cyrilzakka/clinical-trials huggingface dataset:
Adductor Canal Versus Femoral Nerve Block for Analgesia Post Total Knee Arthroscopy

Total knee arthroplasty or replacement (TKA) is a surgery performed for osteoarthritis of the knee which is increasingly performed as the population ages. It is a painful surgery and one of the methods to reduce post-operative pain is performing a regional anaesthesia technique. The current practice is to perform a femoral nerve block (FNB) which blocks the nerves supplying the knee joint and the thigh muscles (quadriceps). This provides effective analgesia. However, it also results in weakness of the quadriceps and may result in falls post-operatively.

Adductor canal block (ACB) is a new, alternative regional anaesthesia technique which is hypothesised to provide as effective analgesia, with less quadriceps weakness compared to FNB, hence potentially reducing the risk of falls post-operatively.

Investigators aim to study if the analgesia provided by ACB is as good as FNB while preserving quadriceps strength.


Eligibility Criteria:
Inclusion Criteria:

* ages 45-85
* American Society of Anaesthesiologists physical status 1-3
* BMI 18-35 kg/m2

Exclusion Criteria:

* inability to give consent, communicate, cooperate
* Patients with regular consumption of strong opioids (morphine, oxycodone) or steroids
* Patients with allergy to local anaesthetics or any drugs included in the study
* Patients with lower limb surgery in the preceding year
* Patients with pre-existing neurological deficits
* Patients who are unsuitable for general anaesthetics (eg difficult airway)
Supplementation Trial of KOKO Plus Among HIV Exposed Children in Accra

The overall aim of the research is to conduct a randomised controlled trial of KOKOPlus in young HIV exposed children attending HIV clinics in Accra, Ghana to test the effectiveness of KOKOPlus over a period of 6 months to improve nutritional status and child development in HIV exposed children 6-18 months of age in Accra

The specific objectives are to accomplish the following

1. To test the effectiveness of KOKOPlus to improve the nutritional status of HIV exposed infants aged 6-18 months.
2. To measure and compare nutritional status in intervention and control arms by monitoring growth in terms of height and weight over the period of 6 months
3. To measure and compare micronutrient status of intervention and control arms by comparing baseline midline and endline measurements of hemoglobin levels.
4. To measure and compare morbidity rates of intervention and control arms.
5. To measure and compare rates of achievement of child development goals between intervention and control arms using a standardized tool, the Caregiver Reported Early Development Instrument (CREDI).
6. To understand and record experiences relating to the use of KOKOPlus of mothers/caregivers in the intervention arm through focus group discussion

Eligibility Criteria:
Inclusion Criteria:

* Mother-infant dyads; HIV positive mothers and children between 6 and 12 months of age attending antiretroviral (ART) Clinics and child HIV Clinics.

Exclusion Criteria:

* Mothers who decline to participate in the study

Children with severe acute malnutrition (mid-upper arm circumference \<115 mm or a weight-for-height/length \<-3 Z-scores of the WHO growth standards).

Children on hospital admission

Children with diagnosed or apparent congenital conditions such as encephalitis, cleft palate, hole in heart, which negatively affect the child's ability to eat and/or growth.
Nexium RESPONSE Trial

The primary purpose of the study is to develop, and test, an algorithm for identification of responders to empirical esomeprazole treatment in general practices.


Eligibility Criteria:
Inclusion Criteria:

* Patients attending general practice due to symptoms suggestive of acid related disease and, according to normal routine, the GP would prescribe an acid-inhibiting agent

Exclusion Criteria:

* Alarm symptoms
* Pregnancy
* Contraindications to Nexium
Effect of Intrathecal vs Intraarticular Dexmedetomidine on Postoperative Pain Following Arthroscopy

Comparison between intrathecal Dexmedetomidine versus Intraarticular Dexmedetomidine on postoperative pain after knee arthroscopy.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients, ASA I-II, undergoing knee arthroscopy under spinal anesthesia.

