cyrilzakka/clinical-trials huggingface dataset:
Effect of Certain Breakfasts on Appetite Control

This clinical trial is being conducted to study whether eating certain meals will reduce your desire to eat and for a longer period of time compared to others and to determine the post-meal glucose response associated with each of these breakfast foods.

The study is divided into 3 phases. Each phase involves eating one of 3 different breakfasts every day for 1 month. The order of the breakfast products is random. During each phase participants will come to the research clinic for 4 visits (1 per week) for assessment of appetite-related sensations. Gastric emptying will be assessed at 1 visit per phase and post prandial glucose response will be measured at 1 visit per phase (Asper site only).

Eligibility Criteria:
Inclusion Criteria:

1. Healthy Males and females (not pregnant or lactating) aged 19 to 60 years.
2. Body mass index: 18.5-30 kg/m2.

Exclusion Criteria:

1. A change in medication (dose or type) or medical event requiring hospitalization within the past month.
2. Daily tobacco use.
3. Physical Activity Level \>1.8.
4. Eat meals at irregular or unusual times.
5. Food allergy, aversion or unwillingness to eat study foods.
6. Use of any prescription or non-prescription drug, herbal or nutritional supplement known to affect appetite or blood sugar.
7. Presence of a gastrointestinal disorder.
8. Taking drugs that affect gastric emptying.
9. Score \>65% on any 1 of the 3 categories of the Three Factor Eating Questionnaire-R18.
Spatio-temporal Parameters of Walking in Patients Hospitalized in Acute Geriatrics

The prevalence of walking disorders in the elderly is high. These can lead to falls which represent a major public health issue in terms of hospitalization, morbidity and cost. Numerous studies analyzing the link between spatio-temporal parameters of gait and fall have already been carried out, but most have been carried out in a population of elderly patients living at home and having no or few comorbidities. Very few studies have been carried out in a population of frail elderly people, with multiple comorbidities or multiple medication, which is the case with most patients hospitalized in acute geriatrics.

The objective of the study is to evaluate the spatio-temporal parameters of walking using the GAITRite® mat in patients hospitalized in acute geriatrics and to compare them between a population of falling patients and a population of patients. no faller.


Eligibility Criteria:
Inclusion criteria:

* Subject aged \> 70 years
* Have been hospitalized in an acute geriatric ward at the University Hospitals of Strasbourg between 01/06/2019 and 28/02/2020
* Have been able to walk on a square surface at least 12 meters long, with or without technical assistance
* Subject not having expressed, after being informed, his opposition to the reuse of his medical data for scientific research purposes.

Exclusion criteria:

* Subject having expressed opposition to participating in the study
* Non-autonomous subject for transfers and trips
* Subject under guardianship, curatorship or safeguard of justice
Cervical Cancer Screening by Self-sampling in a Cohort of Younger Women in Ethiopia

The overall purpose of the project is to evaluate an algorithm for an HPV self-sampling based cervical cancer screening algorithm in a mid-size town in Ethiopia that could be applicable for nationwide implementation in low and middle-income countries (LMIC).

Specific aims are the following:

* To evaluate the algorithm using Visual Inspection with Acetic acid (VIA) and VIA together with Lugol's Iodine (VILI) as triage and to use HPV self-sample to follow up those treated and those with persisting HPV.
* To evaluate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and other STIs in the cohort.
* To determine immune response profiles in high-risk HPV-positive women who cleared, persisted, or developed Cervical Intraepithelial Neoplasia 2/3 (CIN).
* To assess how specific cervicovaginal microbiota compositions are associated with HPV infection, cervical dysplasia, and cancer


Eligibility Criteria:
Inclusion Criteria:

* Can give consent, Age above 18

Exclusion Criteria:

* Women who have undergone hysterectomy
Effects of Platelet Rich Plasma on Endometrium

Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period. The endometrial thickness will be assessed under ultrasound and hormone replacement will be started. As the endometrial thickness reaches adequate thickness during ultrasound follow-up, embryo transfer will be performed.

Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period. In the second menstrual period following the PRP injection, the endometrial thickness will be assessed under ultrasound and hormone replacement will be started. As the endometrial thickness reaches adequate thickness during ultrasound follow-up, embryo transfer will be performed. Pregnancy test results will be recorded and followed.

Eligibility Criteria:
Inclusion Criteria:

* Women in whom cycle was cancelled due to an endometrial thickness \<7 mm when progesterone start was planned in patients undergoing frozen embryo transfer with hormone replacement therapy
* Women with a history of Asherman syndrome, but no obvious intrauterine adhesion in the last hysteroscopic procedure;
* Women who have at least 2 frozen good-quality embryos.

