cyrilzakka/clinical-trials huggingface dataset:
Multimodal Exercise Training to Reduce Frailty in People with Multiple Sclerosis

Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the first to establish the feasibility of targeting frailty in pwMS and will begin to examine the dynamic nature of frailty in MS. These advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in MS.


Eligibility Criteria:
Inclusion Criteria:

* Subjects must be aged 40-65 years old to be enrolled in this study.
* Subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered.
* Subjects must have a confirmed diagnosis of MS by the treating neurologist
* be free from MS relapses in the last 30 days
* have an Expanded Disability Status Scale (EDSS) score ≤ 6.0
* be fluent in spoken and written English.

Exclusion Criteria:

* unable to walk unassisted for at least ten meters
* are diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.)
* exhibit severe cognitive impairment (as determined by a Mini-Cog score \<3)
* are diagnosed with active psychiatric problems.
* unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis)
* arthritis of the lower limbs
* acute lower back or lower limbs pain
* rheumatic and/or severe orthopedic problems that may interfere with resistance training.
Hydrotherapy CP and Lying Down to Sitting Position

The purpose of this study is to investigate the effect of a very specific hydrotherapy programm on the movement from lying down to sitting position for children with CP

40 children aged 5-11 years with cerebral palsy and difficulty in the transfer activity from lying down to sitting position were randomly divided into 2 groups of 20 children, a land group and a water group. The children of the land attended a neurodevelopmental treatment program and the water group a very specific program in hydrotherapy on combined rotation at all levels. The water program was implemented by specialized physiotherapists in hydrotherapy. The duration of the program for both groups was 3 months. On the first and last day of the intervention, an evaluation of all children was performed using the GMFM and PBS evaluation tests of the evaluation parameters of the transfer from the lying position to the sitting position.

Eligibility Criteria:
Inclusion Criteria:

* Cerebral palsy
* DIfficulties from lying down to sitting posistion

Exclusion Criteria:

* Surgery or injection of botilium toxin in the last year.
* Scheduled surgery or injection of botilium toxin.
* Uncontrolled seizures.
* Do not run elementary commands or play a test representation.
* Autism.
* Syndromes without OP.
* Serious vision problem.
* Absence from the treatment program for more than a week.
Comparison of Focused and Radial Extracorporeal Shock Wave for Carpal Tunnel Syndrome

Extracorporeal shock wave is a novel treatment for peripheral nerve entrapment. This study was designed to compare the efficacy of focused and radial extracorporeal shock wave for carpal tunnel syndrome.

Both focused and radial extracorporeal shock wave had been proved to treat carpal tunnel syndrome by several studies. However, there was no study comparing these two methods. Considering different mechanisms and costs, this randomized comparative trial would be conducted to compare the efficacy of focused and radial extracorporeal shock wave for carpal tunnel syndrome.

Eligibility Criteria:
Inclusion Criteria:

* Clinical and electrophysiological diagnosis of CTS

Exclusion Criteria:

* Cervical radiculopathy
* Polyneuropathy
* Brachial plexopathy
* Thoracic outlet syndrome
* Previous wrist surgery or steroid injection for CTS
Isometric Exercises With and Without Pressure Biofeedback in Computer Users With Cervical Spine Overload

Neck pain is defined as the pain experienced from the base of the skull or occiput to the upper part of the back and extending laterally to the outer and superior bounds of the shoulder blade. Office work is a kind of job that demands sitting for prolonged time requiring the use of computer. These two factors are mainly responsible for overloading of the spine. Neck pain and computer users are clearly connected due to extended periods of sitting in a certain position with no breaks to stretch the neck muscles. Prolonged computer use with neck bent forward will cause the anterior neck muscles to gradually get shorter and tighter, while the muscles in the back of neck will grow longer and weaker. These changes will lead to development of neck pain. Neck problem also accounts for a large proportion of occupational illness and disability. Neck pain is common among computer workers in our country and contributes importantly to the demand for medical services and the economic burden of absence from work due to sickness.

The main purpose of this randomized clinical trial will be to find out the effects of Isometric exercises with and without Pressure Biofeedback Unit on Cervical pain and Muscle strength in Computer users with cervical spine overload. Patients will be recruited in the study by convenient sampling technique after that will be allocated to groups by simple random assignment with an inclusion criteria having chronic neck pain for more than 3 months, current pain level ranging greater than 3 on NPRS, patient with minimum and moderate disability and male and female computer users with age 25 to 40 years with cervical pain. Patients with history of cervical trauma, postural deformity, spinal cord deformity, current pregnancy and significant neurological deficits were excluded.

