cyrilzakka/clinical-trials huggingface dataset:
F-18-OMFD-PET for Radiotherapy Treatment Planning and Evaluation of Early Therapy Response

The purpose of this study is to monitor the amino acid uptake of brain tumors, before and during radiotherapy, with positron emission tomography.


Eligibility Criteria:
Inclusion Criteria:

* Brain tumor
* Radiation therapy indicated
* Written consent

Exclusion Criteria:

* Pregnancy
* Mental impairment
* Drug/alcohol abuse
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients

China's aging population is causing an increase in the number of senior persons undergoing surgery. More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients.

Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist that works by inhibiting norepinephrine releasing renaline, which reduces inflammation and thus plays a protective role in the central nervous system. DEX has the potential to prevent and treat postoperative anxiety and depression in elderly patients undergoing non-cardiac surgery.

Further exploration of evidence for evidence-based medicine is needed. Based on the above research background, this hypothesis is proposed: in elderly patients undergoing noncardiac surgery, intraoperative DEX is associated with a reduction in short-term postoperative mental disorders and a reduction in long-term postoperative mortality.

Studies have suggested that continuous infusion of low-dose DEX during the night after surgery can significantly reduce the incidence of delirium, alleviate pain, and improve subjective sleep quality.

However, it is currently unclear whether choosing DEX during anesthesia has any impact on mortality and mental disorders in older patients undergoing non-cardiac surgery.

Therefore, we utilized prospective research data from 7 centers in China to explore the relationship between intraoperative use of DEX and postoperative 12-month mortality and mental disorders. Propensity score-matching (PSM) and Inverse probability of treatment weighting (IPTW) were conducted, and subgroup analyses were also applied.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥65 years old, regardless of gender
2. Patients undergoing general anaesthesia (combined sedation or intravenous general anaesthesia)
3. ASA level 1-3
4. Patients undergoing elective non-cardiac surgery, non-neurosurgery

Exclusion Criteria:

1. More than 20% missing data for covariates;
2. Postoperative admission to the intensive care unit (ICU) or death during follow-up;
3. Preoperative history of severe sleep disorder and taking related medication;
4. Have a history of severe anxiety or depression prior to surgery and taking relevant medication;
5. Severe hearing, speech and cognitive impairments that preclude access to follow-up visits
Transcutaneous Diaphragm Electrical Stimulation in Critically Ill Patients

This study evaluates the effect of a transcutaneous electrical stimulation in critically ill patients compared to a sham electrical stimulation to decrease the incidence of diaphragm dysfunction before mechanical ventilation weaning.


Eligibility Criteria:
Inclusion Criteria:

* Patients intubated and ventilated for at least 24 h
* Patients who were expected to have at least 48h after inclusion

Exclusion Criteria:

* Patient with pacemaker
* Patient under neuro muscular blocker
* Patient post thoracic or abdominal surgery
* Patient with BMI more than 35 kg/m²
* Patient with degenerative neurological pathology
* Patient with cutaneous lesion may be interfered with probes
* Patient with chronic loss of autonomy
* Patient hospitalized more than 72 hours before ICU admission
* Patient with severe chronic obstructive pulmonary disease (FEV1 \< 30%)
* Patient with decision to withhold life-sustaining treatment
Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption

Oxymetazoline is an α-adrenergic agonist that is commonly used as a topical sympathomimetic agent in over-the-counter decongestant sprays. It is used extensively at Nationwide Children's Hospital for surgical procedures to produce vasoconstriction and reduce bleeding. Although there is generally limited vascular absorption, when administered in larger doses, uptake of oxymetazoline can lead to significant systemic hemodynamic effects. The NCH anesthesia department recently reported a case of oxymetazoline induced postoperative hypertension in a three-year-old child following inferior turbinate reduction and adenoidectomy. Current practice at NCH is to soak pledgets with full strength oxymetazoline and insert a varying number of pledgets during surgical procedures or instill oxymetazoline drops into the nose prior to nasotracheal intubation. There is no pediatric data regarding the method of administration and the absorption of oxymetazoline or the dose-response relationship of oxymetazoline serum levels on blood pressure and heart rate. These studies would be the first to determine safe and appropriate doses of oxymetazoline in the pediatric population.


