cyrilzakka/clinical-trials huggingface dataset:
Cognitive Training in Inpatient Treatment for Substance Use Disorders

This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders.

Participants will complete cognitive training sessions on a regular basis during inpatient treatment. Alternate versions of the computer tasks will be compared in a randomized design. Primary and secondary outcomes will consist of changes in cognitive performance before and after the training period.

Eligibility Criteria:
Inclusion Criteria:

* Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health
* Age 18-60
* Fluency in English
* Able to attend scheduled training sessions
* Comfortable using a computer and mouse

Exclusion Criteria:

* Severe cognitive impairment
* Current or past psychosis or diagnosis of schizophrenia
* Photosensitive epilepsy or history of seizures triggered by light
* Legal mandate to attend treatment
Minimally Invasive Liver Surgery for Metastases From Colorectal Cancer: Oncologic Outcome and Prognostic Factors

Only few reports exist on long-term survival after minimally invasive liver surgery (MILS for colorectal liver metastases. No data are available assessing prognostic factors in the era of current modern treatment strategies. The aim of the current study is to analyze the long-term oncologic outcome after MILS for metastases from colorectal cancer and determine prognostic indicators.


Eligibility Criteria:
Inclusion Criteria:

* Patients with CRLM
* Surgery: resection and/or ablation
* preoperative chemotherapy and/or biological agents are allowed
* postoperative chemotherapy and/or biological agents are allowed
* simultaneous colorectal resection is allowed

Exclusion Criteria:

* primary liver cancer
* benign liver tumors
* pregnancy
Sedation for Brainstem Evoked Auditory Response (BEAR) Testing Using Intravenous Pentobarbital

This is a retrospective chart review study (700 charts from 2002 to 2010)of children from 0 to 18 years of age who have undergone Brainstem Evoked Auditory Response (BEAR)testing using midazolam and pentobarbital protocol for moderate sedation. The specific aims of this study are two-fold:

1. to determine the efficacy of intravenous pentobarbital during BEAR testing in the pediatric population using a standardized protocol; and
2. to evaluate the incidence of adverse events (major and minor), paradoxical reaction and failed sedation and identify predictors for failure and adverse events if any.

Sedation Protocol:

* Versed: 0.1mg/kg IV
* Induction: 2mg/kg IV in children \<1 year; 3mg/kg IV in children \>1year
* Maintenance phase: 1mg/kg IV every 3 to 5 minutes with a maximal dose of 8mg/kg or 200 mg

Definition of terms:

* Failed Sedation: A case in which a patient is inadequately sedated after receiving maximum required dosages such that the test cannot be completed.
* Paradoxical Reaction: Also known as 'pentobarbital rage' is defined as a patient experiencing sustained, inconsolable, and severe irritability or combativeness. This can occur anywhere between 30 minutes after administration of pentobarbital to post recovery phase.
* Prolonged Sedation: A case in which either the patient cannot be discharged 3 hours after administration of the last sedating medication. It could also be a case in which patient is not back to baseline in 24 hours.
* Hypoxia: This is defined as a sustained decrease in oxygen saturation (\>30 seconds) of more than 10% from baseline.
* Time to goal sedation: Time in minutes from initial administration of midazolam to the achievement of adequate sedation of the patient/start of procedure.
* Time to recovery: time in minutes from the last dose of pentobarbital to recovery of baseline status.
* Time to discharge: Time in minutes from administration of midazolam to discharge of patient from recovery room.

Eligibility Criteria:
Inclusion Criteria:

* Children from 0 to 18 years of age
* undergoing BEAR testing using midazolam and pentobarbital protocol for moderate sedation

Exclusion Criteria:

* Children greater that 18 years of age
* Patients with incomplete data
Quality of Life in Patients With Nonmelanoma Skin Cancer

The goal of this study is to learn more about the physical discomfort, sensory impairment, depression, anxiety, and interference with relationships, family, and work associated with NMSC via survey questions.

The purpose of this study is to learn more about the physical discomfort, sensory impairment, depression, anxiety, and interference with relationships, family, and work associated with NMSC via survey questions.

