cyrilzakka/clinical-trials huggingface dataset:
Suture Granuloma in Body Contouring Surgery

The purpose of this study is to evaluate the effect of different suture material on the incidence of suture granuloma.

Bariatric surgery has evolved as an effective treatment for morbid obesity, inducing rapid and predictable weight loss within a period of 12 to 18 months following surgery. Consequently, body contouring after weight loss is emerging as the fastest growing field of plastic surgery. Patients seek consultation with a plastic surgeon to correct skin laxity of the abdomen, thighs, chest, back, and neck.

A major problem in body contourinig is the extrusion of absorbable suture material used for dermal closure. Long incisions and high tension inherent to body contouring surgery mandate a secure dermal closure. While absorbable sutures are preferred, they can result in suture granuloma and extrusion.

Eligibility Criteria:
Inclusion Criteria:

Men and women 18 years and older

Exclusion Criteria:

Subjects with active infectious collagen disease,significant anatomic asymmetry that creates markedly different wound tension and/or geometry between left and right side Subjects who cancel their surgery
CPR Feedback Devices

The aim of the study was to compare two methods of training in CPR, standard basic life support and CPR using CPR feedback device.


Eligibility Criteria:
Inclusion Criteria:

* Give voluntary consent to participate in the study

Exclusion Criteria:

* Not meet the above criteria
* Wrist or low back diseases
Narrative Medicine for Improving Well-Being in Patients With Gastrointestinal Cancers

This clinical trial assesses whether narrative medicine methods may improve the sense of well-being among gastrointestinal (GI) (digestive system) cancer patients. Narrative medicine is a clinical approach where providers can use a patient's own narrative (perspective) of their illness to promote healing and resilience. By applying narrative medicine's main tool, close reading, to clinical practice, clinicians learn to listen and attend to patients more deeply. This allows for freer communication and the creation of a healthcare encounter that centers on the psychological and emotional well being of the patient in addition to their medical conditions. Narrative medicine can include close reading, creative or reflective writing, and discussion. These methods may help patients with GI cancer to reflect on their life stories, both inside and outside of their illness experience, and help them gather skills to optimize their well-being.

PRIMARY OBJECTIVES:

I. To assess the feasibility of implementing narrative medicine tools in serial workshops with patients with malignancy.

II. To determine if narrative medicine interventions improve markers and expressions of well-being.

DESCRIPTIVE OBJECTIVES:

I. To estimate changes in markers and expressions of well-being after 3 sessions of narrative medicine intervention.

II. To determine, through qualitative methods, if patients find benefit from the intervention regarding their well-being.

III. To decide whether to expand these kinds of interventions to a larger study with control group.

OUTLINE:

Patients participate in narrative medicine sessions over 60 minutes once every 2 weeks (Q2W) for 3 sessions.

After completion of study intervention, patients are followed up at 1 and 3 months.

Eligibility Criteria:
Inclusion Criteria:

* Patients with diagnosis of gastrointestinal malignancy actively receiving infusional therapy for cancer.
* Age \>= 18 years.
* English speaking with ability to participate in reading and writing questionnaires and implementation tools.
* Performance Status =\< Eastern Cooperative Oncology Group (ECOG) 3.

Exclusion Criteria:

* Altered mental status or other cognitive impairment, organic or drug induced that would limit ability to participate in the evaluation.
Rehabilitation After Arthroscopic Partial Meniscectomy

Water-Based vs. Land-Based Rehabilitation After Arthroscopic Partial Meniscectomy in Middle-Aged Active Patients with a Degenerative Meniscal Tear: A Randomized, Controlled Study

In this study, we aimed to determine and compare the benefits of water-based exercise (WBE) and land-based exercise (LBE) on pain, functionality, and quality of life after arthroscopic partial meniscectomy (APM). Middle-aged (35-50), active 30 patients having APM for a degenerative meniscal tear randomized into LBE (n=15) and WBE (n=15) groups. The pain level (visual analogue scale \[VAS\]), isokinetic muscle strength, quality of life (Short Form-36 \[SF-36\]), and function level (single-leg hop test and Lysholm questionnaire) were evaluated prior to treatment and at follow-up visits at the fourth and eighth week after surgery. The exercise sessions were conducted 3 times a week for 4 weeks in both groups.

