cyrilzakka/clinical-trials huggingface dataset:
Hepatocellular Carcinoma and Rheumatoid Arthritis

Rheumatoid arthritis(RA) is a disorder with altered immunologic function and increased risk of developing malignancies, while studies examining the association between hepatocellular carcinoma (HCC) and RA remain lacking. The investigators aimed to investigate the risk of HCC between participants with and without RA.

The investigators did a retrospective, observational, nested case-control study in a cohort that was previously recruited from a population-based RA survey. All participants were enrolled prospectively in Taiwan's national health insurance between Jan 1, 1999, and June 30, 2009, and had follow-up data until Dec 31, 2009. RA was diagnosed based on the 1987 American College of Rheumatology diagnostic criteria. The investigators matched RA and non-RA subjects by propensity score in a 1:1 ratio. The primary outcome was the risk of developing HCC. Cox proportional hazards regression was applied to estimate the hazard ratio (HR) and 95% confidence interval (CI) of HCC for RA and non-RA cohort.

Eligibility Criteria:
Inclusion Criteria:

* subjects were required to have ≥2 RA diagnosis (International Classification of Diseases, Ninth Revision \[ICD-9-CM\]-codes 714.0x), and to be ≥18 years of age on the date of first diagnosis. And inclusion in the Registry for Catastrophic Illness Patient Database (RCIPD)

Exclusion Criteria:

* who were diagnosed with RA only once during the study interval, \<18 years of age when first diagnosed with RA, first diagnosed with RA after July 1, 2009, or not registered in the RCIPD were excluded
The Effect of Microfracture Procedure on Rotator Cuff Tendon Healing

Patients with complaints of shoulder pain or limitation of motion and had rotator cuff rupture diagnosed with magnetic resonance imaging will be analyzed and the patients with surgical indication will be included in a randomized fashion. One group of patient will undergo standard arthroscopic rotator cuff repair, while the other group will have microfracture procedure in addition to the standard arthroscopic repair. Before the operation, functional and clinical conditions will be recorded with Constant and American Shoulder and Elbow Surgeons Shoulder Score (ASES) universal shoulder scoring systems and Visual Analogue Scale(VAS) pain scale. The blood supply and healing of the tendon in the repair area will be compared by the doppler ultrasound (superb microvascular imaging) at the 2nd, 4th, 8th and 12th week after the operation. Post-operative clinical, functional status and pain levels will be evaluated with Constant, ASES and VAS pain scales at 24th week.


Eligibility Criteria:
Inclusion Criteria:

* degenerative rotator cuff tears

Exclusion Criteria:

* traumatic rotator cuff tears
* rheumatoid diseases
* previous surgery of rotator cuff tendon
* glenohumeral arthritis
* acromioclavicular arthritis
The Influence of Helping Relationships From Significant Others on Healthy Lifestyle and Quality of Life Among Patients With Chronic Kidney Disease: A Longitudinal Study

Helping relationships from significant others may assist patients with chronic kidney diseases to exercise health behaviors. Patients will adhere on the suggestions from medical staff and perform health lifestyle to maintain healthy behavior. The progress of the disease may be delayed.

The research is a 3-year study to explore the influence of helping relationships on healthy behaviors among patients with chronic kidney disease. Building on the findings from the past three years study and the literature on trans-theoretical Model, helping relationships will be articulated. A helping relation intervention will be applied to evaluate its effect on healthy lifestyle and quality of life.

The first year study will be a survey design. An instrument to measure the helping relationship will be established and tested. Total of 200 participants will be recruited to test the reliability and validity of the instrument. After evaluating the psychometric properties of the instrument, items may be revised according to the results. The second year of research will be a cross-section study. Of 250 subjects will be recruited to explore the correlations between helping relationships, healthy life styles, and quality of life. Data will be analyzed using hierarchical linear regression. In the third year, an experimental design will be applied to test the effect of a helping relationship intervention. One hundred and twenty subjects will be recruited and randomly assigned to the experimental and the control group for 60 subjects in each group. The helping relationships intervention program will be implemented on the experimental group. And the control group will be provided with routine nursing care. Data will be collected at baseline, the sixth and the ninth month of the third year of study. Data will be analyzed using generalized estimating equation measures to evaluate the effect of the intervention program.


Eligibility Criteria:
Inclusion Criteria:

* 20 years and older
* diagnosed with chronic kidney disease stage 1 to 4 or GFR≧30ml/min/1.73m2
* patients who has significant others
* patients who can speak Mandarin or Taiwanese

Exclusion criteria:

* Patient who limited to exercise
Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty

The goal of this research project is to evaluate injections of botulinum toxin A (Botox) as the treatment for knee flexion contracture after total knee arthroplasty (TKA). The current treatment for patients who do not achieve full extension of the knee (flexion contracture) after TKA consists of an aggressive physical therapy program, home stretching program, and the use of an extension orthosis (brace). Many patients do not tolerate wearing these braces. This initial project is designed to use injections of Botox as an adjunct to the standard current treatment and evaluate its efficacy. It is our hypothesis that a single injection into the hamstrings in addition to routine postoperative rehabilitation will result in improved knee extension and this improvement in function should endure without further treatment.


