cyrilzakka/clinical-trials huggingface dataset:
Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery

Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1. If not properly managed, needle phobia can persist, affecting a patient's experience during each visit. This effect may compound and lead to avoidance behaviors that can delay necessary treatments 2. This issue is particularly relevant in a Mohs micrographic surgery (MMS) clinic where each patient experiences several painful needle injections before the day is over.

Ethyl chloride is gaining popularity among dermatologists for its routine use in clinical practice due to its anesthetic and antiseptic properties, especially as a pre-injection agent. Research indicates that cryotherapy or pre-cooling the skin before administering a local anesthetic may offer benefits over topical anesthetics, such as enhanced pain relief, quicker onset, and better patient compliance 3,4. However, to our knowledge, no studies have specifically examined the effectiveness of pre-cooling with ethyl chloride prior to Mohs micrographic surgery. To address this gap, we're conducting a trial aimed at evaluating the impact of pre-cooling with ethyl chloride on pain perception in adult patients undergoing Mohs micrographic surgery with local anesthetic injections.

The trial is a single-center, split-body study. The split-body design will involve dividing the surgical site into two equal halves, with one half (right side relative to patient) designated as the treatment side (receiving ethyl chloride spray prior to lidocaine injection) and the other as the control side (no ethyl chloride spray prior to injection). During the procedure, the participant will be asked to rate the pain associated with the needle injection AND the pain from infiltration of anesthetic from each side of the wound using the visual analog scale (VAS) scoring system (1 = no pain, 10 = most amount of pain possible). The results of the study will help us better understand how to mitigate pain and anxiety for patients requiring MMS.


Eligibility Criteria:
Inclusion Criteria:

* All patients scheduled for MMS with Dr. Daniel Eisen at UC Davis Health Department of Dermatology (3301 C St #1300-1400, Sacramento, CA 95816)
* Pre-op tumor size at least 1.5 cm (measured on day of procedure)

Exclusion Criteria:

* Skin disorders related to cold temperatures (i.e. cryoglobulinemia)
* Anxiolytic medication within past 4 hours
* Treatment sites around the eyes
* Pre-op tumor size smaller than 1.5 cm (measured on day of procedure)
Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.

The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:

1. An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.
2. The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.
3. An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.

Eligibility Criteria:
Inclusion Criteria:

* right handed
* no history of cardiorespiratory disease
* normal or corrected-to-normal vision based on the 20/20 standard
* no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire

Exclusion Criteria:

* the scores of Mini-Mental Status Examination (MMSE) \< 25 and cognitively intact upon study entry
* history of psychiatric or neurological diseases
* color-blindness
Efficacy of the Act of Urination to Relief the Pain During Flexible Cystoscopy Procedure.

This research is about modification during routine cystoscopy (scope in the bladder) procedure \[ experimental research \]. The goal of the study is to evaluate patient experience with cystoscopy by using procedural modification to reduce pain perception. The investigator aim for quality improvement of the current methods of cystoscopy to achieve a better patient experience.

Study Area

-Department of Urology, Hospital Universiti Sains Malaysia.

Study population. -Patient who is required for flexible cystoscopy procedure attending Urology Unit in Hospital USM

Participants

Inclusion Criteria :

• Adult (\>18 years old)

Exclusion criteria:

* Analgesic use within 24hours
* History of stricture ,urinary tract infection, existing urethral pain
* Secondary procedure(example stent, stone removal, fulguration)

Withdrawal Criteria

* Change of mind
* Found to be outside the parameters of inclusion criteria, and inside the parameters of exclusion criteria
* Breach of Protocol

Eligibility Criteria:
Inclusion Criteria:

* age more 18 years old

Exclusion Criteria:

* Analgesic use within 24hours
* History of stricture ,urinary tract infection, existing urethral pain
* Secondary procedure(exp stent, stone removal, fulguration)
Liver Fat Quantification by Magnetic Resonance Imaging (MRI) - Prediction of Postoperative Complications

The purpose of this study is to objectively quantify liver fat content (LFC) by Magnetic Resonant Imaging (MRI) prior to major liver surgery, and to investigate its association with post-operative complications.

Lack of agreement exists among expert pathologists in the standard histological assessment of hepatic steatosis on biopsy. The impact of different grades of steatosis on postoperative complications after major liver resection remains controversial.

