cyrilzakka/clinical-trials huggingface dataset:
HIV-Tb Confections Among HIV Patients

A cross sectional study would be done for prevalence of HIV-Tb. co infection among patients of HIV enrolled at ART centre, Khagaria, India, during June' 2015 to May' 2016. A comparative study of CD4 (cluster of differentiation 4) T cell count among HIV-Tb. co infected patient and HIV patients would be taken in account.

Introduction

HIV infection increases the susceptibility of Mycobacterium Tuberculosis (M.Tb.) infection, and hastens its progression due to changes in immune status of the patients. In fact, tuberculosis is now the most common opportunistic infection in patients, who die from AIDS. Immune response in tuberculosis and other infections induces cytokines that enhance replication of HIV, and derives the patient to full blown AIDS. the prevalence of HIV/Tb co-infections have been reported to 0.4% to 20.1% from different regions of northern part of india. India is one of the six countries, those are accounted for 60 percent new cases of tuberculosis, and the BRICS countries collectively account for approximately 50 perce

nt cases of worldwide tuberculosis. The prevalence of multidrug resistant tuberculosis(MDR-TB.) is two-threefold higher in HIV co-infected patients; as HIV infected people rapidly acquire the active disease including resistant strain of M. Tb. and rapidly transmit the disease among population including PLHIV, who in turn, manifest the active drug resistant tuberculosis.

Methods

* This is cohort study among patients of HIV, attending ART (Antiretroviral therapy) center khagaria, Bihar, India during June' 2015 to May' 2016.
* Patients enrolled at the centre were subjected to screening for Mycobacterium tuberculosis infection by doing ESR, mantoux test, chest x-ray, sputum examination for acid fast bacillus (AFB) and nucleic acid amplification test.
* HIV/Tb co infected patients were given cotrimoxazole.
* Patients' data-for example, age, sex, co infection with tuberculosis would be recorded.
* Sputum positivity, radiological features, and extra pulmonary manifestations would be recorded and statistical analysis would be done
* Statistical analysis, such as, mean, standard deviation(SD), student T test, p-values would be done. P-value significance would be measured at p \< .05.

Eligibility Criteria:
Inclusion Criteria:

* Patients of HIV+ enrolled ART centre

Exclusion Criteria:

* Lost to follow up patients (LFU)
* Patients died before the treatment started
* Children below 5 years
Evaluating the Ease of Application, Removal, and Comfort of Gradusox™

The aims of this study are to evaluate the comfort, and ease of application and removal, of GraduSOX™ compression stockings compared to standard compression stockings of the same compression class.

After being informed about the study, all participants giving written informed consent will be randomised by closed envelope randomisation to either a) GraduSOX on their right leg and Sigvaris on their left leg, or b) Sigvaris on their right leg and GraduSOX on their left leg. At Day 1, participants will attend the clinic and be fitted with their stockings and given an Evaluation Form. The Evaluation Form has four sections to be completed on Day 1, Day 2, Day 4 and Day 8 of the study. Each section asks multiple choice questions related to the comfort and ease of applying and removing each stocking.

Eligibility Criteria:
Inclusion Criteria:

* Adults aged 18 and over.
* Have known previous venous insufficiency that has been treated.
* Have no known current contraindication to the wearing of graduated compression hosiery.
* Have an ankle brachial pressure index (ABPI) between 0.8-1.2.
* Have no active ulceration.
* Are physically able to apply and remove hosiery kits safely.
* Have had successful surgery at The Whiteley Clinic and have had at least one follow-up to show no residual venous disease.

Exclusion Criteria:

* Under the age of 18.
* Have known arterial insufficiency (an ABPI of below 0.8).
* Have active ulceration.
* Be physically unable to put stocking on their own legs.
* Have signs of recent lower limb trauma, active infection, ongoing untreated venous disease, significant ankle oedema.
* Unable to give informed consent.
* Pregnant.
* Fragile skin that may be damaged whilst trying to apply or remove compression stockings.
* Previous DVT or complicated varicose veins that were not able to be completely treated and left residual venous reflux disease.
Investigation of Novel Non-CE Marked Catheter

Hypothesis: Treatment with the hydrophilic coated valved intraurethral catheter up to 16 hours per day is effective, well tolerated and seemingly safe for treatment of women with stress incontinence.

