cyrilzakka/clinical-trials huggingface dataset:
Examination of Fibrillation Atria Using Magnetic Resonance Imaging and Endocardial High-density Mapping

Cather ablation of non-paroxysmal atrial fibrillation is less effective compared to paroxysmal atrial fibrillation. Therefore, new techniques have been developed, such as high-density mapping to determine areas of focal and rotational activities. The aim is to assess the clinical efficacy of ablation focal and rotational activities, and to assess the relation between the areas of focal and rotational activities with fibrosis of both atria assessed using magnetic resonance.

Pateints with non-paroxysmal atrial fibrillation will be enrolled. Before the procedure, cardiac magnetic resonance will be done to determine the extent and location of atrial fibrosis of both atria using dedicated software. The procedure itself will be done standardly, in alangosedation, from both femoral veins, using 10-pole catheter in the coronary sinus, intracardiac echocardiography, and two transseptal punctures by means of SL1 sheaths. Octarey mapping catheter (Biosense Webster, USA) wil be inserted in the left atrium, and during ongoing atrial fibrillation, a maping of left atrium will be done to locate the areas of focal and rotational activities. Afterthat, using Smart Touch ablation catheter (Biosense Webster, USA), pulmonary vein isolation will be done. When PVI is achieved, all areas of focal and rotational activities determined by high-density mapping will be performed. If sinus rhythm is achieved, the procedure is finished. If atrial fibrilaltion is organized to regular atrial, this regular tachacardia is mapped, ablated and the procedure is finished. If atrial fibrilaltion continues, mapping of the righ atrium using the same technique is done followed by catheter ablation of areas of focal and rotational activities. If atrial fibrillation is still present after all these ablation, electrical cardioversion will be done.

Patients will be discharged on following day. 5-day Holter recording will be done in 3, 6, and 12 months during standard out-patient controls.

The aim is to compare the findings of high-density mapping with findings on atrial MRI (relation between fibrosis on MRI and locations of rotational and focal activities). Furher aim is to assess the efficaccy of this kidn of ablation, i.e. the sinus rhythm maintenance in 3,6, and 12 months.

Eligibility Criteria:
Inclusion Criteria:

* non-paroxysmal atrial fibrillation

Exclusion Criteria:

* creatinine \> 120 umol/l
* claustrofobia
* pregnancy
* mechanical valve
* significant valve disease
* left ventricular dysfunction, EF less than 35%
Observational Safety Study in Subjects Using Levemir® (Insulin Detemir) for the Treatment of Type 2 Diabetes Mellitus

This study is conducted in Asia. The aim of this observational study is to evaluate the incidence of serious adverse drug reactions while using insulin detemir under normal clinical practice conditions in the Gulf countries


Eligibility Criteria:
Inclusion Criteria:

* After the physician decision has been made to use insulin detemir therapy, any subject with Type 2 diabetes is eligible for the study, including newly-diagnosed subjects who have never received insulin or an insulin analogue before. The selection of the subjects will be at the discretion of the individual physician

Exclusion Criteria:

* Subjects who are unlikely to comply with protocol, e.g. uncooperative attitude, inability to return for the final visit;
* Subjects currently being treated with insulin detemir;
* Subjects who previously enrolled in this study or studies related to NovoMix 30;
* Subjects with a hypersensitivity to insulin detemir or to any of the excipients;
* Women who are pregnant, breast feeding or have the intention of becoming pregnant within next 8 months.
Recurrence Risk Evaluation by 21-gene Detection

Breast cancer patients with early breast cancer were enrolled according to the inclusion criteria. Baseline characteristics were recorded from medical record system. Recurrence score were obtained by 21-gene detection kits from different biological companies. Relationship between recurrence score and the prognosis was explored. Meanwhile, the investigators analyzed the consistency of the results obtained from various 21-gene test kits and immunohistochemistry detection.