Exclusion Criteria:

* Women with any other known cause of implantation failure, such as poor embryo quality, or congenital uterine anomalies, endometrial polyp or fibroid,
* Previous diagnosis of any malignancy,
* Anticoagulant use for which plasma infusion is contraindicated,
Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy

Randomized controlled trial (1:1) in two parallel groups, multicentric, open-label, comparing two locoregional anesthesia (LRA) techniques as integral parts of multimodal analgesia: the control group will benefit from epidural anesthesia, while the experimental group will benefit from bilateral placement of catheters in the sheath of the rectus abdominis muscles.

Implementation of fast-track rehabilitation surgery was essential in patient care, specially in oncological point.

In this way, uses of the technic of local anesthesia, include epidural analgesia, was essential, but this one is associated with few complications. Emergence of new technic of anesthesia with a comparative analgesia and without side effects should be a better alternative than epidural analgesia. Thus, bilateral rectus sheath block has been reported to be effective in management of postoperative pain.

After signing of the informed consent, two postoperative analgesia techniques were investigated in patients undergoing midline laparotomy.

The main objective of this study is to compare the influence of analgesic technique on the Quality of Recovery-15 score. The study design was a prospective, randomized trial with 2 parallel arms (epidural analgesia vs bilateral rectus sheath block).

Eligibility Criteria:
Inclusion Criteria:

* ASA (American Society of Anesthesiologists) Class I-IV adult, with programmed midline laparotomy
* Have given an informed written consent
* Able to read and understand french language
* Affiliation to a social security system

Exclusion Criteria:

* Local anesthesic contraindication (allergy, porphyria, haemolytic anaemia, uncontrolled epilepsy, or severe cardiac conduction disorders) or TEA (coagulation disorders, progressive neurological disease, or severe spinal disorder),
* Epidural analgesia contraindication
* With impossibility to set up bilateral rectus sheath block
* Participation in another clinical study
* Pregnant women
* Patients deprived of their liberty by a judicial or administrative decision,
* Patients undergoing psychiatric care under articles L.3212-1 and L.3213-1 of the French Public Health Code
Sepsis Assessment in Belgian Emergency Rooms

To validate the use of the Heparin Binding Protein (HBP) concentration to assist in the evaluation of patients admitting to the emergency department with suspected infection.

Prospective, non-interventional, multi-centre clinical study to assess the clinical validity of the Heparin Binding Protein (HBP) assay to assist in evaluation of patients with suspected infection following emergency department admission.

Patients presenting to the emergency department with suspected infection will be enrolled to the study and have a blood sample taken.

The patients clinical data over a 72 hour period after enrolment will be recorded in the CRF. The enrolment sample will then be retrospectively measured for the HBP level and the power of the enrolment HBP level to predict subsequent clinical development over the following 72 hours will be assessed. Data analysis shall include Area Under Curve (AUC) from Receiver Operating Characteristics (ROC) plot against the patient's final clinical diagnosis as well as sensitivity and specificity of the HBP level to predict the final clinical outcome.

Eligibility Criteria:
Inclusion Criteria:

* \>18 years of age,
* Suspected infection (temperature \>38C or clinical evidence of infection),
* intention by clinician to start antibiotics

Exclusion Criteria:

* None
Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds.

Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.


Eligibility Criteria:
Inclusion Criteria:

* Subjects \> 65 years of age diagnosed with RSV-induced respiratory illness
* Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
* Willing to sign informed consent.

Exclusion Criteria:

* Not willing to sign informed consent.
* Subjects less that 65 years of age
* Subjects not diagnosed with a respiratory illness
Effect of Anti-aging Therapy on Fitness Enhancement in Perimenopausal Women

Aging is an important fact to consider from the woman's health perspective. One of the most significant stages of aging is menopause, in which involves physical, psychological, and social changes in life

This study will be carried on forty perimenopausal women. They were selected randomly from outpatient clinic of El Kaser El-Einy University Hospital, Cairo University, their age ranged from 40 to 50 years.

Group A ( Control group):

It consisted of 20 perimenopausal women. They received anti-aging diet instructions.

Group B ( Experimental group):

It will be consisted of 20 perimenopausal women.They received anti-aging therapy (Aerobic, Flexibility and strengthening exercises) with anti aging diet instructions.

Randomization:

Randomization of sample selection was achieved using closed envelop way. Classification of the sample by simple random way into two groups equal in number, twenty for each group by using forty closed envelop, each twenty envelop contained a name of a group from the two groups (Group A) or (Group B) and asking each woman to choose one envelop from them, each woman attended to the group according the name of the group written in her envelop.

