cyrilzakka/clinical-trials huggingface dataset:
Impact of Training on Gait and Strength in Stroke Survivors

Background: A discrepancy between strength gain and gait changes following various training programs aimed at improving gait function after stroke has been noted. A mismatch between the training program and gait parameters could explain this finding.

Objective: To evaluate the impact of an isokinetic-strengthening program, matching the requirements of the affected lower-limb muscle groups involved in the energy generation of gait, to a control intervention, on gait performance and muscle strength.

Hypothesis: The isokinetic training program of the affected lower-limb muscles would produce greater changes in gait performance and strength than a control intervention not aiming at training these muscle groups.

Design: Single-blinded randomized controlled trial.

Participants: A convenient sample of 30 individuals with chronic hemiparesis.

Interventions: Participants were randomly assigned into two groups (n=15), each training three times/week for six weeks. The experimental group trained the affected plantarflexors, hip flexors and extensors concentrically, while the control group trained the affected upper-limb muscles.

Main outcome measures: Baseline values and post-training values, taken at the end of the training program, of maximal voluntary concentric strength, gait speed and peak positive power.


Eligibility Criteria:
Inclusion Criteria:

* have a chronic (six months or more) unilateral stroke
* be able to walk 10 meters independently with or without a cane
* present residual weakness at the affected lower limb
* have an activity tolerance of at least two hours with a rest period

Exclusion Criteria:

* receptive aphasia
* incontinence
* unstable medical condition
* history of injury
* anesthesia at the lower limbs
The Effect of Education Given to Women on Cervical Cancer on Knowledge, Attitude and Belief

Aim: The aim of this study is to reveal the effect of education given to women about cervical cancer on knowledge, attitude and belief.

Material and Method: This randomized controlled study was conducted with 130 who had a public hospital located in Southeast Turkey (51 experimental, 51 control).

Aim: The aim of this study is to reveal the effect of education given to women about cervical cancer on knowledge, attitude and belief.

Material and Method: This randomized controlled study was conducted with 130 who had a public hospital located in Southeast Turkey (51 experimental, 51 control).

In the first stage, the researcher participants were informed about the purpose of the researcher and the questionnaire, and their consent was obtained for participation in the study.

In the second stage, pre-test data will be obtained with the face-to-face interview method of the research data and a questionnaire form. Cervical cancer education will be provided. (The training is in three sessions, each session will last 20-30 minutes. In the training; Cervical cancer, ppt presentation on HPV virus, question-answer method, female pelvic anatomy on the gynecological examination model, gynecological examination, how the Pap Test is done, and cervical cancer pathologies. will be explained )) After the training, the post-test data will be obtained by applying the questionnaire again.

Eligibility Criteria:
Inclusion Criteria:

* least literate, no communication problem women who agreed to participate in the study

Exclusion Criteria:

* literate are women who do not have communication problems (hearing impairment, visual impairment)
Binge Eating and Chromium Study

The purpose of this study is to test the feasibility and preliminary efficacy of a 6-month chromium picolinate (CrPic) treatment trial in binge eating disorder (BED).

Binge eating (i.e., the consumption of unusually large amounts of food with a sense of loss of control) is a common problem with serious public health implications in large part due to its role in obesity. Binge eating leads to weight gain and is common in overweight individuals. Current treatments for binge eating disorder (BED) are inadequate, and previous randomized treatment trials have suffered from high drop out rate due to the adverse effects of pharmacological agents. Chromium picolinate is a dietary supplement that has been shown to reduce symptoms of depression and appetite regulation problems in patients with atypical depression; chromium picolinate also affects insulin regulation and has been shown to improve glucose levels in patients with type-2 diabetes. This pilot study will evaluate the effect of chromium picolinate on binge eating, mood, body weight, and glucose regulation in overweight individuals with BED.

Eligibility Criteria:
Inclusion Criteria:

1. Currently meets DSM-IV criteria for binge eating disorder (BED);
2. Is able to provide informed consent and meet study visit requirements; and
3. Is psychiatrically stable (e.g., no current suicidal or homicidal intent or other psychiatric condition that requires acute intervention).

