cyrilzakka/clinical-trials huggingface dataset:
Effect of Geometric Modifications of Implant Scan Bodies

The aim of this clinical study will be the effect of geometric modifications of implant scan bodies compared to conventional transfer techniques on passivity of all on four mandibular restorations

The aim of this study will be the effect of geometric modifications of implant scan bodies compared to conventional transfer techniques on passivity of all on four mandibular restorations.

Evaluation method:

The trueness of the final impression and the passivity of the final prosthesis will be evaluated by two methods:

Invitro evaluation For each patient in every group, the standard tessellation language (STL) files of scanned impressions will be superimposed on the reference file to determine the 3D surface, linear, and angular position analysis.

The STL files for both frameworks will be superimposed on the reference file to determine the passivity.

In vivo (Clinical) evaluation Radiographic evaluation using long cone parallel technique will be done for the framework after 6 month (T6) after one year (T12), and after 18 month (T18) from insertion.

Eligibility Criteria:
Inclusion Criteria:

* 1. All selected patients will have four implants placed in the mandibular interforaminal region according to all -on -four concept.

  2. All selected patients have a healthy mucosa and with no clinical complications.

  3. All patients are cooperative and approve the proposed treatment protocol.

Exclusion Criteria:

* 1. Patients who reject to participate in the study. 2. Patients who need implant placement as a result of previous implant failure.
Feasibility Pilot of Bright Light in the Intensive Care Unit

To evaluate the feasibility of providing daytime bright light in the ICU in a pilot randomized controlled trial.

To evaluate the feasibility of providing daytime bright light in the ICU in a pilot randomized controlled trial. Feasibility will be assessed via the following metrics: daytime bright light is acceptable and tolerable to patients and has high fidelity and sustainability as an intervention.

Eligibility Criteria:
Inclusion Criteria:

1. Hospital admission ≤30 hours at noon on enrollment day
2. Expected to say in the Medical Intensive Care Unit ≥24 hours after enrollment
3. Age ≥50 years
4. History of hypertension based on chart review and presence of 1 or more home blood pressure medications
5. Able to understand English

Exclusion Criteria:

1. At significant risk for pre-existing circadian abnormalities:

   * Severe chronic brain injury (Injury greater than 30 days ago resulting in the inability to live independently) OR Acute brain injury of any severity (Injury less than 30 days ago including acute intracranial bleed, traumatic brain injury, central nervous system infection, tumor)
   * Documented circadian disorder (\<1% population) or blind/disease of the optic nerve
   * Current history of substance abuse including alcohol (use in last 30 days)
   * Current or recent (last 1 year) shiftwork
2. Home medications include: melatonin, melatonin agonist
3. Transferred from an outside hospital, long-term care, rehabilitation, or acute care facility
4. History of bipolar disease (Bright light therapy possibly unsafe in this population).
5. Paralyzed (due to injury, disease or medications)
6. Diagnosed with hepatic encephalopathy in the setting of end-stage liver disease
7. Homeless
Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions

The purpose of this study is to evaluate the therapeutic benefit of Curodont Repair for the treatment of early buccal carious lesions compared to placebo.

All study participants must have two early class V carious lesions in need of a treatment but not of an invasive treatment (split-mouth design). One lesion will be treated with Curodont Repair and one with placebo as control (single application). 3 months later fluoride (Duraphat) will be applied on both lesions. Study duration is 9 months. For assessment visual and tactile evaluation, pictures, ECM, Diagnodent Pen, Canary System, VAS is used.

Eligibility Criteria:
Inclusion Criteria:

* Two class V carious lesions which do not require an invasive treatment
* Size and form of the lesions: the lesions must both be fully visible and assessable and accessible
* Patients must be able and willing to observe good oral hygiene throughout the study

  -≥ 20 teeth
* Permanent dentition and ≤ 65 years
* Willing and able to attend the on-study visits
* Willing and able to understand all study-related procedures
* Written informed consent before participation in the study
* Negative pregnancy test for women of childbearing potential

Exclusion Criteria:

* The two study lesions must not be on adjacent teeth
* No adjacent restoration on study tooth surface
* Fluoride varnish application \< 6 months prior to study treatment
* Patient suffers from diabetes
* Evidence of tooth erosion (due to excessive acidic drink consumption or reflux)
* History of head and neck illnesses (e.g. head/neck cancer)
* Any pathology or concomitant medication affecting salivary flow or dry mouth
* Any metabolic disorders affecting bone turnover
* Concurrent participation in another clinical trial with an investigational drug or device or participation in another clinical trial with an investigational drug or device within 30 days prior to study entry
* Pregnant and lactating woman
Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma

Program： Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma Aim：The early prediction of severe asthma, early intervention on the disease, reduce the family and the national finance.

design:This study is a single center randomized controlled trial designed by the Department of respiratory medicine, Xijing Hospital, as the main research unit.Compare the case group(severe asthma group and mild-and-moderate asthma group) and control group(healthy control group) by detecting the activity of MPO、NE、MMP-9 and ECP in the peripheral blood and the activity of HDAC2 in PBMCs of patients.

case:60

Case selection:

Inclusion criteria: age 18-75 years old; diagnosis of asthma was clear; informed consent was signed.