Eligibility Criteria:
Inclusion Criteria:

1. breast cancer in stage I-III, tumor size\>0.5cm
2. lymph nodes negative
3. hormone receptor positive （ER+/PR+,ER+/PR-,ER-/PR+）
4. HER2 negative（IHC 0 or +， FISH negative）
5. receive endocrine therapy only
6. enough FFPE samples within 10 years（3\~6 10μm ）
7. patients with integrated medical records

Exclusion Criteria:

1. Tumor cells \<5%
2. Isolated RNA\<500ng
Impact of Mulligan Squeeze Technique on Meniscal Derangement in Knee Osteoarthritis Patients

The objective of this study is to find out the effects of Mulligan's Squeeze technique added as a complementary treatment to the conventional physiotherapy for the management of meniscal derangement in knee osteoarthritis patients.

This study was performed to determine the consequences of conventional physical therapy with and without Mulligan's Squeeze technique for meniscal derangement treatment in patients with knee osteoarthritis. This research study was a randomized controlled trial. The sample size was of 26 subjects. The subjects were nominated in accordance to the inclusion and exclusion criteria. They were equally and randomly divided into two groups. One group received Mulligan's Squeeze technique along with conventional physiotherapy exercises, with hot pack prior to the exercise session. The control group was only given conventional therapy exercises with hot pack application prior to any exercise. The treatment was given for two weeks and a total of six sessions, three sessions each week. The primary outcome measures were Numerical Pain Rating Scale (NPRS) for pain rating and goniometer to record range of knee flexion. The secondary outcome measures were Patient-specific functional scale (PSFS) and Knee-injury osteoarthritis outcome score (KOOS). The measurements were taken at baseline, at end of first week and after the second week. The data was analyzed by using IBM SPSS software version 27.

Eligibility Criteria:
Inclusion Criteria:

* • Pain during maximal knee flexion, pain when maximal extension of knee occurs

  * Both genders were taken; male and female
  * Age between 30 to 55 years
  * Tenderness along the line of joint
  * Complain or history of abnormal clicking sounds and/or popping of knee
  * If any of the mentioned special tests are positive: "Apley's compression and distraction test", the "Disco test or Thessaly's test" with almost 20° flexed position of knee, and "McMurray's test"
  * Participants who were willing to take part in the study

Exclusion Criteria:

* • Presence of any knee co-morbidities

  * Knee OA of Grade 4
  * ACL or some other knee ligament injury/tears
  * Contusion present on knee, fracture of knee
  * Knee dislocation
  * Knee instability due to any ligamentous injury
  * Constant pain or discomfort due to underlying reasons (e.g. hyper-algesia), and any other wound or ailment
  * Participant not willing to be a part of the study
Evaluating the Therapeutic Effect of Acupuncture on Acute Ischemic Stroke Patients

The investigators design a randomized, single blinded, control study to evaluate the therapeutic effect of acupuncture in acute ischemic stroke patients:

Acupuncture therapy in traditional Chinese medicine has been verified in many disease by thousands years. Due to the feasible and relatively safe in acupuncture management, now the west countries had been well document about acupuncture in medicine. The acupuncture therapy applied in post stroke functional recovery has been considered as more benefit than physical therapy only to post stroke rehabilitation. However, the effect of combined acupuncture therapy with standard management in acute stroke patient still remains unknown. The aim of this study is to evaluate the therapeutic effect of acupuncture in acute ischemic stroke patients. The prospective study was designed as a randomized, single blinded, control trial. We collected newly onset of acute ischemic stroke patient without underling systemic major illness, and randomized assign the collected patients into two groups as experimental (acupuncture)group and normal control group. The two groups both treat with routine western medicine as standard stroke therapy. The outcome measurement will evaluate by the changes from baseline at one and three months. The assessed scales including NIH stroke scale, the Barthel index, the Functional Independence Measure score, the Fugl-Meyer Assessment, and the Modified Rankin Scale. We compared the all variable measurements to see if any benefit from acupuncture group than the control group.

Eligibility Criteria:
Inclusion Criteria:

* newly onset of acute ischemic stroke,Exclusion Criteria:
* without underling systemic major illness
Sickle Cell Disease: Targeting Alloantibody Formation Reduction; Risk Factors, and Genetics

The focus of the study is the pathophysiological mechanism of allo-antibody formation after red blood cell transfusion in sickle cell disease patients.

