cyrilzakka/clinical-trials huggingface dataset:
Teleconsultation in Ambulatory Care in France

Teleconsultation is a telemedicine medical act carried out remotely via information and communication technologies. This medical procedure has been legal in France since 2010 and reimbursed by the National Health Insurance under certain conditions since 2018. In 2020, following the COVID-19 epidemic, the lockdowns and the extension of the scope of financial coverage, 17 million teleconsultations have been reimbursed.

To date, few scientific studies have been published in France to precisely describe the use of the service giving access to outpatient teleconsultation, in particular since the major increase in activity linked to the COVID-19 epidemic.

The objective is to describe the use of the service giving access to outpatient teleconsultation carried out in France by teleconsultation companies and compare the use of the teleconsultation service according to the medical density of the territory.


Eligibility Criteria:
Inclusion Criteria:

* Patient who used the teleconsultation access service with one of the telemedicine companies member of the LET participating in the study
* Patient residing in France according to the written information (address and or postal code) given at registration to the telemedicine company
* Teleconsultation service used between August 1, 2021 and November 30, 2021
* Teleconsultation service used in the context of outpatient care (hospitals excluded)
* Teleconsultation service used for a teleconsultation with a doctor registered with the Medical Doctors Council in France
Influences of Cane Use on Voluntary Forward Stepping Movement and Associated Attentional Demands in Hemiplegic Patients

The purpose of this study was to examine the influence of cane use on the movement, kinetics, and associated attentional demands of performing a voluntary forward stepping movement in patients with stroke and age-matched healthy adults.


Eligibility Criteria:
Inclusion Criteria:

Healthy subjects

* Age ang Sex are correspond with the stroke subjects(between 30 and 75 years old)
* being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital

Stroke subjects

* between 30 and 75 years old
* stroke confirmed by ICD-10-CM (including I60, I61, I62, I63, I67, and I63.9)
* first stroke with single side hemiplegia and received acute treatment at NTUH
* being willing to sign an informed consent approved by the Human Subjects Committee of the National Taiwan University Hospital
* able to stand independently for 10 minutes and to forward step without ankle-foot orthosis
* Mini-Mental State Examination (MMSE) score at least 24

Excursion criteria:

Healthy subjects

* having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal disorders, or disorders from systematic diseases those would influence the belance or motor ability

Stroke subjects

* having unstable vital sign, unconsciousness, or obvious cognitive, perception, and language impairment, and couldn't communicate with the experimenters
* having other neurological diseases, or moderate to severe neuromuscular or musculoskeletal or cardiovascular disorders, or disorders from systematic diseases those will influence standing ability other than stroke
* having hemi-neglect or hemi-anopia
Activity on Prescription to Promote Physical Activity in Hospitalized Patients

This study tries to improve patient's activity by a "Prescription for Activity" led by physiotherapists in secondary health care setting.

Three groups are compared in regard to their increase of physical activity.


Eligibility Criteria:
Inclusion Criteria:

* aged 40-75 years
* self-dependent
* walk around at home alone
* German-speaking
* Ability to read and write
* Life expectancy \> 6 months
* Stable disease process expected for the next 6 months
* Time spend in hospital: \> 3 days, \< 4 weeks

Exclusion Criteria:

* Patients suffering from dementia
* Planned participation in rehabilitation
* severe functional limitations that precluded any increase in physical activity
* not living independently
Pre-surgical Motivation for Bariatric Surgery

A study investigating the motivations of patients who had undergone bariatric surgery using data collected from questionnaires given to patients prior to surgery.


Eligibility Criteria:
Inclusion Criteria:

* Undergone bariatric surgery at Singapore General Hospital and completed the life center questionnaire.

Exclusion Criteria:

-
AED/Statin Interaction Study

This study will evaluate the amount of the cholesterol-lowering drug atorvastatin available in the bloodstream, when taken together with the anti-seizure drugs lamotrigine or phenytoin.


Eligibility Criteria:
Key Inclusion Criteria:

* Body weight \>50kg (men) or \>45kg (women) and BMI within the range 19-32 kg/m2 inclusive.
* No clinically significant abnormality on clinical examination

Key Exclusion Criteria:

* History or evidence of drug or alcohol abuse or active tobacco use.
* Women of childbearing potential
* Use of prescribed or non-prescribed medications during and within 14 days of starting study medication.
EVEROLD LONG TERM FOLLOW-UP

Long Term Follow up of EVEROLD study


Eligibility Criteria:
Inclusion Criteria:

* Informed patients participating to the EVEROLD study
* Patient having completed the EVEROLD M12 follow-up visit
* Patient agreeing to participate in the observational study

Exclusion Criteria:

* Opposition to the use his medical data
* Patient under legal protection
Non-steroid Antiinflammatory Drugs to Heal Colles Fracture

It is believed that some painkillers (NSAID drugs) slow bone healing but the knowledge is based only on experimental studies with animals whose results are automatically translated for humans. The purpose is to examine whether these drugs slow bone healing and what relationship there is between different bone examinations, scan for osteoporosis, bone marker laboratory tests, radiological controls and histology of newly formed bone under a microscope.

