cyrilzakka/clinical-trials huggingface dataset:
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow

High arterial blood oxygen tension leads to vasoconstriction of retinal vessels, possibly related to an interaction between reactive oxygen species and endothelium-derived vasoactive factors. Vitamin C is a potent antioxidant capable of reversing endothelial dysfunction due to increased oxidant stress. Vitamin C appears to have vasodilatory properties, but the underlying mechanisms are not well understood.

In the present study we hypothesized that hyperoxic vasoconstriction of retinal vessels could be diminished by vitamin C.

Ocular blood flow will be determined by non-invasive methods, including laser Doppler velocimetry and the Zeiss retinal vessel analyser.


Eligibility Criteria:
Inclusion Criteria:

* Men aged between 19 and 35 years, nonsmokers
* Body mass index between 15th and 85th percentile (Must A 1991)
* Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
* Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant
* Normal ophthalmic findings, ametropia \< 3 Dpt.

Exclusion Criteria:

* Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
* Treatment in the previous 3 weeks with any drug
* Symptoms of a clinically relevant illness in the 3 weeks before the first study day
* History of hypersensitivity to the trial drug or to drugs with a similar chemical structure
* History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with, distribution, metabolism or excretion of study drugs
* Blood donation during the previous 3 weeks
Impact of an Effort Rehabilitation Program for Overweight/Obese Children/Teens on Quality of Life and Wellbeing

Obese and overweight children or teens can join the Prevention and Care of Pediatric Obesity and Pediatric Diabetes Organization of Mulhouse. Those patients who are no longer able to exercize because of their physical condition start an effort rehabilitation program at the Organization. The study will evaluate the impact of this rehabilitation program on quality of life and appetency to physical activity for these children and teens.

Because of a National Obesity Plan (2010-2013) initiated by the French government in charge of health, the Pediatric Obesity and Pediatric Diabetes Organization of Mulhouse was created in 2011.

This Organization is in charge of children or teens with:

* severe or growing obesity associated with respiratory, osteo-articular metabolic complications
* comorbidities worsened by obesity

The Organization and the Physical Medicine and Rehabilitation department of the Mulhouse Hospital have worked together to create an effort rehabilitation program for obese or overweight children. The program, aiming movement rehabilitation, is based on reinforcement and endurance activities in a playful atmosphere and in an important motivational dimension. A medical examination is performed before the first session to confirm the patient's ability to follow an effort rehabilitation program. Each session is supervised by a teacher of adapted physical activity.

Eligibility Criteria:
Inclusion Criteria:

* BMI \> 97 percentile
* at least one of the following symptoms :

  * respiratory functional signs
  * orthopedic complications
  * sleep apnea
  * cardiovascular complications
  * metabolic syndrome

Exclusion Criteria:

* lack of motivation
* uncontrolled psychological issue
* ambulatory care more appropriate to treat the same issues
* any related psychiatric pathology likely to worsen with weight loss
* patient or family not committed to therapeutics program
* psychological inability to deal with separation
* behavior disorders making collective activity impossible
Pilot Trial of Peer Support for Bipolar Disorder

This pilot effectiveness trial will evaluate the feasibility, acceptability, and effectiveness of a structured peer support program based on the Certified Peer Specialist Program of the Depression and Bipolar Support Alliance (DBSA).

Bipolar disorder is a chronic and often disabling illness affecting 1-2% of US adults. Peer support programs are an innovative and promising model to reverse demoralization, activate consumers to seek more effective care, develop consumers' self-management skills, and restore participation in work and other social roles. Peer-led programs can address key barriers to dissemination of effective psychosocial treatment. This pilot effectiveness trial will evaluate the feasibility, acceptability, and effectiveness of a structured peer support program based on the Certified Peer Specialist Program of the Depression and Bipolar Support Alliance (DBSA). Following the philosophy of recovery, the intervention focuses on:

* Motivating consumers to develop an expectation of recovery
* Encouraging regular self-monitoring of mood symptoms
* Training consumers to develop self-management skills for symptom control and problem solving
* Activating consumers to be more informed partners in care and more effective self-advocates
* Motivating and assisting consumers to reclaim work and other rewarding social roles

The investigators will use a rigorous research design to evaluate how structured peer support promotes core values of mental health recovery. Impact of the intervention will be judged across a range of outcomes:

* Long-term control of mood disorder symptoms
* Optimal participation in work and other rewarding social roles
* Consumers' perceptions of autonomy and full participation in the treatment process Findings from this pilot study will inform the development of a full-scale effectiveness trial to include a broader range of participants and health care settings.

