cyrilzakka/clinical-trials huggingface dataset:
Feasibility of a Modified Positive Airway Pressure Device to Treat Sleep Disordered Breathing

This study will use a modified version of a positive airway pressure device to supply air to the participant, while undergoing supervised polysomnography. Positive airway pressures are typically applied to many patients with hypoventilation, in this study these pressures will be titrated by a qualified sleep technician. During the night these pressures will be altered to optimise comfort.


Eligibility Criteria:
Inclusion Criteria:

* Aged 18+
* Patients diagnosed with obesity hypoventilation syndrome (OHS) and/or obstructive sleep apnea (OSA) by a practicing sleep or respiratory physician, requiring positive airway pressure (PAP) therapy

Exclusion Criteria:

* Recent cardiac or respiratory arrest
* Gastro intestinal bleeding, ileus or recent gastrointestinal surgery
* Coma, decreased level of consciousness or agitation
* Anatomical or subjective difficulty with airway access e.g. facial surgery, trauma, vomiting upper airway obstruction
* Cerebrospinal fluid leak, abnormalities of the cribiform plate or prior history of head trauma.
Clincal Study of Reduced Target Radiotherapy in Nasopharyngeal Carcinoma

To determine whether subtractive radiotherapy can significantly reduce the acute side effects of radiotherapy and improve the quality of life of patients on the basis of ensuring the existing curative effect.


Eligibility Criteria:
Inclusion Criteria:

1. Histopathologically confirmed nasopharyngeal nonkeratologic carcinoma (differentiated or undifferentiated, i.e., WHO type II or Type III).
2. The clinical stage is TanyN2-3M0, III-IVa (AJCC 8th edition stage).
3. Patients who have not received radiation therapy before.
4. After induction chemotherapy, CR or PR were evaluated by radiography.
5. Age 18-65 years old.
6. ECOG score of 0-1.
7. Good organ function
8. The patient has signed an informed letter and is willing and able to comply with the planned visits, treatment plans, laboratory tests and other research programs.

Exclusion Criteria:

1. Patients with keratinizing squamous cell carcinoma account for only about 5% of the total pathological types, and the sensitivity of radiotherapy is poor compared with the other two types heterogeneous, so nasopharyngeal carcinoma with pathology of keratinizing squamous cells (WHO type I) is excluded.
2. Patients with relapsed and distant metastases.
3. The metastatic lymph nodes are located in the target area (Ib zone, the lateral group of the retropharyngeal lymphatic drainage area (VII), and the cervical lymphatic rainage area The medial border moves from top to bottom from the medial border of the common carotid artery to the lateral border, from the annular cartilage to the superior sternal border, sternoclavicular.The triangular area between the anterior and posterior edges of the medial mastoid muscle and the anterior and lateral border of the jugular arteriovenous sheath and lateral border of the thyroid glanddomain).
4. Nasopharyngeal primary tumor or retropharyngeal metastatic lymph node invasion of oropharynx.
5. Severe heart disease, lung dysfunction, heart function, lung function lower than grade 3 (including grade 3).
6. Those whose laboratory test values do not meet the relevant criteria within 7 days before enrollment.
7. Those who have participated in clinical trials of other drugs within 3 months before treatment.
8. Pregnant or lactating women.
9. Patients assessed by investigators to be unable to cooperate with regular follow-up due to psychological, social, family and geographical reasons.
A Reverification of the Berlin Definition Plateau Criteria in Golmud

This study is a single-center retrospective study. According to the Berlin diagnostic standard, ARDS patients admitted to the Department of severe Medicine, Golmud People's Hospital from January 2015 to june 2022 were divided into three groups: mild (142mmHg \< PaO2/ FiO2 ≤ 213 mmHg), moderate (71mmHg \< PaO2/ FiO2 ≤ 142mmHg) and severe (PaO2/ FiO2 ≤ 71 mmHg). The ICU mortality, 28-day mortality, non-ventilator time in ICU, ICU hospitalization time observed respectively.


