cyrilzakka/clinical-trials huggingface dataset:
Comparison of Image Quality Between "Double Low Dose" Liver CT and Standard Liver CT

In patients with malignancies, contrast-enhanced abdominal CT (hereafter abdominal CT) plays an important role in detecting carcinoma recurrence and assessing treatment response. In this study, we aim to investigate whether such a "double low" dose CT is feasible in patients with liver metastases of colorectal cancer using a vendor-agnostic artificial intelligence-based noise reduction and contrast enhancement software.


Eligibility Criteria:
Inclusion Criteria:

* colorectal cancer (CRC) patients
* on surveillance or monitoring for liver metastasis (of CRC)

Exclusion Criteria:

* any relative or absolute contra-indication of CECT
* diffuse infiltrative type of liver metastasis or on monitoring for too many liver lesions
Evaluation of Anatomical Results and Sexual Functions After Unilateral and Bilateral Laparoscopic Suture Sacro-hysteropexy Operations

The study was planned as prospective and randomized. For the study, patients will be randomized into two groups as unilateral and bilateral suture sacro-hysteropexy operations.

The study was planned as prospective and randomized. For the study, patients will be randomized into two groups as unilateral and bilateral suture sacro-hysteropexy operations.Computerized random number table will be used as randomization method. Patients who agree to participate in the study and fulfill the inclusion criteria will be evaluated on the effects of prolapse on quality of life and sexual function before and after the surgical procedures and their complaints and satisfaction will be questioned. Surgical success and complications will be evaluated. Changes in the level of prolapse will be evaluated.

Eligibility Criteria:
Inclusion Criteria:

1. Patients between the ages of 18-60
2. No previous prolapse surgery
3. Not having a chronic disease
4. Having stage 3-4 prolapse

Exclusion Criteria:

1. Outside the age range of 18-60 years
2. Previous prolapse surgery
3. Having early stage (1-2) prolapse
4. History of chronic disease
Rivet PVS Therapy in Group 2 PH-HFpEF Canada

This clinical investigation is a prospective, multicenter, non-randomized, open-label, Early Feasibility Study to evaluate the safety, performance, and initial clinical efficacy of the Rivet PVS therapy in patients with symptomatic pulmonary hypertension.


Eligibility Criteria:
Select Inclusion Criteria:

* Age ≥ 18 years
* Prior diagnosis of Group 2 PH due to HFpEF, with at least one of the following resting hemodynamic criteria confirmed in the past year by right heart catheterization

  1. mPAP \> 20 mmHg at rest
  2. mPAP/CO slope \> 3 mmHg/L/min with exercise
* Confirmation of the following hemodynamic criteria during supine exercise: PCWP ≥ 25 mmHg, or PCWP/CO slope \> 2 mmHg/L/min
* Chronic symptomatic heart failure documented by the following:

  1. NYHA HF Class II with history \> II, or Class III, or ambulatory Class IV
  2. ≥ 1 HF hospitalization, or healthcare facility with IV diuretics or intensification of oral diuresis for HF within 12 months, or NT-pro BNP value \> 400 pg/mL in normal sinus rhythm or \> 750 pg/mL in atrial fibrillation in past 6 months
* Ongoing stable guideline directed medical therapy (GDMT) for HF and medically optimized per treating cardiologist according to current ACCF/AHA guidelines that is expected to be maintained without change for 1 month (excluding diuretic dosage changes for HF optimization within 30 days of the Index Procedure)
* 6MWD ≥ 100 m

Select Exclusion Criteria:

* Any therapeutic intracardiac intervention within the last 30 days
* PH Group 1, 3, 4 or 5
* Mean RAP \>16 mmHg by RHC at rest on room air
* Right ventricular dysfunction, defined as one or more of the following

  1. Greater than moderate RV dysfunction as assessed by TTE and/or MRI
  2. RV FAC \< 35%
  3. TAPSE \< 14 mm via TTE
  4. RV size severely enlarged compared to LV size as estimated by TTE and/or MRI
* Severe tricuspid valve regurgitation
* Peak systolic pulmonary arterial pressure \> 80 mmHg by RHC at rest while awake
* Mean pulmonary arterial pressure \> 50 mmHg by RHC at rest while awake
* PVR \> 6 Wood units at rest while awake on room air
* Left ventricular ejection fraction \< 50%
* Severe heart failure, defined as one or more of the following:

  1. ACC/AHA/ESC Stage D heart failure, non-ambulatory NYHA Class IV HF
  2. If BMI \< 30, Cardiac Index \< 2.0 L/min/m2
  3. If BMI ≥ 30, Cardiac Index \< 1.8 L/min/m2
  4. Requires continuous intravenous inotropic infusion
  5. Requires mechanical circulatory support
  6. Currently on the cardiac transplant waiting list
* Chronic renal dysfunction defined as: eGFR \< 35 mL/min/1.73 m2 by the CKD-Epi equation
* Chronic pulmonary disease defined as one or more of the following:

  1. Requires continuous home oxygen therapy
  2. Recent hospitalization for exacerbation within 12 months prior to screening
  3. FEV1 \< 50% predicted
Effect of Genicular Nerve Block on Proprioception in Knee Osteoarthritis

The study was conducted to investigate the effect of genicular nerve block on pain, quality of life, and proprioception, which are already diminished due to the impact of osteoarthritis in individuals with knee osteoarthritis.

