cyrilzakka/clinical-trials huggingface dataset:
Clinical Follow-up After ACL Reconstruction

No former studies have done long-term evaluation on patients reconstructed with hamstrings graft, the use of Howells tibial guide and transtibial drilling of the femoral graft tunnel. The investigators aim to evaluate clinical, radiographic and subjective outcome at a minimum of 10 years after surgery. According to former published studies on alike methods, the use of transtibial drilling of the femoral graft tunnel causes an increased rotational instability of the knee. The investigators aim to map the clinical stability of this group as well as evaluating the general outcome at the long-time horizon.

Patients will be invited to a clinical follow-up with x-ray of the knee, scoring of Lysholm and IKDC subjective scores, clinical examination including instrumented testing with a KT-1000. After informed consent data will be collected from patient records and stored in a secured internal database. Analysis will be done with the SPSS package.

Eligibility Criteria:
Inclusion Criteria:

- Patients reconstructed with the given technique

Exclusion Criteria:

* Patients reconstructed with other techniques
* Concomitant ligamental surgery
* Bilateral ACL injury
* Revision surgery
RCT on the Efficacy of Methotrexate for the Prevention of GTD

A randomized, controlled trial to evaluate the efficacy of methotrexate for the prevention of postmolar gestational trophoblastic disease among patients with high-risk hydatidiform mole.

A randomized, controlled trial to evaluate the efficacy of methotrexate for the prevention of postmolar gestational trophoblastic disease among patients with high-risk hydatidiform mole.

Women who will undergo suction curettage for complete hydatidiform mole at the Philippine General Hospital, who are at risk for developing postmolar gestational trophoblastic disease will be included in the study. Patients will receive either a single course of methotrexate or vitamin B complex (Benutrex) within fourteen days from molar evacuation. Patients' serum beta HCG will be monitored 1 week after molar evacuation and then every 2 weeks until the titers become normal for three consecutive determinations, then monthly for 6 months (every 2 months for the next 6 months).

Eligibility Criteria:
Inclusion Criteria:

* diagnosis and molar evacuation done at the Department of Obstetrics and Gynecology of the Philippine General Hospital;
* patients who will undergo suction curettage for evacuation of molar pregnancy;
* histopathologically confirmed complete hydatidiform mole;
* must have at least one of the following risk factors for the development of postmolar gestational trophoblastic disease:

  * uterine size larger than age of gestation of more than 6 weeks
  * serum B-hCG titer more than or equal to 100,000 mlU/ml
  * theca lutein cysts more than or equal to 6 cms in size
  * gravidity of 4 or more
  * recurrent molar pregnancy
  * medical complications arising from trophoblastic proliferation such as DIC, pre-eclampsia, thyrotoxicosis, pulmonary insufficiency
* complete data;
* patient must have at least one year of regular follow-up and hCG monitoring following onset of remission;
* should have signed the consent form.

Exclusion Criteria:

* patients who are lost to follow-up or with incomplete data
* patients who underwent total hysterectomy for evacuation of molar pregnancy
* patients who are unable to complete the methotrexate treatment
* patients who get pregnant within a year following remission
* patients with a previous history of gestational trophoblastic neoplasia
* patients with medical problems/complications that inhibit administration of methotrexate
Visceral Osteopathic Manual Therapy Methods in Women With Stress Urinary Incontinence

The aim of this study is to evaluate the effect of visceral osteopathic manual therapy method for stress urinary incontinence in female patients. As a result of the study, the effect of visceral osteopathic manual therapy fascial release on bladder control, quality of life and flexibility will be evaluated.

Urinary incontinence (UI) is an important health problem that occurs when continence cannot be achieved and negatively affects the lives of individuals according to the International Continence Society (ICS). Stress urinary incontinence (SUI), one of the most common types of UI, is a problem that occurs during coughing, laughing, sneezing, exercise (one of which is caused by increased intra-abdominal pressure (Valsalva maneuver) and shows a steady increase in women with age. The aim in the treatment of SUI is to ensure that patients regain their continence skills. In recent years, conservative treatment methods have been preferred more in the treatment of SUI due to their ease of application and low cost. It is thought that Osteopathic Manual Therapy (OMT) reduces the negative effects of musculoskeletal pain and dysfunction on body systems, improves respiratory mechanics, venous and lymphatic drainage, and accordingly supports homeostasis and optimizes functions.

In this study, it is planned to investigate the effect of the visceral system and visceral fascia on SUI.

It is thought that the fascia surrounding the internal organs can be loosened and systematic diseases can be affected with the visceral osteopathic manual therapy (VOMT) method, which is among the osteopathic manual therapy methods.

