cyrilzakka/clinical-trials huggingface dataset:
Hypercoagulability and Thromboembolic Risk in Patients With Malignant Disease, Evaluated by Thrombelastograph (TEG®)

Patients with malignancies are at high risk of developing a thromboembolic complication and their treatment with chemo- and or radiation therapy further enhances this risk.

Conventional haemostatic tests are not suitable as a screening tool of a hypercoagulable state. A hypercoagulable profile identified with the whole blood Thrombelastograph (TEG) Analyzer parameter maximal amplitude (MA) is reported to correlate with thrombotic events in patients undergoing major non-cardial surgery and recurrent ischemic events in patients undergoing percutaneous coronary intervention.

In this study we investigate the correlation between TEG measurements and thromboembolic events in patients with newly diagnosed malignancies.

The hypotheses of this study are:

1. Patients with malignancies and hypercoagulability, defined as a TEG MA\>69 mm and /or R\<4 min is at increased risk of developing thromboembolic complications as compared to those with a MA\<69 mm and/or a R\>4 min.
2. Hypercoagulability and hence TEG R and MA values are affected by the treatment instituted in these patients (chemo and radiation therapy) rendering the patients more hypercoagulable and hence at increased risk of developing thrombotic complications.


Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of cancer

Exclusion Criteria:

* Mamma cancer
Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation

The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in patients with incomplete Spinal Cord Injury.

The long-term objective of this study is to optimize the rehabilitative potential in spinal cord injury (SCI) by maximally harnessing the potential available for functional neural plasticity. SCI is an important cause of serious, long-term disability in young adults. This fact, further complicated by rising disability-related costs, makes SCI a significant economic and social burden. Upper limb dysfunction is one of the most prevalent and debilitating impairments. More than 75% of patients with quadriplegia (paralysis of all 4 limbs following spinal cord injury in neck and upper back) prioritize return of upper limb function over any other lost function. Alleviating deficits of the upper limb may represent a cost-effective stategy to reducing the burden of SCI.

Although various exercise programs and neuromuscular stimulation methods have been employed to mitigate functional impairments of the arm and hand, success of these modalities is still debated. Evidence for efficacy of rehabilitation is inconclusive as outcomes are variable, confounded by methodological issues, and have shown poor generalizability. It is now speculated that limited succcess of rehabilitation emerges from inability of current methods to adequately harness the potential for significant neuroplasticity available in SCI.

Even though the site of damage in SCI does not involve the brain, the neural networks in the brain that control movement of the arm and hand are markedly affected. These regions lose their territory that the investigators argue could hamper effects of upper limb therapy. The Investigators objective is to directly modulate adaptive plasticity in these regions of the brain to enhance function of the upper limb in iSCI. The Investigators central hypothesis is that noninvasive brain stimulation, called transcranial direct current stimulation (tDCS), when delivered concurrently with rehabilitation will generate synergistic functional advantage. Adaptive plasticty would be obeserved as changes in structure of pathways emerging from the brain and the individual's function.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosed with incomplete spinal cord injury (iSCI) that occurred at least 6 months ago

Exclusion Criteria:

* History of epilepsy in a first degree relative
* Use of anticonvulsants
* Pregnant
* Implanted pumps, shunts, or neurostimulators
* Neurologic condition affecting sensorimotor systems
* Brain tumor
* Dementia
* Substance abuse
* Stroke
* Damaged skin on the scalp
* Concurrent upper limb rehabilitation
Relationship Between Auto NRT and Behavioural T & C Levels With the Nucleus Freedom Cochlear Implant

Cochlear implants require programming on an individual basis to provide appropriate levels of electrical stimulation. This program, or "map", is placed in the speech processor of the cochlear implant. Success of implantation largely depends on the adequacy of this map. Cochlear implant fitting remains a difficult challenge in congenitally or pre-linguistically deafened children. It requires competence of experienced audiologists with expertise in behavioral techniques for hearing function assessment.Our goal is to establish the offset correlation between objective measurements (NRT and ESRT) and the behavioral measurements of T \& Cs in different stimulation rates in the Freedom SP System.

