cyrilzakka/clinical-trials huggingface dataset:
Prehospital Screening to Prevent Injury and Illness

The goal of this project is to prevent injuries and diseases among older adults through the development and evaluation of a novel emergency medical services (EMS)-based screening program to identify preventable injuries and diseases and refer the identified injuries and diseases for intervention.

To prevent injuries and diseases among older adults, this study specifically aims to:

1. Evaluate the feasibility of an EMS-based primary prevention program that screens older adults for need of the influenza and pneumococcal vaccine and for risk of falling during emergency medical responses in a rural setting;
2. Evaluate the outcome of the EMT-implemented screening and education program by performing a 14-day telephone follow-up on older adults cared for by EMTs.

At the conclusion of this award, we will determine if an EMT-implemented primary prevention program for older adults is feasible and benefits the community.


Eligibility Criteria:
Inclusion Criteria:

* Age 65 or older;
* Request assistance from intervention group EMS agency
* Request assistance from control group EMS agency
* Request assistance between February 2003 and June 2005

Exclusion Criteria:

* Institutionalized
* Previous inclusion in study
* Unable to communicate in English
Nocturnal Cyclic Enteral Nutrition Infusion Versus Continuous Infusion of Enteral Nutrition

Enteral nutrition is considered the best way to feed those who can´t be fed orally. the standard protocol of administration includes continuous infusion for 24 hours; nonetheless this support is constantly suspended which causes a decrease in the nutrition administered vs the one formulated.

Therefore this randomized clinical trial attempts to compare de standard administration vs. cyclic infusion during night hours measuring the formulated vs the administered volume of enteral nutrition given to the patient.

The control group will be assigned standard 24 hour infusion of enteral nutrition while the experimental group will be assigned cyclic infusion during night hours. The variables include volume formulated, volume given in 24 hours, hours and reasons why the enteral nutrition was suspended, and related complications (abdominal distension, vomiting, and diarrhea).

The trial will be carried at San Ignacio University Hospital intensive care unit. Patients included will be over 18 years old who require enteral nutrition according to their attending or to the nutritional and metabolic support team.

260 envelopes with the specific intervention were created. 130 of them are identified with number 0 which corresponds to no intervention, meaning continuous enteral nutrition infusion during 24 hours. The other 130 are assigned with the number 1 which corresponds to intervention, meaning nocturnal cyclic nocturnal enteral nutrition infusion.

Envelopes will be randomly assigned sequentially from number 1 to 260, in which envelope number 1 will be assigned for the first patient. Each patient´s envelope will be labeled with its name and identification number. According to the information contained in the envelope the specific scheme assigned will be formulated.

Envelopes will be kept at the Nutritional and metabolic support´s office; only research assistant will have access to this information.

After 50% of the sample be achieved, there will be a data analysis to review the rate of intolerance to enteral nutrition in both groups.

Principal investigators will review the entire data after completion of the clinical trial, measuring percentage of enteral nutrition delivered and intolerance to enteral nutrition feeding.

Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years old, hospitalized in San Ignacio University Hospital intensive care unit.
* Patients with indication on enteral nutrition defined by its attending or by the Nutritional and Metabolic support team.

Exclusion Criteria:

-If patient or legal advocate denies to sign consent to participate in this study.
F@ce 2.0 - Information and Communication Technology-based Rehabilitation Intervention After Stroke in Sweden

The purpose of the present proposal is to implement and evaluate a new model for mobile phone supported and family-centred rehabilitation intervention (F@ce 2.0) with regard to functioning in activities in daily living and participation in everyday life among persons with stroke and their families in rural and urban areas in Sweden.

The investigators' previous feasibility study suggested beneficial effects on occupational performance and satisfaction of a mobile phone supported and person-centred rehabilitation intervention (F@ce1.0) after stroke in Stockholm, Sweden. The purpose of the present proposal is to implement and evaluate F@ce 2.0 on functioning in activities in daily living (ADL) and participation in everyday life among persons with stroke and their significant others (someone identified by the person with stroke as close i.e.partner, friend, son, daughter).

With recommendations on evaluation of complex interventions both outcomes and processes will be studied and hence both quantitative and qualitative methods will be applied. In a randomized controlled trial F@ce 2.0 will be evaluated compared to ordinary rehabilitation in urban/rural Sweden regarding; self-efficacy, perceived performance and participation in everyday activities, independence in ADL, health care utilization and the families´ perceived participation in everyday activities. Qualitative data will explore experiences of people with stroke, significant others and rehabilitation staff of participating in F@ce 2.0. The research project has a multidisciplinary perspective for sustainable rehabilitation interventions, a prerequisite for better participation in everyday life for people with stroke.