Eligibility Criteria:
Inclusion Criteria:

* patients with nonmelanoma skin cancer
* 18 years of age

Exclusion Criteria:

* non-English speakers
* minors
Decision Making in Multiple Sclerosis Care Under Uncertainty

The main objectives of this study are:

i) To determine patient-level, physician-level and health system factors influencing therapeutic decisions in multiple sclerosis (MS) care by applying conjoint discrete experiments.

ii) To determine the prevalence of therapeutic inertia among participating neurologists.

iii) To compare clinical judgement vs. a qualitative or quantitative approach when assessing for a given case-scenario.

iv) To evaluate the influence of decision fatigue in treatment decisions.

The landscape of MS care is changing. Currently, there are over 15 disease modifying agents (DMTs) available to treat MS, with varying availability around the world.

Significant heterogeneity exists in the efficacy and risks associated with these therapies.

Neurologists caring for MS patients face important choices in each medical encounter: 1) continue with the same management, 2) initiate or escalate therapy for a more effective or safer agent, or 3) consider a reassessment within months under the uncertainty of the current status of the patient.

Limited information on how physicians weigh in different factors when making therapeutic decisions.

Physicians (cognitive biases affecting decision making) and health system (e.g. access to an infusion center) factors are the most responsible causes of practice gaps in MS care. The physician's component is the least studied.

Therapeutic inertia (TI) is a common phenomenon in MS care defined as lack of treatment initiation or escalation (e.g. switch interferons or glatiramer to fingolimod /alemtuzumab /natalizumab/ocrelizumab/ etc.) when recommended by guidelines or evidence of disease progression. This phenomenon leads to poorer patient's outcomes, greater disability, and diminished quality of life.

Goals of the study: i) to determine what are the most relevant factors influencing therapeutic decisions among neurologists with expertise in MS care; ii) to asses whether physicians rely on medical information provided in a case scenario versus a quantitative or qualitative estimation of disease progression based on hypothetical models.

Eligibility Criteria:
Inclusion Criteria:

* Actively practicing neurologist
* Expertise in treating patients with multiple sclerosis (at least 12 per year)
* Clinical setting: academic or community institutions, private practice or outpatient clinic
* Certified physicians in their specialty
* Online consent to participate in the study
The Effects of a Fiber-enriched Bakery Product on Glucose, Insulin Values and Appetite

The aim of the present pilot randomized controlled trial is to compare the effects of the following: 1)-panettone enriched with arabinoxylans (p-rich), 2)-panettone not enriched (p-standard) on blood glucose and insulin values, and appetite scores in 10 healthy volunteers.

This is a crossover, randomized double-blind trial. A product enriched with arabinoxylan extracted from threshing (panettone, p-rich, a sweet baked product with a high glycemic index) was developed to assess the impact on metabolic responses and satiety when compared to the standard product (p-standard) .

Ten Caucasian non-smoker healthy adult volunteers were enrolled starting from January 2023.

Participants were randomized to receive either the p-rich or p-standard. The order of administration of each product was randomized using a computer-generated sequence. The day of each test, fasting individuals underwent a blood sample collection, and weight and height measurements. Then, participants consumed 100 grams of the product within 20 minutes, while sitting. Blood samples were collected at 15, 30, 45, 60, 90, 120 minutes after the consumption of each food.

Eligibility Criteria:
Inclusion Criteria:

* non-smokers healthy adults;
* age 20-65 years;
* ability to provide informed written consent

Exclusion Criteria:

* obesity;
* chronic diseases or pharmacological therapies;
* dietary restrictions;
* allergy or intolerance to the tested food
Age-matched Reference Values for Circulating Natural Killer T-like Cells

Few data are so far available regarding the adult normal values of circulating NKT-like cell concentration, and none for the pediatric population. The primary objective of this study is to determine the reference values for NKT-like cells in pediatric and adult patients (derivation cohort). The secondary objective is to validate the results obtained from the adult derivation cohort with those obtained from an adult validation cohort, consisting of a group of healthy adult volunteers.


