cyrilzakka/clinical-trials huggingface dataset:
Effects and Importance of Epinephrine/Adrenalin Deficiency in CAH

Individuals with CAH produce lower levels of epinephrine (adrenalin) than controls. This can be correlated to the CYP21A2 genotype and is most pronounced in the classic forms. Individuals with CAH have an increased risk of developing hypoglycemia because both cortisol and epinephrine are important counter regulatory hormones. Stress dosing is essential in situations of increased physical stress such as infections with fever for example.

Glucocorticoid treatment and stress dosing cannot compensate fully during physical stress neither for the reaction to psychological stress. This may render various types of difficulties in the individual's life.

We aim to investigate if the deficient epinephrine production can be confirmed and if it is related to the increased level of anxiety and vulnerability to stress that we observe in the patients.

Specific aims of the study:

* Analyse the epinephrine/adrenalin production in patients with CAH using measurements of epinephrine and metanephrine in blood, during an exercise test
* Assess stress vulnerability and anxiety using validated questionnaires
* Correlate the results to severity of disease, CYP21A2 genotype
* Investigate if psychological and somatic stress symptoms are related to the epinephrine production capacity.

After written informed consent study subjects, patients and controls, are invited to fill in a web based survey with the validated questionnaires. A link to the survey, expected to take 30 - 60 minutes to complete, is mailed to to the subjects . A subgroup of study subjects are invited to perform an ergo-spirometri test followed by the exercise test at the hospital. They are asked not to eat for 6 hours or drink any coffe during the day before the test. A venous catheter is used for blood sampling during the exercise. ECG, an orthostatic blood pressure test and a the ergo-spirometry test are performed before the subject is asked to do the exercise test, a cycling maximum test. Blood glucose, lactate, are followed every 4 minutes. Adrenal androgens, cortisol, insulin and methoxy-catecholamine are measured before and when the subject has reached maximum effort load and the test is ended.

The physical capacity, orthostatic blood pressure and the blood test results are related to the severity of CAH and to the maximum level of methoxy-cathecholamine produced by each individual. In the larger group of individuals, not taking part in the exercise test but completing the survey the genotype is correlated to the questionnaire results.

Eligibility Criteria:
Inclusion Criteria:

* CAH due to 21-hydroxylase deficiency,

Exclusion Criteria:

* Cardiovascular disease
Finances First: A Health Intervention in Low Income Single Mother Households

The purpose of this prospective, randomized, controlled three-year study is to compare the effect of a year-long financial education program versus usual care on health outcomes in single mother low income households.


Eligibility Criteria:
Inclusion Criteria:

* Unmarried
* Currently employed
* Annual salary must be less than 200% of the Federal Poverty Guideline
* Supporting at least one child at home
* Able to read and speak either English or Spanish

Exclusion Criteria:

* Currently abusing alcohol or recreational drugs
* Currently living in a domestic violence situation
* Pregnant or planning to become pregnant in the next year
Early Palliative Care for Patients With Haematological Malignancies

Patients suffering from haematological disease present symptoms of discomfort and currently benefit from palliative care skills only for the management of their end-of-life. However, in medical oncology, more and more studies tend to demonstrate the benefit on the quality of life of an early collaboration between the two specialties.

Investigator did the hypothesis that early integration of palliative care with conventional haematological care could decrease discomfort symptoms and add a real benefit on the patients' quality of life .

Patients suffering from haematological disease present symptoms of discomfort and currently benefit from palliative care skills only for the management of their end-of-life. However, in medical oncology, more and more studies tend to demonstrate the benefit on the quality of life of an early collaboration between the two specialties.

Investigator did the hypothesis that early integration of palliative care with conventional haematological care could decrease discomfort symptoms and add a real benefit on the patients' quality of life .

Eligibility Criteria:
Inclusion Criteria:

* Patients are over 70 years old
* Patients from being diagnosed with acute myeloid leukemia and high-risk myelodysplastic syndrome or after the third line of therapy for high-grade lymphoma.