An open trail. The implantees will go through their routine programming sessions after implantation, the specified data will be collected and analyzed in order to establish the offset correlation which we seek for.

Eligibility Criteria:
Inclusion Criteria:Patients eligible for the study should be capable of providing reliable subjective counted thresholds (e.g. children older than 12 years of age at CI or adults) and has good NRT recordings, implanted with the Nucleus Freedom system

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Exclusion Criteria:Implantees With any other serious illness, Who can not give a reliable subjective counted thresholds

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30Gy Versus 40Gy Involved-field Radiotherapy for Localized Diffuse Large B Cell Lymphoma Achieving CR After Chemotherapy

The purpose of this study is to determine whether 30Gy Involved-field Radiotherapy (IFRT) is as effective as 40Gy in the treatment of localized Diffused Large B cell Lymphoma (DLBCL) when completing CR after chemotherapy.

The best proper doses of IFRT in combined modality treatments (CMT) for localized DLBCL is still undetermined. Existing treatment guidelines recommend 40Gy or above as the standard treatment dosage. However, there were large-scaled clinical trials implying smaller doses such as 30Gy may be equivalent effective. Lowering radiation doses can decrease treatment toxicities and radiotherapy-induced diseases, which has been conformed by HD13 study for Hodgkin's Lymphoma. It may even retain the truth when modern era radiation techniques are involved and especially in patients achieving CR after chemotherapy. A comprehensive, prospective dose-comparing study is needed.

Eligibility Criteria:
Inclusion Criteria:

* biopsy-proved Diffuse Large B cell lymphoma
* nonbulky stage I, nonbulky stage IE, nonbulky stage II, or nonbulky stage IIE disease(Bulky disease was defined as a mass 10 cm or more in maximal diameter) according to Ann Arbor Staging
* provide written informed consent
* Complete regression after chemotherapy
* Considerable to CT simulation and 3D CRT or IMRT
* Performance status 0-2 WHO criteria；life expectation\>6 months
* negative for human immunodeficiency virus syndrome (HIV)
* Minimal staging included chest radiograph, computed tomography of the abdomen and pelvis, and single percutaneous bone marrow biopsy and blood studies

Exclusion Criteria:

* primary mediastinal large B cell lymphoma
* dermatological lymphoma
* testicular lymphoma
* primary central nerve system lymphoma
* prior RT
* history of low-grade lymphoma congestive
* history of heart failure (CHF; New York Heart Association \[NYHA\] classifications III-IV), history of neoplasm (adequately treated basal cell carcinoma of the skin or in situ carcinoma of the uterine cervix were allowed), abnormal liver function tests (aminotransferases and alkaline phosphatase \> 2.5 times the upper limit of normal, bilirubin \> 50 ), renal insufficiency (serum creatinine \> 300 ), and patients with any serious medical or psychiatric illness that would prevent informed consent or completion of protocol-prescribed treatment and follow-up
Effectiveness of Pilates and Taping in Office Workers With Neck Pain

The aim of this study is to investigate the effectiveness of pilates and kinesiotape applications in office workers with neck pain. In this direction, neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life will be evaluated.

The aim of this randomized controlled experimental study was to investigate the effectiveness of Pilates and kinesiotape in office workers with neck pain. In this study where a total of 42 office workers will be followed for 8 weeks, individuals will be randomly divided into two groups. The training groups will consist of 3 people each. The control group will receive only Pilates training and the experimental group will receive kinesio taping in addition to Pilates training. Individuals will be analyzed for neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life.