Eligibility Criteria:
Inclusion Criteria:

* Persons who have had a stroke
* Enrolled in one of the participating home rehabilitation teams in Stockholm and Dalarna
* Able to participate in eight weeks of intervention

Exclusion Criteria:

* Inability to formulate activity goals
* Inability to express themselves in Swedish
Ultrasound Needle Transducer for Regional Anesthesia Validation Study

To validate the efficacy of miniaturized ultrasound needle transducer as the primary guide for thoracic regional anesthesia.

Paravertebral (PVB) and intercostal nerve block (ICNB) are both techniques of injecting local anesthetics for pain management at thoracic and upper abdominal region.

Today, PVB and ICNB are performed under the guidance of surface two dimensional B-mode ultrasound. However, the procedure still carries potential risks for inexperienced operators since the target zone is very close (2-3 mm) to the pleura. In certain patients, such as those with obesity, the steep needle trajectory and poor quality of the anatomic image make the nerve block even more difficult.

Inaccurate identification of the anatomical structures or suboptimal positioning of the needle tip could result in complications and blockade failure.

We designed an intra-needle ultrasound (INUS) system to improve the identification of anatomical structures and needle tip position. The system passed all safety standards including electrical safety test, biocompatibility test, software certification.

This study is to investigate the feasibility and image quality of INUS during ICNB and PVB. The study protocol is approved and under monitoring for safety and compliance from both Institutional Review Board of Taipei Veterans General Hospital and Ministry of Health and Welfare, Taiwan, Republic of China.

Eligibility Criteria:
Inclusion Criteria:

1. Patients scheduled for elective thoracic surgery
2. Patients scheduled for elective upper abdominal surgery
3. Patients scheduled for elective breast surgeries.

Exclusion Criteria:

1. Known coagulopathies,
2. Skin lesion or infection at site of nerve block
3. Pregnant women
4. Allergic to local anesthetics
5. Cognitive diseases
6. Unstable hemodynamics
7. Chronic substance abuse (ex. alcohol, hypnotics, opioids)
Comparative Effects of Dual Task Training and Embodied Learning on Dual Task Performance in Children With Down Syndrome

Down Syndrome is Caused by an extra copy of chromosome 21, characterized by impaired motor skills, especially difficulties with coordination, and cognitive impairment. Improving these abilities is essential to raising the affected children's quality of life and everyday functioning. Dual task learning and embodied learning stand out among other interventions as effective strategies. While embodied learning uses physical motions to support cognitive growth, dual task learning mixes motor and cognitive tasks concurrently, testing the brain's capacity for multitasking. The purpose of this study is to compare how well embodied learning and dual task training work to improve dual task performance in kids with Down syndrome.

This study contains 22 participants age 7 to12 years and excludes participants with other neurological or orthopedic disorders, is focused on individuals who match the inclusion criteria Children that are being able to follow instructions. The Participants will be Referred by Allama Iqbal School Sialkot and Children Hospital Sialkot. To test changes in motor coordination and balance, assessment tools such as the Pediatric Balance Scale (PBS), timed Up and Go Test, Single Leg Stance Test, Four Stage Balance Test, and 30-second Sit to Stand Test will be used. In order to evaluate cognitive engagement and the development of motor skills, dual task training setups (such as walking while labelling objects or balancing while solving puzzles) as well as embodied learning activities (such as Gesture-Based Learning, Physical Storytelling, Yoga, and Sensory Play Art) will be used. The purpose of this research is to offer useful knowledge about the effectiveness and practicality of various interventions in improving the everyday functioning and quality of life of children with Down syndrome.


Eligibility Criteria:
Inclusion Criteria:

* Children diagnosed with Down Syndrome
* Age 7 to 12 years
* Ability to follow instructions effectively

Exclusion Criteria:

* Neurological conditions (cerebral palsy or epilepsy)
* Orthopedic conditions (Foot Abnormalities,s Hip Dysplasia)
* Significant sensory impairments (e.g., severe hearing or vision impairments.
Methadone Anesthesia For Kidney Transplant Receptors

Intraoperative methadone or fentanyl will be administered to patients submitted to kidney transplant surgery. Postoperative pain, analgesic consumption and side effects will be evaluated