Exclusion Criteria:

* Absolute or relative contraindications to spinal anesthesia, allergy to dexmedetomidine or chronic pain treatment.
The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Fusion The IVANOS-study

The average life expectancy in Denmark is increasing resulting in an increasing part of the population having age-related disease, ex lumbar spinal stenosis (LSS). LSS causes constriction of the nerves in the lumbar spine resulting in pain in the legs and lower back, especially when standing and walking, known as neurogenic claudicatio(Goh KJ FAU - Khalifa et al.). LSS occurs in a combination of degenerative changes in the lower back, including hypertrophy of the ligamentum flavum, arthrosis of the facet joints and bulging of the disc.

Current treatment of LSS is varied ranging from non-operative conservative treatment to operation.

Operative intervention shows very good results according to physical ability and pain(Christensen FB et al.;Hee HT and Wong;McGregor AH FAU - Hughes and Hughes;Xu et al.), but the most optimal treatment is still debated. Nevertheless, a decompression and, if needed, a spinal fusion is recommended.

The investigators want to se whether i-FACTOR improves clinical outcomes compared to using allograft in spinal fusion in the elderly, and thereby find an improved methods operating this difficult patient population.

The hypothesis is, that there is no difference in clinical outcomes whether you use i-FACTOR or allograft i non-instrumented spinal fusion surgery in patients with spinal stenosis due to degenerative listhesis.

Se above

Eligibility Criteria:
Inclusion Criteria:

1. Spinal stenosis, listhesis grade 1-2 (\>3 mm), facet joint arthrosis and flavum hypertrophia verified by a mr-scan and x-ray including maximally 2 levels ranging from L1-S1.
2. A score of 6 and more on Konno´s "History of Examination Characteristic".
3. Signed informed content.

Exclusion Criteria:

1. Any disease demanding obligate thromboprophylaxis treatment, including mechanical valve, (DVT with cancer/thrombophilia, AMI, apoplexia cerebri, TCI, valve-operation)\< 3 months, coronar metal stent \< 6 weeks and coronar drug eluted/coated stent \< 12 months.
2. Atrial fibrillation and one of the following: Mitral stenosis, valve prothesis and apoplexia cerebri/TCI.
3. Atrial fibrillation and two of the following: Heart insufficient, HT, DM, age \> 75 years, EF \< 35 %.
4. Known cancer in the axial skeleton.
5. Ongoing chemotherapy.
6. Fracture i the lower back within a year prior to inclusion.
7. Reduced distance of walking due to non-spinal related causes.
8. Candidate for more than two-level intervention.
9. Dementia assessed by the MMSE
10. ASA 3+4
11. Age below 60 years.
12. Missed 3 months of conservative treatment without success
13. The use of steroids and bisphosphonates.
14. Prior radiotherapy to the lower back.
15. Haematologic disease. -
Mode Specific Effects of Isokinetic Training of Hamstring on Hamstring to Quadriceps Ratio

Mode specificity of eccentric and concentric isokinetic training have been examined in previous studies but with conflicting results. The present study aimed to examine the mode-specific effects of eccentric and concentric isokinetic training of hamstring muscle at slow angular velocity on eccentric peak torque of hamstring (PTecc), concentric peak torque of quadriceps (PTcon), acceleration time of hamstring (AThams) and quadriceps (ATquad), deceleration time of hamstring (DThams) and quadriceps (DTquad), time to peak torque of hamstring (TPThams) and quadriceps (TPTquad), and functional Hamstring-to-Quadriceps ratio (PTecc/PTcon).

Several studies in past have tried to examine the mode specificity of concentric and eccentric training of different muscles and at different angular velocities i.e. whether concentric training will increase the concentric strength only or both concentric and eccentric strength and whether eccentric training will increase eccentric strength only or both eccentric and concentric strength.

Since conflicting reports are available regarding mode specificity of eccentric and concentric isokinetic training therefore one study was needed that can examine the mode specificity of these training in hamstring muscles at slow angular velocity. The present study aimed to examine the mode-specific effects of six weeks of isokinetic concentric and eccentric training of the hamstring muscle at slow angular velocity on the PTecc/PTcon, AT, DT, and TPT.

