cyrilzakka/clinical-trials huggingface dataset:
The Influence of Gender on Dual Task Performance in Young Healthy Adults

Dual tasking (DT), or the act of conducting multiple, simultaneous tasks, is wide spread in daily life .In particular, the vast majority of mobility tasks we complete (e.g., standing, walking, stepping, etc.) occur while distracted by another motor and/or cognitive task. A common feature of DT is that performance on one or both tasks is diminished when completed together .Understanding the relationship between gender and dual task performance is important because this knowledge could help inform us the development of interventions or training programs that target these differences and improve overall performance. Aims: To investigate the gender-related differences in single task performance through motor torque, cognitive tasks and walking speed, and the combined dual-task costs considering both motor and cognitive performance in a sample of young adults

gender differences on dual task performance in young healthy adults. Dual task performance refers to the ability of an individual to perform two tasks simultaneously, which can be a challenging cognitive task because the human brain has a limited capacity for attention and processing. When an individual attempts to perform two tasks at once, they must divide their attention and resources between the two tasks, which can lead to decreased performance and increased errors.

The study will evaluate motor performance, muscle force production, and average speed through a walking test. Sixty non-athlete participants (30 female and 30 male) will be recruited, and ANCOVA will be used for statistical analysis.The participants will perform the following tasks: single mobility tasks (average speed through walking test for 45 seconds), single muscle force production, single cognitive task, dual-task condition: walking test and cognitive task, and dual-task condition: muscle torque test and cognitive task

Eligibility Criteria:
Inclusion Criteria:

* age 18-30
* BMI 18-25
* normal knee range of motion at time of test

Exclusion Criteria:

* participants had been excluded if they were taking any medications, showed a musculoskeletal injury to the leg, had a cognitive impairment, had a history of surgery, had a cardiovascular condition, or had any other health issue that would have an impact on their physical ability.
Electrical Stimulation in Peripheral Arterial Disease

The investigators wish to investigate the effects of neuromuscular stimulation on intermittent claudication.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of stable intermittent claudication (\>6 months) with confirmation by medical imaging
* ABPI\<0.9
* Absolute walking distance \<500m

Exclusion Criteria:

* Pregnancy
* Cardiac pacemaker
* Previous lower limb major amputation
The Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes

Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at Prentice Women's Hospital. Optimizing the variables which could affect fetal heart rate patterns at the time of initiation of analgesia, such as fluid administration and oxytocin management, could help us provide better care for our patients and their fetuses.

Hypotheses: The combination of fluid administration and lower doses of oxytocin administration will have fewer adverse fetal heart rate changes in the first 60 minutes following initiation of labor analgesia.

After obtaining informed, written consent, candidates were randomized to one of four groups at the time of request for labor analgesia. All subjects received a maintenance infusion of Lactated Ringers(LR). For candidates in Groups A or B, an intravenous bolus of 1000 mL of LR was initiated. Candidates in Groups C and D did not receive any additional fluid. If randomized to group A or C, the oxytocin management was continued as per the normal active management of labor protocal (AMOL). If randomized to groups B or D, the dose of oxytocin that was being administered was halved and not increased until 60 minutes after the initiation of epidural analgesia. Fetal heart rate monitoring and frequency of uterine contractions were recorded by external tocodynamometry.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-60
* Healthy nulliparous or multiparous women
* Term (\>36 week gestation)
* Singleton pregnancy
* Spontaneous labor or with spontaneous rupture of membranes
* Receive oxytocin
* Request neuraxial analgesia

Exclusion Criteria:

* Under 18 years of age
* Presence of any systemic disease (e.g., diabetes mellitus, hypertension, preeclampsia)
* Use of chronic analgesic medications
* Prior administration of systemic opioid labor analgesia
* Non-vertex presentation
* Induction of labor
* Contraindication to neuraxial analgesia.
Efficacy and Safety of Covid-19 Vaccine in Cardiac Patients

Efficacy and safety of covid-19 vaccine in Cardiac patients

investigate the efficacy and safety of covid-19 vaccine in cardiac patients and its possible assocciated morbidity

Eligibility Criteria:
Inclusion Criteria:

* Subjects diagnosed as STEMI undergo PPCI as (Fourth universal definition of myocardial infarction (2018) Kristian Thygesen) 10
* with age range from 18 to 80 years after 1 month of STEMI .

