Prediction by Monocyte Distribution Width and Procalcitonin

The mortality rate of sepsis remains as high as 30 to 40%. Early diagnosis and treatment of patients with sepsis reduce mortality significantly. The most commonly used biomarkers in clinical practice are C-reactive protein (CRP) and procalcitonin (PCT). In terms of exploring new diagnostic tools of sepsis, monocyte distribution width (MDW) was first reported in 2017. It was reported as part of the white blood cell (WBC) differential count. MDW greater than 20 and abnormal WBC count together were reported to provide a satisfactory accuracy. The area under curve (AUC) in predicting sepsis-2 is 0.852. It was proposed as a novel diagnostic tool of sepsis in the emergency setting. Nonetheless, the performance of MDW compared with the conventional biomarkers remained unknown. The aim of this study was to compare the diagnostic accuracy of MDW and PCT on sepsis in the emergency department.


Eligibility Criteria:
Subject Inclusion Criteria

* Adult ≥20 years) subjects presenting to the ED with the chief complaints of fever, altered consciousness, hypotension, and dyspnea. CBC with differential testing performed, at presentation as part of their standard medical care.
* Subjects who have signed Informed Consent.

Subject Exclusion Criteria

* Previously enrolled in this study (i.e. subjects may not be enrolled more than once in this study)
* Subjects discharged from the ED \<72 hours
* Pregnant women
* Subjects not able to understand or sign Informed Consent
Ultrasound Guidance in Nerve Block Anaesthesia

Nerve block anaesthesia is wildly practised in France, avoiding general anaesthesia in a number of cases and producing excellent post-operative analgesia in trauma and orthopaedic surgeries. Even realised by experimented anaesthetists, 5-15% of failures and rare complications (such as vascular puncture, paresthesia, systemic local anaesthetic toxicity, epidural and spinal anaesthesia, neuropathy) are noticed. The aim of the study is the evaluation of an ultrasound-guidance technique in the four predetermined blocks and the incidence of their complications.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years and greater, scheduled for one of these blocks: interscalene, humeral, parasacral or lumbar blocks, for trauma or orthopaedic surgeries, who have consented to the study and are with social insurance registration

Exclusion Criteria:

* Block's contraindications, treatment by verapamil or flecainide
Metabolic Effects of Androgenicity in Aging Men and Women

The goal of this research study is to study the effect of testosterone or estrogen on blood sugar control and fat metabolism. Changes in hormone levels with age may affect risk factors for heart disease such as diabetes. Diabetes is a glandular condition associated with lack of the hormone insulin or an insensitivity to it resulting in problems with blood sugar control and fat metabolism. The effect of commonly used hormonal supplements such as testosterone by older adults on insulin and body composition is not well understood. In this study, the role of testosterone and estrogen on your ability to control blood sugar and your body composition will be assessed.

The investigators plan to study 60 subjects. All of these subjects will be healthy older men between the ages of 60-85 years old who are not on testosterone therapy. Subjects that are screened who have any clinically significant abnormalities detected on their screening physical exam or laboratory testing (e.g. Prostate Specific Antigen \> 4), who have a history of prostate cancer, polycythemia, or who cannot take testosterone will not be included.

If a subject is eligible to participate after initial screening, that subject will take medications to adjust their hormone levels and have tests performed that measure insulin sensitivity and adiposity before and after these hormone medications. The outcomes that will be measured are: 1) insulin sensitivity, 2) hormone levels (total and free testosterone levels, sex hormone-binding globulin levels) and 3) body composition and abdominal adiposity.


Eligibility Criteria:
Inclusion Criteria:

* males age 60-85 years
* non-diabetic fasting glucose and 2-hour oral glucose tolerance test (OGTT)
* overall good general medical health and signed informed consent
* willing to travel to West Los Angeles VA and University of California, Los Angeles in Los Angeles, California

Exclusion Criteria:

* any clinically significant abnormalities detected on screening physical exam or laboratory testing (e.g. prostate specific antigen \> 4)
* or other symptom or history of a significant underlying medical or psychiatric illness
* BMI \< 20 or \> 40
* subjects already on testosterone therapy or medications that might influence glucose regulation or hormone levels
* subjects with a history of deep venous thromboses, pulmonary embolism, breast cancer, prostate cancer, polycythemia or other contraindications to estrogen or testosterone
A Study of Felzartamab in Participants With Lupus Nephritis

The goal of this clinical trial is to evaluate the safety and tolerability of felzartamab plus standard of care in participants with refractory Lupus Nephritis (LN).

