cyrilzakka/clinical-trials huggingface dataset:
Cardiovascular Risk Factors on Electrocardiographically and Hemodynamics Responses to Treadmill Exercise Test

The goal of this observational cross-sectional study is to analyze the effect of cardiovascular risk factors in healthy and asymptomatic populations. The main questions it aims to answer are:

* Does the combination of the presence of different risk factors increase the risk for abnormalities appearing on electrocardiograms, such as ischemia, arrhythmia, and hemodynamics effects during and at the peak of effort of treadmill exercise test?
* What are the main differences observed in the recovery period? Participants will answer an anamnesis of risk factors such as sex, race, age, familiar history of coronary artery disease, overweight or obesity, smoking, stress, and physical activity practice and perform treadmill exercise test on Ellestad protocol. If there a comparison groups: Researchers will compare individuals with most risk factors with those without, to see the cardiovascular responses.

The main outcomes broad the effect of simples and easy doccumented cardiovascular risk factors such as sex, race, age, familiar history of coronary artery disease, overweight or obesity, smoking, stress, and physical inactivity on electrocardiogram and hemodinamics abnormalities during and after exercise treadmill exercise test.

Eligibility Criteria:
Inclusion Criteria:

* Subjects that can complete the treadmill exercise test with the Ellestad protocol with 6 minutes of recovery.

Exclusion Criteria:

* Use of remedies for blood pressure, glycemia, cholesterol, and serum lipids;
* Symptomatically subjects;
* Electrocardiogram that are not able to be interpreted;
* Blood pressure in rest state ≥180 mmHg and ≥110 mmHg, for systolic and diastolic, respectively.
HCV Test and Treat Utilizing Simplified HCV Patient Education

The study hypothesis is that the test and treat model utilizing video-based patient education will have higher rates of hepatitis C virus (HCV) treatment initiation and treatment completion.

Viral hepatitis C (HCV) represents a major public health concern and is associated with significant morbidity and mortality. HCV screening and treatment among people who use drugs is challenging due to barriers leading to loss within HCV care cascades at most centers providing addiction care.

One critical element that would improve access to HCV therapy would be a test, educate and treat system, where people obtain drug on the same day as they are confirmed as Hepatitis C viremic.

Eligibility Criteria:
Inclusion Criteria:

* Men and women age greater or equal to18 at study entry or emancipated minors over greater or equal to 16 to less or equal 70 years at study entry
* HCV antibody positive
* HCV treatment naïve (no prior treatment with an approved or investigational anti HCV medication)

Exclusion Criteria:

* Current or history of decompensated liver disease (including but not limited to encephalopathy, variceal bleeding, or ascites) prior to study entry
* History of hepatocellular carcinoma (HCC)
* Any history of active Hepatitis B or positive HBsAg positive test
* HCV RNA undetectable
Role of the Inflammatory Receptors in the Pathogenesis of Atherosclerosis

The primary objective of this study is to assess whether inflammatory receptors play a role in the pathogenesis of atherosclerosis.

Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition and macrophages/foam cell accumulation beneath the arterial intima. Immune competent cells are abundant in atherosclerotic lesions, where they produce mainly proinflammatory cytokines. Macrophages play a central role in each stage of the pathogenesis of atherosclerosis. At the beginning, the so-called foam cells contribute to the formation of early lesions; in mature plaques, macrophages constitute 50% of the cells in the lesion; finally, they are involved in the mechanisms leading to plaque rupture.

The primary objective of this study is to assess whether the inflammatory receptors play a role in the pathogenesis of atherosclerosis.

Eligibility Criteria:
Study Population 1 Patients with ST-elevation myocardial infarction (STEMI) with angiographic evidence of massive thrombosis in the culprit artery undergoing primary percutaneous coronary intervention (PCI)

Criteria

Inclusion Criteria:

* ST-elevation myocardial infarction
* Angiographic evidence of massive thrombosis in the culprit artery
* Indication to primary percutaneous coronary intervention (PCI)
* Able to understand and willing to sign the informed CF

Exclusion Criteria:

• Women of child bearing potential patients must demonstrate a negative pregnancy test performed within 24 hours before CT

Study Population 2 Patients with coronary artery disease in stable conditions scheduled to undergo elective percutaneous coronary intervention and patients with

Criteria

Inclusion Criteria:

* A de novo native coronary artery lesions (reference vessel diameter:2.5-3.75 mm)
* Class I indication to elective percutaneous coronary intervention
* Stable conditions and no recent acute coronary syndromes
* Normal baseline values of markers of myocardial damage (creatine kinase, creatine kinase-MB, myoglobin, and troponin I)
* Able to understand and willing to sign the informed CF

Exclusion Criteria:

• Women of child bearing potential patients must demonstrate a negative pregnancy test performed within 24 hours before CT
Intravenous Vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients

The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery.

