cyrilzakka/clinical-trials huggingface dataset:
Positional Release Technique in Patients With Unilateral Subacute Trapezitis

To assess the effects of positional release technique to improve the cervical range of motion, relieve pain and function in the patient with unilateral subacute trapezitis.

Trapezius pain is the most common muscular pain due to increased stress which results in trapezitis. The trapezius muscle is postural muscle diamond shape highly susceptible to overuse. It helps in extension, neck rotation, and side bending. Trapezitis is frequently caused by bad posture, watching TV or working on computer for a long and use of thick pillo. Passive ROM may be painful and restricted due to protective spasm in muscle. This study will be a Randomized controlled study and will be conducted in Met Life Rehablitation center Lahore. The study will be completed within the time duration of six months . Consecutive sampling technique will be used to collect the data. The sample size of 44 patients will be taken in this study to find the effect of positional release technique in subacute unilateral trapezitis. Patient will be divided into two groups. Mayoficial release therapy and ultrasound will be given to both groups as a baseline treatment. (Group A will be treated with positional release technique, mayofascial release technique and ultrasound while Group B will be treated with mayofascial release technique and ultrasound). All measurements will be taken at baseline and at the end of 2nd week.Each group will be given 3 sessions per week for 2 weeks. Neck disability index will be used to measure function, Numeric pain rating scale will be used to measure pain intensity and goniometer will be used to measure cervical lateral flexion and extension and rotation range of motion. Data will be analyzed on SPSS 25.

Eligibility Criteria:
Inclusion Criteria:

* Pain with less than 3 months duration
* Subjects of sub- acute trapezitis with trigger points
* Taut band palpable in upper trapezius muscle
* Excruciating spot tenderness at one point along the length of the taut band of the upper trapezius muscle
* Restriction in cervical lateral flexion when measured
* Pain increased by elongating (stretching) the trapezius muscle.

Exclusion Criteria:

* Traumatic Neck Injury
* Fracture of cervical vertebras
* Cervical Spinal Cord Compromise
* Cervical Radiculopathy
* Spondylolisthesis of the cervical spine
* A history of heart disease or the presence of a pacemaker
Bis Monitoring Effect on Delirium Occurrence and Nursing Quality Improvement Recovering From General Anesthesia

①Effects of BIS Index (BIS) monitoring on delirium incidence in Post-anesthesia care unit (PACU) in patients undergoing general anesthesia

②Effects of BIS BIS Index (BIS) monitoring on the quality of nursing care in the Post-anesthesia care unit (PACU)

The effect of intraoperative anesthesia depth monitoring on delirium occurrence and improvement of nursing quality in the post-anesthesia care unit (PACU) remains unclear. We aimed to explore the effect of intraoperative anesthesia bispectral index (BIS) monitoring on delirium occurrence and improvement of nursing quality in the PACU for patients recovering from general anesthesia.

This randomized controlled trial included 120 patients, aged 20-80 years and classified as grades I-III according to the American Society of Anesthesiologists. The BIS-guided group (group B) underwent intraoperative monitoring of BIS anesthesia depth (maintained within the anesthetic range \[40-60\]). The depth of anesthesia was not monitored in the non-BIS-guided group (group C). The patients' vital signs were recorded at the beginning of the operation (T0), upon entering the PACU (T1), 15 min after extubation (T2), and after leaving the PACU (T3). Delirium score, emergence period (extubation and PACU observation times), and adverse events in the PACU were monitored. The nursing activity score (NAS) was used to evaluate the quality of care.

Eligibility Criteria:
Inclusion Criteria:

1. age ranging from 20 to 80 years
2. estimated operation time of 2 to 3 h
3. body mass index ≤30 kg/m2
4. normal preoperative heart, liver, lung, and renal function.