Study Sponsor, originally HI-Bio, Inc., is now HI-Bio, A Biogen Company.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of Systemic Lupus Erythematosus (SLE) according to the 2019 European League Against Rheumatism (EULAR)/ American College of Rheumatology (ACR) criteria
* Diagnosis of International Society of Nephrology/ Renal Pathology Society (ISN/RPS) 2003 Class III or IV LN as evidenced by renal biopsy performed within 1 year prior to or during screening, either with or without the presence of Class V LN
* Proteinuria (urine protein to creatinine ratio) \> 1.0 gram per gram (g/g), based on 24-hour urine collection during screening
* eGFR ≥ 45 milliliter/minute/1.73 square meters (mL/min/1.73 m\^2) (as calculated by the Chronic Kidney Disease Epidemiology Collaboration formula)
* History of inadequate response, for lack of efficacy or intolerance, to at least a three-month course of one standard of care treatment for lupus nephritis, as determined by the treating physician

Exclusion Criteria:

* Presence of rapidly progressive glomerulonephritis, as defined by at least one of the following: crescent formation in \> 50% of glomeruli on renal biopsy, sustained doubling of serum creatinine within 12 weeks of screening, or the investigator's opinion that the participant has rapidly progressive glomerulonephritis
* Greater than 50% of glomeruli with sclerosis on renal biopsy
* Currently requiring hemodialysis or peritoneal dialysis or expected to require dialysis during the study treatment period
* A previous kidney transplant or other organ transplant, or planned transplant within study treatment period

Other protocol-defined inclusion/exclusion criteria may apply
Relationship Between Oral DMT Burden and Adherence in MS

STATURE is a prospective observational six-arm translation multi-site study that will run for approx. 4.5 years. The primary aim is to measure treatment burden and its relationship to medication adherence across six self-administered oral disease-modifying therapies (cladribine, dimethyl fumarate, fingolimod, teriflunomide, ozanimod, and diroximel fumarate) in multiple sclerosis (MS). The information gained will assist prescribing decision-making; accounting for medication burden at a patient level and potential implications on medication adherence and persistence, thus minimising primary and secondary healthcare costs. Three-hundred and twenty-three individuals with MS will be recruited into the study. Patient-reported outcome measures will be administered via Qualtrics, a secure online data collection tool. Medicare and pharmaceutical benefits scheme (PBS) data will also be collected.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or older.
* A confirmed diagnosis of multiple sclerosis.
* Commencement (switching or newly prescribed) of one of the 6 following DMTs within the previous 2-months: cladribine, dimethyl fumarate, fingolimod, teriflunomide, ozanimod, diroximel fumarate.
* Able to read and write in English.
* Access to an internet connection and computer facilities, required to complete assessments.

Exclusion Criteria:

* Use of any other DMT than cladribine, dimethyl fumarate, fingolimod, teriflunomide, ozanimod, diroximel fumarate.
* Comorbid neurological condition.
* Severe cognitive or psychological dysfunction deemed to interfere with the person's ability to undertake study requirements, as determined by their MS clinic treatment team (neurologist; MS nurse).
Validation of a Tool for Assessing Gambling Problems Related to the Practice of Poker: the Copenhagen Poker Screen (CHAPS)

If the addiction to games of chance and gambling is a disease of increasing knowledge, the emergence of poker rout evaluation procedures, prevention and treatment usually offered to players in need. In the case of poker, which unlike other games has a real part to address and which damages are expressed differently, the evaluation can not be done identically to other games. This problem has often been emphasized in the literature, in particular the lack of specific tools for the identification of poker gambling problems. Thus, the fact of developing a specific evaluation tool could allow poker to take into account the specificity of poker among other games. This would be part of the evaluation complement batteries currently available to players in general by offering a specific tool, and secondly to allow the assessment of the aspects of the problems often absent for other games . The goal here is to develop and validate a specific tool detection of problem gambling in the particular context of poker.


Eligibility Criteria:
Inclusion Criteria:

* All subjects who had a practice of poker over the past 12 months

Exclusion Criteria:

* Participants who have already completed the survey (on the basis of their declaration)
Turkish Validation of the Adult Nutrition Literacy Tool

This study evaluated the validity and reliability of the Food and Nutrition Literacy Assessment Tool (FNLAT) in a sample of 849 Turkish adults. Reliability was tested using Cronbach's alpha, test-retest, and Pearson correlation, while construct validity was analyzed via factor analysis. Data were processed with SPSS and AMOS software.

Aim: The aim of this study is to evaluate the validity and reliability of the Food and Nutrition Literacy Assessment Tool in Turkey.

