cyrilzakka/clinical-trials huggingface dataset:
Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias

Inguinal hernia repairs is clean surgical procedures. However infection may be a concern when prosthetic materials are used. This prospective randomized study has been set to observe if antibiotic prohylaxis is of benefit in mesh repair of inguinal hernias.

There are two group in the study. Control group received no antibiotic prohylaxis, whereas a single dose 1 gr. intravenous cefazoline is given to the patient in prophylaxis arm of the study. 30-days surgical site infection rates and 1 year prosthetic intervention late infection rates are observed and recorded. Side effects of antibiotic used are also recorded.

Eligibility Criteria:
Inclusion Criteria: inguinal hernia repair -

Exclusion Criteria: uncontrolled diabetes mellitus,

-
Effect of Tai Chi on Symptoms in Hemodialysis Patients

The goal of this clinical trial is to learn about the effect of Tai Chi on symptoms in hemodialysis patients.The main question\[s\] it aims to answer are: the effect of Tai Chi on symptoms or the quality of life in hemodialysis patients .Participants will be divided into three groups, one group will be asked to do Tai Chi for 30 minutes three times a week, and the other group will be asked to do Tai Chi imagery for 30 minutes three times a week. The comparison group will be given usual care. Researchers will compare the efficacy of symptoms and quality of life in dialysis patients in each group.


Eligibility Criteria:
Inclusion Criteria:

* Age≥ 18;
* Dialysis age≥ 3 months;
* Survival≥ 12 months;
* The patient has the ability to move independently, can learn independently, and has no reading and comprehension disabilities;
* Informed consent

Exclusion Criteria:

* Inability to move autonomously;
* Have a mental disorder;
* Other serious complications occur
Stress Management and Resiliency Training (SMART) for Family Medicine Residents at Eglin AFB

This research seeks to identify if the practice of the SMART program mindfulness decreases stress and increase resilience in family medicine residents.

This research seeks to identify if the practice of the SMART program mindfulness decreases stress and increase resilience in family medicine residents.

Eligibility Criteria:
\*\*Patients must be able to get care at Eglin Air Force Base (a military installation) in order to participate in this study\*\*

Inclusion Criteria:

* Male and female active duty military family medicine residents
* Age 18 or older
* Amenable to participation in training and filling out questionnaires

Exclusion Criteria:

* Unwilling to participate
Epicardial vs. Transvenous ICDs in Children

This observational study included all patients \<18-year-old implanted with an Implantable cardioverter defibrillator (ICD) at Necker Hospital, Paris, France, from January 2003 to January 2021. Outcomes (ICD-related complications and reinterventions) were compared between epicardial and transvenous ICDs using Cox proportional hazard models.


Eligibility Criteria:
Inclusion Criteria:

* ICD implantation
* Age \< 18 years

Exclusion Criteria:

- Absence of patient's consent
The Effect of Repeated Standardized Patient Use on Students' Anxiety and Learning Levels in Teaching Extremity Examination Skills

Aims: This study aimed to examine the effects of peer assessment and repeated standardized patient use on students' self-confidence and anxiety and their psychomotor skill performance in teaching extremity examination skills.

Design: This randomized controlled experimental study was carried out following the CONSORT checklist.

Methods: The study sample consisted of second-grade nursing students enrolled in the " Health Diagnosis" course in the fall semester of the 2023-2024 academic year (n:67). The students in the peer assessment group performed the upper and lower extremity examinations once whereas those in the standardized patient group performed these examinations three times. Research data were analyzed in IBM SPSS 25.0 (Statistical Package for Social Sciences) software. The Shapiro-Wilk test was used to check whether the data were normally distributed. Parametric and nonparametric tests and descriptive statistical methods were used for data analysis. The significance levels were taken as p\<0.001 and p\<0.05. The scales used were analyzed with the Cronbach alpha reliability coefficient; the scenarios and forms created by the researchers were evaluated with the Lawshe Technique.


Eligibility Criteria:
Inclusion Criteria:

* Second-grade nursing students
* Enrolled in the " Health Diagnosis" course at the Faculty of Health Sciences, Department of Nursing of a university in the fall semester of the 2023-2024 academic year

Exclusion Criteria:

- Students who actively continue their nursing profession as well as their education life
Evaluation of The Clinical Acceptance of Soft Contact Lenses for Myopia Control

The main objective of the study was to evaluate the clinical acceptance of soft contact lenses for Myopia control.