The results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinical and patient-centered outcomes after hip fracture surgery. It will randomize 42 older adults to receive either oral or IV acetaminophen after hip fracture surgery.


Eligibility Criteria:
Inclusion Criteria:

* 60 years of age and older
* Patients who were ambulating without human assistance before fracture, with any type of non-neoplastic hip fracture
* Patients undergoing surgical treatment as an inpatient

Exclusion Criteria:

* Patients with neoplastic hip fracture
* Severe cognitive impairment (Montreal Cognitive Assessment (MoCA) \<10)
* Pre-existing delirium
* Known hypersensitivity or allergy to acetaminophen
* Severe or chronic liver or kidney dysfunction
* Planned postoperative ventilation
* Swallowing issues and/or dysphagia
* English language limitation
* Weight \<50kg
Considering Racial and Acculturation Stress in Addressing Trauma

Investigators plan to offer two evidence based interventions - Trauma Focused Cognitive Behavioral Therapy (CBT) (TF-CBT) and Trauma Systems therapy (TST) to traumatized children and their families. The investigators are looking to evaluate the effectiveness of these interventions in the context of additional stress related to racialized trauma and acculturation stress


Eligibility Criteria:
Inclusion Criteria:

* Child/adolescent aged 5-17 years of age who has experienced trauma with associated and related emotional dysregulation (i.e PTSD) and one of their parent/guardian
* Have capacity and willingness to provide consent or age-appropriate assent

Exclusion Criteria:

* Individual with intellectual disability with an IQ\<70
* Individual with active suicidality, homicidality, or other symptoms at the time of enrollment that warrants hospitalization
Visual Acuity and Optical Coherence Tomography One Year After ILM-flap Transposition

ILM-flap (internal limiting Membrane-flap) transposition is a new surgical option in repair of macular holes, therefore one year outcomes are needed to better evaluate that method.

Patients that have been scheduled for vitrectomy with ILM-flap transposition, a new surgical option in repair of macular holes, are invited to a follow-up one year after surgery, including optical coherence tomography and visual acuity testing.

Eligibility Criteria:
Inclusion Criteria:

* history of ILM-flap transposition

Exclusion Criteria:

* none
Expanded Access to ABT-414

This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to ABT-414 prior to approval by the local regulatory agency. Availability will depend on territory eligibility. Participating sites will be added as they apply for and are approved for the EAP. A medical doctor must decide whether the potential benefit outweighs the risk of receiving an investigational therapy based on the individual patient's medical history and program eligibility criteria.


Eligibility Criteria:
Inclusion Criteria:

* Participant must have epidermal growth factor receptor (EGFR) amplification or EGFRvIII mutation.
* Health Care Provider (HCP) must have prior clinical trial experience with ABT-414.
* The participant must not be eligible for an ABT-414 clinical trial.
* Pediatric participants may be evaluated on a case by case basis.
Pilot Study Of Primary And Secondary Attention-Deficit/Hyperactivity Disorder Among Survivors Of Childhood Cancer

This is a pilot study that will be an exploratory investigation of the rate of occurrence of ADHD/S-ADHD in adolescent cancer survivors. The procedures that will be used for identifying attention problem symptoms, determining the frequency and severity of such symptoms, and characterizing the level of impairment resulting from the symptoms are novel to pediatric oncology research.This pilot study will draw from the approach used in traumatic brain injury research of post-injury effects to illuminate more clearly the nature of attentional late effects experienced by survivors of childhood cancer.

1. This study will investigate the feasibility of assessing symptoms of developmental ADHD and "secondary ADHD" (S-ADHD) among adolescent survivors of childhood cancer using a structured diagnostic clinical interview procedure. (S-ADHD describes an acquired clinical presentation that is consistent with the diagnostic criteria of ADHD).
2. This study will provide preliminary estimates of the rate of occurrence of ADHD/S-ADHD among adolescent survivors of childhood cancer as compared to the prevalence of developmental ADHD in the general population.
3. The study will examine the relationship between ADHD/S-ADHD symptoms and laboratory measures traditionally used to assess specific components of attention (e.g., CPT) in survivors of childhood cancer.
4. The study will examine the relationship between ADHD/S-ADHD symptoms and smoking (including intentions, behaviors, and motivators) among adolescent survivors of childhood cancer.

