cyrilzakka/clinical-trials huggingface dataset:
Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure

Sacubitril-Valsartan reduced heart failure hospitalizations and cardiovascular mortality compared to enelapril in chronic heart failure. Furthermore, quality of life is improved. The decrease of NT-proBNP levels during Sacubitril-Valsartan treatment is associated with reverse left ventricular remodeling and improved left ventricular systolic function. However, the underlying mechanisms that contribute to these symptomatic and prognostic benefits are largely unknown. The aim of this study is to evaluate left ventricular hemodynamics in patients treated with Sacubitril-Valsartan using non-invasive pressure-volume analysis.


Eligibility Criteria:
Inclusion Criteria:

* Symptomatic heart failure (NYHA functional class II to IV)
* Reduced LV ejection fraction (≤ 40%)
* Clinical indication for therapy with Sacubitril-Valsartan

Exclusion Criteria:

* catecholamine therapy at inclusion
* existing therapy with Sacubitril-Valsartan
* planned cardiac resynchronization therapy (CRT) within 6 months; inclusion at least 3 months after CRT
* planned mitral or aortic valve procedure within 6 months; inclusion at least 3 months after valve procedure
* participation in another randomized heart failure trial
* severe aortic or mitral valve lesion
FREQUENCY OF VITAMIN D DEFICIENCY IN PREMATURE NEWBORN BORN BEFORE 32 WEEKS AND/OR WITH A BIRTH WEIGHT UNDER 1500g

Vitamin D plays an important role in phosphocalcic metabolism and bone homeostasis in newborns. Premature newborns are at risk of vitamin D deficiency and may require supplementation. In this context, the French Society of Pediatrics (Société Française de Pédiatrie) recommends systematic vitamin D testing at 1 month.

The aim of this study was to determine the frequency of vitamin D deficiency in premature newborns.


Eligibility Criteria:
Inclusion Criteria:

* Premature newborns born at a gestational age less than 32 weeks and/or birth weight less than 1500g
* Having received at least one dosage of 25 OH vitamin D.-

Exclusion Criteria:

* - Newborn whose parents or legal guardian refuse the use of their data for this research
Assessment of Ovarian Reserve in Female Cancer Survivors

Chemotherapy can damage the ovaries and cause premature menopause. In women treated before the age of 40 years, menopause does not usually occur. We have very little information about the impact of chemotherapy on ovarian function in this particular group of women. In this study, we will check hormone blood tests and ultrasound tests of the ovaries to measure the reserve of eggs left in the ovaries after treatment in young survivors of breast cancer and childhood cancer. We will do the same tests in our comparison group. We can use these results to estimate the reduction in fertility in young cancer survivors.

As women across North America and Europe increasingly delay childbirth, fertility preservation is emerging as an important issue among young breast cancer patients. The dramatic increase in survival for the major pediatric cancers in the last 50 years has resulted in an expanding population of childhood cancer survivors. The information currently available to counsel these patients about the impact of treatment on their fertility is inadequate. A significant degree of subfertility can exist prior to the onset of frank ovarian failure, and current studies do not address this.

This study will adopt new technologies that have revolutionized the evaluation of female fertility to assess ovarian function in young breast cancer survivors. The results will provide new, more accurate and clinically useful information to patients and physicians about the impact of cancer therapy on fertility. The results have the potential to influence clinical decisions regarding cancer treatment, and the use of assisted reproductive technologies for contemporary patients and survivors. Further, insofar as treatment advances are designed to improve disease control while reducing toxicity, these results may serve as the basis for better understanding the toxicity of modern therapy and provide opportunities for improvement.

Eligibility Criteria:
Inclusion Criteria:

* Breast Cancer Survivors

  1. histological confirmation of breast cancer
  2. received chemotherapy +/- radiotherapy with curative intent
  3. age 40 years or less at the time of diagnosis
  4. currently age 50 years or less
  5. currently disease free.
* Pediatric Cancer Survivors

  1. Received chemotherapy and / or radiotherapy with curative intent.
  2. Currently age 18 years and older.
  3. Currently premenopausal and attained at age 50 years or less.
  4. Currently disease free.
  5. Diagnosed with sarcoma or Hodgkin's disease or leukemia at 30 years or less.
* Control group 1. Premenopausal.