Eligibility Criteria:
Inclusion Criteria:

* Healthy young males
* Age between 18 to 27
* Recreationally active who used to engage regularly in 1-5 hours of physical activity per week

Exclusion Criteria:

* Individual presently indulged in strength training of knee.
* Individuals with any kind of injury around the knee, hip, ankle, foot
* Unconsolidated fractures around the knee. • Stress fractures
* Subjects with the acute phase of trauma, which may interfere with the exercise regime
* Subjects with cardio-respiratory problems and other medical problems like diabetes, asthma, etc.
* Subjects with tendinitis and other inflammatory conditions.
Prolonged Fasting With Meditation and Mild Physical Exercise

To determine the feasibility, safety and efficacy of fasting, participants are recruited in a 5-days fasting ( without any food, except unlimited mineral water),and do some fitness regimen (such as meditation and mild physical exercise ) during fasting.The samples will be collected from participates and subjected to comprehensive analysis ,including routine medical examination in blood, metabonomics and proteomics anlysis in serum and urine samples, gut microbiome analysis in stood samples, and so on.

1. Recruiting: 45 healthy people will be included in the clinical trial according to the Inclusion criteria and exclusion criteria.
2. Fasting : Participants fast for five days, without any food, except unlimited mineral water. Participants will do some fitness regimen (such as meditation and mild physical exercise ) during fasting.
3. Re-feeding: Gradually distribute participants with rice flour, porridge and juice in the next 3 days.
4. Follow-up :The health checklist is similar with that during fasting on the first month.
5. Data processing, statistics and analysis. Diet monitoring: The intake of glucose decreases, while the burning of fat increases, which can down-regulate glucose level in blood, up-regulate ketone level in urine. Thus, the fasting situation of participants can be monitored by the variation of blood glucose and urine ketone.

Eligibility Criteria:
Inclusion criteria

1. 18-65 years old, no nationality limitation, no gender limitation;
2. Male weight ≥ 50 kg, female weight ≥ 45 kg；BMI: 19-28 kg/m²;
3. The index of physical examination is in line with health standards;
4. People who have gone through a 7-day fasting before ;
5. Agree to take part in the trials and sign the informed consent form.

Exclusion criteria

1. People with unhealthy habits, such as smoking(5 cigarettes per day, or can not stop smoking in the trial), excessive drinking(drink regularly in the recent 6 months or more than 14 units of alcohol per week (1 unit = 360 ml beer or 45 ml alcohol with 40% spirits or 150 ml wine)) ;
2. People who processed fasting within one month;
3. Pregnancy, current breast-feeding or menstrual period;
4. People who are marantic, malnourished or anorectic;
5. People who have cardiovascular disease(coronary heart disease, atherosclerosis, arrhythmia, etc), serious metabolic and psychiatric disorders(hypertension, type 2 diabetes, hyperthyroidism, etc.);
6. People who have Mental illness, cancer, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), syphilis, human immunodeficiency virus (HIV) antibody positive.
7. people who has mental disorders according to the scales(Hamilton Anxiety Scale、Self-Rating Anxiety Scale、Self-rating depression scale)
Screening for Liver Cancer With CT vs. Ultrasound in Patients With Advanced Liver Disease

The purpose of this study is to determine whether ultrasound or CT scanning is more effective at detecting early liver cancer in patients with advanced liver disease.

Most cases of hepatocellular carcinoma (HCC) arise in patients with advanced liver disease, usually cirrhosis. Most patients with clinically evident HCC are not candidates for treatment with curative intent because of large tumor size, invasion of hepatic or portal veins, or metastatic disease. For this reason, screening for HCC at an asymptomatic and potentially curable stage in patients with advanced liver disease has been recommended by some authorities. Screening with various methods, of which ultrasound (US) and alpha-fetoprotein (AFP) have been the most extensively studied, has become accepted practice. Recently the technique of imaging the liver with or during both the hepatic arterial and portal venous phases of intravenous contrast ("liver-shuttle") has shown increased sensitivity in detecting HCCs compared to US.

The hypothesis of this study is that CT using a "liver-shuttle" protocol once a year is more sensitive and specific than US twice a year, both in combination with AFP for identification of potentially curable HCC in patients with cirrhosis. Patients will be randomized to "routine," accepted screening with hepatic US and AFP testing every 6 months or AFP testing every 6 months wtih triphasic CT every 12 months.