One of the most popular painkillers in the world is known as NSAID (non-steroidal anti-inflammatory drugs). Many studies with animals have been made which show a clear tendency for delayed bone healing by taking NSAIDs.

It is known that an early intake of NSAIDs prevents ectopic ossification in patients, receiving total hip prosthesis. However, cases of prosthetic loosening and instability after 10 years were almost exclusively observed in the group of patients who received NSAIDs postoperatively. However, very few clinical studies still show this tendency. In this study we include patients with fresh fracture in the wrist; Colles fracture. The fracture may seem unstable when there is a lack of bone healing. These fractures are very common in the orthopaedic clinic.

Although there is no dislocation of the fragments, newly formed bone can be weaker as demonstrated by DEXA scanning (bone mineral density measurement). Histological examination of the healing bone can give a definitive answer whether the bone was affected or not. Thus, the possibilities of studying NSAIDs affect on bone healing in humans and the clinical significance are very positive.

Eligibility Criteria:
Inclusion Criteria:

* Patients giving written informed consent and authority
* Patients with Colles fracture who require surgery by means of an external fixation or type bridging with or without suture.
* Patients who clinically and radiographically are diagnosed for reposition and therefore require external fixation or type bridging with or without suture.

Exclusion Criteria:

* Patients who have been given adrenal cortex hormone.
* Patients who have been given non-steroid antiinflammatory drugs (NSAID).
* Patients who have not been giving written informed consent and authority.
* Patients who smoke more than 20 cigarettes daily.
* Patients who consume more than 14 drinks weekly.
* Lack of mental and physical ability to follow the directions according to the protocol.
* Medical contraindication to non-steroid antiinflammatory drugs.
A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn

This study aims to answer the question: Does oxytocin increase the pain threshold on thermal heat pain in the presence of vibration on an area of skin exposed to a mild sunburn?

The goal of this clinical trial is to test whether intravenous oxytocin increases the analgesic effect of vibration on heat pain threshold of skin that has been exposed to Ultraviolet-B (UV-B) burn (mild sunburn). Researchers will compare oxytocin (a hormone that naturally occurs in the body) to a placebo (a look-alike substance that contains no drug) to see if oxytocin works to increase the pain threshold (the lowest intensity at which one begins to perceive or sense a stimulus as being painful).

Eligibility Criteria:
Inclusion Criteria:

* Male or female \> 18 and ≤55 years of age, Body Mass Index (BMI) \<40
* Generally in good health as determined by the Principal Investigator based on prior medical history, and as assessed to be American Society of Anesthesiologists physical status 1, 2, or 3
* Fitzpatrick Scale rating I through III

Exclusion Criteria:

* History of skin cancer
* Dark enough skin complexion that would make it infeasible to determine the minimal erythematous dose of UV-B irradiation. Anyone Fitzpatrick Scale score \>3 will be excluded
* Neuropathy, chronic pain (located in any body location that is being treated), diabetes mellitus, or taking benzodiazepines or pain medications on a daily basis
* Pregnancy or currently breast feeding
* Subjects with current or history of ventricular tachycardia, atrial fibrillation or prolonged QT interval
* Subjects with past or current history of hyponatremia or at risk for hyponatremia; anyone taking thiazide diuretics, loop diuretics, combination diuretics, lithium, carbamazepine, enalapril, Ramipril, celecoxib, temazepam, gliclazide, glimepiride, glibenclamide, glipizide, omeprazole, pantoprazole, desmopressin, SSRI's, MAOI, or the recreational drug ecstasy
* Subjects with a known latex allergy
The Effect of the Quran on Quality of Life and Quality of Sleep in Breast Cancer

Objective: This study aims to investigate the effects of Quran on quality of life and sleep in patients receiving chemotherapy due to breast cancer.

Method: This study will be conducted with 40 patients with breast cancer receiving chemotherapy at Erzurum City Hospital Outpatient Chemotherapy Unit in a randomized controlled experimental design. Block randomization will be used in group assignment. The breast cancer patient identification form, European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Scale (QLQ-C30) and Pittsburg Sleep Quality Index (PSQI) will be used to collect research data. It is planned to collect research data with a total of four measurements during the application of the first, second, third and last protocols of chemotherapy.