Exclusion Criteria:

1. Body mass index (BMI) \< 24.9 kg/m\^2 (underweight or normal weight) or ≥ 40 kg/m\^2 (severely obese);
2. Postmenopausal;
3. Age \< 18 or \> 55 years;
4. Pregnant, planning on becoming pregnant during the study period, or lactating;
5. Current psychotropic medication use;
6. Current use of insulin or other medications to control glucose metabolism;
7. Current use of medications known to significantly influence appetite or weight \[i.e., over-the-counter appetite suppressants that contain phentermine or sibutramine, atypical antipsychotic agents with high weight gain liability (such as olanzapine, risperidone, etc), prednisone, etc.\];
8. Fasting glucose level \> 126 mg/dL (indicative of diabetes); and
9. Creatinine level indicating renal insufficiency (\> 1.0 for women; \> 1.2 for men).
Genetic Polymorphisms Associated With CAD

The design and purpose of the current study is to expand and validate previous findings that the IL-1 gene cluster composite genotype patterns potentiate the risk for coronary artery disease (CAD) and cardiovascular events mediated by OxPL and Lp(a). A secondary objective is to validate other, non IL-1 genetic variants associated with CAD.

The conclusions from an earlier study indicate that the contribution of OxPL/apoB and Lp(a) on angiographically documented CAD and CAD events is conditional on proinflammatory IL-1 genotypes. This novel paradigm links the etiology of atherogenesis attributed to OxPL and Lp(a) from genetics to clinical expression of CAD. ILI has also identified the functional IL-1 gene variations that regulate the IL1B gene in a haplotype context and appear to explain over-expression of IL-1β, as well as the expression of other inflammatory biomolecules that are downstream of IL-1β. The functional IL-1 variants have been combined into patterns that have been associated with risk for more severe periodontal disease across multiple ethnic/racial populations. It is also important to test this functional genetic pattern for similar interactions with OxPL and Lp(a) biomarker levels in association with angiographically documented CAD and CAD events. DNA has been extracted from previously obtained subject blood samples (1173 subjects; 18 years to 90 years at entry (coronary angiography)) at the University General Hospital of Ioannina, Greece study site. DNAs will be labeled by anonymized subject ID # (de-identified), and shipped to ILI for genotyping and genetic analysis. Phase II will determine whether other gene variations (SNPs) previously shown in the literature to be associated with CAD and/or CAD-related secondary events can be validated in this study population.

Eligibility Criteria:
Inclusion Criteria: Diabetics and non-diabetics, with or without known CV disease, who are admitted in the Department of Cardiology in the University General Hospital of Ioannina and the Catheterization Laboratory of 1st IKA Hospital in Athens and undergo coronary angiography at ages 18-90 for clinical purposes will be studied. The study includes subjects who; 1) have suspected CAD and undergo a scheduled diagnostic angiogram for clinical reasons, and 2) are hospitalized because of an acute coronary syndrome and thus undergo diagnostic angiography (with or without previous history of CAD).

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Exclusion Criteria: Patients \< 18 years old and \> 90 years old at time of coronary angiography. Patients with a previous history of coronary revascularization procedure or moderate to severe stenosis will be excluded.

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Safety and Efficacy of SPARC1203 in Allergic Rhinitis

This study will assess safety and efficacy of SPARC1203 delivered via nasal spray in patients with allergic rhinitis


Eligibility Criteria:
Inclusion Criteria:

* Male and female patients aged 18 to 65 years (both inclusive) with history of seasonal allergic rhinitis and positive skin prick test

Exclusion Criteria:

* History or presence of perennial allergic rhinitis
* Upper or lower respiratory tract infection 2 weeks before Visit 2
* Significant pulmonary disease other than allergic rhinitis or mild asthma controlled by beta-2-agonists alone
* Immunizations or vaccinations within 4 weeks prior to Visit 1
Children With ADHD Symptoms: Comorbid Conditions, Cognitive and Social Performance

This article reviews social-demographic variables (SDV) including interpersonal and academic and social performance in families and comorbid conditions(CC) which are the most associated with Attention-Deficit/Hyperactivity Disorder (ADHD)in the sample that has been confirmed diagnosis of ADHD and sample with the same symptoms but not confirmed diagnosis of ADHD.

