cyrilzakka/clinical-trials huggingface dataset:
Effectiveness of Intensive Smoking Cessation Interventions in Patients With Cancer

Smoking accounts for approximately 30% of total cancer deaths each year. Even though former studies show that persons with a cancer diagnosis are less likely to smoke than the general population up to 50% of people who smoke and have lung cancer do not stop smoking after their diagnosis or frequently relapse after smoking cessation. Continued smoking leads to increased all-cause mortality, increased cancer-specific mortality, and decreased quality of life. It is well-known that cancer patients are interested in smoking cessation therefore smoking cessation interventions play an important role in the management of people with cancer.

This study will evaluate the effectiveness of an intensive smoking cessation interventions on cancer patients in real life. The project provides new knowledge about smokers diagnosed with cancer.

This prospective register-based cohort study including smokers attending an intensive smoking cessation intervention (the Gold Standard Programme (GSP)) from 2006-2017 in Denmark. The GSP is a manualised, patient education programme taught by specially trained staff, including pharmacologic strategies.

Eligibility Criteria:
Inclusion Criteria:

* Smokers registered in the National Danish Smoking Cessation Database between January 2006 until May 2017

Exclusion Criteria:

* Entries referring to smokers attending more than one smoking cessation intervention (the latest entry will be used)
* Smokers younger than 18 years of age
* Smokers attending interventions other than the intensive Gold Standard Programme for smoking cessation (GSP)
* Smokers where the smoking cessation unit pre-decided not to follow up on their participants
* Smokers in the non-cancer group diagnosed with benign neoplasms, tumours of unknown etymology or non-melanoma skin cancer (ICD-10 diagnoses: D30.1-9; D32-33; D35.2-4; D41.1-9; D44.3-5; C44, C46.0)
OASIS: RetrOspective Analysis on EEGs for Identifying Seizure Susceptibility in paediatrIcs Using biomarkerS

The goal of this retrospective study is to validate a set of computational biomarkers (BioEP) for seizure susceptibility on retrospective routinely collected non-contributory EEGs in paediatric participants with epilepsy. The main objectives are:

Primary:

To validate a set of computational biomarkers (BioEP) for seizure susceptibility on retrospective routinely collected non-contributory EEGs in paediatric participants with epilepsy.

Secondary:

To examine whether the use of BioEP could support a more efficient patient pathway to diagnosis (thus adding economic value), by reducing time to final diagnosis and/or the number of clinical appointments needed


Eligibility Criteria:
Inclusion Criteria:

* ≥2-\<18 years age.
* Patients who have had a confirmed epilepsy diagnosis for ≥1+ year.
* Non contributary first EEG: including routine EEG, sleep EEG (natural, melatonin induced, sleep deprived), 24-hour ambulatory EEG.
* Patients who have been diagnosed with a self-limited and or focal epilepsy \[\*\] who have had a first non-contributary (no IEDS present, negative) outpatient EEG.
* Patients who have been diagnosed with idiopathic generalised epilepsy \[†\] who have had a first non-contributary (no IEDS present, negative) routine EEG.
* Neurodiverse patients with epilepsy can be included in the study \[‡\]
* Patients with epilepsy and co-morbidities can be included in the study (anxiety, mood disorders etc)
* Controls should be EEGs taken from patients who have been referred for a paroxysmal disorder, received an EEG as part of their diagnostic work up and subsequently received an alternate diagnosis. Epilepsy should have been excluded from their differential diagnosis and the alternate diagnosis should have remained stable for ≥1+ year.

Exclusion Criteria:

* Developmental and/or epileptic encephalopathies \[§\]
* Patients with global development delay of unknown origin.
* Patients with profound and multiple intellectual disabilities
* Participants with a known hepatic/renal encephalopathy.
* Patient diagnosed with possible NEAD and epilepsy (dual diagnosis).
* Participants taking part in another Clinical Trial of an Investigational Medicinal Product (CTIMP) (qualitative/observational studies are acceptable).
* Patients with any breaches of skull (plates, burr holes, shrapnel).
Comparison of Safety and Efficiency of 20w and 30w Holmium Laser Device in Management of 2-3 cm Diameter Kidney Stones With Retrograde Intrarenal Surgery

To compare safety and efficiency of 20w 30w holmium laser device in treatment of 2-3 cm diameter kidney stones with Retrograde Intrarenal Surgery (RIRS).


