cyrilzakka/clinical-trials huggingface dataset:
Effects of a Multi-Ingredient Pre-Workout Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing in Adults.

The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.

Following inclusion, familiarization and baseline assessments, the participants will be randomly allocated to receive either a multi-ingredient, pre-workout supplement (PREW) or maltodextrin (CHO). Thereafter, the participants will follow a 6-weeks resistance training mesocycle, involving three resistance training sessions (Monday, Wednesday and Friday) per week (18 sessions in total). Before and after the 6 weeks of intervention, the following assessments will be performed: (i) Body composition (fat mass and fat-free mass) via air displacement plethysmography (BodPod); (ii) muscle contractile properties on Vastus Medialis and Anterior Deltoids (via Tensiomyography; (iii) muscle structure of the Vastus Lateralis of the Quadriceps and the Elbow Flexors of dominant extremities via Ultrasound; (iv) Maximal Isometric Strength (Isometric Mid-Thigh Pull); (v) Upper and Lower Body Muscular Power (Medicine Ball Throw and Vertical Jump), (vi) Upper and Lower Muscular Endurance (30-Seconds Sit-to-Stand and 30-Seconds 16RM Bench Press), (vii) Immune System (via HemoCue WBC DIFF System).

The supplements will be ingested 15 min before each training session.

Energy Feeling Questionnaire will be filled immediately before warming up.

In addition, Rate of Perceived Exertion to training will be assessed 15 min after the completion of all workouts.

Eligibility Criteria:
Inclusion Criteria:

* Healthy (no injuries, illnesses or medication intake).
* Between 45 and 65 years old.
* Active and familiarised with Resistance Training.

Exclusion Criteria:

* Unhealthy (illnesses or medication intake) or injured.
* Untrained.
* Young (\<45 y.o.) or elderly (\>65 y.o.).
Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma

This laboratory study is collecting and storing samples of tissue and blood from young patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help the study of cancer in the future.

OBJECTIVES:

I. Establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical features and outcomes from well-characterized cohorts of children and young adults with Hodgkin's lymphoma.

II. Provide specimens from diagnosis, early response evaluation, completion of chemotherapy and radiotherapy, long-term follow up, and relapse to study prognostic factors for early response, relapse, long-term outcomes, and identification of new biological targets for therapy.

OUTLINE: This is a multicenter study.

Patients enrolled on Hodgkin's lymphoma (HL) therapeutic clinical trials undergo collection of tumor tissue samples at baseline and at relapse or disease progression. Serum and anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after diagnosis, and at relapse or disease progression.

Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral blood samples at relapse or disease progression.

Patients enrolled more than 1 year after completion of treatment undergo collection of tumor specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation.

Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed Hodgkin's lymphoma (HL) meeting 1 of the following criteria:

  * Newly diagnosed, untreated HL (for patients under 22 years of age)
  * Past or present diagnosis of HL and past or present enrollment on a Children's Oncology Group (COG) or legacy HL clinical trial (for patients of any age)
Impact of Therapeutic Alliance on Dropout in a Naturalistic Sample of Patients With Borderline Pathology Receiving Residential DBT

Participants with Borderline pathology (≥ 3 DSM-IV-criteria) receiving an inpatient Dialectical Behavior Therapy (DBT) program completed a quality assurance questionnaire set assessing demographic information and pretreatment psychopathology during the days of their inpatient stay. Beyond that, changes of therapists were documented.


Eligibility Criteria:
Inclusion Criteria:

* three or more criteria for BPD as defined by DSM-5 (Borderline Personality characteristics; BPC)

Exclusion Criteria:

* inability to contract and consent,
* other severe mental disorders (bipolar disorder, acute psychosis),
* current alcohol,
* illicit or not prescribed drug use,
* simultaneous participation in other treatment studies,
* pregnancy or breastfeeding,
* an inability to negotiate a non-suicide agreement,
* ongoing traumatic contact with the perpetrator, and
* a Body Mass Index \< 16.5.
Dural Puncture Epidural Technique For Vaginal Procedures

25G Dural Puncture Epidural Technique will be compared with Conventional Standard Lumbar Epidural Technique During Anesthesia of Laparoscopic Assisted Vaginal Hysterectomy.


