cyrilzakka/clinical-trials huggingface dataset:
Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Subjects will just have to agree to having a small amount of adipose tissue being removed during the bariatric surgery. The investigators will also collect a blood sample at that time. There will be no other visits for the subject.

Eligibility Criteria:
Inclusion Criteria:

* Women who are premenopausal or who are postmenopausal and have been for at least one year.

Males will be recruited to age match female subjects. All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

Exclusion Criteria:

* Women who are perimenopausal. Women who are on Hormone Replacement Therapy.
Seroprevalence of Chikungunya at the End of the First Chikungunya Outbreak in the French Antilles Within a Sample of Patients Treated for a HIV Infection

Late 2013, the first indigenous cases of chikungunya have been observed in the French Antilles. At the end of May 2014, almost all of the islands of the Caribbean were affected by the outbreak.

During the large epidemic which affected the Island of La Réunion in 2005/2006, the attack rate was 38%. The most active period was three months.

In this context, knowledge of the attack rate and the epidemic in the Caribbean is an important issue for outbreak management and modeling work.

As the chikungunya virus had never circulated in the Caribbean, determining the seroconversion rate can be achieved by realizing a seroprevalence survey among the general population at the end of the outbreak. Another simple method is to estimate the rate in a cohort of patients followed regularly and whose habitat is distributed throughout the territory studied.

The follow up of patients infected by the human immunodeficiency virus (HIV) in the French West Indies is almost exclusively performed in hospitals in department of Infectious and Tropical Diseases.The high prevalence of HIV and homogeneous distribution of infected patients on all of our territories, allow to hypothesize that the risk of transmission of arboviruses by exposure to mosquito bites is comparable to the general population. This patient cohort is well suited to study the emergence of Chikungunya in the French West Indie .

Primary objective :

To estimate the cumulative incidence at the end of the first Chikungunya outbreak in the French West Indies by estimating the prevalence of specific antibodies of chikungunya virus in a sample (randomly constituted) from patients infected by HIV and representative of the general population of Martinique and Guadeloupe

Secondary objective :

To estimate the frequency of asymptomatic infections by the chikungunya virus in the studied population To estimate the frequency of chronic forms of chikungunya in the studied population


Eligibility Criteria:
Inclusion Criteria:

* Adult (\> 18 years old)
* Followed for HIV infection at the 2 investigators centers (1 located at Martinique and 1 at Guadeloupe)
* resident in Martinique /Guadeloupe ( French West Indies)
* informed consent signed by the patient

Exclusion Criteria:

* patient who lived more than 6 month in an risk area for chikungunya virus infection
* patient with or documented chronic rheumatism
* patient who has received a blood transfusion during year 2013 or patient who is supposed to receive a blood transfusion during the study
* patient who has planned to live outside French West Indies during the follow up period
Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent viral skin infections. Recent studies have demonstrated that the skin of people with AD my have decreased antimicrobial peptide (AMP) expression. The purpose of this study is to compare smallpox virus replication and the number of AMPs and other antiviral molecules in people with AD, as compared to those seen in people with psoriasis or asthma, or healthy individuals.

AD is a chronic inflammatory skin disease characterized by frequent viral skin infections. Recent studies have found that components in the skin of people with AD may block AMP expression. AMPs are responsible for preventing infection from viruses. The purpose of this study is to examine smallpox virus replication and AMP expression in the skin of patients with AD as well as identify other antiviral molecules involved in immune response. These findings will be compared with those of people with psoriasis or asthma, or healthy individuals. This study will consist of one study visit at which skin and blood samples will be taken.

