cyrilzakka/clinical-trials huggingface dataset:
Fear of Activity in Situations (FActS) - Study 2016

The aim of the study is to evaluate the psychometric properties of the newly developed Fear of Activity in Situations - Heart Failure (FActS-HF 15) scale. The FActS-HF 15 is a questionnaire assessing fear of physical activity (fear of movement) in patients with chronic heart failure. FActS-HF 15 assesses cognitions and emotions that can occur during physical activity, independent of avoidance behavior. Firstly, the study aims at evaluating the instrument's reliability and validity and to investigate associations of fear of physical activity with demographic, medical, and psychosocial patient characteristics. Secondly, the study aims at assessing everyday physical activity using accelerometric measures to test the hypothesis that fear of physical activity in patients with heart failure is related with lower actual physical activity.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of heart failure stage B or C (Hunt et al., 2005), or: New York Heart Failure classification II to IIIb:

  1. Systolic dysfunction: left ventricular ejection fraction \< 45% in the last 6 month
  2. Diastolic dysfunction: left ventricular ejection fraction \>= 45% in the last 6 month

Exclusion Criteria:

* complex ventricular arrhythmias
* acute myocarditis
* symptomatic cardiac valve stenosis
* instable angina pectoris
* other severe diseases, that impair physical activity (e.g., advanced stages of cancer)
* insufficient language skills in German to answer the questionnaires
* insufficient cognitive skills to answer the questionnaires
Swiss Multiple Sclerosis Registry

The Swiss Multiple Sclerosis Registry is a national, patient-centered registry with the aim to document the epidemiology of multiple sclerosis (MS), as well as the quality of life of persons living with MS in Switzerland.

The Swiss Multiple Sclerosis Registry is a national, patient-centered research project with the aim to document the epidemiology of multiple sclerosis (MS), as well as the quality of life of persons living with MS in Switzerland. The Swiss MS Registry pursues a "Citizen Science" approach, that is, persons with MS are not just study participants but also act as MS experts and are active contributors to the interdisciplinary Swiss MS Registry research network. Initiated and funded by the Swiss MS Society, the Swiss MS Registry represents a collaborative effort by numerous MS caregivers, researchers and persons with MS. It is hosted by the Epidemiology, Biostatistics and Prevention Institute at the University of Zurich.

How many MS-affected persons are living in Switzerland and how are they coping with MS in their daily lives? What is the current situation with regard to access to and use of drug and non-drug treatments for MS? These and other questions are addressed by means of semi-annual surveys. Further research activities concern the quality of life of persons with MS, mobility, personal resources and support by friends and family, work situation, mental health, clinical progression of MS, as well as alternative therapies.

Owing to a flexible study design, participants can decide between different levels of commitment (from one-time surveys to repeated, semiannual surveys and medical records review). Furthermore, study participants receive summaries of their data as charts and tables. Data collection primarily occurs via a newly designed online platform, but paper-and-pencil questionnaires are also available. As an additional incentive, the online platform includes a diary with basic capabilities for analyses and printing.

Eligibility Criteria:
Inclusion Criteria:

* Persons with a confirmed Multiple Sclerosis Diagnosis
* 18 years and older
* Living in Switzerland or receiving MS care in Switzerland

Exclusion Criteria:

* Younger than 18 years
* Not living in Switzerland and not receiving MS care in Switzerland
Effects of Ladder Training Versus Plyometric Training Program

A team sport such as cricket consists of irregular sequences of high- and low-intensity motions utilising different metabolic pathways. Athlete performance in this sport is correlated with every facet of physical fitness, including muscular strength, agility, speed, anaerobic power (vertical leap), and aerobic capacity. All aspects of physical fitness, such as aerobic capacity, anaerobic power (vertical leap), agility, speed, and muscular strength, are related to success in this sport. Plyometric training that is repetitive and intermittent has been recommended as a useful tactic for cricket-specific training regimens. Plyometric exercise training is a type of workout regimen designed to enhance nervous system functioning and generate powerful, quick movements, ultimately improving sports performance. Plyometric training aims to increase muscular explosiveness, which enables an athlete to run more quickly, leap higher, or exert force more quickly. Because it takes into account the aspects of strength, power, balance, agility, coordination, core and joint stability, foot speed, hand-eye coordination, response time, and mobility, ladder training is a multidirectional kind of exercise. During ladder training, the four fundamental abilities utilized are running, skipping, shuffling, and leaping. These ladders are lightweight and portable, making them easy to carry and use both indoors and outdoors. The player's footwork will be significantly enhanced, leading to an increase in quickness, agility, and coordination following consistent use of various speed ladder training.

