cyrilzakka/clinical-trials huggingface dataset:
Mindfulness and Yoga Therapy for Acute Pain in Sickle Cell Disease

Patients with sickle cell disease suffer from acute and chronic pain that diminishes their quality of life. The purpose of this study is to assess the feasibility and acceptability of mindfulness meditation, breathing exercises, and gentle yoga therapy as supportive measures for the management of acute vaso-occlusive pain crises in the inpatient setting.

This is a prospective single arm study of mindfulness interventions for sickle cell patients admitted with an acute vaso-occlusive pain crisis. Patients will be accrued over a consecutive 12 week period. All genotypes of sickle cell disease will be eligible for enrollment.

After providing informed consent, the patients will have access to 4 videos on their hospital room television. The videos contain guided mindfulness meditation, breathing exercises (including the use of an incentive spirometer), and gentle yoga therapy that can be performed in the supine position from a hospital bed. Videos vary in length from 5-12 minutes. Participants will have the ability to watch the videos as many times as they choose. They may also turn off the video at any time.

The primary outcome is feasibility and acceptability of the intervention. We will record objective data on how many videos are watched by each participant, as well as the percentage of each video completed. We will obtain information about the participants' perception of the intervention through a post-intervention survey and interview.

Eligibility Criteria:
Inclusion criteria:

* Patients with sickle cell disease, any genotype
* Adult patients at least 18 years of age
* English speaking
* Admitted to Clements University Hospital with an acute vaso-occlusive pain crisis

Exclusion criteria:

* Unable to follow simple instructions
* Admitted to the intensive care unit
Titanium Elastic Nailing Versus Hip Spica Cast in Treatment of Femoral Fractures in Children

The purpose of this study is to determine which method is better for treatment of femoral fracture in children in outcomes.

There is no consensus on treatment of closed femoral shaft fractures in children 6-12years old. We aimed to compare hip spica cast with titanium elastic nailing (TEN) in the treatment of femoral shaft fractures in children.

Eligibility Criteria:
Inclusion Criteria:

* patients 6-12 years old with femoral shaft fracture without exclusion criteria

Exclusion Criteria:

* Segmental, Winquist type III and IV comminuted fractures, previously diagnosed neuromuscular disease (e.g., cerebral palsy), metabolic bone disorders (e.g. osteomalacia), or pathological fractures.
Analysis of Factors Related to Occurrence of Serious Adverse Events During Nursing in Intensive Care Units

Patients who are hospitalized in intensive care unit (ICU) require basic nursing care to improve patient hygiene, to promote comfort, to prevent pressure ulcer, and foot or hand's retractations.

Those nursing cares require mobilization very frequently which expose critically ill patients to occurrence of serious adverse events (SAE) such as i) hemodynamic, neurologic, and respiratory variations ii) unplanned dislodgement (lines, drains, catheters, endotracheal tube..)

Few study have evaluated relation between SAE occurence and several patient's, service's, health-care provider's caracteristics. We plan to analyse those factors to find some ways to prevent SAE occurence during nursing and hygiene cares.


Eligibility Criteria:
Inclusion Criteria:

* Health-care affiliated
* Length of ICU stay \< 72 h
* Patient with endotracheal tube
* Patient with tracheostomy
* Patient receiving vasoactives drugs (norepinephrine, epinephrine, Dobutamine)
* Patient undergoing no invasive ventilation during 1hour minimum of 24 hours before the selection
* Patient undergoing hight flow oxygen therapy heated and humidified

Exclusion Criteria:

* Patient already included in this study
* Medical contraindication to the bed bath with lateral mobilization
* Withdrawal of life sustaining treatment
* Spinal trauma
Rapid Acclimatization to Hypoxia at Altitude

In low oxygen environments, such as altitude, some adults may become ill and suffer from acute mountain sickness. Further, all adults will find that exercising becomes much more difficult when compared with exercise at lower altitudes (e.g. sea-level). The purpose of this investigation is to study the effects of two drugs that may help people adjust to high-altitude quickly, prevent them from becoming ill and improve their exercise performance. The drugs are Methazolamide and Aminophylline.