Within the scope of the study, 40 volunteer female patients diagnosed with SUI will be evaluated and randomly divided into 2 groups. Day 1 evaluation scales will be applied to both groups, VOMT methods will be applied to the experimental group a total of four times a week, and bladder mobilization will be given as a home program, and no application will be made to the control group. Both groups will be re-evaluated in months 1 and 4. The inadequacy of studies conducted on this subject was an important factor in choosing this method.

Eligibility Criteria:
Inclusion Criteria:

* Being a woman between the ages of 18 and 70
* Being able to communicate in Turkish
* Being able to read and write
* Being able to understand and follow verbal prompts
* Being willing to participate in the study

Exclusion Criteria:

* Pregnancy
* Presence of prolapse
* Presence of vaginal and urinary system infection or malignancy
* Presence of neurological damage
* Having had any disease that may cause incontinence
* Having had surgery for SUI or urogynecological reasons in the last 2 months.
Quality of Life and Cardiometabolic Risk Factors in Patients After Debanding

Follow up of debanding patients

Follow up of debanding patients regarding cardiometabolic risk factors

Eligibility Criteria:
Inclusion criteria:

* Previous debanding after lap. gastric bypass

Exclusion criteria:

* Further bariatric procedures
Study of Sildenafil in Advanced Heart Failure.

Despite advances in medical therapy for patients with heart failure, one-third of patients remain limited by fatigue and shortness of breath.

Our previous study concluded that one dose of sildenafil (Viagra) lead to an improvement in heart pressure and exercise capacity.

Currently sildenafil is not FDA approved for the treatment of heart failure.

The purpose of this study is to determine if treatment with sildenafil for 12 weeks in patients with heart failure can improve exercise capacity and quality of life in people with heart failure.

This study will compare two groups of patients. One group will receive sildenafil and the other group will receive a placebo (a pill which looks like sildenafil, but contains no medication).

Patients will undergo a heart catheterization, echocardiogram and exercise stress test. Patients will then take study medication for 12 weeks. A repeat heart catheterization, echocardiogram and exercise stress test will then be performed.

Eligibility Criteria:
Inclusion Criteria:

Age \>18 years Ejection fraction \<40% Heart failure limited by fatigue and shortness of breath Pulmonary artery hypertension

Exclusion Criteria:

Patients taking the following medications: nitroglycerine pill/patch/paste, isordil, Imdur, antifungal agents and certain antidepressants.

Patients with a history of optic neuropathy or unexplained visual impairment. Patients with anemia.

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Pain Response Evaluation of a Combined Intervention to Cope Effectively

The purpose of this research is is to determine if the combination of non-opioid medication (duloxetine) and web-based pain-coping skills training (PCST) is beneficial for individuals with chronic musculoskeletal pain (CMP).

With this study, the study team hopes to address two important unanswered questions: (1) Does combination treatment consisting of duloxetine and web-based Cognitive Behavioral Therapy (CBT) optimize treatment outcomes? (2) Would adherence-focused guidance delivered by nurse clinician using motivational interviewing (MI) techniques enhance treatment effectiveness? This study is significant because the study team aims to optimize pain-related treatment outcomes at the primary care level where most patients with pain are managed. Importantly, the use of nurse clinician providing adherence-focused guidance (as opposed to content-focused guidance) on the continued practice (or use) of pain coping skills increases the likelihood that the study's intervention is scalable in the future. Effective, accessible and scalable psychoeducational treatments are needed to manage CMP in real world clinic settings.

Eligibility Criteria:
Inclusion Criteria:

* patients at the primary care clinic with daily pain for 3 months or longer affecting the low back, neck, hip, knee or widespread pain;
* at least moderate in BPI global pain severity

Exclusion Criteria:

* uncontrolled hypertension (because duloxetine rarely increases blood pressure)
* active suicidal ideation
* planned elective surgery during the study period (to avoid the confounding effect of possible complicated post-surgery recovery course on the primary outcome)
* ongoing unresolved disability claims
* inflammatory arthritis (e.g., lupus and ankylosing spondylitis)
* cancer-related musculoskeletal pain
* pregnancy
* history of bipolar disorder or schizophrenia
* narrow angle glaucoma
* severe renal impairment (creatinine clearance \<30)
* current use of duloxetine
* current use of any of the following medications (to avoid adverse drug-to-drug interactions): tricyclic antidepressant \> 25 mg daily dose, monoamine oxidase inhibitors, fluoxetine, sertraline, paroxetine, citalopram, escitalopram, venlafaxine, milnacipran, mirtazapine, gabapentin or aripiprazole, serotonin precursors (e.g., tryptophan), and strong CYP1A2 inhibitors (e.g., ciprofloxacin, other fluoroquinolones, fluvoxamine and verapamil)
Evaluation of Phenotypic and Genetic Properties in Male Subjects Affected by Hypohidrotic Ectodermal Dysplasia - A

The overall purpose of this study is to learn more about Hypohidrotic Ectodermal Dysplasia (HED) and to help in identifying treatment opportunities. Several evaluations will be conducted in this study: 1) the number of skin sweat glands you have and their ability to produce sweat; 2) your ability to grow hair; 3) the structure of your face compared to faces of people affected by HED; 4) molds of your teeth to see if and how they are different than people affected by HED.


