cyrilzakka/clinical-trials huggingface dataset:
The Effect of Brachial Plexus Nerve Block on Distal Peripheral Nerve Conduction

The purpose of this study is to determine the conducting ability of distal extremity nerves after a supraclavicular brachial plexus nerve block (with local anesthetic) has been placed at a more proximal location in the upper extremity.


Eligibility Criteria:
Inclusion Criteria:

* Male and female military health care beneficiaries 18 years and older, capable of providing informed consent indicating awareness of the investigational nature of the study, in keeping with institutional policy
* Written informed consent must be obtained from each patient prior to entering the study
* Patients must be willing to have a regional anesthetic nerve block placed prior to their scheduled procedure
* Patients must be willing to have neurodiagnostic tests performed prior to placement and after placement of the regional anesthesia nerve block

Exclusion Criteria:

* Refusal to have a brachial plexus nerve block placed
* Refusal to have serial nerve conduction studies performed
* Contraindication for a regional anesthesia nerve block (allergy to local anesthetic, infection at site of injection, elevated coagulation time)
* Presence of conditions affecting the hand or arm (e.g., injury, infection) that might preclude the performance of nerve conduction studies
* Presence of known major abnormalities of nerve conduction, e.g., absent median sensory potential in a patient scheduled for carpal tunnel release
* Presence of conditions affecting the contralateral hand or arm (e.g., injury, infection) that might preclude the performance of sensory and motor studies to test block or absence of a contralateral upper extremity
Effects of Overload Progressive in the Treatment of Shoulder

Seventy subjects with shoulder impingement syndrome associated with scapular dyskinesis will be recruited and randomized into two groups of treatment. The group "a" will receive a strenghtening protocol with progressive overload during 20 sessions and group "b" will receive the same protocol with minimal load, without change during the 20 sessions. The primary outcomes measures will be pain, function, quality of life, global impression of recovery. The change will be measure from baseline at 10 weeks (after 20 sessions), 3 and 6 months (follow-up). The secundary outcomes will be disability, quality of life measure by other instruments, shoulder muscle strength and scapular 3d kinematic variables. For these data, change will be measure from baseline at 10 weeks (after 20 sessions).


Eligibility Criteria:
Inclusion Criteria:

* People with diagnosis shoulder impingement syndrome or supraspinatus/rotator cuff tendinopathy or subacromial bursitis
* shoulder pain for more than 4 months, at least 4 points of pain in 0-10 NPRS
* at least 130° shoulder active elevation
* 3 or more positive of 5 physical examination tests (painful arc, external rotation resistence, Neer, empty can (Jobe) and Hawkins-Kennedy
* positive dynamic scapular dyskinesis in clinical observation

Exclusion Criteria:

* Referred pain from vertebral spine
* previous shoulder, elbow or neck surgery
* complete rotator cuff tear (positive drop arm sign or substantial shoulder elevation or rotation weakness)
* neoplastic or neurological disorders
* previous fracture or dislocation injury (shoulder, humerus, clavicle)
* adhesive capsulitis signs
* inflammatory diseases
* specific treatment for the shoulder in the previous four months (injection, physiotherapy)
* using drugs in the previous week
* inability to understand portuguese language
Evaluation of the Effect of a Physical Activity Recovery Stay

A WHO study in 2020 revealed that 81% of adolescents (aged 11-17) do not respect the recommendation of one hour of moderate physical activity per day. In the context of disability, many factors impose limits on physical activity. While the pathology itself induces limitations and restrictions (prolonged sitting time, assisted movement, etc.), organizational constraints also apply to both children and parents, who have to divide their time between work, school and therapeutic care, which is sometimes numerous and varied over the course of a single week. These limitations generate stress and fatigue, and prolonged sedentary periods lead children with chronic illnesses, rare diseases or disabilities into a process of physical deconditioning. The accumulation of sedentary time is detrimental to cardiovascular and metabolic health.