Eligibility Criteria:
Inclusion Criteria:

* normotensive (i.e. \<140/90 mmHg)

Exclusion Criteria:

* Pregnancy
* nursing mother
* current tobacco use or regular use within the previous two years
* use of prescription medication other than birth control
* asthma or any other type of lung/respiratory dysfunction
* resting oxygen saturation \<95%
* unwillingness to abstain from exercise for 48 hours prior to laboratory testing
* use of anticoagulant therapy or have a known or suspected bleeding disorder
* identification of contraindication during screening (i.e. positive stress test)
* any history of mountain sickness (altitude sickness)
* any history of allergic reaction, hypersensitivity or idiosyncratic reaction to any of the products administered during the study, including allergy to any sulfa or sulfonamide derivatives
* history of clinically significant illness within 4 weeks prior to Day 1
* Subjects who have made any significant donation (including plasma) or have had a significant loss of blood within 30 days prior to visit 1
* receipt of a transfusion or any blood products within 30 days prior to visit 1.
Ureteroscopy With and Without Safety Guidewire

The purpose of this study is to investigate the impact of a safety guidewire (SGW) on the results of ureteroscopy for urolithiasis.

Study hypothesis: Routine use of SGW has no impact on the results of ureteroscopic treatment of urolithiasis.

The use of SGW is generally recommended at any ureteroscopic procedure in order to facilitate the introduction of the endoscope and to secure placement of internal tubes for drainage of urine after the procedure.

However, SGW may be an obstacle to efficient disintegration and retraction of calculi in the narrow ureter.

The intention of this study is to compare the results of endoscopic stone treatment with and without the use of SGW.

Eligibility Criteria:
Inclusion Criteria:

* Patients with urolithiasis planned for ureterorenoscopic treatment
Training Programs Effects on Strength and Balance in Older Adults

Ageing involves several physiological changes such as loss of muscle mass, muscle strength, and alteration of balance control mechanisms. Consequently, there is an increased fall risk that can lead the older adult to a reduced self-sufficiency in daily living activities. Investigating the role of different physical activities to counteract the age-related declines deserves attention. The present study aimed to evaluate the effects of two trainings performed with and without unstable devices, on dynamic balance control and lower limb strength compared to a control group that received no intervention.

The a-priori power analysis calculation reported a total sample size of 51 participants. We decided to increase the sample size of approximatively 20% hypothesizing an increment of drop-outs due to the not completely solved COVID-19 pandemic at the time of the study.

In this single-blinded randomized controlled study, both intervention groups received 24 training sessions of 45 minutes each, twice a week for 12 weeks.The two intervention groups and the control group were tested at the baseline (T0), after six weeks (T1), and after twelve weeks (T2).

Subjects of the intervention groups had to complete at least 21 out of 24 training sessions. Moreover, all subjects had to complete all the assessments. Otherwise, they were completely excluded from the data analysis.

Eligibility Criteria:
Inclusion Criteria:

* self-sufficiency in daily living activities;
* aged between 65 and 85 years.

Exclusion Criteria:

* non-corrected sight disorders
* neurological disorders
* regular assumption of drugs that can interfere with normal cognitive functioning
* pathologies that contraindicate physical activity practice
Efficacy and Safety Evaluation of Octreotide in the Treatment of Congenital Hyperinsulinemia

To analyze and evaluate the efficacy and safety of octreotide subcutaneous injection in the treatment of diazazine-ineffective congenital hyperinsulinemia (CHI) in children.

Octreotide subcutaneous injection is effective and safe in the treatment of congenital hyperinsulinemia in children with inefficacy of diazazine.

Eligibility Criteria:
Inclusion Criteria:

1. Consistent with the diagnosis of congenital hyperinsulinemia with ineffective diazine; With the maximum dose of diazine at 15mg/kg/d for 5 days, fasting blood glucose/postprandial blood glucose could not be stabilized at the target value of 3.3mmol/L without intravenous glucose infusion.
2. patients treated with octreotide subcutaneous injection.

