cyrilzakka/clinical-trials huggingface dataset:
Music Listening as a Postanesthesia Care Unit (PACU) Nursing Intervention

A randomized comparison clinical trial will be conducted in laparoscopic radical prostatectomy patients in the Weinberg PACU at the Johns Hopkins Hospital. 50 patients will be recruited and randomly assigned by a table of random numbers to either the music listening group (n=35) or the relaxation breathing group (n=35).

Hypothesis:

Laparoscopic radical prostatectomy patients who experience music listening will report decreased anxiety scores and improved pain control scores compared with patients listening to relaxation and breathing.

Null Hypothesis:

There will be no difference in reported anxiety scores and pain control scores between laparoscopic radical prostatectomy patients listening to music versus listening to relaxation and breathing instructions.

Music listening participants who meet inclusion criteria will be consented in the PreOp Unit and asked to complete the Spielberg State Trait Anxiety Inventory (STAI) questionnaire. Patient vital signs will be taken and patient will be invited to listen to music study iPod for 15 minutes prior to changing into a hospital gown.

Intervention:

The music listening group will receive the standard care and a 15 minute patient-preferred music listening selection intervention in the Prep Room and unlimited music listening selection intervention in the PACU once cognitively ready until discharge criteria met. The relaxation breathing group will receive the relaxation and breathing instructions over soft monotone music in the PACU once cognitively ready until discharge criteria met.

Results:

The experimental music listening group will reveal statistically significant decrease postanesthesia anxiety and pain, while lowering the blood pressure, heart rate and amount of opioids after laparoscopic radical prostatectomy surgery compared to the control group.

Conclusion:

The findings of the music listening intervention will provide further evidence to support the practice of music listening to decrease postanesthesia anxiety and pain, while lowering the blood pressure, heart rate and amount of opioids after laparoscopic radical prostatectomy surgery.

Eligibility Criteria:
Inclusion Criteria

* All adult male patients schedule to have a laparoscopic radical prostatectomy surgery who are ages 45 to 80 years of age
* All ethnic backgrounds
* All religions

Exclusion Criteria:

* All patients who do not speak or understand the English language to the extent that it precludes their ability to provide informed consent for the study
Assessing Shoulder Pathways Involving the Cuff

New recommendations regarding care pathways for the management of shoulder pain syndromes have recently been published. We aim to analyze and compare the existing care pathways and identify the most appropriate approaches for different patient profiles.

Our primary objective is to compare pain levels and shoulder function one year after your initial consultation with your general practitioner for this episode. We also seek to assess which healthcare professionals you consult for your shoulder management, the treatments you receive (e.g., analgesics), and any imaging studies you undergo (if prescribed).

We will send you notifications to remind you of the survey completion schedule and provide the link to access the questionnaire.

Participation in this study requires your commitment and adherence to the timeline, as missing data may compromise the analysis of results.

Non-participation in the study will not affect your current medical care.


Eligibility Criteria:
Inclusion Criteria:

* Rotator cuff related shoulder pain
* Consultation with a general practitionner for this disorder in the 6 weeks prior to the inclusion

Exclusion Criteria:

* History of upper limb trauma associated with the current episode of shoulder pain
* Neurologic or rheumatismal shoulder disorder
* Frozen shoulder (current or past)
* History of advanced glenohumeral athritis
* History of shoulder surgery (on the affected side)
Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy

This study is to compare the effects of Betaserc 24mg and placebo on compensation of postural and locomotor deficits (static and dynamic posturography) after vestibular neurotomy in patients suffering from disabling Menière's disease.


Eligibility Criteria:
Inclusion Criteria:

* Patients who have undergone vestibular neurotomy for the treatment of disabling Menière's disease and who have confirmed vestibular areflexia

Exclusion Criteria:

* Other peripheral vestibular disease than Menière's disease
* Central vestibular disease
* Neurological disease
* Contraindication to betahistine
* Pregnant or lactating women
Study of Arm and Putter Movement in Golfers With Golfer's Cramp

The investigators will investigate golfers with visual evidence of an involuntary movement while putting before and after treatment with a low dose of propranolol.