Exclusion criteria: poor compliance; cognitive ability is low; psychiatric disorders need to be combined with psychotropic medication.

Application of SPSS 19 statistical software. Measurement data were expressed as mean ± standard deviation.

First the data is normality tested and homogeneity of variance tested, according to the measurement data of normal distribution by SNK single factor analysis of variance; does not conform to the normal distribution of measurement data, using the Kruskal Wallis non parametric test. P \< 0.05 for the difference was statistically significant.

Eligibility Criteria:
inclusion criteria: healthy control group：

* Mainly from students,
* family members of patients without chronic lung disease,
* healthy population,
* age 18-75 years old, the gender is not limited. case group：
* The patient has been diagnosed with asthma in the outpatient clinic. The diagnostic criteria are in accordance with the Guidelines for Prevention and Treatment of Bronchial Asthma in the respiratory disease branch of the Chinese Medical Association.

In the past 1 year need guidelines of global asthma record instrument 4-5 drug treatment of asthma \[high dose inhaled corticosteroid with long-acting beta2 receptor agonist or leukotriene modifiers / theophylline or systemic hormone therapy is more than or equal to 50% of the time, in order to prevent into uncontrolled asthma, or even in the treatment is to control asthma patients for severe asthma.

exclusion criteria：

* Poor treatment compliance, or low cognitive ability to impact the self rating scale ;
* There are serious heart, liver, renal dysfunction, or other infectious diseases ;
* The individual who refuse to sign the informed consent.
Endobronchial Valves in Persistent Air Leak

Because an endobronchial valve is a one-way inspiratory airway blocker, it is hypothesized that it could be also used for controlling persistent air leaks while maintaining the drainage of secretions. The U.S. Food and Drug Administration approved in October 2008 the Spiration valve system designed to control air leaks in the lung that persist after lung surgery. This prospective observational study aims to evaluate the efficacy and safety of Spiration endobronchial valves in a prospective series of consecutive patients with a prolonged persistent air leak after anatomic surgical resection for cancer.

Persistent Air Leak (PAL) is independently associated with prolonged hospital length of stay, decreased patient satisfaction, increased morbidity or postoperative complications, and adds significantly to the cost. The management of air leaks is primarily preventive and therefore starts in the operating room with surgical techniques that can minimize the occurrence of post-operative air leaks, such as the creation of pleural tents or use of suture line glues or sealants. Notwithstanding some patients will after a lung resection have PAL. Any minimal invasive method that helps to increase our ability to treat (reduce and/or stop) the air leak in these latest cases carries an enormous clinical as well as cost-saving potential. Bronchoscopic occlusion of a segmental or subsegmental bronchus using endobronchial valves is such a less invasive method which has shown in case reports to interrupt an air leak.

Eligibility Criteria:
Inclusion Criteria:

* Prolonged (≥10 days postoperative) persistent air leak refractory to conventional treatments (such as prolonged drainage and/or chemical pleurodesis).
* Anatomical lung resection such as segmentectomy, (bi)lobectomy or sleeve lobectomy.
* Air leak after antero/posterolateral thoracotomy or video-assisted thoracoscopy (VATS).
* Type of air leak : expiratory.
* Size of air leak : any.

Exclusion Criteria:

* Prolonged air leak \<10 days postoperative.
* Pneumonectomy or none-anatomical lung resection.
* Lung resection for another indication than cancer.
* Previous reintervention or previous Heimlich valve for this air leak.
* Empyema
Long-term LASIK Follow up Study

Laser in situ keratomileusis (LASIK) is the most common corneal refractive surgery performed for correction of myopia. There are very few studies that have been performed to evaluate long-term outcomes after LASIK.

In this study, we will assess long-term outcomes 5 - 10 years after LASIK to assess stability of visual outcomes and long-term effect on corneal morphology with in vivo confocal microscopy. Clinical and corneal morphology outcomes will also be compared between patients who had flaps created with the microkeratome and femtosecond laser.

Volunteers will be eligible for enrollment into the study if have had LASIK surgery for correction of myopia or myopic astigmatism at the Kellogg Eye Center with either the microkeratome or femtosecond laser for LASIK flap creation between 5 and 10 years prior.

A complete ophthalmic examination and corneal confocal microscopy will be performed. The study visit will take approximately one hour.