Test persons: Ten to twenty stress incontinent women. Treatment time: Up to two weeks

Demonstrate ease and comfort of device insertion, indwelling and removal. Patient acceptability during use.

Other:

* Symptom and QOL questionnaire.
* Drop out analysis.
* Is the patient motivated to continue using the valve catheter?
* Is the patient motivated to recommend the valve catheter to other stress incontinent women?

Eligibility Criteria:
Inclusion Criteria:

* Willing to participate
* Adult, competent woman who understands Danish.
* SUI as dominant symptom; daily or almost daily.
* Residual urine \< 150 ml.
* POP-Q prolapse ≤ grade 2.
* Negative urine stix/Urine D+R.
* Min. 2 months local vaginal estrogen treatment if the woman is postmenopausal.
* Mobile and self-reliant woman.
* Motivated.

Exclusion Criteria:

* Allergy to the silicone material
* Pregnancy or breastfeeding
* Unexplained hematuria.
* Current inflammatory disorders
* Malignant disorders of the urethra.
* Urethral stricture
* Visual diverticulum.
* AK treatment.
* Prosthetic heart valve surgery.
The Clinical Study of Making the Evidence With Application of Da Vinci-Robot Assisted Low Anterior Resection in Rectal Cancer

The clinical study of making the evidence with application of Da vinci-Robot assisted low anterior resection in rectal cancer


Eligibility Criteria:
Inclusion Criteria:

* 75 \> age \> 20
* Rectal cancer
* Non-distance metastasis
* Agree with this study

Exclusion Criteria:

* Benign prostate hyperplasia
* Previous history of urinary bladder or prostate gland operation
* Severe erectile dysfunction
* Defined as patients whose erectile scores were less than 10 in a preoperative questionnaire of the International Index of Erectile Function (IIEF)
Impact of Airborne Pathogen Inactivation Devices Using UVGI Against Respiratory Diseases Affecting Retirement Home Residents

RESPROTECT is a RIPH2 category research, prospective, interventional, multicenter, double-blind, cluster-randomized versus placebo device and cross-over. It's main objective is to compare the cumulative incidence of upper and lower respiratory infections between retirement homes (EHPAD) equipped with active UVGI systems and retirement homes (EHPAD) equipped with inactive systems over two winter periods.


Eligibility Criteria:
Inclusion Criteria:

Retirement homes for dependent elderly people (EHPAD):

* Regularly having had cases of upper and lower respiratory infections among their residents in previous years during the winter period
* Being monitored by the same mobile hygiene team (IPAC), with common protocols, or with teams working together to standardize practices
* Having agreed to participate in the study
* Undertaking to respect all the points provided for in the protocol
* Accepting the installation of UVGI air treatment devices and having the technical resources to carry out the installation
* Committing to send all residents or their legal guardian/curator collective information as well as an individual information notice and a form to oppose the collection of clinical and biological data on their infectious status.

The residents of the structures participating in the study must have been informed of this study (themselves, their legal guardian or curator depending on their situation) and not have objected to the collection of health data concerning them, necessary for this study.

Exclusion Criteria:

* Retirement homes (EHPAD) already equipped with another air treatment system (HEPA, ionization, etc.) in shared places
* Establishments that do not wish to be equipped in the areas to be treated
* Retirement homes (EHPAD) having planned a major modification of the structure (extension, renovation, closure, requalification, etc.) during the study, which could influence the study population and/or the UVGI air treatment devices.
Minimizing Pathologic Aspiration in Patients Undergoing Esophageal and Lung Resections for Cancer

The aim of this study is to reduce pathologic aspiration and pneumonia in the perioperative period by providing an oral care and oral hygiene education to patients preoperatively. Patients enrolled in the study will be given a dysphagia screening questionnaire, an oral care package and oral hygiene education. Patients who screen positive for dysphagia will be referred to Speech Pathology for evaluation. The rate of postoperative pneumonia will be determined for those who participate in the study and will be compared to retrospective patient data from our institution.