Eligibility Criteria:
Inclusion Criteria:

* Age: 25-55 years old.
* Height: 165 cm.

Exclusion Criteria:

* Patient Refusal.
* Coagulopathy.
* Deformity of lumbar vertebrae.
Donor After Circulatory Death Heart CAP Trial

The Portable Organ Care System (OCS™) Heart for Resuscitating, Preserving and Assessing Hearts Donated after Circulatory Death Continued Access Protocol (OCS DCD Heart CAP)

To enable continued clinical access to DCD heart transplantation in the U.S. and to continue to collect additional data on the performance of the OCS Heart System to resuscitate, preserve and assess hearts donated after circulatory death for transplantation to increase the pool of donor hearts available for transplantation.

Eligibility Criteria:
Recipient Inclusion Criteria:

* • Primary heart transplant candidates

  * Age ≥ 18 years old
  * Signed: (1) written informed consent document; (2) authorization to use and disclose protected health information; and (3) consent to TransMedics' use of recipients' UNOS/OPTN data and recipients' INTERMACS data.

Recipient Exclusion Criteria:

* Prior solid organ or bone marrow transplant

  * Chronic use of hemodialysis or diagnosis of chronic renal insufficiency
  * Multi-organ transplant.
Seprafilm in the Reduction of Incidence of Bowel Obstruction in General Surgery

The purpose of the study is to evaluate the efficacy of Seprafilm in reducing the incidence of bowel obstruction and to evaluate the incidence of all serious adverse events (SAEs) associated with the use of Seprafilm occurring within 30 days postoperatively, and the incidence of abdominopelvic abscess within 6 months postoperatively.


Eligibility Criteria:
Inclusion Criteria:

* Patients who were undergoing colon and/or rectal resections and/or adhesiolysis for treatment of bowel obstruction

Exclusion Criteria:

* Patients with any medical condition or disease where 5-year survival was not expected
* Patients undergoing laparoscopy
* Patients undergoing surgery for treatment of acute abdominal trauma
* Patients with an abscess (abdominal or pelvic) present during the initial surgery
* Patients with a history of pulmonary embolus or deep vein thrombosis (DVT) within 1 year of surgery
Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis

To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.

30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days.

Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.

Eligibility Criteria:
Inclusion Criteria:

* Presence of atleast 20 teeth
* more than 30% of sites with clinical attachment loss of ≥ 5 mm
* non-smokers
* no previous history of periodontal therapy

Exclusion Criteria:

* systemic diseases
* under antibiotics or anti-inflammatory drugs within previous 3 months
* pregnant and lactating women
* allergic to antibiotics
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia

Gastrointestinal tumor is one of the highest incidence of malignant tumors in our country, with the incidence increasing year by year. Laparoscopic gastrointestinal surgery ,due to having less bleeding ,small trauma ,Rapid recovery ,has become the main means for the treatment of gastrointestinal surgery. Under general anesthesia, mechanical ventilation can lead to repeated mechanical dilation of alveoli, which can lead to mechanical injury of alveolar epithelium, reduce lung compliance, affect lung function, and increase postoperative complications and hospital stay of patients. Glycopyrrolate acts selectively on M1 and M3 receptors, and is 3-5 times more selective to M3 and M1 receptors than M2 receptors. Therefore, as preoperative medication for elderly patients, it has less effect on the cardiovascular system and can stabilize the heart rate,compared with atropine.However, its influence on the respiratory system in the field of anesthesia is only limited to the study of inhibiting glandular secretion at present, and there are no clear reports on the study of respiratory mechanics .The purpose of this study was to investigate the effects of glycopyrrolate on lung function and respiratory mechanics in elderly patients after general anesthesia, in order to guide clinical medication.


Eligibility Criteria:
Inclusion Criteria:

1. Elderly patients undergoing elective laparoscopic radical surgery for gastrointestinal malignant tumors;
2. ASA Grade I-III;
3. BMI 18 to 30 kg /㎡；
4. Operation time≥2 hours.