Eligibility Criteria:
Inclusion Criteria for Participants With AD:

* 2 years of age or older
* History of active or inactive AD OR eczema herpeticum, as defined by the ADVN standardized diagnostic criteria
* Parent or guardian willing to provide informed consent, if applicable
* Male or female of any race and ethnicity

Inclusion Criteria for Participants With Asthma or Psoriasis, and for non-atopic controls:

* 18 years or older
* History of psoriasis OR history of asthma not requiring systemic medications
* Parent or guardian willing to provide informed consent, if applicable
* Male or female of any race and ethnicity

Exclusion Criteria:

* Oral corticosteroids or any systemic immunosuppressive or immunomodulatory medication within 28 days prior to study entry
* Immunotherapy within 3 months prior to study entry
* History of bleeding disorder
* Aspirin, oral antihistamines, oral antibiotics, oral cyclosporine, or topical medications within 7 days of screening visit including, but not restricted to, Protopic, Elidel, topical corticosteroids, and topical antibiotics
* Anxiolytic agents and antidepressants within 2 days of screening visit
* Diabetic requiring medication
* Autoimmune or immunodeficiency
* Active fungal, bacterial, or viral infections within 7 days prior to study entry
* Active systemic cancer. Participants with uncomplicated nonmelanoma skin cancer are not excluded.
* Theophylline or leukotriene antagonists within 24 hours of screening visit
* Received any vaccination within 30 days prior to study entry
* Known lidocaine allergy
* Previously vaccinated for smallpox
* Pregnant or breastfeeding
Diagnostic Performance of Point of Care Ultrasound to Identify Intestinal Obstruction

As reported in previous studies, Point-of-Care Ultrasound (POCUS) has good performance for the diagnosis of bowel obstruction even when compared with CT. This inexpensive, radiation-free tool is available in a majority of ED. It is performed at the patient's bedside with immediate results. The learning curve allows Emergency Physicians (EP) to perform this exam after a relative brief training period.

The investigators aim to investigate the ability of POCUS performed before CT to exclude the diagnosis of bowel obstruction in patients admitted for abdominal pain.

Bowel obstruction (BO) is frequently suspected in the Emergency Department (ED). Computed Tomography (CT) is commonly used to diagnose this disease. However, CT is not always available in real-time, requires technician times, is associated with increased cost and exposes patients to radiations.

The researchers will investigate the diagnosis performances of POCUS for the diagnosis of BO with comparison with CT which will be considered as the gold standard. The wain objective will be the ability to exclude the diagnosis of BO, the main criteria being the negative predictive value. The secondary objectives will be the diagnosis performances (sensitivity, specificity, positive predictive value), duration and difficulty of POCUS

Eligibility Criteria:
Inclusion Criteria :

* Adult patients
* Abdominal pain
* Suspected bowel obstruction

Exclusion Criteria :

- Documented end-of-life precluding CT realization
An Innovative Mental Health Virtual Ward: Evaluation of Patient-Centered Outcomes

The goal of this study is to evaluate if admission to the Mental Health Virtual Ward (MH vWard) for mental health crisis stabilization is having a meaningful positive impact on patient reported outcomes and healthcare utilization. The objectives of this study are:

1. Prospectively measure demographic, recovery, service delivery, and systems use outcomes in a cohort of MH vWard admissions.
2. establish this cohort for use in future research.

As part of the intervention, participants will receive care in the MH vWard for an average of 5 days following a visit to an emergency department or crisis centre for a mental health crisis. While admitted to the MH vWard, participants will:

1. Engage in individual therapy and care planning with a clinician or psychiatry team.
2. Have engagement with formal (community providers) and informal supports (family, friends) for collateral and collaboration.
3. Receive medication reconciliation and management.
4. Participate in group programming.
5. Receive referrals for follow-up services.
6. Have access to after hours support.
7. Have access to the Telus Home Health Monitoring (HHM) App, which is custom designed to complement the services provided by the program.


Eligibility Criteria:
Inclusion Criteria:

* Individuals admitted to the Mental Health Virtual Ward.

Exclusion Criteria:

* None.
Effect of Laughter Yoga on Sleep Quality and Happiness

In this study, the effect of laughter yoga on sleep quality and happiness level in individuals with sleep problems will be investigated. Yoga exercises will be done for about 30 minutes with a laughter yoga instructor 3 days a week for a month.