Eligibility Criteria:
Inclusion Criteria:

* patients who have 2-3 cm kidney stones
* patients who are between 18-90 years old

Exclusion Criteria:

* patients who have congenital urogenital abnormalities
* patients who have previous surgery history for urinary stones
Absorbable Screws to Treat Anterior-Superior Iliac Spine Avulsion Fractures

There is some debate over the best treatment for anterior-superior iliac spine (ASIS) avulsion fractures although conservative treatment can be applied when there are no neurological symptoms. Open reduction and internal fixation can be performed for dislocations exceeding 1.5 cm, or in patients requiring a short period of convalescence, although a second operation is subsequently required to extract osteosynthetic material. In this paper, we introduce the use of absorbable screws as a new fixation material for the second round of surgery.

To investigate the feasibility of absorbable screws as a new fixation material for the treatment of ASIS avulsion fractures in children and adolescents.The investigator plan to retrospectively analyzed 59 patients diagnosed with ASIS avulsion fractures in our hospital between Jan 2009 and Dec 2016. These patients were divided into two groups: group A (conservative group) and group B (absorbable screws). Group A received conservative therapy involving bed rest with the affected lower extremity positioned with the hip and knee in flexion to ensure minimal tension of the muscles attached to the ASIS avulsion fracture. Group B received open reduction and internal fixation with fixation by absorbable screws. Six weeks and three months after treatment, all patients were assessed for range of motion (ROM) and by X-ray as they returned to activity. One week after treatment, the American Academy of Orthopaedic Surgeons (AAOS) lower limb and hip score was used to evaluate hip function; the same scores were also determined during follow-up at 1, 3, 6 and 12 months postoperatively.

Eligibility Criteria:
Inclusion Criteria:

* avulsion fracture of the ASIS
* new fractures

Exclusion Criteria:

* old avulsion fractures
* delayed fractures
* multiple fractures.
Effect of Hot Footbath on the Sleep Quality

The research title is the effect of hot footbath on the sleep quality of patients with chronic schizophrenia. The research was a randomized controlled trial. The setting was the chronic inpatient wards at a psychiatric teaching hospital in Northern Taiwan. A total of 63 participants, 30 in the hot footbath group and 33 in the control group, were completed the study from November 2019 to June 2020. Participants were randomly allocated to the experimental group and the control group. Through this method, we explored whether the trial could effectively improve patients' sleep quality.

The research title is the effect of hot footbath on the sleep quality of patients with chronic schizophrenia. The research was a randomized controlled trial. The setting was the chronic inpatient wards at a psychiatric teaching hospital in Northern Taiwan. A total of 63 participants, 30 in the hot footbath group and 33 in the control group, were completed the study from November 2019 to June 2020. Participants were randomly allocated to the experimental group and the control group. The experimental group was given a hot footbath with a temperature of 41℃±1℃ for 20 minutes at about 1-2 hours before sleep, and this was repeated five times a week for four weeks; the control group was given routine care for four weeks. The CPSQI was used to collect the pre- and post-test data. Through this method, we explored whether the trial could effectively improve patients' sleep quality.

Eligibility Criteria:
Inclusion Criteria:

1. Clinical diagnosis of Schizophrenia Disease.
2. Having Schizophrenia at least two years.
3. Must have above 5 scores in the Pittsburgh Sleep Quality Index (CPSQI).

Exclusion Criteria:

1. Having the foot problems, including allergy, wound, swelling, pain, peripheral circulation, and any skeletal, muscular, or nervous lesions in the foot.
Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis

Evaluation of two treatment modalities in early potentially severe early arthritis ( Methotrexate alone or in combination with adalimumab)

Patients: early ( less than 6 months), active ( DAS\>5.2),potentially severe ( Leiden score\>6) Study design:12 months, prospective , randomized, open Study treatments: Methotrexate at a weekly dose of 0.3mg/kilo alone or in combination with adalimumab 40 mg every the other week Outcome measures: DAS over the 12 months

Eligibility Criteria:
Inclusion Criteria:

* Early Active Potentially severe arthritis

Exclusion Criteria:

* contra indication of methotrexate or anti TNF
Effect of Coconut Oil Application in Reducing Water Loss From Skin of Premature Babies in First Week of Life (TEWL)

The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness. Most preterm babies lose up to 13% of their weight as water loss from their skin during the first week of life. Many strategies have been utilized by neonatologists to decrease this water loss. Oil application on the skin can act as a non permeable barrier and can help in reducing water loss from the skin. Edible coconut oil, often used for traditional massage of babies by Indian communities, is culturally acceptable and Hence the investigators decided to undertake this study to objectively assess the reduction in water loss from skin after oil application


Eligibility Criteria:
Inclusion Criteria:

All preterm babies born at the study center with birth weight \< 1500gms were eligible for inclusion in the study.