Eligibility Criteria:
Inclusion Criteria:

* Have been office workers for at least 1 year
* Using a computer at a desk for at least 3 hours a day
* Having neck pain for more than 6 weeks
* Having neck pain rated at or above 3/10 on a visual analog scale

Exclusion Criteria:

* Having neurological and rheumatologic chronic diseases
* Having received physical therapy in the last 6 months
* Having a history of trauma to the spine
* Having a history of surgery in the cervical spine
* Having diagnosed cervical/lumbar disc and spine pathologies
* Having an allergic reaction to taping
The Iron and Muscle Study

This is a multi-center randomized controlled trial that will examine the efficacy of IV iron supplementation when compared to placebo, with and without exercise training, on changes in patient exercise capacity. The study aims to provide sufficient data to inform a power calculation for the definitive study to examine whether IV iron therapy in patients with CKD stages 3-4 (non-dialysis) can improve exercise capacity, muscle metabolism and physical function. Specifically, we propose to examine whether a strategy of IV iron therapy in patients with stages 3-4 CKD who are iron-deficient but NOT anaemic leads to improvements in exercise capacity.

Very little is currently known about the effects of iron deficiency on cardiac or skeletal muscle metabolism in patients suffering from CKD. Nevertheless, it seems likely that iron deficiency will contribute to mitochondrial dysfunction and reduced energy production in cardiac or skeletal muscle of CKD patients, and importantly may contribute to the reduced exercise capacity, physical function and overwhelming fatigue commonly reported in this population. The results of this trial will provide data to ascertain whether intravenous iron therapy might be beneficial to exercise capacity, muscle metabolism, physical function, and fatigue and whether iron repletion enhances the effect of an exercise intervention.


Eligibility Criteria:
Inclusion Criteria:

* Patients with established CKD (Stages 3-4) not on dialysis
* Resting BP ≤ 160/95mmHg
* Men and women aged 18 - 80 years
* Serum ferritin level less than 100μg/L AND/OR transferrin saturation ≤20%
* Haemoglobin 110 - 150 g/L

Exclusion Criteria:

* Pregnancy or breast feeding (Female patients of childbearing age will be asked if there is any possibility they may be pregnant. This is standard of care and no pregnancy test will be requested unless there is doubt about this. IV iron is given to many pregnant patients in standard treatment and there is no evidence of harm to mother or foetus).
* Weight \< 50kg
* Known allergy to iron therapy
* Haemochromatosis, porphyria cutanea tarda or history of acquired iron overload
* Intravenous iron within previous 6 weeks
* CRP \> 50 mg/L
* Serum phosphate \< 0.7 mmol/L.
* Active infection
* Current therapy with ESAs
* Uncontrolled atrial fibrillation
* Use of anticoagulants in those under consideration for muscle biopsy
* Unstable angina or heart attack within the last year
* Presence of solid organ cancer
* Known haemoglobinopathy, myelodysplasia, or myeloma
* Patients with peripheral vascular or musculoskeletal disease, who the investigator deems unable to carry out the 6MWT.
* Known severe aortic stenosis and pacemaker in-situ
* History of severe atopy
* Severe liver disease with serum transaminases \> x3 upper limit of normal range according to local laboratory values.
* Severe lung disease with FEV1 known to be \<50% predicted in last year
* Known heart failure with a left ventricular ejection fraction \<45% in last year
* Any other health condition considered by the local Principal Investigator in which IV iron will be contraindicated.
* Insufficient understanding of the trial
mHealth for Phosphorus Management in CKD.

The project aims to generate an mHealth environment in which CKD patients are empowered in terms of the self-management of their hyperphosphatemia pathology, while under medical supervision. Such environment will allow nephrologists to inform patients beyond their traditional point-of-care and will allow patients to provide feedback on their condition in a timely manner that benefits the CKD collective. In this way we delve in a technological area that has been argued that remains underutilized within nephrology (1) and that should be perceived as an opportunity for CKD (2). In our work, we will build from recent related efforts in the control of hyperphosphatemia (3).

The working hypotheses are listed as follows:

1. Hyperphosphatemia is an important problem in the CKD realm, but difficult to manage because patients are often not aware of its importance. In addition, current clinical practice does not allow nephrologists to evaluate the patient's real understanding of their recommendations.
2. The patient could benefit from a smartphone-based interactive virtual assistant tool: an integrated personalized management system to achieve a form of participatory, personalized, predictive and preventive medicine in the specific domain of a pathology associated to CKD.
3. The combination of a flexible information channel with an interactive data visualization tool on mobile devices can be a most intuitive way to communicate with the patient, particularly if it allows comparison with other patients in similar situation. Additionally, data visualization can assist nephrologists in the clinical management of patients.