Eligibility Criteria:
Inclusion Criteria:

* Major liver resection (\>= 3 resected segments).
* Patients that received a pre-operative Magnetic Resonance Imaging (MRI).
* Patient over 18 years of age

Exclusion Criteria:

* Patients that underwent liver surgery but \< 3 segments were resected (e.g. wedge liver resection).
* Patient that did not receive a pre-operative MRI
* Patient age less than 18 years of age.
Cycling in Parkinson's Disease

The purpose of this study is to assess the effectiveness of a forced exercise aerobic exercise program, utilizing a cycling activity, on specific gait parameters and balance in individuals with Parkinson's Disease (PD). Design: pilot, feasibility, randomized control, evaluator blinded. Subjects: Twenty four patients with idiopathic PD Hoehn and Yahr (H\&Y) stage II or III. Intervention: Participants randomly assigned to one of two exercise groups, forced exercise or self selected exercise, on cycling machine three times a week for 8 weeks. Both groups to exercise at same aerobic intensity level to keep heart rate at 60-80% heart rate max. Outcomes: Gait parameters of step length, width, and variability as measured by the GAITRite; 6 Minute Walk Test; mini-BESTest (balance testing); exercise tolerance via Patient Reported Outcomes Measurement Information System (PROMIS) scale.


Eligibility Criteria:
Inclusion Criteria:

* Idiopathic Parkinson's Disease
* Hoehn and Yahr Stages II - III.
* Ages 30-80 years
* Medical Clearance
* Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

* MOCA: (Montreal Cognition Scale) : rating of less than 24, indicative of cognitive dysfunction
* Changes in Parkinson's medications within the two weeks prior to starting the study
* Anticipated change in Parkinson Disease medications during the course of the study
* Uncontrolled orthostasis
* Symptomatic coronary artery disease
* Fracture of lower limb within 6 months prior to study onset or significant lower limb orthopedic diagnosis that would limit cycling
* Other significant neurologic diagnoses including multiple sclerosis or vestibular disease
* Acute illness
* Physical therapy within the month prior to study entry
* Subjects already participating in a forced exercise or high intensity exercise program
* Any medical condition that the physician investigator determined would compromise safety.
First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings

This is a non-significant risk study utilizing a device cleared for use by the FDA under its 510(k) clearance. Consented patients will complete their usual dialysis treatment under professional care in an ICHD (In-Center Hemodialysis) setting.


Eligibility Criteria:
Inclusion Criteria:

* Have a diagnosis of end stage kidney disease (ESKD) adequately treated by maintenance dialysis (defined as achieving a spKt/V ≥ 1.2 OR stdKt/V ≥ 2.1) and be deemed stable by their treating nephrologist prior to consent.
* Must sign the informed consent and a Health Insurance Portability and Accountability Act of 1996 (HIPAA) compliant authorization statement.
* Understand the nature of the procedures and the requirements of the Study.

Exclusion Criteria:

* Have a significant cognitive impairment that would preclude informed consent or the capacity for completing dialysis as prescribed by their treating nephrologist.
* In the opinion of the treating nephrologist, any other reason in which study participation would result in undue risk, including but not limited to protocol required prescription parameters.
* Are contraindicated for or not indicated to use the Moda-flx Hemodialysis System™ according to the Instructions For Use (IFU).
Backwards Examination of the Right Colon: A Back-to-back Study

The aim of this study is to evaluate the examination of the proximal colon with the retroflexion colonoscopic technique in terms of feasibility and its possible additive contribution in the detection of important lesions, namely polyps and cancers.

The investigators prospectively examined the additional diagnostic yield of right colon examination with colonoscope retroflexion in consecutive, symptomatic and screening - surveillance patients. Right colon was examined in forward-view first and thereafter, retroflexion was performed to re-inspect it.

Eligibility Criteria:
Inclusion Criteria:

* patients undergoing elective colonoscopy in a Attikon University General Hospital.

Exclusion Criteria:

* patients aged \<18 and \>80 years;
* right colectomy;
* recent abdominalsurgery;
* multiple diverticula of the right colon;
* American Society of Anesthesiology (ASA) physical status classification grade IV;
* inflammatory bowel disease and polyposis syndromes.
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of BMS-986278 and the Effects of BMS-986278 on Cardiac Repolarization in Healthy Participants

The purpose of this study is to determine the safety, tolerability, and pharmacokinetics (PK) of high dose of BMS-986278 in healthy participants and to assess the effect of BMS-986278 on the ECG intervals in healthy participants.


Eligibility Criteria:
Inclusion Criteria:

* Female individuals not of childbearing potential (INOCBP) and males.
* Healthy as determined by medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory assessments.
* Body mass index (BMI) 18.0 to 32.0 kg/m2 , inclusive, for Parts A and B.

