cyrilzakka/clinical-trials huggingface dataset:
Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Sarcopenia

This study will investigate the effects of 12 months of high-intensity progressive resistance training compared with a control group on fall-rate in older adults with sarcopenia.

Despite the wealth of theoretical benefits, existing literature on resistance training for falls prevention is not conclusive, given the sub-optimal resistance training paradigms, poor study quality, and use of multimodal training interventions, precluding isolation of the resistance training benefits. It is also possible that resistance training benefits for falls reduction will be most evident in those with sarcopenia to begin with as a risk factor for their falls. We will therefore conduct a randomised, controlled trial assessing the effects of resistance training reduce falls in the oldest old adults with sarcopenia, as well as to increase strength and muscle mass.

Eligibility Criteria:
Inclusion Criteria:

* Aged 80 years or older
* Low muscular strength (grip strength: \<39.6 kg for males and \<21.8 kg for females or chair stand \>15 seconds)
* Community-dwelling incl. independent senior housing
* Ambulatory without supervision or physical assistance from another person. Assistive devices such as canes/crutches/walkers allowed.
* Able to see and hear sufficiently to undertake assessments and partake in the planned exercise training.

Exclusion Criteria:

* Pre-existing diagnosis of dementia
* Moderate or severe cognitive impairment (score \<18 on the Mini-Mental State Examination)
* Living in institutional care
* Non-ambulatory or requiring person or wheelchair to assist when walking
* Degenerative neurological and neuromuscular disease/disorder significantly influencing gait and mobility (e.g. amyotrophic lateral sclerosis \[ALS\] and Parkinson's disease).
* Amputation (other than toes)
* Contraindications to resistance training
* Unstable fracture
* Inability to comply with study requirements
* Currently undertaking progressive resistance training
Insulin on Post Burn Hypermetabolism

The purpose of this study is to examine the effects of insulin on helping burn patients recover faster from their burns.

Severe injuries produce profound hypermetabolic stress responses which cause severe loss of lean body mass and muscle wasting, immunologic compromise, slowed wound healing, and related bone loss, all which contribute to increased morbidity, mortality, and prolonged recovery from injury. The results of hypermetabolism persist for weeks to months depending on the severity of the insult. Massive burns can cause severe catabolism and are an excellent model to study the general effects of injury on protein metabolism. Severe burns are characterized by dramatic increases in energy utilization and alterations in the metabolism of carbohydrates, fat, and protein.

Insulin treatment improves net protein synthesis in the severely burned, principally through improved muscle protein synthesis. Although controversy exist as to whether insulin is effective as an anabolic hormone through increasing protein synthesis or decreasing protein breakdown, we believe that consideration of the methods and experimental protocols used in the various studies bear consideration when evaluating this topic.

Eligibility Criteria:
Inclusion Criteria:

* Burn equal to or greater than 20% total body surface area (TBSA)
* Between the ages of 18-72 years
* Burns occurred within 14 days of coming to burn center

Exclusion Criteria:

* Heart attack within 3 months
* Have or have had cancer
* Seizure disorder
* Pregnancy
* Pre-existing arterial insufficiency
* Diabetes or known history of hypoglycemia
* Allergy to iodine or shellfish
Skills Video Intervention for Chinese/Chinese Americans

This is a study that aims to test a coping skills intervention delivered via brief animated videos for Chinese and Chinese American college students.

We are interested in seeing whether a brief video-based Dialectical Behavior Therapy skills training intervention that incorporates Western psychotherapy components and Eastern philosophies would be perceived as relevant and useful for this culturally unique yet diverse group. During the study, participants will (1) complete a 20-min online baseline questionnaire; (2) complete a brief survey each day using a phone App for up to four weeks; and may (3) receive a video each day during the intervention.

Eligibility Criteria:
Inclusion Criteria:

* age 18 or older
* identifying as Chinese or Chinese American
* interested in learning coping skills to regulate emotions
* having a smart-phone compatible with the research mobile phone app
* matriculated at the local University for the current semester

Exclusion Criteria:

* currently receiving routine mental health services
* not able to read or write English
* not able to provide informed consent
Continuous Tremor Assessment During Daily Activities

The specific aim of this study is to evaluate if tremor severity and quality of life can be improved more using continuous home monitoring along with traditional assessments versus traditional assessments alone.


Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with essential tremor
* Currently taking medication to control tremor

Exclusion Criteria:

* Cognitive limitations that prevent comprehension or execution of study protocol
Immediate Effects of Upper Thoracic Manipulation on Skin Surface Temperature of T3 Vertebral Region and Biceps Brachii Muscle

The aim of the present study was to assess the immediate effects of upper thoracic manipulation on skin surface temperature in the region of the T3 vertebra and biceps brachii muscle in healthy women. It is a randomized controlled blind study. Twenty-six healthy women of the university community were randomly allocated to an experimental group (n = 13) and a placebo group (n = 13). A single session of the upper thoracic spine manipulation (segment T3)was performed. Infrared thermography was used to determine changes in skin surface temperature in the region of T3 and the biceps brachii muscle, which would indirectly reflect sympathetic activity. Images were taken prior to manipulation, immediately after and both five and 10 minutes after manipulation. Repeated measures ANOVA with the post hoc Bonferroni test and the independent samples t-test were used for the intragroup and intergroup comparisons, respectively, with the level of significance set to 5%.


Eligibility Criteria:
Inclusion Criteria:

* Healthy women
* 18 and 30 years of age

Exclusion Criteria:

* use of vasoactive medication
* body mass index greater than 25 kg/m2
* having undergone spinal manipulation in previous month
* and any red flag sign, such as malignant tumor, inflammatory or infectious disease that contraindicated manual therapy
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion

The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and remineralization. A positive control i.e fluoride containing toothpaste marketed in EU will also be compared to non-fluoride toothpaste.

The aim of this study is to assess the remineralization effects of two EU gel to foam toothpaste formulations with 1450 parts per million (ppm) of fluoride as sodium fluoride (NaF) and 5% potassium nitrate (KNO3) versus a non-fluoride (0 ppm F)/KNO3 toothpaste as a negative control. The two experimental gel to foam toothpaste formulations differ in their relative dentine abrasivity (RDA) values which is an in-vitro measure of a toothpaste abrasivity to the dentinal tissues. A marketed toothpaste containing NaF and KNO3 will serve as a positive control.

Eligibility Criteria:
Inclusion Criteria:

* General and Oral Health: Good general health with (in the opinion of the investigator) no clinically OST and OHT examinations.
* Oral Requirements:

  * An intact maxillary dental arch suitable for the retention of the palatal appliance and an intact mandibular dental arch. Subjects may have fixed bridges replacing missing teeth.
  * A gum base stimulated whole saliva flow rate ≥ 0.8 g/min and an unstimulated whole saliva flow rate ≥ 0.2 g/min.
* Contraception: Women of childbearing potential who are, in the opinion of the investigator, practicing a reliable method of contraception.

Exclusion Criteria:

* Oral Health:

  * Current active caries or periodontal disease that may compromise the study or the health of the subjects.
  * Lesions of the oral cavity that could interfere with the study evaluations, including severe gingivitis, grossly carious lesions, periodontitis and other severe periodontal disease.
* Allergy/Intolerance: Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
* Clinical Study/Experimental Medication:

  * Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit
  * Previous participation in this study
* Substance abuse: Recent history (within the last year) of alcohol or other substance abuse.
* Pregnancy: Women who are pregnant or who are intending to become pregnant over the duration of the study
* Breast-feeding: Women who are breast-feeding
Epidemiology and Co-Reactivity of Novel Surfactant Allergens

The primary objectives of this study are to identify positivity rates to three novel surfactants (ingredients used in soaps, detergents, and other cleansers that serve to lower the surface tension of the skin and remove debris) and co-reactivity with other surfactants in patients with known surfactant sensitivity on skin patch testing. The investigators hypothesize that subjects who previously tested positive to known allergenic surfactants (cocamidopropyl betaine, stearamidopropyl dimethylamine, dimethylaminopropylamine, coconut diethanolamide, oleamidopropyl dimethylamine, and decyl glucoside) may demonstrate co-reactivity to the three novel surfactant sensitizers (sodium lauroyl sarcosinate, isostearmidopropyl morpholine lactate, and disodium lauroamphodiacetate) on skin patch testing.


Eligibility Criteria:
Inclusion Criteria:

1. Documentation of a previous contact allergy to one or more surfactant(s) on our screening series including:

   * cocamidopropyl betaine
   * stearamidopropyl dimethylamine
   * dimethylaminopropylamine
   * coconut diethanolamide
   * oleamidopropyl dimethylamine, and
   * decyl glucoside
2. Age 18 years or greater.