To combat this deconditioning, the 2008 National Physical Activity and Sport Plan (PNAPS) sets out the main guidelines for treatment and implementation. The plan explains that "for patients with chronic illnesses, rare diseases or disabilities, the aim is to encourage care and guidance towards Adapted Physical Activity (APA). The attending physician will be able to identify local therapeutic education programs, rehabilitation services and "sport-santé" offers, to improve access for these patients to supervised local programs". In addition, the plan suggests "developing APA programs in healthcare establishments to enable people with chronic illnesses, rare diseases or disabilities to access health education incorporating practical sessions".

In line with this plan, an exercise reconditioning program has been set up at our facility. This three-month stay includes children with a variety of pathologies, but with a common feature of physical deconditioning.


Eligibility Criteria:
Inclusion Criteria:

* Children with a pathology (chronic disease, rare disease or disability) in a state of deconditioning to exercise
* Taken in charge at the CMPRE for a stay to resume physical activity

Exclusion Criteria:

* Age under 8 and over 18
* Patients undergoing rehabilitation during the stay
* Patients with a significant change in their therapeutic management during the stay
* Significant cognitive impairment preventing comprehension of instructions
* Significant club or leisure sports activity (3x/week)
* Electric wheelchair
* Non-compliance with stay (5 ½ days missed out of total stay)
* Participation in another study during the return-to-physical-activity stay
Effect of Posterior Pelvic Tilt on Balance and Sensory Integration in Patients With Non-specific Low Back Pain

There is a debate in the literature about the effect of NSLBP on pelvic tilt and its effect on balance, sensory integration and functional disability so we need this study to fill the aforementioned gap in literature in this field. So the purpose of the study is to evaluate posterior pelvic tilt effect on overall dynamic balance, sensory integration and functional disability in patients with non-specific low back pain.

The LBP became one of the biggest problems for public health systems in the world during the second half of the 20th century. The lifetime prevalence of LBP is reported to be as high as 84%, and the prevalence of chronic LBP is about 23%, with 11-12% of the population being disabled by LBP. Prevalence of LBP was 53.2%. It was more among female patients (62.8%) than among male patients (38.3%) among attendants to a Family Health Center in Egypt.

Additionally, studies have observed relationships between chronic non-specific LBP and a posteriorly shifted center of gravity, impaired proprioception, and decreased muscular strength, activation and endurance of the trunk and hips. Balance is impaired in individuals with chronic low back pain when compared to healthy individuals.

Most of these studies supposed that postural mal-alignment involves deviations in only one direction which is toward lordosis and anterior pelvic tilt. However, clinical experience suggests that some patients with back pain have the opposite problem which is a much reduced lordotic curve and a posterior pelvic tilt. If the true relationship between posture and low back pain disability is curvilinear instead, this could explain why the studies so far have shown weak or no relationships.

Eligibility Criteria:
Inclusion Criteria:

1. Fifty patients with chronic low back pain or repeated non-specific back pain for more than three months.
2. Both sex with posterior pelvic tilt (-0.7 ± 6.5°)and decreased lumbar lordosis, for (Group A) and normal anterior pelvic tilt angle between 5° and 13° for (Group B)
3. Their ages were ranged from 20-35 years.
4. Body Mass Index from 18-25 Kg/m² .

Exclusion Criteria:

1. Previous back surgery.
2. Signs and symptoms of gross spinal instability.
3. Radiological diagnosis of spondylolysis or spondylolisthesis.
4. Acute low back pain.
5. Disc prolapse or herniation.
6. Any neurological, orthopedic, and vestibular disorders affecting the balance system.
7. Flexion and extension restriction of the lumbar region.
8. Other conditions that affected the normal functioning of the central and peripheral nervous system such as alcohol abuse, addiction, dementia, and cognitive disorders.
Developing and Pilot Testing a Remote Smoking Cessation Digital Therapeutic for Individuals With Serious Mental Illness

This is a pilot randomized clinical trial testing an implementation intervention to support delivery of a smoking cessation app tailored to the needs of those individuals with SMI who at community mental health programs.