Expected Results: As a result of the study, it is expected that Quran recitation will have a positive effect on quality of life and sleep in patients receiving chemotherapy due to breast cancer.


Eligibility Criteria:
Inclusion Criteria:

* Having breast cancer
* Being on chemotherapy
* Being on a chemotherapy protocol every 21 days
* Being over the age of 18
* Not having communication problems
* Being willing to participate in the study

Exclusion Criteria:

* Having a hearing problem
* Having an ear infection or any condition that prevents hearing
* Having other types of cancer other than breast cancer
Evaluation of Outcomes Following LASIK Surgery Using CustomVue

The aim of the study was to evaluate visual outcomes, contrast sensitivity, glare and induced high order aberrations induced by the new CustomVue software use for wavefront-guided LASIK.


Eligibility Criteria:
Inclusion Criteria:

* Myopia 0.00 to -6.00 D
* Astigmatism 0.00 up to -3.00 D
* Manifest refraction spherical equivalent (MRSE) up to -6.00 D.

Exclusion Criteria:

* History of ocular pathology
* Previous ocular surgery
* Large pupils (greater than 8mm diameter, infrared measurement)
* Thin corneas (preoperatively calculated minimal residual bed \< 250 um)
* Irregular astigmatism
* Asymmetric astigmatism
* Unstable refraction
* Any other condition that precludes the patient from undergoing LASIK
Use of Goggle Balloon to Improve Cecal Intubation During Colonoscopy

This study aims to look if use of goggle balloon can help to complete colonoscopy in patients with very redundant colons.

About 5% of colonoscopies are technically difficult because the colon is elongated or redundant. There is an increased risk of the colonoscope not reaching the cecum in these cases. One solution to this is to try to keep the colon shorter by not insufflating it with gas. In order to achieve that, in these cases the investigators typically fill the colon with water, which does not distend the colon as much. Another technique, which can improve visualization, is to use a device called the goggle balloon. This is a small balloon filled with a few mL of water which fits over the end of the colonoscope and pushes the colonic mucosa away from the end of the scope so that the luminal direction can be visualized with minimal insufflation. In patients with normal colons, the goggle balloon can be used to insert the colonoscope to the cecum with virtually no air or water filling. We aim to study if the goggle balloon can be used to help complete the colonoscopy in patients with redundant colons.

Eligibility Criteria:
Inclusion Criteria:

Referral for incomplete colonoscopy

Exclusion Criteria:

Known stricture or narrowing of the colon, prior colon resection
Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma

This study is a single-arm, multicenter clinical study to evaluate the efficacy and safety of Cadonilimab in combination with gemcitabine/cisplatin as a first-line treatment for recurrent or metastatic nasopharyngeal carcinoma.


Eligibility Criteria:
Inclusion Criteria:

1. The subject must sign the written informed consent form (ICF) voluntarily；
2. Age ≥18 years and ≤65 years；
3. Subjects with histopathological diagnosis of nasopharyngeal carcinoma；
4. Primarily metastatic (stage IVB as defined by AJCC staging system for NPC, eighth edition) or recurrent/metastatic NPC that is not amenable to local regional treatment or curative treatment and at least 6 months after radical treatment；
5. Has not received prior systemic treatment;
6. Has a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance Status
7. Subject must have a measurable target lesion based on RECIST v1.1;

Exclusion Criteria:

1. Allergic to monoclonal antibodies, any cadonilimab components, gemcitabine, cisplatin, and other platinum drugs;
2. Prior therapy as follow:

   Anti-PD-1, anti-PD-L1 or anti-CTLA-4; Concurrent medical condition requiring the use of cortisol (\>10mg/day Prednisone or equivalent dose) or other systematic immunosuppressive medications within 14 days before the study treatment（Except：inhalation or topical corticosteroids）.
3. Any active malignancy ≤ 2 years before randomization except for specific cancer under investigation in this study and any locally recurring cancer that has been treated curatively (eg, resected basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast)；
4. Female patients who are at pregnancy or lactation.
Developing Mental Health Supports for Autistic Students

The present study aims to expand the availability of emotional supports in order to promote successful transitions and longer-term outcomes for autistic students in PSE.

This study has three specific aims:

Aim 1: Identify mental health needs of autistic students to inform supports. Focus groups engaging key stakeholders will be used to understand the mental health needs of autistic college students and inform adaptation of two individualized mental health supports: 1) the ESP intervention and 2) protocols for monitoring mood and psychological distress.

Aim 2: Develop resources to inform and guide mental health care of autistic students. Focus group information will inform 1) adaptation of clinician (ESP-C) and self-guided (ESP-S) emotional support plans and monitoring protocols and 2) develop a "College Student Mental Health Guide" to aide autistic college students, their families and mental health professionals in proactive planning for mental health supports during PSE.