Aspiration by high risk esophageal and lung cancer patients with either preexisting or post-therapy/post-operative dysphagia leads to morbidity (pneumonia) and mortality following surgery. The aim of this study is to reduce pathologic aspiration and pneumonia in the perioperative period by providing an oral care and oral hygiene education to patients preoperatively. Patients enrolled in the study will be given a dysphagia screening questionnaire, an oral care package and oral hygiene education. Patients who screen positive for dysphagia will be referred to Speech Pathology for evaluation. The rate of postoperative pneumonia will be determined for those who participate in the study and will be compared to retrospective patient data from our institution.

Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing elective esophageal or lung resections for cancer at our institution

Exclusion Criteria:

* None
Meta Self-efficacy Internet Intervention to Improve Work Self-efficacy and Occupational Well-being in Young Employees

This randomized controlled trial aims to test whether enhancing meta self-efficacy through a self-guided internet intervention improves young employees' work self-efficacy and occupational well-being. The trial will evaluate primary (work self-efficacy) and secondary (three dimensions of occupational well-being) outcomes. It is hypothesized that boosting meta self-efficacy will lead to improvements in outcomes, with effects assessed immediately after the intervention, and at 3- and 6-month follow-ups.

This study investigates the efficacy of a self-guided internet intervention designed to enhance meta self-efficacy in young employees. Meta self-efficacy is a psychological resource that encompasses the ability to leverage self-efficacy sources (mastery experiences, vicarious experiences, persuasion, and affective \& physiological states) to boost context-specific self-efficacy. In this two-arm randomized controlled trial, participants (young employees) will be randomly assigned to an experimental group, which will receive internet intervention with activities aimed at enhancing meta self-efficacy, or to a placebo control group, which will receive educational content. Primary and secondary outcomes (including work self-efficacy, job stress, job affective well-being, and work capabilities), as well as the manipulation check (meta self-efficacy), will be assessed immediately after the intervention and at 3- and 6-month follow-ups. The trial aims to evaluate the effect of enhancing meta self-efficacy and explore the impact of factors such as adherence and engagement on the intervention's efficacy.

Eligibility Criteria:
Inclusion Criteria:

* must be between 18 and 30 years old
* must be empolyed (working at least 20 h / week, for at least the prior two months, regardless of the type of contract)

Exclusion Criteria:

* none
Effect of Pumpkin Seeds Phonophoresis on Chronic Non-bacterial Prostatitis

It has been observed that out of all visits to the clinics by the young and middle age men for grievances including the genital and urinary frameworks, about 25% of the visits account for Prostatitis. A significant number of men, aged less than 50, visits to urologist due to Interminable prostatitis. Nevertheless, just 5 to10% of "prostatitis" cases is really caused by a bacterial contamination.

The purpose was to investigate thoroughly the effect of pumpkin seeds oil phonophoresis among males who are diagnosed with chronic non-bacterial prostatitis.

sixty male outpatients diagnosed with chronic non-bacterial prostatitis. Through sample random sampling procedure the total study population was categorized into three treatment groups; Group A, wherein patients received phonophoresis treatment using pumpkin seeds oil; Group B, where members of the group received trans-perineal continuous low-intensity ultrasound; and Group C, in which the participant received placebo low- intensity ultrasound. All of The three groups of the organized trail received their corresponding treatment daily up-to 3 weeks.

For the analysis participants were recruited from a registry of patients with a diagnosis of CNBP. To be included in the analysis a patient must be evaluated with a confirmed diagnosis. They were examined and diagnosed accordingly by a medical practitioner/urologist.

