cyrilzakka/clinical-trials huggingface dataset:
Washed Microbiota Transplantation for Malnutrition

Malnutrition is a pathological condition in which dietary intake fails to meet the body's energetic or nutritional needs. It may be caused by macronutrient or micronutrient deficiencies, high energy expenditure, impaired nutrient absorption or assimilation. Malnutrition can affect all stages of life. In adults, malnutrition is strongly associated with poor clinical outcomes such as increased morbidity, increased mortality and prolonged hospitalization. In children, malnutrition can lead to growth retardation, cognitive impairment and immune dysfunction.

The gut microbiota of malnourished patients is different from that of healthy people. The diversity of the gut microbiota of patients with severe malnutrition reduced and the abundance of Proteobacteria significantly increased, as well as pathogenic genera such as Klebsiella, Escherichia coli, Shigella, and Streptococcus. This suggests that gut microbiota plays an important role in the occurrence and development of malnutrition. Dietary intervention targeting gut microbiota can quickly improve children's malnutrition, promote weight gain and increase protein levels that promote bone growth and nerve development. Exclusive enteral nutrition combined with immediate washed microbiota transplantation(WMT) can rapidly improve the nutritional status of patients with Crohn's disease compared with those with delayed WMT. Gut microbiota has been confirmed to be closely related to malnutrition. Improving the disordered gut microbiota in malnourished patients may become a potential treatment.

Eligibility Criteria:
Inclusion Criteria:

1. Age ≥18 years old;
2. Meet any of the following two conditions: ①weight loss (\>5% weight loss in the past 6 months or \>10% weight loss in more than 6 months); ②low BMI (\<70 years old and BMI\<18.5kg/m2 or ≥70 years old and BMI\<22kg/m2);
3. Underwent washed microbiota transplantation.

Exclusion Criteria:

1. Expected survival time \<3 months;
2. Women who are pregnant or breastfeeding;
3. Other patients deemed not suitable for enrollment by the investigator.
Fu's Subcutaneous Needling Treatment for Biceps Tendinopathy

Biceps tendinopathy is a common cause in shoulder-pain symptoms. The major mechanism is overuse of the biceps muscles. The long-term accumulated and poor repaired trauma causes myofascial trigger points in the related muscles.We will conduct the randomized, open label experiment to evaluate the immediate, short-term, and long-term effect of Fu's subcutaneous needling (FSN).

Biceps tendinopathy is a common cause in shoulder-pain symptoms. The major mechanism is overuse of the biceps muscles. The long-term accumulated and poor repaired trauma causes myofascial trigger points in the related muscles. Common symptoms are pain in the anterior shoulders and radiating pain in the biceps. Pain can be further elicited with lifting, pulling and repetitive overhead activity. Therefore, it can have a major impact on the patient's activity of daily life.

Fu's subcutaneous needling (FSN), as one of the dry needle treatments, performed by swaying a disposable Fu's subcutaneous needle parallel to the underlying muscles after penetrating the skin to the subcutaneous fascia. With the reperfusion activities, myofascial pain and soft tissue pain caused by myofascial trigger points can be decreased effective simultaneously. So far, there is no solid research or clinical trial to evaluate the efficacy of the treatment yet.

We will conduct the randomized, open label experiment to evaluate the immediate, short-term, and long-term effect of FSN. Outcome measures include visual analog scale, shoulder pain and disability index, pressure pain threshold, muscle tone changes and ultrasonographic evaluaton of biceps peritendinous effusion.

Eligibility Criteria:
Inclusion Criteria:

1. Subjects older than 20 years of age who can cooperate with the experimental volunteers.
2. Suffering from biceps tendon lesions for more than one month, and subjective pain intensity (VAS) greater than 5 points.
3. There is a local tender point in front of the shoulder, and the shoulder joint pronation test can induce pain.
4. Under soft tissue ultrasound, the thickness of biceps peritendinous effusion (BPE) on the affected side of the biceps tendon is greater than1 mm.