Eligibility Criteria:
Inclusion Criteria:

* Healthy blood donor
* without acute or chronic pathological conditions
* matched for sex and age with the retrospective adult derivation cohort

Exclusion Criteria:

* a history of immunological or hematological diseases, immunosuppressive or immunostimulant therapies, or ongoing infections
* one of the lymphocyte subpopulations tested out of range
* undergoing surgery or dentistry intervention in the past two months
Total Hip Arthroplasty (THA): Early Load Versus Load Late

In Brazil, several hip surgeries performed, especially total knee arthroplasty, which represents 1.5 million procedures (Penedo, New, 2007). The rehabilitation of these individuals is slow with respect to the march because it requires an aid and not to use the operated leg as support for three weeks, according to conventional methods. After the third week, the support becomes part and after that period (sixth week), the support becomes total. Therefore, and in order to provide better quality of life, the goal of this work is to compare the march in 40 patients divided into two groups of 20 subjects each. In the control group, the treatment approach is the traditional, i.e., without immediate loading, while the other charge will be applied immediately in the operated limb. In order to verify the possible gain in the quality of life of these patients, the SF-36 will be applied. The march will be assessed with the Time Up and Go test and the force platform and the Harris Hip score analyze the function of the hip. Individuals will receive such care at the Institute of Orthopedics and Traumatology, Hospital das Clinicas, Faculty of Medicine, University of São Paulo (IOT - HC - USP). The results of comparisons between the two groups and the clinical findings obtained will be subjected to appropriate statistical tests, guided by the principles of evidence-based clinical practice, seeking to facilitate and improve the lives of these individuals so they can move freely.


Eligibility Criteria:
Inclusion Criteria:

* Patients served by the institution with THA without cement;
* BMI less than 40, ie, present in most class II obesity;
* Patients with diseases such as osteoarthritis and osteonecrosis of the femoral head;
* Absence of systemic involvement;
* Patients with prosthetic type Lépine.

Exclusion Criteria:

* Bilateral arthroplasty;
* Partial arthroplasty;
* Arthroplasties for review;
* Cemented arthroplasties;
* Surgical complications.
Two Points Versus Three Points Turning in Prevention of Bed Sores in Critically Ill Patients

Several studies were searched the preventive measures of bed sores. Although repositioning is the mainstay in most preventive measures, there is no evidence to recommend specific turning regimen.

The aim of this study is to comparative the impact of the two points repositioning in lateral lying position on the right and left versus the traditional three points repositioning on the right, back, and left in the occurrence of bed sores.

This study was conducted on 150 patients admitted to the critical care department of Alexandria Main University Hospital after obtaining an informed consent from their relatives.

The investigators excluded patients who: have active or healed bed sores.

Patients were randomly divided into two groups by allocated randomization:

* Group 1: traditional three points rotation.
* Group 2: two points rotation.

Several studies were searched the preventive measures of bed sores. Although repositioning is the mainstay in most preventive measures, there is no evidence to recommend specific turning regimen.

Aim of the study:

The aim of this study was designed to evaluate the comparative impact of the two points repositioning in lateral lying position on the right and left versus the traditional three points repositioning on the right, back, and left in the occurrence of bed sores.

Patients:

This study was conducted on 150 patients admitted to the critical care department of Alexandria Main University Hospital after obtaining an informed consent from their relatives.

The investigators excluded patients who: have active or healed bed sores.

Patients were randomly divided into two groups by allocated randomization:

* Group 1: traditional three points rotation.
* Group 2: two points rotation.

Methods:

The studied patients were subjected to:

Complete history taking, physical examination, primary ICU diagnosis, routine laboratory investigation and recording Glasgaw coma scale (GCS), use of sedation, vasopressors and mechanical ventilation

Patients in group 1 nursed by traditional protocol \[ two hours on the right side in 30 degree lateral position, two hours on the back and two hours on the left side in 30 degree lateral position\] Patients in group 2 nursed in lateral position with 30 degree two hours on the right and two hours on the left with elevation of the head of bed by 30 degree in the two groups.

both groups were monitored for bed sores incidence, timing and sites of occurence

Eligibility Criteria:
Inclusion Criteria:

* patients admitted to critical care medicine department and expected to have long stay

Exclusion Criteria:

