cyrilzakka/clinical-trials huggingface dataset:
In This Study, the Sponsor Would Like to Collaborate with Institution and Investigator to Aggregate Participants Data and to Pilot Its Software Algorithm Using Machine Learning and Threshold Based Methods for Predicting Exacerbations and Deterioration Within a 60 Days Period Post-discharge

In this study, the sponsor would like to collaborate with Institution and Investigator to aggregate participants data and to pilot its software algorithm using machine learning and threshold based methods for predicting exacerbations and deterioration within a 60 days period post-discharge.


Eligibility Criteria:
Inclusion Criteria:

1. Subject age 18 or older
2. Receives all primary and specialty care at Institution
3. Participants will be enrolled at discharge (and not designate hospital or ED)
4. A history of one of the following diagnoses:

   a. c. Chronic obstructive pulmonary disease
5. At least two documented exacerbations of the above disease in the past 12 months as defined by the following corresponding criteria:

   a. Chronic obstructive pulmonary disease exacerbation: all three of (1) increase in frequency and severity or severity of cough, (2) increase in volume and/or change of character of sputum production, and (3) increase in dyspnea, and requiring treatment with short-acting bronchodilators, antibiotics, and oral or intravenous glucocorticoids.
6. Participants able to provide informed consent.
7. Participants will be enrolled at discharge (and not designate hospital or ED)

Exclusion Criteria:

1. Participants with neuromuscular diseases and seizures
2. Participants enrolled in hospice care or life expectancy less than three months.
3. Participants living more than 60 miles away from Institution and Investigator
4. Participants with expected out of state travel within a 30-day period or travel to a location with no internet access.
Functional and Clinical Impact of CYP3A Genetic Polymorphisms on Statin Therapy

Patients needing lipid lowering therapy will be recruited before initiation of the treatment. For each patient, total and LDL cholesterol levels before start of therapy will be measured. One, three and six months after his/her first visit, when steady-state will be reached, for each included patient, the cholesterol levels will be re-assessed in order to evaluate the response to statin therapy calculated as the amplitude of cholesterol reduction. The aim is to assess the association between patient's genotype and the response to statin therapy.


Eligibility Criteria:
Inclusion Criteria:

* Patient known to be compliant
* Age \[25-80\]
* treated with Atorvastatin, simvastatin, fluvastatin.

Exclusion Criteria:

* Pregnancy
Correlation of Atrial Fibrillation Recurrence After Bipolar Radiofrequency Ablation With microRNA Expression

The recurrence rate of atrial fibrillation (AF) after bipolar radiofrequency ablation was about 30%. Besides the factors, left atrium diameter, the duration of AF, NT-proBNP, and ejection fraction(EF), some studies demonstrated that the specific microRNA expression (miRNA1, miRNA19,miRNA23, miRNA409 ) showed the significant change in AF patients compared with normal sinus patients, who underwent catheter ablation. Therefore, the correlation of atrial fibrillation recurrence and above-mentioned microRNA after bipolar radiofrequency ablation remained unclear, although bipolar radiofrequency ablation had high rate of sinus.

Numerous studies identify specific microRNA (miRNA) expression profiles associated with atrial fibrillation (AF), changes in plasmamiRNA expression in pre-and post-operativeAFpatients who have received catheterisation . The correlation of atrial fibrillation recurrence and above-mentioned microRNA after bipolar radiofrequency ablation remain poorly characterized.

This study aimed to reveal disease-related biomarkers by detecting plasmamiRNA expression in AF patients, and examining the levels of AF-specific miRNAs in patients after bipolar radiofrequency ablation, in order to help gauge therapeutic effects and assess prognosis.

A total of 50 Han Chinese patients with AF who had received bipolar radiofrequency ablation recruited to the study. Atrial fibrillation-specific plasma miRNAs were detected by sequencing and quantitative reverse transcription polymerase chain reaction. According to AF recurrence rate of about 30%, the expression levels of AF-specific miRNAs were investigated in15 post-operative AF patients and 35 patients with normal sinus after ablation,to explore changes in miRNA expression.

