cyrilzakka/clinical-trials huggingface dataset:
Different Methods of Forward Head Posture Correction

The goal of the study is to compare various methods of correcting forward head posture in elderly subjects. In particular, we will contrast two methods: the conventional program, which aims to restore muscle balance, and the Chiropractic BioPhysics (CBP) rehabilitation program, which relies on stretching the viscous and plastic elements of the longitudinal ligament and intervertebral disc in addition to effectively stretching the soft tissue throughout the entire body.

Forward head posture has been shown to be a common postural displacement, with a conservative estimate being 66% of the whole population. It is generally believed that this abnormal posture is associated with the development and persistence of many disorders. There are many strategies to treat forward head posture; the commonly used is traditional exercise program, which aims to restore muscle balance by stretching the short muscles and strengthening the weak ones. The second treatment method is Chiropractic BioPhysics (CBP) rehabilitation program which depend on stretching of the viscous and plastic elements of the longitudinal ligament and intervertebral disc, in addition to effectively stretching the soft tissue through the entire neck area in the direction of the normal head and neck postures as seen with Denneroll traction in addition to mirror image exercise. Up to our knowledge, there is no available studies evaluating the difference between the two forward head correcting methods regarding the amount of head posture correction and the impact of different correction methods on balance. Most important, in the majority of the previous studies which investigated the efficacy of the different posture correction techniques, the subjects were young people. Therefore, the results might not be applicable to all age groups, particularly to the elderly, due to age-related musculoskeletal and physiological changes. Accordingly, the aim of this study is to compare between traditional exercise program and chiropractic biophysics approach in elderly subject .

Eligibility Criteria:
Inclusion Criteria:

* craniovertebral angle (CVA) is less than 50°

Exclusion Criteria:

* any signs or symptoms of medical "red flags" were present: tumor, fracture, rheumatoid arthritis, severe osteoporosis, and prolonged steroid use.
* Subjects with previous spine surgery
* Neurological diseases
* Vascular disorders
Galectin-3 in Papillary Thyroid Carcinoma

Thyroid cancer is a common head and neck malignancy. It is the most common endocrine tumor in the body accounting for 1% of all cancers worldwide. The incidence of thyroid cancer varies worldwide. Most countries have reported an upward trend in its incidence.

Thyroid cancer encompass the most common well-differentiated papillary carcinoma (80% of all thyroid cancers) and follicular carcinoma (15%), as well as poorly differentiated carcinoma (\< 1%) and anaplastic carcinoma (\< 2%).

Papillary thyroid carcinomas (PTCs) are the most commonly encountered thyroid malignancies. The diagnosis of PTC is based on the special nuclear features such as overlapping of nuclei, intranuclear inclusions, optical clearing, anisonucleosis and nuclear grooves. However, it is often difficult to differentiate PTC from benign papillary thyroid hyperplasia . As differentiation between benign or malignant thyroid lesions has clinical, therapeutic, and prognostic significance, it is necessary to make accurate diagnosis by using biomarkers.

Recently, a large number of immunohistochemical (IHC) markers have been studied to assist in differentiating non-neoplastic lesions from malignant thyroid lesions. CK19, galectin-3, TG, Ki67, BRAF, calcitonin, HBME-1, TTF-1, and RET are some of the examples of these IHC markers.

Galectin-3 is a 31-kDa β-galactoside binding lectin. It has been shown to be expressed by several types of non-neoplastic and neoplastic cells, and it is involved in cell-cell adhesion and in cell-matrix interactions.


Eligibility Criteria:
Inclusion Criteria:

1. Thyroidectomy specimens both hemithyroidectomy and total thyroidectomy.
2. All the studied cases include sufficient materials for the immunohistochemical study.
3. Complete clinical data

Exclusion Criteria:

1. Patients with recurrence of the primary tumor.
2. Patients with a history of preoperative chemotherapy and/or radiotherapy.
3. Insufficient or tiny tissue biopsies
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Combination of GSK573719 and GW642444 in Subjects With COPD

The study will evaluate safety, tolerability, pharmacokinetics and pharmacodynamics of the combination of inhaled GSK573719 and GW64244 compared to placebo, in subjects with COPD.