Patients with concomitant infection, autoimmune diseases, diabetes mellitus, cancer, heart problems/pacemaker, implants (metal, silicone, saline), acute and post-acute injury, thrombophlebitis, impaired sensation, psychiatric diseases, and those with well-known contraindications of ultrasound treatment were excluded from the study. Similarly, those with known hypersensitivity to pumpkin seeds oil and its derivatives, along with those who had received other forms of therapies that could influence the therapeutic outcomes of the study were excluded from the study sample.

Eligibility Criteria:
Inclusion Criteria:

* For the analysis participants were recruited from a registry of patients with a diagnosis of CNBP. To be included in the analysis a patient must be evaluated with a confirmed diagnosis. They were examined and diagnosed accordingly by a medical practitioner/urologist. The patients who were included in the study should have normal laboratory findings

Exclusion Criteria:

* Patients with concomitant infection, autoimmune diseases, diabetes mellitus, cancer, heart problems/pacemaker, implants (metal, silicone, saline), acute and post-acute injury, thrombophlebitis, impaired sensation, psychiatric diseases, and those with well-known contraindications of ultrasound treatment were excluded from the study. Similarly, those with known hypersensitivity to pumpkin seeds oil and its derivatives, along with those who had received other forms of therapies that could influence the therapeutic outcomes of the study were excluded from the study sample.
An Observational Study in Children With CLN2 Batten Disease

This is a prospective, longitudinal natural history study to document the progression of ocular manifestations of CLN2 disease among a community-dwelling population of pediatric participants affected by this disease.

CLN2 is a rare disease with limited available ocular natural history data. While current standard of care slows motor degeneration, it is not known to treat the ocular manifestations of disease. This study is planned to document, through prospective data collection, ocular disease progression in children with a clinical presentation consistent with CLN2 Batten disease undergoing current standard of care for their condition. No investigational product is administered in this observational study.

Eligibility Criteria:
Inclusion Criteria:

A participant is eligible to be included in the study only if all of the following criteria apply:

1. His or her legal guardian(s) is(are) willing and able to provide them written, signed informed consent.
2. Has documented diagnosis of CLN2 disease due to TPP1 deficiency, or has a relative clinically diagnosed with CLN2 with the same mutation as the participant
3. Is currently receiving biweekly ERT treatment with cerliponase alfa

Exclusion Criteria:

A participant is excluded from the study if any of the following criteria apply:

1. Has had prior treatment with an adeno-associated virus-based AAV gene therapy
2. Is currently participating in a clinical trial of investigational product for the treatment of CLN2 disease
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study

The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups.

This will enable a practical approach to screening for osteoporosis and the management and prevention of fragility fractures in people with HIV.

In addition, all risk factors commonly associated with fragility fractures and osteoporosis are collected, as is HIV drug history.

Hence, as secondary outcomes, the associations with reduced bone mineral density can be ascertained.


Eligibility Criteria:
Inclusion Criteria:

* 18 years or above Not pregnant Able to comply with study observations and procedures Able to give fully informed consent

Exclusion Criteria:

* Pregnant Less than 18 years of age Unable to comply with study procedures
Exposure to Antibiotics and Incidence of Bacteraemia Caused by Resistant Bacteria

The primary objective of the study is to identify the risk factors of community-acquired bacteremia to resistant bacteria.

As the secondary objectives, the study aims

* to describe the episodes of epidemiology of bacteremia (community-acquired and nosocomial) with inpatient patients in APHP.
* to research a potential correlation between the incidence of community-acquired bacteremia of studied germs and the evolution of antibiotics consumption in general population in Île de France region.
* to distinguish three categories of community-acquired bacteremia: real community-acquired infections, infections beginning in community (patients discharged a community care center within 3 months), the nosocomial infections (patients discharged a health center within 7 jours). Describe the epidemiology of resistance and the differential impact of individual exposure to antibiotics in these three categories.
* to identify, according to pathogens, a temporal threshold from which a prior stay in a health center or HAD would impact on the occurrence of a community-acquired bacteremia with a resistant bacterium.
* to describe prospectively for follow-up of 1 year for hospitalized patients for a community-acquired or nosocomial bacteremia: mortality at one month and 3 months, re-hospitalization for an infectious episode and isolated bacteria during this later episode.