Eligibility Criteria:
Inclusion Criteria:

* GHC members aged 18 and over with Bipolar Disorder Type 1 or Type 2 and at least 6 weeks during the past 3 months with a depression or mania/hypomania Psychiatric Status Rating of 3 or greater (indicating significant symptoms at least half of the time). Potential participants will not be excluded because of medical, psychiatric, or substance use comorbidity.

Exclusion Criteria:

* Children under age 18.
Spatially Transcriptomics Reveals Molecular Signatures in CRPS

This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).

Participants who meet the diagnostic criteria for CRPS, aged 19\~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).

Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.

Eligibility Criteria:
Inclusion Criteria:

* Meets the Budapest diagnostic criteria
* Consents to participation in this study
* Aged between 19 and 80 years old
* Symptoms and/or signs of sensory, vasomotor, and sudomotor changes

Exclusion Criteria:

* Who do not agree to participate in this study
* Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)
The Effectiveness of Nurse Navigators in Cancer Care

Cancer patients will be recruited from the Taipei Cancer Center of Taipei Medical University. This study was divided into two phases. The first phase adopted cross-sectional study design with questionnaires to analyze the potential predictors of depressive symptoms among cancer patients. The second stage was adopted experimental study design to explore the effectiveness of nurse navigators in cancer care.

The first phase analyze the potential predictors include the following: socio-demographic characteristics, disease characteristics, lifestyle, perceived benefits, cancer patient' experience with medical service, emotional distress, anxiety, and demoralization.

The second phase will be experimental study.Thus, subjects were randomly sampled and divided into 2 groups: experimental group and control group. Subjects in the experimental group will receive oncology case manager care combined with cancer nurse navigator care, while subjects in the control group will be designed as regular care, which only care with cancer case managers. Both groups will receive long-term follow-up analysis (pre-intervention, post-intervention - 3 months, and 6 months). Outcome measures include the following: perceived benefits, emotional distress, depression and anxiety, demoralization, cancer patient' experience with medical service, and medical report indicators (retention rate, completion rate, survival rate, mortality rate, untreated cancer within 3 months).

Eligibility Criteria:
Inclusion Criteria:

1. Cancer patients for the first time at the cancer center clinic of the university hospital
2. Older than 20 years old
3. Ability to communicate and read
4. The case voluntarily participated in the study and signed the consent form

Exclusion Criteria:

1. People with mental disorders who have schizophrenia, personality disorder, mental retardation, or organic brain disorder.
2. Patient with brain metastasis.
3. Patients who receive hospice palliative care or other treatment programs.
Effect of First Rib Mobilization With Balloon Breathing Exercises

As Non specific chronic neck pain is effecting quality of life in many ways, there are many studies evaluating the methods to treat that problem. This study aims to determine Effect of first rib mobilization with balloon breathing exercises in non specific chronic neck pain. Patients would be divided into two groups and both received conventional treatment. Group A got conventional treatment only but Group B got 1st rib mobilization with balloon breathing exercises in addition.

Nonspecific chronic neck pain (NSCNP) is defined as neck pain persisting for longer than 12 weeks or after the healing period or recurring neck pain that intermittently affects an individual over a long time. Due to current life style, 22 to 70% of the population is expected to feel neck pain somewhere in their lives.

People with non-specific chronic neck pain (NSCNP) present with local hyperalgesia, impaired conditioned pain modulation, low quality of life, and psychological disruptions (fear of movement, depressive symptoms, pain catastrophizing) A systematic review and meta-analysis on Respiratory dysfunction in patients with chronic neck pain reports that, patients with Chronic Neck Pain have reduced respiratory muscle strength and pulmonary function compared with asymptomatic individuals, and this difference could be clinically meaningful.

As previous studies provides evidence about effect of MWM on non specific chronic neck pain and also states relation of breathing dysfunction in NSCNP so we aim to determine effect of first rib mobilization with balloon breathing exercise in addition to conventional treatment in non specific chronic neck pain.

Patients would be divided into two groups and both received conventional treatment. Group A got conventional treatment only but Group B got 1st rib mobilization with balloon breathing exercises in addition.