Exclusion Criteria:

1. Babies with birth weight less than 750 gms at birth
2. Babies with major congenital malformations.
3. Babies with severe asphyxia, hydrops and shock.
4. Babies with congenital diseases of skin associated with skin breach or denudation of skin precluding oil application
5. Babies with preexisting skin infection such as multiple furuncles (2 or more skin areas - each limb, head, chest, abdomen and back are the individual areas that will be taken as one area
Mid-Term Natural Course Postoperative of Crowe Type III-IV Hip Dysplasia

Comparison of preoperative and postoperative mid-term course of patients with Crowe Type 3 and Type 4 hip dysplasia.

Crowe type 3 and type 4 patients who underwent shortened hip replacement surgery will be followed up for 2 years.

Patients will be called for routine outpatient controls at the 2nd week, 6th week, 3rd month, 6th month, 12th month, 24th month.

Patients will be referred to the physical therapy specialist for abduction strengthening and pelvis tilt corrective exercises starting from the 6th week.

Scoliosis and orthoroentgenography x-rays will be taken at the last control of the patients.

HHS, WOMAC hip score and SF-12 score will be obtained from the patients. Scores, lower extremity and spine angles will be evaluated after the last examinations performed at 12 and 24 months.

Eligibility Criteria:
Inclusion Criteria:

* Crowe type 3 and 4 patients over 18 years of age who had shortened hip replacement surgery

Exclusion Criteria:

* Crowe type 1 or 2 patients over 18 years of age who had shortened hip replacement surgery
* Patients who have previously operated on the contralateral hip
* Patients who underwent shortened hip replacement for a reason other than developmental dysplasia of the hip
Early Versus Delayed Laparoscopic Cholecystectomy For Acute Mild Biliary Pancreatitis: A Prospective Comparative Study

The goal of this observational study is to evaluate the outcomes of early versus delayed cholecystectomy following mild biliary pancreatitis in Nepalese patients.

This was a hospital-based prospective observational study performed at a tertiary academic center from September 2020 to August 2021.

Patients diagnosed with acute mild biliary pancreatitis according to the Revised Atlanta classification 2012 were enrolled from the Emergency/Outpatient Department. Detailed history taking and thorough general and systemic examinations were conducted. Eligible patients were informed about treatment options (early vs. delayed LC) and provided informed written consent. Randomization into "early" or "delayed" groups was performed, and detailed investigations were conducted. To avoid bias, randomization was accomplished by lottery method. In the early group, laparoscopic cholecystectomy was performed during the same admission, while delayed group patients underwent surgery after symptom resolution and readmission. Surgeries were performed under general anesthesia with standard laparoscopic techniques with surgeons of equivalent qualifications. Postoperative care included analgesics and antibiotics, with follow-up examinations and histopathological assessments conducted at specified intervals. Oral intake and pain management protocols were implemented postoperatively, with patients monitored for recovery and instructed to return to normal activities after staple removal. Patients were asked to complete a visual analog pain score (VAS) from 0 (no pain) to 10 (intolerable pain) on the seventh postoperative day.

Eligibility Criteria:
Inclusion Criteria:

* Patients (\>18 years of age) who presented with the diagnosis of acute mild biliary pancreatitis in our hospital were included after obtaining written consent

Exclusion Criteria:

* patients with severe sepsis, acute moderate and severe pancreatitis, immunocompromised conditions, biliary peritonitis, cholangitis, pregnancy, admission to the intensive care unit (ICU) or high dependency unit (HDU) and those who declined to provide consent.
Efficacy of Peripheral Magnetic Stimulation to Reduce Pain in Knee Osteoarthritis.