Despite recent developments in postoperative pain control, many patients still experience moderate or severe pain after surgery. It is estimated that severe postoperative pain occurs in 20 to 40% of surgical procedures. With the development of kidney transplant services, a better study of the intraoperative analgesia used in this procedure and its impact on the postoperative is necessary. The management of postoperative pain in renal transplant recipients is essential to improve the quality of postoperative care, and may even impact the prognosis of the renal graft. One of the strategies to improve pain control in the perioperative period is the intraoperative use of intravenous methadone, given its pharmacokinetic profile. Methadone is an opioid agonist of µ receptors, it is also a Glutamate antagonist by blocking the N-methyl-D-aspartate (NMDA) receptor, and inhibits the reuptake of serotonin and norepinephrine. When administered in doses of 20 to 30mg, the analgesia generated by methadone can last from 24 to 36 hours. There is also evidence that the use of methadone in doses of 0.2 to 0.3 mg / kg is not associated with a higher incidence of side effects when compared to other opioids with short or intermediate duration of action, such as fentanyl, sufentanil and morphine. The aim of this study is to evaluate the effectiveness of using intraoperative methadone to reduce postoperative pain in patients undergoing kidney transplant surgery (recipients). Patients will be submitted to standardized general anesthesia, and the opioid used in anesthetic induction will be methadone or fentanyl with additional boluses if necessary. After extubation, Fentanyl will be installed in an intravenous analgesia pump controlled by the patient. Differences between groups regarding opioid consumption, pain scores, side effects and patient satisfaction will be assessed

Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years of age
* With indication for kidney transplant surgery
* Who sign the informed consent form

Exclusion Criteria:

* Patients who refuse to participate in the study
* Known allergy to any drug used in this protocol
* Presence of stage III or IV congestive heart failure
* Increase in QT interval on electrocardiogram (QT\> 500 msec)
* Preemptive kidney transplantation (defined by transplantation in a patient who has not yet started kidney replacement therapy).
BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories

The purpose of this study is to test the effect of ibuprofen on the levels of a number of different proteins (called biomarkers) in cerebrospinal fluid (CSF), blood, and urine to see whether ibuprofen can influence certain biomarkers associated with the progression of Alzheimer's Disease.

The hypothesis to be tested is that the possible role of ibuprofen in preventing AD can be detected in changes in biomarkers of AD.

Eligible participants will complete an enrollment visit to include: a physical exam, a neurological exam, neuropsychological testing, and a minor blood draw. At the second visit, approximately 2 weeks later, participants will undergo a baseline lumbar puncture, and will be issued either ibuprofen or placebo to take once daily for 6-12 weeks. Both the participants and the clinicians will be masked to treatment assignment. After 6-12 weeks, the participants will undergo a second, and final, lumbar puncture. This will complete participant involvement in the study.

Eligibility Criteria:
Inclusion Criteria:

* Age 59 years or older at time of the first visit
* Family history of one or more first-degree relatives with Alzheimer-like dementia
* Fluency in written and spoken English
* Willingness to limit use of Vitamin E (\<600 IU per day), Non-aspirin NSAIDs, Aspirin (\<81mg per day), Histamine H2 receptor antagonists, and Gingko biloba extract for the duration of the study
* Ability and intention to participate in regular study visits
* Provision of informed consent

Exclusion Criteria:

* History of peptic ulcer disease complicated by perforation, hemorrhage or obstruction
* History of uncomplicated peptic ulcer with symptoms in the 28 days prior to the first visit
* Clinically significant hypertension, anemia, liver disease, or kidney disease
* Hypersensitivity to aspirin or other NSAIDS
* Concurrent use of warfarin, ticlopidine, or any other type of anti-coagulant
* Concurrent use of systemic corticosteroids
* Use of ≥ 4 doses per week of either of the following in the 14 days prior to the first visit: Non-aspirin NSAIDs, Aspirin (\>81mg per day), or Histamine H2 receptor antagonists
* Current plasma creatinine ≥1.5mg/dL
* Enrollment in any trial that is likely to interfere with BONSAI procedures or affect treatment outcomes
* Cognitive impairment or dementia
Descriptive Study of Emergency Room Visits From Nursing Home Residents for Behavioral Problems at the Nancy University Hospital: Place of the Advanced Practice Nurse

The demographic evolution of old age is a reality. After the age of 75, 2 out of 3 people living in institutions have neurocognitive disorders. Behavioural disorders such as physical aggression, agitation, hallucinations, sleep disorders, generate difficulties in the management of these patients and lead to unscheduled emergency hospitalizations. Non-pharmacological management of behavioral disorders is recommended as a first-line treatment because of its low risk and potential improvement (Haute Autorité de Santé 2009). However, this management is not simple and obvious to put in place, especially since not all elderly people with Behavioural disorders are in adapted structures. The advanced practice nurse specializing in geriatrics has a place in this care pathway. Because of her skills, she could "organize multi-professional care, set up analyses of practices within the nursing homes, train caregivers appropriately, and limit hospitalizations due to behavioral problems" (SALIEGE L. 2020). Advanced practice nursing is in its infancy in France, and everything remains to be done (International Council of Nurses- directive). The aim of the study is to identify the number of emergency room visits by people aged 75 and over for behavioral problems in nursing home during a 6 month-period.