Exclusion Criteria:

* Any significant acute or chronic medical illness as determined by the investigator.
* History of clinically relevant cardiac disease as determined by the investigator, symptomatic or asymptomatic arrhythmias, presyncope or syncopal episodes, or additional risk factors for ventricular arrhythmias.
* Any significant history of disease of the cardiovascular system that in the opinion of the Investigator makes the participant unsuitable for enrollment into the study.
* Other protocol-defined inclusion/exclusion criteria apply.
Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer

Total mesorectal excision (TME) is a rather new operation technique in the treatment of rectal cancer. It is known to reduce the rate of local recurrences. However, the influence on long-term survival is unclear.

Background

The TME technique for rectal cancer surgery was introduced in our department in summer 1995. TME is known to reduce the rate of local recurrences. However, its influence on long-term survival in unclear.

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Objective

Study the influence of a new operation method (TME) on outcome (local recurrence, survival).

Methods

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Eligibility Criteria:
Inclusion Criteria:

* adenocarcinoma of the rectum
* 16 years and older
CPB for Arthroscopic Hip Surgery

Arthroscopic hip surgery is being increasingly performed to treat both intraarticular and extraarticular hip diseases. Despite the minimally invasive approach, patients undergoing arthroscopic hip surgery still suffer severe pain due to the complex nature of hip innervation. Postoperative pain reduces patient satisfaction and delay patient recovery and discharge. The efficacy of regional anesthesia techniques in postoperative pain management have been proved in various surgeries. However, it remains controversial whether or not peripheral nerve blocks can significantly improve postoperative analgesia after hip arthroscopy.

Several studies have shown that the fascia iliac block cannot improve postoperative analgesia for hip arthroscopy because it blocks only some branches of the lumbar plexus but not the sacral plexus. Circum-Psoas Block (CPB) which has been defined in recent years is able to block the lumbar plexus nerves as well as sacral plexus such as the sciatic, superior gluteal, and inferior gluteal nerves. Therefore, the investigators predict that it can provide effective postoperative analgesia for hip arthroscopy. In this study, the researchers aim to investigate the effectiveness of CPB in hip arthroscopy.


Eligibility Criteria:
Inclusion Criteria:

* Primary unilateral ambulatory hip arthroscopy
* Age 18 to 70 years
* ASA physical status I to III
* Ability to follow the protocol.

Exclusion Criteria:

* Age \<18 or \>70 years of age
* BMI above 40
* Contraindications to peripheral nerve blockade
* Pregnancy
* Chronic pain condition requiring opioid intake at home
* Allergy to opioids or local anesthetics
* Patient refusal
Pilot Study of Metabolic Syndromes and HIV Infections in Indian Tibetans

Kaohsiung Medical University Chung-Ho Memorial Hospital will provide a long-term free medical service in Indian Tibetans since July 2010. The investigators plan to investigate metabolic syndromes and HIV infection in Indian Tibetan community. The investigators will survey the prevalence and risk factors by means of HIV quick test and questionnaires. Since there is lacking of prevalence survey for metabolic syndrome and HIV infection in Tibetan colony of India, the investigiators will carry out this survey under the support and assistance of Department of Health of Central Tibetan Government.


Eligibility Criteria:
Inclusion Criteria:

Tibetan colony of India

Exclusion Criteria:

non-Tibetan colony of India
Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease

A 2 x 2 cross-over dietary intervention trial designed to investigate the effects of low glycemic index (LGI) versus high glycemic index (HGI) diet on hepatic fat accumulation and gut microbiota composition in participants with NAFLD.

Participants will be allocated randomly to a 2-week either high GI (HGI) or low GI (LGI) diet followed by a 4-week wash-out period and then the LGI or HGI diet, opposite to the first 2-weeks (N= 16).


Eligibility Criteria:
Inclusion Criteria:

* • Adult males and females aged from 18 to 65 years (balanced number).

  * Detected NAFLD by CAP-FibroScan™ \>288dB/m or by MRI-PDFF) \> 5% fat of liver weight.
  * Body mass index ≥ 25 kg/m2
  * Have current moderate to high GI diet intake of ≥ 60 (Assessed from a completed 7-day food diary).
  * Abdominal obesity (Waist circumference \> 102 cm for males and \> 88 cm for females)
  * Able to give informed consent.
  * Able to undergo MRI/S and CAP-FibroScan™.

Exclusion Criteria:

* • Current smokers and excessive alcohol drinkers (\> 14 units/week).