* active or healed bed sores
Hemodynamic Response to Intubation

This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured


Eligibility Criteria:
Inclusion Criteria:

* Patients undergoing elective surgery under general anesthesia

Exclusion Criteria:

* Patient refusal
* Morbid obesity (BMI\>30)
* Advanced systemic disease
* Hypoalbumiemia
* beta-blocker usage
* Anticipated difficult ventilation and/or intubation
A Novel Nomogram to Predict Severity of COVID-19

Investigators use clinical data from a large sample of COVID-19 disease patients to screen out biomarkers associated with disease severity. Then, a novel nomogram model will be established to predict covid-19 disease severity, which could provide important assistance and supplement for clinical work. In the case of extremely shortage of front-line medical resources, patients with potential severe diseases will be timely treated with the help of the novel nomogram model.


Eligibility Criteria:
Inclusion Criteria:

* COVID-19 disease patients confirmed by virus nucleic acid RT-PCR and CT

Exclusion Criteria:

* unconfirmed suspected cases
* Patients during pregnancy and lactation
* incomplete clinical data
* investigators considered patients ineligible for the trial
* Child patients
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination, With or Without Ribavirin, in Egyptian Adults With Chronic Genotype 4 HCV Infection

The primary objective of this study was to evaluate the efficacy, safety, and tolerability of ledipasvir/sofosbuvir (LDV/SOF) fixed dose combination (FDC) with or without ribavirin (RBV) in Egyptian adults with chronic genotype 4 hepatitis C virus (HCV) infection.


Eligibility Criteria:
Key Inclusion Criteria:

* Willing and able to provide written informed consent
* Chronic HCV infection (≥ 6 months) documented by medical history or liver biopsy
* HCV genotype 4 at screening
* HCV treatment naive or prior participation in this study or study GS-US-334-0138 (Cohorts 1 and 2 only)
* Cohort 3 only: HCV treatment-experienced (previously received therapy for HCV infection with an interferon (IFN)-containing regimen, with or without RBV and/or an HCV NS3/NS4A protease inhibitor (PI)
* Body mass index (BMI) ≥ 18 kg/m\^2
* Screening laboratory values within defined thresholds
* Use of effective protocol-approved contraception methods

Key Exclusion Criteria:

* History of clinically-significant illness or any other major medical disorder that may interfere with treatment, assessment or compliance with the protocol
* Infection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV)
* Pregnant or nursing females or male with pregnant female partner
* Clinically-relevant drug or alcohol abuse within 12 months of screening

Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Parents Together: Supporting Parents to Promote Healthy Behaviours in Children

The Parents Together trial aims to determine if the Parents Together program consisting of virtual parent group sessions and coaching calls, will result in better health outcomes for children. The program which is facilitated by a Public Health Nurse seeks to encourage healthy lifestyle behaviours, help build strong family relationships, and promote child development and mental health.

This study will determine whether an intervention combining group-based parenting skills training and public health nurse coaching calls with a focus on healthy eating behaviours and nutrition, activity and sleep, compared to regular health care will lead to improved eating behaviours, movement behaviours, health and mental health in children aged 2-5 years and their caregivers.

Healthy children will be identified through primary care practices participating in The Applied Reearch Group for Kids (TARGet Kids!). Families who participate in this study will be randomly assigned to one of the two study groups that will run for 6-months:

Group A: Receive 8 weeks of group parenting education sessions and up to 4 public health nurse coaching calls. Group B: Receive regular health care.

Eligibility Criteria:
Inclusion Criteria:

Child enrolled in the The Applied Reearch Group for Kids (TARGet Kids!) cohort study Family is able to participate in English

Exclusion Criteria:

Children with a sibling already enrolled in the study Children with severe developmental delay or disability
Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease

The goal of this randomized clinical trial is to investigate the efficacy and safety of antireflux mucosal ablation (ARMA) for patients with refractory gastroesophageal reflux disease (GERD). The trial aim to evaluate :

* Efficacy of ARMA comparing with medical treatment alone (proton pump inhibitor (PPI)), using GERD-Health Related Quality of Life Questionnaire (GERD- HRQL questionnaire), improvement of acid exposure time and DeMeester score
* Safety and complications of ARMA Participants will be randomly divided into 2 groups. The intervention group will be undergone ARMA, and the control group will be undergone sham endoscopic treatment.

