cyrilzakka/clinical-trials huggingface dataset:
Comparison of Two Telemonitoring Auto-titrating Modalities in OSA Patients

This study compares the titration pressures achieved through two auto-titrating modalities, a new incremental fixed pressure mode versus routine auto-adjusting pressure mode, in CPAP-naïve obstructive sleep apnea patients.

The aim of the study is to verify that this new modality achieves a lower titration pressure.

In patients with obstructive sleep apnea (OSA) on CPAP treatment, a CPAP titration test is usually performed to achieve the optimal pressure to maintain upper airway patency, abolish obstructive respiratory events and reduce the occurrence of adverse events. This pressure is called titration pressure.

Until now, we used to perform, after an adaptation period, a single-night outpatient test with an automated device preset on auto-adjusting pressure modality (APAP).

The incremental fixed pressure modality (EZ START) was initially developed to ease patients into having a positive sleep therapy experience from the very beginning. This mode gradually increases air pressure night-by-night until the preset therapeutic pressure is reached. In each good therapy session, the device performs in fixed pressure overnight and we get a real residual apnea-hypopnea index (rAHI).

For this study, we will use the same device (DreamStation auto CPAP, Philips Respironics, Murrysville, PA, USA), a web-based system to telemonitor patient therapy (EncoreAnywhere) and perform for each individual patient the two modalities in a telemonitoring crossover randomized single-blind (patient) way.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-80
* OSA diagnosis
* CPAP therapy indication

Exclusion Criteria:

* Previous CPAP therapy
* Severe COPD
* Respiratory insufficiency
* Obesity-hypoventilation syndrome
* Cardiac failure
* Recent cerebrovascular disease
* Central apnea, Cheyne Stokes or similar
* Important nasal insufficiency or malformation
* Previous pharyngeal surgery
* Shift work
* Psychosocial disability
* Refusal to participate
The Effect of Mobile Online Training Applied to Patients With Diabetes on Insulin Therapy

This study aims to investigate the effect of health belief model-based mobile online training applied to patients with diabetes on insulin therapy.

Intervention and control group participants were invited to the Endocrinology and Metabolic Diseases Outpatient Clinic for a pre-test. n addition, each group was given insulin injection practice training using an insulin injection model. Whether the application was correct, incomplete, or incorrect was recorded on the observation form by the diabetes nurse. The web-based "Insulin Guide" mobile application prepared by the researcher was installed on the phones of the intervention group participants. They were asked to use this application for three months, at least three hours a week. Participants were followed up through the application. Participants who did not use the application were informed by SMS or phone and asked to use the application. Participants who did not use the application were excluded from the study. No intervention was made for the control group participants. At the end of three months, the participants in the intervention and control groups were invited to the Endocrinology and Metabolic Diseases Outpatient Clinic for a post-test. Both groups were asked to practice again on the insulin injection model. Whether the application was correct, incomplete, or incorrect was recorded on the observation form by the diabetes nurse.

Eligibility Criteria:
Research Inclusion Criteria

* Type 1 DM
* Type 2 DM (Diagnosed at least six months ago)
* Patients receiving insulin therapy
* Patients in the 18-65 age group
* Literate patients
* Patients, or patients with a relative, who has an electronic device such as a smartphone, computer, etc. that can connect to the Internet.
* Patients who have no psychiatric illness or communication barrier (visual, auditory, and speech disability)
* Individuals who agreed to participate in the research.

Research Exclusion Criteria

* Patients who receive treatment with oral anti-DM only
* Patients who use an insulin pump
* Patients who quit the training.
* Patients who had a change in treatment
* Patients who traveled to a place that cannot provide an Internet connection
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity

This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding obesity.

The goal of this Research Study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records, particularly regarding obesity.

Eligibility Criteria:
Inclusion Criteria:

1. Signed informed consent by patient
2. Male or female patients age 18 and older.
3. Diagnosis of obesity based on Body Mass Index (BMI) of 30 or greater.