Eligibility Criteria:
Inclusion Criteria:

1. Males age 14-29 years with clinical diagnosis of HED
2. No scalp shaving in the 6 months prior to enrollment
3. No current medical therapy for hair loss
4. Written informed consent for study and genotyping (or signed medical release of previous genetic test results)

Exclusion Criteria:

1. Medically significant condition as determined by the PI
2. Known hypersensitivity to pilocarpine or pilocarpine-like muscarinic agonists (e.g. Urecholine, Salagen, Pilocar, Provocholine)
3. Presence of cardiac pacemaker
A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women

This pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum HIV infected women on antiretrovirals (ART). The study will take place at several clinics in Lusaka, Zambia.

The standard of care for treating postpartum depression in the US is antidepressants, psychotherapy or both. Little data exist on the best method for treating perinatal depression (PND) in Sub-Saharan Africa. This is a mixed method study including a pilot randomized controlled trial (RCT) of antidepressant medication (ADM) versus interpersonal psychotherapy (IPT) and qualitative semi-structured interviews (SSIs). The study will enroll 100 pregnant HIV infected women over the age of 18 seeking postnatal care and continuing antiretroviral therapy in pregnancy. An additional 20 women enrolled in the RCT will be invited to participate in SSIs. Each participant will be followed for 24 weeks.

Eligibility Criteria:
Inclusion criteria:

* 18 years of age or older
* Documentation of confirmed HIV-1 infection
* Six to eight weeks postpartum
* Currently taking ART treatment
* Able and willing to provide written informed consent
* Willing to adhere to study visit schedule
* PND diagnosis confirmed by Mini-International Neuropsychiatric Interview

Exclusion criteria:

* Taking an ADM in the prior 12 months prior to enrollment
* Actively suicidal
* Known or suspected allergy or contraindication to first line Sertraline
* Any other condition (social or medical) which, in the opinion of the study staff, would make trial participation unsafe or complicate data interpretation.
Effects of Unilateral WBV on Muscleactivity of Contralateral Hip Adductor

The aim of this study is to investigate effects of femur exposed to unilateral vibration on the rest muscle electrical activity of contralateral hip adductors and contralateral soleus H-reflex in young adult men.

This study hypothesize that femur exposed to unilateral vibration may affect the rest muscle electrical activity of contralateral hip adductors. Vibration can effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. It has been showed that bone has an effect on the increase in muscle EMG activity caused by vibration in healthy young adults in a study. In this study, it was reported that vibrations-induced increases in muscle electrical activity of flexor carpi radialis (FCR) was related to ultradistal radius bone mineral content (BMC) and the FCR H-reflex was suppressed or depressed during vibration. This findings were reported to support the assumption that the bone exposed to cyclic mechanical loading may neuronally regulate muscle activity.

A total of 20 voluntaries are planned to include in this study.

Vibration will be applied the right lower extremity by whole-body vibration (PowerPlate Pro). Cases will stand on vibration plate. WBV will be applied at a frequency of 40 Hz and amplitude of 2 mm for 60 seconds. WBV will be applied one session only.

The rest muscle electrical activity of ipsilateral and contralateral hip adductor muscles at rest will be measured by PowerLab (data acquisition system, ADInstruments, Australia) device.The rest-EMGrms will be measured at before and during vibration. We also evaluate a change in contralateral soleus H reflex during vibration.

Effects of bone on the rest muscle electrical activity will be assessed by hip bone mineral density, bone mineral content and serum sclerostin level. The right hip bone mineral density (BMD) and BMC will be evaluated by bone densitometer (Norland). Plasma sclerostin level will be measured by using Human Sclerostin ELISA kıt before and after vibration.

Eligibility Criteria:
Inclusion Criteria:

* Age: 20-40 yrs
* Gender: Male
* Volunteer
* Healthy status: Patients having hypoesthesia in his leg and Healthy subjects
* Dominant hand:Right-handed

Exclusion Criteria:

* Bone diseases (osteoporosis, osteomalacia, paget's disease, neoplasm, etc),
* Systemic diseases (cardiovascular, endocrine, infections etc),
* Myopathy-tendinopathy
* Lower limb joint disease
* Vertigo
* Obesity (BMI \>30 kg/m2)
* Professional sportsman
* Male doing regular sports activities
* Skin disease in lower limb
* Non-cooperative subject
* Hemolysis of blood sample
Sonographic Characteristics of Tumor Indices in Patients With Cervical Cancer During Chemo-radiotherpy

Cervical tumors are characterized by vascular changes (in terms of quantity, volume and Flows) in the tumor. Due to a good access to the cervix through the vagina, these parameters can be assessed using a three dimensional supersonic. Sonographic characteristics of tumor indices measures before and after oncological treatments may shed light on the patient's prognosis.

no editional information. see above

Eligibility Criteria:
Inclusion Criteria:

* Cervical cancer patients intended to undergo chemotherapy or radiation, or both

Exclusion Criteria:

* no exclusions
Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome

AQUA FONTIS is a unicentric, multidisciplinary, prospective cross-section and longitudinal study that aims at the development of a more clear-cut diagnostic definition and classification of non-thyroidal illness syndrome (NTIS).