Exclusion Criteria:

* All patients with a curative project (induction chemotherapy ou allogenic transplantation)
* All patients in a terminal palliative status
* Patients who don't speak French,
* Patients not able to read and write
* Patients who don't agree to participate in the protocol
* Patients with psychiatric troubles or cognitive disorders
* Patients under guardianship or curatorship, deprived of freedom or under justice protection.
Comparison of Closed-loop Operation After Morning Meal With and Without Carbohydrate Counting

Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosage based on the sensor's readings. A dual-hormone closed-loop system would regulate glucose levels through the infusion of two hormones: insulin and glucagon.

The main goal of this project is to assess whether a dual-hormone closed-loop strategy would alleviate the burden of carbohydrate counting from patients with type 1 diabetes (T1D) without a significant degradation in post-meal glucose control.

Each patient will be admitted twice to a clinical research facility. In one visit, patients will eat a morning meal accompanied with a matching insulin bolus (depending on the carbohydrate content of the meal) and glucose levels will be subsequently regulated using dual-hormone closed-loop system. In the other visit, patients will eat the same meal but will inject only a partial insulin bolus (not depending on carbohydrate content of the meal) and the remaining needed insulin will be delivered based on glucose sensor excursions as part of closed-loop operation. If post-meal glucose levels were indifferent between the two visits, then this would suggest that carbohydrate counting may not be necessary during closed-loop operation as the closed-loop system will give any remaining insulin needed to cover the glucose absorbed from the meal. Twelve subjects will be enrolled in this study.


Eligibility Criteria:
Inclusion Criteria:

* Males and females ≥ 18 and ≤ 65 years of old.
* Clinical diagnosis of type 1 diabetes for at least one year. The diagnosis of type 1 diabetes is based on the investigator's judgment and medical history (e.g. history of acido-ketosis, etc.); C peptide level and antibody determinations are not needed.
* The subject will have been on insulin pump therapy for at least 3 months.
* Last (less than 3 months) HbA1c ≤ 12%.

Exclusion Criteria:

* Clinically significant nephropathy, neuropathy (especially clinically significant gastroparesis) or retinopathy as judged by the investigator.
* Recent (\< 3 months) acute macrovascular event e.g. acute coronary syndrome or cardiac surgery.
* Pregnancy.
* Severe hypoglycemic episode within two weeks of screening.

  • Medication likely to affect with the interpretation of the results: Prandase, Victoza, Byetta and Symlin
* Known or suspected allergy to the trial products or meal contents.
* Other serious medical illness likely to interfere with study participation or with the ability to complete the trial by the judgment of the investigator.
* Failure to comply with team's recommendations (e.g. not willing to eat snack, not willing to change pump parameters, etc).
* Unreliable carbohydrate counting
* Problems with venous access
Induction Hypotension in Pediatric Population

This is a retrospective chart review to assess the incidence and the degree of blood pressure changes after induction of anesthesia and to study the effect of different induction agents on blood pressure.


Eligibility Criteria:
Inclusion Criteria:

* Patients between ages of 1 year to 8 years will be included in the study.
* Patients with ASA physical classification 1 and 2 will be studied.

Exclusion Criteria:

* Patients with any cardiovascular or kidney diseases will be excluded from the study.
Improving Real-world Function for Persons with Schizophrenia: a Single-case Experimental Design

Existing treatment for individuals with psychosis primarily targets positive symptoms but has only modest effects on cognition and negative symptoms. Cognitive strategy training shows promising effects in reducing negative symptoms and increasing activity initiation in individuals with schizophrenia.

This project aims to investigate the effect of the Perceive, Recall, Plan and Perform (PRPP) intervention in promoting effective use of cognitive strategies for adults with schizophrenia in performing their daily activities. Twenty-seven individuals with schizophrenia will be recruited from Sykehuset Innlandet (Innlandet Hospital Trust) and assessed using PRPP prior to an eight-session PRPP intervention. Re-assessment will be conducted after the intervention, as well as at 3 and 6 months, to evaluate the long-term effects of the intervention. A single-case design will be used to investigate the intervention's effects. The primary outcome measure will be the PRPP assessment, and the secondary outcome measure will be the Goal Attainment Scale (GAS). Generalization measures will be used to evaluate whether there are relevant changes beyond the primary and secondary goals.