  * Perimenopausal (irregular periods) women.
  * Participants with other liver abnormalities.
  * Participants with history of gastrointestinal surgeries, depression, eating disorders or difficulties.
  * Participants using pharmacologic agents for obesity or NAFLD.
  * Participants with type 1 diabetes.
  * Participants with type 2 diabetes on second line medications (eg GLP-1 analogues, sulfonylureas).
  * Participation in any other trial in the last 3 months.
  * Participants on any special diets (e.g. vegetarians).
  * Intolerance to foods included in the diet plan.
Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation

Currently, standard-of-care tractography is based on information obtained from diffusion tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is routinely obtained on neurosurgical patients to assist in pre-operative planning. The primary objective of the proposed study is to determine the ability of msHARDI-based tractography to discern fibers in edematous brain regions.


Eligibility Criteria:
Inclusion Criteria:

* brain lesions, including but not limited to tumors, epileptic foci, and vascular abnormalities, in or around eloquent brain regions (i.e., motor, language);
* clinical need for pre-operative 'advanced imaging' (which includes conventional DTI);
* age between 18-80 years of age;
* male or female gender. Eloquent regions include: Temporal and frontal lobes (speech/language); bilateral occipital lobes (vision); bilateral parietal lobes (sensation); and bilateral motor cortex (movement).

Exclusion Criteria:

* a contraindication for obtaining an MRI scan (e.g. implanted devices, retrained foreign body)
* pregnancy
* absence of the capacity to make medical decisions or provide informed consent.
Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation

There is a need to compare the efficacy of PVI versus PVI plus catheter ablation, which includes ablation of complex fractionated atrial electrograms (CFAE) and linear lesions in the same procedure. If it is found that the PVI alone is as effective as PVI plus catheter ablation of CFAE and linear lesions, it may reduce the need for catheter ablation.


Eligibility Criteria:
Inclusion Criteria:

(Step 1 - Registration)

* The subject is 18 years of age or older
* Left atrium \< 6.0 cm (Trans Thoracic Echo - TTE - parasternal 4 chamber view
* performed within 6 months)
* Documentation of AF that terminates spontaneously or with intervention within 7 days of onset (PAF) Failed or refractory to one AAD (class I and/or III)
* Provided written informed consent
* Be eligible for an AF ablation procedure for Paroxysmal AF

(Step 2 - Randomization)

* Sustained AF following PVI with ability to receive additional linear or focal intracardiac catheter ablation

Exclusion Criteria:

(Step 1 - Registration)

* Pregnant or planning to become pregnant during study
* Co-morbid medical conditions that limit one-year life expectancy
* Previous cardiac surgery
* Patients who have active infection or sepsis
* Patients with esophageal ulcers strictures and varices
* Patients who are contraindicated for anticoagulants such as heparin and warfarin
* Patients who are being treated for ventricular arrhythmias
* Patients who have had a previous left atrial catheter ablation for AF (does not
* include ablation for AFL or other supraventricular arrhythmias)
* Current participation in another clinical investigation of a medical device or a drug, or recent participation in such a study within 30 days prior to study enrollment
* Not competent to legally represent him or herself (e.g., requires a guardian or
* caretaker as a legal representative)

(Step 2 Randomization)

* Not able to receive additional linear or focal intracardiac catheter ablation
Longitudinal Assessment of Pain-Related Patient-Reported Outcomes After Surgery

Little is known about pain-related outcomes experienced by patients in the first few weeks after surgery, once they are discharged from hospital.

This study aims to characterize pain, pain-related interference, and early neuropathic pain in the sub-acute phase after surgery.

A high proportion of patients experience moderate to severe pain after surgery. However, most of the knowledge about this comes from studies where patients are evaluated in the hours and up until the first postoperative day. Alternatively, patients are assessed several months (eg 3 or later) after surgery, to evaluate the development of chronic pain related to surgery (CPSP) and most patients do not develop CPSP.

This study aims to learn how patients recover concerning pain and function once they return home after surgery. How long is it before they can resume their daily activities and to do so in comfort? Do they take treatment for pain? Do they have pain restricted to the surgical incision or it is more widespread? There is little knowledge as to whether there are signs of nerve injury in the days close to surgery. This type of pain might lead to chronic pain in later stages.

Patients will be assessed at three time points: the first day after surgery, the 7th day after surgery, and 1 month.

The information we obtain will offer healthcare providers, from multiple hospitals, information about the care they provide to their patients for pain while patients are still in hospital and insights as to how the care might be improved, once they are discharged.

Eligibility Criteria:
Inclusion Criteria:

1. Adult
2. On the first post-operative day and back on the ward for at least 6 hours
3. Gives consent for assessment at 3-time points

Exclusion Criteria:

1. The patient is unable to communicate
2. The patient is cognitively impaired
3. The patient is asleep
4. The patient is too ill or in too much pain and does not wish to be interviewed
5. The patient does not wish to fill in the outcomes questionnaire