Eligibility Criteria:
Inclusion Criteria:

persistent atrial fibrillation, with alone mitral valve stenosis or regurgitation

Exclusion Criteria:

left atrium more than 60mm ejection fraction less than 30% complicated with other valve disease of aortic valve stenosis or regurgitation
Evaluation of Sedation in COVID-19 ARDS

This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients. The sedation response of \>100 moderately to severely affected COVID-19 ARDS was evaluated. The sedation level was measured at the bedside using the Richmond Agitation and Sedation Scale and ventilator synchrony. The evaluation was performed according to the static evaluation plan with respect to age, storage therapy and organ failure.


Eligibility Criteria:
Inclusion Criteria:

moderate to severe COVID-19 ARDS

Exclusion Criteria:

None
Patient Perspectives on Artificial Intelligence in Radiology

The investigators will conduct a short questionnaire with patients who are waiting for radiology exams to understand their views on the use of artificial intelligence in radiology. The questionnaire will be anonymised and entirely optional. Results will be published in peer-reviewed publications and inform future implementation of AI in clinical radiology.

The project entails a patient questionnaire. Patients will firstly be informed about the study via a member of the radiology care team. Informed consent will be obtained by a member of the team. Each participant will be assigned a unique identifier number upon recruitment. Aside from the signed consent form, no identifiable information or medical details will be collected. Consent documentation will be stored within a locked drawer in the research department of the radiology department in GSTT. The signed consent document will be kept entirely separate and will not be linked in any way to the questionnaire answers. The questionnaire data will therefore be anonymised data. A document containing the following items will be created on a GSTT computer and updated as the study progresses:

1. Participant Unique Identifier
2. Questionnaire Answers 5.2 Questionnaire When the study identifier number is assigned, it will be entered at the top of a paper questionnaire. The questionnaire is thus anonymised from the beginning of the study. The questionnaire will include demographic variables and questions with multiple choice responses corresponding to a Likert scale, which will be completed by the patient. This information will be transferred to an NHS computer in the radiology department in GSTT.

Survey data will not include identifiable information. A Gaussian Graphical Model will be inferred indicating conditional dependencies between demographic variables and participant responses. This will be performed using the desparsified Graphical LASSO method of Jankova, implemented via the R package SILGGM.

Eligibility Criteria:
Inclusion Criteria:

1. Patients presenting to the radiology department waiting area for an elective appointment will be eligible to participate.
2. Participants must be aged above 18 years.
3. Participants must have independent capacity to consent to the study.

Exclusion Criteria:

1. Inpatients or acute patients presenting to the radiology department waiting area.
2. Those who cannot complete informed consent.
Diet Versus Control Pregnant Barbadian Women Gestational Weight Gain Trial

The researcher will study a group of pregnant Barbadians with BMI at booking of greater than or equal to 35. All of the women will be given leaflets telling them about healthy diets in pregnancy and how to limit weight gain. Half of the women will be sent to the dietitian for small group classes on diet and how to limit weight gain. The two groups of women will be compared to see which group gains more weight and which group has more complications during the pregnancy.

More than 2100 pregnant women per annum deliver their babies at the Queen Elizabeth Hospital, the lone publicly-funded hospital providing secondary and tertiary-level obstetric care in Barbados. Routinely recorded data do not capture whether patients are overweight or obese. Thus, the prevalence of obesity is not known amongst this population. Additionally, these women are not routinely referred for dietician services, and thus the impact of dietician intervention is not known. The aim of this research is to determine whether a dietitian-led intervention could lead to decreased gestational weight gain and less incidence of foetal macrosomia in a sample of Barbadian women, with class II obesity, attending a public antenatal clinic. Prior studies examining gestational weight gain, found no statistically significance between groups when a BMI of 30 was used. It is hoped that by using a group with higher obesity a larger difference will be seen with the intervention. Participants with body mass index greater than 35kg/m\^2 who meet the eligibility criteria will be selected from one of five antenatal clinics at the Queen Elizabeth Hospital on the island of Barbados. They will be randomised to either receive didactic dietary sessions or a standard education tool. Mean weight change will be compared amongst the two groups after delivery to determine if there was a decrease in gestational weight gain amongst the intervention group.

