cyrilzakka/clinical-trials huggingface dataset:
Detection of Bone Marrow Metastases With Magnetic Resonance Imaging

The goal of this clinical trial is to study the value and feasibility of magnetic resonance imaging in detection of bone marrow metastases

The patient was diagnosed as bone metastasis by pathology. CT showed no bone marrow biopsy site metastasis (anterior iliac spine or posterior iliac spine). After functional magnetic resonance examination, bone marrow biopsy was performed. Functional magnetic resonance imaging includes conventional SE sequence, T2W SPAIR, e-THRIVE,DWI,IVIM. With bone marrow biopsy as the gold standard, the sensitivity, specificity and coincidence rate of functional MRI in the diagnosis of bone marrow metastasis were evaluated.

Eligibility Criteria:
Inclusion Criteria:

1. Patients with malignant tumors (solid tumors or hematological malignancies) were definitely diagnosed by pathology or cytology.
2. patients with bone metastases confirmed by more than two imaging examinations.
3. Age 18-75.
4. ECOG score: 0-2.
5. The expected survival time is more than 3 months.
6. Sign the informed consent.

Exclusion Criteria:

1. Imaging findings suggest that bone metastases are present at the bone marrow puncture site.
2. The patient refused bone marrow puncture.
3. Puncture site with infection.
4. Severe coagulation dysfunction.
5. There are implanted instruments in the body, so magnetic resonance imaging can not be performed.
Ultrasonic Measurement of IVC and IJV in Predicting Hypotension After Anesthesia Induction

This research is expected to study ultrasonic measurement of internal jugular vein and inferior vena cava, which can be used as a good index to predict hypotension after anesthesia induction, and its measurement method is simple and quick.

The induction of anesthesia is the process from the physiological state to the anesthetic state in a short period of time. Hypotension after anesthesia induction is closely related to many organ injuries. Gastrointestinal surgery patients' prohibition of fasting is an important mechanism of severe hypotension after anesthesia induction. At present, ultrasonic measurement of inferior vena cava and internal jugular vein has been proved to be a convenient and non-invasive means to evaluate patients' blood volume. The purpose of this research was to study the relativity between ultrasonic measurement of inferior vena cava and internal jugular vein and hypotension after anesthesia induction in patients.

Eligibility Criteria:
Inclusion Criteria:

* Gastrointestinal surgery
* BMI 18\~24
* ASA score gradeⅠ\~ III

Exclusion Criteria:

* anemia
* cirrhosis
* Emergency surgery
* severe hypertension
* New York Heart Association III \~ IV or ejection fraction \<40%
* cirrhosis
* Other serious systemic diseases
Effects of Mulligan Bent Leg Raise With and Without Bowen Therapy on Hamstring Tightness in Asymptomatic Adults

Hamstring tightness is a common problem caused by a sedentary lifestyle and can have negative effects on posture and musculoskeletal function. It can lead to postural misalignment, increasing loading on the lumbar spine, increased pressure on inter-vertebral disc and potentially resulting in low back problems. Bowen technique and Mulligan Bent leg raise is used to treat conditions including hamstring tightness.

The goal of this clinical trial is to compare the effects of mulligan bent leg raise with and without Bowen therapy on hamstring tightness in asymptomatic adults.

A randomized control trial will be conducted at Riphah Rehabilitation Center and Physiogic Physiotherapy clinic on 50 asymptomatic adults who meet the inclusion criteria will be recruited using non probability purposive sampling and randomly allocated using Random Allocation Software 2.0. Informed consent will be obtained from all participants. They will be divided into two groups which will contain 25 participants in each group. Group A will receive three alternate sessions of Mulligan Bent Leg Raise with Bowen therapy and Group B will receive three alternate sessions of Mulligan Bent leg Raise. The Mulligan Bent Leg Raise technique will be performed with 3 repetition, 3-4 times with 20 sec hold and one minute rest between each repetition.