Exclusion Criteria:

1. Refusal by patient to sign informed consent form
2. Treatment with antibiotics within two weeks prior to screening
3. Treatment with probiotics within six weeks prior to screening
4. History of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy
5. Postoperative stoma, ostomy, or ileoanal pouch
6. Participation in any experimental drug protocol within the past 12 weeks
7. Treatment with total parenteral nutrition
8. Any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial
9. Inability of patient to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study
Chronic Shoulder Pain Treated by Pressures With the Thumbs on the Trigger Points

The purpose of this study is to find the efficacy of treating the trigger points located around the shoulder in patients suffering from chronic shoulder pain.

Chronic shoulder pain is a common condition which should be treated by surgery only wen conservative approaches have been tried. in the present trial the authors intend to find the effectiveness of treating the triggers points located in muscles, ligaments and tendons surrounding the shoulderin patients suffering from chronic shoulder pain.

The technique used in this trial is ischemic compression(thumb tip pressure) on the trigger points

Eligibility Criteria:
Inclusion Criteria:

* 30 to 60 years old.
* To have suffered from shoulder pain on a daly basis for at least 3 months
* Participants had to be able to raise the arm above ther head.
* They had accept to receive 15 chiropractic treatments without charge.

Exclusion Criteria:

* Past surgery to the arm.
* Injection to the shoulder in the month preceding the trial.
* A diagnosis of rheumatoid arthritis or any other systemic disorders affecting the joints.
* Shoulder pain from an herniated disc.
Time-of-Day Effects of Fasted Exercise on Energy Intake

This trial's aim is to investigate the time-of-day effects (morning vs. evening) of fasted exercise on acute and 24h post-exercise energy intake. Specifically, we will compare the effects of fasted morning exercise (12h overnight fast) vs. fasted (6h and 12h) evening exercise on total energy intake during a post-exercise ad libitum test meal as well as on 24h (free-living) energy intake. The secondary aim is to assess subjective appetite ratings before, immediately after, and 30 min post-exercise (0-10 Likert scale). Participants (healthy men and women aged 18-30 years) will complete the 3 study conditions in randomized order.

In a three-way crossover design, participants will complete three fasted exercise sessions on a treadmill in randomized order on weekdays with one week in between sessions: once in the morning (\~1h after participants' habitual wake-up time) following a 12h overnight fast (12h AMEx), once in the evening (exactly 12h after the 12h AMEx condition) after a 6h fast (6h PMEx), and once in the evening (identical to the 6h PMEx condition) following a 12h fast (12h PMEx). The last meal before each fasting period will be standardized, providing 25% (meal occurring 12h before exercise) and 30% (meal occurring 6h before exercise, 6h PMEx only) of individual daily energy requirements.

Eligibility Criteria:
Inclusion Criteria:

* BMI of 18.5.0-30.0 kg/m2
* weight stability (≤2.5 kg weight change during the past 3 months)
* ability to exercise at a vigorous intensity for 30 minutes

Exclusion Criteria:

* pregnancy or breastfeeding
* smoking
* history of or current eating disorders
* medical condition or use of medication that could affect appetite or pose any contraindications to exercise

As the menstrual cycle can cause fluctuations in food cravings and appetite, women of childbearing age were only eligible if they used hormonal contraceptives. To ensure constant exposure to exogenous estrogen and progestin throughout the study phase, participating women were further asked to use active hormone pills throughout the study period in both studies, a practice that is considered both safe and efficacious.

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tES With Random Noise Stimulation Applied to Children With Brain Injury

50 children between 4 and 7 years old with moderate to severe motor impairment, 50% males 50% females will participate in an interventional study in two groups: placebo and experimental group.

Placebo group will only receive traditional treatment with physiotherapy and the Experimental or tRNS Group will receive physiotherapy plus tRNS BrainNoninvasive Stimulation.

In this Interventional Study with Double Blind Assignment to Placebo and Experimental Group, Gross Motor Function Measure (GMFM) and Neurophysiological are the parameters measured with EEG amplifier before and after 30 sessions.