Eligibility Criteria:
Inclusion Criteria:

* Age group 18-45 years
* Gender: Male, Female
* Patients with non-specific chronic neck pain referred by physician or orthopedic surgeon
* Computer users, mobile users and those with routine of prolonged sitting

Exclusion Criteria:

* Any H/o neurological or vestibular disorders.
* Any H/o Cervical Trauma or surgery
* Any history of Physiotherapy treatment for the cervical region within the previous three months
* cardiac or respiratory insufficiency
* Pregnancy
* Neoplasm
A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin

In this clinical one-site investigation the performance and safety of a skin preparation device will be evaluated for removing hyperkeratotic skin prior to further medical treatment. Comfort and pain during skin preparation, as well as performance and safety of device, will be compared to comparators on separate skin areas for every subject.


Eligibility Criteria:
Inclusion Criteria:

* Attending the clinic for treatment of actinic keratosis using daylight photodynamic therapy
* Age: 18 - 100 years.
* Available for two follow-up visits: two weeks after treatment and 4 months after treatment
* Provision of informed consent i.e., subject must be able to understand and sign the patient Information and Consent Form
* Subject have been informed on the nature, the scope and the relevance of the study

Exclusion Criteria:

* Known or suspected allergy/hypersensitivity to phenol formaldehyde
* Wound at the skin site to be treated
* Documented skin disease at the time of enrollment, as judged by the investigator
* Previously enrolled in the present investigation
* Inclusion in other ongoing investigations simultaneously that would preclude the subject from participating in this investigation as judged by the investigator
* Actinic keratosis treatment obtained within last 6 months
* Involvement in the planning and conduct of the clinical investigation (applies to all investigation site staff and third party vendor)
* Any subject that according to Medical Research Act, paragraphs 7-10, is deemed unsuitable for study enrolment.
* Complications that would increase wound risks if investigational product would be used.
Peer Coaching for Low-Income Patients With Diabetes in Primary Care

Patients with diabetes who are counseled by a peer coach (another patient with diabetes) will have improved glycemic control compared with usual care patients.

Peer coaches have controlled diabetes, patient study subjects have poorly controlled diabetes.

Eligibility Criteria:
Inclusion Criteria:

* Diabetes with most recent HbA1c 8 or above in past 6 months.

Exclusion Criteria:

* Dementia,
* Life expectancy less than 6 months,
* Inability to speak English or Spanish.
Comparison of Clinical Performance of the Guardian Laryngeal Mask With LMA Proseal

To compare insertion characteristics of 2 different supraglottic devices (Guardian LMA and Proseal LMA) and to observe any associated complications.

Condition:

The study focuses on the comparison of the ease of insertion, oropharyngeal leak pressure, fiberoptic position and ease of gastric tube placement between the Guardian LMA and the LMA Proseal in paralyzed, anesthetized patients.

Device: Guardian Laryngeal Mask Device: LMA Proseal

Study Type:

Interventional

Study Design:

Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Single Blind (Subject)

Eligibility Criteria:
Inclusion Criteria:• Ambulatory patients scheduled to undergo knee arthroscopy, transurethral resection of bladder tumor, hand, gynecological and general surgical under a short general paralysed anesthesia of less than 2 hours (American Society of Anesthesiologists physical status I-II)

* 18 to 65 years of age
* Mallampati score less than 3
* thyromental distance more than 6.5 cm
* mouth opening more than \>2.5 cm
* a body mass index less than 35 kg/m2;

Exclusion Criteria:

* Body weight 50 Kg
* Pregnancy
* Difficult airway
* Recent history of upper respiratory tract infection and sore throats
* A history of esophageal reflux disease
* ENT surgery
* Laparoscopic surgery
* Inability to understand the Study Information Sheet and provide a written consent to take part in the study.
Effects of Neuro-dynamic Mobilization Techniques on Upper Limb Functions in Pronator Teres Syndrome

The study aimed to determine the effects of neuro-dynamic techniques on upper limb motor and sensory functions and to compare the effects of slider versus tensioner neuro-dynamic techniques on upper limb motor and sensory functions in pronator teres syndrome.

The study aimed to determine the effects of neuro-dynamic techniques on upper limb motor and sensory functions and to compare the effects of slider versus tensioner neuro-dynamic techniques on upper limb motor and sensory functions in pronator teres syndrome.