Learn to Quit (LTQ), an evidence-based smoking cessation app tailored to the needs of individuals with serious mental illness (SMI) that demonstrated promising smoking cessation outcomes in a recent pilot randomized controlled trial (R00 DA037276). In parallel, several trials demonstrated that widely available social media platforms can be effectively utilized to enhance the effects of standard of care evidence-based smoking cessation treatments. Both approaches capitalize on highly scalable digital technologies, and are therefore likely to have population level impact. Drawing from these two separate programs of research, the central premise of this proposal is that LTQ, a stand-alone smoking cessation app tailored to patients with SMI, can be enhanced with peer-support delivered on social media. Therefore, this proposal seeks to develop and asses the acceptability and feasibility of LTQ-Connect -- the integration of the evidence-based smoking cessation app, LTQ, with social support delivered via social media -- to boost the efficacy and community reach of digital therapeutics tailored for patients with SMI. To achieve this goal, we will:

(1) determine the ideal design requirements of an LTQ-Connect integration among smokers with SMI, and (2) investigate the feasibility of LTQ-Connect in a single group pilot trial. Both interventions will be combined with nicotine replacement therapy, a safe and widely available medication.

Eligibility Criteria:
Inclusion Criteria:

* Must be a mental health consumer at Johns Hopkins Bayview Adult Psychiatry Program
* A regular smoker who is willing to quit
* Own a smart cell phone
* Willing to participate

Exclusion Criteria:

* Women who report being pregnant or have the intention to become pregnant in the 3 months
Evaluation of PK and Biomarkers After UDCA Administrations to Subjects Who Are Overweight and Have Liver Problems

A clinical study to evaluate pharmacokinetics, metabolomics and biomarker in subjects who are overweight and have liver problems after ursodeoxycholic acid multiple administration

This study has a randomized, open-label, three-treatment, one-sequence, placebo-controlled, multiple drug administration design. The purpose of this study is as follows; To evaluate pharmacokinetics, metabolomics and biomarker in subjects who are overweight and have liver problems after ursodeoxycholic acid administration

Eligibility Criteria:
Inclusion Criteria:

* Healthy Subjects aged 18 - 50 years
* A body mass index (BMI) in the range of 25.0 kg/m2 - 30.0 kg/m2.
* A alanine aminotransferase (ALT) in the range of 40 - 200 IU/L
* Good health based on complete medical history, physical examinations, vital signs, electrocardiography (ECG), and clinical laboratory evaluations.

Exclusion Criteria:

* Subjects who have clinically significant disease of cardiovascular, respiratory, renal, endocrinological, hematological, gastrointestinal, neurological(central nervous system), psychiatric disorders or malignant tumor
* Subject judged not eligible for study participation by investigator
Study of Safety and Efficacy of Ceritinib in Combination With Nivolumab in Patients With ALK-positive Non-small Cell Lung Cancer

This is an open label multi center trial to determine the safety and efficacy of ceritinib in combination with nivolumab in ALK-positive NSCLC patients


Eligibility Criteria:
Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of NSCLC that carries an ALK rearrangement
* Stage IIIB or IV NSCLC or relapsed locally advanced or metastatic NSCLC
* Presence of at least one measurable lesion as defined by RECIST 1.1
* Patients who have received prior chemotherapy, other ALK inhibitors, biologic therapy, or other investigational agents, must have recovered from all toxicities related to prior anticancer therapies to grade ≤1 (CTCAE v 4.03). Patients with grade ≤ 2 peripheral neuropathy or any grade of alopecia, fatigue, nail changes or skin changes are allowed to enter the study
* Patient has a WHO performance status 0-1

Exclusion Criteria:

* Presence or history of a malignant disease other than NSCLC that has been diagnosed and/or required therapy within the past 3 years
* Patients with an active, known or suspected autoimmune disease
* Unable or unwilling to swallow tablets or capsules
* Patient has other severe, acute, or chronic medical conditions including uncontrolled diabetes mellitus or psychiatric conditions or laboratory abnormalities that in the opinion of the Investigator may increase the risk associated with study participation, or that may interfere with the interpretation of study results
Effects Aquatic Exercises on Balance and Hand Function in Multiple Sclerosis

This study aims to compare and contrast the effects of two different aquatic exercises on postural control and hand functions in people with multiple sclerosis.

