cyrilzakka/clinical-trials huggingface dataset:
PEP Breathing Versus Incentive Spirometry on Dyspnea and Sputum Profile in Bronchiolectasis Patients

Bronchiolectasis is the manifestation of chronic bronchitis characterized by saccular dilatation of the terminal bronchioles \& bronchiectasis refers to abnormal dilatation of the bronchi. In bronchiolectasis more proximal bronchi may or may not show radiological changes. Airway dilatation can lead to failure of mucus clearance and increased risk of infection. Pathophysiological mechanism of bronchiectasis/bronchiolectasis include persistent bacterial infections, deregulated immune responses, impaired mucociliary clearance and airway obstruction. Treatment is directed at reducing the frequency of exacerbations, improving quality of life. Although no therapy is licensed for bronchiectasis by regulatory agencies, evidence supports the effectiveness of airway clearance techniques, antibiotics and mucolytic agents. Enhancing effective expectoration of stagnated bronchopulmonary secretions, usually with physiotherapy support, is key to management. There are different methods for delivering chest physiotherapy, such as the active cycle of breathing technique, postural drainage, (PEP) and oscillating PEP devices. The objective of the study is to compare the effects of PEP \& Incentive spirometry techniques on bronchiolectasis patients.

The study will be a randomized clinical trial. Total 24 subjects will be assigned randomly into two groups by using convenient sampling technique. Baseline treatment will be same (chest physiotherapy) in both groups. Group A will use PEP and Group B will use incentive spirometry technique for total 60 repetitions (15 repetitions 2 sets, two times per a day) 5 sessions per week and total 4 weeks. Dyspnea severity index and cough \& sputum assessment questionnaire (CASA-Q) would be used as an outcome measurement tools. Measurements will be taken at Baseline, and at the end of the 4 weeks treatment session. After assessing the normality, data will be analyzed by using parametric and non-parametric tests.


Eligibility Criteria:
Inclusion Criteria:

* Age group of 22 to 85 years
* Both GenderCOVID-19 negative
* Indoor patients
* Ability to use PEP devices
* Diagnosed Bronchiolectasis Patients (through CT scan, X-Ray)

Exclusion Criteria:

* Rib fracture
* Neurological problems
* Lungs carcinomas
* Any other serious comorbidity
Prevalence of HPV Infection Using Self-sampling

Background: Currently prevalence of HPV infections for high risk strains among young women in Switzerland is unknown. In addition, since 2008 a vaccination program to prevent these infections has been implemented in a number of cantons, but its actual population impact is currently unknown. For now, HPV screening in Switzerland is mainly performed by gynecologists or during gynecological consultation at hospital. This method is certainly effective, but expensive; population coverage of screening is still insufficient. A whole segment of the target population does not participate in this screening especially young people of foreign origin, for various reasons: economic cost, no gynecological, and for other reasons.

Several studies raise the effectiveness and efficiency of self-sampling to increase coverage of screening, and the rate of participation of non-participants. Through this study, the investigators evaluate effectiveness of this vaccination on the prevalence of HPV infections using HPV prevalence kit and assess evolution of infection and clearance of HPV virus during 5 years in a population of young unvaccinated and vaccinated women.

Method: During the study, each participants will perform a vaginal swab sampling by auto to research HPV. These samples will be sent to a laboratory where HPV typing is done by PCR using the Anyplex ™ II technology.

The study will focus on a sample of 400 young women. Participants must complete a questionnaire containing demographic questions and their HPV immunization status. Vaccination coverage expected in this population is about 50%. Depending on the state of vaccination, two different groups will be vaccinated vs unvaccinated (200 women per group). The cases of HPV infection are then calculated for each group and compared as a function of the status of vaccination. Statistical tests will be applied McNemar's test for comparison between the HPV prevalence rates between the 2 groups.

Expected Results: This study will allow us to confirm the possibility of using self-sampling as a method of screening and monitoring of HPV infections in the general population, it will also enable us to document the effectiveness of HPV vaccination by comparing prevalence rate of HPV infections among a group of young girls vaccinated and not vaccine and assess evolution of infection and clearance of HPV virus.