Exclusion Criteria:

1. Past cognitive impairment (dementia, cognitive impairment, mental illness or mental disorder)
2. Complex injuries: multiple fractures, chest and abdomen, pelvic and sacral trauma, head trauma, etc
3. Contraindications to intraspinal puncture (coagulation dysfunction, thrombocytopenia, intraspinal space occupation, puncture site infection, etc.)
4. Have a history of acute myocardial infarction or stroke within 3 months
5. Patients with severe liver dysfunction (Child-Pugh C) or renal failure
6. Contraindications to ketamine, such as malignant hypertension
Prevention of Overfeeding During Infancy

The overall goal of this project is to identify strategies to prevent overfeeding during infancy. One objective is to evaluate the impact on intake of allowing the infant greater control over the amount consumed when feeding from a bottle. This will be accomplished via the use of a novel nipple that mimics (functionally) the nipple of a human breast and allows the infant to self-regulate milk flow. The second objective is to evaluate the relationship between parental feeding styles and infant intake.


Eligibility Criteria:
Inclusion Criteria:

* Infant born at \> 37 weeks gestation
* Infant weighed \>2500 g at birth
* Infant is apparently healthy
* Mother speaks English
* Mother is 18 years of age or older
* Mother/infant pair lives within a 10-mile radius around the UC Davis Medical Center in Sacramento, CA
* Mother plans to use a bottle (at least occasionally) to feed her infant before he/she is 3 months old.
Prevention of Locally Advanced NSCLC Radiotherapy Pneumonia by Inhaling Beclomethasone Propionate

Radical radiotherapy is the main treatment of locally advanced lung cancer, and radiation pneumonia is the main toxic effects of radiotherapy. Among them, the fatality rate of severe radiation pneumonia can reach 50%, which is very harmful to tumor patients. At present, the treatment mode of radiation pneumonia is very few, and the therapeutic effect is poor. The prevention of radiation pneumonitis may be the best way to reduce the number of patients with Post-radiotherapy pneumonia. Previous small clinical studies have shown that the incidence of radiation pneumonia in inhaled beclomethasone group (2 /28) was significantly lower than that in oral prednisone group (8 /29) during radiotherapy. The purpose of this study was to compare the efficacy and safety of radiotherapy between the therapeutic group (inhaled beclomethasone during radiotherapy) and the control radiotherapy group (patients received radiotherapy only), especially the incidence of radiation-induced pneumonia within half a year.

To compare the incidence of radiation pneumonia, effect and side effects of radiotherapy in lung between beclomethasone inhalation therapeutic group and control radiotherapy group in patients with locally advanced non-small cell lung cancer (NSCLC) during radiotherapy.

Eligibility Criteria:
Inclusion Criteria:

1. The subjects understood the requirements and risks of the study fully and signed the informed consent form.
2. Aged between 18 and 70 years;
3. Histologically or cytologically confirmed diagnosis of locally advanced non-small cell lung cancer.
4. All of these patients have pointers to radical radiation and can't be treated surgically.
5. ECOG PS of 0-2;
6. Women of childbearing age had negative pregnancy tests and were willing to accept drugs or intrauterine contraception, while men of childbearing age were willing to accept contraception voluntarily.
7. Adequate hematologic function:

   Peripheral blood neutrophil count \> 2000 cells / uL, Platelet count \> 100\*109 / L; Hemoglobin \>9.0g/dL;
8. Blood total bilirubin \< 2 times normal upper limit, blood AST and ALT ≤ 2. 5 times normal upper line;
9. Inosine clearance ≥ 60ml / min;
10. Life expectancy of at least 12weeks.