Exclusion Criteria:

* Patients with previous covid infection confirmed by swap or CT chest or ICU addmision.
* Patients with previous covid infection confirmed by qualitative antibdy test .
* Patients with history of anaphylaxis to any component of the vaccine should not take it .
* patients with febrile illness or acute , ongoing infection .
* immunosuppressive diseases .
6-Session Treatment for Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition that is characterized by excessive and uncontrollable worry and anxiety. In Canada, 3 to 4% of the population suffer from GAD at any point in time. These individuals have a lowered quality of life and are at risk for many medical conditions such as coronary heart disease and cancer. Research suggests that both pharmacological and psychological approaches are effective for treating GAD in the short-term; however, psychological treatments appear to offer the greatest long-term benefits. There exist a number of effective psychological treatments for GAD, most of which fall into the category of cognitive-behavioural therapy or CBT. In the 1990s, a group of Canadian investigators developed a CBT protocol for GAD that included four components. Data from five clinical trials suggest that one of the four components is particularly important for treatment success: experiencing uncertainty rather than avoiding it in everyday life. Stated differently, learning to tolerate and deal with uncertainty appears to be the key to decreasing worry and anxiety. Given this finding, the investigators have developed a new treatment that exclusively targets intolerance of uncertainty: Behavioural Experiments for Intolerance of Uncertainty or BE-IU. The goal of the current proposal is to test the efficacy of BE-IU (6 weekly treatment sessions) by comparing it to a Waiting List (WL) control condition (6 weeks). A total of 50 participants with a primary diagnosis of GAD will be randomly assigned to either BE-IU or WL and will be assessed at 4 time points ranging from pre-treatment to 12-month follow-up. The conditions will be compared in terms of treatment efficacy and mechanisms. The investigators will also examine the predictors of change during the 12-months following treatment. The proposed study will produce data on the efficacy and mechanisms of a treatment for GAD that is less costly, less complex and easier to disseminate than treatments that are currently available.


Eligibility Criteria:
Inclusion Criteria:

1. at least 18 years of age;
2. principal diagnosis of GAD;
3. no change in medication type or dose in 4 to 12 weeks before study entry (4 weeks for benzodiazepines, 12 weeks for antidepressants and hypnotics);
4. willingness to keep medication status stable while participating in the study;
5. no use of herbal products known to have CNS effects in the 2 weeks before study entry;
6. no evidence of suicidal intent (based on clinical judgement);
7. no evidence of current substance abuse, current or past schizophrenia, bipolar disorder or organic mental disorder;
8. no current participation in other trials;
9. no concurrent psychotherapy during treatment phase of trial;
10. no evidence of anxiety symptoms due to a general medical condition based on clinical judgement (e.g., clinical hyperthyroidism, hypoglycaemia, anaemia).

Exclusion Criteria:

-
Flexible Reinforced Laryngeal Mask Airway Versus Endotracheal Tube for Childhood Adenotonsillectomy

The goal of this clinical trial is to compare the airway management effects of flexible reinforced laryngeal mask and endotracheal tube in childhood adenotonsillectomy.

Participants will be randomly allocated to two groups: endotracheal tube group (ETT) and flexible reinforced laryngeal mask group (FLMA). For those in ETT group: they will be intubated after induction of anesthesia .For those in FLMA group: they will be put in flexible reinforced laryngeal mask after induction of anesthesia .

The investigators will compare FLMA with ETT to see if flexible reinforced laryngeal mask can be used safely and effectively in childhood adenotonsillectomy，and if there will be less severe adverse events in FLMA.