Does genicular nerve block reduce pain and improve the quality of life in patients with knee osteoarthritis? Does genicular nerve block affect proprioception in patients with knee osteoarthritis?

Osteoarthritis (OA) is described as a degenerative joint disease characterized by cartilage erosion, osteophytes, subchondral sclerosis, and changes in the joint capsule, commonly observed in the elderly. Knee osteoarthritis is identified as the most prevalent form, with an increasing prevalence attributed to aging. It is recognized as a leading cause of disability, resulting in reduced quality of life and increased healthcare costs. Major risk factors include age, genetics, obesity, and muscle weakness. Current treatments focus on symptom management, with options including medication, physical therapy, and surgery.

Genicular nerve block is a minimally invasive procedure used to manage knee osteoarthritis pain by administering local anesthetics and corticosteroids near specific genicular nerves under ultrasound guidance. Temporary pain relief for up to three months has been reported, and the procedure is considered well-tolerated.

Proprioception is defined as the sense of joint and limb position, mediated by receptors located in muscles, tendons, and joints. Assessment can be performed through simple methods, such as evaluating the ability to recognize specific joint angles or positions during passive or active movement. Proprioceptive deficits are frequently observed in osteoarthritis, and a better understanding of these changes is suggested to guide treatment strategies.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of bilateral primary knee osteoarthritis according to ACR (American College of Rheumatology) criteria.
* Age between 55 and 75 years.
* Presence of knee osteoarthritis classified as Grade 2 or Grade 3 according to the Kellgren-Lawrence grading system on radiographs taken within the last year.
* Knee pain lasting longer than 6 months.
* Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, total score 48-96

Exclusion Criteria:

* Severe knee trauma within the last 6 months.
* History of surgical operation on the knee region.
* Intra-articular steroid and/or hyaluronate injection into the knee joint within the last 6 months.
* Physical therapy targeting the knee within the last 6 months.
* Regular use of NSAIDs within the last 6 months.
* Presence of acute synovitis.
* Neurological deficits in the lower extremity.
* Presence of an inflammatory disease.
* Poor general health condition (e.g., heart failure, advanced asthma, history of malignancy).
* Any endocrine disorder that may cause polyneuropathy.
Automated SMS Reminders to Parents on Their Cell Phones Can Significantly Improve the on Time Vaccination Rates Children in Pakistan

The investigators plan to test the effectiveness of reminders to parents/guardians on cell phones through short messaging system (SMS) in improving the on-time routine immunization for children in Pakistan. SMS message as a reminder tool can be very effective in health care settings at public health scale. This study will be conducted in an urban- squatter settlement area, Ibrahim Haidry union council in Karachi. Parents/guardians of children randomized in intervention arm will be sent SMS reminders vaccination visit reminders at 6, 10 and 14 weeks of life.

The immunization coverage in Pakistan is still well below the desired level, leading to continued polio transmission, large measles outbreaks and thousands of deaths from vaccine-preventable illnesses. A major reason for poor childhood vaccine coverage is the lack of awareness among parents regarding the need for immunization in children, and the importance of completing the entire series of vaccines. This result in significant drop-out between vaccines delivered at birth and later in the infancy period. Customized short messaging system (SMS) text can be designed as personally tailored messages to remind and inquire parents regarding vaccination for their children according to the EPI schedule. We plan to test the effectiveness of reminders to parents/guardians on cell phones through short messaging system (SMS) in improving the on-time routine immunization for children in Pakistan. This study will be conducted in an urban- squatter settlement area, Ibrahim Haidry union council in Karachi, Pakistan. Our experimental plan has three components: First, we will conduct baseline survey of parents at our study site to explore their preferences for text for immunization reminders. Simultaneously, we will develop a computerized application for reminders scheduling. This application will contain the phone number, message information, language preferences and date on which the message will be sent. It will be interfaced with the gateway to send the message. Lastly, we will conduct a randomized controlled trial to determine the effectiveness of automated SMS reminders to parents in improving the on-time vaccination rates in children. If the result shows that the vaccines compliance can be increased through the SMS reminders, this program can be incorporated with the existing systems to collect the cell phone numbers of parents at the time of child's first contact with the health system and sending auto generated reminders for vaccine compliance at national level.