Exclusion Criteria:

1. Pregnant or lactating women
2. Use of systemic therapy (corticosteroid, immunosuppressive agents, cytostatics, pentoxifylline, leukotriene antagonists or other medication known or suspected to have an effect of ACD) within two weeks prior to participation
3. Use of intramuscular steroids in the last month.
4. Phototherapy (PUVA or UVB) within two weeks prior to participation.
5. Direct sunlight or tanning booth use to the back within the two weeks prior to participation.
Effectiveness of Fecal Microbiota Transplantation as add-on Therapy in Mild-to-moderate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic immune-mediated inflammatory bowel disease (IBD) that almost always affects the rectum and often extends to the more proximal colon. UC usually begins at a young age (15-30 years), most patients (\~ 85%) have a mild or moderate activity, characterized by periods of exacerbation and remission. Considering the important pathogenetic role of gut dysbiosis, recently, as an additional method of treating UC, it is considered a modification of altered gut microbiota using various drug and non-drug methods. One such method is fecal microbiota transplantation (FMT), consisting of the simultaneous replacement of the gut microbiota of a sick recipient with fecal material from a healthy donor. Even though so far the only officially approved indication for FMT is recurrent Clostridium difficile infection, however, the effectiveness of FMT is currently being studied in the treatment of other gastrointestinal and non-gastrointestinal pathologies, including UC. To date, several controlled and uncontrolled studies have been conducted to study the effectiveness of FMT in UC, showing encouraging results. This study aimed to assess the clinical and microbiological efficacy, tolerability, and safety of FMT as add-on therapy to basic therapy, in patients with mild-to-moderate UC.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-60;
* Endoscopically and morphologically confirmed UC;
* Negative results of stool culture for the presence of pathogenic bacteria (Shigella spp., Salmonella spp., Campylobacter spp., Yersinia spp.) and toxin-producing Clostridioides difficile;
* partial Mayo score of 4-6;
* Mayo endoscopic subscore ≥1;
* Fecal calprotectin \> 150 mcg/g
* Treatment with mesalazine at a daily dose of 3 g during the last 4 weeks

Exclusion Criteria:

* Pregnancy, planning pregnancy or breastfeeding;
* Postponed operations on the abdominal cavity;
* Severe mental disorders, alcohol or drug abuse;
* Use of systemic corticosteroids, biological agents, and probiotics within 8 weeks before study
* Any condition or circumstance that would, in the opinion of the investigator, prevent completion of the study or interfere with analysis of study results.
Comparison of the Pharmacokinetics of Three Generic Medications and Their Respective Brand Preparations

Generic describes a pharmaceutical product that does not have a brand name or trademark. Generic medications should be the equivalent of brand medications. Only their price should be different. The active ingredient of the generic medication has to be within a window of 80 to 125% of the original in the blood. There are reports that this standard is not always followed after the medication has been on the market. Indeed, it was observed that some patients previously stable on original medications relapsed when switched to a generic. Several factors could account for this problem. Such problems have been reported for Pindolol, Quetiapine, and Trazodone. Some properties of specific brands of the generics and the original brands will be examined for these three medications. The three original medications used in this study are the Visken, the Seroquel, and the Desyrel. The three generics are the Teva-pindolol, the Teva-Quetiapine, and the Teva-Trazodone. They are all available on the Canadian market by prescription.


Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteers (absence of diseases: psychiatric, physical, neurological, metabolic,...)

Exclusion Criteria:

* Psychiatric disorder
* Hepatic disease
* Renal disease
* Gastrointestinal disease
* Hematological disease
* Smokers
* Physical and/or neurological disease
* Positive urine drug screen
* Abnormal blood pressure
* Abnormal Electrocardiogram
* Abnormal urine/blood analysis (sodium, potassium, chloride, creatinine, urea, ALT, AST, total protein, glucose, and TSH)
* Taking medication
* Have donated 50 mL to 499 mL whole blood within 30 days and more than 499 mL whole blood within 56 days preceding entry into this study
Low Carbohydrate Diet vs. High Carbohydrate Diet in Type 1 Diabetes

The aim of the study is to investigate glycemic control during a low carbohydrate diet compared with during a high carbohydrate diet in adults with insulin pump treated type 1 diabetes.