Subject and Methods: The study included 849 individuals aged 19-64 years (316 males, 563 females). A questionnaire containing socio-demographic characteristics and the " Food and Nutrition Literacy Assessment Tool (FNLAT)" and " General Nutrition Knowledge Questionnaire (GNKQ)" were used as data collection tools. Test-retest was performed on 60 individuals at 3-week intervals. Cronbach's alpha, test-retest, and Pearson correlation analyses were conducted to assess the reliability of the scale. The construct validity of the scale was determined using explanatory factor analysis. The data were analyzed using the SPSS (Statistical Package for Social Sciences) for Windows 25.0 and AMOS 21 programs.

Eligibility Criteria:
Inclusion Criteria:

* People aged 19 to 64 years

Exclusion Criteria:

* Individuals diagnosed with psychiatric or neurological diseases
* Individuals with alcohol or drug addiction.
Low-dose Digital Radiographs in the Idiopathic Scoliosis

The aim of the study is to evaluate the intraobserver repeatability and the interobserver reproducibility of low-dose radiographs with a HELIOS DRF (CAT) imaging system in patients with idiopathic scoliosis.

The 80% of scoliosis is idiopathic and begins mostly in adolescence (10-20 years).

The young patients need to undergo several radiographic controls for a correct therapeutic balance. However, the repeated radiation exposures is associated with a greater risk of carcinogenesis even if reduced with a digital imaging technique.

The aim of this study is to evaluate the intraobserver repeatability and the interobserver reproducibility of low-dose radiographs with a HELIOS DRF (CAT) imaging system in patients with idiopathic scoliosis.

Eligibility Criteria:
Inclusion Criteria:

* patients with suspected or known idiopathic scoliosis
* patients able to maintain orthostasis without medical devices
* patients from 9 to 20 years old

Exclusion Criteria:

* patients with known congenital, syndromic, neurological scoliosis
* patients not able to maintain orthostasis
* obese patients
* low back pain or known tumor pathology
* patients with vertebral arthrodesis
* patients younger than 9 years old, or older than 20 years old
Paracervical Block During II-trimester Abortion

Paracervical blockage can reduce severe pain during second trimester induced medical abortion.


Eligibility Criteria:
Inclusion Criteria:

* Women who request second trimester medical abortion (13-22 weeks gestation according to ultrasound)
* 18 years of age or older
* able to understand and communicate in Swedish
* able to understand the study related information and willing to give her
* informed consent to participation in the study

Exclusion Criteria:

* Known allergy to bupivakain or related substances
A Study of a Developmental,Individual-Difference,Relationship-Bases/Floortime Intervention for Children With Autistic

Thirty eight autistic spectrum disorder children age 2-6 years recruited into the study. The new treatment intervention is based on the DIR Model. Parents will be coached at the start and then every 3-4 months for 1 year. Outcome will be measured at the first session and at the end of the study using Functional Emotional Assessment Scale and Childhood Autism Rating Scales, Functional Emotional Level, and parent satisfaction rating.

Hypothesis of the study: Children who get additional treatment of DIR/floortime show much improvement in climbing the developmental "ladder" and declining in the autistic behaviors.


Eligibility Criteria:
Inclusion Criteria:

* clinical criteria for Autistic Disorders according to DSM IV
* child is 2 - 6 years of age

Exclusion Criteria:

* children with additional medical diagnosis (e.g., genetic syndromes, diagnosed hearing impairment, diagnosed visual impairment or seizures)
* children who are geographically inaccessible for follow-up visits
* their parents are not literate or known chronic psychiatric or physical illness in the parents
Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts

Prospectively analyze the use of 3D subtraction CAD/CAM in the operating room environment. Study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants. The rationale is to complete a pilot study of the technology with a small number of designs. Each implant will be commonly used, in the public domain, and recreated by the CAD/CAM software.

Conventional middle ear prosthetic prosthetics, including total ossicular replacement prostheses (TORPs) and partial ossicular replacement prostheses (PORPs) are expensive, require large inventories for otologic surgery services, and carry the risk of extrusion or rejection. Autologous bone and cartilage can be used for many of these applications, but it requires expensive operating room time for carving to the appropriate shape and size.

The above considerations led to the concept of subtractive 3D CAD/CAM (computer assisted design/computer assisted manufacture) to produce accurate bone and cartilage autografts on demand in the operating room. Such a technology is hypothesized to save money by reducing operating room time, and reducing the need for expensive inventories of various shapes, sizes, and types of prosthetic devices. Since autologous materials are hypothesized to be less likely to extrude or cause other problems such as infection, this could also reduce costs.

Eligibility Criteria:
Inclusion Criteria:

* at least 18 years of age with middle ear disease requiring surgical ossicular reconstruction

Exclusion Criteria:

* congenital anomalies