Eligibility Criteria:
Inclusion Criteria: The inclusion criteria comprised a non-locked painful knee of more than 1 month, age between 35-50 years, a clinical history and examination compatible with degenerative meniscus, positive findings of a degenerative meniscal tear visible with magnetic resonance imaging (MRI), no response to nonoperative treatment of at least 3 months after onset of symptoms, and no evidence of advanced osteoarthritis (OA) on X-rays or MRI

Exclusion Criteria: The exclusion criteria employed were advanced knee OA, systemic inflammatory disease, a concurrent tear of posterior cruciate ligament, a concurrent collateral ligament repair, other problems causing knee pain (e.g., hip and ankle pathologies), a history of cardiopulmonary disease that could limit isokinetic and functional testing, an unstable medical condition, a serious cognitive deficit, a psychiatric problem, no capacity for independent walking and standing, an open wound on the skin, or pregnancy
Reintervention-study After Previous Renal Denervation in Non-responding Patients With Severe Hypertension

The purpose of this study is to determine the effect of repeated renal denervation in non-responding patients with severe hypertension. Therefore ultrasound technique will be used.

Renal Denervation is a CE-certified opportunity for treating patients with therapy-refractory hypertension. In some patients it doesn't show a significant lowering of the blood pressure, so a repeated renal denervation is an option.

In this study repeated renal denervation will be performed with the Recor Paradise Ultrasound Catheter.

For the study no specific procedures are required which would exceed the standard renal denervation procedure with the CE-certified Recor Paradise Ultrasound Catheter System.

There are no additional risks for the patient in consequence of participating in the study or the follow up procedures.

Eligibility Criteria:
Inclusion Criteria:

* Individual is ≥18 years old
* Individual received renal denervation ≥12 months prior to study participation to no therapeutical avail and is scheduled for reintervention.
* Systolic Office based blood pressure ≥140mmHg
* Individual receives 3 or more antihypertensive drugs including one diuretic
* Individual is willing to provide written informed consent to participate in this study

Exclusion Criteria:

* Individual has hypertension secondary to an identifiable and treatable cause
* Individual has any serious medical condition which in the opinion of the investigator may adversely affect the participation.
* Individual is pregnant, nursing or planning to be pregnant
* Renal artery abnormalities which may affect the procedure
The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged times of pneumoperitoneum. Therefore investigators decided to evaluate the impacts of surgical visibility through deep neuromuscular blockade on intraocular pressure in patients undergoing Robot-Assisted Laparoscopic Radical Prostatectomy.


Eligibility Criteria:
Inclusion Criteria:

1. ASA class I-II
2. obtaining written informed consent from the parents
3. aged over 50 years who were undergoing robot- assisted laparoscopic prostatectomy

Exclusion Criteria:

1. eye surgery previously
2. unstable angina or congestive heart failure
3. concomitant eye disease (glaucoma, diabetic retinopathy, cataract, retinal detachment)
4. high intraocular pressure over 30mmHg after screening test.
5. uncontrolled hypertension (diastolic bp\>110mmHg)
6. coagulopathy
7. asthma
8. hepatic failure
9. renal failure(creatinine clearance \< 30 ml/min)
10. drug hyperactivity
11. neurological or psychiatric illnesses
12. mental retardation
13. patients who can't read the consent form due to illiterate or foreigner
14. previous malignant hyperthermia Hx
15. drug medication which interact with muscle relaxant (anti-convulsant, certain antibiotics, magnesium etc)
16. BMI \> 30kg/m2
Rifaximin Therapy vs Low FODMAP Diet In IBS

Functional gastrointestinal disorders (FGIDs) are common and from the most recent global epidemiology study, an estimated 40% of the world population suffer from the condition. FGIDs cause significant morbidity to patients, despite not influencing mortality. IBS is among the most important functional gastrointestinal disorder with an estimated 3.8 to 9.2 % of the general population worldwide were affected by this disorder.

