cyrilzakka/clinical-trials huggingface dataset:
Ecologically Valid Virtual Tasks vs Paper-pencil Methods in Cognitive Rehabilitation in Patients With Schizophrenia and Depression

Schizophrenia is heterogeneous and often disabling a disease that affects 1% of the population. Current psychopharmacological treatment significantly eliminates the presence of positive symptoms (especially delusions and hallucinations) and partly also negative symptoms (social withdrawal or abulia). In contrast, the cognitive deficits associated both with schizophrenia and depression are only limitedly influenced by pharmacological treatment.The cognitive impairment represents an important part of schizophrenia symptomatology and it has a severe negative impact on patients' quality of life. In depression is the impairment milder but still significantly contributes to patients' daily functioning. The profound deficit was repeatedly documented in the area of declarative and working memory. In this study, we study the effectiveness of virtual environment rehabilitation program focused on declarative memory, working memory and attention in comparison to standard paper-pencil rehabilitation led by an occupational therapist.

This study compares effectiveness of the virtual environment cognitive rehabilitation program with standard paper-pencil approach in within-subject design.

Participants with a diagnosis of schizophrenia, schizoaffective disorder or major depressive disorder will undergo a baseline assessment of cognition.

The participants will be at the baseline randomly assigned to each condition: virtual environment rehabilitation or paper-pencil rehabilitation. Then they will participate in 10-15 sessions (30-45 minutes) once or twice a week.

All participants will undergo retest assessment of cognition.

After completion of the first program the participants will be assigned to the different condition: to paper-pencil or virtual environment rehabilitation. After 10-15 sessions in the second condition the participants will once more undergo retest assessment of cognition.

Within-subject design is an effective tool in the development of scientifically proven treatment tools. This approach allows to obtain reliable information about the effectiveness of the method and to examine the influences of other variables (Steingrimsdottir and Arntzen 2015). This study will allow to get credible information on the importance of using the virtual environment in the context of cognitive rehabilitation in patients with schizophrenia and depression.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of schizophrenia and other primary psychotic disorders or diagnosis of major depressive disorder according to International Classification of Diseases-11

Exclusion Criteria:

* Severe visual impairment
* Age over 60 years
* Diagnosis of other psychiatric disorder than schizophrenia or major depressive disorder
* Physical handicap preventing the participant from participating in virtual environment training
* Refusal to sign an informed consent
Pilot Trial of Virtual and In-person STEP2

The goal of this clinical trial is to assess the feasibility of offering oncology patients a referral to the outpatient palliative care clinic based on virtual symptom screening before oncology clinic appointments, and to qualitatively explore factors patients consider when deciding to accept or defer a visit to this clinic.

Participants will be asked to complete questionnaires assessing quality of life, symptom burden, depression, anxiety, and satisfaction with care at baseline, 2, 4, and 6 months.

To improve equitable access to early palliative care based on symptom severity, the investigators developed Symptom screening with Targeted Early Palliative care (STEP) and demonstrated its feasibility in a previous trial. STEP was designed and tested before the COVID-19 pandemic and was based on symptom screening using tablets/computers in oncology clinics and in-person visits in the palliative care clinic. In response to changes in hospital care as a result of the COVID-19 pandemic, the investigators developed a novel, mixed in-person and virtually delivered intervention, STEP2.

The investigators propose to test STEP2 in a single-arm pilot trial, enrolling outpatients with advanced cancer and a prognosis of 6 months to 3 years. Participants will complete the Edmonton Symptom Assessment System-revised (ESAS-r+) tool electronically before oncology appointments (as is usual care in Ontario, Canada); in addition, if patients report moderate to high symptom scores, they will receive nurse-led triage and targeted referral to specialized palliative care. Quality of life, symptom burden, depression, anxiety and satisfaction with care will be assessed at baseline, 2, 4, and 6 months using questionnaires.

The objectives of this study are 1) to assess the feasibility of the STEP2 intervention, including completion of virtual symptom screening before oncology clinic appointments and completing triggered palliative care visits by video as well as in person; and 2) to explore factors patients consider when deciding to accept or defer a visit to the outpatient palliative care clinic.