Dystonia affecting athletes has received little research attention and there has been a lack of awareness or interest among both physicians and athletes. Task-specific dystonias or occupational cramps affect people while writing, typing, and or playing a musical instrument. Our group has previously shown that a subset of golfers who complain of the yips appear to have a task-specific dystonia or golfer's cramp. The yips are characterized by an inability to appropriately complete a golf stroke, most often putting and chipping strokes. Most individuals with the yips describe a jerking or shaking movement that interrupts their swing. In many cases the yips are disabling and the golfer, including professional tour players, give up golfing.

Golfers who have evidence of golfer's cramp will putt a series of putts during which they will be monitored for arm movements and putter movements. They will then be treated with a low dose of propranolol to see if there is a change in these parameters.

Eligibility Criteria:
Inclusion criteria:

* Age 18-75
* Complaint of golfer's cramp/yips
* Visual evidence of a movement disorder during putting
* Able to complete 80 putts during the session

Exclusion criteria:

* Contraindication to treatment with propranolol
* Movement disorder not when putting
A Randomized Double-blind, Placebo-controlled Japanese Phase III Trial of ARQ 197 in Hepatocellular Carcinoma (HCC)

The present clinical trial is aiming to evaluate efficacy of ARQ 197 in patients with hepatocellular carcinoma (HCC), who were resistant or intolerable to one systemic chemotherapy regimen including sorafenib.


Eligibility Criteria:
Inclusion Criteria:

* Informed consent form
* ≥20 years old
* Inoperable HCC which is not eligible for locoregional therapy
* Diagnosed as c-Met high in tumor sample
* Radiographic progression is confirmed during or after systemic chemotherapy including sorafenib, or those who are intolerance to the chemotherapy.
* Eastern Cooperative Oncology Group Performance Status (ECOG PS) is 0 or 1
* Child-Pugh Class A
* Having measurable target lesions which are defined by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1,
* Negative pregnancy test results
* Adequate organ function
* Life expectancy of at least 12 weeks

Exclusion Criteria:

* More than 2 prior systemic chemotherapy.
* Prior therapy of c-Met inhibitor (including antibody)
* Any systemic therapy within ≤2 weeks prior to the randomization
* Locoregional therapy within ≤4 weeks prior to randomization.
* Major surgery within ≤4 weeks prior to the randomization
* Concurrent cancer within ≤5 years prior to the randomization
* History of cardiac diseases
* Active clinically serious infections defined as ≥ Grade 3 according to Common Toxicity Criteria for Adverse Effects (CTCAE) 4.0
* Any psychological disorder affecting Informed Consent
* Diagnosis positive for anti-HIV antibody and/or anti-HTLV-1 antibody
* Blood or albumin transfusion within ≤14 days prior to the screening test
* Concurrent interferon therapy against Hepatitis B Virus (HBV)/ Hepatitis C Virus (HCV)
* Symptomatic brain metastases
* History of liver transplantation
* Inability to swallow oral medications
* Confirmed interstitial lung disease
* Pleural effusion and/or clinically significant ascites
* Pregnancy or breast-feeding
* Without consent to effective single or combined contraceptive methods
Ostomy Telehealth For Cancer Survivors

The purpose of this study is to test the benefits of an educational program, the Ostomy Self-Management Training (OSMT) program, for improving patient activation (preparedness to do self-care), self-efficacy (patients' ability to do self-care), knowledge of ostomy/urostomy self-care, quality of life, mood, use of medical services, and financial burden in patients with ostomies. The study will compare patients in the intervention (training) group and patients in the usual care group.

Subjects' participation in this study is expected to last about 7 months. The PI plans to enroll up to 176 subjects at 3 hospitals (University of Pennsylvania, Yale University School of Nursing, and City of Hope in Los Angeles). All patient telehealth education will be coordinated by the University of Arizona in Tucson, Arizona.