Exclusion Criteria:

1. There are contraindications to general treatment, such as serious medical problems, recent serious trauma, or pregnant women.
2. There has been a history of drug abuse (including excess alcohol) that affects pain assessors.
3. Have received shoulder, neck or upper back surgery.
4. People with central or peripheral nerve disease.
5. Cognitive impairment, unable to cooperate with the experimenter.
6. Patients currently receiving other treatments for biceps tendinopathy.
7. Patients receiving shoulder injection treatments within the last 6 months.
8. Patients with rheumatic diseases.
Randomized Study Comparing Periodic Acceleration Versus Static Position in Cerebrovascular Stroke Patients

Stroke is one of the leading causes of death and disability worldwide. More than 85% of strokes are due to blood vessel occlusion resulting in partial destruction of the brain parenchyma. Current protocols try to re-establish blood circulation as soon as possible through chemical and/or mechanical interventions but new strategies are needed.

Periodic acceleration (pGz) is a non-invasive method consisting in the application of a rocking movement to the patient that ultimately will induce the release of beneficial chemicals from the vascular endothelium (the cells lining the inside of the blood vessels). Application of pGz in an animal model of stroke resulted in a dramatic reduction of associated brain damage.

This trial will investigate whether stroke patients exposed to pGz experiment significantly higher recovery than patients that remained static during their treatment.

Periodic acceleration (pGz) is a non-invasive method consisting in the application of a rocking movement to the patient that ultimately will induce the release of beneficial chemicals from the vascular endothelium (the cells lining the inside of the blood vessels). Application of pGz in an animal model of stroke resulted in a dramatic reduction of associated brain damage.

This trial will investigate whether stroke patients exposed to pGz experiment significantly higher recovery than patients that remained static during their treatment.

Eligibility Criteria:
Inclusion Criteria:

* A signed informed consent form must be obtained prior to recruitment
* Patients with symptoms of acute ischemic stroke
* Less than 12 hours from initiation of the stroke
* Age: 18 years or older
* Capable of following the protocol

Exclusion Criteria:

* Pregnant or lactating women, and women that do not follow a contraceptive plan and may become pregnant
* Less than 18 years of age
* More than 12 hours from the initiation of the stroke or when the initiation time is unknown.
* Hemorrhagic stroke
* Candidates to receive thrombolytic treatment
* Spine traumatism or other conditions that may be aggravated by pGz
* Patients that cannot be properly followed because of phycological, social, familiar, or geographical reasons.
Self-Management Supported Telerehabilitation in Children and Adolescents With Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of unknown etiology in childhood. JIA covers several different subgroups and is predominantly manifested by peripheral arthritis. Joint swelling, effusion, tenderness, pain in JIA; causes functional limitations, fatigue and quality of life disorders. Chronic inflammation limits the patient's daily activities and productivity. Self-management is defined as an individual's ability to manage their symptoms, treatment, lifestyle changes, and the psychosocial and cultural consequences of health conditions. Good self-efficacy and coping skills reduce the health and financial burden on the individual as well as on health care, benefiting society in general. Telerehabilitation is the dissemination of rehabilitation services through communication technologies. In the literature, it is seen that the studies on internet-based exercise applications are limited. In the studies, people were encouraged to physical activity with an internet-based application and the benefits of being active were given within the scope of patient education, and it was reported that the level of physical activity effectively improved as a result. It can also increase endurance, has been reported to be safe and feasible. In our study, unlike the literature, the self-management program and exercise applications will be integrated into the internet-based telerehabilitation method, based on the fact that the exercise practices in JIA are effective in disease management and improvement of symptoms. Therefore, in our study; the effectiveness of telerehabilitation-based exercise methods to be applied additionally synchronously and asynchronously to self-management education in children and adolescents with JIA on pain, disease activity, functional status, fatigue, quality of life, psychosocial status, self-efficacy and satisfaction will be examined and compared.