Eligibility Criteria:
Inclusion Criteria:

* Subject is at least 18 years of age
* Subject had a total knee replacement or total knee replacement revision surgery performed at Main Line hospitals such as Bryn Mawr Hospital, Lankenau Hospital, and Riddle Hospital
* Subject is measured to have at least 10 degree flexion contracture of the operative knee four to six weeks following surgery
* Subject has the willingness to complete scheduled follow up evaluations as described in the informed consent

Exclusion Criteria:

* Subject is currently involved in another study or has received investigational product or treatment within the last 30 days
* Subject is a prisoner
* Subject is anticipated to be non-compliant
* Subject is known to be pregnant
* Subject is mentally incompetent or unable to understand what participation in the study entails
* The subject has a known sensitivity or allergic reaction to Botulinum Toxin A and albumin
* The subject is unwilling or unable to give consent or to comply with the follow up program
Cirrhotic Patients With Septic Shock

Cirrhotic patients have a poor outcome in intensive care unit (ICU). Septic shock is a leading cause of ICU admission and death in this specific population. We performed a monocentric retrospective study; all cirrhotic patients admitted in the ICU with septic shock from 2002 to 2013 were included. The aim of the study was to identify prognostic factors for both short- and long-term mortality in these patients. Demographic, clinical and biological data, organ supports, and outcomes were collected. Univariate and multivariate analysis were carried out regarding both ICU and one-year mortality.


Eligibility Criteria:
Inclusion Criteria:

* age 18 or older
* diagnosis of cirrhosis
* diagnosis of septic shock at ICU admission

Exclusion Criteria:

* prior liver transplantation
The Incidence of Postoperative Pain After Using Different Types of Sealers

The aim of this randomized clinical trial is to evaluate and compare the incidence and intensity of post-operative pain after obturation using resin and silicon-based sealers.

The main objectives of root canal therapy are to achieve long-term comfort, function, and aesthetics for the patients and prevention of reinfection of tooth. These objectives are provided through complete cleaning, shaping, and obturation of canals of affected teeth .

Some patients may report moderate-to-severe pain and/or swelling following root canal treatment .

This is detrimental for both patient and dentist and may entail an unscheduled emergency visit by patients to relieve their symptoms.

Postoperative pain is considered a clinical outcome that exhibits the multifactorial nature of patients' responses to variables among treatment procedures such as maintaining the working length to the apical constriction, finishing the endodontic treatment in single visit or multiple visit, instrumentation technique and the type of endodontic sealer used for obturation .

Such pain occurrence is mainly due to mechanical, chemical or microbial injury to the periapical tissues .

Trauma of periapical tissue or bacterial extrusion and root canal sealer specifically, extrusion of root canal sealer can disrupt periodontal tissues and cause inflammatory reactions. The intensity of this reaction depends on the composition of the sealer .

Root canal sealers can play a crucial role in this regard by coming in contact with the periapical tissues through apical foramen and lateral canals causing a localized inflammation with a direct influence on the degree of inflammation based on the composition of the sealer in turn influencing postoperative pain levels .

Silicone is inert and biocompatible and has been widely used in medicine as an implant material Silicone-based root-canal sealers are also available. However, there are no data on the clinical performance of this type of material in endodontic treatment .

Eligibility Criteria:
Inclusion Criteria:

* • Patient's age ranges from 18-50 years old.

  * Patients with teeth diagnosed with symptomatic irreversible pulpitis.
  * Normal periapical condition confirmed by normal periapical radiograph
  * The teeth are restorable
  * Teeth are periodontally free, with no mobility and negative to percussion and palpation test.

Exclusion Criteria:

* • Teeth with immature roots

  * Non restorable teeth
  * Medically compromised patients with systemic complication that would alter the treatment.
  * Necrotic teeth
  * Teeth with apical periodontitis or periapical lesions
  * necrotic Teeth.
Intermittent Sedation Versus Daily Interruption of Sedation in Mechanically Ventilated Patients

Sedation is very important in critical care. Critically ill patients are submitted to many stressor factors that have potential to affect longterm outcomes. However, oversedation is associated with increased morbidity, including increased time of mechanical ventilation and ICU stay and longterm psychological complications. Daily interruption of sedation is associated with less time under mechanical ventilation and less posttraumatic stress disorder. Intermittent sedation, when compared with continuous sedation, is also associated with decreased time of mechanical ventilation. The aim of this study is to compare intermittent sedation with daily interruption. Our primary endpoint is free-days of mechanical ventilation in 28 days.