Eligibility Criteria:
Inclusion Criteria:

* Meet the diagnostic criteria of ARDS

Exclusion Criteria:

* length of stay in hospital less than 48h Data missing younger than 18 years or older than 80 years
Product Testing of the FaceView Mask™: Usability Survey

The study aims to gather participants' perceptions of the novel transparent surgical N95 respirator vs. a conventional surgical N95 respirator. Following fitting of the masks, participants will complete a questionnaire to provide their perceptions of fit, comfort, ease of use, and benefit to communication.

The investigators will recruit adult participants to complete a usability survey on a transparent surgical N95 respirator (i.e., FaceView mask) designed to improve communication. The study aims to gather participants' perceptions of the novel transparent surgical N95 respirator vs. a conventional surgical N95 respirator. Following fitting of the masks (5 minutes wear time each), the participants will complete a questionnaire to provide their perceptions of fit, comfort, ease of use, and benefit to communication.

Eligibility Criteria:
Inclusion Criteria:

* at least 18 years old
* have no health conditions that would prevent them from safely wearing an N95 respirator (e.g., severe asthma, chronic obstructive pulmonary disease)
* read in English and communicate in English or American Sign Language
* be able to provide or arrange their own transportation to the study location

Exclusion Criteria:

* Children are to be excluded from the proposed research project because the current FaceView Mask™ is designed for adults
* Adults who are non-English communicators
* Any adult with health conditions that would prevent them from safely wearing an N95 respirator (e.g., severe asthma, chronic obstructive pulmonary disease)
Effectiveness of Dual Task Training in Total Hip Arthroplasty

This study was planned to investigate the effectiveness of usual care and dual task program in patients who underwent total hip arthroplasty surgery. It is aimed to evaluate pain intensity, disability level, mini mental status, coordination, balance and functional status of the patients. The study will be conducted with volunteer patients who are followed up by the Orthopedics and Traumatology outpatient clinic of Muğla Training and Research Hospital and who have undergone total hip arthroplasty surgery. The evaluations will be performed in the Orthopedics and Traumatology outpatient clinic of Muğla Training and Research Hospital. It is aimed to evaluate at least 24 patients for the study.


Eligibility Criteria:
Inclusion Criteria:

* Having undergone unilateral total hip arthroplasty surgery and being 6 weeks postoperative
* Participate in all necessary follow-up assessments
* 60 years of age or older
* Understand simple commands
* Signing the consent form

Exclusion Criteria:

* A previous history of total hip arthroplasty
* Presence of revision surgery
* Presence of severe osteoarthritis in the contralateral hip
* Severe acute metabolic neuromuscular and cardiovascular diseases
* Severe obesity (bki\>35)
* Presence of malignancy
* Have any other orthopedic or neurological problem that may affect treatment and assessments
* Situations that prevent communication
* Lack of cooperation during the study
Effect of Dexmedetomidine on the Characteristics of High Volume/Low Concentration Ropivacaine in a Caudal Block in Pediatrics

The investigators perform this study to evaluate the effects of caudal Dexmedetomidine (DEX) added to high volume/low-concentration of ropivacaine in children undergoing orchiopexy.


Eligibility Criteria:
Inclusion Criteria:

* children undergoing ambulatory orchiopexy,
* ASA status I

Exclusion Criteria:

* mental retardation,
* developmental delay,
* neurological or psychiatric illness,
* coagulation disorder,
* spinal anomalies
Impact of Defecation Posture on Ease of Bowel Movements in Patients With a Rectocele

The study aims to determine if defecation posture, when using a defecation posture modification device (DPMD), will improve ease of bowel movements in patients with pelvic organ prolapse, specifically rectoceles.


Eligibility Criteria:
Inclusion Criteria:

* Patients with pelvic organ prolapse, including a rectocele (posterior compartment measurements to Stage 2 or greater) that endorse bowel dysfunction, based on our office standard screening questionnaires

Exclusion Criteria:

* Anyone currently using a defecation posture modification device Unwillingness or unable to participate in the study Planned travel, inability to use device during the study period Patient preparing to undergo pelvic reconstructive surgery prior to the end of the study period Presence of ileostomy/colostomy Bowel disease such as Crohn's disease or Ulcerative Colitis Daily opiate use Wheelchair bound If device may pose fall or safety hazard risk to patient, such as need for walker or cane for ambulation.