Participants were randomized to wear each study contact lenses for 10 days with investigator and participant masking. The participants who are not contact lens wearer at enrollment wore single vision contact lenses for two weeks during the pre-investigation phase to get adapted to contact lens wear.

Eligibility Criteria:
Inclusion Criteria:

* Age 10 to 16 years;
* Spectacle refraction: -0.75 to -6.00D spherical equivalent, maximum anisometropia 1.25D, cylinder up to -1.00DC
* Best corrected visual acuity of at least 20/25 in each eye.
* Parents/guardians and participant have read and understood the Participant Information Sheet;
* Parents/guardians and participant have read, signed and dated the Informed Consent;
* Have normal eyes with the exception of the need for visual correction;
* Be willing and able to adhere to the instructions set in the clinical protocol and maintain the appointment schedule.

Exclusion Criteria:

* Ocular anterior segment infection, inflammation, abnormality, or active disease that would contraindicate contact lens wear;
* Newly prescribed use of some systemic or ocular medications for which contact lens wear could be contraindicated as determined by the investigator;
* Monocular participants (only one eye with functional vision) or participants fit with only one lens;
* Subjects with slit lamp findings greater than grade 1 (e.g. edema, infiltrates, corneal neovascularization, corneal staining, tarsal abnormalities, conjunctival, anterior segment inflammation) as per ISO 11980, any previous history or signs of a contact lens related corneal inflammatory event (past corneal ulcers), or any other ocular abnormality that may contraindicate contact lens wear at the enrolment visit;
* History of herpetic keratitis, ocular surgery or irregular cornea;
* Enrolment of the family members of the investigator, family members of the investigator's staff, or individuals living in the households of these individuals.
MyMenoPlan: Online Resource for Improving Women's Menopause Knowledge and Informed Decision-making

As part of a National Institute on Aging -funded R01, the investigators developed an evidence-based, multi-media digital resource entitled MyMenoPlan to help women learn about the menopause transition, and the symptoms and treatments of perimenopause/menopause. MyMenoPlan is also designed to help women learn about the effectiveness of treatments for a comprehensive list of midlife symptoms and compare treatments that may help with the specific symptoms women are experiencing.

The purpose of this research study is to:

1. Investigate how women randomly assigned to visit MyMenoPlan use the website (time spent on website, treatment and symptom page views, use of interactive tools, and use of the MyMenoPlan tool).
2. Compare the ratings of women randomly assigned to MyMenoPlan to those randomly assigned to other menopause websites for perceived quality of information, readability, self-efficacy, and credibility of these online menopause resources.

Eligibility Criteria:
Inclusion Criteria:

* As stated above

Exclusion Criteria:

* N/A
Migraine and Body Composition

This research is being done to look at the association between migraine and obesity.

Research into the role of inflammatory markers and other obesity related proteins and chemicals may help us understand migraine and lead to new treatment.

Eligibility Criteria:
Inclusion Criteria:

* Premenopausal women (18-55 years)
* Normal weight (BMI = 18.5 - 24.9) or obese (BMI ≥ 30)
* Diagnosis of episodic or chronic migraine or pain free control

Exclusion Criteria:

* Evidence of pain disorder other than migraine (e.g. irritable bowel syndrome)
* Chronic conditions known to alter risk or pattern of migraine (e.g. hypothyroidism)
* Illnesses that may affect adipokine levels (e.g. diabetes)
* Clinically relevant abnormal glucose/cholesterol levels
* Pregnant women
* Potential participants who are unable to undergo MRI based on standard screening questionnaire (those with brain aneurysm or surgical clips, certain types of artificial heart valves, heart defibrillator or pacemaker, cochlear implants, eye implants, blood vessel coil, recently placed artificial joints, certain types of vascular stents, history of bullets, pellets, BBs, history of any implanted metal or device or who have worked with sheet metal in the past)
Electronic Cigarettes and Nicotine Pouches for Smoking Cessation

Pakistan is one of the most vulnerable low- and middle-income countries with 29 million adult active tobacco users. Smoking cessation services are lacking as the tobacco control initiatives have largely failed to address the smoking endemic. Over the last five years, Pakistan has witnessed the use of innovative tobacco harm reduction such as e-cigarettes, nicotine pouches, and non-nicotine replacement therapies (non-NRTs). However, their use remains limited.