Eligibility Criteria:
Inclusion Criteria:

* They complaining from fatigue, hot flushes and irregular period.
* Their Body Mass Index (BMI) between 25 to 30 .
* Their age ranged from 40 to 50 years old.
* The assessment procedures will be conducted on the same time of the day pre/post treatment.

Exclusion Criteria:

* Women with comorbidities such as cardiac disease and chest diseases as pulmonary fibrosis.
* Women received medications that might affect the neuromuscular functions at least three months before or during the study course.
* Women suffered from mental or psychological disorders.
* Women suffered from inflammatory diseases such as rheumatoid arthritis or polymyalgia rheumatic.
* Women complaining from osteoporosis.
Deficit Fields for Stroke Recovery

This study investigates the potential of customized robotic and visual feedback interaction to improve recovery of movements in stroke survivors. While therapists widely recognize that customization is critical to recovery, little is understood about how take advantage of statistical analysis tools to aid in the process of designing individualized training. Our approach first creates a model of a person's own unique movement deficits, and then creates a practice environment to correct these problems. Experiments will determine how the deficit-field approach can improve (1) reaching accuracy, (2) range of motion, and (3) activities of daily living. The findings will not only shed light on how to improve therapy for stroke survivors, it will test hypotheses about fundamental processes of practice and learning. This study will help us move closer to our long-term goal of clinically effective treatments using interactive devices.


Eligibility Criteria:
Inclusion Criteria:

STROKE SURVIVORS:

* adult (age \>18)
* Chronic stage stroke recovery (8+ months post)
* available medical records and radiographic information about lesion locations
* strokes caused by an ischemic infarct in the middle cerebral artery
* primary motor cortex involvement
* a Fugl-Meyer score (between 15-50) to evaluate arm motor impairment level

HEALTHY CONTROL PARTICIPANTS:

* adult (age \>18)
* healthy individuals with no history of stroke or neural injury

Exclusion Criteria:

* bilateral paresis;
* severe sensory deficits in the limb
* severe spasticity (Modified Ashworth of 4) preventing movement
* aphasia, cognitive impairment or affective dysfunction that would influence the ability to perform the experiment
* inability to provide an informed consent
* severe current medical problems
* diffuse/multiple lesion sites or multiple stroke events
* hemispatial neglect or visual field cut that would prevent subjects from seeing the targets.
Comparison of the Effects of Different PEEP Values With USG on Optic Nerve Sheath Diameter

Laparoscopic surgeries are now more popular because of the advantages such as shorter hospital stay, minimal scar. In order to perform laparoscopic surgery, pneumoperitoneum should be initiated. The optic nerve sheath is an extension of the dura mater and the subarachnoid space is continuous with the intracranial subarachnoid space. Therefore, non-invasive monitoring of the increase in intracranial pressure (ICP) can be achieved by measuring the optic nerve and sheath diameter with ultrasound. Since ONSD measurement with ultrasound is an easily applicable technique, it is useful in monitoring intracranial pressure changes based on the optic nerve diameter during intraoperative changes

Laparoscopic surgeries are now becoming increasingly common compared to traditional laparotomies, as they have advantages such as more minimal scarring, shorter hospital stay, fewer complications, and early mobilization. In these surgeries, pneumoperitoneum provided with carbon dioxide (CO2) has many effects on the cardiovascular, pulmonary, renal, metabolic and cerebral systems. Pulmonary compliance and functional residual capacity decrease due to pnemoperitoneum, ventilation/perfusion mismatch occurs, and as a result, hypoxemia may occur. A minimum of 4-6 cm H20 positive end-expiratory pressure (PEEP) should be applied to all intubated patients under general anesthesia to reduce postoperative pulmonary complications (especially atelectasis) and prevent ventilation/perfusion mismatch and hypoxemia. The optic nerve sheath is an extension of the dura mater and the subarachnoid space is continuous with the intracranial subarachnoid space. Therefore, non-invasive monitoring of the increase in intracranial pressure (ICP) can be achieved by measuring the optic nerve and sheath diameter with ultrasound. When ICP is \> 20 mm Hg, measuring the optic nerve sheath diameter (ONSD) between 5.2 and 5.9 mm has a sensitivity of 74-95% and a specificity of 74-100%. Since ONSD measurement with ultrasound is an easily applicable technique, it is useful in monitoring intracranial pressure changes based on the optic nerve diameter during intraoperative changes (trendelenburg/reverse trendelenburg position, pneumoperitoneum , PEEP in mechanical ventilation).