Detailed Description:

Non-thyroidal illness syndrome (NTIS), also referred to as euthyroid sick syndrome (ESS) or thyroid allostasis in critical illness, tumors, uremia and starvation (TACITUS), is a complex endocrine condition that may occur in critically ill patients. It is associated with significantly increased morbidity and mortality.

NTIS is characterised by three components that may occur single or in combination:

1. central hypothyroidism (transient thyrotropic insufficiency)
2. impaired protein binding of thyroid hormones and
3. reduced formation of T3 and increased conversion to rT3 (low-T3-syndrome).

Despite of long lasting research to some of its details NTIS is still poorly characterized in an integrative view. Additionally, it lacks a clinically usable classification.

Given the fact that patients with NTIS are faced with poor prognosis, several studies have been conducted in the past evaluating the question of possible treatment. However, they didn't yield unambiguous results, maybe due to the fact that these studies did not differentiate among the distinct components of NTIS.

Therefore, this study is intended to develop a clear-cut definition and classification of NTIS in order to set a foundation for future therapeutic studies.

This study recruits critically ill patients treated in medical and surgical intensive care units of the Bergmannsheil University hospitals for evaluation of integrative thyrotropic control and follow-up. From these data the correlation of individual prognosis with laboratory-defined components of NTIS will be determined.

This project is intended to:

1. deliver a prognostical aid by providing a differentiated classification,
2. to contribute to a standardised, rational and inexpensive diagnostical procedure and
3. to lay the foundation for future therapeutic trials by identifying subgroups that may benefit from therapy.

Eligibility Criteria:
Inclusion Criteria:

* Severe illness requiring intensive care
* Stay of at least 24 hours at the ICU

Exclusion Criteria:

* Substituted hypothyroidism or substitution in case of thyroid carcinoma
* Hyperthyroidism that is treated with thyrostatic agents and exhibits a THS level not below the reference region
* Manifest AIDS disease
Umbilical Cord Blood Therapy for Cerebral Palsy

This randomized controlled study aims to evaluate the efficacy of umbilical cord blood therapy for children with cerebral palsy.

Cerebral palsy is a disorder of movement and posture resulted from a non-progressive lesion or injury of the immature brain. It is a leading cause of childhood onset disability.

Many experimental animal studies have revealed that umbilical cord blood is useful to repair neurological injury in brain.

On the basis of many experimental studies, umbilical cord blood is suggested as a potential therapy for cerebral palsy.

Eligibility Criteria:
Inclusion Criteria:

* Cerebral Palsy with abnormal muscle tone
* Gross Motor Function Classification System (GMFCS): I, II, III, IV, V
* Willing to comply with all study procedure

Exclusion Criteria:

* Medical instability including pneumonia or renal function at enrollment
* Presence of known genetic disease
* Presence of drug hypersensitivity which is related to this study remedy
* Poor cooperation of guardian,including inactive attitude for rehabilitation and visits for follow-up
* Decision by the principal investigator when there are unexpected events including brain surgery, that may affect the outcome
Effectiveness of a Supervised Hospital-based Physical Exercise

To assess if physical activity is effective in reducing stress and anxiety in healthcare professionals.

To assess if physical activity is effective in reducing stress and anxiety in healthcare professionals.

To evaluate if physical activity is effective in improving the physical and mental state of health care professionals and improving several blood parameters (lipid profile and blood glucose).

Eligibility Criteria:
Inclusion criteria

* Apt for sports practice after review by the corresponding health professional of the Occupational Health Service,
* Motivation for sports practice (could be self-referred or on an EVA scale from a score for example of 6) being 0 not motivated at all and 10 totally motivated.

One could extrapolate the score limits of the EVA scale pain no motivation=0; mild motivation=1,2; moderate=3-5; high from 6.

* Professionals whose working day does not coincide with the hours during which the sessions are to be given.
* Professionals who do not work shifts.

Exclusion Criteria:

* Any type of contraindication for sports practice (Annex I),
* Staff who, due to their activity, have greater mobility in the hospital (orderlies).
* Osteoarticular injuries, cervical and lumbalgias.

Withdrawal criteria

-Within the intervention group - absence maximum two weeks to the exercises. This will not be taken into account during the summer period.