Exclusion Criteria:

* Breast Cancer Survivors

  1. treatment for malignancy other than breast cancer, involving chemotherapy or radiation to the ovaries/pelvis.
  2. any cancer recurrence
  3. hysterectomy/oophorectomy.
* Pediatric Cancer Survivors

  1. Hysterectomy / oophorectomy.
  2. Pelvic Radiation.
* Control group

  1. Received chemotherapy and / or pelvic radiation therapy,
  2. hysterectomy/oophorectomy.
To Evaluate the Safety of Duloxetine in Patients With Stress Urinary Incontinence

The patients are being followed in this study to determine the safety of taking the medication Duloxetine for a long period of time. The patients participating in this study suffer from Stress Urinary Incontinence.


Eligibility Criteria:
Inclusion Criteria:

Successfully completed the protocol for Study F1J-MC-SBAV.

-

Exclusion Criteria:

Treatment with a drug, not including study medication, that has not received regulatory approval at the time of study entry.

Use of excluded medications within 14 days prior to study entry or at any time during the study.

-
Compression and Cold Therapy on the Post-Operative Shoulder

The purpose of this study is to evaluate and compare clinical post-operative outcomes for patients using active cooling and compression device and those using ice bags and elastic wrap after acromioplasty or arthroscopic rotator cuff repair.


Eligibility Criteria:
Inclusion Criteria:

* Patient has undergone unilateral Rotator cuff repair or Acromioplasty
* Willing to sign a consent form
* Able to follow study procedures

Exclusion Criteria:

* Non-ambulatory
* Participation in concurrent investigational protocol
* Any bleeding coagulopathies
* Raynaud's disease or other vasospastic hypersensitivity or circulatory syndromes
* Hypertension (due to secondary vasoconstriction)
* Compromised local circulation (including localized compromise due to multiple surgical procedures)
* A history of vascular impairment (such as frostbite or arterial sclerosis)
* Cold allergy (cold urticaria) or prior adverse reactions to cold application
* Rheumatoid arthritis
* Local limb ischemia
* Paroxysmal cold hemoglobinuria
* Cryoglobulinemia or any disease that produces a marked cold pressor response
* Inflammatory phlebitis
* Acute inflammations of the veins (thrombophlebitis)
* Decompensated cardiac insufficiency
* Arterial dysregulation
* Erysipelas
* Deep acute venal thrombosis (phlebothrombosis)
* Carcinoma and carcinoma metastasis in the affected extremity
* Decompensated hypertonia
* Pulmonary embolisms
* Congestive heart failure
* Pulmonary edema
* Suspected deep vein thrombosis
* Acute inflammatory skin diseases
* Infection
* Venous or arterial occlusive disease
Effect of Different Kinesio Band Applications on Balance, Ankle Function and Jump

This research is a scientific research and is about "Effect of Different Kinesio Band Applications on Balance, ankle function and jump". Foot and ankle injuries are one of the most common problems among musculoskeletal injuries. Various methods are used to prevent and treat such injuries. In this study, it is aimed to evaluate the effectiveness of these applications by examining the effects of different kinesio band applications on balance, ankle function and jump. Personal information such as name, surname, height, weight will be obtained by asking the participant. The body mass index will be calculated by dividing the size of the size of the size of the length of the height. Different Kinesio band applications will be made to the participants and the effects of these applications will be evaluated. The equilibrium ability of the participants will be evaluated by Modified Star Excursion Balance Test). Foot and ankle functions In the evaluation, a questionnaire of 29 questions will be used. The jump performance will be determined by measuring the horizontal leap distances of the participants. In this study, the participants will be appointed to random groups. This randomness will be provided by using a system called Randomizer.org over the internet. Thus, each participant will be equal to the chances of being included in one of the 3 different band applications. This method allows the study to be conducted impartially and fairly. All evaluations and practices to be made within the scope of this research do not contain an invasive (surgery, needle, etc.) procedure and no risk or discomfort is foreseen for the participants. However, due to kinesio band applications, temporary effects may occur such as sensitivity or allergic reaction in the skin. If such a situation occurs, the tape will be removed immediately and necessary measures will be taken.