Eligibility Criteria:
Inclusion Criteria:

* age 18+ years
* stage IV cancer (stage III or IV for lung or pancreas cancers; hormone-refractory for prostate and ER-positive breast cancers)
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* oncologist-estimated prognosis of 6-36 months
* willingness to complete routine online symptom screening at the Princess Margaret Cancer Centre

Exclusion Criteria:

* insufficient English literacy to complete study procedures
* oncologist-determined poor cognitive status
* already received or currently receiving specialized palliative care
Treating Hepatitis C in CRF Using Sofosbuvir and Daclatasvir

Sofosbuvir is the base of most treatment regimens for hepatitis C. In patients with renal failure the blood level of one of its metabolites (GS-331007) rises up to 20 folds. Although no particular adverse event has been linked to this metabolite sofosbuvir is not recommended for patients with renal failure mainly because of lack of data. Nevertheless there are anecdotal reports and small studies proving the safety of sofosbuvir in renal failure. This study addresses this lack of information by evaluating the safety and efficacy of sofosbuvir and daclatasvir in treating hepatitis C in 100 patients with renal failure.


Eligibility Criteria:
Inclusion Criteria:

* Positive qualitative hepatitis C virus RNA test on two occasions at least 6 months apart
* Renal failure (eGFR \< 30 cc/min) or under hemodialysis

Exclusion Criteria:

* Model for End-stage Liver Disease (MELD) score \> 20,
* Child's C (CTP score \> 12),
* Heart rate \< 50/min,
* Taking amiodarone
Low-vision Rehabilitation Program for Low-vision Patients and Care Givers

To evaluate health related quality of life (HRQoL) of low-vision patients and their care givers undergoing low-vision rehabilitation program (LVRP).

To conduct a pilot single-center, single blind longitudinal randomized controlled trial to evaluate health related quality of life (HRQoL) of low-vision patients and their care givers undergoing low-vision rehabilitation program (LVRP). LVRP includes functional vision assessments (low-vision refraction), prescription of a variety of visual aids including microscopes, magnifiers, telescopes, absorptive filters and electronic spectacle eyewear, large print books, and automatic self-transcending meditation plus essential skills for daily living and mobility training offered by Canadian National Institute for the Blind (CNIB) including demonstration of visual aids as well as training on proper use of visual aids.

Eligibility Criteria:
Inclusion Criteria:

* at least 50 years of age
* has low-vision,
* deemed competent such as no language issues or communication barriers, no self-reported or physician diagnosed mental health disorder besides having depressive and anxiety symptoms,
* have sufficient hearing to be able to follow verbal instructions and able to sit without physical discomfort for 30 minutes
* willing and able to attend 4 initial ASTM training sessions and at least 75% of weekly, bi-weekly and monthly follow up sessions,
* willing to dedicate 20 minutes twice per day to ASTM practice at their own home.

Exclusion Criteria:

* actively suicidal as per self-report (scoring 2 or more on item 9 of the Patient Health Questionnaire (PHQ-9) or on assessment by the physician,
* currently participating in other similar studies
* currently practicing any type of formal meditation regularly
Investigation of the Effects of Proprioceptive Neuromuscular Facilitation Techniques and Core Stabilization Exercises on Physical and Functional Parameters in Adolescents With Idiopathic Scoliosis

Adolescent Idiopathic Scoliosis (AIS) is a prevalent three-dimensional torsional disorder, primarily affecting adolescents during puberty. Characterized by a lateral deviation of the spine greater than 10°, AIS can lead to physical and psychological issues, including back pain, cosmetic deformity, and reduced quality of life. This study aims to compare the effects of Proprioceptive Neuromuscular Facilitation (PNF) techniques and Core Stabilization exercises on physical and functional parameters in adolescents with idiopathic scoliosis. This randomized controlled trial was conducted with 52 adolescents aged 10-18 years, diagnosed with AIS (Cobb angle of 10-30°). Participants were randomly assigned to either the PNF group or the Core Stabilization group. Both groups underwent a 10-week supervised exercise program, supplemented by a home exercise regimen. Primary outcomes included changes in the Cobb angle and Angle of Trunk Rotation (ATR). Secondary outcomes assessed quality of life (SRS-22), perceived trunk appearance (WRVAS), and physical function (6MWT and STS).

Adolescent Idiopathic Scoliosis (AIS) is a prevalent three-dimensional torsional disorder, primarily affecting adolescents during puberty. Characterized by a lateral deviation of the spine greater than 10°, AIS can lead to physical and psychological issues, including back pain, cosmetic deformity, and reduced quality of life. This study aims to compare the effects of Proprioceptive Neuromuscular Facilitation (PNF) techniques and Core Stabilization exercises on physical and functional parameters in adolescents with idiopathic scoliosis. This randomized controlled trial was conducted with 52 adolescents aged 10-18 years, diagnosed with AIS (Cobb angle of 10-30°). Participants were randomly assigned to either the PNF group or the Core Stabilization group. Both groups underwent a 10-week supervised exercise program, supplemented by a home exercise regimen. Primary outcomes included changes in the Cobb angle and Angle of Trunk Rotation (ATR). Secondary outcomes assessed quality of life (SRS-22), perceived trunk appearance (WRVAS), and physical function (6MWT and STS).