Eligibility Criteria:
Inclusion Criteria:

* Patients ages 2 through 12 yrs.
* Scheduled for: operative dentistry, functional endoscopic sinus surgery, or turbinate reduction (with or without tonsillectomy and/or adenoidectomy).

Exclusion Criteria:

* Treatment with oral decongestants or antihistamines within 24 hours of surgery.
* Taking anticoagulants.
* History of nasal trauma.
* History of epistaxis (nose bleeds).
* History of hypertension or cardiac disease.
* Allergy to oxymetazoline.
Prevalence and Main Features of Chronic Refractory Cough.

Cough is among the most common causes of medical consultation in primary care.\[1\] Chronic cough, arbitrarily defined as symptom persisting more than 8 weeks, has been variably reported in different settings and geographical area, with an overall prevalence of 10-20% in the general population, that increases up to 40-50% in pneumology specialist clinics.\[2,3\] While acute cough is generally caused by the common cold and typically lasts one to three weeks, chronic persisting cough can underlie more serious disease processes. Moreover, it can impair quality of life,\[4\] possibly leading to tiredness, urinary incontinence, and eventually syncope. It also has psychosocial effects such as embarrassment and negative impact on social interactions.

A careful clinical history may provide important diagnostic clues that allow therapeutic trials without the need of further investigations.\[5\] Smoking history, medication list and presence and character of sputum should be carefully detailed. Identification of the causes of productive cough is generally straightforward and strategies for intervention and treatment are well defined.\[5\] Conversely, chronic dry or poorly productive cough represents a greater diagnostic challenge. Several studies have shown that in nonsmokers with normal chest radiography who are not taking ACE-inhibitor, chronic cough is usually due to asthma, rhinosinusitis or gastro-esophageal reflux (GER).\[6\] Many dedicated algorithms have been identified to guide the diagnostic phase and to sequentially coordinate the execution of further diagnostic deepening and/or empirical treatments, based on cost-effectiveness principles.\[5,7-9\] Among these, the European Respiratory Society (ERS) recommendations\[5\] are widely applied in clinical practice and broadly parallel those released by the American College of Chest Physicians\[7\]. This notwithstanding, a proportion of cases do not reach a definite diagnosis and resolutive treatment\[7\]. This condition is termed chronic refractory cough (CRC), chronic idiopathic cough, or unexplained chronic cough.\[7,10\] It can be diagnosed when patients have no identified causes of chronic cough (unexplained or idiopathic chronic cough) or when the cough persists after investigation and treatment of cough-related conditions. Because patients with unexplained chronic cough often receive specific therapies, such as inhaled corticosteroids or proton pump inhibitors, they can also be classified as having CRC.

The real prevalence of CRC is not well-know and many cases of CRC may be actually misdiagnoses due an incomplete application of recommended work-up. In the present study we aim to estimate the prevalence of chronic cough in different care settings, together with the prevalence of CRC according to a systematic and integrated approach. The careful application of the recommendation defined by ERS guidelines will allow to detect truly refractory cases of chronic cough.


Eligibility Criteria:
Inclusion Criteria:

* complaining chronic cough (lasting more than 8 weeks)

Exclusion Criteria:

* Unwilling to participate
Comparison of Safety and Efficacy of the Combination Product QVA149A Against the Concurrent Administration of the Individual Components, QAB149 and NVA237, in Patients With Chronic Obstructive Pulmonary Disease (COPD)

The study assessed the safety and efficacy of the fixed combination product QVA149 versus the component products QAB149 and NVA237, administered concurrently, in patients that have moderate to severe chronic obstructive pulmonary disease (COPD).