Numeric Pain Rating Scale (NPRS) and Neck Disability Index (NDI) will be used to measure before and after treatment session. Treatment will be given to both groups for 4 weeks and each group will receive 3 sessions per week. After collecting the data it will entered and analysed using Statistical Package for the Social Sciences (SPSS) version 25. Data will be assessed by using parametric/ non parametric test after completion of the study.


Eligibility Criteria:
Inclusion Criteria:

* Aged between 20-40 years among male and female with cervical pain
* Having chronic pain for more than 3 months.
* Current pain level ranging greater than 3 on NPRS
* Patients with minimum and moderate disability based on NDI

Exclusion Criteria:

* History of cervical trauma
* Postural deformity
* Spinal cord deformity ( scoliosis, kyphosis, lordosis)
* Current pregnancy
* Significant neurological deficits ( cervical radiculopathy, cervical spondylosis)
Efficacy and Safety Study of Endoscopic Submucosal Dissection for Early Gastric Cancer

The purpose of this study is to evaluate the safety and clinical effectiveness of ESD(Endoscopic Submucosal Dissection) for early gastric cancer analyzing short-term and long-term results of endoscopic treatment.

Traditionally open-gastrectomy is the standard treatment for gastric cancer without distant metastasis, but high mortality and morbidity, the intense weight loss, food intake difficulties after surgery are fraught, including problems with the drawback of significantly degrading the quality of life. Therefore, a lot of effort to seek the more simple treatment than open gastrectomy has been made, recently the endoscopic treatment for early gastric cancer is the most widely used treatment.

This single-arm, multi-center study enroll early gastric cancer patients after ESD compared with the retrospective control(surgical treatment) group considering the unreality of the randomized clinical trials. In addition, the quality of life assessment by the EORTC C30/STO22 tools before and after ESD procedure in enrolled patients will be performed and the direct cost analysis also will be conducted.

Eligibility Criteria:
1. ESD GROUP

   Inclusion Criteria:
   * Korean people aged \>=20 years
   * Endoscopic Grossly the lesion diameter ≤ 3cm
   * Endoscopic biopsy results: Well-differentiated and moderately differentiated adenocarcinoma
   * No ulcers in lesions
   * Endoscopic biopsy results: In case of gastric cancer, no metastasis in CT test performed before ESD procedure

   Exclusion Criteria:
   * Subject with history of malignant disease in other organs
   * Subject with history of stomach surgery due to peptic ulceration etc.
   * As the cases of an absolute contraindication of general anesthesia; Subject with chronic liver disease over Child score B, Subject with chronic Renal Disease requiring hemodialysis or peritoneal dialysis, Subject with heart failure more than Ⅲ score according to New York Heart Association Classification, Subject with severe systemic diseases such as respiratory disease
   * Subject with Bleeding tendency
   * Pregnant woman or woman with possibility of pregnancy
   * Subject who cann't be obtained informed consent
   * Subject who is unable to follow up for any other reason
2. Surgery Group(Retrospective data collection)

Inclusion Criteria:

* Subject with gastric laparoscopy or open-surgery for treatment early gastric cancer during 2002.1.1 \~2004. 12. 31
* Korean people aged \>=20 years
* Early gastric cancer confirmed by pathology during gastric surgery; Gastric cancer confirmed to the mucosal or submucosal regardless of lymph node metastasis
* No history of malignant disease in other organs
* No history of stomach surgery due to peptic ulceration etc.
Botulinum Toxin Injection Efficiency

The purpose of the study is to examine the effect of the botulinum toxin injection into muscle tone, strength and mobility with and without muscle exercise effect.

The purpose is also to find out patients subjective symptoms between injections. Hypothesis: Efficiency of the botulinum toxin is more powerful with the muscle exercise before injection.

Eligibility Criteria:
Inclusion Criteria:

* Clinical diagnosis of cervical dystonia
* Spasticity in splenius capitis muscle
* Regular treatment with botulinum toxin injection

Exclusion Criteria:

* Don't want to take part the Trial
* Very long distance from home to Jyväskylä Central Hospital
Faecal Microbiota Analysis in Neurotypical and Autism Syndrome Disorder Siblings

This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings. In addition it aims to also characterise the metagenome and metabolome of the faeces of both ASD and neurotypical siblings.