A comparison of intermittent sedation - keeping analgesia with fentanyl and midazolam or propofol as boluses if agitation (SAS 5 or more) after adequate analgesia - and daily interruption of sedation - analgesia with fentanyl and sedation wiht midazolam or propofol continuously with daily interruptions every morning until patients awake and can follow simple commands. Sedation is restarted in half previous dosage if agitation (SAS 5 or more) occur.

Eligibility Criteria:
Inclusion Criteria:

* Patients under mechanical ventilation with less of 24 hours and a expectative of stay intubated for more than 24 hours

Exclusion Criteria:

* Intubation secondary to a neurological cause
* Pregnant women
* Severe asthma or COPD decompensation
* Palliative care
Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy

Doctors use different treatments for people with Cerebral Palsy. Surgery is one option. Botulinum toxin injections are another option; these are given directly into spastic muscles to weaken them temporarily. Regular ongoing treatment (splinting, stretching and exercises) is another option. The investigators want to find out if surgery works better than Botulinum Toxin (Botox) injections or regular ongoing treatment (therapy), and if the effects of Botulinum Toxin injections last for longer than six months.

The specific aims of this study and the methodology for achieving them are:

1. To determine if tendon surgery for the forearm, wrist and thumb deformities of UECP is more effective than Botulinum toxin injections or regular ongoing treatment at improving function and quality of life for children with UECP. Children who are candidates for tendon surgery will be prospectively randomized to one of three treatment groups: standard tendon surgery, a series of three Botulinum toxin injections over a period of 12 months, and regular ongoing treatment. Validated tests of cognition, function and quality of life with tests of stereognosis and range of motion will be administered before, during and after treatment in order to compare outcomes of the three treatment groups.
2. To determine if serial Botulinum toxin injections have long-term beneficial effects on upper extremity function which outlast their paralytic effects.

Botulinum toxin has been shown to have beneficial effects on UE function while the muscles injected remain weakened by the toxin. Clinicians have theorized that improvements in UE function are maintained after the toxin wears off, but this has not been proven. Children randomized to the Botulinum toxin injection group will receive 3 injections. Their function will be tested before the first injection, while the paralytic results of the second injection are still in effect, and after the paralytic effects of the third injection have worn off, and the results compared in order to determine if functional improvements outlast the medicinal effects.

Eligibility Criteria:
Inclusion Criteria:

* diagnosis of UECP
* aged four to 17 years
* candidate for standard surgical management (tendon transfer)

Exclusion Criteria:

* subject could benefit from procedures in addition to standard surgical management and releases, and these procedures could be performed at the same anesthetic (for example, elbow flexor release)
* previous Botulinum toxin injection session in the affected UE in \< 1 year
* previous ipsilateral UE surgery
* primary language other than English or Spanish
* subject and/or parent unwilling to attend eight therapy sessions and perform home exercise protocol
Comparison of Effectiveness of Disinfectants

This is a comparative experimental study to compare the efficacy of chemical disinfection agents , sodium hypochlorite and chlorhexidine gluconate in decontaminating gutta percha cones

The study design is a comparative study which was done to compare the efficacy of chemical disinfection agents on decontaminating the gutta percha cones .

In this study, 124 standardized size-80 gutta-percha (GP) cones (Dentsply, Germany) were used to assess the efficacy of chemical disinfectants.

The cones were first sterilized using ethylene oxide to ensure baseline sterility. Following sterilization, 124 cones were allocated into two experimental groups (n = 62 each) for contamination.

group A . gp were immersed in 20ml of Enterococcus faecalis solution group B . gp were immersed in 20 ml of human saliva in patients undergoing root canal therapy

samples were incubated at 37°C for 72 hours to ensure uniform and thorough contamination

after incubation period cones were dried and divide into subgroups based on disinfectant agent applied .

The cones were immersed in disinfectant agent for 1 min and 10 min . Cones were dried again and immersed in brain heard infusion broth samples were again incubated at 37°C for 72 hours The presence of bacterial growth was determined by assessing turbidity in the broth, indicating viable microorganisms.

Eligibility Criteria:
Inclusion Criteria:

* healthy individual age between 20-40 patient needed root canal therapy

Exclusion Criteria:

* patient not willing to participate in study participants with systemic disease patients with neuromuscular disorder
Effectiveness of ECA Cream on Calcifying Shoulder Tendinitis

This pilot trail aims to assess the effectiveness of ECA cream in the treatment of calcifying shoulder tendinitis in terms of:

1. Reduction or removal of shoulder calcifications
2. Functional improvements
3. Pain improvements 10 subjects will be assessed prior and 1 and 2 months post intervention onset. The intervention will consist in the application of the ECA cream in the affected shoulder twice a day during 1 month.