Eligibility Criteria:
Inclusion Criteria:

* Having been diagnosed with Juvenile Idiopathic Arthritis according to ILAR diagnostic criteria
* 8-18 years old
* Agreeing to do the exercises throughout the study
* Stable symptoms and medications
* Internet and computer access

Exclusion Criteria:

* Be younger than 8 years old
* Surgical or arthroscopic operation in the last 1 year
* Having any musculoskeletal disease or orthopedic, neurological, psychological disease that may prevent participation in exercise
* Presence of active synovitis and arthritis
* Active vestibular disease
* Family and patient's inability to adapt to the assessment
* Having a psychiatric illness that affects cooperation
* Having heart failure and lung pathology at a level that will affect activities of daily living
Ultrasound to Predict a Pediatric Difficult Airway and Obstructive Sleep Apnea Syndrome in Children

This is a prospective study to see whether ultrasonography can predict difficult airway and/or predict obstructive sleep apnea syndrome (OSAS) in children.


Eligibility Criteria:
Inclusion Criteria:

* Children with known or suspected difficult direct laryngoscopy identified by either ENT or anesthesiologist.
* Children with difficult tracheal intubation aged 1 month - 18 years old
* Children with obstructive sleep apnea aged 1 year - 8 years old

Exclusion Criteria:

* Parent/ patient refusal to participate in study
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)

This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease. A four-week pilot study will first evaluate the CogState computerized cognitive battery in participants who are not receiving treatment. After completion of the pilot study, participants will be randomized to receive Placebo, Donepezil 5 mg, MK-0249 7.5 mg, and MK-0249 25 mg. After each drug administration the participants will be given the CogState computerized cognitive battery to assess cognitive performance. The primary hypotheses are that cognitive performance in participants with Alzheimer's disease, or in healthy participants, is improved by the administration of a single oral 5 mg dose of Donepezil as compared to placebo.


Eligibility Criteria:
Inclusion Criteria:

Patient Specific:

* Female is not of reproductive potential
* Male who has a female partner(s) of child bearing potential, agrees to use acceptable method of contraception during the study
* Has at least 10 years of education or work history
* Has been a nonsmoker or has not used nicotine for at least 6 months
* Has a diagnosis of mild-to-moderate Alzheimer's Disease
* Has a reliable caregiver who consents to accompany the patient to all clinic visits, provide information to the study staff, and return for follow-up visits and procedures

Healthy Elderly Volunteer Specific:

* Is in good general health
* Has no clinically significant abnormality on electrocardiogram (ECG)

Exclusion Criteria:

Participant Specific:

* Has a history of a neurological disorder other than Alzheimer's disease
* Is living in a nursing home
* Has a history of stroke
* Has a history of psychotic disorder, an active major depressive disorder, or history of schizophrenia
* Has a history of a sleep disorder
* Has a history of a cardiovascular disorder
* Has a history of malignancy
* Is participating or has participated in a study with an investigational compound, device, or vaccine for Alzheimer's disease
* Consumes greater than 6 servings of caffeine (coffee, tea or cola etc.) per day
* Consumes greater than 3 alcoholic beverages per day
* Has had major surgery, donated or loss blood in past 8 weeks

Healthy Elderly Volunteer Specific:

* Is mentally or legally incapacitated, has significant emotional problems, or has a history of a psychiatric disorder over the last 5-10 years
18F-FDG-PET Guided Dose-Painting With Intensity Modulated Radiotherapy in Oropharyngeal Tumours

Treatment of cancers of the head and neck, including oropharyngeal tumours, usually consist of a combination of radiotherapy and chemotherapy, although surgery may also play a part. Radiotherapy works by using the high energy x-rays to destroy cancer cells. Head and neck cancers often respond well to radiotherapy in the first instance and a proportion of patients will be cured by this treatment. However, not all of the cancer cells are destroyed by the combination of radiotherapy and chemotherapy and, in some patients, the cancer does come back.

Studies have suggested that more efficient killing of cancer cells, and therefore, better cure rates, can be achieved by increasing the radiotherapy dose. However, in the past, this was not possible due to side effects. Intensity Modulated Radiotherapy (IMRT) is a new radiotherapy delivery technique that allows better shaping of the dose to the areas that need irradiating with the potential for fewer side effects. If the investigators use IMRT to deliver an intentionally higher dose of radiation (called a boost) to small selected areas whilst, at the same time giving standard treatment doses to the remaining areas, this approach is called IMRT dose-painting. These selected areas can be identified by a scan called 18F-FDG-PET (18F-fluorodeoxyglucose-positron emission tomography, also known as a 'PET' scan) which is a type of scan that can give information about the activity of a cancer.