Eligibility Criteria:
Inclusion Criteria:

* Children of both sexes who are diagnosed with ASD and under the care of ESNEFT who have a neurotypical sibling (either full or half sibling), who share their living environment. This is due to the study requiring stool samples that are from siblings, to control for genes and environment where possible.
* Aged 3 years to 10 years old (at time of consent)
* Parent/guardian able to consent to participate
* Parent/guardian able to complete required surveys (or with accommodated adjustments)

Exclusion Criteria:

* Use of antibiotics in the previous 4 weeks
* Not under the care of ESNEFT
* Children \<3 years old and \>10 years old
* Children that don't have half or full siblings
* Parent/guardian unable to provide informed consent or complete surveys, despite reasonable adjustments being implemented
Cochlear Implants in Post-lingually Children: Results After 10 Years

Objectives: To assess a group of post-lingually children after 10 years of implantation with regard to speech perception, speech intelligibility, and academic/occupational status.

Study Design: A prospective transversal study. Setting: Pediatric referral center for cochlear implantation. Patients: Ten post-lingually deafened children with Nucleus and Med-El cochlear implants.

Interventions: Speech perception and speech intelligibility tests and interview.

Main Outcome Measures: The main outcome measures were score of Hint sentences recognition (silence and noise), speech intelligibility scores(write-down intelligibility and rating scale scores) and academic/ occupational status.


Eligibility Criteria:
Inclusion Criteria:

* postlingually deaf
* age at cochlear implant: \< 18 years
* more than 10 years of cochlear implant use

Exclusion Criteria:

* other disabilities
Impact of Professional Societies' Recommendations on Practical Use of Hormone Replacement Therapy

This study is conducted in Europe. The aim of this study is to verify the therapeutic effects of low-dose hormone replacement therapy (HRT) in female patients over adequately long time period in normal clinical practice conditions in the Czech Republic.


Eligibility Criteria:
Inclusion Criteria:

* Post-menopausal
Advancing HIV Prevention and Linkage to Care Among MSM With Gamification

This study is a pilot evaluation of 'Stick To It', a behavioral intervention based on the concept of gamification. The objective of the program is to encourage young men who have sex with men (MSM) to be regularly screened for HIV and sexually transmitted infections (STIs) and to adopt safer sexual behaviors, with the ultimate goal to decrease HIV and STI incidence. Gamification is the application of game elements, like points, badges, and rewards, to non-game settings.

The investigators will conduct a quasi-experimental pilot study of 'Stick To It', a prevention intervention that uses gamification principles and mechanics. The intervention includes an online timer that reminds men to get tested, online quizzes, and peer recruitment; these activities are awarded with points redeemable for chances at prizes at participating clinics. The intervention was designed based on findings from interviews with health staff and focus groups with young MSM, and with input from a gamification consultant. The primary hypothesis is that the intervention will increase repeat HIV/STI testing among young MSM. The intervention will be implemented at two STI clinics in Oakland and Los Angeles, California in 2-week intervals for six months. The investigators will review medical records of exposed and unexposed young MSM attending the same STI clinics to compare uptake of quarterly HIV testing and self-reported behavior after six months.

Eligibility Criteria:
Inclusion Criteria:

* 18-26 years of age
* male
* self-identify as gay / bisexual / queer
* willing and able to provide informed consent to join the Stick To It program
* resident in one of several zip code areas surrounding the clinic

Exclusion Criteria:

* Not a resident of one of included zip code areas
A Study of Fixed Dose Versus Serum Level-Based Titration Regimen of Vitamin D Supplementation in Dialysis Patients

Vitamin D insufficiency, defined as serum 25-hydroxyvitamin (OH) D level less than 30 ng/ml, is highly prevalent not only in the general population but also in chronic kidney disease (CKD) population. Many guidelines including the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) have consistently recommended vitamin D supplementation in patients with pre-dialysis CKD with vitamin D insufficiency with ergocalciferol or cholecalciferol to achieve 25(OH)D level of more than 30 ng/ml using serum levels-based titration regimen. However, this protocol has not been studied in end stage kidney disease patients treated with maintenance dialysis.

The investigators plan to conduct a randomized study comparing the two different protocols between serum 25(OH)D level-based titration regimen and fixed dose of ergocalciferol supplementation among dialysis patients for a total period of 6 months. At the study completion, investigators also plan to compare the proportion of participants achieving serum 25(OH)D of more than 30 ng/ml, CKD-related metabolic and bone parameters as well as non-skeletal effect of vitamin D supplementation for each group.

