cyrilzakka/clinical-trials huggingface dataset:
Taping and Patellar Maltraction in PFPS Patients

Patellofemoral Pain Syndrome(PFPS) treatment is basically conservative, but there is no general consensus on the most appropriate therapeutic approach. The aim of this study was to examine the misalignment of the patellofemoral joint with MRI and compare the effectiveness of McConnell patellar taping and femoral lateral rotational taping techniques applied to exercise function on pain, patellar maltraction, functional status, balance and quality of life in patients with PFPS.

This is a single blinded randomized controlled trial, will be conducted at Ankara Yıldırım Beyazıt UniversityYenimahalle Education and Research Hospital. Evaluations regarding the parameters and inclusion criteria at the stage of diagnosis will be carried out by the Specialist Physician, exercise therapy and taping practices by the Specialist Physiotherapist, and the MRI measurements by the Specialist Radiologist. Fixed probability stratified randomization method will be preferred in order to ensure proportional gender distribution in the formation of groups and participants will be divided into 3 groups. An exercise program that includes stretching, strengthening and balance exercises accompanied by physiotherapist in the clinic will be applied to all individuals participating in the study for 2 times/week X 6 weeks (12 sessions). Only the exercise program will be applied to the first group. To the second group; McConnell patellar taping technique will be applied using rigid tape(Leukotape® P Rigid Strapping Tape, 38 mm X 10 m, USA) in addition to the exercise program in each session.To the third group; femoral lateral rotation taping technique will be applied using rigid tape in addition to the exercise program. Patients' patellar maltraction, pain function, balance, and quality of life will be assessed before and after treatment with MRI and clinical testing.

Eligibility Criteria:
Inclusion Criteria:

* Presence of anterior knee pain lasting more than 6 weeks
* Anterior or retropatellar knee pain is present in at least two activities (stair descending, stair climbing, squatting, running, jumping, sitting for a long time
* Presence of malalignment of patellofemoral joint in MRI examination \[Bisect offset index (BOİ) ≥57 and / or patellar tilt angle (PTA) ≥15\]

Exclusion Criteria:

* presence of knee trauma history and/or previous knee surgery
* presence limitation in knee joint range of motion
* presence of meniscopathy or lesion in knee ligaments
* presence of patellar subluxation or dislocation
* presence of a neuromuscular (upper or lower motor neuron lesions), cardiovascular or rheumatological disease
* pregnancy status
* presence of MRI contraindications
Routine Bile Collection for Microbiological Analysis During Cholangiography

Background: Antibiotic treatment of cholangitis often remains insufficient due to inappropriate antibiotic use or bacterial resistance.

Objective: To evaluate the role of routine bile collection during endoscopic retrograde cholangiography (ERC) or percutaneous transhepatic cholangiography (PTC) for microbiological analysis in the antibiotic management of cholangitis and to identify risk factors of microbial growth.

Design: Prospective, observational, diagnostic study.

Setting: Hannover Medical School, Hannover, Germany. Patients and Interventions: Consecutive patients undergoing ERC/PTC for biliary complications after orthotopic liver transplantation , malignancy, primary sclerosing cholangitis, benign strictures and choledocholithiasis.

Main outcome measurements: Microbiological examination of bile samples


Eligibility Criteria:
Inclusion Criteria:

* age above 18 years
* written informed consent

Exclusion Criteria:

* age under 18 years
* no written informed consent
DV2-HBV-27: Observational Pregnancy Registry

Purpose of the study is to evaluate pregnancy outcomes among women who received a dose of HEPLISAV-B within 28 days prior to conception or at any time during pregnancy


Eligibility Criteria:
Inclusion Criteria:

* 18 years and older
* HEPLISAV-B exposure within 28 days prior to conception or at any time during pregnancy

Exclusion Criteria:

* Less than 18 years of age
* HEPLISAV-B exposure greater than 28 days prior to conception
Compare the Effect on Cognitive Functioning of Two Formulations of Seroquel, Seroquel XR and IR in Patients With Stable Schizophrenia

This will be a phase IV 20 -32 day prospective, double blind, double-dummy, randomised crossover study that will evaluate the effect of quetiapine XR and quetiapine IR on cognitive performance in patients with schizophrenia stabilized on a single antipsychotic medication.