Eligibility Criteria:
Inclusion Criteria:

individuals with sleep problems individuals without mental illness

Exclusion Criteria:

those who use sleeping pills those with mental disabilities
Study of the Safety, Tolerability and Pharmacokinetics of Testosterone Undecanoate in Hypogonadal Males.

Phase 1 Dose Escalating Study of the safety, tolerability and pharmacokinetics of testosterone in hypogonadal males.

M12-778 is a rising multiple dose, randomized, double blind, placebo controlled single center study. It will have 5 dose groups of 20 subjects in dose groups 1,2 and 3 and 24 subjects in dose groups 4 and 5; a total of 84 subjects . There will be a 7 day period between dose groups 1,2 and 3 to assess the safety of increasing to the next dose. Dose groups of 4 and 5 will be run in parallel. Subjects will be confined in center for 20 days for dose groups 1,2 and 3 and 33 days for dose groups 4 and 5.

Eligibility Criteria:
Inclusion Criteria

1. Serum total testosterone \< 300 ng/dL based on two blood samples obtained between 6 and 10 AM on two separate occasions at least 48 hours apart. Previously documented total testosterone results obtained within 6 weeks of Study Day -2 may be used during screening for subjects not currently on androgen replacement therapy, or following washout of androgen replacement therapy.
2. Subjects naïve to androgen replacement or washout of 12 weeks following intramuscular androgen injections; 4 weeks following topical or buccal androgens; and 3 weeks following oral androgens. Washout should be completed by Study Day -2.
3. Subject is judged to be in good general health as determined by the principal investigator based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12 lead electrocardiogram (ECG) performed at Screening.
4. Must voluntarily sign and date each informed consent, approved by an Institutional Review Board (IRB), prior to the initiation of any screening or study-specific procedures.

Exclusion Criteria

1. History of significant sensitivity or allergy to any drug, including androgens, castor oil or product excipients.
2. Previous history or current or suspected prostate or breast cancer, and/or previous history of cancer (except basal cell carcinoma of the skin).
3. Subjects not on a stable medication regimen for at least three months for the treatment of a chronic condition such as hypertension, hyperlipidemia or diabetes mellitus.
4. Use of known inhibitors (e.g., ketoconazole) or inducers (e.g., dexamethasone, phenytoin, rifampin, carbamazepine) of cytochrome P450 3A (CYP3A) within 30 days prior to study drug administration and through the end of the study.
5. Use of any drug within 5 half-lives of the last dose in the past 6 months prior to Study Day -2 without principal investigator and/or sponsor approval.
6. Receipt of any drug by injection within 30 days or 10 half-lives (which ever is longer) prior to study drug administration without principal investigator and/or sponsor approval.
Cost Comparison Between General Anesthesia and Regional Anesthesia in Shoulder Operations

Shoulder surgery can be done not only arthroscopy but also open technic. General or regional anaesthesia can be used at this surgery. Anaesthetic choice can be changed by comorbidity factors, patients or surgeons choice etc. At this study we aimed compare the general and regional anesthesia costs during operating room.

General anesthesia or ultrasound guided brachial plexus blocks (interscalene, superior trunk) can be used during shoulder surgery, as our routine. In this retrospective study, the data of patients who underwent shoulder surgery under regional or general anesthesia between 01 August 2021 and 31 March 2022 (8 months) in the operating room of the Samsun University Education and Research Hospital will be investigated. The characteristics of the patients such as age, presence of additional disease, operation indication, duration of stay in the operating room, and intraoperative medical agents will be recorded. Fees for materials used for general anesthesia and regional anesthesia will be determined. A fixed cost will be determined for the use of the operating room, including the salaries of healthcare workers. After calculating the group costs between both groups, statistical analyzes will be made.