Eligibility Criteria:
Inclusion Criteria:

* DSM-5 diagnosis of schizophrenia, understand and speak Norwegian, live in their own community context, but are patients in Sykehuset Innlandet ( Innlandet Hospital Trust), either as outpatients or on discharge from inpatient care, a subjective experience of functional impairment and/or cognitive difficulties identified in an initial interview, and a stable state without any major medication change for at least two months before inclusion

Exclusion Criteria:

* Major physical disability, a current substance abuse problem, and cognitive deficits of organic origin or mental retardation
Investigation of the Effects of Kinesio Taping and Manual Therapy in Patients With Bruxism

Bruxism is defined as a repetitive jaw-muscle activity characterized by tooth grinding or clenching accompanied with wearing of the teeth, and jaw muscle discomfort in the absence of a medical disorder . Bruxism has two distinct circadian manifestations: it can be nocturnal or diurnal. Hypertrophy of the masseter muscle is an objective sign of bruxism. Additionally, fatigue or stiffness in the masticatory muscles, pain in the temporomandibular joint or headaches are subjective signs of bruxism. According to literature, 85% to 90% of the general population experience episodes of bruxism during their lives. Thus, finding an effective treatment method for bruxism is crucial.The aim of this study is to investigate the effects of two different physiotherapy approaches on the masseter muscle thickness and stiffness in patients with Bruxism.

There is no certain treatment for Bruxism. However, the most recent recommendation is to follow the Multiple-P approach prior to medical drug regimens and invasive procedures. Different methods used in the conservative management of Bruxism are known as the "multiple-P" approach, which consists of; physiotherapy, plates, pep talk, pills and psychology . Physiotherapy generally focuses on two objectives: decreasing the adverse effects of bruxism to the masticatory muscles and increasing self-awareness regarding this habit. These studies involve different intervention such as massage of the masticatory and cervical muscles, electrotherapy, therapeutic exercises, taping interventions or relaxation therapies . However, literature regarding which physiotherapy intervention is the most effective in bruxism is not clear. Therefore patients in this study were randomly divided into one of two groups; manual therapy or kinesio taping. All patients were assessed at baseline, received 4 weeks of treatment and were assessed following the 4 weeks.

Eligibility Criteria:
Inclusion Criteria:

* A Bruxism Diagnosis according to the criteria of the international classification for sleep disorders
* Self-report of awake bruxism

Exclusion Criteria:

* Having more than 2 missing teeth
* The presence of removable partial dentures
* Having neurological, psychiatric or motor disorders
* Having any ongoing dental or physical therapy
* Active cancer
Effects of Respiratory Muscle Training in Obese Women

The objective of this study will be to evaluate the effects of inspiratory muscle training (IMT) on the physical fitness of obese women

It is believed that the application of these exercises helps in the improvement of inspiratory muscle performance, which should improve physical fitness and thus allow a better performance in the activities of daily living.

This is a clinical trial, in which adult obese volunteers aged 20-59 years will be evaluated, which will be randomized into two groups: training group (GT) and control group (CG). Both groups should meet the following inclusion criteria: Age between 20 and 59 years, BMI\> 35 and \<55 kg / m², with clinical stability, able to perform the physical tests and acceptance to participate in the study. Women with reports of decompensated heart disease, chronic obstructive pulmonary disease and asthma will be excluded; musculoskeletal and / or neuromuscular changes, which make it impossible to perform the tests. The evaluations will occur in two days with at least 48 hours of interval between them, within a period of seven days, before and after the respiratory muscle training of four weeks. In addition to anamnesis, the initial evaluation will include assessment of pulmonary function (SLF, forced vital capacity (FVC) and maximal voluntary ventilation (VVM)) by spirometry; respiratory muscle evaluation through the measures of Maximum Inspiratory Pressure (PIMax) and maximal sustained inspiratory pressure (PIMaxS); physical fitness assessment through the 6-minute step test (TD6), incremental shuttle walking test (ISWT) and Sentar e Levantar (SL) test, as well as assessment of dyspnea. For the TMI will be used equipment with pressure threshold pressure. During the 4-week period, the IMT will be performed 5 days a week and will consist of 2 series with 30 inspirations. Inspirations will be performed slowly and protracted. The training load will be 55% of the PIMáx readjusted weekly. Statistical analysis will be performed using BioEstat version 5.3. To evaluate the normality of distribution of the data will be used Shapiro-Wilk test. For the comparison of all variables studied, the Student's t-test or the Mann-Wittney test will be used. Pre- and post-training parametric results will also be compared statistically using variance analyzes of two variables (group × time) (ANOVA). Bonferroni tests will be used to examine differences between groups when indicated by ANOVA. The significance level of 5% will be adopted for all analyzes (P \<0.05) where the data will be expressed as mean and standard deviation.