Eligibility Criteria:
Inclusion Criteria:

* lasik surgery at the kellogg eye center between 2002 and 2005; at least 3 months of follow up after surgery

Exclusion Criteria:
A Brief Intervention for Cannabis Use

The purpose of this study is to compare two brief interventions targeting potentially problematic cannabis use in emerging adults (ages 18-25). Brief interventions are two 40-50 minute sessions separated by 1 week. Eligible emerging adults will complete a detailed cannabis assessment (biological and self-report), followed by one of the two brief interventions, and three follow-up assessments: one immediately after the second session and at 1- and 3-months post-intervention. Assignment to the brief intervention is random. Salivary samples will be collected at baseline, post-intervention, and both follow-ups, for a total of 4 samples, to be tested for tetrahydrocannabinol (THC) and cannabidiol (CBD).

Cannabis is the most widely used federally illicit substance among emerging adults (age 18-25) in the U.S., and frequent cannabis use is associated with myriad long-term health, social, and academic/occupational consequences. Despite this, rates of perceived risk of daily/regular cannabis use have steadily declined over the past two decades, and this is associated with increased frequency of use, a risk for for Cannabis Use Disorder (CUD). Brief interventions (BIs) are among the most frequently used approaches for addressing problematic or potentially problematic substance use in non-treatment-seeking adolescents and young adults. Although several cannabis brief interventions have been developed and tested to date, meta-analyses indicate that the efficacy of these interventions for emerging adults is mixed and the quality of studies is low, suggesting that novel approaches and rigorous methodology are necessary to improve efficacy. The current study will evaluate the feasibility, acceptability, and preliminary efficacy of a novel cannabis BI for emerging adults who frequently use cannabis.

Eligibility Criteria:
Inclusion Criteria:

* Ages 18-25
* Self-Report report cannabis use on at least 20 days of the past 30 days.
* Completion of an Intake Visit (PRO #94743)
* Submit a positive urine cannabinoid test during the Intake Visit

Exclusion Criteria:

* Currently engaged in substance use treatment for any type of substance use or currently treatment seeking
* History of substance use treatment for any type of substance
* Severe alcohol use disorder or presence of any substance use disorder (SUD) requiring a higher level of care
* Significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation
* Significant risk of suicide or homicide
Eccentric and Trunk Stability Exercise Program Effects in Young Soccer Players

The purpose of the present study is to investigate the effects of an in-season mixed training program on several physiological parameters of soccer players. Twenty-one U19 elite soccer players recruited and randomly assigned to either an 8-week specific training experimental group or a control group. The program will include an eccentric hamstring exercise, static balance exercises and core muscles strengthening exercises. Isokinetic hamstring and quadriceps strength, single leg static balance and lumbopelvic stability will be measured prior and after the intervention.

A total of 123 male Under-19 (U19) players from several soccer teams were initially invited for participation in the study after signing informed consent forms. following a second contact with the participants, questionnaire forms with inclusion and exclusion criteria were send for completion.

Based on their self-report and a clinical examination by a health professional, of the 103 players, 42 did not meet the inclusion criteria, while 12 players did not participate for personal reasons. Of the remaining 69 players, 48 players were excluded, including 3 players reporting an anterior cruciate ligament reconstruction, 14 because of lower extremity injury led to more than two weeks absence from training and 10 players because of secondary injuries or health problems that led to loss of training the past 3 months.

A neutral, blinded investigator with no further involvement in the study was responsible for randomized allocation of participants in two groups. All training sessions in the training group will be supervised by a fitness coach, who will ensure that the exercises are performed according to protocol.

Eligibility Criteria:
Inclusion Criteria:

* 16 to 19 years old soccer players
* Trained at least 3 times and played 1 match weekly, the past 4 years
* Healthy
* Free from muscle injuries in the 6 months prior to the study

Exclusion Criteria:

* History of anterior cruciate ligament rupture
* History of ankle, hip or knee injury with duration at least 1 week, in the 3 months prior to the study
* Muscle injury with duration at least 1 week, in the 3 months prior to the study
* Any reason resulting in 2 weeks loss of training the preceding 6 months
* Involvement in hamstring strengthening, core stability or balance training program in the 6 months prior to the study
Allergen Immunotherapy in Allergic Patients

Our aim was to evaluate the effectiveness of subcutaneous allergen immunotherapy with the symptom scores (RSS), visual analog scale (VAS) and medication scores (MS) and the impact on quality of life with rhinoconjunctivitis quality of life questionnaire (RQLQ) in allergic rhinitis patients sensitized to different allergens. Also the development of new sensitizations and asthma during the immunotherapy were determined.

Allergic rhinitis patients sensitized to at least one common aero-allergen who completed a three or five year period of allergen immunotherapy in our outpatient clinic between 2002-2013 were enrolled in the study and patients with allergic rhinitis who received only medical treatment were chosen as the control group. Patients were separated in two groups according to sensitization patterns including pollens or house dust mites. All patients were evaluated before immunotherapy, in the first and the fifth years of treatment and two years after the treatment.