Eligibility Criteria:
Inclusion Criteria:

* age \> 18 years
* on maintenance dialysis (hemodialysis or peritoneal dialysis) \> 3 months
* 25(OH)D \< 30 ng/ml
* able to provide inform consent form

Exclusion Criteria:

* current ergocalciferol or cholecalciferol treatment
* known allergy to ergocalciferol
* active inflammation or infection
* advanced stage of cancer
* pregnancy
* lactation
* on immunosuppressive drugs or corticosteroids
Chronic Constipation in Children Among School Children is Assuit University Children Hospital

Aim of the work to show rate of constipation among school age children in Assuit University Children Hospital

Childhood constipation is a frequently overlooked global health problem, which is developing in a public health issue in many parts of the world.(1) Constipation is one of the commonest digestive complaints in children(2) Constipation has long been considered a symptom, rather than a disease(3)

It is often perceived as infrequent motions or passage of hard stools. Some defined constipation as less than 3 bowel motions per week)4(

or as difficulty in passing stools (5) Approximately 0.5% of school children have defecation frequency less than 3 per week and 0.3% have fecal incontinence(6) Furthermore, 20% of children also have at least 1 clinical feature of constipation.7 Therefore, it is important to use diagnostic criteria based on multiple symptoms to define constipation

Eligibility Criteria:
Inclusion Criteria:school age children 4:18 years old -

Exclusion Criteria: neonates and younger than 4years children

-
Leveraging an Existing Large-scale Safe Water Program to Deliver Nutrition Messages at a Low Marginal Cost

The investigators are seeking to overcome the dual challenges of under-nutrition and diarrhea using an existing safe water supply platform to deliver nutrition information to targeted groups in Western Kenya. Using a randomized evaluation, investigators will determine the impact on nutrition status and practices of delivering nutrition information. The evaluation results will enable Evidence Action to make strategic decisions regarding the potential scale-up of the combined program across Kenya.

Evidence Action's Dispensers for Safe Water program currently provides access to safe water for two million people. The program would be able to leverage the existence of this service delivery platform to provide promoters with training on proper nutrition and methods for delivering these messages to target groups.

The intervention is a home visiting program that will provide nutrition advice on complementary feeding to households with children aged 6-24 months. Two types of home visits will be evaluated, a 'traditional visit mode' in which the child's mother receives the visit; and a 'couples visit mode' in which the promoter attempts to involve both the father and mother.

Households in the control group will also receive home visits by promoters but the content of the visit will be restricted to safe water. The same information on safe water will also be provided to households in the treatment group. Hence, the evaluation will measure the additional effect of providing nutrition information on top of information on safe water.

Promoters will provide advice on nutrition and food hygiene to target households, according to criteria established by Evidence Action. Following the Guiding Principles for Complementary Feeding of the Breastfed Child (PAHO/WHO 2003), the intervention will include information on the maintenance of breastfeeding, safe/hygienic preparation and storage of complementary foods, amount of complementary food needed, food consistency, meal frequency and energy density, nutrient content of complementary foods, and feeding after illness. The home visits will be modelled on the MaiMwana Infant Feeding intervention (http://www.maimwana.malawi.net/MaiMwana/Home.html) that has been taking place in Mchinji (Malawi) since 2005.

Households within the treatment group will be provided by a poster to hang in their dwellings with some basic information on nutrition. A random subset of households will be given a small poster in black and white, and the other subset of households will be give a larger color poster.

Eligibility Criteria:
Inclusion Criteria:

* Children will be included if they are between 0 and 18 months at baseline and live within the catchment area of a water point in which Evidence Action installs a chlorine dispenser

Exclusion Criteria:

* None
Psychological Factors Influencing Cancer Post-traumatic Growth

The study focuses on post-traumatic growth (positive changes linked to appreciation of life, personal strengths, social relationships...) in the context of different types of cancer and with a longitudinal approach to the care pathway. The aim of the study is to better understand whether psychological variables (emotional competence, psychological flexibility, psychological distress) and patients' care satisfaction, assessed at the start of the cancer treatment pathway, can influence their post-traumatic growth at the end of the chemotherapy protocol and 6 months later.


Eligibility Criteria:
Inclusion Criteria:

* Patients over 18 years of age
* Patients in the initial phase of curative treatment for a 1st solid cancer
* At the start of neo-adjuvant or adjuvant chemotherapy (1st course or 2nd course)
* At less than 6 months from the initial diagnosis
* Patient having given written consent to participate in the study

Exclusion Criteria:

* Patients with a previous history of cancer
* Patients with incurable cancer progression, recurrence or relapse
* Metastatic, brain, hematological or skin cancer
* Patients who have difficulty understanding written French
* Patient psychologically or physically unable to answer questionnaires
Cardiovascular Biorepository

Use biospecimens procured from patients and organ donors to improve understanding of molecular, cellular, and tissue-level processes produced by cardiovascular disease and therapeutic interventions

This is a prospective evaluation of patients undergoing cardiovascular procedures at the University of Kentucky Medical Center.

Eligibility Criteria:
Inclusion Criteria:

* All patients undergoing cardiovascular surgery/procedure at the University of Kentucky who are at least 18 years of age