Eligibility Criteria:
Inclusion Criteria:

* Person who has received full information on the organization of the research and has not objected to the use of this data
* Elderly men and women 75 years of age and older at the time of the emergency room visit
* Having for main residence one of the nursing homes of the Grand Nancy
* Administratively present in the emergency department
* Having been admitted to the emergency room for the following reasons:

  * Behavioural problems
  * Agitation
  * Dementia
  * Disorientation
  * Delirium

Exclusion Criteria:

* People under 75 years of age
* Residing at home or in a senior residence or in a nursing home outside Grand Nancy
* Referred by an inpatient department (rehabilitation department)
* Other reasons for emergency room use such as "depression" and "apathy
Heat Shock Proteins: a Pathogenic Driver and Potential Therapeutic Target in Acute Pancreatitis

To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.

Eligibility Criteria:
Inclusion Criteria:

* no prior diagnosis of acute pancreatitis
* admission to the hospital within 2 days since the clinical symptoms
* confirmed diagnosis of acute pancreatitis

Exclusion Criteria:

* chronic pancreatitis
* pancreatic cancer
Usefulness and Acceptability of a Connected Ergocycle for the Elderly in a Clinical Setting

Hospitalizations are harmful to patients. Without a proper intervention, it will lead to a permanent decline in physical function, especially among frail individuals. Ultimately, this will worsen quality of life, as well as the cognitive and functional status of affected elderly people, which will arguably reduce functional independence, increase post-discharge institutionalization and death among frail older adults. It is known that patients receiving early physical evaluation and rehabilitation (in the 24 hours following admission) improves post-discharge orientation, decreases delirium and the need of acute care. The rehabilitation often involves ergocycles, but commercially available devices are expensive and often hard to move, to set up in hospital bed and lack connectivity.

In this context, a connected ergocycle prototype which has a number of desired characteristics, including low production cost, relatively light and easy to move and with internet connectivity. The goal of this study is thereby to assess the usefulness and acceptability of the prototype with health professionals involved in physical rehabilitation and patients receiving said rehabilitation.


Eligibility Criteria:
Inclusion Criteria :

* \> 55 years old
* receiving treatments for terminal renal insufficiency at least 3 times a week, for at least 3 months (hemodialysis; HD) or under mechanical ventilation for less than 72 hours, and that should last for at least 24 more hours (intensive unit care; ICU)
* Physically independent outside HD or before admission (ICU) (≥ 70 on the Barthel index)
* with medical clearance (HD : nephrologist; ICU : intensivist)

Exclusion Criteria:

* unable to walk without assistance (before ICU admission)
* diagnosed neurocognitive decline
* recent hemiarthroplasty for a hip fracture that causes a limitation in the flexion of the hip during pedaling
* already involved in another study

Exclusion Criteria Specific for ICU Patients :

* neuromuscular disorder affecting the weaning from mechanical ventilator support
* pathologic fracture or unstable cervical spine fracture
* hospitalized for more than 7 days
* COVID-19 positive
* reported as moribund by the intensivist
Comparison of Technology-assisted and Face-to-face Assessment in Patients With Low Back Pain

Although the concepts of telemedicine and tele-rehabilitation have been frequently emphasized in recent years, the evaluation part remains inadequate. There is no study investigating remote technology-based balance, mobility and strength assessments in patients with low back pain. Therefore, the aim of the study is; It is the examination of face-to-face and technology-based remote balance, mobility and strength assessment in patients with low back pain.


Eligibility Criteria:
Inclusion criteria

* Those over the age of 18
* People who can read and write
* Patients who have not undergone surgery
* Those whose body mass index is less than 30 m2/kg
* Volunteering to participate in the study

Exclusion criteria

* Patients who underwent surgery due to disc herniation
* Having any spinal pathology
* Having an uncontrolled neurological and metabolic disease
* Having a spinal deformity such as scoliosis or kyphosis
* Those with serious orthopedic, vascular, neurological or psychiatric problems that affect balance