Eligibility Criteria:
Inclusion Criteria:

* • Eligible women aged between 18-31 years attending of Haute Ecole de Santé - Genève and Faculty of Medicine at the University of Geneva.

  * Understands study procedures and accepts voluntarily to participate by signing the informed consent form (ICF)

Exclusion Criteria:

* • History of hysterectomy or treatment on the cervix during the last 12 months
UMBRELLA - Incidence of Arrhythmias in Spanish Population With a Medtronic Implantable Cardiac Defibrillator Implant

The purpose of the study is to analyze the different patient profiles implanted with an Implantable Cardiac Defibrillator (ICD) in Spain (guidelines adoption) and the patient prognosis as a function of clinical profile, implant indication, arrhythmias incidence, treatments or device programming.

Umbrella is a prospective and retrospective cohort study.

Eligibility Criteria:
Inclusion Criteria:

* Patients with a Medtronic Implantable Cardiac Defibrillator (ICD) according to guidelines.
* Patients with CareLink home Telemonitoring System.

Exclusion Criteria:

* Unwillingness or inability to sign study written informed consent and/or CareLink consent.
Neural Mobilization and Conventional Physical Therapy After Laminectomy

This study was conducted to evaluate the effect of addition of neural mobilization to a standard post-operative physical therapy program in patients with lumbar laminectomy.

After Laminectomy, patients are suffering from many problems as pain, weakness. This study was conducted on two groups of patients who underwent lumbar Laminectomy as a surgical treatment for lumbar canal stenosis. The control group received TENS and strengthening exercises, while the study group received neural mobilization in addition to the program that was given to the control group. The outcome measures include pain intensity, nerve root compression and functional level which were measured pre-treatment and post-treatment through using visual analogue scale, H-reflex latency and Oswestry Disability Index (ODI) respectively.

Eligibility Criteria:
Inclusion Criteria:

* Aged from 35-50 years.
* Underwent lumbar laminectomy of one or two levels.

Exclusion Criteria:

* Patients who had arthritis in the joints of the lower limbs (which would limit walking).
* Patients who had tumors, fractures or infections of the spine.
* Patients who had diabetes mellitus.
* Patients who had polyneuropathy.
* Patients who had evidence of spinal cord compression.
* Patients who had previous spinal surgery.
* Patients who had spinal stability problems (e.g. spondilo-listhesis, spondilolysis).
* Patients who had sensory loss.
Assisted Intubation

The study investigates assisted intubation using a videolaryngoscope in anesthesia.


Eligibility Criteria:
Inclusion Criteria:

* Easy airway assessment

Exclusion Criteria:

* Difficult airway
* ASA 3
Thromboprophylaxis for Patients in ICU With COVID-19

The respiratory distress that goes with COVID-19 infection has been related to a procoagulant state, with thrombosis at both venous and arterial levels, that determines hypoxia and tissue dysfunction at several organs. The main sign of this thrombotic activity seems to be the D-Dimers, that have been proposed to identify patients with poor prognosis at an early stage.

Knowledge on how to prevent or even treat this procoagulant state is scarce. COVID-19 patients may be out of general thromboprophylaxis recommendations, and recent studies suggest a better prognosis in severe COVID-19 patients receiving anticoagulant therapy with low molecular weight heparin (LMWH). However, the LMWH efficacy and safety, mainly in patients admitted to an Intensive Care Unit, remains to be validated.

Many reports have postulated a procoagulant state along with the respiratory distress caused by coronavirus SARS-CoV2. A complex physiopathology has been proposed trying to explain this profile, mainly based on the thromboinflammatory concept, with thrombosis at both venous and arterial levels. Microvascular thrombi impair the blood flow all over the body, with a vascular shunt due to capillary obstruction, that determines hypoxia and tissue dysfunction at several organs, being the lung the more affected one.