Impaired limits of stability causes falls in people with Multiple sclerosis (pwMS) whereas a well-controlled posture provides improved upper limb functions which are limited in almost 75% of pwMS due to weakness, spasticity or tremor. It is an already known fact that hand dexterity is an indicator of fall risk due to neuromuscular causes and/or abnormalities in the corpus callosum in pwMS.

Aquatic therapy (AT) provides a safe and effective environment for many therapeutic purposes. It is important to understand the effects of each type, intensity, and duration of the aquatic interventions to accomplish most suitable aquatic exercise program.

Halliwick method, neuromotor treatment approach which uses fluid and mechanical properties of water, is based on postural control by mobilizing and controlling body parts through the Ten Point Program.

During Aquatic Plyometric Exercises, proximal part of the body needs to be stabilized to generate a sudden and powerful contraction at the distal part and stabilization of the proximal joints is necessary for maintaining distal movements in a coordinated way.

It is important to understand the effects of each type, intensity, and duration of the aquatic interventions to accomplish most suitable aquatic exercise program. This study aims to compare and contrast the effects of two different aquatic exercises on postural control and hand function.

Eligibility Criteria:
Inclusion Criteria:

* EDSS\>6
* volunteered

Exclusion Criteria:

* Clinical relapse within three months
* incontinence
* persistent infection
Evaluation of the UltraClear Laser Workstation for Skin Treatment - Histology Study of Laser Ablation on Human Skin

Evaluation of the UltraClear Laser Workstation for Skin Treatment - Histology Study of Laser Ablation on human skin

The study is being conducted to evaluate the safety and efficacy of the UltraClear Mid IR Fiber Laser Workstation using both superficial epidermis ablation capabilities and the deep ablative and coagulative capabilities into the dermis. Epidermis is the skin most outer layer that is supported by the dermis, which is the thick layer of living tissue below the epidermis which forms the true skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures. Superficial ablative properties of the laser are the ability to remove thin and controlled layer of epidermis without damaging the underlaying layers of the skin, while the deep ablative properties of the laser are the ability to create a controlled and consistent mechanical and thermal injury in the skin that will lead to strong healing process that will improve the skin properties such as softness, elasticity and appearance. Round ø4.0 mm ( \~ø 1/8") Biopsies will be taken to examine the histologic effects of the treatments.

Eligibility Criteria:
Inclusion Criteria:

-1. Fitzpatrick skin type I-VI. 2. Male or female. 3. Subjects must be between 25 and 75 years of age. 4. Subjects must have ability to get treatment and biopsy from tissue in the abdomen or Buttock.

5. Subjects must read, understand, and sign the Informed Consent. 6. Subjects must be willing and able to comply with all follow-up requirements.

Exclusion Criteria:

1. Subjects must not have active localized or systemic infections.
2. Lidocaine or epinephrine allergy.
3. Subjects must not have a compromised ability for wound healing, such as: malnutrition, steroid use, history of collagen vascular disease (e.g. lupus, scleroderma, history of keloid scar formation), atrophic dermatitis or immunologic abnormalities such as vitiligo.
4. Subjects must not have had treatments with 5FU, hydroquinone, diclofenac, imiquimod, retinoids, or PDT within one month prior to enrollment.
5. Subjects must not currently be taking Accutane, or have taken Accutane within the last 6 months.
6. Subjects must not have a known allergy to the following topical products: lidocaine (numbing cream).
7. Subject must not have used topical steroids or retinoids within the last 3 months on treatment surfaces.
8. Subjects must not have a personal history of malignant melanoma, keloid scars, generalized psoriasis or systemic diseases that would preclude the use of topical anesthesia.
9. Subjects must agree to refrain from using cosmeceutical agents or topical agents during the course of the study, except as directed by study investigators.
10. Subjects must not be pregnant or breastfeeding.
11. Active sunburn or excessively tanned skin

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ADPKD Cohort Study

The purpose of this study is to find out if radiology tests of the kidneys as opposed to glomerular filtration (GFR) tests (GFR test - a lab test that measures kidney function) follow progression of polycystic kidney disease (PKD) the best. PKD patients at risk for progression to renal failure (dialysis or transplantation) have been identified and include those who have been diagnosed with high blood pressure early, the presence of the PKD1 gene (the inherited abnormality responsible for the majority of PKD), men as opposed to women, those with episodes of visible blood or increased protein in their urine, and women who have experience more than three pregnancies. Individuals who are diagnosed with PKD in the first year of life or in utero (before birth) are also at high risk for progression to renal failure.