The main objectives of this study are to study the role of the innate and adaptive immune response in allo-antibody formation and furthermore to identify the genetic and time dependent clinical risk factors on alloimmunization in SCD patients.

Subjects without allo-antibodies, receiving a red blood cell transfusion, will be included in this study. At 5 time points blood will be drawn from these subjects. (T0: Before transfusion, T1: 1 day after transfusion, T2: 1 week after transfusion, T3: 4 weeks after transfusion, T4: 6 months after transfusion).

At each time point specific markers of the immune system will be measured.

Eligibility Criteria:
Inclusion Criteria:

* Sickle cell disease
* Receiving a red blood cell transfusion

Exclusion Criteria:

* Previous positive screen for allo-antibodies
* \>25 red blood cell units in the past
Electronic Deprescribing Tool for the Prevention of PIP

This study is a cluster randomized control trial aimed to measure the effectiveness of an educational knowledge transfer intervention to prescribers on the discontinuation of two targeted classes: Benzodiazepines andNon-benzodiazepine hypnotics.

The investigators intend to develop an electronic decision support tool based on the best evidence available. This electronic deprescribing tool provides the rationale on the indications of prescribing or deprescribing Benzodiazepines or/and Non-benzodiazepine hypnotics and also provides interactive tapering suggestion integrated on a calendar. It is designed to help family doctors with the goal of improving health outcomes for the elderly.

Eligibility Criteria:
Inclusion Criteria:

* patients ≥65 years who have been taking Benzodiazepines or/and Non-benzodiazepine hypnotics for at least 3 months and who do not meet any exclusion criterion

Exclusion Criteria:

* incapacity or unwillingness to provide written informed consent. Patient with dementia, psychotic disorder, a severe personality disorder; institutionalization; terminal illness, seizure disorders, rapid eye movement sleep disorders, benzodiazepine withdrawal, ethanol withdrawal, severe generalized anxiety disorder, epilepsy and periprocedural anesthesia
Palladium-103 Seed Implant and Single Daily Dosing of Uroxatral Vs. Twice Daily Dosing of Flomax- A 3 Month Retrospective Efficacy Analysis

In the past ten years, newer drugs with more selective affinity for the alpha-receptor have been introduced. Alfuzosin (Uroxatral) and Tamulosin(Flomax are two second generation alpha-blockers. In the course of our clinical proctice, both drugs have been used routinely. This retrospective comparison is intended to be a priliminary comparison of their effectiveness and side effects.


Eligibility Criteria:
Inclusion Criteria:

* Males age 45-80 years
* Diagnosis of prostate cancer
* Status post IMRT and Palladium-103 seed implantation and initiated alpha blocker therapy with alfuzosin10mg daily or tamulosin 0.4mg bid at time of seed implantation
* Baseline AUA score\< or =12
* May be on antiandrogenand/or alpha reductase therapy
* Patients receiving IMRT followed by Palladium-103 Brachytherapy implantation as the primary therapy for prostate cancer with curatives intent -

Exclusion Criteria:

* History of insulin-dependent diabetes
* Uncontrolled hypertention
* History of symptomtic hypotension (including syncope and dizziness)
* Pre-existing obstructive uropathy based on history of BPH and or Acute Urinary Retention
* Pre-existing prostatitis either continuous or intermittent
* Concurrent use of any other anticholinergics
* previous or concurrent usage of LHRH agonist
Study to Evaluate Properties of Radiprodil Given in Oral Solution to Healthy Volunteers

To evaluate the pharmacokinetics (PK) profile of Radiprodil in suspension form in healthy adult subjects.

UP0027 is a Phase 1, single-center, open-label study to investigate the safety, tolerability, and PK profile of radiprodil in healthy adult male and female subjects after a single fasting oral dose of radiprodil 30 mg suspension formulation. A total of 10 subjects will be enrolled in the study.