Exclusion Criteria:

1. Before the diagnosis of CHI and the treatment related to CHI, the child had received total pancreatectomy without octreotide
2. Secondary hypoglycemia caused by diseases other than CHI
3. Patients who refused to take octreotide due to parents or family economic reasons, but not hospital treatment factors.
4. Patients who intervene/interfere with octreotide treatment regimen for parental reasons
Counseling Intervention on Severe Nomophobia Among Health Care Providers

Assess the effect of a counseling intervention adopted from heath belief model merged with multiple smart phone-based action cues on the level of nomophobia among participants with severe nomophobia Assess the effect of a counseling intervention adopted from heath belief model merged with multiple smart phone-based action cues on the level of nomophobia among participants with severe nomophobia

In this study we seek to find if there is a relation between nomophobia level, self-esteem and mental health status, and discover whether a counseling intervention based on health belief model merged with smart phone-based action cues will decrease the level of nomophobia in participants with severe nomophobia.

through an intervention based on health belief model merged with multiple smart phone action cues employed on the intervention group during 3 counselling sessions

Eligibility Criteria:
Inclusion Criteria:

* Owning and actively using a smartphone.
* Understanding verbal English instructions.
* Willing to participate in a possible counseling session
* physicians currently working in kasr alainy hospital

Exclusion Criteria:

* Having any diagnosed psychiatric disorder.
* Participants taking medications that could affect psychological status e.g: B blockers, mood stabilizers.
The Diagnostic Accuracy of Advanced Imaging in Identifying Suspected Skin Cancer (Basal Cell Carcinoma) Around the Eyes

The purpose is to investigate the diagnostic value (sensitivity and specificity) of dermal-Optical Coherence Tomography (D-OCT, VivoSight Dx), in patients with clinically suspected BCC lesions inside the periocular region and compare these results to previous reports using D-OCT in diagnosing lesions outside the periocular area.

The Hypotheses:

* The sensitivity and specificity of D-OCT in diagnosing BCC inside the periocular region is comparable to previous reports on BCC lesions outside the periocular region when the standard D-OCT probe is used.
* The sensitivity and specificity of D-OCT in diagnosing BCC inside the periocular region is increased when the customised D-OCT probe is used.
* The sensitivity and specificity of D-OCT in diagnosing periocular BCC is comparable to punch biopsy when both standard and the customised D-OCT probes are used.
* D-OCT with the 10 and 20-millimeter standoff is capable of subtyping periocular BCC.
* The inter-observer variation in diagnosing and sub-typing periocular BCC decreases with increasing experience in the scanning procedure.
* The number of scans to correctly interpret D-OCT decreases with increasing experience in the scanning procedure.
* Delineation of periocular BCC tumour extension is possible using both D-OCT probes


Eligibility Criteria:
Inclusion Criteria:

* Clinically suspected periocular BCC.
* Biopsy-verified BCC
* Clinically suspected relapse of periocular BCC
* Age more than 18 years at baseline.
* Legally competent, able to give verbal and written consent
* Communicate in Danish verbally as well as in writing
* Willingness to participate and able to give informed consent and can comply with protocol requirements.

Exclusion Criteria:

* Anatomical circumstances that make OCT-scanning impossible, i.e., extensive scarring of eyelids, or large ulcerating crusts that hampers scanning
* Unwillingness to undergo a skin biopsy or excision of lesion.
* Inability to sign informed consent.
Complications in Adults With Cancer Receiving an Artificial Parenteral Nutrition in the Central Vein

This observational study will evaluate the frequency of complications in adult cancer patients with central venous parenteral nutrition and the identification of aggravating factors.

In oncology, central venous catheters are used for treatments such as chemotherapy, hydration, antibiotic therapy and parenteral nutrition. However, these catheters are responsible for serious complications often infectious or vascular. They can lead to suspension or discontinuation of treatments and can lead to life-threatening outcomes for patients. The incidence rate and risk factors for central venous catheter-related infections in oncology remain poorly known. Recently, a prospective study targeted a 5-fold increase in the risk of catheter infection when parenteral nutrition was associated with chemotherapy.

This is why the indications of parenteral nutrition must be respected and enteral nutrition promoted where possible.

the investigator conducted a retrospective study in 1998 over 10 years and 6 months, including all patients who received or received a parenteral nutrition at home, for at least one month.