A team sport, cricket combines high- and low-intensity motions employing different metabolic pathways on occasion. Ladder training is a multidirectional type of exercise because it combines the elements of strength, power, balance, agility, coordination, core stability, and joint immovability. In many sports where the ability to leap, run, and change direction is required, plyometric training is used to enhance physical performance. These two have proven useful in helping athletes train for a variety of sports.

The study's goal was to compare the benefits of a plyometric training program vs a ladder training program on the agility, speed, and power of domestic female cricket players. The 42-person research sample was chosen at random. Two groups were created from the sample: group 1 received ladder training, while group 2 received plyometric training. The agility T test, the vertical leap test, and the 30-meter dash test were the result procedures. Following an 8-week course of therapy, the patients' outcome factors were evaluated.

Eligibility Criteria:
Inclusion Criteria:

* Age ranging from 18-25 year.
* Only female cricket players.
* Player with minimum 1- year experience of cricket.

Exclusion Criteria:

* Any cardiopulmonary problem.
* Lower extremity injuries of last 6 months(fractures, ligament ruptures).
* Players who were unable to complete ladder and plyometric training.
Impact of Procedure Materials on Patient Anxiety, Depression, and Pain in Prostate Biopsy Consent

The gold standard for diagnosing prostate cancer is an ultrasound-guided prostate biopsy. Despite its low complication rates, the procedure can cause significant stress, discomfort and anxiety in patients. This study aimed to determine whether visually introducing the materials (ultrasound, probe, biopsy needle) used during the biopsy could reduce patient anxiety and increase comfort.

Forty patients suspected of having prostate cancer were included in this prospective study. All patients received detailed information about the procedure, but they were divided into two groups. The first group was shown photographs of the devices alongside the written consent form, while the second group received only the written consent. The study compared the pain, depression and anxiety scores between the two groups

Eligibility Criteria:
Inclusion Criteria:

- patient's clinical data indicated the need for a prostate biopsy

Exclusion Criteria:

* included having a diagnosis of psychiatric illness
* having previously undergone a prostate biopsy under local anesthesia
* being a patient under active surveillance for prostate cancer
Mod of Cognitive Flexibility by tDCS, Tyrosine Polymorphisms in the COMT Gene

The current study would examine whether increases in endogenous dopaminergic activity via tyrosine and the (presumed) excitation of these by anodal tDCS of the dlPFC could causally be related to cognitive flexibility as measured by task switching and reversal learning.

Additionally, the study will test whether the Val158Met-polymorphism in the catechol- O-methyltransferase (COMT) gene could also predict the effect of TYR supplementation, as this gene is involved in DA degradation in the prefrontal cortex.


Eligibility Criteria:
Inclusion Criteria:

* • Either male or female

  * Between 18 and 30 years
  * You are in good health
  * You agree to fast overnight prior to testing

Exclusion Criteria:

* • Are suffering from cardiac, hepatic, renal, neurological disorders

  * Damaged or diseased skin on your face and scalp, or a sensitive scalp
  * A history of alcohol or drug addiction, or severe psychiatric illness
  * Drug treatment which may lower seizure threshold (i.e. epilepsy)
  * Pregnancy
  * Sleep deprivation (less than 6 hours a day)
  * A history of migraine or headaches
  * A history of taking antidepressants
  * A history of taking tyrosine supplements
Shanghai ST-segment Elevation Myocardial Infarction Cohort

ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and standardized medical treatment.To improve the prognosis of STEMI patients, the management in their hospitalization should be optimized, including improvements in risk stratification, more widespread use of an invasive strategy, implementation of care delivery systems prioritising immediate revascularisation through PCI (or fibrinolysis), advances in antiplatelet agents and anticoagulants, and greater use of secondary prevention strategies such as lipid-lowering therapy.

This study aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.

This study is a prospective cohort study. It aims to standardized the management of STEMI patients and improve the prognosis of the STEMI patients.

Eligibility Criteria:
Inclusion Criteria:

* ST elevation myocardial infarction
* Coronary angiography and percutaneous coronary intervention within 12 hours of symptom onset
* Capable and willing to provide informed conset and capable of completing study visits

Exclusion Criteria:

* Cardiovascular shock at admission
* Severe physical disability
* Active malignant tumors
* Active autoimmune diseases
Effectiveness of Buspirone and Motivational Enhancement Therapy for the Treatment of Marijuana Dependence - 1

This study will assess the effectiveness of a combination of buspirone and motivational interviewing therapy in the treatment of marijuana dependence.

Marijuana dependence is one of the most common substance-related disorders in the United States. Despite its prevalence, there is a lack of clinical research addressing treatments for marijuana dependence. Research has shown that marijuana abuse is associated with affective disorders. This may be caused by repeated use for relief from anxiety. The use of an anxiolytic agent, a drug that relieves anxiety, may help treat marijuana dependence. Motivational enhancement therapy has been shown to reduce marijuana use. Therefore, it is likely that buspirone, which is an anxiolytic agent, combined with motivational enhancement therapy will prove beneficial in treating marijuana dependence. This study will assess the effectiveness of a combination of buspirone and motivational interviewing in the treatment of marijuana dependence.