Eligibility Criteria:
Inclusion Criteria:

* Open shoulder surgery, ASA I, II and III

Exclusion CriteriaS

* shoulder Arthroscopy , used regional anesthesia for only analgesia, American society of Anesthesiologists (ASA) score IV patients, emergency
A Study of Ritonavir/Indinavir Combination in HIV-Infected Patients

The purpose of this study is to determine how many HIV-infected patients continue taking ritonavir/indinavir combination after having taken indinavir three times a day as part of their anti-HIV drug therapy. This study also examines the safety and effectiveness of the ritonavir/indinavir combination.


Eligibility Criteria:
Inclusion Criteria

Patients must have:

* HIV infection.
* CD4 cell count greater than 100 cells/microliter.
* HIV RNA levels greater than 400 copies/microliter using the Roche Ultrasensitive assay.
* No acute illness.
* Consent of parent or guardian if less than legal age.
* No prior enrollment in this study.
* All entry criteria for this study met within 15 days prior to enrollment.

Exclusion Criteria

Co-existing Condition:

Patients with any of the following symptoms or conditions are excluded:

Any condition that in the opinion of the investigator may obscure proper observation of the safety or activity of the treatment regimens used in this study.

Concurrent Medication:

Excluded:

* Concurrent non-nucleoside reverse transcriptase inhibitors as part of the antiretroviral regimen.
* Any of the following medications with ritonavir:
* midazolam, clorazepate, diazepam, estazolam, flurazepam, triazolam, zolpidem, quinidine, amiodarone, encainide, flecainide, propafenone, bepridil, terfenadine, astemizole, cisapride, bupropion, clozapine, rifabutin, meperidine, propoxyphene, piroxicam, pimozide, dihydroergotamine, and ergotamine.
* Any of the following medications with indinavir:
* terfenadine, astemizole, cisapride, triazolam, midazolam. No requirement for rifampin or ketoconazole.
* Any concurrent treatment with other protease inhibitors.
* Other concurrent medication (including over-the-counter medicine or alcohol) without the knowledge and permission of the primary investigator.

Patients with the following prior conditions are excluded:

* History of significant drug hypersensitivity.
* Psychiatric illness that precludes compliance with the protocol.
* Receipt of investigational drug within 30 days prior to administration of study drug.
* History of acute or chronic pancreatitis.
* Anticipation of poor patient compliance with protocol.

Prior Medication:

Excluded:

Prior treatment with ritonavir.

Risk Behavior:

Excluded:

History of active substance abuse (i.e., recreational drugs or alcohol).

Included:

- Indinavir 800 mg three times a day plus unspecified nucleosides for at least 3 months.
Radial Visualization of the Foramen Arcuale Atlantis

Hemodynamics in the craniovertebral zone is often disturbed under the influence of a spondylogenic factor A complication of such changes can be from a slight decrease in cerebral circulation to ischemic changes in the vascular bed The patients underwent complex radiation diagnostics of the craniovertebral region of patients with verified Kimmerle's anomaly (N = 62) All examined patients underwent multispiral computed tomography (CT), ultrasound Doppler and transcranial Doppler (TCD) of the vertebral arteries (VA) Studies of the developmental variant of the first cervical vertebra with the presence of a bony bridge have shown that Kimmerle's anomaly can occur in all age groups

The vaulted hole was found in all age groups (more in young and middle age) The detection rate was within 16 3% of cases, that is, it occurs in every 5-6 people According to TCD data, Kimmerle's anomaly affects blood flow and was most often detected on both sides of the atlas In the unilateral variant, the anomaly was noted only on the left side It was found that the main structural change in the cerebral vascular bed, according to ultrasound diagnostics, is a change in the straightness of the vertebral arteries in the transverse processes of the cervical spine, including the atlas It should also be borne in mind that due to the complexity and mobility of the structure, patients with dysfunction of the craniovertebral zone receive therapy from doctors of various profiles, which requires a comprehensive diagnosis of this problem

Eligibility Criteria:
Inclusion Criteria:

* patients manifested themselves in the form of dizziness, various types of headache, mainly localized in the occipital region, nausea or flashing of flies before the eyes, in the rest - only cervicalgia