Patients weighing over 250 lbs, per manufacturer guidelines for the device Inability to understand English Pregnant women
Global Behavior and Periodontal Disease in Down's Syndrome Patients

This study aimed at correlating global behavior of Down's Syndrome patients to periodontal disease status.

There is a higher prevalence and severity of periodontal disease in Down's Syndrome patients. Plaque levels in these patients are high due to poor hygiene habits. Behavior also may contribute to the overall periodontal condition.

Eligibility Criteria:
Inclusion Criteria:

* Down's Syndrome Diagnose characterized by the whole chromosomal aneuploidy 15 to 52 years
* Absence of severe hearing loss could impair the comprehension about the dental treatment
* Absence of severe visual loss that could impair the comprehension about the dental treatment
* Presence of at least four teeth being one for hemiarch.
* Diagnose of gingivitis and periodontitis
* Absence of acute periodontal disease and necrotizing periodontal disease.

Exclusion Criteria:

* Smokers
* Use of alcohol
* Menopause
* Pregnancy
* Absence of all teeth
* Uncontrolled diabetes mellitus
* Uncontrolled hyperthyroidism
* Angina
* Uncontrolled hypertension
* Coagulopathy
* Use of illicit drugs
* Head and neck radiotherapy
* Chemotherapy
* Non-cooperative patients or patients with other diseases as autism.
A Study in Adults With Type 1 Diabetes

The purpose of this study is to compare the effectiveness and safety of LY2963016 versus Lantus when taken once daily in combination with insulin lispro before meals three times a day.


Eligibility Criteria:
Inclusion Criteria:

* Have type 1 diabetes mellitus based on the disease diagnostic criteria \[World Health Organization (WHO) Classification\]
* Have duration of diabetes greater than or equal to one year
* Have Hemoglobin A1c (HbA1c) less than or equal to 11.0%
* On basal-bolus insulin therapy for at least 1 year \[basal insulin must be once daily (QD) injection of human insulin isophane suspension (NPH), Lantus, or detemir and combined with mealtime injections of human regular insulin, or insulin analog lispro, aspart or glulisine\]
* Have a body mass index (BMI) of less than or equal to 35 kilograms/square meter (kg/m²)

Exclusion Criteria:

* Have had more than one episode of severe low blood sugar (defined as needing someone else to help because you had very low blood sugar) within the 6 months before entering the study
* Have had more than one episode of diabetic ketoacidosis or emergency room visits for uncontrolled diabetes leading to hospitalization within the 6 months before entering the study
* Have known hypersensitivity or allergy to any of the study insulins (insulin glargine or insulin lispro) or to excipients of the study insulins
* Have significant renal, cardiac, gastrointestinal or liver disease
* Have active cancer or cancer within the past 5 years
Insole on Morton's Neuroma

Objective: The aim of the present study was to assess the effectiveness of insole with metatarsal support on pain in patients with Morton's neuroma and the impact of this insole on function, load distribution in the plantar region, gait variables, quality of life and satisfaction with insole use.

Methods: A randomized, controlled, double-blind, clinical trial with intent-to-treat analysis. Seventy-two patients with Morton's neuroma were randomly allocated into a study group and control group. One week following the baseline evaluation, the study group received insole with metatarsal support made of ethyl vinyl acetate and the control group received a flat insole of the same material, color and density. The groups were evaluated after 6, 12 and 24 weeks of insole use. The following assessment parameters employed: pain when walking and at rest (END); quality of life (SF-36); foot function (FFI and FHSQ); six-minute walk test (6MWT) and foot pressure analysis using the AM Cube FootWalk Pro program.


Eligibility Criteria:
Inclusion Criteria:

* Patient with clinical and radiological diagnosis (magnetic resonance or ultrasound) of Morton's neuroma.
* Pain in the foot with VAS between 3-8 cm to walk.
* Over 18 years.
* No distinction of sex
* Agree to participate of the study and sign the informed consent form.