This double-blind study will last a total of 16 weeks. Participants will be randomly assigned to receive either buspirone or placebo for a period of 12 weeks. There will be one follow-up appointment 4 weeks post-intervention. Baseline assessments will include a physical exam and urine and blood tests. Study visits will occur weekly throughout treatment in order to monitor compliance, assess adverse affects, and obtain substance use data. Mood assessment scales, marijuana craving questionnaires, and a withdrawal symptom checklist will be used to gather the data. Urine drug screens will be collected weekly to test for marijuana use. In addition to this, the presence of opioids, cocaine, amphetamines, and benzodiazepines will be tested at baseline, Weeks 6 and 12, and at follow-up. A 10-day supply of medication will be dispensed to participants each week. Meetings for motivational enhancement therapy will last 30 to 90 minutes each and will occur at baseline, Week 2, and Week 4. Participants' perceived quality of life will be measured at baseline and Weeks 6 and 12 to determine the effect of buspirone.

Eligibility Criteria:
Inclusion Criteria:

* Meets DSM-IV criteria for marijuana dependence
* Lives within 60 miles of the study site
* Willing to provide collateral individuals for contact purposes
* Willing to use an effective form of contraception throughout the study

Exclusion Criteria:

* Meets DSM-IV criteria for dependence upon a substance other than marijuana, nicotine, or caffeine
* Meets DSM-IV criteria for a history of schizophrenia or another non-affective psychotic disorder or bipolar disorder
* Meets DSM-IV criteria for current major depressive disorder or eating disorder
* Significant cognitive impairment
* Currently taking benzodiazepines, antidepressant, or antipsychotic medications
* Major medical illnesses (e.g., HIV, kidney failure, unstable angina, chronic obstructive pulmonary disease, infectious hepatitis)
* Not in stable housing
* Pregnant or breastfeeding
Metabolic Health Benefits of Dairy Protein

The purpose of this study is to evaluate the effects of regular low fat diary consumption on markers of cardiovascular (CV) and metabolic (cardiometabolic) health including body composition (% body fat, body weight), blood lipids, blood glucose, arterial compliance, blood pressure, insulin sensitivity and resting metabolic rate.

This is a multi-centre, randomized, dietary intervention study of 12 months. A total of 100 overweight/obese individuals will be recruited, half recruited in Adelaide, South Australia and the other half from Manitoba, Canada. At baseline, subjects assigned to HD will be given standard serves of low fat dairy products (eg. 250mL milk, 200g yoghurt) on a regular basis for 6 months and asked to incorporate 4 serves/day into their diet. Volunteers randomized to the LD will be asked to continue with their habitual diet and consume less than 2 serves of dairy on a regular basis for 6 months. All participants will be asked to complete a food frequency questionnaire, physical activity diary, 3-day food record, and keep a record of dairy serves (food log) consumed each day. In total, participants will be asked to come to the centre 5 times throughout the study. However, the HD group will be asked to return to the centre every two weeks to receive diary product and return dairy record (food log). At baseline subjects will be asked to attend the Richardson Centre for Functional Foods and Nutraceuticals (RCFFN) fasted for various measurements including: body weight, blood pressure, arterial compliance, dual energy x-ray absorptiometry (DEXA) scan for measurement of body fat, abdominal fat and bone mineral density, waist and hip circumferences and provide a blood sample for the measurement of blood lipids, insulin and glucose.

Eligibility Criteria:
Inclusion Criteria:

* BMI ≥25 kg/m2, assessed as age-related healthy based on pre-study screening examination including:

  * medical history
  * diet and lifestyle history
  * physical measurements (height, weight and blood pressure).

Exclusion Criteria:

* Pregnancy or likely to be pregnant (ionizing radiation from DEXA)
* Weight ≥135kg (exceeds the capacity of the DEXA scanner)diagnosed diabetes or cardiovascular disease
* Liver or renal disease
* Regular use of appetite suppressants
* Irregular use of other treatments which might interfere with the outcomes of the study (e.g anti-hypertensives, statins, thyroxine, omega-3 supplements etc).
Identification of Serum Biomarkers for CD15+ Hypodense Neutrophils in Severe Asthma

The goal of this study is to identify a serum biomarker(s) that can detect increased levels of a population of CD15+ hypodense neutrophils termed low-density granulocytes (LDG) in the blood of patients with severe persistent asthma.