Eligibility Criteria:
Inclusion Criteria:

1. Patients treated for acute lymphoblastic leukemia (ALL) OR primary central nervous system (CNS) tumor.
2. Completed primary treatment at least one year prior to enrollment with no evidence of active disease.
3. Age 12-17 years inclusive at the time of enrollment.
4. At least one parent/guardian must be present.
5. Participant and parent are able to understand English.
6. Participant and parent are willing and able to provide consent/assent according to institutional guidelines.
7. Parent/guardian signs consent.

Exclusion Criteria:

1.Significant impairment in intellectual functioning (e.g., full or estimated IQ \<70) as documented in the medical record.
Validity and Reliability of Turkish Version of Marx Activity Rating Scale

The aim of the study is to investigate Turkish validity and reliability of Marx Activity Rating Scale for patients with knee disorders.

The aim of the study is to investigate Turkish validity and reliability of Marx Activity Rating Scale for patients with knee disorders.The study will include 30 patients with different types of knee disorders such as traumatic meniscal and ligament injuries,fractures,osteoarthtiris and patellofemoral joint pain.This study will conduct at Palmer\&Still Physiotherapy Clinic.The original English form will be translated into Turkish according to guidelines.Subjects will complete translated Marx Activity Rating Scale,International Knee Documentation Committee (IKDC) subjective knee form and EuroQol EQ5D.Re-testing will be obtained after 1 month.

Eligibility Criteria:
Inclusion Criteria:

Older than 18 years can read and write Turkish have knee disorders such as traumatic mensical and ligament injuries,fractures,patellofemoral pain syndrome and/or mild osteoarthritis

Exclusion Criteria:

Individuals with multiple ligament injuries, large osteochondral fractures, large focal cartilage defects requiring surgery, malignancy, and advanced osteoarthritis.
High-flow Conditioned Oxygen Therapy Versus Non-invasive Ventilation: Prevention of Post-extubation Failure

The main aim is to demonstrate whether the high flow conditioned oxygen therapy reduces the reintubation rate. Post-extubation respiratory failure risk will be stratified (as the randomization). In high risk patients high flow conditioned oxygen therapy will be compared with with not conditioned non-invasive mechanical ventilation. In low risk patients comparison will be conventional oxygen therapy. Hypercapnic patients will be excluded.


Eligibility Criteria:
Inclusion Criteria:

* Low Risk Patients:
* Any extubated patients after tolerating a spontaneous breathing trial.
* High Risk Patients:
* Any extubated patients after \>48 hours under mechanical ventilation and any of the following:
* \>65 years

  * cardiac failure as the primary indication of mechanical ventilation
  * COPD
  * APACHE II \>12 points the extubation day
  * BMI \>30
  * inability to manage respiratory secretions

    * 1 failed spontaneous breathing trial
    * 1 comorbidity
    * 7 days under mechanical ventilation

Exclusion Criteria:

* \<18 years
* thacheotomized patients
* recent facial or cervical trauma/surgery
* active gastro-intestinal bleeding
* lack of cooperation and patients with any failed spontaneous breathing trial because of hypercapnia development.
Mobility and Voiding Exercises in Older Women with Urinary Incontinence (MoVEonUp)

A prospective, two-arm randomized clinical trial utilizing a multidimensional intervention to reduce falls in older women with Urinary Urge Incontinence. The intervention consist of general balance and strength training, bladder training and urge suppression, and home hazard assessments. The control group will receive informational booklets on fall prevention and behavioral treatment for urinary urge incontinence.


Eligibility Criteria:
Inclusion Criteria:

* Female
* 70 or older
* Living independently in the community
* Willingness to be randomized.
* Ability to read and understand English
* Be able to provide informed consent
* Low physical activity (physically active for 30 minutes or more less than or equal to 2 days per week on average over the past 6 months) per PAS
* Ambulatory (defined as patient not confined to bed or wheelchair OR ability to walk with or without an assistive device)
* Self-reported moderate to severe urge-predominant UI based on the ICIQ-SF \> 6 (Q 1+2+3)
* Not planning to initiate new UI or overactive bladder (OAB) treatment during the study duration
* Capable of participation in an exercise program without exacerbating any pre-existing condition(s), as determined by the study PI or designee

Exclusion Criteria:

* Pelvic organ prolapse passed the hymen (per patient report)
* Undergoing active treatment for cancer (other than non-melanoma skin cancer)
* Uncorrected visual or hearing loss.
* Other urinary conditions or procedures that may affect continence status for example: urethral diverticulum, previous augmentation cystoplasty
* Progressive neurodegenerative disease e.g. Parkinson's disease, multiple sclerosis per patient report
* History of stroke or carotid sensitivity (i.e. syncopal falls) per patient report
* Unstable cardiac disease per patient report
* Fracture or joint replacement within the last six months per patient report
* Significant cognitive impairment (defined as a modified TICs score of \< 27)
* Per PI discretion, participant cannot enroll in study
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure

The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation. Our study aims at comparing stepwise withdrawal of Non-invasive ventilation versus immediate withdrawal of Non-invasive ventilation. The primary endpoint is to compare the rate of success between two withdrawal methods. The investigators define success as no recurrence of acute hypercapnic respiratory failure or restitution of Non-invasive ventilation within 48 hours after NIV is stopped. The secondary endpoints include time to recurrence of acute hypercapnic respiratory failure measured from the time of randomisation, the total days of Non-invasive ventilation use and the days of hospitalisation. Results from this trial will inform design of future randomised trial in this area.