The investigators will study in particularly individual exposure to antibiotics: exposure in 3 months ou in 12 months, cumulative exposure, hospital- and community-acquired exposure, etc.

Eligibility Criteria:
Inclusion Criteria:

For bacteraemia cohort:

All inpatient patients in a hospital of APHP between January 2010 and december 2018 with at least one haemoculture positive.

* presence of at least a bacteremia as primary diagnosis, related diagnosis and associated diagnosis: A40 (streptococcus), A41 (staphylococcus, BGN, anaerobes, others), A32.7 (Listeria), A39.4 (meningocoele), A42.7 (Actinomyces), A02.1 (Salmonella), A54.8 (gonocoque), A48.0 (Clostridium).
* and/or in biological data presence of at least a haemoculture positive to Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Acinetobacter Baumannii, Enterococcus faecium, Enterococcus faecalis, Enterobacter cloacae, Pseudomonas aeruginosa, Streptococcus sp., Salmonella sp., Clostridium difficile.

For control cohort:

Patients cared in a hospital of APHP between 2010 and 2018 without infection. - Patients without infection of CIM-10 bacteraemia as primary diagnosis, related diagnosis and associated diagnosis, without haemoculture positive in microbiology.

Exclusion Criteria:

- Patients aged \< 18 years
Effects of Manual Therapy and Exercise in the Treatment of Ankle Sprains

Objectives: To analyze the effects of proprioceptive and strengthening exercises versus the same exercises and manual therapy on the recurrent ankle sprain management.

Design: A randomized clinical trial with two intervention groups and triple blind.

Settings: University Hospital.

Participants: Fifty-four patients with previous history of recurrent ankle sprains, regular sports practice and pain during the physical activity, randomly assigned to experimental or control group.

Intervention: Control group performed 4 weeks of proprioceptive and strengthening exercises; experimental group performed 4 weeks of the same exercises combined with manual therapy.

Main Outcomes Measures: Pain, ankle instability, pressure pain threshold (PPT), ankle eversion strength, and active range of motion in ankle joint. The measures were taken before, after and one month after the interventions.

The recurrent ankle sprain means the most frequent complication from the ankle sprain and the previous phase of the chronic ankle stability (CAI), which involves between 20 - 41% of all ankle sprains.

Residual pain concerns the first symptom after instability in most of the cases, but patients also show reduced ankle joint position sense, ankle range of motion, and strength of ankle inversion muscles.

Proprioception exercises on multiplane and unstable platforms, as well as strengthening through eccentric exercises report benefits in pain and function, suggesting the active therapy as the most effective treatment instead of passive manual therapy in chronic phases.

However, several studies analyzed the effects of the manual therapy in the management of the ankle sprain recurrence: the posterior gliding of astragalus and the tibiotarsal joint coaptation improved the ankle range of motion, which was related with recurrent ankle sprain and its residual symptoms.

Despite the benefits from active and passive therapy, very few authors up to date investigated the combination of both clinical approach in the recurrent ankle sprain. Literature analyzed the effects of a combined program including exercises to the manual therapy in acute ankle sprain and concluded that the variety in the manual therapy techniques reported more pain release and improved function.

Besides, based on the effects of joint mobilization techniques, the neurodynamic mobilization could be an appropriate therapy, due to the neural distribution of fibular nerve through the ankle joint, but no studies to date to our knowledge included this technique as part of the recurrent ankle sprain management.

This study aimed to analyze the effects of proprioceptive and strengthening exercises versus the same exercises and manual therapy on the recurrent ankle sprain management.

Eligibility Criteria:
Inclusion Criteria:

* Subjects with previous history of recurrent ankle sprain

Exclusion Criteria:

* Subjects with surgical treatment, previous fractures on lower limb and/or adjacent pathologies were excluded from the study