This is a multicenter, randomized, double-blind, placebo-controlled, parallel group study to evaluate the safety and tolerability of the combination of GSK573719 (500mcg) Inhalation Powder and GW642444 (25mcg) Inhalation Powder administered once-daily via a novel dry powder inhaler (Novel DPI) over 28 days in subjects with COPD

Eligibility Criteria:
Inclusion Criteria:

* A signed and dated written informed consent prior to study participation
* Males or females of non-childbearing potential
* 40 or more years of age
* COPD diagnosis
* 10 pack-years history or greater of cigarette smoking
* Post-bronchodilator FEV1/FVC ratio of 0.70 or less
* Post-bronchodilator FEV1 of 80% or less of predicted normal

Exclusion Criteria:

* Current diagnosis of asthma
* Other significant respiratory disorders besides COPD, including alpha-1 deficiency
* Previous lung resection surgery
* Significant abnormalities in chest x-ray presentation
* Use of oral steroids, antibiotics or hospitalization for a COPD exacerbation within 3 motnhs prior screening
* Any significant disease that would put subject at risk through study participation
* BMI greater than 35
* Pacemaker
* Significantly abnormal ECG, Holter, or clinical lab finding (including Hepatitis B or C)
* Cancer
* Allergy or hypersensitivity to anticholinergics or inhaler excipients
* Diseases that would contra-indicate the use of anticholinergics
* Use of oral corticosteroids within 6 weeks of screening
* Use of long-acting beta-agonists within 48 hours of screening
* Use of tiotropium within 14 days of screening
* Use of theophyllines or anti-leukotrienes within 48 hours of screening
* Use of short-acting bronchodilators within 4 hours of screening
* Use of investigational medicines within 30 days of screening
* Use of high dose inhaled corticosteroids
* Use of long-term oxygen therapy, CPAP or NIPPV
* Previous use of GSK573719 or GW642444
Electronic Algorithms Based on Host Biomarkers to Manage Febrile Children

Health professionals in developing countries have limited ability to identify children at risk of dying and those in need of antibiotics. The main reasons are limited clinical skills and time, unavailability of diagnostic tests (laboratory or x-ray) and non-adherence to practice guidelines. Child mortality is therefore higher than it should be. Etiological diagnostic tests (detecting microorganisms) may not always help since the distinction between infection and disease and between mild or severe disease is not straightforward. Overprescription of antibiotics is therefore widespread and leads to the development of drug resistance. To address these challenges, decision charts for the management of febrile illness will be developed and include i) few clinical parameters simple to assess, and ii) POCTs results based on specific host markers that can discriminate between mild and severe disease, pneumonia and upper respiratory tract infections, and unspecific fevers of bacterial and of viral origin. This algorithm combining clinical and bedside laboratory tests will be built on an electronic support (android tablet). The first objective of the study is to assess the safety of new electronic decision trees that integrate simple clinical assessment and POCTs results (oxygen saturation and a combination of specific biomarkers of inflammation) as a triage tool to decide on admitting febrile children; the second objective is to assess the usefulness and safety of new electronic decision trees that integrate simple clinical assessment and POCT results (a combination of specific biomarkers of inflammation) as decision-making tool to prescribe antibiotics to non-severe febrile children. The development of such a tool will decrease mortality due to delayed admission, At the same time, it will decrease irrational use of antibiotics, and hence drug pressure and emergence of drug resistance, which represents one of the most important public health threat our world is facing today. This project has the potential of huge applicability since it is specifically designed for end-users with limited medical skills and low resources, as it is the case in most areas of developing countries.


Eligibility Criteria:
Inclusion Criteria:

* Age ≥2 months and \<60 months of age
* Written informed consent from the child's parent or caregiver
* Axillary temperature ≥37.5°C and/or tympanic temperature ≥38.0°C
* History of fever for ≤7 days
* First consultation for the current illness
* Live in the catchment area of the health facility

Exclusion Criteria:

* Age 60 months or greater
* Age less than 2 months
* Weight less than 2.5kg
* Chief health problem is an injury, trauma or acute poisoning
Study of Pitavastatin in Elderly Patients With Primary Hypercholesterolemia or Combined Dyslipidemia

This is an open-label extension study of NK-104-306 (NCT00257686) for elderly patients with hypercholesterolemia or combined dyslipidemia.

This was an open-label study of 60 weeks duration in elderly patients (≥65 years) with primary hypercholesterolemia or combined dyslipidemia who completed the 12 week treatment in study NK-104-306 and who met the inclusion/exclusion criteria. Patients who qualified started open-label treatment with pitavastatin 2 mg QD. The dose of pitavastatin could be increased to 4 mg QD after at least 8 weeks of treatment at 2 mg QD, in patients who failed to attain their LDL-C target.

Eligibility Criteria:
Inclusion Criteria:

* Greater than or equal to 65 years of age
* Primary hypercholesterolemia
* Combined dyslipidemia
* Completed study NK-104-306 (NCT00257686)

Exclusion Criteria:

* Failed to complete study NK-104-306(NCT00257686)
Oesophagectomy and Chest Wall and Respiratory Function

Open surgery for esophageal cancer commonly involves large incisions in the chest, associated with a high rate of pulmonary complications (30-50%). Minimally invasive approach through keyhole surgery has been shown to reduce pulmonary infections by 20%. Enhanced recovery programmes are evidence-based protocols, developed to achieve early recovery after surgery with early mobilisation and chest physiotherapy and have been shown to reduce pulmonary complication rates as well. The investigators intend to objectively measure chest wall movement using 3D motion capture system as well as a wearable measurement system to monitor chest wall movement.