Exclusion Criteria:

1. With severe or uncontrolled systemic diseases;
2. With a history of asthma, systemic immune diseases, such as the need for long-term hormone treatment in patients;
3. The lung function decreased obviously;
4. Those receiving targeted therapy or biological therapy at the same time;
5. Allergic to beclomethasone propionate;
6. Pregnant or lactating women;
7. Accompanied by uncontrolled diabetes, need to take oral hormone treatment of sarcoidosis and vasculitis, lupus erythematosus and other immune diseases;
8. In recent 5 years has suffered from other tumors: cervical cancer, basal cell carcinoma of the skin, and so on;
9. The estimated survival time was less than 3 months.
Characteristics of Sexual Dysfunction in Patients With Lung Cancer

The general objective of this observational study is identify and describe the type, frequency, and severity of sexual dysfunction in patients with lung cancer and generate strategies for clinical management and oncological follow-up directed and based on the specific findings in this population. The recruitment will be carried out from July 2023 and will be carried out until December 2023, the analysis of the information will be carried out from January to March 2024.

It is planned to develop a study with a larger number of patients with lung cancer, including the population of Spain and Latin American countries to obtain a sample of more diverse and heterogeneous characteristics, with clinical, cultural, and sociodemographic differences. This will make it possible to obtain better and greater data and therefore define the clinical and treatment factors significantly associated with DS in these individuals and obtain a more complete vision of the reality of the problem.

The results of this research will make it possible to carry out interventions specifically directed at this population and to modify the oncological follow-up guidelines currently in force. Likewise, the information collected will serve as the basis for generating new protocols for a multidisciplinary approach, including the participation of psychology and specialists in urology, gynecology, and psychiatry.

The general objective of this observational study is identify and describe the type, frequency, and severity of sexual dysfunction in patients with lung cancer and generate strategies for clinical management and oncological follow-up directed and based on the specific findings in this population. The recruitment will be carried out from July 2023 and will be carried out until December 2023, the analysis of the information will be carried out from January to March 2024.

Eligibility Criteria:
Inclusion Criteria:

* Age greater than or equal to 18 years and less than or equal to 70 years.
* Diagnosis of lung cancer stages IB to IV.
* Having received systemic oncological treatment for at least 3 months or being in oncological follow-up after having received systemic treatment for a minimum of 3 months with stable tumor disease or partial or complete response in images.
* ECOG ≤ 2

Exclusion Criteria:

* Patients with comorbidities (renal failure, cardiovascular diseases or similar) not controlled with corresponding medical management.
* Individuals with physical disability or cognitive impairment that prevents them from completing the electronic data collection form.
In Situ Simulation Training in Transferring Critically Ill COVID-19 Patients

This study aimed to determine the role of in situ simulation training during a pandemic by using standard and high-fidelity mannequins to improve interprofessional communication, skills, and teamwork in transferring critically ill COVID-19 patients.

Fourty subjects were randomly allocated into two large groups, the High Fidelity Simulator group and the Low Fidelity Simulator group. Each group was divided into small groups, consist of 2 doctors and 3 nurses. All subjects underwent the same interactive lectures, and two sessions of in-situ simulation according to their assign group. In-situ simulation and debriefing were performed by implementing appropriate personal protective equipment and social distancing. At the end of each simulation session, each group would underwent a debriefing session, which was performed by an experience instructor. The first simulation was aimed to teach participants skills and steps in transporting critically-ill COVID-19 patients according to the hospital check-list. While the second simulation was aimed to assess skills, team work and communication that participants had learned from the previous simulation, by using assessment tools that had been developed before. In addition to comparing each point in the assessment tool between the two groups, the points that had been earned were also added up to get the overall points for total skills, cooperation and communication score. At the end of the session, learner immediate feedback were also collected using an online feedback form, which provided accountability for attendance, content learning, and course evaluation feedback.

Eligibility Criteria:
Inclusion Criteria:

* in good physical condition
* had no history of involving in COVID-19 patients care
* willing to become study subject

Exclusion Criteria:

* doesn't want to become study subject
Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents

Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old. This study intends to obtain the data related to the behavioral expression of addiction susceptibility genes, adverse childhood experience, cognition, resistance and the use of NPS in adolescents by questionnaire survey (sample size: 200), and then use logistic regression and machine learning to construct an early warning model.

Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model on the use of the New Psychoactive Substances using for adolescents aged 14-35 years old. This study intends to conduct a questionnaire survey (sample size 200) to obtain data related to the behavioral expression of addiction susceptibility genes, childhood adversity experience, cognition, resistance and the use of NPS in adolescents from different regions and different populations. Through data analysis, this study aims to get the weight of different risk factors on NPS use, and then use logistic regression and machine learning to construct an early warning model, so as to screen out high-risk groups. At the same time, the expert group was consulted to establish a risk early warning system to provide a basis for intervention.

Eligibility Criteria:
Inclusion Criteria:

* Adolescents aged 14-35 (including 14,35 years old)
* Agree to participate in the studies

Exclusion Criteria:

* Be diagnosed with psychological or mental illness
* People that are unconscious, emotionally unstable, or unable to communicate normally
* Patients with severe diseases
Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

The purpose of this study is to compare the efficacy of GentleWave versus EdgePro irrigation in the disinfection of infected root canals of human permanent teeth with necrotic pulp.


Eligibility Criteria:
Inclusion Criteria:

* Permanent teeth that are diagnosed with pulp necrosis.
* elected to have a permanent tooth nonsurgical root canal treatment
* Signed informed consent.

Exclusion Criteria:

* Teeth with root fractures or previously root canal treated teeth.
* Teeth with severe loss of structure
* Teeth with vital pulps.
Temperature Change of the Pulpal Floor and Restoration With Preheated Resin Composite (A Randomized Clinical Trial)

clinical evaluation of the effect of preheating BIS-GMA free resin composite at different temperatures on temperature change of the pulpal floor and restorations and compare it with BIS-GMA containing resin composite.

Hypothesis: Could the preheated composite affect the temperature of the pulpal floor


Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women patients of 25-45 years.
* They should have a good oral hygiene level.
* Presence of at least two posterior class I or II carious lesions to be restored with two different composite resin restorations.
* All carious lesions in selected patients didn't close to the pulp in the preoperative radiograph.
* No preoperative pain.
* Normal occlusal contact with opposing teeth.
* No history of periodontal treatment, including periodontal surgery, in the past year.
* All patients had to sign a written consent before being included.
* A good likelihood of recall availability.

Exclusion Criteria:

* patient with severe periodontitis or severe erosion damage.
* patients with a compromised medical history or had received therapeutic irradiation to the head and neck region.
* If analgesics or antibiotics had administered by the patient during the past 12 hours preoperatively as it might alter their pain perception.
* patients reported bruxism or clenching.
* Greater than grade I mobility or pocket depth greater than 5mm.
* Non-restorable teeth or hopeless teeth.
* Immature teeth.
* Radiographic evidence of external or internal root resorption.
* Alcoholic and smoker patients.
* Pregnant or breastfeeding ladies.
* Patients who had physical disabilities, or who are unable to brush their teeth.
* Individuals who had sensitive teeth but with one of the following conditions was excluded from the study, teeth with large restoration, abutment of teeth of removable partial dentures, dental restorations, abutment of teeth of removable partial dentures, enamel cracks, leakage of fillings or other restorations teeth, dental pulp lesions, dental abscesses, pulpitis, and atypical facial pain.
* Patients who had non-carious lesions like attrition, erosion, abrasion or abfraction.
* Patients had participated in a clinical trial within 6 months before commencement of this trial.
* Patients unable to return for a recall appointment.
The Role of the Kidneys and Liver in the Elimination of Glucagon

The study aims to evaluate the kinetics and effect of glucagon in patients with chronic kidney disease and liver cirrhosis and matched healthy subjects, respectively.

In the present project the investigators wish to identify whether the effect, elimination and degradation of glucagon differ between healthy control subjects and patients with Chronic Kidney Disease (CKD) and liver cirrhosis, respectively. By performing glucagon infusions on healthy control subjects and matched subjects with either limited renal and hepatic function, the contribution of both organs to the metabolic clearance rate (MCR) of glucagon can be tested. A primed infusion of stable isotopic labelled tracers will allow the researchers to investigate the effects of the glucagon infusion on the glucose, lipid and amino acid metabolism.