Although D-Dimers (DD) are not specific indicators of clot formation, its elevation, in combination with other parameters (hyperfibrinogenemia, mild thrombocytopenia) may suggest a systemic coagulation activation with an increase of thrombin generation and fibrinolysis. In fact, in a retrospective Chinese analysis, a DD higher than 1000 ng/ml was proposed to identify patients with poor prognosis at an early stage.

Nevertheless, knowledge on how to prevent or even treat this procoagulant state is scarce. Thromboprophylaxis with low molecular-weight heparin (LMWH) is recommended in most medical patients admitted to the hospital and in nearly all patients in an Intensive Care Unit (ICU). But COVID-19 patients may be out of these recommendations, and some treatment schemes has been proposed, although how to decide the suitable LMWH for each clinical situation is controversial. Recent retrospective studies suggest a better prognosis in severe COVID-19 patients receiving anticoagulant therapy with LMWH. However, the LMWH efficacy and safety, mainly in COVID-19 patients admitted to the ICU, remains to be validated.

Eligibility Criteria:
Inclusion Criteria:

* Confirmed SARS-CoV2 infection from a respiratory tract sample using a polymerase chain reaction assay.
* Admitted to ICU

Exclusion Criteria:

* Non-confirmed SARS-CoV2 infection
* No data at first day ICU admission
* Patient with do-not resuscitate orders
* Patient who did not meet the outcomes of death or ICU discharge by the time of study completion date
Long Term Memory Preoperative Preparation Reduce Post Operative Behavioral Change

The study is designed to test the hypothesis that long term memory created by preoperative video information can reduce the incidence of post operative behavioral changes.

Emergence agitation (EA) and Post operative behavioral change (PHC) are unpleasant experiences occurred in children after general anesthesia (GA). Previous study reported that the patient who had marked EA tended to have new-onset of postoperative maladaptive behavioral changes.Both pharmacologic and non pharmacologic interventions such as preoperative video information, hand held video games were used to reduce preoperative anxiety, EA and Post operative behavioral changes. In term of memory creation, short term memory (STM) was created. Later that the formation of memory trace requires time, and that this trace remains fragile until the long term memory formation process has been completed. In this study, the investigators hypothetize that long term memory created by preoperative video information can reduce the incidence of post operative behavioral changes.

Eligibility Criteria:
Inclusion Criteria:

* outpatient elective surgery
* aged between 3-14 years
* ASA physical status I-II

Exclusion Criteria:

* mental retardation
* patient's telephone contact not available
* emergency case
* having ICU admission plan postoperative
The Acute Effects of Different Stretching Methods in Individuals With Subacromial Impingement Syndrome

The purpose of this study is to investigate and compare the acute effects of isolytic and static stretching training in individuals having subacromial impingement syndrome with glenohumeral internal rotation deficit. Isolytic group will receive isolytic stretching in modified cross body position. Static group will receive static stretching in modified cross body position. Stretching groups will be evaluated before and just after stretching exercise. Control group will receive no stretching. Control group will be evaluated for the first time and then will be waited until the duration of the stretching exercise program. Afterwards, second evaluation will be performed

There is no information in literature about the acute effects of isolytic stretching exercise in individuals having subacromial impingement syndrome with glenohumeral internal rotation deficit. The purpose of this study is to investigate and compare the acute effects of isolytic and static stretching training in individuals having subacromial impingement syndrome with glenohumeral internal rotation deficit.