There are no reports of this kind in the Norwegian population with ADHD.

ADHD is one of the largest diagnostic groups in psychiatric health care for children and adolescents in Norway. In the guidelines laid out by the central authorities, ADHD is to be prioritized. As can be seen by the attention this topic is given in the media, good diagnostics and treatment for this group are important for society as well as the individuals who suffer from this. Early diagnosis, proper organization and appropriate treatment have a positive effect on the self-esteem and development of the person diagnosed as well as probable socio-economic benefits for society.

ADHD population shows significant pattern in socio-demographic relations and comorbidity according to the population that is referred to community Mental Health Clinic due another types of psychiatric conditions.

In terms of comorbid states ODD and OCD are most associated with ADHD . The study indicates prevalence of ADHD children (74%) who met criteria for ADHD, Combined Type (ADHD-C, both inattention and hyperactivity-impulsivity symptoms) and the existence of generally low IQ measures with mean value of 85 points. In terms of comorbid states generally were found in almost whole ADHD group (93 %) compared to half of the non-ADHD group. Disruptive Behaviour Disorder, Anxiety /Stress related disorder and Encopresis /Enuresis shows significant difference between the groups. Other comorbid conditions show no significant differences. Social dysfunctions were found in four of five children.

Eligibility Criteria:
Inclusion Criteria:

* clinical symptoms related on diagnosis of ADHD
* age from 6-17 years

Exclusion Criteria:

* retardation
* somatic disorder
Quantification of Exhaled Particles to Identify Airborne Transmission Risks of COVID-19

In this study, the aerosols emitted during various respiratory activities will be quantified in healthy subjects. The differences in aerosol size spectrum and number during tidal breathing, speaking, coughing and singing will be assessed. Subjects with an endogenously high aerosol emission will repeat the respiratory activities wearing face masks with varying particle filter capacity to investigate the aerosol emission reduction.


Eligibility Criteria:
Inclusion Criteria:

1. Able and willing to give written informed consent.
2. Healthy male and female subjects, aged 18-80 years.
3. Body mass index between 18 and 35 kg/m2.
4. FEV1 ≥ 80% predicted.

Exclusion Criteria:

1. Any clinically relevant abnormal findings in physical examination or lung function at screening visit, which, in the opinion of the investigator, may either put the subject at risk because of participation in the study or may influence the results of the study, or the subject's ability to participate in the study.
2. Risk of non-compliance with study procedures.
3. Suspected inability to understand the protocol requirements, instructions and study-related restrictions, the nature, scope, and possible consequences of the study.
4. History of an acute respiratory infection with symptoms such as cough, rhinitis, sore throat, hoarseness or fever, within four weeks prior to the informed consent visit. In case of acute respiratory infection during study participation, the visit may be rescheduled within the allowed time window. Subjects must be asymptomatic for at least 3 days. Re-screening is allowed should the time window be exceeded.
5. History of lung disease including but not confined to COPD, asthma or pulmonary fibrosis.
6. History of latex allergy.
A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects

This study will determine how morbid obesity affects the distribution and metabolism of the drug propofol. The investigators hypothesize that propofol will be distributed and metabolized differently in morbidly obese subjects as compared to normal weight subjects.


Eligibility Criteria:
Inclusion Criteria:

* adult age (ages 18-70)
* body mass index greater than 40 or between 20-25
* American Society of Anesthesiologists Class I, II, or III
* undergoing elective surgical procedure requiring general anesthesia

Exclusion Criteria:

* evidence of cardiovascular or pulmonary disease
* kidney or liver dysfunction
* drug allergy to propofol
* history of difficult airway
* on prescribed or over the counter anxiolytics, antipsychotics, or sleeping aids
* unable to speak or understand English
Observational Study of Oxygen Delivery During a Fractional Fluid Expansion

Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which decrease during a fluid challenge. The maximalization of cardiac output could decrease the oxygen delivery if the haemodilution was too wide. The aim of this study was to describe the oxygen delivery during a fluid expansion conducted for cardiac output maximalization, following actual guidelines.