The primary objective of the study is to evaluate the PK profile of oral radiprodil in suspension form in healthy adult subjects.

The secondary objective of the study is to evaluate the safety and tolerability of oral radiprodil in suspension form in healthy adult subjects.

The exploratory objectives of the study are to evaluate the comparative PK profile of radiprodil from samples collected using 2 alternative microsampling techniques (MITRA™ and Drummond capillary tubes) with that of conventional venous blood samples, and to test the perception of the taste and texture of the oral radiprodil suspension.

Eligibility Criteria:
Inclusion Criteria:

* Subject is male or female, ≥ 18 years to ≤ 45 years of age
* Subject smokes \< 10 cigarettes per day and has a score of \< 4 on the Fagerström Test for Nicotine Dependence (Heatherthon et al., 1991). The Fagerström Test is not required for nonsmokers (ie, no smoking for at least 6 months)
* Subject has a body mass index (BMI) of 18 to 30 kg/m² (inclusive), with a body weight of at least 50 kg (male) or 45 kg (female)
* Subject has a blood pressure and pulse rate within the normal range in supine position after 5 minutes rest (systolic blood pressure: 90 mmHg to 140 mm Hg, diastolic blood pressure: 45 mmHg to 90 mmHg, pulse rate: 45 bpm to 90 bpm)

Exclusion Criteria:

* Subject has a known hypersensitivity to any components of Radiprodil liquid formulation including the excipients or a history of drug or other allergy that, in the opinion of the Investigator or UCB Study Physician, contraindicates his/her participation
* Subject has received prescription or nonprescription medicines (including over-the-counter medicines and herbal and dietary supplements \[including St John's Wort\]) within 14 days. Exceptions:

  * Paracetamol for the treatment of mild symptoms (eg, headache or other pain), given at most every 6 h to 8 h, not exceeding 2 g/day, and with a total of no more than 5 g over 7 days
  * Inhaled corticosteroids for seasonal rhinitis
  * Vitamins within recommended daily dose Limits
* Subject has consumed any grapefruit, grapefruit juice, grapefruit-containing products, or star fruit within 14 days prior to administration of Radiprodil
* Subject has a history of unexplained syncope or a family history of sudden death due to long QT syndrome
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing

The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.

Mechanical ventilation is among the most common interventions in the intensive care unit (ICU). Over the last two decades, numerous studies have investigated methods to improve outcomes of patients receiving mechanical ventilation. Despite this proliferation of data, a large, multi-national cohort study found clinical outcomes such as duration of ventilation and ICU stay have not improved significantly between1998 to 2004.

It is recommended that weaning should be considered as early as possible in the patient trajectory and spontaneous breathing trials (SBT) attempted, as SBT are the best diagnostic criteria to determine extubation readiness. The decision of ready to extubate is considered complex because both delayed and failed extubations are associated with increased ventilator time and increased mortality. It is shown that dyspnea occurs among nearly half of ventilator patients and is strongly associated with anxiety and delayed extubation. Between 30-75% of ICU patients report anxiety where dyspnea, impaired communication skills, and sleep disturbances may be predisposing factors. The assessments of work of breathing and clinical deterioration are important sub-categories in clinical judgment for determining weaning tolerance.

There is little evidence whether the patients experiences of work of breathing is correlating with physicians and nurses. Hence, we suggest the need to evaluate the interobserver agreement for clinical assessment in weaning.

The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.

Eligibility Criteria:
Inclusion Criteria:

* Patients using artificial airway (intubation and / or tracheostomy)
* Duration of mechanical ventilation longer than 24 hours
* weaning from mechanical ventilation
* 18 years of age or older
* Motor Activity Assessment Scale (MAAS) 3-4

Exclusion Criteria:

* less than 18 years of age
* insufficient command of the language spoken in the study center
* serious brain damage
* withdrawal of consent at any stage of the research
THE IMPACT OF COVID-19 AMONG OBESE PATIENTS

BACKGROUND: Stay-at-home orders in response to the Coronavirus 2 (SARSCoV-2) have forced abrupt changes to daily routines.