Eligibility Criteria:
Inclusion Criteria:

* allergic rhinitis/asthma

Exclusion Criteria:

* pregnancy,
* malignity,
* autoimmunity
Use of Illustrated Material in Communication With the Patient in the Mechanical Ventilator

This study was carried out to determine the effect of the use of communication material on the anxiety and comfort of the patient in communication with patients receiving mechanical ventilators.As a result, the use of communication material reduces anxiety and increases patient satisfaction and comfort level. In communicating with intubated patients receiving mechanical ventilator therapy, the use of illustrated communication material is recommended.

The use ofcommunication material in communication with patients receiving mechanical ventilator support increases patient satisfaction and reduces communication difficulties. However, there was no randomized controlled clinical study showing the effect of the use of these materials on patient care outcomes such as anxiety and comfort level.Patients were randomly assigned to the control groups using illustrated communication material and intervention and routine communication methods. The research was carried out in three stages: preoperative, intensive care and one day after surgery. The primary outcomes of the study were pain, anxiety and comfort levels of the patients. Secondary outcomes were the patients' satisfaction with hemodynamic parameters and communication method.

Eligibility Criteria:
Inclusion Criteria:

1. Having undergone cardiac surgery
2. Being applied mechanical ventilator therapy
3. Being 18 or over
4. To have scored minimum 2 to maximum 2 from Richmond Agitation Sedation Scale (RASS)
5. Agree to participate in the research.

Exclusion Criteria:

1. not knowing Turkish
2. Having vision and hearing loss,
3. Having a cognitive or psychological problem that prevents them from communicating. 4. Having an intubation experience before

5. Bleeding, etc. in the early postoperative period. industrial development such as undergoing revision surgery or needing additional sedation,
Sitafloxacin and Ertapenem Treatment for Acute Pyelonephritis Caused by Escherichia Coli

The aim of the investigators' study was to evaluate oral and non carbapenem antimicrobial agents which can be used in outpatient for the treatment of non-bacteremic acute pyelonephritis caused by Extended Spectrum Beta Lactamase Escherichia coli. This study was conducted to compare the clinical and bacteriological outcomes of patients with non-bacteremic acute pyelonephritis caused by Extended Spectrum Beta Lactamase Escherichia coli who were treated with intravenous (IV) carbapenems followed by oral sitafloxacin or IV ertapenem.

A prospective randomized controlled trial of patients with a presumptive diagnosis of acute pyelonephritis caused by Extended Spectrum Beta Lactamase-producing pathogen was performed. Carbapenems was initially given to all patients. After day 3, patients were randomized to receive either oral sitafloxacin (100 mg twice daily) or intravenous ertapenem. The regular course of treatment was completed within 10 days.

Eligibility Criteria:
Inclusion Criteria:

* Age \>18 years
* Acute pyelonephritis by definition
* Positive urine culture for Extended Spectrum Beta Lactamase Escherichia coli ≥105 colony forming unit/mL
* Voluntarily consented to be enrolled in the study

Exclusion Criteria:

* Severe sepsis or septic shock
* Mixed organism of urine culture
* Positive blood culture
* Has other source of infection
* Has mechanical abnormality of urinary tract
* Immunocompromised conditions
* Retained Foley's catheter
* Pregnancy or lactation
* Previous urinary tract infections within 4 weeks
* Contraindicated for fluoroquinolones and carbapenems
Visual Perception in Preterm Infants

We aim to increase our knowledge of the impact of preterm birth on the maturation of the visual and auditory systems and on the development of multisensory perception

Specifically, we aim to evaluate the preterm infants' capabilities of detection and discrimination of different visual and auditory stimuli according to gestational age, post menstrual age and the duration of the postnatal life.

A secondary aim is to compare this competencies in preterm and full term control art term equivalent age.

The final aim is to optimize the hospital environment in order to make it correspond to the expectations and sensory abilities of very preterm infants.

Our hypothesis is that preterm birth exposes the infants to numerous atypical stimuli which could accelerate the processes of sensory maturation


Eligibility Criteria:
Inclusion Criteria:

* Newborn less than 32 weeks PMA hospitalized in the Hospital of Hautepierre, Strasbourg, France)
* Consent obtained from both parents
* Social insurance coverage

Exclusion Criteria:

* Any known malformation
* Brain lesions discovered on brain ultrasound (Intra-Ventricular hemorrhage grade III or IV periventricular Leukomalacia).
* Unstable clinical State
* Retinopathy Of Prematurity stage\> 2 or in zone 1
* Family history of abnormal color vision.
* Abnormalities in auditory testing
* Transfer to another hospital expected before 40 week PMA