Rifaximin (gut specific antibiotic) and low FODMAP diet (dietary based therapy) were proven to be effective in treating irritable bowel syndrome (IBS), however there was no head-to-head study comparing both treatments. This study will help doctors to understand the efficacy of different IBS/SIBO treatments. With the evaluation of factors that can predict treatment response, doctor could potentially treat IBS and SIBO more effectively in future.

The purpose of the study is to compare the clinical symptoms and psychological improvement in patients with irritable bowel syndrome (IBS) after treatment with Rifaximin versus treatment with low FODMAP diet. The factors that is associated with treatment response will also be evaluated. In IBS patients with small intestinal bacterial overgrowth (SIBO), eradication rate of SIBO will be evaluated.


Eligibility Criteria:
Inclusion Criteria:

1. Patients diagnosed with Irritable bowel syndrome using Rome III diagnostic criteria with Abdominal Pain/ Discomfort Intensity of weekly average of worst abdominal pain/ discomfort in past 24 hours score of ≥ 3.0 on a 0 to 10 point scale AND Stool Consistency of at least 2 days per week with at least one stool that has a consistency of Type 6 or Type 7 BSS or \<3 CSBM per week
2. Subject who can provide written informed consent and willingness to comply with the requirement of the protocol
3. Able to communicate in English, Malay, or Mandarin languages

Exclusion Criteria:

1. Patients with known hypersensitivity or contraindication to Rifaximin
2. Pregnant / breastfeeding women
3. Patients who are on probiotics for the past 1 month
4. Presence of family history of GI malignancy or alarm features suggested malignancy - e.g. Unintentional weight loss (≥ 10% of body weight in recent 6 months), GI bleeding
5. History of gastrointestinal (GI) malignancy
6. Patients with any hepatobiliary or pancreatic diseases
7. Patients with severe depression, anxiety, or other psychological disorder
8. Patients with any terminal disease
9. Other conditions determined by the investigator to be inappropriate for this clinical study
The Impact of Green Spaces on the General Well-being and Stress of Students

The number of students with psychological problems is on the rise, due to a combination of increasing performance pressure, high expectations, difficulties handling stress, social pressure, and studying. Spending time in a green space has been shown to have positive effects on the mental and general health. This project aims to alleviate the symptoms of mental fatigue and stress related disorders such as burn out in students by offering a nature-based activity.

Participants are asked to take a thirty-minute walk in a nature-based area for five consecutive days, followed by a control period (regular schedule of the participant) for five days, or vice versa. The investigators test stress-related parameters including concentration tests, cognitive tests, cortisol levels, and cardiovascular measurements.

This project aims study the effectiveness of nature-based solutions on the prevention of stress-related symptoms due to high study pressure in students. A nature-based physical activity is recommended once a day to prevent stress build-up and positively influence the cardiovascular system. Participants are randomized into two groups: the first group of participants are asked to walk a nature-based route near the University campus for thirty minutes per day for two weeks (phase 1). After each activity-based phase, a washout period of one week is implemented to avoid carry-over of results (phase 2 and 4). In the third phase, the participants are asked to resume their daily activities for two weeks (control). The second group undergo the same phases but reversed: participants start with two weeks of their usual daily activities, followed by two weeks of nature-based activity. After each phase, the investigators measure neurocognition through neurocognitive tests, the emotional status through detailed questionnaires and assess stress levels through cardiovascular measurements, including salivary cortisol levels of saliva collected upon awakening, 30 min after waking and at 8 pm.

Eligibility Criteria:
Inclusion Criteria:

* Student of Hasselt university or university college PXL and dutch speaking

Exclusion Criteria:

-
Strategy + RehaCom for Memory Rehabilitation in Traumatic Brain Injury (TBI)

The purpose of this research study is to evaluate the effectiveness of "RehaCom," a computerized treatment for memory deficits, in a 16-session, interactive course. Following a manualized approach, the Rehacom modules will be used for the repeated application of the content acquired during 1-on-1 memory strategy training. The goal is to improve face/name, list and verbal memory of patients who survived a moderate to severe traumatic brain injury.