Work hypothesis is that the tRNS Group will present better motor functionality after 30 sessions of 30 minutes of duration of electrical brain stimulation administered during physiotherapy exercises 2 days per week than the Group that only receives treatment with physiotherapy during 30 minutes 2 days per week without tRNS.

Eligibility Criteria:
Inclusion Criteria:

* Patients between 3 and 7 years.
* Meet criteria for Congenital or Acquired Brain Injury .
* Patients who have been diagnosed at least 1 year before inclusion in the study.

Exclusion Criteria:

* Acute visual or hearing loss.
* Other neurological disorders: migraine, epilepsy, tuberous sclerosis
* Other neurodevelopmental disorders like ASD, ADHD, PDD, etc ...
A Retrospective Study of Actifuse Synthetic Bone Graft Versus Other Bone Graft Substitutes in Patients Requiring Lumbar Fusion

The purpose of this study is to assess fusion status in patients who underwent spinal fusion with Actifuse synthetic bone graft versus other bone graft material (including autograft) in achieving lumbar spinal fusion.


Eligibility Criteria:
Inclusion Criteria:

* Any patient 18 years of age or older
* Patients with a minimum follow up of 1 year
* Patients who have previously undergone TLIF, PLIF,PLF, XLIF procedures

Exclusion Criteria:

* Patients under the age of 18
* Any patient with less than 1 year of follow up history at the time of first data analysis
* Any patient that the primary investigator deems as an unfit candidate
Development and Clinical Application of [11C]Verapamil-PET

The major hypothesis explaining drug resistance is overexpression of p-glycoprotein at the target lesion. Based on several studies, p-glycoprotein (P-gp) has an important role in neurologic diseases, especially in drug resistant epilepsy. But there is no surrogate marker that can quantify the expression of P-gp because of the difficulty in measuring substances in the neurologic system and the lack of clinical trials. Here, the investigators use a novel non-invasive \[11C\] -verapamil Brain PET and SPAM analytic method as a surrogate marker for quantifying the expression of p-glycoprotein.

A pilot study on healthy volunteers and a case-control study on patients with drug resistant epilepsy and drug sensitive epilepsy is performed. The investigators compare the whole brain SUV in each group (normal control, drug resistant epilepsy, drug sensitive epilepsy) and the asymmetry by the standardized uptake value(SUV) of ipsilateral areas and contralateral areas.

\[11C\] -verapamil PET will be used as a surrogate marker of P-gp expression in patients with epilepsy, and will be an important prognostic factor of individualized drug therapy. Also, it can be used as a biomarker in checking of the drug efficacy of novel medications. Furthermore, by localizing epileptogenic zones for patients, \[11C\] -verapamil PET could contribute in improving the prognosis of surgical treatment in drug resistant epilepsy.

Eligibility Criteria:
Inclusion Criteria:

* Healthy controls ( age range 20-45 years)
* Patient age (\> 15), diagnose as epilepsy

Exclusion Criteria:

* Subjects who take medicines that affect on the function of p-glycoproteins
* Pregnancy or subject who feed the breast milk
* Subjects who had severe renal disease or liver disease
* Subjects who need treated by immunosuppressant or take immunosuppressant
Abdominal CT Combined With AI for Early Screening of Liver Cancer

This study plans to utilize multiphase contrast-enhanced and non-contrast CT（Computed Tomography） images from 10000 pathologically confirmed liver tumor patients at our hospital. An AI（artificial intelligence） model will be used to outline the 3D contours of liver masses, which will then be refined by radiologists and hepatobiliary-pancreatic surgeons to enhance model accuracy. By incorporating more imaging data, the model's recognition capabilities will be improved, laying the groundwork for prospective clinical trials and aiming to establish a superior AI model for early liver cancer screening based on CT imaging.