Primary Objective:

1-Analysis of the superiority of a Medical Mobile Application for Patient Support to educate CKD patients on how to self-manage their phosphate levels versus standard of care in lowering serum phosphorus by assessing changes in serum phosphorus comparing baseline with 6-months follow-up.

Secondary Objectives:

1. Adherence to treatment with phosphate binders.
2. Impact in Quality of Life of patients with CKD.
3. Satisfaction of such a tool.

Eligibility Criteria:
Inclusion Criteria:

1- Eligible patients will be stage 4-5 CKD patients, including end-stage renal disease (ESRD) on dialysis, aged \>18 with hyperphosphatemia (serum phosphorus concentration \>1.94 mmol/L) and stable dose of phosphate binders for \>1 month before screening.

Exclusion Criteria:

1. Patients with intact parathyroid hormone concentration \>800 ng/l (88 pmol/l) or if parathyroidectomy will be planned or expected.
2. Patients with significant gastro-intestinal (GI) or hepatic disorders.
3. Patients with major GI surgery.
Pulse Oximeter Hypoxia

The aim of this project is to test the accuracy of pulse oximeters (devices intended to measure oxygen saturation in blood noninvasively) during mild, moderate and severe hypoxia (a lower-than-normal concentration of oxygen in arterial blood); ie, a range of arterial HbO2 saturations from 100 to down to 70%. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxyhemoglobin (hemoglobin carrying oxygen) saturation, that is arterial blood sample processed in a laboratory.


Eligibility Criteria:
Inclusion Criteria:

1. The subject is male or female, aged ≥18 and \<50.
2. The subject is in good general health with no evidence of any medical problems.
3. The subject is fluent in both written and spoken English.
4. The subject has provided informed consent and is willing to comply with the study procedures.

Exclusion Criteria:

1. The subject is obese (BMI\>30).
2. The subject has a known history of heart disease, lung disease, kidney or liver disease.
3. Diagnosis of asthma, sleep apnea, or use of CPAP.
4. Subject has diabetes.
5. Subject has a clotting disorder.
6. The subject a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.
7. The subject has any other serious systemic illness.
8. The subject is a current smoker.
9. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.
10. The subject has a history of fainting or vasovagal response.
11. The subject has a history of sensitivity to local anesthesia.
12. The subject has a diagnosis of Raynaud's disease.
13. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
14. The subject is pregnant, lactating or trying to get pregnant.
15. The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.
16. The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.
Efficacy of Loteprednol Ointment Following Eyelid Surgery

Inflammation occurs after any type of incisional surgery. This study will evaluate the efficacy of Loteprednol etabonate ointment vs. Soothe ointment (vehicle) for postoperative inflammation after routine eyelid surgery.

Eyelid surgery such as blepharoplasty is often performed for functional and cosmetic indications. Following any incisional surgery, postoperative inflammation occurs at the surgical site. This study will evaluate the efficacy of reducing postoperative inflammation after bilateral eyelid surgery using Loteprednol etabonate (steroid) vs. Soothe ointment (vehicle of Loteprednol etabonate). Common postoperative changes at the incision include: erythema, thickening/elevation of the skin, pigmentary changes and pain. The use of a topically applied steroid would be expected to reduce inflammation and this study will evaluate this. For each patient, one eyelid will be randomly chosen to treat with medication and the other eyelid will be treated with vehicle ointment and by using the same patient, each patient will be internally controlled. Antibiotic prophylaxis is often given after eyelid surgery and this will be used in all patients in the study.