Pronator teres syndrome is a rare condition and easily overlooked and mistaken for the more prevalent carpal tunnel syndrome. The median nerve may also be squeezed between the heads of the pronator teres muscle in addition to the carpal tunnel. Patients report pain, numbness, or paresthesia over the lateral 3.5-digit area and anterior forearm, which worsens with forced pronation. This condition is most common in the dominant hand or sometimes can be associated with advanced forearm muscle.in our routine clinical practice, The neuro-dynamic techniques is not that common in neurological physical therapy practice so the effects of neuro -dynamics with conventional therapy needs to be evaluated for better outcomes in upper limb functions.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with pronator teres syndrome
* At least 6 working hours/ day
* Positive Tinel's sign at pronator area (Hoffman's sign)
* Positive Pronator teres syndrome test

Exclusion Criteria:

* Any previous history of metabolic disease, liver disease/ diabetes
* History of previous injuries to the cervical spine including radiculopathies and myelopathies as well as spinal stenosis and/or spinal disc herniation
Investigation of the Safety and Efficacy of Eszopiclone in Insomnia Patients

To investigate the safety and efficacy of administration of eszopiclone for 4 weeks in insomnia patients.


Eligibility Criteria:
Inclusion Criteria:

1. Insomnia participants who did not take eszopiclone before assessment
2. Participants who receive assessment by using sleep questionaries
Chronic Non-Specific Neck Pain and Quality of Life

The factors affecting the quality of life in individuals with chronic non-specific neck pain are not fully known in the studies conducted to date. The aim of this study was to examine the factors affecting the quality of life of individuals with chronic non-specific neck pain.


Eligibility Criteria:
Inclusion Criteria:

No history of radicular pain, trauma or surgery in the cervical region,

* Between the ages of 18-65,
* Having neck pain for at least 6 months,
* Not having received any treatment for neck pain in the last year
* Volunteers with chronic non-specific neck pain

Exclusion Criteria:

* Those with any systemic disease
* Those with cervical pathology
* Previous surgery in the neck region
* Those with neuromuscular disease
* Those with rheumatology disease
* Infection
Individualization of Nutritive Sensory Support Of Radiation Therapy

Nutritional deficiency and subsequent weight loss in patients with head and neck cancer is a common problem and a negative predictor of treatment outcomes and mortality, as well as quality of life. Nutritional support for patients is a prerequisite for the successful management of cancer patients. Sensory changes can be side effects of chemotherapy or ionizing radiation, which damages sensory receptors in the area of radiation, disrupts the function of the salivary glands, leading to hyposalivation and a decrease in taste. Individual choice of nutrition based on sensory sensations can significantly improve the quality of life of patients and ensure timely correction of their eating behavior.


Eligibility Criteria:
Inclusion Criteria:

* Age\> 18 years
* The presence of morphological verification of squamous cell carcinoma of the head and neck
* No history of anticancer treatment
* ECOG score 0 - 2
* Life expectancy is more than 3 months
* Normal liver, kidney and bone marrow function
* Absence of severe uncontrolled concomitant chronic diseases and acute diseases (including infectious diseases)
* Absence of pregnancy, lactation
* Initial compliance of patients (according to the consultation of a psychologist and questionnaires) with a signed informed consent

Exclusion Criteria:

* Simultaneous participation in another clinical trial
* Failure to meet inclusion criteria
* The patient's condition is ECOG ≥3, Karnovsky ≤40%.
* Bleeding
* Decay / Abscess in the area of tumor lesion
* Pregnancy or breastfeeding
* Refractory cachexia
* Allergy or intolerance to any of the components of ONS
Structured Physical Training with and Without Cognitive Support for Adults with ADHD

Studies in children and adolescents with Attention-Deficit-Hyperactivity-Disorder (ADHD) have shown that physical exercise can improve the core symptoms of ADHD; inattention and hyperactivity. For adults, the evidence is deficient and there is a great need to investigate whether adults have the same effect on ADHD symptoms of physical exercise, as children and young people have. Adults with ADHD often have a sedentary lifestyle and suffer from obesity and have sleep problems. In a normal population, these problems have been shown to be affectable with physical exercise. START (Support in Activity, Movement and Exercise) is a randomized controlled intervention study where physical exercise is given for 12 weeks, with or without cognitive support. The effect is measured with rating scales as well as cognitive and physical tests. The purpose is to investigate whether START works as a treatment for ADHD in terms of ADHD symptoms and disability, and what impact the intervention has on mental health, physical condition and activity level, body awareness and everyday functioning.

Outcome measures are registered within 3 weeks before and after the end of treatment, after 6 months and 12 months. The randomization takes place in three groups; physical exercise (i), physical exercise and extra cognitive support (ii), and control group on waiting list (iii).


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with ADHD.

Exclusion Criteria:

* Ongoing depression with points on MADRS-S over 21
* Suicidality
* Bipolar disorder
* Psychosis
* Ongoing addiction
* Reported threatening behavior.
* Severe autism that makes group participation impossible
* Inability to read and understand the Swedish language