Neutrophils are implicated in the pathophysiology of multiple asthma phenotypes. It was shown in study IST Q4935s that low-density granulocytes (LDG) are elevated in the blood of patients with moderate or severe asthma. The greatest frequency and the highest percentages of LDG were observed in subjects with severe asthma. The LDG, which were first identified and characterized in systemic lupus erythematosus (SLE) patients, have been reported to display increased cytotoxicity for endothelial cells, increased tendency to form neutrophil extracellular traps, and increased production of tumor necrosis factor (TNF). It was also observed that the LDG expressed increased levels of CD15, which can facilitate attachment of activated platelets to the LDG. Identification of a putative serum biomarker that correlates with increased levels of the CD15+ LDG may be useful for the detection of neutrophil-associated inflammation in severe asthma.

Thirty subjects will be screened to identify 20 subjects with severe persistent asthma. The following data and/or samples will then be obtained within three weeks of the clinical assessment: (1) the percentages of LDG will be quantified by flow cytometry; (2) a blood sample will be collected into a PAXgene Blood tube and stored until shipped to Genentech for gene profiling analysis; and (3) a serum sample will be collected for measurement of total immunoglobulin E (IgE) and for future confirmation of potential biomarkers identified in the gene profiling analyses.

Eligibility Criteria:
Inclusion Criteria:

* Physician diagnosis of severe persistent asthma;
* Positive skin test or radioallergosorbent test (RAST) for an aeroallergen;
* Male or female age 12-65 years;
* Non-smoker.

Exclusion Criteria:

* Asthma exacerbation requiring treatment with or increase in oral corticosteroids within 30 days prior to the study;
* Respiratory infection within 30 days prior to the study;
* Starting or requiring a change in allergen immunotherapy within 30 days prior to the study;
* Having been treated with Xolair within the past year;
* Requiring chronic immunosuppressive therapy;
* Having taken methotrexate, gold salts, cyclosporine, or macrolide antibiotics within 3 months prior to study;
* Having taken an investigational drug within 30 days prior to the study;
* Have a history of drug or alcohol abuse;
* Pregnancy
Iron Absorption and Exercise

Iron is a nutritionally essential mineral required for optimal physical and cognitive performance. Endurance exercise often leads to declines in iron status; however, the reason for the decline is not known. The primary objective of the proposed study is to determine the effects of an acute bout of strenuous endurance exercise on iron absorption and status and markers of inflammation in human volunteers. The investigators hypothesize that an acute bout of strenuous endurance exercise, compared to rest, will reduce iron absorption, resulting in diminished iron status, and that reduced iron absorption will be negatively associated with markers of inflammation. A secondary objective is to monitor iron status throughout a season of competition.


Eligibility Criteria:
Inclusion Criteria:

* Members of the Florida State University Cross Country team
* Refrain from using any pain-relievers (e.g., acetaminophen, nonsteroidal anti-inflammatory drugs such as aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product on the 2 study days
* Refrain from using vitamin or mineral supplements on the study days

Exclusion Criteria:

* Musculoskeletal injury that compromise the ability to exercise
Feasibility of At-Home Telehealth Yoga for Treating Chronic Pain

This feasibility study will evaluate yoga as a treatment for chronic musculoskeletal pain. The experimental treatment is yoga delivered via a tablet computer to participants at home ("teleyoga"). First, the investigators will develop a suitable protocol for teleyoga. Second, the investigators will demonstrate the feasibility of conducting a randomized controlled trial involving randomization to teleyoga or in-person yoga groups.

The first phase of the study is not randomized. In this phase, the first group of participants (n=10) will all participate in a tele-yoga class using an iPad loaned to them by the study. They will attend this treatment session from the comfort of their home or a location of their choice. Yoga treatment will last 12 weeks. At the end of treatment, veterans will provide feedback by completing a satisfaction questionnaire to rate various aspects of the teleyoga (e.g. technical challenges, ability to perform yoga through the video-conferencing platform, problems that occurred, and recommendations to improve the class, etc). The teleyoga protocol will be modified on the basis of this feedback and will be tested on a second group of participants (n=10). The second phase of the study will involve randomization of a further group of participants (n=30) to either the teleyoga developed in phase one, or in-person yoga.

Eligibility Criteria:
Inclusion Criteria:

* Veteran
* Medical clearance for participation by VA primary care provider
* Diagnosis of musculoskeletal pain \> 6 months
* Minimum pain intensity of 4 at screening on 0-10 scale
* Any psychotropic treatments stable for at least 4 weeks before study
* English literacy
* Wireless Internet connection at home

Exclusion Criteria:

* Current participation in another clinical trial
* Back surgery within the last 12 months
* Back pain related to a specific underlying cause, disease, or condition
* Baseline pain \<4 or \>9 on 0-10 scale
* Unstable, serious coexisting medical illness
* Unstable, serious coexisting mental illness
* Attended or practiced yoga ≥1 time in the past 12 months
* Active current suicidal plan or intent