Eligibility Criteria:
Inclusion Criteria:

1. Aged between 10 and 18 years old,
2. First-time diagnosis of AIS,
3. Risser sign of 0-3 and a Cobb angle of 10-30°,
4. Sanders classification of 0-6,
5. Lenke curve Type 1 or Type 1A,
6. Volunteered to participate in the study.

Exclusion Criteria:

1. The presence of other types of scoliosis (e.g., congenital or neuromuscular scoliosis),
2. a history of spinal surgery,
3. use of a brace,
4. contraindications for exercise (e.g., cardiovascular or respiratory disorders),
5. previous AIS treatment,
6. rheumatological diseases, and/or other neuromuscular problems.
Phase II Clinical Study of Befotertinib in EGFR Non-classical Mutant NSCLC

This is a prospective, multi-cohort, single-arm Phase II clinical trial evaluating the efficacy and safety of befotertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), in patients with advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR non-classical mutations.

The study comprises two independent cohorts:

Cohort 1: Patients with EGFR uncommon mutations (G719X, L861Q, or S768I). Cohort 2: Patients with EGFR exon 20 insertion mutation

Primary endpoint: Objective response rate (ORR) assessed by RECIST 1.1. Secondary endpoints: Disease control rate (DCR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety profile (CTCAE v4.03).


Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years, ECOG performance status 0-2
* Histologically confirmed locally advanced/metastatic NSCLC
* Documented EGFR mutations: Cohort 1 (G719X/L861Q/S768I) or Cohort 2 (exon 20 insertion)
* No prior EGFR-TKI therapy
* Progression or intolerance to ≥1 line of platinum-based chemotherapy -≥1 measurable lesion per RECIST 1.1

Exclusion Criteria:

* Previous EGFR-TKI treatment
* Active CNS metastases (asymptomatic patients with stable lesions allowed)
* Severe cardiovascular disease (e.g., QTc ≥450 ms, myocardial infarction within 6 months)
* Active HBV/HCV/HIV infection
* Pregnancy or lactation
Timing and Resistance Exercise: Impact on Eating and Metabolism

Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.


Eligibility Criteria:
Inclusion Criteria:

* Age: 20-30
* weight stable for at least 6 months

Exclusion Criteria:

* Obesity (BMI \> 30 kg/m² or body fat percentage \> 25%)
* Hypertension (blood pressure over 140/90 mmHg)
* Heart disease
* Cancer
* Liver or kidney diseases
* Any other conditions that could potentially influence the study's outcomes
The Rotational Insertion Technique for ProSeal Laryngeal Mask Airway

The purpose of this study is to compare two insertion techniques of large size ProSeal laryngeal mask airway. We hypothesized that insertion of ProSeal laryngeal mask airway with 90-degree rotation would reduce the contact surface between the device and pharyngeal wall and make it easy to advance the device over the smooth angle against the posterior pharyngeal wall.We compared the success rate and incidence of complication of the standard technique with the rotational technique.

ProSeal laryngeal mask airway is not easy to be inserted due to its larger cuff especially in Asian population. First-time insertion success rate was lower and more time was required to achieve an effective airway even in well-trained physician. A number of techniques have been described to improve the insertion success rate. However, these techniques are only recommended to be used as backup when the digital or introducer tool techniques fail. We hypothesized that insertion of ProSeal laryngeal mask airway with 90-degree rotation would reduce the contact surface between the device and pharyngeal wall and make it easy to advance the device over the smooth angle against the posterior pharyngeal wall.We compared the success rate and incidence of complication of the standard technique with the rotational technique.

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists physical status I-II

Exclusion Criteria:

* Predicted difficult airway
* Mouth opening less than 2.5 cm
* Present sore throat
* High risk of aspiration
Message Framing on Recruiting Rh-D Negative Blood Donors

Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. On July 22, 2020 blood stockpile of O-negative and A-negative in Guangzhou Blood Center reached the warning line, and we took measures for emergency recruitment. O-negative and A-negative blood donors whose last donation dates were between January 1, 2018 and December 31, 2019 were identified and randomly assigned to four groups. Three different recruitment text messages were send three groups. We observed the re-donation rates among four groups within one week.