The study assessed the safety and efficacy of the fixed combination product QVA149 versus the component products QAB149 and NVA237, administered concurrently, in patients that have moderate to severe chronic obstructive pulmonary disease (COPD).

Eligibility Criteria:
Inclusion Criteria:

* Male or female adults aged ≥ 40 yrs
* Smoking history of at least 10 pack years
* Diagnosis of COPD (moderate to severe as classified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Guidelines, 2010)
* Post-bronchodilator FEV1 \< 80% and ≥ 30% of the predicted normal value and post-bronchodilator FEV1/FVC (forced vital capacity) \< 70%

Exclusion Criteria:

* Patients who have had a respiratory tract infection within 4 weeks prior to Visit 1
* Patients with concomitant pulmonary disease
* Patients with a history of asthma
* Any patient with lung cancer or a history of lung cancer
* Patients with a history of certain cardiovascular co-morbid conditions
* Patients with a known history and diagnosis of alpha-1 antitrypsin deficiency
* Patients in the active phase of a supervised pulmonary rehabilitation program
* Patients contraindicated for inhaled anticholinergic agents and β2 agonists

Other protocol-defined inclusion/exclusion criteria may apply
Correlates of Physical Activity With Quality of Life in College Women of Manipal University

To find out the relationship between physical activity and

* self-esteem,
* sleep quality,
* anxiety \& depression,
* body fat percentage,
* quality of life, in college females

* After receiving approval from the Institutional Research Committee and Institutional Ethical Committee clearance.
* Advertisement of the research project will be done via the Head of Department of each faculty of the university
* Subjects will be recruited on a voluntary basis and a written informed consent will be obtained after the research idea is explained.
* Demographics of each participant will be obtained
* Each of the following questionnaires will be administered:

Depression, Anxiety and Stress Scale (DASS-21) Rosenberg Self-Esteem Scale Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form (Q-LES-Q-SF) Pittsburgh Sleep Quality Index (PSQI) International Physical Activity Questionnaire-Long Form (IPAQ)

Eligibility Criteria:
Inclusion Criteria:

* Female gender
* age group 18-25
* Indian ethnicity

Exclusion Criteria:

* Known cardio-respiratory symptoms and musculoskeletal disorders curtailing form physical activity in the last 3 months, known thyroid dysfunction, known anxiety-depression disorders, recent surgery (last 3months), polycystic ovary disease (PCOD), polycystic ovary syndrome (PCOS) \& pregnancy.
Repetitive Arm Training + FES on Upper Extremity Motor Recovery in Sub-acute Stroke Survivors

Rehabilitation restores functions and reduces disabilities due to diseases sequelae. The relationship between intensity of rehabilitation and clinical outcomes, recently emphasized, has generated a great interest for technological high-intensity interventions. However, their effects compared to traditional interventions as well the involved biological mechanisms remain uncertain. The present Strategic Program aims to predict the treatment efficacy in specific rehabilitation profiles, to improve the use of "targeted" therapies and the individual management of patients affected by stroke and to transfer these findings into rehabilitative strategies.

Primary endpoint: Fugl-Meyer Upper Extremity (FM-UE) Secondary endpoints: Box and Block Test (BBT), Modified Ashworth Scale (MAS); motor cortex excitability (TMS); Electromyography analysis of muscle activation patterns during upper extremity movements; measurements of cerebral perfusion (NIRS); circulating biomarkers (see Figure 3 and Table 1). Overall assessments will be performed pre-, mid-, post-treatment and at 6-months follow-up.