Eligibility Criteria:
Inclusion Criteria:

* Woman over 18 years old
* Live singleton pregnancy
* BMI of greater than or equal to 35kg/m\^2
* Registered patient of the Queen Elizabeth Hospital Antenatal Clinic

Exclusion Criteria:

* Presence of gestational diabetes or chronic diabetes mellitus,
* Have had bariatric surgery
* Do not speak english
* Pregnancy with a multiple gestation.
Detection of Adenomas in Screening Colonoscopy

The Endocuff study aims to show an increase of the number of detected adenomas in screening colonoscopies when a endocuff vision (Arc Medical Design Ldt Leeds England) is used.

Endocuff is a relatively new device which is intended to be attached to the end of the colonoscope. Several minor studies have shown that the use of Endocuff probably increases the number of detected polyps in colonoscopy. Endocuff is made of soft plastic and has been designed to give an optimal view of the entire colon. It gently averts and flattens folds in order to see small polyps "hiding" in the space behind colonic folds.

The purpose of this study is to investigate into the effect of the Endocuff in screening colonoscopy compared with screening colonoscopy performed without Endocuff. The device has been used during several years yet an effect on the number of polyps detected during screenings colonoscopy has not been shown. This studies main hypothesis is that the use of Endocuff in screenings colonoscopy will increase the adenoma detection rate in these patients, with a potential to reduce interval cancer.

This study is a randomized controlled trial with 900 patients.

Eligibility Criteria:
Inclusion Criteria:

* all Citizens participating in the national bowel screening program

Exclusion Criteria:

* persons who are disabled and who do not understand the Danish language
* persons treated with Marcoumar, Marevan, Eliquis, Pradaxa e.g. and who are not eligible to polyp resection
* persons who due to diseases of the eyes or Heart are not allowed to receive Buscopan.
* persons with active colitis/diverticulitis, colon stenosis e.g. due to cancer, where a complete colonoscopy is not possible to achieve
Communication Competence and Transdisciplinary Cooperation in Geriatric Nursing

The ability to communicate and cooperate effectively is essential in geriatric nursing. However, nursing teachers lacked the exploration of the development of this ability and teaching evaluation in previous studies. The investigators used a systematic process to investigate methods for achieving the following goals: 1. Cultivate a positive attitude toward the elderly among nursing students. 2. Improve nursing students' communication competence and interaction skills when providing advanced health care services. 3. Improve the teaching skills of professional nursing instructors.

The ability to communicate and cooperate effectively is essential in geriatric nursing. However, nursing teachers lacked the exploration of the development of this ability and teaching evaluation in previous studies. The investigators used a systematic process to investigate methods for achieving the following goals: 1. Cultivate a positive attitude toward the elderly among nursing students. 2. Improve nursing students' communication competence and interaction skills when providing advanced health care services. 3. Improve the teaching skills of professional nursing instructors.

Using an action research approach, the investigators designed a pair of geriatric nursing and practicum courses and recruited a class of in-service nursing students through convenience sampling in a college setting. The intervention was an 18-week course in geriatric nursing that meets once a week in the classroom and internship practice in settings used for training nursing students. The investigators collected using quantitative indicators (attitude measurements) and qualitative textual analysis. The quantitative data were analyzed by paired t-testing using SPSS 21.0 software.

Eligibility Criteria:
Inclusion Criteria:

* The research object of this project will be the students in the nursing class of a university (third year students), and the students who have taken 2 credits each of "Geriatric Nursing" and "Geriatric Nursing Internship" in a working class.

Exclusion Criteria:

* Not a junior in a working class in a university nursing department.Those who have not completed the courses of "Geriatric Nursing" and "Geriatric Nursing Internship".
Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain

Conducted by Binh Luu Thi, Lan Tran Thi, and Minh Hang Hoang Thi at Thai Nguyen National Hospital, the study investigates a new approach to treating persistent collateral ligament pain, common among athletes. The research examines the therapeutic use of hydrolyzed collagen peptide injections, a treatment that addresses pain and inflammation in ways previous methods have not.