In modified cross body position, static stretching group will perform active-assistive static stretching by the physiotherapist whereas isolytic stretching group will perform active-assistive isolytic stretching. Stretching exercises will be applied five times each for 15 seconds. After each stretching there will be a resting period for 5 seconds. Control group will receive no stretching. They will be handed a brochure about the stretching techniques and its role in injury prevention. Isolytic and static stretching groups will be evaluated before and just after stretching exercise. Control group will be evaluated for the first time and then will be passively waited until the duration of the stretching exercise program (approximately 4-5 min). Afterwards, second evaluation will be performed.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of subacromial impingement syndrome
* Glenohumeral internal rotation range of motion of the affected shoulder should be less than other shoulder and bilateral shoulder internal rotation range of motion difference should be ≥15 º
* Pain with resisted arm elevation or external rotation as well as a minimum of 3 of 5 positive subacromial impingement syndrome tests, painful arc, pain or weakness with resisted external rotation, Neer, Hawkins and Jobe tests .
* Ability to complete the entire study procedure

Exclusion Criteria:

* An inability to elevate the involved arm greater than 140 degree in the scapular plane
* A 50% limitation of passive shoulder range of motion in \>2 planes of motion
* Pain \>7/10
* A history of fracture to the shoulder girdle
* Systemic musculoskeletal disease
* History of shoulder surgery,
* Glenohumeral instability (positive apprehension, relocation or positive sulcus test) or positive findings for a full thickness rotator cuff tear (positive lag sign, positive drop arm test or marked weakness with shoulder external rotation)
Wearable Electronic Breath Sound Sensing Device

This study will assess the ability of a wearable stethoscope to monitor wheezing in high-risk asthma patients admitted at Children's Healthcare of Atlanta.

This study is important to assist in the health management of patients with chronic lung diseases that can experience exacerbations leading to their health worsening and requiring hospitalization. The population that will be approached for this study will include 10 pediatric subjects hospitalized at Children's Healthcare of Atlanta for an asthma-related exacerbation. Participants will wear the patches for up to 8 hours on their chest and back wall from their date of consent until their hospital discharge. This may range from the participant taking part in 1 to 14 visits that could last up to 8 hours.

The main goal of this study is to evaluate the ability of a novel wearable breath sound sensor (wearable stethoscope) to continuously monitor breath sounds, specifically wheezing, in pediatric asthma patients during hospital admission. The data collected will be used to develop a wheeze detection algorithm. The breath sound recordings from this device will not be used for any medical decision-making or treatment changes, and all study participants will continue to receive routine medical management per standard of care guidelines.

Eligibility Criteria:
Inclusion Criteria:

* Age 6-17 years
* Diagnosis of persistent asthma
* Being treated for an acute asthma exacerbation
* Parent can speak and understand English

Exclusion Criteria:

* Unable to provide consent for the study
* History of prematurity
* History of other chronic lung conditions - cystic fibrosis, bronchiectasis, or primary ciliary dyskinesia
* History of latex allergy or allergy to medical tape adhesive
* Patients currently using another medical device - implanted pacemaker or vagal nerve stimulator or diaphragm pacing device
Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia

The aim of this study is to investigate the influence of the use of different types of phototherapy on different lymphocytes subsets CD4 and CD8 in the treatment of hyperbilirubinemia in neonates.


Eligibility Criteria:
Inclusion Criteria:

Term neonates with a gestational week higher than 37weeks, according to the guidelines of the American Academy of Pediatrics (2004) which stated that gestational ages of newborns are determined according to the first day of the mother's last menstrual period (by the mother's statement) and were additionally confirmed by the Ballard scoring system (Ballard et al., 1991) and antenatal ultrasonographic estimation or obstetric records if present.

* Clinically significant indirect hyperbilirubinemia requiring phototherapy in the first week of life.
* No pathologic etiological factors for hyperbilirubinemia

Exclusion Criteria:

* Total bilirubin level of \>20 mg/dl.
* Prematurity.
* Sepsis.
* Congenital anomaly.
* Elevation in direct bilirubin level.
* History of immune deficiency the family.
* History of preeclampsia or any other diseases or drug use of the mother
Neurodynamic Mobilization and Foam Rolling

The purpose of this study was to assess the acute effects of a single NM treatment session on DOMS and to compare them with those of one foam roller (FR) session. Following the damaging plyometric exercise bout, the participants were randomly assigned in a counter-balanced fashion to either a FR or NM treatment group; treatments were administered 48-h post-exercise. The dependent variables were recorded before the exercise, 48-h post-exercise before treatment, and immediately post-treatment.