Eligibility Criteria:
Inclusion Criteria:

* BMI\> 35 and \<55 kg / m²
* with clinical stability
* suitable for physical tests
* acceptance to participate in the study

Exclusion Criteria:

* women with reports of decompensated heart disease
* chronic obstructive pulmonary disease and asthma
* musculoskeletal and / or neuromuscular changes,
* which make it impossible to perform the tests.
Influence of Social Deprivation and Remoteness on Quality of Life in Adolescent's Surgical Scoliosis

The incidence of idiopathic scoliosis is 3% or approximatively 300,000 new cases per year in France. It is estimated that between 0.1 and 0.3% of patients will eventually require surgical management, between 500 and 1000 scoliosis are operated per year in France. To our knowledge, the impact of socio-economic and territorial inequalities on the quality of life before and after surgery of idiopathic scoliosis has not been studied previously.

Main objective:

-Assess the impact of socio-economic and territorial inequalities on the pre- and post-operative quality of life at 1 year after surgical idiopathic scoliosis management, in a French pediatric surgery multicenter cohort.

Secondary objective:

* Assess the impact of socio-economic and territorial inequalities on the quality of life pre and postoperative at 3 months after surgery on a French multicenter cohort.
* To assess the impact of severity and type of scoliosis on pre- and post-operative quality of life at 3 months and 1 year after surgery on a French multicenter cohort.


Eligibility Criteria:
Inclusion Criteria:

* Operated by posterior vertebral arthrodesis
* Opereted in pediatric surgery center
* Idiopathic scoliosis treated by surgery

Exclusion Criteria:

* Refusal to participate
* People unable to read or speak French (the questionnaire being in French)
* Non-idiopathic scoliosis
Qui Gong Programme vs Short Form Sun Style Tai Chi in COPD Patients

This was a Randomized control Trial. Purposive sampling was done to obtained Sample (n=78) which were randomly allocated to Group A (n=39) and Group B (n=39). Study was conducted from August 2019 to December 2019 in HBS Hospital Islamabad.To determine the effects of Qigong vs. Shot form Sun Style Tai Chi (SSTC) on Lung function, six min walk distance, dyspnea and quality of life in COPD patients.

Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and air-ﬂow limitation. Dyspnea is related with daily life activity. COPD patients often suffer from dyspnea and exacerbation, which leads to inactivity, deconditioning, and poor functional capacity and quality of life. Several interventions have been investigated with the aim of improving lung function, decreasing dyspnea symptoms and improving quality of life in this patient.

Tai Chi, an exercise involving both upper and lower extremities, originated from China. Tai chi is characterized by posture alignment, weight shifting and circular movements that incorporate elements of muscle endurance and strengthening, balance, relaxation and breathing control. Among previous studies Tai Chi in pulmonary rehabilitation showed a modest complementary benefit in exercise capacity.

The Tai Chi program is a safe, effective and feasible method to improve exercise capacity and health-related quality of life in people with COPD. Short form sun style Tai chi is one of the most common styles of t'ai chi. each form can be broken down into several movements which make it easy to learn and teach. Compared to some other styles of t'ai chi, SSTC involves less difficult movements, such as less deep-knee bending and single leg standing, which may make it more suitable for older people.