To investigate effects of repetitive peripheral magnetic stimulation (PMS) on pain reduction in knee osteoarthritis


Eligibility Criteria:
Inclusion Criteria:

* Primary knee osteoarthritis patients who have had knee pain for at least 6 months and age more than 50 years, had morning stiffness not more than 30 minutes or crepitation.
* Kellgren and Lawrence classification 2-4
* Visual analog scale of pain 4 or higher.

Exclusion Criteria:

* Patients with other musculoskeletal problems associated with knee joint
* Patient with history of physical therapy in past 1 month
* Patient with pacemaker, cochlear implant or cerebral shunt
* Patient with history of knee surgery
* Patient with neurological or other severe disease
* Patient with previous seizure.
Reducing Eco-anxiety Using Selfies

The purposes of this study are to test among adolescent viewers the utility of selfie (TikTok) short video-based interventions to:

1. Reduce ecological anxiety,
2. Increase ecological agency,
3. Compare two different types of messaging, and
4. Examine the role of viewer's gender and race as independent factors on the outcomes of interest.

Intervention videos will each be TikTok self-recorded videos (of 58-second duration) featuring the same underage professional (ages 16) acting as simulated participant. Video 1 ("Negative") will focus on impending ecological catastrophic outcomes; Video 2 ("Positive") will focus on the actions that youth will be able to take in preventing such outcomes; and Video 3 ("Neutral") will include content unrelated to ecological concerns.

We intend to assign \~1,000 individuals aged 14-18 in a randomized way, in equal proportions, and stratified by sex and race, to view one of the three TikTok videos: Positive, Negative, or Neutral.

Assessments will occur at baseline and post-intervention, and will include:

1. Demographics (baseline only),
2. Primary outcome:

   a. Climate Change Anxiety scale (13 items)
3. Secondary outcome:

   1. Climate Hope scale (11 items)
   2. Behavioral intentions (6 items; adapted from)29,
   3. Hopefulness and agency sliders (2 items), and
   4. Three words

Eligibility Criteria:
Inclusion Criteria:

* English-speaking
* Living in the US
* Ages 14 - 18

Exclusion Criteria:

* None
Inflammation in an Ultra Endurance Race

The aim of this study is to study the per and post-exertional variations of the pro and anti inflammatory markers during an ultra-endurance race in healthy volunteers.

Study per and post-exertional changes in proinflammatory biological (IL1, IL6, TNF alpha, HMG beta1 and CRP) and anti inflammatory parameters (IL4, IL10 and IL13, TGF beta, LPS, lipoproteins, lipids) during an ultra endurance race.

Eligibility Criteria:
Inclusion Criteria:

1. Male older than 18 years,
2. Completion of an ultra-endurance race (distance greater than 50 kilometers) during the 24 months preceding the race.
3. Affiliation or beneficiary of a social security.

Exclusion Criteria:

1. Age lower than 18 years,
2. Subjects with a medical history (pulmonary pathology, cardiac, hypertension) or with a significant chronic inflammatory disease observed during the inclusion visit (the day before the race).
3. Female.
Brain Machine Interface (BMI) in Subjects Living With Quadriplegia

In this study, investigators will show proof-of-concept that brain signals can be used in real-time, closed-loop mode to trigger stimulation for hand function. Subjects will undergo surgery to implant a unilateral subdural strip electrode (Resume II, Model 3587A) over the motor cortex. These electrodes implanted in the brain will enable bioelectrical data recording (sensing) from the brain to the implanted Activa PC+S. The cortical sensing data will be

1. either processed in the Activa PC+S; or
2. off-loaded via the Nexus D communication device (Medtronic) to a computer.


Eligibility Criteria:
Inclusion Criteria:

* AIS Grades A \& B
* Level of Injury C5 or C6
* Local Community dwelling
* Stable chronic injury
* Stable health status and upper extremities
* Completion of Clinical Protocol 01

Exclusion Criteria:

* Coagulopathy
* Anticoagulation
* Pregnancy
EBUS-TBNA vs Flex 19G EBUS-TBNA

Endobronchial ultrasound (EBUS) guided transbronchial needle aspiration (EBUS-TBNA) is an excellent tool for sampling enlarged mediastinal and hilar lymph nodes, but only provides needle aspirate samples which are often adequate for cytological examination only. More advanced histopathological and immunocytopathological assessment of tissue samples, which is particularly important in the diagnosis and staging of cancer, is often not possible with the small cellular samples obtained by EBUS-TBNA. A new transbronchial nodal aspiration needle (the Flex 19G EBUS-TBNA needle) has been developed with a larger needle diameter and more flexibility at the distal end, allowing better access to some lymph nodes stations. This needle can be passed down an EBUS scope and can hypothetically circumvent the deficiencies of EBUS-TBNA highlighted above by providing tissue adequate for histological assessment rather than cytological assessment alone.