Currently, the foam-rolling massage is often used by athletes from many sports. However, there are a few studies on the effects of foam-rolling massage and they have conflicting results regarding the improvements in ROM and muscular performance. In contrast, neurodynamic mobilization (NM) is a manual therapy method used to assess and treat neuromuscular disorders. It includes gliding techniques and tensile techniques. Gliding techniques or "sliders" are intended to produce a sliding movement between neural structures and adjacent nonneural tissues. NM has been shown to reduce pain and soreness and improve ROM. However, no studies have investigated its effects after exercise-induced muscle soreness or DOMS.

Eligibility Criteria:
Inclusion Criteria:

* All subjects were moderately active (Category 2) as assessed by the International Physical Activity Questionnaire (IPAQ) questionnaire (Craig et al., 2003).
* None of the subjects had a recent history of intensive training, heavy eccentric resistance, or plyometric exercise, and all subjects were free from musculoskeletal disorders in the last year.
* All subjects were asked to refrain from unaccustomed exercise during the experimental period, and the subjects abstained from all medications and dietary supplements during the experimental period and between testing sessions.

Exclusion Criteria:

* Sedentary
* patients with pain
Conditioning With Volatile Anesthetics in Liver Transplantation

The gap between the number of candidates for orthotopic liver transplantation and the availability of suitable liver grafts has led to a rise in deaths on most waiting lists. Strategies applied in many centers to minimize this deficit include living donation or split of a cadaveric organ for two recipients, domino transplantation, and the use of so-called expanded criteria donors. Alternatively, conditioning of an organ would also allow protec-tion of the liver upon ischemia-reperfusion injury, possibly decreasing postoperative liver function and im-proving clinical outcome. The technique of conditioning with the volatile anesthetic sevoflurane is an easily applicable procedure which could be performed in any center worldwide.

Data and experience with sevoflurane attenuating ischemic-reperfusion injury in liver resection lead to the hypothesis of a beneficial effect of volatile anesthetics in liver transplantation. In this randomized controlled trial, patients will be randomly assigned to liver transplantation with propofol anesthesia (propofol group) or sevoflurane conditioning with the volatile anesthetic (sevoflurane group). Primary endpoint is postoperative peak of the transaminase (AST), secondary endpoints are complications, primary liver graft function, ICU and hospital stay. We hypothesis that patients with conditioning have an attenuated increase of transaminases as well as a better outcome.


Eligibility Criteria:
Inclusion criteria:

* Older than 18 years
* Patients undergoing liver transplantation
* Total or partial cadaveric liver transplantation
* Living related liver transplantation

Exclusion criteria:

* Patients unable to understand the German or Italian language
* Patients with known or suspected allergy to propofol, soja or egg
* Patients with norepinephrine infusion above 15 microg/min
* Intensive care patients with severe impairment of renal or pulmonary function (e.g. dialysis, hemofiltration, FiO2\>0.5)
Three Different Approaches for Ultrasound Guided Femoral Nerve Block for Patients Undergoing Total Knee Arthroplasty

Patients scheduled to have a surgery for Total Knee Arthroplasty will be assigned to one of three groups, each group will use a different approach using the ultrasound to guide the femoral nerve block as part of their treatment for controlling pain post-operatively.

This will be a prospective, single-blinded, randomized study. The patients will be randomly assigned to one of three groups:

Group I - single shot femoral nerve block Group II - continuous femoral nerve block - non stimulating catheter Group III - continuous femoral nerve block - stimulating catheter

Eligibility Criteria:
Inclusion Criteria:

* 18- 90 years old
* Scheduled for total knee arthroplasty

Exclusion Criteria:

* Redo surgery on the same knee
* BMI ≥45
* Radicular pain in the same leg
* Allergy to local anesthetics
* Opioid habituation
* Pregnancy
* Contraindication to regional block
* Inability to communicate with hospital staff or investigators.
* Neuropathy of any etiology in the surgical extremity.