Exclusion Criteria:

1. Hypersensitivity to glycopyrrolate；
2. Clinical diagnosis of hepatic and renal insufficiency；
3. Complicated myasthenia gravis；
4. Prolonged QT interval and other abnormal electrocardiogram；
5. History of mechanical ventilation within six months before surgery；
6. Combined with glaucoma；
7. The patient refused.
Decreasing Depression and Anxiety and Their Effect on QoL of ESRD Patients (End-Stage Renal Disease)

This study evaluates the effect of a single cognitive-behavioral intervention (CBI) in a control group against the same CBI plus the strengthening of resiliency skills in an experimental group, on ESRD patients.

Cognitive behavioral therapy has long been an alternative in the treatment of symptoms of depression and anxiety in patients with chronic diseases such as renal failure, however the combination of therapeutic approaches that include not only pathological but also another more positive approach (as the resilient model), represents a novel proposal for the treatment of negative psychological symptoms and improvement of the quality of life in these patients.

The inclusion of the resilient model in a cognitive behavioral intervention serves as a possibility of therapeutic target that could enhance the effectiveness of the treatment.

Eligibility Criteria:
Inclusion Criteria:

* Older than 18, and younger than 61 years old
* Depression score in the Beck Depression Inventory (BDI) greater than 30 points.
* Anxiety score in the Beck Anxiety Inventory (BAI) greater than 40 points.
* Have not been hospitalized over the last 6 months
* Signing of informed consent

Exclusion Criteria:

* May not be able to communicate in the Spanish language.
* Presence of psychiatric comorbidity (suicide ideation or depressive or anxious).
Study to Evaluate Impact of School-based Influenza Vaccination on School Populations

Rates of confirmed influenza illness in vaccinated and non-vaccinated children will be compared between schools with and without vaccination programs. The investigators hypothesize that in addition to lowering rates of influenza in vaccinated children, raising vaccination rates by 30-40% through school-based vaccination programs will decrease incidence of influenza in non-vaccinated children attending those schools compared to non-vaccinated children in schools with low vaccination rates.

This prospective cohort study will evaluate rates of virologically confirmed influenza in children attending schools with and without school-based vaccination programs. Eight schools (4455 students) in two school districts matched for size, race/ethnicity, socioeconomic status, and location will serve as intervention and control schools. During influenza season defined by local surveillance data, nasal/throat swabs will be obtained for rapid influenza detection assays from all children with fever and respiratory symptoms identified by teachers for evaluation in the school nurse's office. Absent children will be offered testing at a central location within the schools' communities.Rates of confirmed influenza illness in vaccinated and non-vaccinated children will be compared between schools with and without vaccination programs. Rates of absenteeism also will be evaluated. The investigators hypothesize that in addition to lowering rates of influenza in vaccinated children, raising vaccination rates by 30-40% through school-based vaccination programs will decrease incidence of influenza in non-vaccinated children attending those schools compared to non-vaccinated children in schools with low vaccination rates.

Eligibility Criteria:
Inclusion Criteria:

* Children enrolled in target schools

Exclusion Criteria: none
Effects of TEAS on Stress Response During Extubation of General Anesthesia in Elderly Patients

Elderly patients have an increased risk of stress responses during extubation after general anaesthesia for an elective supratentorial craniotomy. How to decrease the stress responses during extubation after general anaesthesia remains challenging for the anaesthesiologist. In this study, we aimed to investigate whether transcutaneous electrical acupoint stimulation (TEAS) might decrease the stress responses and improve the quality of recovery in the elderly patients who underwent elective supratentorial craniotomy under general anaesthesia.