Eligibility Criteria:
Inclusion Criteria:

* patients who choose to have adenotonsillectomy surgery
* the American Society of Anesthesiologists (ASA) physical status ranked I-II
* the oropharyngeal anatomy is normal
* competent to provide informed consent

Exclusion Criteria:

* upper respiratory tract infection one week before surgery
* oropharyngeal anatomy is abnormal
* high risk of reflux aspiration
* liver or kidney failure
* psychiatric disorders
Phase I/Ib Study of GWN323 Alone and in Combination With PDR001 in Patients With Advanced Malignancies and Lymphomas

The purpose of this trial is to explore the clinical utility of two investigational antibodies in patients with advanced cancer or lymphomas.

This is a multi-center, open-label Phase I/Ib study. The study consists of two dose escalation parts and two dose expansion parts testing GWN323 as a single agent or GWN323 in combination with PDR001. The dose escalation parts will estimate the MTD and/or RDE and test different dosing schedules.

The dose expansion parts of the study will use the MTD/RDE determined in the dose escalation part to assess the activity, safety and tolerability of the investigational products in patients with specific types of cancer and lymphomas.

Approximately 264 adult patients with advanced solid tumors or lymphomas will be enrolled.


Eligibility Criteria:
Inclusion Criteria:

* Patients with metastatic and/or advanced solid tumors or lymphomas not amenable to curative treatment by surgery.
* Histologically documented advanced or metastatic solid tumors or lymphomas
* Must have a site of disease amenable to biopsy, and be a candidate for tumor biopsy according to the treating institution's guidelines. Patient must be willing to undergo a new tumor biopsy at screening
* ECOG Performance Status ≤ 2.

Exclusion Criteria:

* Presence of symptomatic central nervous system (CNS) metastases, or CNS metastases that require local CNS-directed therapy (such as radiotherapy or surgery).
* Patients diagnosed with T-cell Lymphomas.
* Patients with prior allogenic transplants.
* Patients previously treated with anti-GITR therapy.
* History of severe hypersensitivity reactions to other mAbs.
* Patients intolerant to prior immunotherapy (unable to continue/receive due to immune-related AE).

Other protocol-defined inclusion/exclusion criteria may apply.
Performance Evaluation of OCT and OCT Angiography-based Ocular Measurements (Optical Coherence Tomography)

The purpose of this study is to assess performance of measurements of anatomical and vascular structures of the eye based on OCT and OCTA scans in normal subjects and eyes with pathology.


Eligibility Criteria:
Inclusion Criteria:

* Normal - No pre-existing conditions.
* Glaucoma - Diagnosis of glaucoma.
* Retina - Diagnosis of retinal pathology
* Cornea - Diagnosis of clinic condition.

Exclusion Criteria:

- Unable to complete required exams.
Efficacy and Safety of Asenapine With Placebo and Olanzapine (41021)(P05933)

Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguish reality from fantasy i.e., hearing voices) and Negative symptoms (a reduction or absence of normal behaviors or emotions, i.e., unable to manage emotions, make decisions and relate to others). Other symptoms include reduced ability to recall and learn new information, difficulty with problem solving, or maintaining productive employment. The symptoms of schizophrenia may be due to an imbalance in chemicals in the brain, primarily dopamine and serotonin, which enables brain cells to communicate with each other.

Asenapine is an investigational drug that may help to correct the imbalance in dopamine and serotonin. This is a 6 week study to test the efficacy and safety of asenapine and a comparator agent (olanzapine) in the treatment of patients with schizophrenia. Patients that complete this trial will have the option of continuing in an additional one year extension trial.


Eligibility Criteria:
Inclusion Criteria:

* Currently suffering from an acute exacerbation of schizophrenia. Caregiver required.

Exclusion Criteria:

* Have an uncontrolled, unstable medical condition. Have any other psychiatric disorder other than schizophrenia as a primary diagnosis.
Effects of Romantic Affection on Blood Chemistry and Immune Parameters

This trial tests the hypothesis that increasing nonverbal affection in romantic relationships will improve blood lipid parameters (total cholesterol, high and low density lipoproteins, triglycerides), blood glucose, and immune parameters (C-reactive protein and antibodies to latent Epstein-Barr virus). 52 healthy cohabiting romantic couples took part. In half of the couples, one partner increased the frequency of romantic kissing with the other partner during the six-week trial. The other couples received no such instruction. Blood tests performed before and after the trial were used to assess the health outcomes.