Eligibility Criteria:
Inclusion Criteria:

* Provision of written informed consent prior to any study specific procedures
* Documented clinical diagnosis of schizophrenia, paranoid type, for at least 2 years before randomisation meeting the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV, American Psychiatric Association 2000) criteria of schizophrenia (DSM-IV codes 295.3) confirmed by MINI version 5.0
* Outpatient status at enrolment
* Dose of quetiapine IR or quetiapine XR unchanged during the last 56 days before randomisation

Exclusion Criteria:

* Diagnosis of any DSM-IV Axis I disorder other than those included in inclusion criteria above within 6 months before randomisation (e.g., alcohol dependence or psychoactive substance dependence not in full remission, concurrent organic mental disorder, or mental retardation \[axis II diagnosis\]) of a degree that may interfere with the patient's ability to co-operate.
* Previous stable use of high dosage of benzodiazepines during one year or more
* Significant neurological medical history (complicated head trauma as judged by the investigator, epilepsy, meningo-encephalitis)
* Use of the following medication:
* other antipsychotic drug than quetiapine within 28 days prior to randomisation
* a depot antipsychotic injection within two dosing intervals (for the depot) before randomisation (Visit 2)
* other psychoactive drugs within 14 days prior to randomisation (hypnotic or anxiolytic drugs, other than those allowed)
* Use of concomitant therapy likely to affect cognition, Medication prohibited 28 days prior to randomisation: benzodiazepines, amphetamines, reboxitin, atomoxinetine, buspiron, donepezil, duloxetine, galantamine, ginko biloba, memantine, methylphenidate, modafinil, rivastigmine, tacrine, smoking cessation therapy varencicline and any dosage form of nicotine replacement therapy. Medication prohibited 14 days prior to randomisation: irreversible monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), biperiden, antoicholinergic agents (even if the indications are extra pyramidal symptoms or urinary symptoms)
Assessment of Enhanced Recovery After Surgery Implementation at Pediatric Surgery Practices in Mainland China

Enhanced recovery after surgery (ERAS) is a new mode to optimize perioperative management, the core of which is to reduce perioperative physiological and psychological trauma and stress damage, and accelerate postoperative rehabilitation. ERAS has been gradually introduced in pediatric surgery in recent years, however, there are limited reports on its overall implementation. We aimed to determine the popularity of ERAS among pediatric populations in mainland China.

The application of ERAS in children with congenital biliary dilatation (CBD) was investigated. A total of 31 province-level administrative regions in mainland China were involved and each of them had at least one participating center. A questionnaire was designed to assess the baseline adherence of 17 recovery elements and chief pediatric surgeons at each center were invited to complete.

Eligibility Criteria:
Inclusion Criteria:

* chief pediatric surgeons at each center

Exclusion Criteria:

* Incomplete questionnaire
Virtual Reality-Based and Face-to-Face Relaxation Programs in Pregnant Women with Preeclampsia

Preeclampsia, affecting 2-8% of pregnancies globally, is a leading hypertensive disorder in pregnancy. It is clinically characterized by elevated blood pressure (≥140/90 mmHg) after the 20th gestational week, often accompanied by proteinuria and systemic complications such as thrombocytopenia, liver dysfunction, and cerebral symptoms. This condition poses significant risks for both maternal and fetal health, increasing the likelihood of organ damage, preterm birth, and long-term cardiovascular and neurodevelopmental complications. Non-pharmacological interventions, including relaxation techniques, have been explored for symptom management. Progressive muscle relaxation (PMR) has shown efficacy in reducing stress, anxiety, and blood pressure. Recently, virtual reality (VR)-based relaxation techniques have gained attention for enhancing stress relief and improving health outcomes. This study aims to compare the effects of VR-based PMR with in-person PMR on maternal and fetal outcomes in preeclamptic pregnancies.