Over one million individuals in the U.S. have ostomies. The American Cancer Society estimates 39,610 rectal cancer cases and 74,000 bladder cancer cases will be diagnosed in 2015. Of these, at least 30,000 will receive ostomies, and an additional unknown number due to gynecologic, other gastrointestinal tumors. The HRQOL impact is tremendous and greater than with many other cancer treatments. An ostomy is often a prolonged or lifelong disabling problem for cancer survivors. The adaptation period is quite variable. 18% of participants took at least one year, or never felt comfortable, in their ostomy care. Importantly, many patients cannot attend selfmanagement programs or patient groups for a myriad of reasons, including distance to travel, monetary outlays, comorbidities making travel difficult, or lack of access to transportation. In addition, a national shortage of OCNs means patients with an ostomy, whether newly placed or a long-term issue, receive little help.

It is imperative to study interventions for these cancer survivors aimed to limit family financial burdens, decrease medical care use, and improve well-being. This study has the potential to improve health care outcomes for cancer survivors with ostomies by enhancing their knowledge of and self-efficacy with ostomy care. This will be accomplished by improving the ability to communicate an established educational curriculum developed based on patient needs and desires and refined via a pilot study.

Eligibility Criteria:
Inclusion Criteria:

* All cancer survivors over 21 years of age having undergone a procedure that needed an intestinal stoma (fecal or urinary).

Exclusion Criteria:

* None
Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric ARDS

The aim of this work is to compare continuous infusion vs on need intermittent boluses of Cisatracurium in the early management of pediatric acute respiratory distress syndrome

In the pediatric population, Acute respiratory distress syndrome (ARDS) has a high mortality rate of approximately 24%. In addition, there is a lack of high-quality data to guide the use of non-depolarizing neuromuscular blocking agents (NMBAs) in mechanically ventilated children. Hence, there is a need to evaluate its use in pediatrics.

Eligibility Criteria:
Inclusion Criteria:

1. Children with mild, moderate, and severe ARDS diagnosed according to criteria of Pediatric Acute Lung Injury Consensus Conference (PALICC) in 2015.
2. Children of both sexes aged from one month to 18 years.
3. Children diagnosed with ARDS \<48 hours before enrollment

Exclusion Criteria:

1. Continuous neuromuscular blockade at enrollment
2. Children on phenytoin and carbamazepine
3. Severe liver cirrhosis
4. High-risk medical illness (Bone marrow transplantation within the last one-year, Diffuse alveolar hemorrhage from vasculitis, Chronic respiratory failure, Burns \> 70% total body surface)
5. Previous hypersensitivity or anaphylactic reaction to Cisatracurium
6. Neuromuscular conditions that may potentiate neuromuscular blockade and/or impair effective spontaneous ventilation
Comparing the Efficacy of Reverse Hybrid Therapy and Bismuth Quadruple Therapy

Reverse hybrid therapy achieves a higher eradication rate than bismuth quadruple therapy remained unanswered.

A 14-day hybrid therapy invented by our study group appears very promising in H. pylori eradication, achieving excellent eradication rates of 99% and 97% according to per-protocol and intention-to-treat analyses, respectively. Recently, the investigators demonstrated that the eradication rate of reverse hybrid therapy was higher than that of standard triple therapy. However, whether reverse hybrid therapy achieves a higher eradication rate than bismuth quadruple therapy remained unanswered.

Eligibility Criteria:
Inclusion Criteria:

* Consecutive H pylori-infected outpatients, at least 20 years of age, with endoscopically proven peptic ulcer diseases or gastritis

Exclusion Criteria:

* previous H pylori-eradication therapy
* ingestion of antibiotics or bismuth within the prior 4 weeks
* patients with allergic history to the medications used
* patients with previous gastric surgery
* the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia)
* pregnant women
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults

Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.