Eligibility Criteria:
Inclusion Criteria:

* Child should be less than 14 days of age
* Parent/guardian or at least one person in the household having a valid cell phone connection
* Parent/guardian provides consent

Exclusion Criteria:

* Child more than 14 days of age
* Not a valid cell phone connection in the household
* Parent/guardian not providing consent
Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

We wanted to test the hypothesis that prostaglandin inhibition reduces the down regulation of u-AQP-2 induced by fasting


Eligibility Criteria:
Inclusion Criteria:

* (1) Genders; both mal and female
* (2) Age; 18- 65 years old
* (3) BMI; below 30
* (4) Females had to bee in oral contraceptive treatment

Exclusion Criteria:

* (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs
* (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose)
* (3) Albuminuria or glucosuria
* (4) Cancer
* (5) Arterial hypertension
* (6) Alcohol abuse
* (7) Use of tobacco
* (8) Medical treatment, except oral contraceptives
* (9) Pregnancy or breast feeding
* (10) Medicine abuse
* (11) Donation of blood less than 1 month before the study.
The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

* 20 postmenopausal women unexperience in strength training or resistance training, without musculoskeletal, neurological diseases, and cardiovascular limiting-diseases were recruited.
* Maximum strength of lower limbs during leg-press exercise was measured for future analysis.
* The force-time curves were measured during climbing a step and rising from a chair.
* A fragility phenotype test was applied to the subjects to determine frailty phenotype classification, including; weight loss of greater than 10 lbs in the past 12 months, maximal handgrip strength, time to walk 15-ft at usual pace, self-reported leisure time physical activity, and self-reported exhaustion.
* The anthropometric measurements were performed by dual energy X-ray absorptiometry.

Eligibility Criteria:
Inclusion Criteria:

* Postmenopausal women

Exclusion Criteria:

* Unexperienced in strength training or resistance training.
* Not musculoskeletal diseases.
* Not neurological diseases.
* Not cardiovascular limiting-diseases.
* Not fragility or pre-fragility phenotype.
Cohort Study to Assess the Level of Compliance in Undertaking Breast Self Examination Among Women Attending Preventive Oncology Clinic

Breast cancer is the most common cancer among women residing in majority of the urban areas in India. The deaths due to breast cancer are mainly a result of late presentation of the symptoms due to lack of awareness of the signs and symptoms of the disease and lack of knowledge of performing BSE. The BSE technique can be a good tool for improving the awareness about the symptoms of breast cancer. Hence, we propose a pilot study of short duration (3 months follow-up), to assess the level of compliance to BSE and assess the various reasons for non-compliance. Based on the results of this study a long term cohort study will be planned with similar objectives.

This is an observational cohort study about BSE among women attending the Preventive Oncology (PO) Clinic, TMH. All women attending for screening of common cancers at the Preventive Oncology OPD at TMH are demonstrated the technique of BSE and advised on when, how and why to perform BSE.

Women attending the PO clinic and who have mentioned their residential address as Mumbai and provided contact number will be invited to participate in the study. They will be explained the study protocol and those who are interested in participating will be offered informed consent forms. The women who sign the informed consent form will be enrolled into the trial.

The data regarding the socio-demographic details and level of knowledge, attitude and practice (KAP) about breast cancer and BSE will be collected from the participating women. They will be asked if they have any doubts regarding the technique of BSE and their willingness to perform BSE. Thereafter, a follow-up period of 3 months, the women will be contacted telephonically to collect the data to assess the level of compliance to BSE and the reasons for non-compliance, if any. Also, the compliant women will be asked if they have observed any abnormal changes in their breasts and have they visited the clinician for the same. And subsequently, their health care seeking behaviour will be studied.

The data collected before and after the follow-up will be entered in the SPSS software and analyzed using simple statistical tests like mean, chi-square, t-test and univariate and multivariate analysis.

Eligibility Criteria:
Inclusion Criteria:

* Women attending Preventive Oncology Clinic during the month of November-December 2010.
* Women undertaking BSE training.
* Residential address mentioned as Mumbai.
* Contact number available.

Exclusion Criteria:

* Women residing outside Mumbai, Maharashtra.
No-touch RFA Versus Traditional RFA for Small Hepatocellular Carcinoma

Traditional RFA treatment has been a curable therapy for small hepatocellular carcinoma (diameter≤3cm). This technique ablates the tumor via radio frequency by inserting an electrode needle directly into the tumor. This clearly violates no-touch technique based on the principle of surgical oncology. Thus the 1-year recurrence rate of the cancer is up to 30% after the treatment, and the 3-year tumor-free survival rate is only 20% - 40%. No-touch RFA treatment avoids the direct contact with the tumor that can cause the spread of cancer cells in the liver, or the Antrim spread, Therefore it has been suggested that no-touch RFA treatment reduce the recurrence rate after operation in comparison with the traditional RFA treatment. This research project aims at using the prospective randomized comparative method to compare the short-term and the long-term curative effects between no-touch RFA and traditional RFA treatments for small hepatic carcinoma.