Eligibility Criteria:
Inclusion criteria:

* males and females, age 18 to 79 years
* diagnosis of first, single unilateral ischemic stroke verified by brain imaging \< 8 weeks
* upper limb motor function defined by an FM-UE score \> 11 and \<55

Exclusion criteria:

* medical conditions likely to interfere with the ability to safely complete the study protocol
* impaired cognitive functioning: score less than 24 on the Mini Mental Status Examination (MMSE)
* severe upper-limb pain, referred as \> 7 at Visual Analog Scale (VAS)
* history of seizures or epilepsy
Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphene Citrate to Improve Pregnancy Rate in PCO Patients

To evaluate the effect of oral Phytoestrogen or Isosorbid mononitrate or N-acetyl cysteine as an adjuvant to clomiphene citrate on induction of ovulation and pregnancy outcomes in patients with PCOS. In this three-arm open RCT, 240 PCOS infertile women were randomly divided to 3 groups for induction of ovulation. Group A, \[PE group, n= 80\] patients received CC 100mg/d plus oral Phytoestrogen120 mg/ day and patients in Group B, \[ISMN group, n=80\] received CC 100 mg/d plus 20 mg Isosorbid mononitrate and Group C, \[NAC group, n=80\] patients received CC 100 mg/d plus NAC 1200 mg/day.


Eligibility Criteria:
Inclusion Criteria:

1. All patients have PCOS.
2. All patients received CC 100 mg/day for 5 days starting from day 5 with successful ovulation as documented by folliculometry and midluteal serum progesterone with no pregnancy achieved.
3. All patients have patent fallopian tubes by Hysterosalpingography.
4. Their husbands have normal semen analysis according to the modified criteria of WHO.
5. All patients have normal serum prolactin and thyroid profile.
6. Any patient having vaginitis was treated before starting induction.

Exclusion Criteria:

1. Other causes of infertility than anovulation.
2. Diabetes or other endocrinological disorders.
3. Age \> 40 years.
4. Smoking.
5. Alcohol use.
6. Presence of ovarian cyst \>2cm on the second day of the cycle.
7. Patients who have received gonadotrophins in the preceeding 6 months.
8. Patients who have done unilateral or bilateral ovarian drilling.
9. Allergy to PE, NO donors or NAC
Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease

The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated with a precipitating event (hepatotoxic: superimposed hepatitis viral infection, drug-induced liver injury, hepatotoxins, or excessive alcohol consumption; extra hepatic: variceal bleeding or sepsis), leading to severe deterioration in clinical status with jaundice and hepatic encephalopathy and/or HRS. Following this concept, several proposals for the diagnostic criteria of ACLF have been suggested.

There may be regional differences in etiology, pathogenesis, and natural course of ACLF, which may in turn influence the overall outcome of this syndrome. So, proper diagnosis of ACLF and its precipitating factors in our locality enable us for proper management of these cases and dealing with these precipitating factors to be avoided later on in patients with liver cirrhosis

Aim of the work:

To identify the pattern of acute on chronic liver cell failure (ACLF) within 28 days including prevalence, percipitating factors, and outcome.

Patients and methods

Type of the study: Prospective hospital based study

Site of the study: Tropical Medicine and Gastroenterology Department, Al-Rajhi University Hospital, Assiut University Hospitals, Assiut, Egypt. Written consent will be obtained from all the participants or their relatives before enrollment.

Eligibility Criteria:
Inclusion Criteria:

* Adult Patients with HCV related CLD based on clinical, biochemical and imaging evidence., with or without prior decompensation.
* Patients diagnosed to have ACLIF at any grade (1-3)

Exclusion Criteria:

* Acute liver failure without evidence of chronic liver disease.
* Other etiology of chronic liver disease
* Patients diagnosed with no ACLIF No ACLF
* This category includes patients who either:

  * Do not have any organ failure
  * Have a single organ failure that does not involve the kidney with a serum creatinine level of \<1.5 mg per dl and no hepatic encephalopathy
  * Have a single brain failure with a serum creatinine level of \<1.5 mg per dl
* Patients refuse to participate.
Systematically Adapted Delivery of the Family Check-Up

Early childhood disruptive behavior problems lead to significant costs to families and society, but can be reduced with behavioral parent training interventions. To increase the public health impact of these interventions, their feasibility, accessibility, and acceptability in high-need, underserved communities must be ensured. This pilot project will systematically adapt and pilot-test the delivery model of an existing effective parent training intervention for implementation in rural Appalachia, a region with many documented health disparities, high levels of poverty, and shortages of mental health providers. Community health workers in 5 rural Appalachian counties will be trained to deliver a behavioral parent training intervention. Each worker will deliver the intervention to 4 parent-child dyads.