The primary endpoint will be symptoms relief (GERD-HRQL decreases \> 50%). The secondary endpoint will be dosage adjustment of PPI, complications, improvement of acid exposure time and DeMeester score.


Eligibility Criteria:
Inclusion Criteria:

* Adults aged over 18 years old
* History of GERD for over 6 months, who had received PPIs for over 6 months but still had symptoms of typical GERD symptoms (GERD-HRQL score of \>8, acid reflux sensation or heartburn), and/or other symptoms as lump throat, night cough, acid related chest tightness (without other possible explanation of these symptoms)
* Acid exposure time \> 6%
* DeMeester score ≥ 14.72

Exclusion Criteria:

* Pregnancy
* BMI\>=35
* Hiatal hernia \> 2cm or Flap Valve Hill grade III/IV
* GERD LA grade C/D or esophageal ulcer
* Abnormal anatomy of esophagus (esophagectomy, stricture, diverticulum)
* Barrett's esophagus with dysplasia
* Esophageal motility disorders
* History of gastroparesis
* Cirrhosis
* Esophageal and gastric varices
* Previous gastric surgery and anti-reflux procedures
* History of scleroderma or dermatomyositis
* Coagulation disorders (Bleeding tendency and coagulopathy)
* History of oncological disease (not active within 2 years)
MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy)

The main reason for this study is to see how the study drug interacts with the body.

It will compare different doses of the study drug with a drug already in use.

Participants will be adults with liver disease that has affected the brain in the past.


Eligibility Criteria:
Key Inclusion Criteria:

A potential participant may only be included if (at screening), he/she:

1. Understands the study and has signed informed consent
2. Is an adult, not pregnant or lactating
3. Has cirrhosis of the liver
4. Has had 1 instance of HE within 12 months
5. Has hyperammonaemia defined as ≥37 μmol/L at screening

Key Exclusion Criteria:

A potential participant will be excluded if (at screening), he/she:

1. Has contraindicated allergies
2. Expects liver transplant within 1 month
3. Has had a liver shunt within the last 3 months
4. Has inadequate kidney, gastrointestinal, or cardiac function
5. Has cancer, infection, lab abnormalities, or any other condition that, per protocol or in the opinion of the investigator might compromise:

   1. the safety and well-being of the participant or potential offspring
   2. the safety of study staff
   3. the analysis of results
Assessment of the New Provox Life System for Pulmonary Health and Quality of Life After Total Laryngectomy

Background: The benefits of using Heat and Moisture Exchangers (HMEs) for pulmonary rehabilitation after total laryngectomy are widely known. However, current available HMEs do not reach the level of humidification capacity of the nose, and patients adherence to using an HME 24/7 is not always possible. Provox Life HMEs and attachments are a new range of HMEs and attachments, with improved humidification/breathability performance, and designed to suit different situations.

Purpose and aim: In this clinical trial, the new Provox Life System was assessed for pulmonary rehabilitation and QoL after total laryngectomy, and compared with currently available HMEs and attachments.

Methods: Forty laryngectomized patients, who were previous users of HMEs, were randomized to Usual Care or Provox Life for 6 weeks, after which a cross-over occurred. Data was collected at baseline, and after the end of each study period. Additionally, patients filled in a diary and tally sheet to record their forced expectorations and coughing.


Eligibility Criteria:
Inclusion Criteria:

* Total laryngectomy, irrespective of pharynx reconstruction method
* 18 years or older
* Provox XtraHME user
* Provox Adhesive user
* Longer than 3 months after total laryngectomy
* Longer than 6 weeks after postoperative radiotherapy

Exclusion Criteria:

* Medical problems prohibiting the use of HME or adhesive
* Active recurrent or metastatic disease (medical deterioration)
* Recent pulmonary infections/unstable pulmonary condition
* Reduced mobility of arms and/or hands, unable to remove an HME
* Unable to understand the Patient Information and/or unable to give Informed Consent
* Insufficient cognitive ability to handle the HME or adhesive
* LaryButton users