This study will also facilitate understanding of human diseases at the cellular and molecular level. We will be identifying genetic factors that may influence the severity of polycystic kidney disease (PKD). You are being asked to provide a sample of blood for the purpose of DNA or other biochemical analyses.


Eligibility Criteria:
Inclusion Criteria:

Group 1

* Hypertension diagnosed early in the course of the disease (less than 25 years for men; less than 30 years for women)
* ADPKD diagnosed in utero or in the first year of life
* The presence of proteinuria (between 180 mg and 1 gm/day) without evidence of a second renal disorder
* A history of more than 3 pregnancies and hypertension
* A history of gross hematuria
* A serum creatinine concentration less than 1.4 mg/dl
* ADPKD diagnosed in childhood with more than 10 cysts

Group 2

* Serum creatinine concentration \>1.4 and
* Renal length greater than 15 cm and
* Age less than 60 years of age
* Severe pain or discomfort as assessed by the primary care physician related to ADPKD

Exclusion Criteria:

* Subjects, who in the assessment of the principal investigator cannot provide reliable follow-up
* Subjects who cannot be exposed to iothalamate
* Subjects who cannot undergo MRI due to the presence of a pacemaker or surgical clip in the abdomen
* Subjects who are not anticipated to survive during the duration of the study (e.g. underlying malignancy)
* Subjects who cannot provide informed consent
* Women who are pregnant or who have undergone a pregnancy in the last 6 months or who are presently breastfeeding
Nutrition Education on the Metabolic Syndrome of Subjects Who Are Frequently Eating Out

The project is aimed at investigating the effect of nutrition education on knowledge, attitude and practice (KAP)of subjects who are frequently eating out, and the effect on metabolic parameters.

The project is aimed at investigating the dietary structure and frequencies of eating out via a cross-sectional study, on the basis of which a randomized, parallel controlled trials is to be carried out.The purpose is to evaluate the effect on metabolic parameters.

Hypotheses to be tested:Nutrition education has the effect of improving the metabolic parameters of subjects who are frequently eating out.

Eligibility Criteria:
Inclusion Criteria:

* Shanghai urban citizens
* Male or female 18 to 25 years of age;
* Frequently eat out(eat out 3 or more times per week);
* Clinical diagnosis of Metabolic Syndrome(Meet 3 or more Diagnostic criteria); A. Abdominal obesity: waist circumference\>90cm ( M ), and\>85cm( F ); B. Dyslipidemia:triglyceride≥1.7mmol/L; C. HDL-C \< 1.04mmol/L; D. hypertension: blood pressure≥ 130/85mm Hg ( or have been diagnosed hypertension); E. Hyperglycemia : FPG≥6.1mmol/L and ( or ) 2-hour postprandial blood glucose≥7.8mmol/L and ( or ) have been diagnosed with diabetes;
* Signed written informed consent ;
* Can attend lectures.

Exclusion Criteria:

* Pregnant woman;
* Temporary resident population;
* Participating in another clinical trial 6 months before randomization.
Causes of Nonattendance at Scheduled Outpatient Appointments

Our aim was to identify the causes non-attendance at scheduled appointments at the Clinical Medicine Outpatient care system at the Italian Hospital of Buenos Aires (HIBA).

Nonattendance at scheduled appointments at outpatient clinics is a common problem in general medical practice, representing a significant cost to the health care system, and resulting in disruption of daily work planning.Nonattendance at medical appointments has consequences not only for doctors (as it requires a greater use of resources and time), but also for patients, because there may be deterioration in the quality of care, and dissatisfaction associated with delays in obtaining a new appointment.

Eligibility Criteria:
Inclusion Criteria:

* Over 17 years
* Adults who attended, did not attend and cancelled a scheduled appointment at the Clinical Medicine Outpatient care system at the Italian Hospital of Buenos Aires (HIBA)

Exclusion Criteria:

* Refusal to register or to the informed consent process