THR products are imported legally as consumer goods and are taxable. The lack of sufficient data for THR and its application is a challenge in gauging their effectiveness in assisting smokers to quit combustible smoking. Evidence-based studies on e-cigarettes and other nicotine products are required to gauge the effectiveness of e-cigarettes and nicotine pouches as smoking cessation aids.

Keeping in view the study objectives, a sample size of 600 participants will be sufficient to assess the effectiveness of e-cigarettes and nicotine pouches for smoking cessation in Pakistan. Of these, 200 participants each will receive e-cigarettes and nicotine pouches along with basic care counseling, while the remaining 200 participants will only receive basic care counseling for 48 weeks. The association of participants' characteristics with smoking and health status will be based on bivariate and multivariate analysis. The simple t-test and variance analysis will assess the differences in intervention indicators between the control and treatment groups. For the inferential analysis, the average treatment impact of the treatments will find using quasi-experimental techniques such as difference in difference (DID) or Propensity Score Matching (PMS).

This study will be evaluated participants at baseline, after their self-decided "quit date,". The follow-up will be a survey every 12 weeks. Results may inform the public, decision-makers, and researchers about the use of e-cigarettes and nicotine pouches helping smokers to quit smoking or switch to less harmful alternatives in the short- and medium-term periods.


Eligibility Criteria:
Inclusion Criteria:

* Participants who are at least eighteen years old.
* More than 10 combustible cigarettes smoke a day at the time of study enrollment.
* Smoked cigarettes for at least a year.
* Participants are willing to stop combustible smoking.
* Participants who can sign a written consent form.
* There can only be one applicant per household.
* Own a phone that supports text massaging.

Exclusion Criteria:

* Women who are pregnant.
* Childbearing mothers.
* Currently using other nicotine- and non-nicotine-based cessation therapies.
* Expectant ladies who intend to become pregnant during the trial's participation term.
* Experienced chest pain, or another cardiovascular event or procedure (e.g., heart attack, stroke, insertion of stent, bypass surgery).
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases

This study aims to explore the safety and efficacy of eliminating the PTV (planning target volume) margins based on online adaptive stereotactic radiotherapy for patients with early-stage non-small cell lung cancer (NSCLC) or pulmonary oligometastases.

This study aims to explore the safety and efficacy of eliminating the PTV expansion margin based on online adaptive stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) or pulmonary oligometastases. In this study, patients will be stratified according to whether they have primary early-stage NSCLC, then randomly assigned in a 1:1 ratio to the study group or the control group. Patients in the study group will receive online adaptive SBRT (without PTV expansion margin), while patients in the control group will receive conventional standard SBRT. After the completion of treatment, patients will be followed up regularly to assess safety and efficacy.

Eligibility Criteria:
Inclusion Criteria:

* Histologically or PET-CT confirmed untreated early-stage non-small cell lung cancer (T1-2N0M0) that is inoperable or where the patient is unwilling to undergo surgery, or PET-CT/chest CT confirmed lung oligometastases (number of metastases ≤3, single lesion diameter ≤5cm).
* Age 18 years or older, regardless of gender.
* ECOG performance status score of 0-2.
* Serum hemoglobin ≥ 80 g/L, platelets ≥ 100,000/μL, absolute neutrophil count ≥ 1,500/μL.
* Serum creatinine ≤ 1.25 times the upper normal limit (UNL) or creatinine clearance ≥ 60 ml/min.
* Serum bilirubin ≤ 1.5 times UNL, AST (SGOT) and ALT (SGPT) ≤ 2.5 times UNL, alkaline phosphatase ≤ 5 times UNL.
* FEV1 ≥ 0.5 L.
* Normal CB6 range.
* The patient and their family agree and sign the informed consent form.