A total of 100 elderly patients scheduled for elective supratentorial craniotomy under propofol-remifentanil total intravenous anaesthesia were randomly divided to either TEAS group (received stimulation at LI4, PC6, LU7, LU5, LI18 and ST9 acupoints, 2/10Hz, 6-15 mA) or Sham group (received no stimulation). The primary outcomes were the haemodynamic parameters and plasma concentrations of epinephrine (E), norepinephrine (NE) and cortisol (Cor). The secondary outcomes were the consumption of remifentanil and propofol, the time from discontinuation of anesthetics to extubation and reorientation, extubation quality score, the quality of postoperative recovery and postoperative complications.

Eligibility Criteria:
Inclusion Criteria:

* ASA Ⅱ～Ⅲ
* aged 60-70years
* scheduled for elective supratentorial craniotomy under general anaesthesia

Exclusion Criteria:

* past or current history of cardiovascular and/or cerebrovascular diseases
* diabetes
* pre-existing liver, lung or kidney dysfunction
* psychiatric disorders
* potentially difficult airway
* previous acupuncture treatment
* infection at the stimulus sites
The Health Effects of Blueberry Anthocyanins in Metabolic Syndrome (the CIRCLES-study)

The purpose of this study is to determine the dose-dependent impact of 6 month freeze-dried blueberry powder intake on insulin sensitivity and resistance, cardiovascular disease risk factors, and lung and cognitive function in overweight and obese participants with metabolic syndrome. We will also examine acute post-prandial effects of blueberry intake (at baseline and at 6-months).


Eligibility Criteria:
Inclusion Criteria:

* Men and postmenopausal women (≥ 1 year since last menstruation)
* 50 to 75 years old
* BMI of ≥ 25 kg/m2
* 3 characteristics of metabolic syndrome i.e: Waist circumference ≥ 102 cm for men, ≥ 88 cm for women; Triglycerides ≥ 1.7 mmol/L (or drug treatment for elevated triglycerides); HDL-cholesterol \< 1.0 mmol/L for men, \< 1.3 mmol/L for women (or drug treatment for low HDL-cholesterol); Blood pressure ≥ 130 mm Hg systolic and/or ≥ 85 mm Hg diastolic blood pressure; Fasting blood glucose ≥ 5.56 mmol/L
* Successful biochemical, haematological and urinalysis assessment at screening

Exclusion Criteria:

* Current smokers, or ex-smokers ceasing \< 6 months ago
* Existing or significant past medical history of vascular disease or medical conditions likely to affect the study measures
* Fructose intolerance or known allergies to the intervention treatments
* On therapeutic diets or having experienced substantial weight loss within 3 months of screening
* Taking flavonoid containing supplements (and unwilling to cease intake during, and 1 month preceding the trial)
* Planning on altering consumption of vitamin supplements / fish oil capsules during the course of the study.
* Prescribed hypoglycaemic, vasodilators or HRT medication.
* Unsatisfactory biochemical, haematological or urinary assessment at screening, or measures considered to be counter indicative for the study
* \< 3 characteristics of the metabolic syndrome.

NB: REC approved NoSA granted to include those on anti-hypertensives (29JUL2014)
Band Adhesions in Relation to Previous Abdominal Surgery

This study investigates the prevalence of previous abdominal surgery in a cohort of patients operated for bowel obstruction and analyzes the causes of obstruction discovered at surgery.

Postoperative intra-abdominal adhesions are a common cause of small bowel obstruction. The extent of adhesions has been assigned to the magnitude of previous surgery. In a county hospital, with a catchment population of 120 000 inhabitants, records of operations performed for bowel obstruction over a period of 70 months were retrieved. Codes for bowel obstruction according to an International Classification of Diseases (ICD-10) will include: Intestinal adhesion with obstruction, Other and unspecified intestinal obstruction, Intestinal obstruction and Peritoneal adhesions. Amount of adhesions will be calculated in relation to previous surgery.

Eligibility Criteria:
Inclusion Criteria:

Subjects operated for bowel obstruction -from January 1st 2006 to October 31st 2011

Surgical codes for bowel obstruction:

* Intestinal adhesion with obstruction
* Other and unspecified intestinal obstruction
* Intestinal obstruction
* Unspecified and Peritoneal adhesions

Surgical procedures identified for bowel obstruction:

* Division of band adhesion
* Adhesiolysis
* Other separation of adhesion during bowel obstruction
* Laparotomy and reposition or detorsion of intestine.