Eligibility Criteria:
Inclusion Criteria:

* liver biopsy or clinical diagnosis compatible with advanced liver fibrosis or cirrhosis
* potential candidate for treatment of HCC
* imaging study involving the liver in the last 12 months without evidence for HCC
* must be a veteran in VISN 23

Exclusion Criteria:

* active or untreated malignancy other than non-melanoma skin cancer
* patients with advanced medical conditions such as severe cardiovascular disease, COPD, or severe end-stage liver disease
* patients unable to receive intravenous contrast due to advanced kidney disease or severe allergy
* history of liver mass identified on imaging study
Developing Asthma Interventions Using Community Based Research

The purpose of this study is to identify community resources and challenges in improving the health of community members with asthma.

The primary goal of this project is to use Community-Based Participatory Research methodology to develop interventions aimed at improving asthma management in high-risk African American asthmatics. This "ground-up" longterm approach has never been tested before in asthmatics. The primary goal of this study will be accomplished with four specific aims:

Aim 1. Conduct focus groups to identify barriers to asthma management in the target population.

Aim 2. Use a community advisory board (CAB) consisting of participants selected from the various focus groups to gather information about solutions for the above barriers.

Aim 3. Use the information from the CAB to develop an intervention to improve asthma self management behaviors in the target population.

Aim 4. Refine the developed intervention based on feedback from focus groups conducted in Aim 1.

Volunteer will be asked to respond to several questions that address their perceptions about asthma. Volunteers will also be asked to discuss their beliefs about asthma. Everyone in the group will be given an opportunity to answer questions. Volunteers can decide that they no longer want to participate in the group discussion at any time.

The discussion will last from 1.5 - 2 hours. The focus group discussion will have a maximum of 10 people.

We will be audio and video taping the discussion so that we do not miss any information that volunteers share with us. The audio and video tapes will not be shared with anyone outside our staff.

Volunteer participation in this study is voluntary and there will be no negative consequences if volunteers decide not to participate. Volunteers are also free to withdraw from this study at any time. Withdrawal or refusal to participate will not affect health care services or other rights.

Eligibility Criteria:
Inclusion Criteria:

* Self-identified African-American, 18 yrs. or older, resident of Davidson County, Tennessee at least 1 year.

Exclusion Criteria:

* Under 18 yrs. of age
* Non-African American
* Non-English speaking
* Do not reside in Davidson County, Tennessee
The Reliability And Validity Of Family Satisfaction In Intensive Care Unit 24 (FS-ICU 24) Scale In Turkish Language

Purpose of this study was to investigate the validity and reliability of Family Satisfaction in the Intensive Care Unit-24 (FC-ICU 24) survey in Turkish language, evaluation the satisfaction of intensive care unit patients' relatives and to determine the factors affecting satisfaction.

Family Satisfaction in the Intensive Care Unit-24 (FC-ICU 24) survey is valid and reliable survey which was used to evaluate family satisfaction of intensive care units.

Turkish version which was prepared based on FS-ICU 24 survey was applied to the relatives of ICU patients (the ICUs in Anesthesiology, Internal Medicine, General Surgery and Neurosurgery ) in the Erciyes University Medical Faculty. The study was conducted between April and June 2015. The Turkish version was tested for reliability and validity, and it was proven to be reliable and valid. The subjects of the study were relatives of patients that were hospitalized for at least 48 hours, who had visited the patient at least once. Only one relative was included in the study per patient, and the survey was conducted after the required permissions were taken from the related medical departments.

Eligibility Criteria:
Inclusion Criteria:

* Family member of intensive care unit patient ( at least 48 hours hospitalization) aged at least 18

Exclusion Criteria:

* Rejection of family member
Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume

Traditional cardiac surgery requires patient connection to the Cardiopulmonary Bypass (CPB) apparatus which takes over the function of the heart and lungs while the surgeon performs the necessary surgery. The residual blood left in the CPB equipment (1.5-2.0 L) is centrifuged and washed leaving only red blood cells (RBCs) suspended in a saline solution. The RBCs are reinfused into the patient as needed by the anesthesiologist. The main problem with this technique is that many of the important components of the blood such as plasma proteins and clotting factors are discarded through cell washing. This study will explore a novel method (multiple-pass hemofiltration) of processing the residual pump blood which will allow the patient to receive their own whole blood with minimum waste of important components. The newer method of processing the residual pump volume has also been termed off-line modified ultrafiltration (off-line MUF) and is similar to the process that the kidneys use to filter the blood. It is hypothesized that multiple-pass hemofiltration of the residual CPB volume will reduce the occurrence of inflammatory responses, preserve plasma proteins, and decrease allogenic blood exposure and improve clinical outcomes as compared to centrifugation.