Despite the strong results of motor studies, the affects of AIH on sensory function has not been established. We will use a commercially-available hypoxicator that can be programmed to achieve a targeted level of arterial oxygen saturation. We plan to compare 3 previously published protocols that have generated motor facilitation (and a sham condition) to characterize and effects on sensory function in healthy adults.

Eligibility Criteria:
Inclusion Criteria:

* 18 to 40 years of age

Exclusion Criteria:

* Diagnosis of cardiovascular disease (Hypertension, arrhythmias, coronary artery disease, congenital and valvar heart diseases)
* Diagnosis of neuromuscular disease
* Diagnosis of any neurological disease
* Presence of concurrent medical illness including infection, fractures
* Diagnosis of obstructive sleep apnea
* Diagnosis of obstructive/restrictive lung disease
* Diagnosis of exercise induced asthma
* FEV1/FVC\<80% and/or FVC\<80% of predicted value indicating airway obstruction
* Subjects on prednisolone therapy or selective serotonin reuptake inhibitor (SSRI) therapy will be excluded from the study as these pharmacological agents are known to amplify the effects of IH\[22, 23\]
* Diagnosis of epilepsy or history of seizures and attention deficit disorders
* Pregnancy
* Diabetes
* History of coagulation disorders
* History of chronic pain
* Body mass index(BMI)\> 35kg/m2
* Subjects on prescription medicines such as beta blockers and other drugs that are prescribed in any of the exclusionary disorders listed above.
A Retrospective Study to Evaluate the Effectiveness of the Ulthera System

Up to 120 subjects within the study site's practice who have already had an Ultherapy™ treatment to the face and neck will be enrolled to monitor treatment effectiveness. Follow-up visits will occur at 90 and 180 days post-treatment. Study images will be obtained at each follow-up visit.

This is a retrospective, single-center clinical trial to evaluate the efficacy of the Ulthera System for non-invasive treatment of skin texture and laxity six months after treatment. Global Aesthetic Improvement Scale scores, patient satisfaction questionnaires, and quality of life questionnaires will be obtained.

Eligibility Criteria:
Inclusion Criteria:

* Male or female, age 25-85 years.
* Subject in good health.
* Received Ultherapy™ treatment prior to or on October 1, 2011, and must have had pre-treatment baseline photographs taken.
* Willingness and ability to comply with protocol requirements, including returning for follow-up visits.
* Absence of physical or psychological conditions unacceptable to the investigator.

Exclusion Criteria:

* Presence of an active systemic or local skin disease that may affect wound healing.
* Significant scarring in areas treated.
* Open wounds or lesions in the areas treated.
* Severe or cystic acne on the areas treated.
* Inability to understand the protocol or to give informed consent.
A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures

The purpose of this study is to evaluate the efficacy and safety of zonisamide for anti-epilepsy drugs (AEDs) treated subjects with refractory simple partial, complex partial or partial with secondary generalized seizures.


Eligibility Criteria:
Inclusion criteria:

* Subjects must sign and date the informed consent form
* Clinical diagnosis as refractory epilepsy

Exclusion criteria:

* Progressive neurologic disease
* Serious psychiatric disease
* Hemolytic anemia
* G6PD (glucose-6-phosphate dehydrogenase) deficiency
* Acute intermittent porphyrias
* Subjects who have received study drugs (Zonisamide, Lamotrigine) in the past
* Drug or alcohol addiction
* Renal impairment (serum creatinine ≧ 1.5 mg/dl), or hepatic abnormality (ALT or AST \> 2x ULN)
* Stevens-Johnson syndrome
* Progressive exfoliative dermatitis
* Pregnant, lactating or of childbearing potential female
* Regularly taking oral contraceptives
* Hypersensitivity to study drugs
* Severe cardiac disease (New York Heart Association Functional Class III and IV)
* History of malignancy within 5 years

  * Taking valproic acid within 7 days prior to screening
  * Subjects with simple partial seizures without motor component
Evaluation of Hearing Aid Benefit

The present study will investigate the benefit of hearing aids for speech intelligibility (in both quiet and noisy environments) compared to the unaided condition. Participants will include adults with moderate to moderately severe hearing impairment. The participants will complete laboratory-based speech intelligibility assessments with binaural hearing aids and without hearing aids.