Eligibility Criteria:
Inclusion Criteria:

* Hospitalized with a diagnosis of preeclampsia.
* Gestational age ≥26 weeks.
* 18 years or older.
* Singleton and viable pregnancy.
* Willing to participate in the study voluntarily.

Exclusion Criteria:

* Multiple pregnancy.
* Pregnancy achieved through assisted reproductive technologies.
* Hearing or vision impairment in the pregnant individual.
* Fetal distress requiring emergency intervention.
* HELLP Syndrome or Eclampsia.
* History of vertigo.

Withdrawal Criteria:

* Cases where live birth does not occur.
* Participants who voluntarily withdraw from the study.
* Participants whose general health condition deteriorates during the intervention.
* Participants experiencing side effects from virtual reality headset use (e.g., dizziness, nausea, headache).
* Participants who do not practice progressive muscle relaxation at least once a week after the intervention.
Mitiglinide in Combination With Metformin vs. Metformin Alone in Patients With Type 2 Diabetes Mellitus

The primary objective of this study is to demonstrate whether mitiglinide administered in combination with metformin is more effective than metformin alone in patients with Type 2 diabetes mellitus (T2DM) whose blood sugar is not well controlled taking metformin alone. This is a 24 week study which measures improvement in blood sugar after of treatment.

This is a randomized, double-blind, placebo-controlled, parallel group study designed to evaluate the efficacy and safety of mitiglinide in combination with metformin in patients with T2DM who are less than adequately controlled on metformin alone. Patients who are receiving metformin alone for T2DM will be randomized equally into one of three treatment groups.

Eligibility Criteria:
Inclusion Criteria:

* type 2 diabetes diagnosed for at least 6 months
* stable metformin usage for at least 4 months
* HbA1c 7.5% - 10.5% inclusive
* no severe diabetic complications

Exclusion Criteria:

* chronic insulin use
* use of oral diabetic agent within 12 weeks
* acute or chronic conditions, excluding diabetes, that could compromise end point evaluation
A Study to Evaluate Routine Chest Tube Management After Minimally Invasive Lung Surgery

Chest tubes are routinely required after surgical procedures for lung cancer. This device is a flexible plastic tube that is inserted through the chest wall to remove air or fluid from around your lungs after surgery for lung cancer. There are two general strategies associated with the clinical management of chest tubes, active and passive suction. If suction is compared to driving a car, active suction is similar to pressing the gas pedal while passive suction is like letting your car move on its own. The suction approach taken by surgeons largely depends on how they were trained and some personal biases and beliefs. However there is no general consensus about which chest tube management strategy is best.

This research aims to compare two settings on a digital drainage system, a low suction (LS) mode - passive suction - and standard suction (ss) mode - active suction. From the data collected, the researchers will analyze whether LS or SS will lead to a better recovery after surgery.


Eligibility Criteria:
Inclusion Criteria:

1. Patients who are undergoing lobectomy or segmentectomy
2. Patients undergoing wedge resection to diagnose, or as definitive therapy for a lung nodule/cancer.
3. Able to understand and sign consent

Exclusion Criteria:

1. Patients undergoing pneumonectomy or bilobectomy
2. Patients undergoing resection for inflammatory conditions such as aspergillosis
3. Patients undergoing diagnostic wedge resection for interstitial lung disease
4. Patients undergoing redo-VATS or thoracotomy on the same side as current planned resection
5. Patients found to have a "frozen chest" at the time of surgery, requiring extensive adhesiolysis,
6. Patients who are discovered to have metastatic disease during the operation, so that resection is no longer indicated.
7. Patients where a clinical decision to place more than one chest-tube is made
Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries

The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.

The aim of the study is to investigate whether the expression and production of four adipokines \[adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)\] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.