One group of 20 anticipated patients

Eligibility Criteria:
Inclusion Criteria:

* Adults over 18 years
* Patients in intensive care after cardiac surgery under mechanically ventilation and with oesophageal Doppler

Exclusion Criteria:

* Arrythmia
* Pregnancy or childrens
* Patients without cardiac output monitoring with oesophageal Doppler
* Patients without medical indication for fluid expansion
* Urgency surgery
Effect of Alcohol Consumption on the Success Rates

This prospective, randomized, double-blind clinical trial will be carried out Conservative Dentistry, Faculty of Dentistry, Jamia Millia Islamia. Seventy adult patients (35 alcoholic and 35 non-alcoholics) with symptomatic irreversible pulpits in a mandibular first or second molar will receive an IANB with 2% lidocaine. In case of pain during treatment, the procedure will be stopped, and the patients will be asked to rate the pain on the Heft-Parker scale. The injection shall be considered as successful if the patient reports pain scores less than 55 on the HP scale.


Eligibility Criteria:
Inclusion Criteria:

* Symptomatic carious exposed mandibular first or second molars.
* Alcoholic patients: Patient with low-moderate drinking levels according to the US National Institute on Alcohol Abuse and Alcoholism
* Control patients: No history of alcohol consumption
* Positive and prolonged response to thermal sensitivity tests and electric pulp test.
* Vital coronal pulp on access cavity preparation.
* American Society of Anesthesiologists class I or II medical history.
* Ability to understand the use of pain scales.

Exclusion Criteria:

* Active pain in more than 1 teeth
* Teeth with fused roots.
* Radiographic evidence of an extra root.
* Large restorations with overhanging margins.
* Full crowns or deep periodontal pockets.
* Hypertension or cardiovascular diseases, compromised immunity, active infection or inflammation
* Known allergy or contraindications to any content of the local anesthetic solution or non-steroidal anti-inflammatory drugs (NSAIDs)
* History of known or suspected drug abuse.
* Taking any drugs which could affect the pain perception, e.g, opioids, antidepressants, anticonvulsants, muscle relaxants, anxiolytics, sedatives, nsaids. 23
* Pregnant or breastfeeding patients.
* Patients with asthma, gastric ulcers, bleeding disorders.
Multi-omics Study and Drug Intervention Study of Spondyloarthritis

Spondyloarthritis (SpA) is a type of chronic inflammatory rheumatic disease that mainly affects the spine and peripheral joints, or joints, ligaments and tendons. This disease subtype has the same clinical and immunological features. Further explore the pathogenesis of spondyloarthritis, explore the guiding significance of different imaging examinations for spondyloarthritis, and study the efficacy and mechanism of different drugs for spondyloarthritis.

1. Clinical phenotype research. The clinical phenotype is the symptoms and signs of the disease and its evolution. Through the clinical phenotype research of spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and help to achieve individualization Precise treatment.
2. Transcriptomic research. The key genes and pathways involved in the pathogenesis of spondyloarthritis can be explored through transcriptomic research of spondyloarthritis, which can provide help for early diagnosis and seeking potential treatment methods.
3. Microbiological research. Through the microbiome research on spondyloarthritis, the composition and function of intestinal flora in patients with spondyloarthritis can be deeply analyzed to provide help for diagnosis and treatment.
4. Radiomics research. Through the radiomics research on spondyloarthritis, it is helpful to realize the diagnosis and grading of spondyloarthritis and the evaluation and prediction of treatment.
5. Drug treatment research By studying the therapeutic effects of different drugs in patients with spondyloarthritis, it is helpful to explore the efficacy and mechanism of different drugs on spondyloarthritis, and to achieve precise and individualized treatment.

Eligibility Criteria:
Inclusion Criteria:

* The patient meets the revised AS New York diagnostic criteria or ASAS axial SpA classification criteria.