The purpose of this study is to find out whether the investigators can use IMRT dose-painting to boost the dose to the region inside a tumour which appears most active on 18F-FDG-PET. If this study shows that this approach is well-tolerated, then the investigators may be able to improve cure rates with this treatment. This would need to be tested in a subsequent study.


Eligibility Criteria:
Inclusion Criteria:

* Histologically confirmed squamous cell carcinoma (SCC) of the oropharynx assessed as either HPV negative or HPV positive with greater than 10 pack year smoking history and N stage at least N2b, to be treated with primary radical neoadjuvant chemotherapy followed by chemo-intensity modulated radiotherapy (chemo-IMRT) to the primary and bilateral neck nodes
* Age ≥ 18 years.
* ≥T2 tumours.
* Staging 18F-FDG-PET/CT showing adequate uptake at the level of the primary tumour.
* WHO performance status 0-2.
* Renal function adequate for cisplatin chemotherapy.
* All patients must be suitable to attend regular follow-up.
* Written informed consent must be obtained in all patients.

Exclusion Criteria:

* Previous radiotherapy to the head and neck region interfering with the protocol treatment plan.
* Previous malignancy except non-melanoma skin cancer.
* Previous or concurrent illness, which in the investigators opinion, would interfere with either completion of therapy or follow-up.
Using Mobile Technology to Promote Physical Activity

The purpose of this study is to test an intervention which uses a personalized mobile-technology based approach that aims to promote physical activity and reduce sedentary behaviour in inactive working Singaporean adults.

Considering the increasing burden in type 2 diabetes mellitus and other chronic diseases, the promotion of physical activity and reduction of sedentary behavior have an important role to improve population health.

Primarily, potential participants will be identified and recruited among participants from the Singapore Health Study (SHS) 2014 based on pre-specified selection criteria . SHS is a cross-sectional study of adults between 18 and 79 years which is conducted annually to monitor health, health behavior and health determinants among the Singapore general population.

All eligible participants will be randomized with a 1:1 ratio to intervention and control group.

Intervention group participants will receive a personalized mobile-technology based intervention to promote physical activity. It consists of four components:

1. General physical activity educational materials
2. Wearable activity tracking devices to enable the intervention participants to self-monitor their physical activity behavior and receive real-time feedback
3. Access to an online map of Singapore providing location based information about leisure time physical activity opportunities
4. Personalized text messages which include, educational information, tailored theory-based motivational messages, as well as compliance enhancing reminders

Control group participants will receive general physical activity educational materials, identical in content to that of the general educational materials of intervention group participants.

All participants will be assessed at baseline, 6 months and 12 months after the intervention by accelerometry and self-reported questionnaires.

Eligibility Criteria:
Inclusion Criteria:

* Men and women 25 to 65 years of age
* Physically inactive
* Working full-time for at least one more year after inclusion
* Signed written informed consent for the intervention study
* Willing to wear the activity tracker, fitbit all the time every day for 6 months

Exclusion Criteria:

* severe medical conditions prohibiting participation in physical activity
* pregnant women
* insufficient English language skills
* Participants who have already activity tracker device
Effect of a Mental Wellness App on the Mental Wellness of Medical and Nurse Anesthesia Students

Mental health issues and suicide are becoming increasingly common among health care trainees and providers. Suicide is the leading cause of death among male medical residents and the second leading cause of death among female residents.

Training programs are usually very rigorous, caring for patients is stressful, and those who care for others often feel that they can't or shouldn't admit that they need care themselves. Unfortunately, there is often a stigma associated with mental illness, and trainees may feel that admitting that they struggle could damage their careers. The need exists for easily accessible, immediate, crisis support for medical trainees who are experiencing a mental health crisis. Although the effectiveness of mental health apps has been evaluated in college students, there is very little data assessing their use in medical and nurse anesthesia students. The purpose of this study is to evaluate the effect of a mental wellness app on the mental wellness of medical and nurse anesthesia students.