Eligibility Criteria:
Inclusion Criteria:

* Age \> 18 years old
* Scheduled for bilateral eyelid surgery
* Willing and able to return for all study visits
* Willing and able to administer treatments as required
* Understand and sign informed consent approved by UCSD institutional review board

Exclusion Criteria:

* History of allergy to investigational drug (Loteprednol etabonate) or ingredient in drug including petrolatum
* History of collagen vascular disease and receiving concurrent treatment that could interfere with interpretation of study results
* Concurrent ocular therapy with nonsteroidal anti-inflammatory drugs, mast cell stabilizers, antihistamines, decongestants, immunosuppresants, and systemic or ocular corticosteroids
* History of immunodeficiency
* Prior eyelid or facial surgery
* Prior ocular or orbital trauma
* History of ocular hypertension, steroid responder, or glaucoma
* Pregnancy or lactation
* Uncontrolled systemic disease or significant illness
* Any other condition the investigator believe would pose a significant hazard to the subject if the investigational therapy were initiated
Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure

Acute hypoxemic respiratory failure (AHRF) is a common cause of admission in intensive care units (ICUs) worldwide. We will assess machine learning (ML) techniques for prediction of prolonged duration (\> or = to 7 days) of mechanical ventilation (MV) in 1,241 patients enrolled in the PANDORA study in Spain. The study was registered with ClinalTrials.gov (NCT03145974). Our aim is to identify a model with the minimum number of variables that predict duration of prolonged ventilation in AHRF patients using data as early as from the first 48 hours with machine learning algorithms.

Acute hypoxemic respiratory failure (AHRF) is the most common cause of admission in intensive care units (ICUs) worldwide. The investigators will assess the value of machine learning (ML) techniques for prediction of prolonged duration (\> or equeal to 7 days) of mechanical ventilation (MV) in 1,241 patients enrolled in the PANDORA study in Spain. Few studies have investigated the prediction of prolonged MV in patients with AHRF.

For model training and testing, the investigators will extract data from random pateints from the first 2 days after diagnosis of AHRF. The investigators had a database with 2,000,000 anonymized and dissociated demographics and clinically relevant data from 1,241 patients with AHRF from 22 hospitals in Spain. The investigators will follow the TRIPOD guidelines for prediction models. The investigators will screen relevant collected variables using a genetic algorithm variable selection to achieve parsimony. We will use 5-fold corss-validation in the data set of patients with data at T0, T24 and T48. We will use 25% of patients randomly selected for evaluation of the model.

Eligibility Criteria:
Inclusion Criteria:

* enotracheal intubation puls mechanical ventilation
* PaO2/FiO2 ratio \<or = 300 mmHg under MV with PEEP \>or =5 and FiO2 \>or = 0.3

Exclusion Criteria:

* Brain death patients
Anatomic Characteristics of Lisfranc Ligament in Vietnamese Adult

Goal: the aim of this study is to determine the anatomic characteristic of lisfranc ligament

Goal: the aim of this study is to determine the anatomic characteristic of lisfranc ligament, including components, thickness, height, and width, origins as well as relationship of center point of origin with neighbor structures in Vietnamese adults

Eligibility Criteria:
Inclusion Criteria:

* above ankle amputation samples at Cho Ray hospital, HCM city, Vietnam

Exclusion Criteria:

* foot injuries
* foot infection
Improving Identification of Mental Health/Substance Use Disorders in HIV Primary Care: Pilot Clinical Response

This research is a feasibility pilot of an intervention to respond to positive screening tests for mental health(MH) and substance use (SU) captured through the Patient Reported Outcomes questionnaires (PROs). The PROs are currently performed in the clinic, however, the results are neither reviewed with patients nor transmitted to providers. This pilot assesses the feasibility of moving the PROs into the clinical realm by having patients review the PRO results, identifying an issue to discuss at the patient's next HIV primary care visit, and determining whether this process increases discussion of MH and SU disorders in the subsequent clinical visit and/or increases referrals to MH and/or SU treatment.


Eligibility Criteria:
Inclusion Criteria:

* must be enrolled in the Johns Hopkins Clinical Cohort at the Johns Hopkins Moore Clinic
* must be living with HIV

Exclusion Criteria:

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