Eligibility Criteria:
Inclusion Criteria:

* 18+ years of age;
* English-speaking;
* Current co-habitation with romantic partner

Exclusion Criteria:

* History of hypercholesterolemia;
* Current pregnancy;
* Current use of blood-thinning agents;
* Greater than moderate anxiety about giving capillary blood;
* Weight of less than 110 pounds
Home-Initiated Programme to Prepare for Operation (HIPPO) Study

A hospital admission and surgical operation commonly triggers great fear and anxiety to young children. This is caused by either lack of knowledge or misconception. Although parent and families are often given the task to prepare the child for the oncoming surgery, they often lack information and skill to accomplish this task. Although numerous measures such as pre-operative play room, parental companion during induction, distraction therapy have been employed in our institution, this remains to be a challenge for care of young surgical patients.

Our study proposes to use a "prepare-for-operation" (PFO) bundle to assist our paediatric patients and their families to prepare for surgery. The PFO bundle consists of an informative cartoon video illustrating sequence of events occurring in admission, anesthesia and surgery. The video is also accompanied by activity sheets to encourage patient and family to engage, participate and learn about all these events. They will be instructed to use this PFO bundle before admission. We believe that through this off-site and cost-effective intervention, the fear of children undergoing surgery will be significantly alleviated. The family will also have better satisfaction on hospitalization experience. If proven feasible and effective, this will be a simple intervention tool that can be made accessible to all KKH pediatric patients.

Research Plan: A prospective assessor-blinded randomized controlled which will recruit 130 pediatric surgical patients aged 4-10 years, undergoing elective operation in KKH. Eligible patients will be identified when an operation date has been booked. They will be approached by a research coordinator (RC) who will counsel about the study details, and recruited after consent.

Randomisaiton will be performed. The subjects will be randomised into group A and group B.

Group A will undergo standard workflow for elective surgical admissions.

Group B, in addition to standard workflow, will also receive the PFO bundle which consists of:

A cartoon video of about 6 minutes duration illustrating the events occuring during admission, anaesthesia and surgery. Video will be given out in DVD and/or with a weblink and a QR code for scanning. The weblink is password protected and is only given to participant and their parents randomised into the video group. Instruction will be given to participants and their parents to watch the video 3 days prior to admission

Sets of activity sheets which have been tailored for different age groups. Families would be encouraged to complete activity sheets together.

Eligibility Criteria:
Inclusion Criteria:

1. Aged 4-10 years, male or female
2. No prior surgical experience
3. Able to communicate clearly, navigate simple technical software, be awake and alert
4. Normal development
5. Able to read and communicate in English

Exclusion Criteria:

1. Abnormal development
2. Has had prior surgical experience
3. Is participating in another study
Intracoronary Administration of Levosimendan in Cardiac Surgery Patients

Incomplete recovery from ischemia causes stunned myocardium. Ischemia may be due to coronary artery disease or aortic cross-clamping during surgery. Stunning leads to myocardial dysfunction. It has been suggested that the mechanism responsible for the contractile depression in stunned myocardium is a decreased sensitivity of the myofibrils to calcium. Levosimendan is a calcium sensitizer, which has been shown to improve the function of stunned myocardium without obvious impairment of diastolic function. Systemic vasodilation and need of vasoconstrictive medication is usually apparent after administration of levosimendan. Colucci et al have demonstrated that with intracoronary administration of milrinone, another inodilator, systemic vasodilation could be excluded. If this is true with levosimendan, it may be possible to improve left ventricular hypo/dyskinesia without afterload reduction by adding levosimendan into cardioplegia solution.

The investigators hypotize that levosimendan, delivered together with cardioplegia, can improve LV dysfunction after opening of aortic cross-clamp in patients undergoing aortic valve and coronary artery bypass operation. Our primary endpoint is a change in cardiac output 15 min after separation from cardiopulmonary bypass compared to the baseline. Secondary endpoints are a change in LV ejection fraction from baseline to 5 min after sternal closure and cTnT/CK-MB on the first postoperative morning.