Eligibility Criteria:
Inclusion Criteria:

* Male/Female
* Age group between 18-40 years
* Unilateral limitation of SLR less than 75 degrees
* Asymptomatic, active knee extension less than 160 degrees

Exclusion Criteria:

* Fracture of Lower limb
* Individuals with soft tissue injury
* Chronic back pain
* Prolapsed Intervertebral disc
* Any surgery was done for back, pelvis hip or knee.
* Spinal deformity
Transforming Care and Payment Priorities for Vulnerable Families

This will be a randomized control trial of 800 children admitted to the Pediatric Hospital Medicine service at Texas Children's Hospital. Each eligible participant will give informed consent prior to enrollment. Study participants will be randomized into an intervention (400 participants) or control group (400 participants). The intervention group will receive a survey (WE CARE HOUSTON) that has been designed to assess family need for community resources that address the SDH (such as food insecurity, housing insecurity, etc.). The intervention group will receive referrals to community resources based on their responses to the WE CARE HOUSTON survey.

This will be a randomized control trial of 800 children admitted to the Pediatric Hospital Medicine service at Texas Children's Hospital. Each eligible participant will give informed consent prior to enrollment.

Study participants will be randomized into an intervention (400 participants) or control group (400 participants). The intervention group will receive a survey (WE CARE HOUSTON) that has been designed to assess family need for community resources that address the SDH (such as food insecurity, housing insecurity, etc.). The intervention group will receive referrals to community resources based on their responses to the WE CARE HOUSTON survey. The intervention group will receive a phone call within 3 months of discharge to ask if they have had trouble following up with resources.

Both the intervention and the control groups will be followed for 6 months. Study investigators will obtain outcome data through structured telephone interviews at 6 months and also through medical record review.

This research has been designed to test our hypotheses:

1. The use of the WE CARE HOUSTON screening tool and subsequent referral to community resources will result in increased family participation in community resources that address the SDH; i.e. we believe that the intervention group will enroll in more community resources than the control group over the 6 month study period.
2. The use of the WE CARE HOUSTON screening tool and subsequent referral to community resources will result in improved health outcomes, i.e. children in the intervention group will have fewer emergency department visits, fewer readmissions, improved BMI and improved parent perception of child's health during the study period.

Eligibility Criteria:
Inclusion Criteria:

* Children admitted to pediatric hospital medicine service

Exclusion Criteria:

* Children in child protective service custody
* Children residing outside of the greater Houston area
Clinical Performance Study of Safety Test ABO Device

The study aims to confirm the performance equivalence of the in vitro diagnostic device Safety Test ABO with the ABTest Card device.

According to the regulatory text "Common specifications for certain class D in vitro diagnostic medical devices in accordance with Regulation (EU) 2017/746 of the European Parliament and of the Council" \[2\], 90% of the results will be derived from the performance study carried out at the DIAGAST laboratory on tube left over and blood bag, and 10% of the results will be derived from the use of the device in a real situation ("at the bedside").

Regulation 2017/746 (IVDR) on IVDMD has been effective since May 2022 with transitional periods. The IVDR replaces the current EU Directive (98/79/EC) to ensure a higher level of health and safety for the making available and putting into service of medical devices on the EU market. As the Safety Test ABO and ABTest Card® are already CE marked under Directive 98/79/EC as List IIA product, this study is part of the device's post-marketing performance monitoring.

Eligibility Criteria:
Inclusion Criteria:

* Age ≥ 18 years old for the category marked with \*.
* Undergo capillary blood sampling;
* Belong to one of the clinical category:

  * Patient in need of blood transfusion without any pathology known to have an impact on transfusion act\*;
  * Patient in need of blood transfusion suffering from congenital erythrocyte pathology (sickle cell anaemia, beta thalassemia)\*
  * Patient in need of blood transfusion suffering from haematology disease (eg. cancer), or undergoing haemodialysis\*;
  * Patient with cold agglutinin\*;
  * Premature patient with gestational age \< 37 weeks of newborn ≤27 days old in need of blood transfusion;
  * Newborn eligible for Guthrie Test;
  * Newborn eligible for glycemic test.
* Have health care insurance;
* Have given his/her written consent (or legal representative in case of newborn);

Exclusion Criteria:

* Pregnant woman;
* Person deprived of liberty;
* Unconscious person;
* Person under guardianship or trusteeship;
* For neonatal clinical category: age ≥28 days and \<18 years old.
Individualized Chiropractic and Integrative Care for Low Back Pain

This study proposes to compare two innovative treatment approaches for LBP, both of which focus on delivering individualized care through evidence-based, clinical care pathways.