The quantification of the MCR of glucagon will be accompanied by a range of pharmacodynamic measures in order to substantiate whether a potentially altered glucagon MCR inflicts pharmacodynamic changes of glucagon, which could contribute to the pathophysiology of CKD and liver cirrhosis.

Eligibility Criteria:
Inclusion Criteria:

The CKD group

* Men/women between 18 and 75 years of age
* CKD stage 4 or 5
* Normal liver function (alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), albumin and coagulation factor II, VII and X (INR) within normal range,
* Informed consent

The cirrhosis group

* Men/women between 18 and 75 years of age
* Verified diagnosis of cirrhosis - Child-Pugh Score of 5-12
* Normal kidney function (estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73m2 and absence of proteinuria)
* Informed consent

The control group

* Men/women between 18 and 75 years of age
* Normal kidney function (estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73m2 and absence of proteinuria)(plasma creatinine ≤105 micromol/L (µM) for men and ≤90 µM for women)
* Normal liver function (alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), albumin and coagulation factor II, VII and X (INR) within normal range
* Informed consent

Exclusion Criteria:

All groups

* Diagnosis of diabetes and/or HbA1c ≥43 mmol/mol and/or fasting plasma glucose ≥6 mmol/l.
* Previous kidney transplantation with remaining kidney graft
* Present treatment with oral glucocorticoids
* Polycystic kidney disease
* Pregnancy or breastfeeding
* Inflammatory bowel disease
* Surgical procedure within the last 3 months
* Haemoglobin \< 6 mmol/l (women) or \< 7 mmol/l (men)
* First-degree relatives with diabetes
* Any condition that the investigators feel would interfere with trial participation
Nomogram for Predicting In-stent Stenosis After Pipeline Embolization Device Treatment in Patients with Intracranial Aneurysm

Intracranial aneurysms (IAs) are the primary cause of non-traumatic subarachnoid hemorrhage with high morbidity and mortality. Flow diverters, such as pipeline embolization devices (PEDs), are among the most effective methods for treating IAs in recent years due to the maturity of interventional devices and minimally invasive techniques. Unlike conventional stents, PEDs modify the hemodynamics within the parent artery and aneurysm sac, allowing blood flow from the aneurysm sac, thus facilitating endothelialization of the aneurysm neck. As a result, aneurysms are completely removed from circulation with time. However, about 5.1%-38.5% of IA patients develop in-stent stenosis (ISS) even after successful PED implantation. ISS increases the risk of retreatment and ischemic complications, thereby affecting the long-term prognosis of IA patients. Therefore, preoperative determination of the patient's suitability for PED implantation can enhance patient-centered decision-making and improve the long-term prognosis of IA patients.

Although previous studies have evaluated the correlation between certain individual variables and ISS, there are few comprehensive models predicting ISS after PED treatment. Nomograms have been widely used for prediction of tumor survival and cardiovascular events. Nomograms incorporate multiple risk factors for predicting the patient's potential prognosis based on their individual risks. This study aimed to identify the predictors for ISS after PED treatment and to create and verify a nomogram for assessing individual risk.


Eligibility Criteria:
Inclusion Criteria:

1. Patients aged18 to 75 years;
2. IAs patients treated with PEDs;
3. patients whose parent artery did not have significant atherosclerotic stenosis;
4. patients who had at least one digital subtraction angiography (DSA) follow-up.

Exclusion Criteria:

1. Patients missing critical clinical baseline;
2. patients with inadequate DSA image quality for reliable assessment;
3. patients with comorbid cerebrovascular conditions, including arteriovenous fistulas and arteriovenous malformations;
4. patients without any follow-up information.