Eligibility Criteria:
Inclusion Criteria:

1- Healthy physiotherapy students between the ages of 18-25

Exclusion Criteria:

1. Hip, knee or foot pathology
2. Any neurological impairment
3. A history of lower limb fractures
Associating Renal Transplantation With the ITN Signature of Tolerance

This is an observational study for people who have received a kidney transplant within the past 1 to 5 years. Researchers in this study are looking for a certain pattern of genes and cells in the blood that has been found in a group of rare transplant patients who do not need immunosuppression. The study goal is to find out how common this pattern is in transplant patients, as a first step in determining if it can be used to personalize anti-rejection drug regimens better.

Following surgery, kidney transplant patients must take medications in order to prevent rejection of their transplanted organ. These medications can be very effective. Called immunosuppressive drugs, they work by reducing the activity of the immune system. Because of this, however, they can also have serious side effects, including increased risks of serious infections and certain types of cancer.

The ITN Registry of Tolerant Kidney Transplant Recipients recently identified a rare group of people whose immune system has accepted their transplant without continued use of immunosuppressive drugs. Researchers have found that these patients have a unique pattern of cells and genes expressed in their blood compared to other transplant patients.

The ARTIST study will ask the questions "Are there other transplant patients who show this pattern?" and "If so, how often?"

The goal is to find out if there are other transplant patients who are taking immunosuppression who also show this pattern of genes. If there are others, then this pattern may one day be useful in identifying transplant patients who could reduce the dose of immunosuppression they need without fear of rejection.

Researchers are seeking adults who have received a kidney transplant within the past 1 to 5 years. Participants will be asked to attend 3 short appointments with study doctors over a period of 2 years. At these visits, doctors will request demographic and clinical information, relevant medical histories and blood and urine samples. Participants will be compensated for their time.

It is important to note that this is an observational study only. Other than receiving consultations and advice from the transplant team, there is no direct medical benefit to participating. However, by participating, patients may play an active part in helping doctors learn to control kidney transplant rejection more effectively, with fewer drugs.

Eligibility Criteria:
Inclusion Criteria:

* Received first kidney transplant from a living or deceased donor.
* Kidney transplanted between 1 and 5 years ago.
* Calculated GFR of greater than or equal to 45 mL/min/1.73 m2 within last 6 months
* Ability to understand and provide informed consent.

Exclusion Criteria:

* History of steroid-resistant acute rejection
* History of two or more episodes of acute rejection
* Any acute rejection in the past year
* Current malignancy
* Transplant of another organ
* AIDS according to the CDC definition of AIDS.
Diet and Physical Activity Intervention for the Prevention of ADT-Induced Metabolic Changes in Patients With Prostate Cancer, TRIPLE-A PILOT Study

This clinical trial studies the effects of a diet and physical activity intervention on blood measures of lipids and insulin resistance in patients with prostate cancer undergoing radiation therapy (RT) and androgen deprivation therapy (ADT). ADT effectively slows the growth of prostate cancer cells, thereby enhancing the therapeutic effectiveness of RT. Despite the clinical gains, ADT leads to an array of side effects including insulin resistance, abnormal lipid levels, weight gain, increased visceral fat mass coupled with increased muscle wasting, and quality of life deterioration. A diet and physical activity intervention may intercept or prevent the abrupt metabolic and physiologic changes caused by androgen deprivation therapy in prostate cancer patients receiving ADT and RT.

OUTLINE:

Patients are randomized to 1 of 2 groups.

GROUP I (DIET AND PHYSICAL ACTIVITY): Patients attend 10 in-person or virtual sessions with a registered dietitian over 6 months to receive instructions on a modified DASH diet. Patients also attend 2 one-on-one sessions with an exercise psychologist to receive instruction to complete aerobic physical activity and strength/resistance training. Patients may also complete up to 21 additional supervised exercise sessions.