Exclusion Criteria:

* Tumors with bronchial invasion are excluded.
* Any other disease or condition that contraindicates radiotherapy (e.g., active infections, within 6 months post-myocardial infarction, symptomatic heart disease including unstable angina, congestive heart failure, or uncontrolled arrhythmias).
* Pregnant or breastfeeding women, women who have not undergone pregnancy testing, and pregnant individuals.
* Individuals with substance abuse issues, chronic alcoholism, or AIDS.
* Individuals with uncontrollable seizures or loss of self-control due to psychiatric disorders.
* Individuals with a history of severe allergies or specific sensitivities.
Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal Cancer and Their Family Caregivers

This pilot clinical trial studies how well Walking for Recovery from Surgery works in improving quality of life in older adults with lung or gastrointestinal cancer and their family caregivers. A walking program, such as Walking for Recovery from Surgery may help support overall well-being as a caregiver, and may help improve family member or friend's recovery from surgery.

PRIMARY OBJECTIVES:

I. To examine whether the intervention and telehealth approach would be feasible and acceptable.

SECONDARY OBJECTIVES:

I. To examine patient outcome patterns suggesting the potential efficacy of the intervention on self-efficacy, functional status (daily steps, 6-minute walk time, timed up and go), psychological distress, symptoms, and global health status.

OUTLINE:

Patients and caregivers receive Walking for Recovery from Surgery prehabilitation intervention in 4 sessions 3-7 days before surgery, before discharge, and at 2 and 7 days post-discharge.

After completion of study, patients and caregivers are followed up for 2 months.

Eligibility Criteria:
-Inclusion:

* PATIENT: Diagnosis of lung or GI (colorectal, pancreas, liver) cancers
* PATIENT: Scheduled to undergo surgery
* PATIENT: \>= 65 years
* PATIENT: Able to read and understand English
* CAREGIVER: Family member/friend identified by the patient as the primary caregiver before and after surgery
* CAREGIVER: \>= 21 years
* CAREGIVER: Able to read and understand English
* This study will be conducted in patients and family caregivers who are scheduled to undergo lung or GI cancer surgery treatment
* There are no restrictions related to performance status or life expectancy
* All subjects must have the ability to understand and the willingness to sign a written informed consent

Exclusion

• Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study
Investigating the Optimal Remifentanil and Dexmedetomidine Concentration for Uterine Fibroid Ablation

This clinical trial aims to find a better drug concentration of Remifentanil in Uterine Fibroid Ablation. The main question it seeks to answer is:

\[primary hypothesis 1\] Remifentanil concentration of 2.0 ng/mL provides better pain control in Uterine Fibroid Ablation.

There is a comparison group in this study: Researchers will compare Remifentanil concentration of 1.0 ng/mL to see if provides similar pain control with fewer side effects.

Participants will be separated into two groups, one group with a Remifentanil concentration of 2.0 ng/mL and the other 1.0 ng/mL. During uterine fibroid ablation, the patient\&#39;s pain index will be recorded (using a Visual Analogue Scale (VAS) of 0\~10 points). We will also record vital signs during the procedure.


Eligibility Criteria:
Inclusion Criteria:

* Aged between 20 and 65 years old
* American Society of Anesthesiology classification I\~III
* Female patients diagnosed with uterine fibroids by obstetricians and gynecologists

Exclusion Criteria:

1. Patients with heart disease (such as arrhythmia or severe ventricular dysfunction)
2. Patients with chronic kidney disease in stage III or above or dialysis patients
3. Long-term alcohol addiction or drug abuse
4. Patients with abnormal liver index or chronic hepatitis
5. Those who are allergic Remifentanil
6. Those who refuse to participate in the experiment
Effects of Silver Spike Point Therapy on Pelvic Girdle Pain PAIN

The aim of this study is to determine the effects of Silver Spike Point Therapy (SSPT) therapy on pelvic girdle pain and functional activities in pregnancy.The finding of this study will help to establish the role of SSPT therapy to relieve pelvic girdle pain in pregnant females along with exercises. SSP for pelvic girdle pain management can prove to be a useful method. The findings of this study can play a role to establish more rigorous treatment plans for pelvic girdle pain in the pregnant population in the future.