Exclusion Criteria:

* patients with rheumatoid arthritis, scleroderma, systemic lupus erythematosus and other immune system diseases;
* patients who had received head and neck radiotherapy;
* patients with history of antidepressants and parasympathetic stimulants;
* patients known to be infected with human immunodeficiency virus (HIV) or hepatitis C virus;
* patients with sarcoidosis or tuberculosis infection.
* patients with inflammatory bowel disease or uveitis.
Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD)

This pilot study will assess the efficacy of a pregnancy and contraception education decision aid (DA) for patients with chronic kidney disease to support decisions about reproductive health, and will assess feasibility and acceptability of the intervention to inform future Research Project Grant (R01) level studies.

60 patient participants will receive either a novel DA about pregnancy and contraception in chronic kidney disease delivered by patient's nephrologist or will receive currently available educational materials based on clinic-level randomization. Nephrologists will be trained to deliver the novel decision aid or will provide usual care. Patients will complete a survey about pregnancy and contraception decision making and the acceptability and feasibility of the educational materials after the clinical visit. Intervention nephrologists will be anonymously surveyed after all patients have completed measures, to assess acceptability and feasibility.

Eligibility Criteria:
Inclusion Criteria:

* Any Chronic Kidney Disease (CKD) diagnosis
* CKD defined as abnormality in kidney structure or function for \>3 months and may be manifested by having any one of the following:

  i. Glomerular filtration rate (GFR)\<60 milliliter/Minute (ml/min)/1.73m2, or

ii. A marker of kidney damage (albuminuria \>30 milligrams per gram (mg/g), abnormal kidney histology by biopsy, hematuria, structural abnormalities by imaging (e.g. polycystic kidney disease, horseshoe kidney) or electrolyte abnormalities due to tubular disorders)

- Able to speak and read English

Exclusion Criteria:

* Patients receiving dialysis
* Patients who have a kidney transplant
* Patients that are surgically sterile (tubal ligation or hysterectomy) or currently pregnant
* Patients that have significant cognitive or visual impairment that limits interaction with the decision aid (DA)
An Investigation on the Role of Emergency Departments in Combatting Against COVID-19 in Zhejiang Province

The epidemic caused by the new coronavirus appeared in December 2019 and spread rapidly, and it has had a serious impact on the social development and people's lives in the world. On February 11, 2020, the World Health Organization (WHO) named the infectious disease caused by the virus COVID-19. my country classifies it as a Class B infectious disease, and controls it as a Class A infectious disease. In order to effectively respond to the epidemic, on January 23, 2020, Zhejiang Province first launched a first-level response to major public health emergencies across the country. Some patients with new coronary pneumonia, especially critically ill patients, may go to the emergency department first. Emergency medical staff must identify and isolate patients with new coronary pneumonia in a timely manner while ensuring the treatment of critically ill patients. People face greater unknowns and challenges in the anti-epidemic work. this research Participating in the prevention and control of the new crown pneumonia epidemic through investigations in the emergency department of Zhejiang Province Related conditions, to further improve the hospital's emergency medical service capabilities for reference.

References：

1. Huang CL, Wang YM, Li XW, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China\[J\]. Lancet, 2020, 395(10223): 497-506. DOI:10.1016/s0140-6736(20)30183-5.
2. Zhu N, Zhang DY, Wang WL, et al. A novel coronavirus from patients with pneumonia in China, 2019\[J\]. N Engl J Med, 2020, 382(8): 727- 733. DOI:10.1056/nejmoa2001017.
3. Gupta M, Abdelmaksoud A, Jafferany M, et al. COVID-19 and economy\[J\]. Dermatol Ther, 2020: e13329. DOI:10.1111/dth.13329.
4. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome- related coronavirus: classifying 2019-nCoV and naming it SARS- CoV-2 \[J\]. Nat Microbiol, 2020, 5(4):536-544. DOI:10.1038/s41564- 020-0695-z.
5. Lai CC, Shih TP, Ko WC, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges\[J\]. Int J Antimicrob Agents, 2020, 55(3): 105924. DOI:10.1016/j.ijantimicag.2020.105924.

Eligibility Criteria:
Inclusion Criteria:

* County-level people's hospitals, TCM hospitals and above comprehensive public hospitals in Zhejiang Province;
* Voluntary participation in this study.

Exclusion Criteria:

* Incomplete data