This randomized clinical trial (RCT) consists of 20 chronic moderate-to-severe TBI patients who will receive memory strategy training and complete three memory modules of the RehaCom at one of the Kessler Foundation locations. Changes in attention, processing speed, verbal/non-verbal new learning and memory (NLM) and executive control will be assessed via pre/post and 3-month follow-up assessments before and after the 8-10 week intervention. Self-report questionnaires will also track functional and emotional outcomes such as mood and anxiety, cognition, quality of life, self-efficacy, deficit awareness, community participation, and readiness for occupational functioning

Eligibility Criteria:
Inclusion Criteria:

* Able to read and speak English fluently at the 5th grade level (for testing; software has multilingual support)
* Had a TBI at least 1 year ago
* No history of learning disorders during school years
* Able to use a personal computer (PC) non-stop for 1 hour without health or visual complaints; able to press keyboard buttons.No history of learning disorders

Exclusion Criteria:

* Actively participating in another intervention study
* Distance to Kessler Foundation East Hanover or West Orange location is more than 20 miles.
Comparative Study of the TOMEY Specular Microscope EM-4000 and the Konan CellChek XL

The Tomey EM-4000 Specular Microscope is designed to observe and analyze corneal endothelium.

The Tomey EM-4000 Specular Microscope is designed to observe and analyze corneal endothelium by capturing an image of corneal endothelium tissues. without making contact, analyzing the captured image, and calculating data such as cell density.

Eligibility Criteria:
Inclusion Criteria-Non-pathologic young adults (18-28 years old) and non-pathologic adults (29-80 years old)

1. Male or female subjects from 18 to 80 years old who have full legal capacity to volunteer on the date the informed consent is signed;
2. Subjects who can follow the instructions by the clinical staff at the clinical site, and can attend examinations on the scheduled examination date;
3. Subjects who agree to participate in the study.

Inclusion Criteria -Pathologic adults (29-80 years old):

1. Male and female subjects from 29 to 80 years old who have full legal capacity to volunteer on the date the informed consent is signed;
2. Subjects who can follow the instructions by the clinical staff at the clinical site, and can attend examinations on the scheduled examination date;
3. Subjects who agree to participate in the study;
4. At least one eye with any of the following conditions:

   1. History of post-op surgical trauma including pseudophakic or aphakic bullous keratopathy
   2. History of corneal transplant
   3. Physical injury or trauma to the cornea
   4. Fuch's dystrophy, Guttata or other corneal endothelial dystrophies
   5. Keratoconus
   6. Long-term polymethyl methacrylate (PMMA) contact lens use (greater than 3 years).

Exclusion Criteria - Non-pathologic young adults (18-28 years old) and non-pathologic adults (29-80 years old)

1. History of post-op surgical trauma including bullous keratopathy;
2. History of corneal transplant;
3. Evidence of physical injury or trauma to the cornea;
4. Fuch's dystrophy, Guttata or other corneal endothelial dystrophies;
5. Keratoconus;
6. Long-term PMMA contact lens use (greater than 3 years);
7. History of cataract, refractive or ocular surgical procedures that render the cornea opaque or otherwise impact its ability to be imaged using the investigational device;
8. Fixation problems which may prevent obtaining good Tomey EM-4000 and Konan CellChek XL images in either eye.

Exclusion Criteria - Pathologic adults (29-80 years old)

1. History of cataract, refractive or ocular surgical procedures that render the cornea opaque or otherwise impact its ability to be imaged using the investigational device;
2. Fixation problems which may prevent obtaining at least poor quality Tomey EM-4000 and Konan CellChek XL images in either eye.
Optical Biopsy and Fallopian Tube

High-grade serous ovarian cancer is the most threatening type of gynaecological cancer with an important mortality due to late diagnosis. However the prognosis is excellent in the early stages of the disease. Recently it has been described a new serous carcinogenic sequence from the fallopian tube with tubal precancerous lesions. Therefore the identification of these early preinvasive lesions would be of great interest in the population with hereditary predisposition for ovarian cancer (concept of oncofertility) and in the general population (to determine whether bilateral salpingectomy has to be performed during a hysterectomy for benign disease).