This study will be a randomized clinical trial that will investigate the effectiveness of silver spike point therapy and manual therapy in subjects with pregnancy-related pelvic girdle pain. Subjects with pregnancy-related pelvic girdle pain meeting the predetermined inclusion \& exclusion criteria will be divided into two groups using the lottery method. Pre-assessment will be done using NPRS and PGPQ as subjective measurements and PSFS as objective measurements. Subjects in one group will be treated with silver spike point therapy and manual therapy, the other will be treated with manual therapy only. Each subject will receive 10 treatment sessions, with 05 treatment sessions per week. Post-treatment reading for NPRS, PGPQ, and PSFS will be recorded after the end of the 10th treatment session. Recorded values will be analyzed for any significant difference between pre and post-treatment values SPSS 21.

Eligibility Criteria:
Inclusion Criteria:

* Female aged between 20 to 40 years of age
* Healthy pregnancy
* 14 to 38 weeks gestation
* Expecting a singleton fetus
* 2 out of 3 tests positive for PGP according to European guidelines for
* pelvic girdle pain"(Posterior pelvic pain provocation (P4), Patrick's Faber, Modified Trendelenburg's test)

Exclusion Criteria:

* High-risk pregnancy, Caudaequina Syndrome, Trauma, or spinal surgical history.
* Inflammatory, infective, metabolic, neoplastic, or degenerative conditions.
* Sensory symptoms associated with disc herniation or compressive spinal lesion.
* Any contraindication to exercise.
Educational Intervention for the Promotion of Knowledge and Preventive Health Behaviors Related to Personal Air Pollution Exposure, The Air Study

This clinical trial will conduct an educational intervention to promote knowledge of and preventive health behaviors related to personal air pollution exposure. Air pollution is n ubiquitous environmental exposure that is associated with harmful health effects including lung cancer. The educational intervention is comprised of 2 educational videos that include information regarding air pollution, health effects, and personal preventive health behaviors to reduce air pollution exposure and the use of a wearable air pollution sensor. The knowledge gained from this study may inform future research that will be designed to promote awareness of air pollution and its health effects.

OUTLINE:

Participants watch 2 educational videos during week 3 regarding air pollution, health effects, and personal preventive health behaviors to reduce air pollution exposure. Participants complete questionnaires at weeks 1 and 5.

Eligibility Criteria:
Inclusion Criteria:

* Adults 18 years or older: The evidence for personal strategies to reduce air pollution exposure has been focused on adults
* Live in Seattle, WA: The study is designed to focus on Seattle, WA such as using EnviroFlash alerts
* Own a smartphone: The participant requires a smartphone to setup the Flow app for the air pollution sensor
* Not traveling in the near-term: The study is designed to assess air pollution patterns in the local Seattle area
* Leave your home for at least 7 hours per week: Participants will use a wearable air pollution sensor to measure air pollutant levels from indoor and outdoor sources
Repeat Insult Patch Test for Daily Advance Cetaphil Moisturizing Lotion

Human repeat insult patch test to assess the potential for Cetaphil Moisturizing Lotion Daily Advance to induce sensitization to the skin


Eligibility Criteria:
Inclusion Criteria:

* Age 18-65 years
* Good health
* willingness to cooperate and participate
* willingness to avoid topical products at test sites
* willingness to avoid direct sun exposure to test sites

Exclusion Criteria:

* Individuals with active psoriasis or eczema
* individuals with sunburn, acne, abrasions, scar tissue, or tattoos on test sites, or disease of skin that might interfere
* individuals who have had a mastectomy with axillary nodes were removed
* individuals receiving anticancer, immunosuppressive treatments or medications, or radiation
* pregnant, nursing, or planned to become pregnant
* use of topical steroids or drugs at test sites
* active or untreated skin cancer
* active hepatitis
* current routine or frequent use of high doses of anti-inflammatory drugs
* individuals who have had les than two week rest period since completion of previous patch testing on upper back or upper arms
* individuals with uncontrolled metabolic diseases
Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block.

The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block. The aim of this study is to determine whether this a systemic or local effect.


Eligibility Criteria:
Inclusion Criteria:

* Pre-surgical patients for arthroscopic or open shoulder surgery

Exclusion Criteria:

* Skin infection near block site
* Allergy to local anesthetics
* Peripheral neuropathy
* Proven opioid dependency
* Coagulopathy
* Dementia