GROUP II (CONTROL): Patients attend a single in-person or virtual session with a registered dietitian to receive standard lifestyle recommendations based on the United States (US) dietary guidelines, activity goal of 30 minutes of physical activity 5 days/week; and discussion of the health benefits of weight maintenance.

Eligibility Criteria:
Inclusion Criteria:

* Age \>= 40 years
* Histologically confirmed adenocarcinoma of the prostate, (D'Amico risk category intermediate or high risk, localized or locoregional)
* Primary treatment is RT + ADT \[Zoladex, Lupron, Degarelix, and other luteinizing hormone-releasing hormone (luteinizing hormone releasing hormone \[LHRH\])-directed therapies\] with standard RT dose and fractionation (anti-androgen monotherapy will not be allowed
* Physically able to undertake an exercise program

Exclusion Criteria:

* Advanced, metastatic disease
* Planning to join a commercial/structured diet change or fitness program
* Have significant pre-existing T2D (poor glycemic control while on medication, defined as hemoglobin A1c of \>= 10 within the prior 12 months) or significant pre-existing cardiovascular disease (CVD) (myocardial infarction or stroke within prior six months)
* Physician confirmed cognitive impairment or alcohol/narcotic abuse
Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS

The diagnosis of bronchiolitis, the most frequent lung infectious disease in infancy, is based on clinical examination. Chest X-ray is proposed when a lung parenchymal condensation is suspected. Chest ultrasound is supposed to be a useful tool in the diagnosis of these complication but is poorly evaluated. We aim to compare chest X-ray and chest ultrasound for the diagnosis of parenchymal condensation in infant with bronchiolitis.

900 to 1000 children are admitted each year for bronchiolitis in the pediatric emergency department of the Toulouse Children Hospital. The diagnosis is based on clinical examination, but in some cases furthers examinations such as chest X-ray are necessary in order to look for a parenchymal condensation. Even if French recommendations do not place chest ultrasound in the care pathway to date, many recent studies show the usefulness, rapidity and reliability of ultrasound in parenchymal abnormalities. But regarding the bronchiolitis, few studies are available and including limited numbers of patients. In addition, the reduction of irradiation is a main goal, especially in children.

We propose to performed a chest ultrasound in infants (\<24 months) admitted for bronchiolitis with an available chest X-ray, in order to compare the performance of both examinations (X-ray and ultrasound) for the diagnosis of parenchymal condensation. Besides, to correlate initial chest ultrasound results and clinical evolution, parents will be contacted by phone 1 month after inclusion.

Primary outcome: The primary outcome is the sensitivity and specificity values of chest ultrasound for the diagnosis of parenchymal condensations diagnosed by chest X-ray. Positive and negative predictive values will also be estimated. This outcome is evaluated at the first visit (T0).

Secondary outcomes:

* To describe chest X-ray and ultrasound abnormalities in bronchiolitis.
* To evaluate the performance of chest ultrasound to distinguish retractile and non-retractile opacities complicating bronchiolitis.
* To study the correlation between clinical evolution at 1-month (malaise, place and duration of hospitalization, re-hospitalization, oxygen therapy, antibiotic therapy) and chest ultrasound results.

Follow-up parameters are recorded during a telephone call 1 month after inclusion.

Study design : It is a longitudinal, monocentric and prospective study with the aim to evaluate a diagnostic examination.

Eligibility Criteria:
Inclusion Criteria:

* Two years old patient at emergency Hospital (CHU-Toulouse) for bronchiolitis and performing of thoracic radiology
* Informed consent formed to sign by family before the exam and the evidence of social security regime affiliation.

Exclusion Criteria:

* Patient with cardiopulmonary disease or underlying immunosuppression
Desmopressin for Improving Nocturnal Enuresis in Patients After Radical Cystectomy With Bladder Reconstruction

The purpose of this study is to prospectively assess whether Desmopressin, given for a period of month to patients after radical cystectomy with orthotopic bladder reconstruction, improves and lowers the rate of nocturnal enuresis.