The primary aim of the project is to determine the relative clinical efficacy of 1) chiropractic care and 2) multidisciplinary, integrative care in 200 patients with sub-acute or chronic LBP, in both the short-term (after 12 weeks) and long-term (after 52 weeks). The primary outcome measure in this study is patient-rated back pain.

Chiropractic care will include therapies within the professional scope of practice. Integrative, multidisciplinary care will include chiropractic, massage therapy, traditional Chinese medicine (including acupuncture), medication, cognitive behavioral therapy, exercise, and patient education.

Secondary aims are to assess between group differences in frequency of symptoms, disability, fear avoidance behavior, self efficacy, general health, improvement, patient satisfaction, work loss, medication use, lumbar dynamic motion, and torso muscle endurance. Patients' and providers' perceptions of treatment will be described using qualitative methods and cost-effectiveness and cost utility will be assessed in the short- and long-term.

This innovative study is an exciting collaboration between an experienced and established team of chiropractic, conventional, and CAM professionals dedicated to advancing the care of pervasive and costly LBP conditions. This trial will provide new and important information for all health care providers and LBP patients, informing decision making and improving care delivery systems.


Eligibility Criteria:
Inclusion Criteria:

* Mechanical LBP classified as 1, 2, 3, or 4 using Quebec Task Force (QTF) classification.70 (This includes back pain, stiffness or tenderness with or without musculoskeletal and neurological signs).
* LBP localized to posterior aspect of body, below the costal margin and above the inferior gluteal folds.
* Pain level \> 3 on 0 to 10 scale
* Current LBP episode \> 6 weeks duration
* 18 years of age and older
* Stable prescription medication plan (No changes in prescription medications that affect musculoskeletal pain in the previous month.)

Exclusion Criteria:

* Ongoing treatment for LBP by other non-study providers
* Progressive neurological deficits or cauda equina syndrome
* QTF classifications 5 (spinal instability or fracture) and 11 (other diagnoses including visceral diseases, compression fractures, metastases). These are serious conditions not amenable to the conservative treatments proposed.
* QTF 7 (Spinal stenosis syndrome characterized by pain and/or paresthesias in one or both legs aggravated by walking).
* Uncontrolled hypertension or metabolic disease
* Blood clotting disorders
* Severe osteoporosis
* Inflammatory or destructive tissue changes of the spine
* Patients with surgical lumbar spine fusion or patients with multiple incidents of lumbar surgery. This is a subgroup of LBP patients which generally have a poorer prognosis.
* Pregnant or nursing women
Droplet-digital PCR for the Detection of Circulating Cell-free DNA in Patients With Cystic Echinococcosis: an Exploratory Study

It is an experimental study, multicentre, non-profit, whose aim is to preliminarily evaluate the sensitivity of ddPCR for the detection of cfDNA in the diagnosis of cystic echinococcosis and to generate data for its potential use also for the discrimination of the presence of infection with active/inactive cysts and the post-therapy follow-up.

It is an experimental study, multicentre, non-profit, whose aim is to preliminarily evaluate the sensitivity of ddPCR for the detection of cfDNA in the diagnosis of cystic echinococcosis and to generate data for its potential also use for discrimination of the presence of infection with active/inactive cysts and follow-up aftercare, to be explored in subsequent studies. For this purpose, the plasma of adult patients with untreated hepatic cystic echinococcosis will be analysed.

The analyzes will be carried out on samples of patients who have already had a definitive diagnosis of cystic echinococcosis, and therefore the results of the study analyzes will have no influence on the diagnosis and clinical management of the patient, which, therefore, will not be informed of the result of the analyzes relating to his/her sample.