Eligibility Criteria:
Inclusion Criteria:

* preoperative LVEF 40% or less
* septal wall thickness more than 11mm
* less than moderate aortic insufficiency
* sinus rhythm before CPB

Exclusion Criteria:

* oesophageal disease
* known allergy to levosimendan or its metabolites or adjuvants.
Interest of a Highly Cross-linked Polyethylene Acetabular Component Doped With Vitamin E in Total Hip Arthroplasty of the Young and Active Subject

Interest of a highly cross-linked polyethylene acetabular component doped with vitamin E in total hip arthroplasty of the young and active subject.

A single-centre, prospective, randomised, single-blind, comparative study of two parallel groups of patients undergoing total hip arthroplasty:

* Group 1: Prosthesis with a second-generation ceramic-on-highly cross-linked polyethylene (CoPXE) couple.
* Group 2: Prosthesis with ceramic-on-ceramic (CoC) torque.

Eligibility Criteria:
Inclusion Criteria:

* Patient aged 18 to 65 years,
* Who have signed their consent to participate in the study,
* For whom an indication for total hip arthroplasty has been given

Exclusion Criteria:

* History of hip surgery
* Indication for a dual mobility prosthesis (obese patient, dynamic spino-pelvic anomaly)
* Hip dysplasia
* Inflammatory rheumatic disease or any other progressive concomitant condition that may impact the patient's vital or functional prognosis
* Sequelae of neurological disease or stroke
* Pregnant or breastfeeding women
* Mental deficiency or any other reason that may hinder the understanding or the strict application of the protocol
* Patient likely not to return for follow-up visits
* Patient already included in another therapeutic study protocol
* Patient under court protection, guardianship or curatorship.
Effect of Doula in Nulliparas and Multiparas

Psychological care during labor is considered as an important supplemental procedure for alleviating delivering stress and pain. Although Doula has been recommending that should be given for parturients, its precise effect on nulliparous and multiparous women is still unknown. The investigators hypothesized that multiparas had experienced the process of labor, but the nulliparas were not, so Doula support would produce different effect on these two population.


Eligibility Criteria:
Inclusion Criteria:

* Healthy term parturients
* Chinese
* 19-45 years

Exclusion Criteria:

* Organic dysfunction
* Participants younger than 19 years or older than 45 years
* Those who were not willing to or could not finish the whole study at any time
* Pregnancy-induced hypertension and diabetes mellitus
Optimizing Pre-Exposure Prophylaxis (PrEP) Among Latino Men Who Have Sex With Men (MSM) in Puerto Rico

To develop, assess and compare the effectiveness of a Motivational Interviewing Intervention for increasing Pre-Exposure Prophylaxis (PrEP) uptake among Latino Men Who Have Sex With Men (MSM) in Puerto Rico.


Eligibility Criteria:
Latino MSM group - Inclusion Criteria:

* Biological male
* Age 21 or older
* Self-reported HIV negative or unknown status
* Not using PrEP (participants who have discontinued PrEP use can participate in the study), Spanish fluency (ability to write and read in Spanish)
* Presenting at least one of the eligibility criteria for PrEP as established by the CDC (including men who have had an infection (STI) in the past 6 months, HIV positive sexual partner)
* Access to a portable technology device (e.g., phone, tablet, laptop) or desktop computer access to internet connection

Exclusion Criteria:

* HIV positive individual
* Evidence of being under the effects of alcohol or drugs
* Indication of unstable or serious psychiatric symptoms
* Evidence of major cognitive impairment
* Inability to speak and read in Spanish

Healthcare Providers group - Inclusion Criteria:

* Age 21 or older
* Providing PrEP related health services at time of enrollment (e.g., case management, clinical services)
* Spanish fluency (ability to write and read in Spanish)

Exclusion Criteria:

* Evidence of being under the effects of alcohol or drugs
* Indication of unstable or serious psychiatric symptoms
* Evidence of major cognitive impairment
* Inability to speak and read in Spanish