Of 153 patients with implantable sites, 181 infectious episodes were recorded in 68 patients (44.4% of the population) with an estimated median infection rate of 2 infections/patients (1-12). There was a clear predominance of community-borne skin germs (85% Staphylococcus sp and 3% multi-resistant bacteria (BMR)).

In order to improve our nursing practices, and reduce complications for patients,the investigator propose the establishment of an observatory of complications in adults with cancer benefiting from superior parenteral nutrition on the central venous tract initiated in hospitalization with a planned return home

Eligibility Criteria:
Inclusion Criteria:

* Central venous parenteral nutrition initiated in hospitalization with a planned return home (with parenteral nutrition).
* Life expectancy \> 3 months
* OMS (World Health Organization) performance status (PS) 0, 1 or 2
* With initial dietary consultation during hospitalization
* Age ≥ 18 years
* Hospitalized 48 hours or more
* Patient Information and Signature of Informed Consent
* patient must be affiliated to a French Social Security System

Exclusion Criteria:

* OMS\> 3 or 4
* Patient in the process of infection
* Patient followed up in surgery
* Patient without central vein
* Patient with superior cave thrombosis,
* Inability to undergo medical follow-up of the trial for geographical, social or psychological reasons,
* Terminally ill palliative patient, excluding surgery.
* Patient whose regular follow-up is not possible due to psychological, family, social or geographical reasons; • Medical or psychological condition which, in the opinion of the investigator, will not allow the patient to complete the study or sign informed consent with full knowledge (Article L.1121-6, L.1121-7, L. 1211-8, L. 1211-9);
Low Cost Interventions to Improve Adherence to Childhood Immunization Schedule

The objective of the study was to assess the effect of 1) redesigned immunization card, 2) center-based education to mothers, and 3) redesigned card with center-based education to mothers, provided at DPT1, on DPT3 completion in a randomized controlled trial at rural Expanded Programme on Immunization (EPI) centers in Karachi, Pakistan.


Eligibility Criteria:
Inclusion Criteria:

* All children visiting the selected EPI centers for DPT1 immunization

Exclusion Criteria:

* Not residing in the same area for last six months.
Tertiary Prevention of Child Sexual Abuse

This is a feasibility study designed to inform the development of a multinational study of the effectiveness of a tertiary prevention program for child sexual abuse. This study targets adult men who have engaged in child sexual abuse, and will be implemented within the Minnesota Department of Corrections. Data will include measures of the implementation process, short-terms changes in criminogenic factors, and staff and participant factors that could influence outcomes.


Eligibility Criteria:
Inclusion Criteria:

* Male
* 18 or older
* Serving time in MnDOC facilities for Criminal Sexual Conduct in the first, second, or third degree, whose victims were less than 14 years old
* Individuals assigned moderate to high risk to reoffend as determined upon entrance to the Minnesota Correctional System by the DOC Risk Assessment/Community Notification Unit."

Exclusion Criteria:

* Diagnosed with an active, uncontrolled major mental disorder (e.g. bi-polar, schizophrenia, schizoaffective disorder, major depression with psychotic features)
* Unable to read English at the 5th grade level
* Unable to speak English
* IQ of less than 85 as measured by standard intelligence tests
* Diagnosis of intellectual disability
* Engaged in violent behavior while incarcerated, as indicated by disciplinary actions and/or segregation within 60 days of intake"
Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis

Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation. At the same time other similar intra-abdominal infections, such as diverticulitis, are treated with antibiotics. There have been some encouraging reports on successful treatment of appendicitis with antibiotics and it has been estimated that operative treatment might be necessary for only 15 - 20 % of patients with acute appendicitis.

The aim of this randomized prospective study is to compare operative treatment (open appendicectomy) with conservative treatment with antibiotics (ertapenem, Invanz). Before randomization acute uncomplicated appendicitis is diagnosed with a CT scan.The hypothesis of the study is that the majority of patients with uncomplicated acute appendicitis can be treated successfully with antibiotics and unnecessary appendicectomies can be avoided.