Eligibility Criteria:
Inclusion Criteria:

1) Individuals undergoing cardiac surgery

Exclusion Criteria:

* Age \< 18 years
* HbA1c \> 7.0%
* Any change of antidiabetic medication the previous 3 months before the surgery
* GFR \< 60 mL/min/1.73 m2
* Liver disease
* Cancer
* Non-treated hyperthyroidism or hypothyroidism
* Autoimmune disease
* Infection
* Any change in body weight at least 5% the previous 3 months before surgery
* Significant dehydration.
* Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs
Assessing Knowledge, Beliefs and Attitudes Toward HPV Vaccination Among Parents in North West, Cameroon

The aim of this study is to assess knowledge, beliefs and attitudes of parents to young girls aged 9 to 14 years about HPV vaccines within some rural communities in the North West Region of Cameroon served by three hospitals in that area. To do this, we will conduct in-depth qualitative interviews with purposively sampled parents of girls aged 9 to 14 years, some of whom received HPV vaccine and some of whom did not. Interviews will continue until thematic saturation is reached (We anticipate a total 40 interviews). Data analysis will be done concurrently with interviews using thematic analysis.

The aim of this study is to assess knowledge, beliefs and attitudes of parents to young girls aged 9 to 14 years about HPV vaccines within some rural communities in the North West Region of Cameroon served by three hospitals in that area. Snowball sampling technique will be used. Parents of girls aged 9-14years will be included if the daughters have or have not received the HPV vaccine. Exclusion criteria include parents who are health care workers in any health institution, unwilling to provide consent, or inability to converse in English or pidgeon English. In-depth one-on-one interviews will take place using an interview guide. Interviews will be in English or pidgeon English. They will be taped and transcribed. Data will be entered into ATLAS Ti. Data analysis will be done concurrently with interviews using thematic analysis.Interviews will continue until theme saturation is reached (We anticipate a total 40 interviews).

Eligibility Criteria:
Inclusion Criteria:

* Parents of girls aged 9-14 years old living in Mbingo, Njinikom or Fundong health areas of northwestern Cameroon.

Exclusion Criteria:

* Parents who are health care workers or working in any health institution.
* Not willing to provide informed consent
* Not able to converse in English or pidgeon English
Quality Control of CE-Certified Phonak Hearing Aids - 2019_34

Phonak Hearing Devices pass through different development and study phases. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner. If the benefit is proven, their performance is then investigated regarding interdependency between all available algorithms, features and functions running in parallel in a hearing aid (pivotal/pre-validation studies) and, resulting from the pre-validation studies, they get optimized. Prior to product launch, the Phonak Hearing Systems get reviewed by a final quality control in terms of clinical trials. This is a validation study, investigating improved algorithms, features, functions and wearing comfort. This will be a clinical investigation which will be conducted mono centric at Sonova AG Headquarters based in Stäfa (Switzerland).

This study will compare two settings of an external microphone under real life conditions with experienced hearing aid users.

The external microphone streams the signal (e.g. speaker) directly into the hearing instrument (HI).

The subject should rate the devices in the lab and after a hometrial. The comfort, regarding to the loudness and the sound quality will be tested with the two settings at home and in the lab. Also the speech intelligibility will be tested in the lab.

This will be a clinical investigation which will be conducted mono centric at Sonova AG Headquarters based in Stäfa (Switzerland).

Eligibility Criteria:
Inclusion Criteria:

* experienced hearing aid user
* severe hearing loss
* willingness and interest in testing an external microphone healthy outer ear
* willingness to wear behind the ear hearing aids
* Informed Consent as documented by signature

Exclusion Criteria:

* the audiogram is not in the fitting range of the intended hearing aid
* limited mobility and not in the position to attend weekly appointments in Stäfa (Switzerland)
* participant is not able to describe experiences and hearing impressions
Comparative Evaluation of Ultrasound Guided Supraclavicular and Infraclavicular Subclavian Venous Catheterizations in Adult Patients Undergoing Major Surgeries

Comparison of two techniques of central venous cannulation of subclavian vein using ultrasound was performed. ultrasound guided central venous cannulation is the standard practice today but its use in subclavian vein is technically challenging and not much literature is available. In this study 96 Patients were randomized into one of the groups and compared for various outcomes. The primary outcome studied was the time taken for procedure. Secondary objectives included comparison of total access time using both the techniques,comparison of first attempt success rate, comparison of the quality of needle visualization and the comparison of immediate (mechanical) and delayed complication rates.