Eligibility Criteria:
Inclusion Criteria:

1. age ≥18 years;
2. definite diagnosis of hepatic cystic echinococcosis, ascertained on the basis of the presence of at least one liver cyst with pathognomonic signs on ultrasound examination or the presence of at least one liver cyst without clearly visible pathognomonic signs but presence of positive serology with at least two validated commercial tests or western blot (LDBIO Diagnostics, Lyon, France) positive for anti-Echinococcus antibodies (WHO-IWGE diagnostic criteria, Brunetti et al 2010);
3. no prior therapy for cystic echinococcosis reported;
4. willingness to participate in the study by signing the Informed Consent form.

Exclusion Criteria:

1. age \< 18 years;
2. unconfirmed diagnosis of cystic echinococcosis; Echino_ddPCR version 1.1 of 02/14/2022
3. presence of echinococcal cysts only in extra-hepatic localization;
4. history of treatment for cystic echinococcosis.
Salivary Transcriptome Biomarkers for Early Diabetes Detection

A PRoBE design study will be used to obtain saliva from patients before undergoing blood study evaluation for screening at risk patients for the presence of undiagnosed pre-diabetes of type II diabetes. Pre-specified saliva biomarkers will be evaluated along with multi-marker models for their discriminatory value for distinguishing patients with normal glucose metabolism from those with disease. Appropriate housekeeping genes will also be incorporated to allow for the measurement of relative gene expression.

Prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) methods will be employed to collect saliva and evaluate transcriptome markers for early pre-diabetes and type II diabetes identification. At risk patients will have fasting blood glucose and insulin levels measured along with hemoglobin A1c and 2 hour post-prandial glucose levels. Saliva samples will be stored and will be analyzed after pre-specifying a panel of mRNAs and a multi marker model for validation. The pre-specified mRNAs and multi-marker model will be determined after analysis of data from a currently ongoing case-control study. After analyzing the data from this prior trial a validation plan will be locked before analysis of the prospectively collected specimens. Pre-diabetes will be defined based on abnormal glucose tolerance tests. Insulin resistance will be calculated as HOMA IR. The diagnostic value of the salivary transcriptome for will be compared with that of hemoglobin A1c and fasting blood glucose for the detection of pre-diabetes, insulin resistance and type II diabetes.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients with unknown glucose metabolism status and
* Requiring clinically driven screening for abnormal glucose metabolism and
* Outpatient status

Exclusion Criteria:

* Patients on treatment for abnormal glucose metabolism including diet and drug therapy
* Patients with a prior diagnosis of abnormal glucose metabolism
* Patients on treatment with corticosteroids
Better Breaks: Strength Breaks vs Walk Breaks for Sedentary Behavior Breaks

This study investigates the benefits of two different types of 2 minute activity breaks during sedentary workdays for people who sit for long periods of time in sedentary jobs.

For this study, participants are randomly assigned to one of two physical activity breaks and for 8 weeks are to do 4 per day and track their daily breaks and productivity. There are many measurements including: in-person strength assessments at baseline, 1 month, and 2 months; daily tracking of breaks; pre and post oral glucose tolerance tests; pre and post 10-day diet tracking; pre and post 10-day Continuous Glucose Monitoring with a Dexcom; genome with saliva at pre; and -omics at pre and post.

Eligibility Criteria:
Inclusion Criteria:

-

Identify inclusion criteria.

1. Sedentary occupation (e.g., clerical work, data entry, call center, receptionists)
2. Full time employment remote or on-site
3. Able to safely perform bodyweight squats and lunges
4. Over 30 years old
5. Not currently doing a strength training program
6. Not currently taking planned activity breaks at work
7. Has a smart phone with a camera and unlimited text plans
8. Interested in participating
9. Fluent in English
10. Not currently on insulin or any glucose lowering medication

Exclusion Criteria:

1. Yes to any of the physical activity readiness criteria questionnaire (e.g. cardiac symptoms with increasing heart rate, dizziness upon performing exercise)
2. Participating in another research study on diet, weight loss, or any physical activity.
3. If their doctor has ever said to not strength train
4. Having insulin dependence
Transcatheter Arterial Chemoembolization With KMG Microsphere Treating Advance-stage Hepatocellular Carinomas (TACE-KMG)

The purpose of this study is to evaluate the effects of Transcatheter Arterial Chemoembolization (TACE) with KMG microsphere in treating HCC. And to determine which one is better,KMG microsphere or lipiodol?