Eligibility Criteria:
Inclusion Criteria:

* Age range from 18 to 60 years
* CT scan diagnosed uncomplicated acute appendicitis

Exclusion Criteria:

* Age under 18 years or age over 60 years
* Pregnancy or breast-feeding
* Allergy to contrast media or iodine
* Renal insufficiency
* metformin medication (DM)
* Peritonitis (a perforated appendix)
* Lack of co-operation (unable to give consent)
* A severe other medical condition
* CT-scan: other diagnosis, fecal lithiasis in appendix, perforation, abscess, suspicion of a tumour
Protocol to Obtain Blood and Bone Marrow Samples for Myeloma Research

The purpose of this study is to collect a blood or bone marrow sample from patients with multiple myeloma and from volunteers without myeloma.

The blood and bone marrow samples will be used in the laboratory to perform focused studies on multiple myeloma.

Eligibility Criteria:
Inclusion Criteria:

* Participant population is multiple myeloma patients over the age of 18 who are undergoing a scheduled bone marrow collection and/or blood drawing procedure as part of their routine treatment or follow up, and healthy volunteers over the age of 18 who have agreed to have a bone marrow and/or blood harvest as part of a donation to a transplant recipient.

Exclusion Criteria:

* Patients, who in the opinion of their physician, would be adversely affected by removal of an extra15ml of blood and /or an extra 10ml of bone marrow.
Pain Control With Pre-operative Cryoneurolysis Following TKA

The purpose of this study is to assess the potential benefit of preoperative cryoneurolysis in postoperative pain management of total knee arthroplasty patients over current pain management protocol.

Cryoneurolysis, is a novel technique that can yield temporary blockade of superficial sensory nerves, generating immediate and meaningful relief of pain.The technique generates an axonotmesis of the targeted peripheral nerves by percutaneously applying low temperatures (-100 °C to -20 °C). Wallerian degeneration is produced whereby the axons and the myelin sheath are damaged but the endoneurium, perineurium and epineurium remain intact. Therefore, permanent damage to the nerve is avoided as it retains its regenerative properties. With regards to the knee, the infrapatellar branch of the saphenous nerve (IPBSN), a sensory branch serving both the inferior and anterior portion of the knee capsule and the antero-medial skin of the knee is the prime target for the procedure.

Your participation in this study requires that you allow the radiology department of Texas Orthopedic Hospital to administer Cryoneurolysis using the Iovera device with the functional smart tip approximately 1 week prior to total knee arthroplasty surgery. A highly localized cold zone is created via the Joule-Thompson effect as nitrous oxide enters the needles. Nothing is injected into the body and the nitrous oxide gas is vented safely out of the handpiece. Cryoneurolysis is administered following local anesthesia.

Eligibility Criteria:
Inclusion Criteria:

* any patient scheduled for primary total knee arthroplasty(TKA)

Exclusion Criteria:

* Bilateral TKA (patients routinely receive spinal anesthesia)
* Minors
* Patients reporting a history of Raynaud's disease
* Patients with an open and/or infected wound on surgical knee
* Patients who are taking opioids during the pre-operative period due to knee pain
* Patients who cannot return for the cryoneurolysis treatment 7 days prior to surgery or post-operative clinical visits
* Patients whose insurance would deny payment for the cryoneurolysis treatment
* Pregnant patients
* Patients unable to speak and read English
Study of Naproxen Capsules to Treat Dental Pain

The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.


Eligibility Criteria:
Inclusion Criteria:

* Patient is male or female between 18 and 50 years of age
* For women of child-bearing potential: a woman who is not pregnant and not nursing, and who is practicing an acceptable method of birth control
* Patient requires extraction of 2 or more third molars
* Patient must be willing to stay at the study site overnight

Exclusion Criteria:

* Patient has hypersensitivity, allergy, or clinically significant intolerance to any medications to be used in the study, or related drugs
* Patient has a current disease or history of a disease that will impact the study or the patient's well-being
* Patient has used or intends to use any of the medications that are prohibited by the protocol
* Patient has a history of drug or alcohol abuse or dependence, or patient has a positive urine drug screen or alcohol breathalyzer test
* Patient has taken another investigational drug within 30 days prior to screening