Eligibility Criteria:
Inclusion Criteria:

* Parents: aged 18+ years, custodial guardian of child, can speak/read/understand English
* Children: ages 3-5 years, lives full time in custodial guardian's home
* Community health workers: aged 18+ years, currently employed at a partnering health department, able to speak/read/understand English

Exclusion Criteria:

* Parents: has already accessed behavioral health services for the child, reports suicidal ideation or intent to harm self or others, participated in formative research for this study
* Children: diagnosed with a severe developmental condition (i.e., significant developmental delay, autism, debilitating neurological condition)
* Community health workers: none
The Effect of Aerobic Exercise in Overweight and Obese Women

Study design The study was designed as a prospective controlled randomized trial. Participants were randomly assigned to one of two groups. In the experimental group, participants (n = 17) received 8-week aerobic exercise intervention without nutrition modifications. In the control group, participants (n = 16) did not undergo any intervention and were instructed to maintain their regular physical activity and diet regime for 8 weeks.

Experimental measurements: Anthropometric measurements, Measurement of BDNF, Cardiac autonomic responses, Measurement of aerobic fitness, Measurement of cognitive functions.


Eligibility Criteria:
Inclusion Criteria:

1. obese women (BMI) \> 25 kg/m2;
2. exhibiting weight stability (body weight change \< 2 kg) for at least 2 months prior to enrollment;
3. with a sedentary lifestyle (regular exercise \< 1 h/week);
4. had no medical condition that would affect study results and limit physical activity;
5. not undergoing lactation;
6. who were not pregnant or postmenopausal.
Changes in Vitreous Temperature During Phacoemulsification

Temperature in the vitreous cavity decreases during vitrectomy, and the same effect is seen during an uneventful phaco surgery. Significant changes occur between the baseline temperature and after every step of the surgery.

A 23-gauge thermometer probe inserted prior to the beginning of the cataract surgery to measure the vitreous temperature at different stages of the procedure (capsulorrhexis, hydrodissection, phacomulsification, irrigation/aspiration and intraocular lens (IOL) implantation). Room temperature also registered during every step. At the end of the surgery, oral temperature will be measured.

Eligibility Criteria:
Inclusion Criteria:

* Patients from the Retina department that underwent phacoemulsification and vitrectomy

Exclusion Criteria:

* Posterior capsule rupture
Pyrotinib in Combination With Trastuzumab in Treatment-refractory, HER2-positive Metastatic Colorectal Cancar.

This clinical trial aims to evaluate the efficacy, safety of Pyrotinib in combination with trastuzumab in Treatment-refractory, HER2-positive Metastatic Colorectal Cancar.


Eligibility Criteria:
Inclusion Criteria:

Patients should be histologically diagnosed with metastatic colorectal cancer or postoperative recurrence; Patients with ALK mutation(including mutation, fusion, rearrangements ); Patients have measurable lesions; Patients are not available for targeted therapy or patients refuse to receive targeted therapy afer second-line treatment; Over 3 weeks after radiotherapy and the radiotherapy focus was not be measured; Age should be 18-25 years; Performance status should be 0-2; Life expectancy should be more than 12 weeks;

Exclusion Criteria:

Patients underwented major surgery or severe trauma within 4 weeks; Patients allergiced to experimental drugs; Patient ready to give birth or who is pregnant; Patients with brain metastases; Patients with chemotherapy contraindication; Patients could not tolerate chemotherapy; Patients have secondary primary tumor.