This study is being performed because the traditional method of recovery of the residual volume of blood from the cardiopulmonary bypass circuit involves centrifugation and washing of whole blood with a saline solution. This process is sufficient for the recovery of red blood cells however; it results in the discarding of other important components of the blood. The removal of white blood cells, plasma proteins and clotting factors may result in an increased risk of a adverse outcomes during the post-operative period. The new technique our team wants to investigate returns a greater proportion of the patients' whole blood for reinfusion. Our study objectives are to compare the two techniques and determine which technique produces the safest most reliable method of blood processing to help the patient have a smooth, short, transfusion free post-operative period in the intensive care unit (ICU).

Eligibility Criteria:
Inclusion Criteria:

* all males and females that will be receiving open heart surgery (Coronary Artery Bypass Grafts and / or Valve repair/replacement) during the study period.

Exclusion Criteria:

* history of bleeding disorders
* history inflammatory diseases rheumatoid arthritis
Reliability and Feasibility of WeeFIM Instrument to Measure Functional Independence in Pediatric Burns

PURPOSE:

Is to test the feasibility and the reliability of the Arabic version of wee functional independence measure (weeFIM) in children with healed burns.

BACKGROUND:

Since kids are the most influenced casualty of burn and they may have lasting disabilities because of this harm, consequently they should have care in evaluation and treatment procedure in exploration.

There are two main instruments that can be utilized to evaluate the function of young kid's which are the Functional independence measure for kids (WeeFIM) instrument and the Pediatric evaluation of disability inventory (PEDI) instrument.

Therefore, the aim of this study was to investigate the reliability and feasibility of the Arabic version of the WeeFIM instrument in kids from 3 years to 16 years of age with healed burn.

HYPOTHESES:

Arabic version of WeeFIM questionnaire will not be feasible and reliable to measure and report the functional outcome of kids with healed burns.

RESEARCH QUESTION:

Is the Arabic version of weeFIM instrument feasible and reliable enough to measure and report the functional outcome of children with healed burns?

1. First the weeFIM will undergo forward Arabic translation followed by English backward translation.
2. Second the instrument will be adapted to Egyptian accent.
3. Third the process of filling of questionnaire will be applied. It will be either parent filled or child filled. And will be performed by interview for illiterate patients.
4. Last, statistical analysis for feasibility and reliability will be performed.

Eligibility Criteria:
Inclusion Criteria:

* patients who had a healed burn with an age from 3 years to 16 years.
* All participants or their parents had to be able to read, write, and speak Arabic
* They had passed two weeks post-burn.

Exclusion Criteria:

* Children with a history of neurological impairment or orthopedic surgery to the limbs or spine.
* those with severe burns (4th degree burns), extensive burn is \>60%.
* infected burn wounds.
* other medical conditions that might impair physical performance.
* children with any medical illness present in the previous month.
Safety and Efficacy Registry of Yinyi Stent

Drug-eluting stents effectively reduce restenosis but may increase late thrombosis and delayed restenosis. Persistent polymer could be responsible. Local delivery of paclitxel from a polymer-free Yinyi stent (Dalian Yinyi biomaterial research and development co.ltd) may prevent these complications.


Eligibility Criteria:
Inclusion Criteria:

* age 18-80 years old
* both gender
* native coronary lesion
* narrowing \> 70%
* vessel size 2.5-4.0 in diameter

Exclusion Criteria:

* without informed consent,
* ST elevation myocardial infarction within 7 days,
* patient with ≤ 70% coronary narrowing at target lesion,
* left main lesion,
* multivessel narrowing need more than 3 stent implantations,
* by-pass graft,
* abnormal liver function before randomization,
* active hepatitis or muscular disease,
* impaired renal function with serum creatinine level \> 3mg/dl,
* impaired left ventricular function with LVEF \< 30%,
* Participate in other studies.