The study involves a randomized controlled trial with 62 patients, all diagnosed with inflammation in the collateral ligament site. The patients are split into two groups: one receiving collagen injections alongside oral painkillers and the other receiving depo-medrol injections with oral painkillers.


Eligibility Criteria:
Inclusion Criteria:

* age above 18 years,
* lateral knee pain with a duration of 3 months or longer,
* ultrasound evidence of inflammation of the femoral condyle attachment point,
* agreement to participate in the study

Exclusion Criteria:

* trauma,
* infection,
* dermatitis at the site of the inflammation,
* damage to surrounding knee structures,
* history of chronic inflammatory arthritis (such as gout or rheumatoid arthritis),
* local corticosteroid injection within 3 months before participating in the study.
Omega-3 Supplementation to ADHD Medication in Children

This study is a 12-week open-label trial to assess the effectiveness of Omega-3 fatty acids for deficient emotional self-regulation (DESR) as a supplement to Attention Deficit/Hyperactivity Disorder (ADHD) treatment in children and adolescents with Attention Deficit/Hyperactivity Disorder. Subjects will be between the ages of 6-17 and will currently be on medication for their Attention Deficit/Hyperactivity Disorder but still experience DESR traits.


Eligibility Criteria:
Inclusion Criteria:

* Male or female children ages 6-17 years
* Living at home
* A diagnosis of ADHD (inattentive, hyperactive/impulsive, or combined type) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) based on clinical assessment
* Having a score outside the normal (a T-score of 60 or greater) on the Emotional Control subscale of the Behavior Rating Inventory of Executive Function (parent-report version) or a score outside the normal range (cumulative of 180 or greater) on the Anxious/Depressed, Attention Problems, and Aggressive Behavior subscales of the Child Behavior Checklist for ages (6-18)
* Currently on FDA approved traditional stimulant medication (such as Concerta of Adderall XR) or non-stimulant medication (such as Strattera or Tenex) for their ADHD for at least one month
* Beings able to come to weekly/monthly study visits for 12 weeks
* Having a parent or guardian with a level of understanding of the study

Exclusion Criteria:

* Having unstable medical illness as determined by the clinician investigator
* Having a current diagnosis of schizophrenia or bipolar disorder
* Having delusions or hallucinations
* Having a bleeding disorder
* Taking any other ongoing non-ADHD psychotropic medications other than stable, effective serotonin reuptake inhibitors such as fluoxetine (Prozac), citalopram (Celexa) or medications used on an as-needed basis
* Pregnant or nursing females
* IQ \< 70 by previous testing or as judged by the clinician investigator
* Illegal substance use
* Investigator and his/her immediate family; defined as the investigator's spouse, parent, child, grandparent, or grandchild
* Presence of suicidal risk, or homicidality
* Unwilling/unable to comply with study procedures
* Allergies to fish or shellfish or omega 3 fish oils; multiple adverse drug reactions
* Poor command of the English language
Comparison of Dreem to Clinical PSG for Sleep Monitoring in Apnea Patients

This study aims to evaluate the accuracy of apnea detection and automated sleep analysis by the Dreem dry-EEG headband and deep learning algorithm in comparison to the consensus of 5 sleep technologists' manual scoring of a gold-standard clinical polysomnogram (PSG) record in adults during a physician-referred overnight sleep study due to suspicion of sleep-disordered breathing.

The study will enroll up to 70 adults who are referred to the Stanford Sleep Medicine Center by their physician for an overnight polysomnographic sleep study due to suspicion of sleep-disordered breathing, with the aim of collecting 60 usable data sets (i.e., eligible subjects with high-quality PSG and Dreem recordings). Upon arrival to the clinic, patients provide informed consent, are interviewed to determine eligibility, and complete a detailed demographic, medical, health, sleep, and lifestyle questionnaire (Alliance Sleep Questionnaire; ASQ). After the ASQ, participants are fitted with the PSG and the Dreem headband by the sleep technologist. During the PSG sleep study, the Dreem headband records EEG, pulse, oxygen saturation (SO2), movement, and respiratory rate. Many participants may undergo a split-night study with a continuous positive airway pressure (CPAP) device during their participation, as deemed necessary by the clinical staff pursuant to the sleep study.