Qi Gong is defined as a mind-body exercise that involves whole body movements, breathing techniques, postural control, and internal awareness.

effects of Qi Gong on functional capacity and lung functions in COPD patients , and concluded that functional capacity, dyspnea scores and quality of life was significantly improved in mild to moderate COPD patients.

Eligibility Criteria:
Inclusion Criteria:

* Clinically Diagnosed patient: Mild to moderate stage COPD according to GOLD criteria {i-e Global Initiative for Chronic Obstructive Lung Disease (GOLD) }
* Patients who can walk without any dependency were included in study.

Exclusion Criteria:

* Patients with acute exacerbation within 4 weeks before starting the study
* Patient having significant, cognitive impairment
* Patient having Tuberculosis, asthma
* Patient having musculoskeletal
* Patient having psychological, cardiovascular and benign conditions (that prohibit exercise were excluded from the study)
Short and Long-arm Fiberglass Cast Immobilization for Distal Salter Harris I and II Forearm Fractures in Children

The aim of this study is to investigate whether short-arm fiberglass cast (SAC) immobilization provides fracture stabilization comparable to that of long-arm cast (LAC) treatment of displaced and non-displaced distal Salter Harris I/II forearm fractures in paediatric patients.

The patients are allocated randomly into the two groups(short-arm cast, long-arm cast). After confirming study participation, patients draw a sealed envelope enclosing a numbered card, which assignes them to one group or other. After choosing the envelope, neither the ED staff nor the parents and their childrenare blinded for the treatment groups. However, the data are going to be analyzed under blinded conditions

Eligibility Criteria:
Inclusion Criteria:

* Salter Harris I or II fracture of the distal radius or a forearm fracture
* informed consent

Exclusion Criteria:

* open/instable/intraarticular fracture
* age \<4 years or \> 16years
* no informed consent
The Performances of Spectral Domain Optical Coherence Tomography (OCT) for Distinguishing Glaucomatous Eyes

The purpose of this study is to evaluate performances of each parameters of spectral domain (Cirrus) optical coherence tomography for distinguishing between normal eyes, glaucoma suspect and glaucomatous eyes

Aim to determine which parameter of cirrus OCT is best sensitivity and specificity for glaucoma detection

Eligibility Criteria:
Inclusion Criteria:

* BCVA at least 20/60
* refractive error +/- 5 D Or astig +/- 3 D
* enrolled in 3 population group (glaucoma, glaucoma suspect or normal)

Exclusion Criteria:

* VA less than 20/60
* marked RF error
* previous ocular trauma or surgery
* unreliable visual field
* poor signal cirrus OCT (less than 7)
* other causes of optic nerve or macular disease other than glaucoma
A Retrospective Chart Review of Three Medifast Weight Control Centers

The primary aim of this study is to to retrospectively evaluate the efficacy of the MWCC Jump Start (Medifast's 5 \& 1) Plan on the following indices: weight loss, anthropometric changes, and reduction in common markers of coronary heart disease.

Portion-controlled meal replacements by themselves have been shown to be an effective weight control strategy in overweight and obese individuals. The addition of medical supervision has been shown to result in greater weight loss than meal replacements alone. MWCC provides this added support through individual weekly counseling sessions. Thus, the investigators plan to retrospectively evaluate the efficacy of the MWCC Jump Start (Medifast's 5 \& 1) Plan on the following indices: weight loss, anthropometric changes, and reduction in common markers of coronary heart disease.

Eligibility Criteria:
Inclusion Criteria:

* Adult males and females aged 18-70
* Followed the Jump Start (5 \& 1) Plan
* BMI ≥ 25
* Purchased a weight management program at the MWCC location in the last 3 years
* Signed patient health information consent form

Exclusion Criteria:

* On a plan other than the 5\&1 (Jump Start)
* Completed initial consultation but did not participate further
* Program stopped due to client not getting baseline labs
* Program stopped due for medical reasons unrelated to the 5 \& 1 (Jump Start) plan
* Currently an active participant at the MWCC
* No signed patient health information consent form or written request to revoke consent