Eligibility Criteria:
Inclusion Criteria:

- O and A Rh- negative blood donors Last donations were between January 1, 2018 and December 31, 2019

Exclusion Criteria:

- With an obviously invalid phone number Serological results of the last donation were positive
Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age

The purpose of this study is to provide data on trends of morbidity due to Acute Otitis Media (AOM) (primary analysis) and morbidity and mortality due to pneumonia, and AOM related health care resources before and after the introduction of vaccination against pneumococcal disease within the Universal Mass Vaccination (UMV) in Colombia.


Eligibility Criteria:
Inclusion Criteria:

* Children aged less than five years with record of acute otitis media (with ICD-10 codes: H65 to H66) AND/OR.
* Children aged less than five years with record of pneumonia (with ICD-10 codes: J13 to J18) AND/OR.
* Children aged less than five years with any ICD-10 codes for respiratory diseases (J00-J99).

Exclusion Criteria:

• Not applicable
Urban Walking Circuits

The aim of this study was to assess the effectiveness of the implementation of walking urban circuits in increasing the level of physical activity and exercise capacity in severe chronic obstructive pulmonary disease (COPD) patients after being enrolled in a pulmonary rehabilitation program.


Eligibility Criteria:
Inclusion Criteria:

* severe COPD (post-bronchodilator Forced expiratory volume in one second (FEV1)/ Forced vital capacity (FVC) \<0.7 and FEV1 \<50%) and stable disease defined as no exacerbation, hospital admission or change in treatment in the previous three months.

Exclusion Criteria:

* The exclusion criteria were: other significant respiratory disease (bronchiectasis, lung fibrosis, asthma, etc.), active smoking, severe cardiovascular, neurological, musculoskeletal and/or metabolic pathology that could interfere with the results, alcoholism (\>80g/day) or severe malnutrition (BMI\<19kg/m2).
The Influence of Dietary Variety and Course Sequence on Fruit Intake in Preschool-Aged Children

The purpose of this study is to determine the extent to which manipulation of dietary variety and course sequence affects fruit intake and overall energy intake in preschool-aged children.

In the past two decades overweight and obesity rates in children (ages 2-19) have risen from 5% to 17%, with toddlers (ages 2-5) at 10%. Among children and adolescents the consumption of low-energy-dense foods, such as fruit and vegetables (F\&Vs), remain below current recommendations. Therefore, strategies to increase low-energy-dense F\&V intake and decrease high-energy-dense food intake aimed at young children are essential. Antecedents, or cues, can trigger eating. Therefore, manipulating food presentation can be utilized to produce certain behaviors. Dietary variety and course sequence are two examples of this relationship. It has been well established that high dietary variety leads to greater consumption patterns compared to low DV diets in adults. High DV has only been tested with problematic foods, and not with the goal of increasing F\&V intake. Additionally, serving a first course meal can act as a preload to decrease intake of the second course entrée. Dietary variety and course sequence manipulations have been experimentally tested with caloric intake goals but never with the goal of increasing F\&V intake. Therefore, the purpose of this study is to determine the extent to which manipulation of dietary variety and course sequence affects fruit intake and overall energy intake in preschool-aged children.

Eligibility Criteria:
Inclusion Criteria:

* All children that are ≥3 years of age enrolled in the ELC preschool with parental consent can participate.
* Eligible children must also like applesauce, peaches and cheese cubes, and be able to consume foods with a spoon.

Exclusion Criteria:

* Children allergic to applesauce, peaches, or chocolate pudding or who are lactose-intolerant will not be included in the study.
* Did not attend all feeding sessions.
* Did not consume more than 5 grams from any of the foods on an occasion.
Impact of Oncogeriatric Consultation on Quality of Life of Patients Aged 75 and More With Cancer

Among patients with cancer, 6 in 10 are over 65 years of age. In order to improve quality of life of aged cancer patients, the oncogeriatric consultation has been created. Oncogeriatric consultation aim to help oncologists determine the best solutions to combine therapy and quality of life. Factors influencing quality of life of cancer patients have been studied previously. However, these studies always focus on one specific cancer.

The aim of the study is to study factors associated with quality of life in patients aged 75 and more with cancer, notably the oncogeriatric consultation.

Eligibility Criteria:
Inclusion Criteria:

* male or female
* aged of 75 and more
* with cancer
* with indication of oncogeriatric consultation according G8
* agreeing to participate in the study

Exclusion Criteria:

-less than 75 years old