Eligibility Criteria:
Inclusion Criteria:

* Moderate to moderately severe sensorineural hearing loss
* Willingness to wear custom hearing instruments during the study.
* Age-normal cognition
* Ability to attend on-site study visits.
Different Treatment Options for Tubal Ectopic Pregnancy:- A Systmatic Review

Ectopic pregnancy is an early pregnancy complication in which a fertilized ovum implant outside the uterine cavity. Implantation may occur anywhere along the reproductive tract with the most common implantation site being the fallopian tube. The incidence of ectopic pregnancy is 1% of pregnant women, and may seriously compromise women's health and future fertility.

Currently, ectopic pregnancy can be often diagnosed before the woman's condition has deteriorated, which has altered the former clinical picture of a lifethreatening disease into a more benign condition in frequently asymptomatic women.


Eligibility Criteria:
Inclusion criteria:

* RCTs and observational studies
* All types of ectopic pregnancies.
* All types of treatments and medications for ectopic pregnancies.
* The long-term survival of patients with or without complications.
* Successful pregnancy and birth.

Exclusion criteria:

* Articles of failed treatments of ectopic pregnancies.
* Articles with over all P value \> 0.05.
* Articles for which the full text is not available in English.
Authentic Connections for Nurse Leaders

The purpose of this pilot study is to test the feasibility and outcomes of a supportive group-based intervention, Authentic Connections, to be used for nurse leaders at Mayo Clinic, Rochester, in a collaboration involving faculty at Arizona State University (ASU) Department of Psychology, Dr. Sunyia Luthar.


Eligibility Criteria:
* In an Nursing Education Specialist (NES) or Clinical Nurse Specialist (CNS) nurse leader role at Mayo Clinic Rochester
* Female gender
* A mother to at least one child or adult child
Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age

The aim of the trial is to evaluate whether the use of oral prednisolone directed by point-of-care testing is useful in acute wheezing caused by rhinovirus in children aged 6-24 months.


Eligibility Criteria:
Inclusion Criteria:

* Wheezing bronchitis diagnosed by a physician
* Need for salbutamol treatment at the emergency department
* Positive nasopharyngeal rhinovirus or picornavirus finding in point-of-care testing

Exclusion Criteria:

* Need for immediate resuscitation
* Immediate transfer to ICU
* Suspected pneumonia based on the auscultation finding
* Suspected serious bacterial infection
* Other respiratory virus finding in the absence of rhinovirus or picornavirus
* Positive respiratory syncytial virus finding
* Positive SARS-coronavirus-2 finding
* Positive Mycoplasma pneumoniae finding
* Positive Bordetella pertussis finding
* Contact with a person with chickenpox within 14 days
* Active chickenpox
* Suspected foreign body of the respiratory tract
* Immunosuppressive treatment
* Systemic corticosteroid treatment within 14 days
* Allergy to corticosteroids
Effects of Red Ginseng on Liver Function

Korea Red Ginseng (KRG) has effect on liver function

Korea Red Ginseng (KRG) has been known as a natural product with anti-inflammatory effect in liver disease. Gut microbiota plays an important roles in the pathophysiology of nonalcoholic statohepatitis (NASH). We evaluated the effect of KRG on the pathophysiology of NASH

Eligibility Criteria:
Inclusion Criteria:

* AST or ALT level \> 50 IU/L

Exclusion Criteria:

* Viral hepatitis
* Alcoholic hepatitis
* Autoimmune hepatitis
* Pancreatitis
* Hemochromatosis
* Wilson's disease
* Drug induced liver injury
* Cancer