Eligibility Criteria:
Inclusion Criteria:

* first-year medical students and second-year nurse anesthesia (CRNA) students from Wake Forest University School of Medicine during the 2023 - 2024 academic year (approximately July 2023 - June 2024).

Exclusion Criteria:

* none
Colorectal Cancer Screening for Cancer Survivors

The risk of colorectal cancer (CRC) is significant among cancer survivors treated with abdominal radiation therapy (RT). Further, CRC is once of the few cancers for which there is effective screening. Although some expert groups recommend early CRC screening for patients with prior abdominal RT, the effectiveness of early screening is unknown. It is also unknown if radiation-induced CRC passes through a "pre-clinical" phase in which precancerous polyps are detectable and treatable prior to becoming invasive cancers. This study will evaluate whether screening will detect pre-invasive colorectal polyps among survivors treated with RT.

Cancer survivors meeting the COG criteria for CRC screening will undergo colonoscopy and removal of colorectal polyps. Documentation of polyp number, location and pathologic characteristics will be made. Clinical data information will also be collected at the time of patient enrollment.

Eligibility Criteria:
Inclusion Criteria:

1. Asymptomatic survivors treated with ≥ 25Gy to the abdomen, pelvis or spine, or ≥ 12Gy total body radiation therapy, or ≥ 12Gy whole abdominal RT.
2. Patients who have passed ≥10 years following RT
3. Patients whose current age is 35-49.

Exclusion Criteria:

1. Patients with signs/symptoms suggestive of CRC or other high-risk features such as:

   * Persistent constipation for \>2 weeks in the last month
   * One or more unexplained episodes of red blood in the stool in the last month
   * One or more unexplained episodes of black stool in the last month
   * Unexplained pelvic pain in the last month
2. Patients with a history of Crohn's disease or ulcerative colitis
3. Patients already taking part in a colorectal screening program defined as any colorectal screening (colonoscopy, sigmoidoscopy, fecal occult blood test) within last 5 years.
4. Patients with self-reported history of colorectal polyps.
Immersive v/s Non-immersive Virtual Reality in Enhancing Upper Limb Functions Among Individuals With Subacute Stage Hemiplegia

The goal of this randomized controlled trial is to compare the effectiveness of immersive virtual reality combined with conventional therapy to the effectiveness of non-immersive virtual reality combined with conventional therapy in enhancing upper limb function in subacute hemiplegic stroke patients.

The study is a single blinded randomized controlled trial in which the assessor will be blinded. Male and female participants aged between 28-55 years are included in the study. Participants are selected based on inclusion and exclusion criteria and are later randomly assigned to Group 1 and Group 2.

Group 1 - Conventional therapy and Immersive Virtual Reality Group 2 - Conventional therapy and Non-Immersive Virtual Reality

Primary Outcome measures include the Fugl Meyer Assessment for Upper limb and Graded Wolf Motor Function test for upper limb.

Secondary Outcome measure is the Stroke Specific Quality of Life Scale (SS-QOL) Questionnaire.

Therapy session starts with 15 minutes of stretching and strengthening exercises of the affected arm followed by 45 minutes of Immersive / Non Immersive virtual reality training.

Follow up assessment is done 6 weeks post intervention.

The baseline assessment score and follow up assessment scores will be compared.

Eligibility Criteria:
Inclusion Criteria:

* Individuals aged 28-55 years.
* Diagnosed with hemiplegia due to stroke.
* ≤ Grade 2 on Modified Ashworth scale.
* ≤ Stage 2 on Brunnstrom stages of motor recovery.
* Score of ≥ 35/36 on Cognitive assessment scale for stroke patients (CASP)

Exclusion Criteria:

* Contraindications for VR therapy, such as severe motion sickness or photosensitive epilepsy, impaired spatial awareness.
* Pre-existing neurological conditions such as spinal cord injury, Multiple sclerosis and so affecting upper limb function.