The most important part of effect in TACE is embolization .But there is no clinical trials on which one is better,KMG microsphere or lipiodol? what effect did chemo play in the TACE treating HCC? Which one is better,routine dose or low dose? Experts in USA and Japan had their own researches and standpoints.We think it is important to push a clinical trail to answer these problem.

Eligibility Criteria:
Inclusion Criteria:

* Hepatocellular Carinomas with diagnosis of pathology or cytology or consistent with China 2001 guideline of Clinical Diagnosis Hepatocellular Carinomas clinical stage（The Barcelona Liver Clinic staging system,BCLC B and C)，or can not receive surgical intervention
* liver function:Child-Pugh A、B
* PST 0-1（Eastern Cooperative Oncology Group Performance Score ,ECOG）
* Lifespan≥6 months
* First time to receive treatment
* Can accept the follow up
* informed consent was gotten
* the number of lesion ≤ 5

Exclusion Criteria:

* pregnant or lactation woman
* emotional disturbance
* serious heart ,lung disfunction or serious diabetes mellitus
* serious reactiveness infections;（exp:type B or C hepatitis）
* liver function :Child-Pugh Score C
* thrombocyte\<6×109/L
* diffuse HCC
* widespread metastasis
* serious atherosclerosis
* acquired immunodeficiency syndrome;AIDS
* thrombosis or thrombosis event in 6 months
* renal inadequacy who need hemodialysis or peritoneal dialysis
* with other tumors except basal cell carcinoma and carcinoma in situ of cervix
* serious alimentary tract hemorrhage in 4 weeks
Pilot Internet-based Self-Help Program for Managing Corona (COVID-19) Stress

The current study examines an adapted guided self-help stress reduction program, focusing on reducing stress in the time of COVID-19. Two studies are planned: 1) an international study in English in which individuals proficient in English throughout the world will participate and 2) a follow-up study in Hebrew.

The current study examines an adapted guided self-help stress reduction program, focusing on reducing stress in the time of COVID-19. Two studies are proposed: 1) an international study in English in which individuals proficient in English throughout the world will participate and 2) a study in Hebrew. The first study will publicize via social media and participants will be randomized to either immediate participation or a 6 week waitlist period. Assessments will be conducted pre, (again after waitlist for the control group), posttx (after completion/cessation of the program), 6 month and 1 year followup. Two forms of assessment will be conducted: pre-post-follow-up (with the CRISIS measure) and weekly during the program (via the DASS-21). For the full program see: https://www.iterapi.se/sites/coronastress/

Eligibility Criteria:
Inclusion Criteria:

* Read/Write English,
* feels stress due to Corona/COVID-19

Exclusion Criteria:

* current psychological or psychiatric treatment,
* current psychiatric illness,
* suicidality,
* psychosis,
* bipolar,
* severe dissociative symptoms,
* in a currently severe traumatic situation,
* having a serious medical illness.
Learning Curve for Robot-Assisted Gastrectomy in Gastric Cancer

The investigators prospectively collected the clinical data of Da Vinci robot-assisted radical gastrectomy patients conducted by the same group of physicians from October 2017 to October 2018. The learning curve of the surgery was analyzed with the moving average method and the cumulative sum analysis (CUSUM). The short-term efficacy was then validated by comparing the perioperative and pathologic outcomes of patients in the two stages of the learning curve.


Eligibility Criteria:
Inclusion Criteria:

* 1.Patients were 18-90 years old
* 2. Patients with a documented diagnosis of gastric adenocarcinoma
* 3. patients were scheduled to undergo minimally invasive gastric cancer surgery
* 4.patients with no preoperative evidence of serosal invasion or extraperigastric lymph node metastasis on preoperative computed tomography scans, upper endoscopy, and endoscopic ultrasound

Exclusion Criteria:

* 1. Patients with neoadjuvant treatment
* 2. Patients procedure concurrent with the gastrectomy
* 3.Patients with palliative surgery
* 4. Patients with the contraindications for general anesthesia
* 5. Patients were pregnant or mentally incompetent
* 6. Patients with serious systemic comorbidities, such as severe heart failure, respiratory failure, uncontrolled hypertension