The optical biopsy has been developed and validated in the detection of early precancerous lesions (such as Barrett's oesophagus or in situ cancer of the bladder). The first objective of this study is to prospectively assess the efficacy of optical biopsy (Cellvizio®) in the study of fallopian tubes during laparoscopy with correlation between the histopathological and immunohistochemical analysis and the endomicroscopy image interpretation. The second objective is to describe the optical biopsy pictures in order to state a classification.

Inclusion Criteria:

* Woman aged 18 years or more
* All patients with laparoscopic salpingectomy for benign conditions (tubal ligation, during a hysterectomy), for prophylactic conditions (BRCA mutation) or in case of pelvic cancers
* Informed and signed consent

Exclusion Criteria:

* Interview revealing disorder entailing unacceptable risk of postoperative complications: coagulation disorder, immune system disorder, evolutive disease, etc.
* Pregnancy, ongoing or planned during the study period
* Allergy to fluorescein
* Previous allergy or anaphylactic shock during an angiography
* Allergic or hypersensibility reactions
* Severe asthma, chronic cardiac or pulmonary diseases
* Restricted renal function
* Patient under a beta-blockers treatment
* Inability to understand information provided
* Not covered by a national health insurance scheme, prisoner or under administrative supervision

Eligibility Criteria:
Inclusion Criteria:

* Woman aged 18 years or more
* All patients with laparoscopic salpingectomy for benign conditions (tubal ligation, during a hysterectomy), for prophylactic conditions (BRCA mutation) or in case of pelvic cancers
* Informed and signed consent

Exclusion Criteria:

* Interview revealing disorder entailing unacceptable risk of postoperative complications: coagulation disorder, immune system disorder, evolutive disease, etc.
* Pregnancy, ongoing or planned during the study period
* Allergy to fluorescein
* Previous allergy or anaphylactic shock during an angiography
* Allergic or hypersensibility reactions
* Severe asthma, chronic cardiac or pulmonary diseases
* Restricted renal function
* Patient under a beta-blockers treatment
* Inability to understand information provided
* Not covered by a national health insurance scheme, prisoner or under administrative supervision
Effect of Progressive Relaxation Exercıses on Dyspnea and Comfort Level in Individuals With COPD

The study is a randomised controlled experimental study conducted to examine the effect of progressive relaxation exercises on dyspnea and comfort level in individuals with chronic obstructive pulmonary disease. The study was conducted between January and August 2023 in the Internal Medicine Clinic of Izmir Urla State Hospital. Stratified and block randomisation method was used in the study and 42 patients, 21 intervention group and 21 control group, were completed. Patients in the intervention group received 30-minute progressive relaxation exercises for 6 weeks. Patients in the control group did not receive any intervention other than standard care practices. The data of the study were collected by face-to-face interview method using the Descriptive Information Form, Medical Research Council Dyspnea Scale, General Comfort Scale-Short Form and Patient Follow-up Form. Descriptive statistics, Shapiro Wilk test, Levene's test, Mauchly's W test, independent sample T test, Mann Whitney U test, dependent sample t test, Wilcoxon Signed Ranks test, Friedman test, Benferoni test and Fisher's Exact test were used to analyse the data obtained from the study. It was determined that the mean dyspnea level scores of the patients in the intervention group at week 6 were lower than the control group and this difference between the groups was statistically significant (p\<0.05). It was determined that the decrease in the mean comfort level scores of the patients in the intervention group according to the follow-up periods was statistically significant (p\<0.05). According to the results of the study, progressive relaxation exercises can be recommended as an effective nursing intervention to provide dyspnea management in patients with COPD.


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age and over
* Inpatient treatment in the Internal Medicine Clinic of Izmir Urla State Hospital
* Standardised Mini Mental Test score ≥24
* Dyspnea severity ≥2 according to the MMRC dyspnoea scale
* Diagnosed with Stage II and Stage III COPD according to GOLD criteria
* Functional competence to participate in progressive relaxation exercises
* Able to access and use a smartphone
* COPD patients who agreed to participate in the study.

Exclusion Criteria:

* Have any speech and hearing problems
* Lung disease other than COPD, physical dependence and psychiatric illness diagnosed with
* COPD patients in the acute exacerbation period.