Aim 3: Assess the feasibility, acceptability and initial efficacy of the ESP-C and ESP-S.

The study will yield preliminary data to apply for additional funding to conduct a large-scale trial to validate these methods to monitor and support mental health of autistic adults. Information gathered from the study will also be used to inform development of a mental health guide for autistic students.

Eligibility Criteria:
Inclusion Criteria:

* Previous ASD diagnosis,
* Has smartphone (to access the ESP app)
* At least 6th grade Reading Comprehension on the WRAT-5. The WRAT-5 may not be required if a student has other evidence of age-appropriate reading level.
* Be currently enrolled in a Postsecondary Education (PSE) institution.

Exclusion Criteria:

* Not a students in a PSE Institution or do not have diagnosis of ASD
* Score below a 6th grade Reading Comprehension on the WRAT-5
* Unable to understand English
* No access to a compatible iOS and Android smartphone
* the PI's clinical judgment that it would not be in the adult's best interest to be enrolled
Culturally Adapted Psychoeducation (CaPE) for Bipolar Disorders in Nigeria

Bipolar disorders are chronic mental health disorders that often result in functional impairment, constituting a significant disease burden. It also accounts for seven per cent of disability-adjusted life years caused by mental disorders. Four out of ten persons with a probable diagnosis of bipolar disorders received no mental health care within the preceding twelve months. Compared to the general population, individuals with bipolar disorders tend to have a significantly higher rate of associated suicide mortality. Within the last decade, these mortality rates have substantially increased, suggesting the need for targeted research to address the unresolved needs of individuals suffering from bipolar disorders. A recent meta-analysis found that compared to the general population, bipolar patients had reduced life expectancy with about thirteen years of potential life loss.

Bipolar disorders are historically under-researched compared to other mental health disorders, especially in Sub-Saharan Africa and Nigeria. Our recent study on bipolar disorders in Nigeria provided insight into contextual knowledge and beliefs about bipolar disorders, including the lived experiences of patients with bipolar disorders, their caregivers, and clinicians in Nigeria. The study recommended culturally adapted psychosocial intervention for bipolar patients, hence the proposed research.


Eligibility Criteria:
Inclusion Criteria:

* diagnosis of DSM IV bipolar affective disorder
* currently euthymic (BDI \< 12 and YMRS \< 8)
* age 18-65 years, participants engaged with the mental health services for the preceding 6 months
* able to give written informed consent
* resident of the trial catchment area and
* the ability to speak English.

Exclusion Criteria:

* severe cognitive impairment
* currently experiencing relapse (mania, hypomania, mixed or depressive)
* being actively suicidal
* the presence of any comorbid psychiatric illness such as substance misuse or alcohol dependence according to DSM IV criteria.
Therapeutic Substance Abuse Treatment in Pregnancy - 1

The purpose of this study is... To assess whether a behavioral treatment that combines motivational enhancement and cognitive skills training therapy (MET-CBT) is more effective than brief advice in: 1) decreasing use of a full range of psychoactive substances (e.g. marijuana, cocaine, methamphetamines, alcohol, nicotine, opioids) in pregnant substance using and dependent women; 2) decreasing HIV risk behavior; 3) improving birth outcomes (longer gestations and greater birth weight).

We propose an integrated system of counseling services onsite in primary care obstetrical clinics, comparing a manualized brief advice (closely approximating "treatment as usual") to manualized motivationally enhanced cognitive behavioral therapy. Treatment providers are obstetrical nurses. Therapy patients are taught skill sets designed to enhance motivation to abstain from drugs of abuse, as well as designed to prevent relapse during the perinatal period. It is our hypothesis that therapy patients will be more successful at achieving stated study aims than those receiving brief advice.

Eligibility Criteria:
Inclusion Criteria:

Pregnant women, age 16 or older, alcohol or illicit drug use in the past 30 days -

Exclusion Criteria:

Nonfluent in English or Spanish, pending incarceration, psychotic, cognitively unable to give informed consent, actively suicidal or homicidal, already engaged in addictions treatment, primarily addicted to nicotine or heroin.

-
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation

Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. For this reason, studies in this field are frequent today.

The structural complexities of HLA antigens have been the subject of investigation in recent years. With the development of DNA and RNA amplification methods; It is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. Concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. However, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. In this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to HLA tissue compatibility.


Eligibility Criteria:
Inclusion Criteria:

* patients with liver transplantation and tested for HLA antigen (recipient - donor)

Exclusion Criteria:

* patients who died early Patients whose HLA antigen is not checked