Eligibility Criteria:
Inclusion Criteria:

* Type 1 diabetes ≥3 years
* Insulin pump use ≥1 year
* HbA1c ≥53 mmol/mol (7.0%)
* BMI 20-27 kg/m2
* Willingness to count carbohydrates and use the insulin pump bolus calculator for all boluses during the intervention periods
* Willingness to use continuous glucose monitoring consistently during the intervention periods

Exclusion Criteria:

* Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods
* Use of SGLT-2-inhibitors
* Use of corticosteroids during or within 30 days prior to the intervention periods
* Celiac disease
* Inflammatory bowel disease
* Macroalbuminuria
* Active proliferative retinopathy combined with an HbA1c ≥ 75 mmol/mol (9.0%)
* Known or suspected alcohol or drug abuse
* Other concomitant medical or psychological condition that according to the investigator's assessment makes the patient unsuitable for study participation
Kinesiotaping Effect Glenohumeral Shoulder Subluxation

To evaluate the effectiveness of the kinesiotaping on pain, recovery of movement and daily life activities in Turkish hemiplegic patients.


Eligibility Criteria:
Inclusion Criteria:

* (1) 18 to 90 years of age, (2) stroke onset within one year, (3) shoulder subluxation in the involved upper extremity and (4) being oriented and cooperative.

Exclusion Criteria:

* (1) global aphasia, (2) malignancy, (3) previous shoulder pain or surgery, (4) other neuromuscular disorders and (5) severe cardiopulmonary disease that affects daily life activities.
Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction

The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).

CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.

Eligibility Criteria:
Inclusion Criteria:

* Patients with AMI after successful reperfusion
* Healthy volunteers in control group

Exclusion Criteria:

* No reperfusion
Incidence of Pulmonary Embolism During Temporary Pacing Via Femoral Versus Subclavian Vein

Temporary pacing via femoral vein is used widely in mainland China, because of its feasibility and simplicity. However, pulmonary embolism often occurred after the procedure. It is not known that whether there was any difference in incidence of pulmonary embolism between via different approaches. This randomized and multi-center study was designed to verify whether temporary pacing via subclavian vein has lower incidence than via femoral vein.


Eligibility Criteria:
Inclusion Criteria:

* 18 years old or older
* There is indication for temporary pacing
* Patients agreed to participate in the clinical trial and sign a written informed consent

Exclusion Criteria:

* History of pulmonary embolism or deep vein thrombosis
* Devices existing in vein system
* Patients who could not receive randomization
* Severe coagulation disorder
* Severe liver, kidney dysfunction
* Mental diseases
* Pregnancy
* Patients investigators believed not suitable for enrollment
Hormones and Social Anxiety Disorder Treatment

The purpose of this study is to determine whether power posing (i.e., holding poses associated with dominance and power), compared to submissive posing or rest, prior to exposure therapy for social anxiety disorder: 1) leads to a temporary increase in testosterone levels and/or 2) facilitates exposure therapy outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Outpatients between the ages of 18 to 70 years of age with a primary psychiatric diagnosis (designated by the patient as the most important source of current distress) of social anxiety disorder as defined by DSM-5 criteria, with fear of public speaking endorsed as a primary concern.
* Willingness and ability to participate in the informed consent process and comply with the requirements of the study protocol.

Exclusion Criteria:

* Current use of testosterone enhancing products (i.e., gels, creams, or injections)
* A lifetime history of bipolar disorder, schizophrenia, psychosis, or delusional disorders; organic brain syndrome, mental retardation or other cognitive dysfunction that could interfere with capacity to engage in therapy; a history of substance or alcohol abuse or dependence (other than nicotine) in the last 6 months.
* Entry of patients with other mood or anxiety disorders will be permitted in order to increase accrual of a clinically relevant sample; however in cases where SAD is not judged to be the predominant disorder, participants will not be eligible.
* Patients with significant suicidal ideation or who have enacted suicidal behaviors within 6 months prior to intake will be excluded from study participation and referred for appropriate clinical intervention.
* Patients using psychotropic medication (e.g., antidepressants, anxiolytics, beta blockers) must be on a stable dose for three weeks prior to initiation of randomized treatment.
* Significant personality dysfunction likely to interfere with study participation.
* Patients with a current or past history of seizures.
* Any concurrent psychotherapy initiated within 3 months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of the SAD is excluded. Prohibited psychotherapy includes CBT or psychodynamic therapy focusing on exploring specific, dynamic causes of the phobic symptomatology and providing management skills. General supportive therapy initiated \> 3 months prior is acceptable.
* Prior non-response to adequately delivered exposure (i.e., as defined by the patient's report of receiving specific and regular exposure assignments as part of a previous treatment).
* Patients with a history of head trauma causing loss of consciousness, seizure or ongoing cognitive impairment.
* Subjects with back pain issues or medical conditions that would make it difficult to hold posture manipulations.
* Insufficient command of the English language.