The study population consists of 50 healthy volunteers who have not received upper gastrointestinal surgery and 100 patients treated with surgery more than one year ago (50 open and 50 minimally invasive). Chest wall movement will be measured using a 3D optical motion system and the investigators will establish if inertial measurement units placed strategically on the chest wall are able to quantify chest expansion and lung capacity. Data will be acquired during different breathing patterns and during use of an incentive spirometry. Pulmonary function tests will be undertaken in all patients and the investigators will also collect clinical data concerning health-related quality of life and other concomitant medical conditions. The target outcome of this study is to determine whether the 3D motion capture and wearable systems are reliable in the measurement of chest wall movement after surgical removal of esophagus and the validity and patient acceptability of wearable system, as well as the ability of distinguishing open and minimally invasive surgical approach. A tailored physiotherapy may be developed following this study in order to improve chest wall movement and objectively measure this using the wearable system. This can then be implemented in a clinical trial to provide the evidence base to for patient-tailored physiotherapy following major cancer surgery and to optimise the respiratory function.

Eligibility Criteria:
Inclusion Criteria:

* Exposure group:

  1. Patients treated more than a year ago with oesophagectomy for oesophageal cancer, either by an open approach or minimally invasive surgery.
  2. Patients able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study.
* Control group:

  1. Healthy volunteers with no underlying respiratory disease and no history of upper gastrointestinal surgery.
  2. Individuals able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study.

Exclusion Criteria:

* Any participant who lacks capacity or is unable to provide informed consent.
* Any participant younger than 18 or older than 90 years of age.
* Any patient with evidence of cancer recurrence or on-going postoperative complication at more than one year following surgery for oesophageal cancer.
* Any pregnant participant.
Behavior and Knowledges of Patients Enrolled Into SIOUX Study

The purpose of this study is to contribute to the evaluation of SIOUX study by adding data about the choices of the observant patients, the mis-observant ones or the protocol deviations.

The adherence to treatment for osteoporosis doesn't exceed 50% after one year. The SIOUX project about the inter-professional collaboration (attending physician with dispensary pharmacist) developed therapeutic patient education (TPE) plans and created follow-up booklets which were dealt to the patients who have to transmit it to their two medical professionals twice a year during three years one after one. The results after 18 months are encouraging about the improvement of adherence to treatment and about the lifestyle changes.

Eligibility Criteria:
Inclusion Criteria:

* patients enrolled into SIOUX study

Exclusion Criteria:

* cognitive troubles which prevent the patient to participate in individual interview
Psychometric Properties of the Turkish Version of Young Children's Participation and Environment Measure

The Young Children's Participation and Environment Measure (YC-PEM) is a parent/caregiver reported outcome measure that evaluates the participation status and environmental factors of children under five years old. The aim of this study is to translate the Young Children's Participation and Environment Measure (YC-PEM) into the Turkish language and to investigate the psychometric properties of the Turkish version of YC-PEM in children with typical development and neurodevelopmental disabilities under five years old.

Cross-cultural adaptation Rest-retest reliability Discriminant validity Concurrent validity

Eligibility Criteria:
Inclusion Criteria:

* children under five years
* children with neurodevelopmental disabilities

Exclusion Criteria:

* parents who refused to participate in the study
FirstWIND: Weight Loss Interventions After Delivery

This a pilot intervention study in which postpartum women will be randomized to receive a 6-month postpartum weight loss intervention or usual care.

Overweight and obesity affect over 15 million adult women in the United States. Postpartum weight retention has been shown to be one factor contributing to weight retention, obesity and possible development of type 2 diabetes. African-American women and other minority women are at especially high risk for the development of obesity and type 2 diabetes. We propose to pilot a six-month postpartum-specific lifestyle intervention among urban-based, postpartum African-American women.

Eligibility Criteria:
Inclusion Criteria:

* Postpartum women with a pre-pregnancy or first trimester body mass index of 28 or greater or a history of gestational diabetes in the most recent pregnancy.

Exclusion Criteria:

* Current cardiac disease or serious chronic disease, including cancer.
Risk Factors for Postoperative Shoulder-tip Pain After Laparoscopic Surgery Undergoing General Anesthesia

To find out the risk factors for postoperative shoulder-tip pain after laparoscopic surgery undergoing general anesthesia.

To find out the risk factors for postoperative shoulder-tip pain after laparoscopic surgery undergoing general anesthesia.Besides,this research also aims to observe the incidence of postoperative shoulder-tip pain after laparoscopic surgery undergoing general anesthesia.