This research project intends to utilize multiphase contrast-enhanced and non-contrast CT images from 10000 patients with a full spectrum of liver tumors (such as HCC（hepatocellular carcinoma）, ICC（intrahepatic cholangiocarcinoma ）, META（Metastasis）, etc.), confirmed by the pathological gold standard at our hospital. Through a pre-established AI model, the 3D contours of various liver masses will be delineated. In collaboration with senior physicians from our hospital's radiology department and hepatobiliary pancreatic surgery department, the AI-drawn contours will be refined to obtain more accurate 3D mass models, thereby enhancing the validation efficacy of the model. By incorporating more radiological data, the precision of the model will be improved, boosting its recognition capabilities and laying a solid foundation for subsequent prospective clinical trials. The ultimate goal is to establish a superior AI model for early screening of liver cancer based on CTimaging.

Eligibility Criteria:
Inclusion Criteria:

* From 2019 to 2030, our hospital has collected non-contrast and contrast-enhanced CT images from patients with a full spectrum of liver tumors (such as HCC, ICC, META, etc.), all confirmed by the pathological gold standard

Exclusion Criteria:

* Patients who have undergone upper abdominal surgery. Examples include post-ERCP (Endoscopic Retrograde Cholangiopancreatography) for the pancreas, post-external drainage surgery, esophageal surgery, and gastrectomy, among others.
* Patients who have received systemic treatments such as chemotherapy or traditional Chinese medicine. Examples include chemotherapy for lymphoma, chemotherapy for leukemia, chemotherapy for lung cancer, and comprehensive treatment for liver cancer, etc.
* Patients with poor-quality CT images. Examples include convolution artifacts caused by the inability to place hands on the sides of the body and respiratory artifacts due to poor breath-holding, etc.
Quarantine and Telerehabilitation in Chronic Pain Patients During COVID-19 Pandemic.

The quarantine during COVID-19 pandemic has changed daily routine. Staying at home for prolonged periods of time can pose a significant challenge for patients with chronic pain. The purpose of the current study is to investigate how the quarantine effects of psychosocial factors, quality of life, sleep, nutrition and physical activity in patients with chronic musculoskeletal pain. Another purpose is to examine whether a telerehabilitation exercise program is effective during the lockdown period.

Participants, both male and female, with chronic musculoskeletal pain for at least 3 months will be included in the study. They will complete some questions about anxiety, depression, sleep, nutrition, quality of life, pain behavior and characteristics, illness perceptions, functioning and daily routine. Questionnaires will be completed twice (first and last week of quarantine, 40 days of duration). A group of patients will follow an exercise program during this time. It will be evaluated the link between the question of physical and psychological factors in the experience of pain in quarantine situation and, also, it will examine whether a telerehabilitation exercise program is effective during the lockdown period.

Eligibility Criteria:
Inclusion Criteria:

* Patient with chronic musculoskeletal pain (Chronic pain will be defined as pain lasting for 3 or more months. Also, pain intensity will be at least 3 on a 0-10 numerical pain rating scale on most days of the last 3 months).
* Patient with sufficient understanding of the Greek language

Exclusion Criteria:

* Patients without being at quarantine
* Systemic diseases such as rheumatoid arthritis, fibromyalgia and/or polymyalgia rheumatic
* Osteoporosis, haemophilia and/or cancer
* Recent surgery or trauma
* Being pregnant or given birth in the preceding year
* Cognitive impairment
* Inability to provide informed consent and/or complete written questionnaires
Cystoealstometer (Bladder Monitor Device)-Home Use

The investigators have developed a novel pressure monitoring device called a 'cystoelastometer' that connects to a drainage end ofastandard urinary catheters that are used by patients with a neurogenic bladder on daily clean intermittent catheterization. The device has already been demonstrated to be accurate in measuring bladder pressure compared to the gold standard urodynamics that are performed in the clinic or hospital. This study will assess the patients and care givers ability and experience using the cystoelastometer device in a home setting.

: For patients with neurogenic bladder, regular monitoring of bladder pressure and capacity is a critical component of maintaining renal and urinary health. This monitoring is currently done by in-office urodynamics testing (UDS). This testing is done intermittently, leaving open the possibility of worsening of bladder function and renal deterioration between testing sessions.