Eligibility Criteria:
Inclusion Criteria:

1. Primary hepatocellular carcinoma, according to the postoperative pathological examination as the standard, or the diagnostic criteria with reference to the 2012 American Association for the Study of Liver Diseases if the pathological evidence is not available;
2. A single tumor with a diameter ≤3cm;
3. The tumor that has not invaded the portal vein, the hepatic vein, or the secondary branch;
4. Liver function classified as Child A or B;
5. Liver reserve function test with ICG-R15 (indocyanine green retention at 15min) ≤30%, and the important organs that can function with the tolerance of RFA or partial hepatectomy;
6. No significant coagulopathy: platelet count \> 50,000,000,000 /L, prolonged prothrombin time \< 5 seconds;
7. Age 18 - 70 years old;
8. No acceptance of other anti-cancer therapy before the treatment.

Exclusion Criteria:

1. Complication of severe portal hypertension: a history of upper gastrointestinal bleeding, a history of severe hypersplenism, or refractory ascites;
2. Patients with extrahepatic metastasis or lymph node metastasis;
3. Patients with multiple liver tumors found from imaging exam or during the treatment;
4. Patients with pathological examinations showing the other tissue type of liver cancer after the treatment;
5. Patients who expect to receive a liver transplant;
6. Patients whose preoperative imaging exam indicates the tumor close to the gallbladder, hilar major blood vessels, bile ducts and surrounding vital organs, with a potential of serious injury by mistake or serious complications during the treatment.
Investigating the Role of Resistance Exercise Frequency in the Regulation of Skeletal Muscle Mass

This study will investigate whether manipulating resistance exercise frequency impacts muscle protein synthesis rates. The investigators will test the hypothesise that a higher resistance exercise frequency will result in greater muscle protein synthesis rates than a lower resistance exercise frequency.

Resistance exercise is currently the most effective means of building or maintaining muscle mass. Resistance exercise guidelines generally suggest that those looking to increase muscle mass should train each muscle group once to twice per week. However, it has been proposed that it may be of greater benefit to train a muscle group with a higher frequency (i.e., four to six times per week) than currently suggested. If true, completing the same total volume of resistance exercise in more frequent, smaller bouts could prove to be a more beneficial strategy to optimally build or maintain muscle mass.

Therefore, this study will investigate whether manipulating resistance exercise frequency impacts cumulative muscle protein synthesis rates in young individuals. Participants will undergo a 7 day period of habitual activity before completing the same total volume of resistance exercise as either; i) one isolated bout (low frequency) or ii) five smaller bouts (high frequency) over a period of 7 days.

Eligibility Criteria:
Inclusion Criteria:

* Body mass index (18.5-29.99 kg/m2)
* Untrained - defined as: Perform activities of daily living and recreation but have completed no regular lower body resistance-type exercise (e.g., weight training) activity in the last year.
* Good general health

Exclusion Criteria:

* Lidocaine allergy
* Hypertension (≥140/90 mmHg)
* Current participation in another clinical study
* Previous participation in this study
* Bleeding disorder/s
* Current or recent smoker
* Vegetarian or vegan
* Past history of substance abuse and/or taking prescription or non-prescription medication (e.g., beta-blockers, insulin or thyroxine) or supplements that may influence normal metabolic responses.
Stress Management Intervention in Inner City Adolescents With Asthma

The study will utilize a stress management program delivered over 10 sessions that is hypothesized to result in decreased stress levels and improved coping strategies in an inner city adolescent asthma population. Participants will include adolescents ages 10-15 years with physician diagnosed asthma. The outcome measures will be obtained via psychosocial questionnaires and spirometry.


Eligibility Criteria:
Inclusion Criteria:

* Ages 8-15 years of age
* Physician diagnosed asthma based on NHBLI guidelines
* English speaking
* Child assent/parental consent

Exclusion Criteria:

* Refusal of child assent/parental consent
* Non-English speaking
* History of psychiatric illness, autoimmune disease, HIV/AIDs, smoking history.
Evaluation of Functional and Social Changes After Bariatric Surgery

After bariatric surgery there are big changes in the daily functions, activities and social participation of the patients.

This is a prospective study that examine daily performance and daily participation by questionnaires, before and after bariatric surgery.


Eligibility Criteria:
Inclusion Criteria:

* Overweight patients who are fit for surgery .

Exclusion Criteria:

* Children, Neurological patients, amputations