Exclusion Criterias:

-Extra-peritoneal surgery such as inguinal or ventral hernia repair was excluded.
Using Dry Eye As a Disease Model, Investigators Demonstrated the Optimal Selection of Individualized Clinical Interventions and the Superiority of Dynamic Treatment Discrimination in Chinese Medicine.

In this study, dry eye disease (leukoaraiosis) is used as a model disease, and the methodological system for evaluating the clinical efficacy of Chinese medicine for dry eye disease is constructed with the core of "subgrouping dynamic and static parallel group design", so as to carry out a real-world demonstration study of dry eye disease as a dominant disease in Chinese medicine treatment. The purpose of this study is to demonstrate the selection of individualized clinical interventions and the superiority of dynamic diagnosis and treatment using dry eye as a disease model. The study provides a clinical example of a subgroup-based dynamic and static parallel group design for TCM clinical research on "disease-based integrated treatment". Based on the conclusions of the efficacy evaluation study, investigators will provide real-world clinical data of dry eye syndrome for the artificial intelligence prediction of the integrated platform of individualized clinical evaluation and evidence support of Chinese medicine with multi-source data integration.


Eligibility Criteria:
Inclusion Criteria:

* Be 18-75 years of age and of any gender
* Meets Western diagnostic criteria for dry eye
* Formed consent and signed the Informed Consent Form

Exclusion Criteria:

* Those who are unable to perform a dry eye examination due to various factors
* Patients with severe diseases of the liver or renal system, or infectious eye diseases
* Those who are allergic to the medications used in this study
* Women who are pregnant or breastfeeding Mental illness or intellectual disability; Participants in clinical trials of other drugs within the last 3 months.
Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty

The purpose of the study is to determine whether crosslinked Marathon and standard Enduron polyethylene liners show differences in bone loss around the hip implant.

Several institutions report very low wear rates with highly crosslinked polyethylene based on early clinical data. However, since bone loss typically appears after 5-year follow-up, the reduction in the incidence and extent of bone loss among total hip replacement patients with crosslinked Marathon liners, compared to those with standard Enduron liners, has not been as dramatic as the wear reduction. Despite the substantial reduction in wear that we observed at 5-year follow-up, the patients' perceptions of their outcomes remained similar among the Marathon and Enduron groups. This study will evaluate outcome at a minimum of 10-years after surgery among the same group of patients whose outcome was previously reported at 5-year follow-up. At 10-year follow-up, we anticipate that the reduction in wear associated with Marathon polyethylene will be associated with significant reductions in bone loss when compared to the Enduron polyethylene.

Eligibility Criteria:
Inclusion Criteria:

(from original study)

-Elective total hip replacement patient

(from 10-year follow-up)

* Consented to the original study.
* Received a Duraloc 100 cup with either a crosslinked Marathon or standard Enduron liner.
* Received an AML/Solution or a Prodigy stem with 28mm cobalt chrome femoral head.

Exclusion Criteria:

(from original study)

-None

(from 10-year follow-up)

* Patient did not receive device as specified in inclusion criteria.
* Patient refused to consent to the 10-year follow-up.
SARS-CoV-2 (COVID-19) Immune Surveillance Among a Population Based Sample of Adults in Florida

The overall goal of this study is to understand the immune response (IgG) to SARS-CoV-2 to fill critical knowledge gaps in the natural history of this virus and to inform the development of future infection mitigation efforts. The study team aims to assess the prevalence of circulating IgG antibodies to SARS-CoV-2 and the factors associated with sero-prevalence. These data will be used to estimate the total population that has been exposed to the virus (asymptomatic and symptomatic), the proportion of the population that may be protected by natural immunity, and the proportion that is susceptible. Data obtained from this research will be shared with the Florida Department of Health.


Eligibility Criteria:
Inclusion Criteria:

* Resident of Hillsborough County, Florida
* 18 years of age or older
* Currently not exhibiting symptoms of SARS-CoV-2 infection