The aim of our study is to evaluate the impact of the Stay-at-home orders on the waiting list for bariatric surgery in our Department of Medical and Surgical during covid-19 pandemic.

MATERIALS AND METHODS: In this observational retrospective study, from the 9th of March to 18th May 2020, the patients of our Department were invited to answer to a 14-questions multiple-choice questionnaire relative to weight changes, working activity, daily exercise, dietary behaviors, and conditions potentially impacting the nutritional choices


Eligibility Criteria:
Inclusion Criteria:

- Alle obese patients on the waiting list for bariatric surgery in our Department of Medical and Surgical during covid-19 pandemic from March to May 2020

Exclusion Criteria:

- Patients underwent bariatric surgery
Validity and Reliability of the Scapular Muscular Endurance Test

The scapula plays a crucial role in proper shoulder function, contributing to synchronized scapular rotation during humeral motion, serving as a stable base for rotator cuff activation, and acting as a key link in the kinetic chain. Each of these functions is essential for optimal arm movement and depends on the integrity of the surrounding shoulder anatomy. However, bone and soft tissue damage, as well as muscle weakness and shortening, can alter the scapula's roles, affecting both its resting position and dynamic motion. This altered scapular position and/or motion is referred to as scapular dyskinesia.

Although scapular dyskinesia is commonly observed in shoulder injuries, it is generally considered a nonspecific response to shoulder pain rather than a direct consequence of a specific glenohumeral pathology. Therefore, assessing the presence or absence of scapular dyskinesia is a critical component of clinical evaluation. A comprehensive assessment should include a visual examination of the scapula at rest and during dynamic humeral movements, as well as objective measurements of posture and the performance of scapular corrective maneuvers. These evaluations assist clinicians in determining the extent to which scapular involvement contributes to a given shoulder injury.

The treatment of scapular dyskinesia should begin with optimizing anatomical alignment, followed by restoring dynamic scapular stability through the strengthening of scapular stabilizers using kinetic chain-based rehabilitation protocols. The kinetic chain, as defined by Steindler, is "a combination of successive joints containing complex motor units." It describes the interconnected movement of joints, where adjacent segments interact to form a continuous chain of motion. This biomechanical model emphasizes that dysfunction in any part of the chain can impact movement quality in both upper and lower segments. The scapula is a foundational component within this system, with surrounding muscles playing a crucial role in stabilizing it.

Postural disorders such as kyphosis can lead to scapular deformities, negatively affecting scapular stability. Rehabilitation professionals and researchers increasingly use the Scapular Muscular Endurance Test (SMET) to assess scapular stability. Given that adolescents are at a heightened risk for musculoskeletal injuries, upper extremity assessments like the SKET may contribute significantly to evaluating this population. However, the validity and reliability of the SMET in adolescents have yet to be established.

This study aims to determine the validity and reliability of the SKET in adolescents.


Eligibility Criteria:
Inclusion Criteria:

* Being between 10-19 years old
* Being willing to participate in the study

Exclusion Criteria:

* Those who have had major surgery or trauma related to the musculoskeletal system, especially the upper extremity and scapular region
* Those with neurological diseases
* Those with rheumatic diseases in the active phase
* Those with systemic diseases (Diabetes, hypothyroidism, infection, malignancy...)
A Study of LY3200327 in Healthy Participants

The purpose of this study is to look at the safety and tolerability of single doses of LY3200327 when given to healthy male and female participants either by injection under the skin or by drip into a vein. The study will help determine how the drug behaves inside the body and how long it takes to disappear from the body. The study will also look for anti-drug antibodies and how these may affect how LY3200327 acts in your body.

The study is expected to last approximately 12 weeks (with screening evaluations up to 4 weeks prior).


Eligibility Criteria:
Inclusion Criteria:

* At the time of initial screening, in general good health
* First-generation healthy Japanese (age 20 to 65 years) will be included

Exclusion Criteria:

* Pregnancy or breastfeeding during the study
* Chronic infection
* Treatment with prohibited medications