This study aims to establish whether the use of the Flex 19G EBUS-TBNA needle can improve the diagnostic yield of EBUS sampling procedures compared to the use of the conventional TBNA needle, thereby allowing more accurate diagnoses and reducing the need repeat procedures or more invasive surgical biopsies, without causing an increase in complication rates. Patients with enlarged mediastinal and hilar lymph nodes referred for EBUS-TBNA will be randomised to have their nodes sampled by either the EBUS-TBNA needle (conventional procedure) or the novel Flex 19G EBUS-TBNA needle. The investigators hope to recruit 250 patients over a 24 month period.


Eligibility Criteria:
Inclusion Criteria:

* Scheduled for EBUS-TBNA as part of clinical care
* Lymph nodes larger than 10mm in diameter
* Age \> 18 years
* Written informed consent

Exclusion Criteria:

* Contraindication to needle biopsy (e.g. coagulopathy, anticoagulation, thrombocytopenia)
* Inability to obtain informed consent
IONTOPHORESIS Versus Ultrasound in Mechanical Neck Pain

to investigate the effects of Magnesium Sulphate Iontophoresis versus High Power Pain Threshold Ultrasound on pain, function and range of motion on active MTrPs found in the upper trapezius.

Myofascial pain syndrome (MPS) is a musculoskeletal chronic pain disorder that affects the majority of pain population and characterized by the presence of trigger points. MPS is usually associated with tenderness, spasm, movement limitation and referred pain .

Myofascial trigger points (MTrPs) are hyperirritable taut fibers of skeletal muscle. The taut fibers within the muscle create palpable nodules that may cause local pain, and refer pain elsewhere with soft tissue examination .

Eligibility Criteria:
Inclusion Criteria:

* Subjects, with age ranged from 19-23 years (Forman et al, 2014) from both genders. The subjects had active MTrPs in the upper fibers of trapezius muscle.

Exclusion Criteria:

* • History of whiplash injury.

  * History of cervical spine surgery.
  * Cervical radiculopathy or myelopathy.
  * Having undergone physical therapy within the past three months before the study.
  * Non- rheumatologic diseases as multiple sclerosis, thyroid dysfunction and chronic infection.
  * Rheumatologic condition as poly-articular osteoarthritis, rheumatoid arthritis and advanced cervical spine degenerative diseases.
Gait Analysis of Ankle Arthroplasty and Arthrodesis

Surgical options for managing hindfoot arthritis include: joint fusion, total ankle joint replacement or osteotomies (realignment) of bones. Fusion of arthritic hindfoot joints has been the accepted method of managing hindfoot arthritis for over a century. Recently, total ankle replacement has evolved as a treatment option for patients with end stage ankle arthritis. A comparison of gait for patients before and after hindfoot fusion or total ankle replacement will give further information about the outcome of this treatment. The principal aim of this project is to assess the effect of total ankle replacement or hindfoot fusion on gait. We are also interested in the outcome of the surgery and its effect on your symptoms (eg. pain and mobility). The results of this study will aid researchers in assessing this new treatment modality. Your involvement in this study is critical for the researchers to further analyze this new form of treatment and your time and involvement is appreciated.


Eligibility Criteria:
Inclusion Criteria:

1. Symptomatic Ankle Arthritis
2. Skeletal maturity
3. Able to give informed consent

Exclusion Criteria:

1. Avascular Necrosis of Talus
2. Obesity (BMI \>30)
3. Prior Ankle fusion or arthroplasty
4. Active or prior infection within 12 months
5. Medical condition precluding major surgery
6. Severe ipsilateral mid or hind foot deformity
7. Severe osteoporotic or osteopenic bone
8. Neuromuscular impairment
9. Age less than 40 years old
10. Cognitive or psychiatric impairment prohibiting accurate follow-up
11. Pregnancy
12. Workers compensation board patients