All patients would receive standard medical treatment with inhaled bronchodilator, systemic steroid, antibiotics according to our local bacteriology. Acute NIV was initiated by trained respiratory nurses according to standardised protocols. The nurses would be at the bedside during the initial acclimatization. BIPAP vision was used to provide bi-level pressure support ventilation. Interfacing with different types of nasal or full-mask would be individualised. NIV was used for as many as possible in the first day, at least 20 hrs. Throughout the NIV treatment, the following parameters will be monitored when NIV is started: arterial blood gases, respiratory rate, heart rate and blood pressure, mental state, pulse oximetry. If a patient failed to respond to NIV, he or she would be intubated if appropriate. Criteria for failure include lack of clinical improvement with increasing dyspnea and deterioration of blood gases, hemodynamic instability, uncontrolled ventricular arrythmia, development of hypercapnic coma and cardiopulmonary arrest.

A patient would be considered suitable to withdraw from the ventilator if he or she fulfil the criteria at rest.

Eligibility Criteria:
Inclusion Criteria:

* COPD patients with AHRF requiring NIV
* the patient is cooperative with NIV treatment
* the patient is willing to give their written informed consent to participate in the study
* patient is stabilised after acute treatment after NIV as evidenced by ALL of the below::

  * normalisation of arterial pH
  * clinical stability as evidenced by
  * SpO2 \> 88% on 2LO2 or less
  * respiratory rate \< 25
  * heart rate \< 120 bpm
  * systolic blood pressure \> 90 mmHg
  * patient not in agitation, diaphoresis or anxiety

Exclusion Criteria:

* patients with non-COPD causes of AHRF, for example, chest infection and heart failure
* patients who are currently on home NIV
* patients who have contraindications to NIV and those who refused or failed NIV during an initial 15 minutes acclimatization period
* other significant co-morbid conditions that in the investigators' view , would confer an adverse prognosis during the study period
Investigation the Effect of Rectus Abdominis and Erector Spinae Muscle Fatigue on the Viscoelastic Properties of Thoracolumbal Fascia

The rectus abdominis, which enables the trunk to flex with its activation, and the erector spinae muscles, which provide trunk extension with its activation, are among the structures located in the core region and involved in the stabilization of the spine. While the muscles in the core area actively provide the stabilization of the medulla spinalis, this stabilization is also supported by passive subsystems. Passive subsystem fascia etc. creates structures. Thoracolumbar fascia is one of the important fascias due to its connections with the muscles in the core area. Fatigue etc. of the structures in the core area. As a result of physiological processes, their functionality may decrease, which may affect the stabilization of the core area. Fatigue occurs as a result of lactic acid accumulation in the structures in the body and this process is called the recovery period. The types of exercises performed also affect the recovery period. For this reason, different exercise types such as dynamic and static can be used when creating exercise programs. Due to the functions of the rectus abdominis and erector spinae muscles and thoracolumbar fascia in the body, their effects on the spine and their connections with each other; It is aimed to examine the effect of muscle fatigue in these muscles on the viscoelastic properties of the thoracolumbar fascia and their recovery rates.


Eligibility Criteria:
Inclusion Criteria:

* Being a healthy individual between the ages of 18-35
* Not having any chronic disease
* Body mass index (BMI) is 24.9 kg/m2 or lower
* Volunteering to participate in the study

Exclusion Criteria:

* Having a chronic illness (Diabetes, blood pressure, etc.)
* Having a diagnosed spine problem
* Being diagnosed with scoliosis
* Pilates, yoga, etc. in the last 6 months. to have done sports
* Beighton score of 4 or above
* Being diagnosed with cardiopulmonary system disease
Chest Tube Drainage of Transudative Pleural Effusions Hastens Liberation From Mechanical Ventilation

The purpose of this study is to determine whether chest tubes to drain transudative pleural effusions helps patients come off mechanical ventilation earlier.


Eligibility Criteria:
Inclusion Criteria:

* Patients with transudative pleural effusion and requiring mechanical ventilation

Exclusion Criteria:

* Patients with coagulopathy