Exclusion Criteria:

* acute stroke, brain tumor
The Influence of Head and Neck Position on the Cuff Pressure Using Nasotracheal Tube

Nasotracheal tube is a commonly used for securing airways when performing general anesthesia in various oral and maxillofacial surgery such as tooth extraction, maxillary and mandibular fractures. After the nasotracheal tube is placed in the patient's trachea, the process of inflating the cuff at the end of the tube with air is required. If the cuff is inflated with excess air, the cuff may press the mucous membrane on the inner wall of the trachea, causing ischemia. Previous studies have shown that if the pressure in the cuff exceeds 30 cmH2O, it is highly likely to cause ischemia. In addition, it was found that the pressure in the excessively inflated cuff was associated with post-operative sore throat, vocal cord paralysis, and nerve damage. Moreover, the pressure in the cuff may vary according to the patient's head and neck posture. The pressure changes in the cuff may vary depending on the material and shape of the cuff. Therefore, we will investigate to evaluate the effect of head and neck posture on the pressure in the cuff of nasotracheal tube.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients over 20 years of age
* patients who require intubation of the nasotracheal tube to undergo oral and maxillofacial surgery under general anesthesia

Exclusion Criteria:

* Patients whose neck cannot be rotated due to cervical diseases, cervical fractures, and previous cervical surgery
* Patients undergoing emergency surgery
* Pregnant women
Effect of Continuous Glucose Monitoring System Alerts on Diabetes Management in the Hospital

Current continuous glucose monitoring (CGM) devices provide features that alert for current and impending adverse glycemic events.This trial aims to examine whether these glucose alerts provided added benefit on glycemic outcomes in patients with type 1 or 2 diabetes who required intensive insulin therapy during hospitalization.

Glycemic management for patients with diabetes during hospitalization is highly challenging, especially for those requiring intensive insulin therapy. For those patients, hypoglycemia is a common adverse event, which is associated with adverse clinical outcomes. Bedside capillary point-of-care (POC) glucose monitoring is the standard of care to assess glycemic control in the hospital. However, POC glucose testing only provides glucose measurements at specific time points, leading to missed information important for glycemic control. Continuous glucose monitoring (CGM) measures interstitial glucose every 5 min, thus providing a more complete glycemic profile during a 24 h period compared with standard POC glucose testing.

The cloud-based real-time continuous glucose monitoring (RT-CGM) and management system was previously observed to be safe and effective in guiding intensive insulin therapy. Therefore, this CGM intergraded system holds promise for improving glucose control in patients with diabetes during hospitalization. However, it is currently unclear if alerts are the main reason for the better outcome in the RT-CGM groups, or rather the fact that sensor values are available in real-time. Moreover, the current system provided the feature of predictive threshold alerts that could alert before the onset of clinical hypoglycemia or hyperglycemia. Thus, this trial aims to examine whether these glucose alerts provided added benefit on glycemic outcomes in patients with type 1 or 2 diabetes who required intensive insulin therapy during hospitalization.

Eligibility Criteria:
Inclusion Criteria:

1. Males and females ≥ 18 years.
2. Type 1 or type 2 diabetes with suboptimal glucose control requiring hospitalization, as determined by endocrinologists following clinical guidelines.
3. Willingness and ability to comply with the clinical investigation plan.

Exclusion Criteria:

1. significant hyperglycemia or diabetic ketoacidosis requiring continuous intravenous insulin infusion.
2. Female subjects who are pregnant or have a plan of pregnancy at time of enrollment into the study.
3. Current users of real-time glucose monitoring sensors or flash-glucose monitoring.
4. Participants were unable to tolerate tape adhesive around sensor placement area, or with medically documented allergy towards the adhesive (glue) of plasters, or with serious skin diseases (e.g. psoriasis vulgaris, bacterial skin diseases) around sensor placement area.
5. Patients expected to require operation, admission to the ICU and MRI procedures during hospitalization.
6. Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.