Exclusion Criteria:

* Other symptomatic musculoskeletal diseases in MMII.
* Symptomatic diseases of the central and peripheral nervous system.
* Diabetes Mellitus.
* Rigid deformities on foot.
* Use of insoles in the last three months.
* Physiotherapy in the last three months.
* Infiltrations on foot and ankles in the last three months.
* Previous or expected surgery in the next twelve months.
* Allergy to the material of the insole.
* Mental deficiency.
* Geographic inaccessibility .- Use of corticosteroids or NSAIDs in the last month
The EFFECT of CHIROPRACTIC THORACIC MANIPULATION on PAIN, DEPRESSION, SLEEP and QUALITY of LIFE in PATIENTS with FIBROMYALGIA

This study aimed to investigate the effects of thoracic chiropractic manipulations on pain intensity, depression levels, sleep, and quality of life in women diagnosed with fibromyalgia. The research included 50 female participants aged 25-45 who had been diagnosed with fibromyalgia between 2022 and 2023 at Şişli Hamidiye Etfal Education and Research Hospital. The participants were randomly divided into two groups: a chiropractic treatment group and a control group. Both groups completed pre-treatment assessments using the Visual Analog Scale (VAS), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Short Form 36 (SF-36). The chiropractic treatment group received thoracic chiropractic manipulations (HVLA) twice a week for a total of six sessions over three weeks, while the control group received sham manipulations. A week after the final session, all participants completed the assessments again.


Eligibility Criteria:
Inclusion Criteria:

* Having been diagnosed with fibromyalgia by a doctor.
* Having good cognitive status.
* Willingness to participate in the study voluntarily.
* Being a female aged between 25 and 45.
* The symptoms persisting without any degree of improvement or decrease recently.
* Having dysfunction (limited movement) in the thoracic region.
* Having no condition that would prevent high-velocity low-amplitude (HVLA) manipulation.

Exclusion Criteria:

* Receiving any non-pharmacological treatment.
* Having heart, kidney, or liver failure.
* Having inflammatory, psychiatric, neurological, and/or chronic progressive systemic diseases.
* Pregnancy.
* Having a history of acute or past fractures.
* Malignancy history.
* Having a history of thoracic surgery.
* Having thoracic hernias, radiculopathy, motor deficits spondylosis, spondylolisthesis, narrow canal, extruded hernia, disc herniation, discitis diagnoses.
* Metabolic bone diseases.
* Infection, fever, hypotension, respiratory disorders limiting treatment application.
* Having a rheumatic disease (except osteoarthritis).
* Osteoporosis.
Metabolic Response of Slow Released Carbohydrates in Diabetes Mellitus

The study was conducted

1. to investigate the superiority of isomaltulose in reduction of postprandial hyperglycemia
2. to describe the kinetics of glucose absorption after a load of isomaltulose
3. to demonstrate the safety of a single load of isomaltulose compared to sucrose in type 2 diabetic patients.

Epidemiological studies have shown that postprandial hyperglycemia is associated with atherosclerotic diseases. Therefore, therapeutic strategies to reduce postprandial hyperglycemia are desirable. An effective way to improve postprandial glucose level is the use of carbohydrates with low glycemic index. Isomaltulose is a reducing disaccharide occurring naturally in honey and sugar cane juice, including products derived thereof. It is an isomer of sucrose and composed of glucose and fructose linked alpha-1,6 instead of alpha-1,2.

Isomaltulose has been reported to be digested more slowly than sucrose. Due to this property, lower and slower increases in blood glucose responses are expected for isomaltulose than sucrose. Early studies have demonstrated attenuated glycemic and insulin responses after isomaltulose ingestion than after sucrose. This study was performed to describe the postprandial glucose metabolism more comprehensively after bolus administration of different doses of isomaltulose compared to sucrose in type 2 diabetic patients.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis: type 2 diabetes according to WHO/ADA criteria for more than 1 yr
* Adults aged 18-75 years old
* HbA1c \< 8%, fasting blood glucose \< 140 mg/dl
* For at least 2 months prior to visit 1, subjects must have been on a stable antidiabetic therapy regimen
* Subjects willing to perform home blood glucose monitoring and to otherwise comply with study protocol requirements

Exclusion Criteria:

* Type 1 diabetes mellitus
* Pregnant or lactating women or women planning to become pregnant
* Women who become pregnant will be withdrawn from the study
* Clinically significant heart, liver, lung, or kidney disease
* Drug or alcohol abuse
* Concomitant therapy with systemic glucocorticoids or acarbose
* Subjects unable to adhere to instructions during the qualification phase
Validating Osteoporosis Detection in Rho AI Software

To assess the effectiveness of 16bit's Rho AI (artificial intelligence) software at identifying known cases of osteoporosis. 800 de-identified images from January 2007 to January 2024 will be accessed to test the software prospectively.