Eligibility Criteria:
Inclusion Criteria:

* Healthy adults requiring central venous cannulation.

Exclusion Criteria:

* History of prior catheterization.
* Limited sites for access attempts (other catheters, pacemaker, prior surgery).
* Previous difficulties during catheterization such as more than three punctures at one site, two sites attempted or failure to gain access.
* Previous mechanical complications during catheterization.
* Patients with infection at puncture site and contralateral pneumothorax.
* Patients with trauma to clavicle and upper ribs, distorted anatomy of neck or clavicles.
* Cervical spine injury.
* Known vascular abnormality.
* Untreated coagulopathy such as International Normalization Ratio(INR) ≥ 2, activated partial thromboplastin time \>1.5 of normal or platelets \<50,000/mm3
* After 3 attempts at needle puncture.
Effect of Thoracic Manipulation on Latent Trigger Point

The aim of this study is to investigate the effect of one session thoracic manipulation on pressure pain threshold and rhomboid muscle strength in healthy individuals with latent trigger point.

Within the scope of the study, all individuals studying at Sarayköy Vocational School and volunteering to participate in the study will be screened.Immediately after determining the latent trigger points in the rhomboid muscles, the participants will be randomized by computer method and divided into 2 groups. Participants who underwent thrust thoracic manipulation will form the study group, and participants who received sham thrust thoracic manipulation will form the control group.Pressure pain threshold will be evaluated with an algometer and rhomboid muscle strength will be evaluated with a hand dynamometer.

Eligibility Criteria:
Inclusion Criteria:

* not having any systemic disease
* not having any neuromuscular deficit
* To be defined as inactive (less than 30 minutes of moderate physical activity five times a week) according to the minimum activity guidelines published by the American College of Sports Medicine

Exclusion Criteria:

* Being actively involved in any sport
* Participating in a regular exercise program
Early Small Bowel Obstruction Following Laparotomy For Trauma

The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal adesions. The incidence however, of small bowel obstruction (SBO) resulting form these adhesions is far lower. To date, it is unknown which risk factors predispose these patients to develop SBO. Several have been proposed, such as age, peritonitis, or surgery for small bowel injury resulting from gunshots. None of them however, has been widely accepted.

During the last 20 years the significant lifetime risks associated with this phenomenon and its impact on the quality of life of patients has been well recognized. In addition, the burden on healthcare resources due to complications caused by adhesions is increasing and medicolegal consequences are rapidly evolving.

Early SBO following laparotomy for trauma is a poorly described entity. A few retrospective, single institution studies with a low number of patients have tried to address this issue. However, these studies either included a subset of trauma patients, i.e. patients sustaining penetrating trauma,\[4\] or patients undergoing a negative or non-therapeutic laparotomy, or examined only the incidence of SBO requiring surgical intervention. In addition, recent data regarding this issue is lacking, especially after the implementation of the damage control concept and the other advances in trauma surgery.

The aim of this study is to define the incidence of early SBO following laparotomy for trauma and to examine possible risk factors associated with its development.

This is a retrospective review of all trauma patients admitted to the Los Angeles County - University of Southern California (LAC+USC) Medical Center from January 2006 to June 2009 (3.5 years). The trauma registry will be utilized to identify patients \>= 15 years old who underwent a laparotomy during the study period and survived \> 72 hours. For patients meeting inclusion criteria, all imaging studies obtained within the hospital course will be reviewed to identify patients who developed early SBO. The rationale for utilizing imaging studies is that obtaining these studies for patients with high suspicion of SBO is standard practice to establish the diagnosis. The charts of these patients will subsequently be reviewed and data will be collected using a predefined data collecting form.

Eligibility Criteria:
Inclusion Criteria:

* Exploratory laparotomy
* Survival \> 72 hours

Exclusion Criteria:

* No exploratory laparotomy
* Survival \<= 72 hours