Eligibility Criteria:
Inclusion Criteria:

* 18- 65 aged all female and male volunteers

Exclusion Criteria:

* acute or chronic eye diseases,
* uncontrolled hypertension,
* asthma
* known lung disease,
* body mass index (BMI) over 35 kg/m2,
* devices using bulbs with known intracranial charging,
* who refuse to participate in care
Dynamic Substrate Mapping (DSM) for Ischemic VT

This is a prospective, non-randomized study to determine the feasibility of using a new technique called Dynamic Substrate Mapping (DSM) to help guide the treatment of ischemic ventricular tachycardia (IVT). We hypothesize that DSM will lead to simpler, more effective ablation of IVT. Results from this study will be used to determine if further clinical investigation is warranted.


Eligibility Criteria:
Inclusion Criteria:

* Have an ICD or CRT-D device
* Had at least 3 documented device therapies to treat VT over last 3 months
* Clinical VT is confirmed or suspected to be of ischemic origin
* Scheduled for VT ablation procedure
* LVEF \> or = 20%

Exclusion Criteria:

* Inadequate AAD washout (amiodarone should be maintained at current dose)
* Unstable angina
* Active ischemia
* Cardiac surgery within prior 2 months
* Evidence of infection
* Prosthetic mitral or aortic valve or mitral/aortic valvular heart disease requiring surgical intervention
* History of embolic event
* Myocardial infarction within prior 6 weeks
* Enrolled in another study
* Recurrent sepsis or otherwise not a candidate for catheterization
* Hypercoagulable state or inability to tolerate heparin therapy during procedure
* Has had an atriotomy or ventriculotomy within prior 4 months
* Life expectancy \< 6 months
* Class IV NYHA classification
Characteristics of Critically Ill COVID 19 Patients

COVID19 is n outbreak with unpredictable outcome


Eligibility Criteria:
Inclusion Criteria:

* COVID 19 patients need oxygen therapy

Exclusion Criteria:

* patients does not need oxygen therapy
Incidence of Expression of Tumor Antigens in Cancer Tissue From Patients With Pathologically Demonstrated Bladder Cancer

This study aims to analyze the incidence of expression of MAGE-A3, MAGE-C2, NY-ESO-1, LAGE-1, WT1 and PRAME tumor antigens in cancer tissue from patients with pathologically demonstrated bladder cancer.

There will be no procedure(s) or treatment(s) carried out on patients. All data and samples will be taken from those already stored at the investigation sites. Clinical data collected will include patient demographics (age, gender), Tumor, Node, Metastasis (staging system) \[TNM stage\], and histopathologic description only. Strict anonymity of patient data will be maintained.

This retrospective study is based upon the analysis of archived formalin-fixed paraffin-embedded tissue samples and patient-related data already available at the investigational site.

Eligibility Criteria:
Inclusion Criteria:

For inclusion of a tissue sample, all of the following criteria must be met:

* The patient had pathologically proven bladder cancer (any stage).
* All the data required are available from patient's records.

There are no restrictions regarding operative technique (cystectomy or cystoscopy).

- Many patients may no longer be alive, or no longer be in contact with the investigation sites. Thus, patients will not be required to give their informed consent before inclusion in the study.

Exclusion Criteria:

* Not applicable.
Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake

The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger \& satiety.

The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.

Eligibility Criteria:
Inclusion Criteria:

* male
* healthy
* non-smoking
* normal taste responses towards sweet taste

Exclusion Criteria:

* female
* regular smokers
* disturbed glucose and/or lipid metabolism
* regular intake of medication
* known allergies against one of the test compounds
* ageusia
* alcohol or drug addiction
* intake of antibiotics within the past 2 months
Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine

The purpose of this study is to investigate the effect of different 6% hydroxyethyl starch (130/0.4) coload volumes on the 90% effective dose of norepinephrine infusion prophylaxis for hypotension during spinal anesthesia for cesarean section.

Post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. The incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. Coload has been highly demonstrated for prevention and/or treatment of post-spinal anesthesia hypotension. In addition, there's some evidence that prophylactic infusion of norepinephrine could effectively reduce the incidence of post-spinal anesthesia hypotension in parturients undergoing cesarean section. The purpose of this study is to investigate the effect of different 6% hydroxyethyl starch (130/0.4) coload volumes on the 90% effective dose of norepinephrine infusion prophylaxis for hypotension during spinal anesthesia for cesarean section.

Eligibility Criteria:
Inclusion Criteria:

* 18-45 years
* Primipara or multipara
* Singleton pregnancy ≥37 weeks
* American Society of Anesthesiologists physical status classification I to II
* Scheduled for cesarean section under spinal anesthesia

Exclusion Criteria:

* Body height \< 150 cm
* Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
* Eclampsia or chronic hypertension or baseline blood pressure ≥180 mmHg
* Hemoglobin \< 7g/dl
* Fetal distress, or known fetal developmental anomaly