Osteoporosis is underrecognized and undertreated in the orthopedic surgery patient population. Osteoporosis is diagnosed by dual-energy x-ray absorptiometry which is costly and imparts radiation. Preoperative radiographs are universally obtained in orthopedic surgery patients, however up to this point radiographs have not been able to diagnose osteoporosis. This software program is a new technology that is able to leverage radiographs to opportunistically screen for osteoporosis.

The study team will identify applicable patient records from medical record review, and Radius will de-identify the x-ray images. The de-identified images will be run through the Rho AI program to identify osteoporosis or osteopenia, and a report will be generated to summarize the program's findings.

Eligibility Criteria:
Inclusion Criteria:

* images from people who have undergone total joint arthroplasty
* images from people who have undergone spine fusion

Exclusion Criteria:

-
Maintaining Patency in BioFlo Implanted Port Catheters With Saline Only Flushes

The purpose of this study is to determine the safest and most effective flushing solution for maintaining patency (unobstructed flow) in BioFlo implanted port catheters. The complication rate in patients whose ports are flushed with saline only will be compared to the complication rate in patients whose ports are flushed with a combination of saline and heparinized saline.

The purpose of this study is to determine the safest and most effective flushing solution for maintaining patency (unobstructed flow) in BioFlo implanted port catheters. The complication rate in patients whose ports are flushed with saline only will be compared to the complication rate in patients whose ports are flushed with a combination of saline and heparinized saline. These complications include partial or complete obstruction, infection of the central line, and/or the onset of heparin induced thrombocytopenia.

Eligibility Criteria:
Inclusion Criteria:

* Able to read and understand English
* Has a BioFlo implanted port in place less than one (1) year
* Evidence of a patent BioFlo port catheter prior to enrollment in the study
* Is receiving active treatment (i.e., receiving a therapeutic drug) through the BioFlo implanted port
* Current treatment protocol projected to continue for a minimum of three (3) months
* Anticipates receiving care at the identified centers for 12 months following enrollment in the study
* Does not receive care of BioFlo implanted port at any other facility

Exclusion Criteria:

* Has documented heparin platelet antibody (i.e., could not be randomized to either group) or other allergy to heparin
* Receiving therapeutic dose of an anticoagulant (e.g.,warfarin, heparin, enoxaparin)
* Does not meet one or more of the inclusion criteria
Effect of Neuromuscular Electrical Stimulation on the Post-Operative Abdominoplasty Patient.

The purpose of this study is to determine the impact of rehabilitative training of the abdominal wall with direct current neuromuscular electrical stimulation (the NEUBIE device) on recovery time from abdominoplasty (tummy tuck).

Participants will undergo abdominoplasty surgery and begin rehabilitation training within the first week post-operation. Standardized measurements of recovery progress will be taken starting prior to operation, and at 2, 4, 6, 8 and 12 weeks post-operation. Participants will undergo either the traditional standard of care of rest, with minimal activity for at least 6 weeks (control group) or a 5 week training course with the NEUBIE (experimental group), starting with passive electrical stimulation in the first week post-operation, and moving towards more advanced abdominal movements accompanied with stimulation in the subsequent four weeks.

Eligibility Criteria:
Inclusion Criteria:

1. Rectus Diastasis
2. Previous pregnancy
3. Excess localized adiposity in the lower abdomen
4. Excess atrophic skin of the abdomen
5. Physician clearance to participate
6. Scheduled for full abdominoplasty (no mini-abdominoplasty included)

Exclusion Criteria:

1. Currently pregnant
2. Cardiac Pacemaker
3. Active or recent cancer in the abdominal area
4. Active or recent blood clots in the abdominal area
5. History of epilepsy