This study utilizes a novel pressure and bladder volume monitoring device which is portable and attaches to the end of a standard urinary catheter and measures the pressure in the device and then assists in the drainage of the bladder and records the bladder volume. The investigators will be investigating if this device can be used by patients or their caregivers in a home setting.

This study will enroll patients with neurogenic bladder that currently perform clean intermittent catheterization on a daily basis as part of their regular care. The patients will be asked to use the device at least twice a day for two weeks.

Eligibility Criteria:
Inclusion Criteria:

* Patients seen in the University of Iowa Pediatric Urology Clinic with neurogenic bladder managed with clean intermittent catheterization.
* Patients who haven't had any change in management
* Patients who had recently had UDS (urodynamic study) performed

Exclusion Criteria:

* phone which is not iOS compatible
Investigation of the Acute Effects of Percussive Massage Treatment and Stretching Exercise on Balance and Performance

In this study, it was aimed to investigate the acute effects of Percussion Massage Therapy and stretching exercises on balance, horizontal jumping and performance in healthy individuals. It was planned to include 45 individuals in the study. Participants will be randomly divided into 3 groups. Horizontal jumping distance, T-Drill test and balance assessment will be done for all participants. After the evaluation, percussion massage therapy will be given to the 1st group, dynamic stretching exercises to the 2nd group, and static stretching exercises to the 3rd group. All measurements will be repeated after the intervention.

48 healthy individuals meeting the inclusion criteria of Istanbul Medipol University will be included in the study. Individuals who are at a level to perform performance tests, who have not undergone orthopedic surgery in any of their regions, who do not have problems in running and during sudden turns, and who do not have a professional sports background will be included in the study. Individuals with a history of trauma, anatomical deformities and skeletal system fractures, diagnosed orthopedic or rheumatological diseases, being included in the physiotherapy program in the last 6 months, and those with pain in any region will be excluded from the study. Before the study, demographic information, horizontal jump test, T-Test and Fizyosoft balance system will be evaluated with both feet and one foot with eyes open and closed. After the evaluation, percussion massage therapy will be given to the 1st group, dynamic stretching exercises to the 2nd group, and static stretching exercises to the 3rd group. All measurements will be repeated after the intervention.

Eligibility Criteria:
Inclusion Criteria:

* Capable of performing performance tests
* Those who have not undergone orthopedic surgery in any region
* Having no problems during running and sudden turns
* Individuals who do not have a professional sports background

Exclusion Criteria:

* Trauma history
* Anatomical deformities and skeletal system fractures
* Diagnosed orthopedic or rheumatological diseases
* Being included in a physiotherapy program in the last 6 months
* Individuals with pain in any part of the study
Does Menopause Matter?

The purpose of this study is to follow a woman's progression through menopause in order to examine the effects on health related quality of life and use of health care resources, and to understand how women are using alternative therapies.

Menopause affects every woman as she ages, yet every woman's experience is different. We are seeking to enroll 720 women from the University of Pittsburgh's Division of General Internal Medicine Outpatient practice (GIMO) at all stages of menopause (pre-, peri-, and post-menopausal), between 40 and 65 years old. They will be followed for 5 years as they progress through menopause.

Women will complete yearly questionnaires during their usual doctor's visit (or by phone or online if necessary) regarding general health, menopause and menopausal symptoms, health related quality of life, traditional and alternative therapy use, social support, and attitudes towards menopause and aging.

We will combine this information with information from women's medical charts to look at how menopause and health related quality of life impact the use of health care resources. Additionally, some women may be asked about the use of health care resources, such as doctor's visits, hospitalizations and lab tests.

Eligibility Criteria:
Inclusion Criteria:

* Women ages 40-65
* Patients in the University of Pittsburgh General Internal Medicine Oakland Practice
* Able to complete the Functional Assessment Screening Tablet (a touch-screen survey)

Exclusion Criteria:

* Refusal to participate