Eligibility Criteria:
Inclusion Criteria:

* patients \>=18 years
* diagnosed of calcifying shoulder tendinitis diagnosed by a medical specialist (rehabilitation, orthopedic surgeon or rheumatologist) by x-ray
* with disease evolution of more than 3 months and less than 12 months
* that give their informed consent by writing

Exclusion Criteria:

* Previous shoulder surgery patients
* Patients with shoulder affections treated with shockwaves or corticosteroid injections.
Adipose-Derived Stromal Cells (ASC's) for Pressure Ulcers

This pilot study of 12 patients will test the safety and efficacy of applying autologous, adipose-derived stromal cells (ASCs), uncultured, on a Stage III or IV pressure ulcer or diabetic foot ulcers. Patients will undergo a minimal risk liposuction procedure to withdraw 50-100 cc of adipose tissue. The tissue would be processed to extract the stromal layer of cells that contain stem cells. The ASCs would be injected into a fibrin sealant to be applied to the wound. Patients would be followed for 6 weeks to assess wound healing and tolerance of the treatment.

Wound healing for Stage III and IV pressure ulcers or diabetic foot ulcers can take four to six weeks or longer and cost upwards of $40,000 to treat. Past studies have shown that adipose tissue contains progenitor cells or regenerative cells that can release multiple angiogenic growth factors and cytokines including vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF) and chemokine stromal cell-derived factor-1 (SDF-1). A current literature review revealed that there is research related to use of stem cells to enhance wound healing, in particular with ischemic or radiation-induced ulcers. However, there is limited research completed on use of stem cells or ASCs with pressure ulcers. The goal is to heal pressure ulcers faster and prevent further complications using the patient's own natural ASCs.

Eligibility Criteria:
Inclusion Criteria

* Males and females
* Stage III pressure ulcers measuring 5 cc - 36 cc in volume (as measured by filling the wound with Normal Saline).
* Inpatient or outpatient treatment of pressure ulcers
* Diabetic Foot Ulcer Stage 1 or 2 of any size
* Co-morbidities may include:

  * Peripheral Vascular Disease (PVD)
  * Coronary Artery Disease (CAD)
  * Chronic Renal Disease (CRD)
  * Chronic Liver Disease (CLD)
  * Hypertension (HTN)
  * Diabetes
* The ability of subjects to give appropriate consent or have an appropriate representative available to do so
* The ability of subjects to return for weekly wound assessments

Exclusion Criteria

* Patients with allergies to TISSEEL, Tegaderm, or silicon
* Diabetics with poor glucose metabolic control (HbA1c \> 9)
* Target wounds that are in close proximity to potential cancerous lesions
* Patients who require Negative Pressure Wound Therapy (NPWT), limb amputation, or surgical intervention at the target wound at the time of screening
* Wounds located on the face
* Patients with Stage 5 or 6 Peripheral Vascular disease (specifically, wounds that are caused by peripheral vascular disease such as leg ulcers)
* Wounds caused by diabetes mellitus (diabetic foot ulcers).
* BMI of \<16 Clinical signs of critical colonization or local infection
* Prolonged (\> 6 months) use of steroids
* Patients on active regimen of chemotherapy
* Patients receiving radiation in proximity of wound
* Decompensated chronic liver disease
Language Function in Patients With Brain Tumors

The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.


Eligibility Criteria:
Inclusion Criteria:

* Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.
* At least 18 years of age
* English as first language

Exclusion Criteria:

* Patients with high grade tumors
* History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia),
* History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease.
* History of significant claustrophobic reactions.
* Pregnancy
* Standard contraindications to MR examinations (e.g. implanted stimulator)
* Patients, who were treated prior to our first scan, will not be eligible to participate in this study
Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project)

The goal of this observational study is to learn about the personality attributes and values of people living with obesity that are part of the Latino community, and how these personality attributes and values can help to predict success during a weight loss program.

The main questions it aims to answer are:

* What are the personality attributes and values of people living with obesity that sign up to the LCSS-Latino Crossover Semaglutide Study trial?
* Can behavioral artificial intelligence (a computer formula) predict which patients will complete the LCSS-Latino Crossover Semaglutide Study trial?
* How do behavioral artificial Intelligence predictions (a computer formula) compare to clinician predictions of patient success?
* Can behavioral artificial intelligence (a computer formula) predict patient weight loss, calorie consumption and physical activity levels during the LCSS-Latino Crossover Semaglutide Study trial? Participants will be recorded in English and Spanish while responding to a question regarding participation in a weight loss study.


Eligibility Criteria:
Inclusion Criteria:

* Participation in the LCSS-Latino Crossover Semaglutide Study

Exclusion Criteria:

* Not a participant of the LCSS-Latino Crossover Semaglutide Study at the point of data collection