We will prospectively assess the utilization of Desmopressin in improving nocturnal enuresis in patients after radical cystectomy with orthotopic bladder reconstruction.

Patients after radical cystectomy with neobladder reconstruction will be given Desmopressin 0.1 mg once a day for a duration of one month.

Before beginning treatment patients will be given the NNES-Q questionnaire to assess severity of nocturnal enuresis.

At the end of treatment, the same questionnaire will be given to all patients to assess if nocturnal enuresis improved.

Sodium levels will be tested before treatment, 2 weeks after beginning treatment and at the end of treatment.

Eligibility Criteria:
Inclusion Criteria:

* Age above 18
* Able to give informed consent
* Patients afte radical cystectomy with orthotopic bladder reconstruction with night time incontinence

Exclusion Criteria:

* Patients with after radical cystectomy with orthotopic bladder reconstruction with daytime urinary incontinence
* Patients already treated with Desmopressin due to other reasons.
* Patients with an allergy or insensitivity to Desmopressin.
* Patients with known hyponatremia
* Patients with severe chronic renal failure and creatinine clearance of below 50 cc/sec.
* Patients with severe congestive heart failure
* Patients with active urinary tract infection
* Patients taking drug therapy which can interact with Desmopressin and affect it's action.Examples include Diuretics, Tricyclic antidepressants, Carbamezapine and Chlorpropamide AND Indomethacin.
* Patients with an indwelling urinary catheter.
Observational Study of the Clinico-biological Evolution and Standard of Care Offered to Patients With Ebola Virus Disease

This study highlighted the possibility, even in epidemic settings, of providing advanced supportive care for patients with VMEs. Indeed, while the prospect of offering any invasive medical care was widely discussed in 2014 in West Africa with the aim of limiting the exposure of caregivers, the epidemic of 2018-2019 has on the contrary seen the development of a number of medical care strategies, in parallel with the deployment of specific treatments. This study aims to describe a cohort of patients receiving this upgraded supportive care during the tenth epidemic in the DRC.


Eligibility Criteria:
Inclusion Criteria:

* Laboratory confirmed Ebola Virus Disease

Exclusion Criteria:

-
Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques

Postoperative cognitive decline (POCD) is a frequent complication after cardiac surgery. It is estimated that 40-70% of all cardiac patients show cognitive dysfunction during the first post-surgical week. Six weeks after surgery, this incidence decreases to 10-40% and the figure remains stable over the long-term.

The investigators will recruit 50 patients undergoing elective valve surgery and each patient will receive complete evaluation a) preoperative, one week before surgery; b) early postoperative, before hospital discharge; and c) late postoperative, 8 weeks follow up.

The investigators will apply Diffusion Tensor Imaging, 1Proton-Magnetic Resonance Spectroscopy and Morphometry studies with correlation to neuropsychological test battery to evaluate POCD.


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing elective valve surgery in Ospedale del Cuore, Fondazione G. Monasterio, Massa, Italy will prospectively enter the study.

Exclusion Criteria:

* History of head trauma, seizures, stroke, carotid artery stenosis (\>70%)
* History of any major surgery with general anesthesia
* Preoperative MMSE score less than 23 to exclude patients with dementia and mild cognitive impairment (MCI)
* Subjects who will be unable to complete the baseline neuropsychological battery due to cognitive impairment, psychiatric disease, substance abuse, blindness, or poor knowledge of Italian language
* Any major neurological complication after CABG surgery (stroke, seizures, encephalopathy not resolving within few postoperative days)
* if any contraindications to MRI safety, indicated in local MRI safety protocol
Health Belief Model Based Education on Human Papilloma Virus Infection and Vaccination

To evaluate impact of Health Belief Model Based Education on Human Papilloma Virus Infection and Vaccination among University Students

In this randomized controlled study, it aims to evaluate impact of Health Belief Model based virtual education on Human Papilloma Virus Infection and Vaccination among University Students.

Eligibility Criteria:
Inclusion Criteria:

* University students aged 18 years or over

Exclusion Criteria:

* University students have been received HPV vaccine