Eligibility Criteria:
Inclusion Criteria:

1. Patients over 18 years old (including 18 years old) having gynecologic or gastrointestinal or hepatobiliary surgery undergoing general anesthesia;
2. Patients agreeing to participate in the study and sign the informed consent.

Exclusion Criteria:

1. Patients under 18 years age or having emergency laparoscopic surgery;
2. Patients having laparoscopy but not undergoing general anesthesia;
3. Patients undergoing laparoscopy and having hysteroscopy at the same time.
4. Patients undergoing laparoscopy and having fistulostomy at the same time.
5. Patients having regional thermoperfusion after laparoscopic surgery.
6. Laparoscopy being needed to converse to laparotomy.
7. Patients having shoulder pain or history of periarthritis of shoulder or long-term taking painkillers.
8. Patients having severe psychological problem and unable to cooperate with our study.
9. Patients being sent to ICU for further treatment after operation.
10. Patients being discharged within 2 days after operation and losing contact.
11. Patients having another operation after laparoscopy.
12. Patients taking another painkillers except using patient-controlled intravenous analgesia.
13. Patients refusing to take part in this study.
Stereotactic Precision And Conventional Radiotherapy Evaluation

A randomized phase II study for medically inoperable stage I non-small cell lung cancer where stereotactic body radiotherapy in three fractions to 66 Gy is compared with conventionally fractionated radiotherapy to 70 Gy in 35 fractions.

This is a multicenter Scandinavian randomized phase II study of stereotactic hypofractionated radiotherapy with body frame versus conventionally fractionated radiotherapy for stage I medically inoperable non-small cell lung cancer patients. There is a 1:1 randomization between arm A: Stereotactic radiotherapy to a dose of 66 Gy with 22 Gy per fraction at the isocenter (45 Gy covers the PTV) in 3 fractions during one week with body frame fixation and a planning target volume with a 5 mm margin around the macroscopic tumour, and arm B: Conventionally fractionated radiotherapy to a dose of 70 Gy with 2 Gy per fraction in 35 fractions during 7 weeks with fixation in a vacuum pillow and a planning target volume with a 2 cm margin around the macroscopic tumour.

Eligibility Criteria:
Inclusion Criteria:

* Non-small cell lung cancer stage I: T1-2 N0 M0.
* Medically inoperable patients or patients refusing surgery.
* Morphologically verified. If that is impossible there must be increased tumour size in repeated CT scans and positive PET.
* Patients should have a life expectancy of \> 6 months.
* WHO performance status 0-2.
* Signed written informed consent obtained.
* Patient should be feasible for both study arms.

Exclusion Criteria:

* Patients with central tumour growth adjacent to trachea, main bronchus or esophagus.
* Maximal tumour diameter \> 6 cm.
* Patients with prior malignancy within the last five years (except basal cell carcinoma of the skin or in situ carcinoma of the cervix).
* Any prior antitumoral treatment of the present lung cancer.
* Previous irradiation that included part of the lung.
* Pregnant women.
Mechanistic Interventions and Neuroscience of Dissociation

The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused and non-body focused interventions can change these mechanisms.

People exposed to chronic trauma face devastating effects to the brain and body. Chronically traumatized people become highly distressed when attending to emotional stimuli, which can lead to feelings of detachment from their bodies and environment. It is difficult to engage highly dissociative traumatized patients in trauma-focused treatment; however, these patients benefit from acquiring basic emotion regulation skills, including present-centeredness and body awareness. Various practices that involve present-centeredness and body awareness (including mindfulness-based interventions) have been shown to demonstrate short-term and long-term improvement in cognition, emotion regulation and clinical symptoms in dissociative people with trauma exposure.

In order to address this issue, the researchers will evaluate the effectiveness of interventions that engage present-centered awareness and/or body focus.

Eligibility Criteria:
Inclusion Criteria:

* experience of at least one Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criterion A trauma (assessed using the Life Events Checklist)
* a score of 7 or higher on the Multiscale Dissociation Inventory (MDI) depersonalization subscale
* willingness to participate in the study

Exclusion Criteria:

* actively psychotic and cognitively compromised individuals (assessed using the Moderate-severe cognitive impairment screening tool (MoCA) will be excluded
* moderate or more severe substance dependence (assessed with the MINI)
* persons with imminent risk of physical violence to self or others
Impact of Exercise Training on Endothelial Function in CAD

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

Eligibility Criteria:
Inclusion Criteria:

* stable CAD
* male gender

Exclusion Criteria:

* insulin-dependent diabetes mellitus
* significant valvular heart disease
* smoking
* exercise-induced myocardial ischemia
* conditions prohibiting exercise training