The PSG data from the first 30 eligible participants will be manually scored by 5 sleep technologists. These manually-scored PSG data files (referred to as the training dataset) will be synchronized with Dreem data files from the same night and the synchronized files will be used to train Dreem's deep learning algorithms. Following training, the algorithms will be deployed to automatically score the final 30 participants' Dreem datasets (testing dataset). Finally, PSG records for the second 30 participants will be provided to the sponsor and manually scored by 5 sleep technologists. The manual scoring results will be compared to the Dreem automatic analysis to determine the accuracy of Dreem's apnea-hypopnea index (AHI) severity detection and sleep staging algorithms.

Eligibility Criteria:
Inclusion Criteria:

* 18-70 years of age
* Capable of providing informed consent
* Suspicion of sleep breathing disorder (both diagnostic and split-night studies)

Exclusion Criteria:

* Concomitant diagnosis of a sleep disorder other than sleep apnea syndrome or insomnia
* Morbid obesity (BMI \> 39)
* Use of benzodiazepines, nonbenzodiazepine (Z-drugs), or Gammahydroxybutyrate (GHB) the day/night of the study
* Concomitant diagnosis of cardiopulmonary or neurological comorbidities (such as heart failure, COPD, neurodegenerative conditions)
A Prospective, Single-center, Observational Study Aiming to Assess the Predictive Role of Flow Mediated Dilatation in Acute Coronary Syndromes, Combined With Echocardiographic and Biochemical Indices: The Novel Cor-IS Technology Will Also be Evaluated

A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices. The novel Cor-IS technology will also be evaluated.


Eligibility Criteria:
Inclusion Criteria:

1. Age \> 18 years
2. Patients hospitalized due to acute coronary syndrome (STEMI, NSTEMI)
3. Capability of providing written informed consent
4. Patients able to comply with the follow-up schedule of the study

Exclusion Criteria:

1. Patients with acute coronary syndromes classified as MINOCA, or type II myocardial infarction
2. Patients with rare acute coronary syndrome types, such as spontaneous coronary artery dissection or Takotsubo syndrome
3. Patients with congenital heart disease
4. Age \> 85 years
5. Patients with end stage chronic kidney disease
6. Patients with active malignancy or autoimmune diseases which limit their survival
7. Patients with expected survival \< 1 year due to other reasons
8. Suboptimal echocardiographic windows
9. Inability to provide written consent
10. Inability to comply with the follow-up schedule of the study
11. Pregnancy
12. Use of intravenous drugs
A Study of BGM0504 in Overweight or Obese Participants

The purpose of the study is to evaluate the influence of BGM0504 injection on gastric emptying and Pharmacokinetics of metformin and warfarin in overweight or obese participants


Eligibility Criteria:
Inclusion Criteria: √ Have a body mass index (BMI) of greater than or equal to (≥)28 kilogram per square meter (kg/m²) or ≥24 kg/m2 and less than (\<) 28 kg/m².

√ Willing and agreeable to commit to the duration of the study and undergo study procedures as instructed by the clinic staff.

Exclusion Criteria: √ History of chronic or acute pancreatitis.

* History of severe drug allergy or specific allergic disease or severe allergies.
* Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2(MEN-2).
* History of malignant tumors \[except carcinoma in situ with no recurrence within 5 years (except for malignant melanoma in situ), skin basal cell carcinoma and squamous cell carcinoma\].
* Suspected or confirmed history of alcohol or drug abuse;
* Any chronic infections likely to interfere with study conduct or interpretation such as hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency virus (HIV) or treponema pallidum (TP).
* Donation or loss of 400 mL or more of blood within 3 months prior to screening, or blood donation during screening or within 3 months after the end of the trial.
* Pregnant or lactating woman.
* Any disorder, unwillingness, or inability not covered by any of the other exclusion criteria, which in the Investigator's opinion, might jeopardize the participant's safety or compliance with the protocol.