cyrilzakka/clinical-trials huggingface dataset:
A Comprehensive Approach to Secondary HIV Prevention and Care Among Positives

The goal of this study is to conduct an HIV prevention intervention to train HIV seropositive drug users to be peer health educators.

The primary objective of this funded research is to conduct an HIV prevention intervention to train HIV seropositive drug users to be peer health educators to: (1) recruit their high risk social network members for voluntary HIV counseling and testing (VCT) at the research clinic, (2) promote risk reduction among social network members, and (3) promote engagement in HIV care by encouraging HIV seropositive network members to schedule and keep HIV primary care appointments. There will be four types of participants in the Full Trial: 1) Index, 2) Testing Network 3) Longitudinal Network and 4) HIV positive network participants. This longitudinal study includes baseline, 6-months, and 12-month assessments

Eligibility Criteria:
Inclusion Criteria:

Index

1. 18 years old or older
2. documentation of HIV positive status
3. report one of following risk behaviors in past 90 days: sharing injection equipment, use of crack cocaine, or unprotected vaginal or anal sex

Testing network

1. 18 or older
2. provided testing coupon provided by an index participant

Longitudinal network participant-

1. tested HIV negative at the Lighthouse via redeeming a testing coupon
2. reported interacting with index who gave the coupon at least weekly
3. report one of following risk behaviors in the prior 90 days: sharing injection equipment, use of crack cocaine, or unprotected vaginal or anal sex

Positive Networks

1. HIV positive
2. report one of following risk behaviors in the prior 90 days: sharing injection equipment, use of crack cocaine, or unprotected vaginal or anal sex

Exclusion Criteria:

Index- already enrolled in the study as a Network participant

Testing network- already enrolled in the study as a Network participant

Longitudinal network- a) already enrolled in the study as a Network participant b) already enrolled in the study as a Index participant

Positive network- a) already enrolled in the study as a Network participant b) already enrolled in the study as a Index participant
Vaccination for Children of H&O and Their Parents

The purpose of this study is to study on compliance, safety and effectivity of vaccination for children with hematologic malignancies or solid tumors and their parents.

Children with hematologic malignancies or solid tumors are all facing with immune deficiency due to the disease, the chemotherapy, the hematopoietic stem cell transplantation or the splenectomy, which greatly increases their chance to get infectious diseases. In this study, we will assess the compliance of children with hematologic malignancies or solid tumors and their parents to accept vaccination after finishing treatments, follow up with untoward effect questionnaires to assess the safety, obtain the serum of children patients to test antibody titers and assess the effectivity, provide clues for the study of vaccination in children with hematologic malignancies or solid tumors and provide a scientific basis for the formulation and reunification of vaccination programs.

Eligibility Criteria:
Inclusion Criteria:

1. Children patients(≤18 years) who accepted chemotherapy, hematopoietic stem cell transplantation or splenectomy since our study started.
2. No history of hepatitis B and measles, do not suffer from other diseases that affect immune function and allergic diseases.

Exclusion Criteria:

1. Children patients who did not reach clinical remission after treatment, critically ill or eventually died.
2. Patients who used monoclonal antibodies, especially anti-tumor necrosis factors.
3. Intermittent or low-dose chemotherapy or other immunosuppressive drugs users.
Attentionnal Performance of Shift Health Workers in Emergency Department

Atypical working hours can be a risk factor for workers. In fact, the body is subject to a circadian rhythm, which affects numerous physiological activities. These biological rhythms reflect the need for certain physiological activities to occur at a specific time of day. This cycle can be disrupted and shifted by external factors. This disruption of biological rhythms can manifest itself in the appearance of health effects.

The innovative nature of our work lies in the search for an alteration in psychomotor functions in nursing staff (subject to atypical working hours). To this end, we decided to study the concentration of care workers using a reflex-based psychomotor test, the Psychomotor Vigilance Test (PVT). Other factors will be studied in order to assess the factors that may affect this test.

Population : All care staff in the emergency departments of the participating hospitals: physicians, residents, nurses and nursing assistants.

The main objective is to evaluate concentration in medical/non-medical staff at the start and end of a work shift.

To this end, we will evaluate the Psychomotor Vigilance Test (PVT) and its variation at the start and end of a shift in these personnel.

The endpoint is the difference in reflex time to a visual stimulus performed at the beginning and end of the shift with a 3-minute PVT Test.

The first secondary objective is to analyze the number of PVT errors. The criterion defining an error is a reaction time greater than 500ms.

The second secondary objective is to compare the PVT and its variation in certain subgroups. The subgroups compared will be defined according to the following criteria :

* Shift duration: Non-medical staff (\<10h, \>10h), Medical staff (6 to 10h, 10 to 15h, 15 to 24h) Staggered shift: start before 6h or end after 22h,
* Type of service: acute care, MCO, SSR (or emergency sector)
* Sleep quality (Pittsburgh Sleep Quality Index),
* Professional fatigue (Maslach Burnout lnventory),
* Anxiety (French official version of the PSS-14),
* Chronotype (Morningness-Eveningness Questionnaire).

Eligibility Criteria:
Inclusion Criteria:

* Physicians,
* residents,
* nurses,
* nursing assistants

Exclusion Criteria:

* Students,
* paramedics
Curcumin Supplement in Nonalcoholic Fatty Liver Patients

The purpose of this study is to investigate the effects of curcumin supplement on metabolic factors and hepatic fibrosis in nonalcoholic fatty liver patients with type 2 diabetes. Subjects will participate in 3 month, two group, randomized intervention, where one group (n=25) will take 1.5g/d curcumin and the other group (n=25) will take a placebo to compare differences in outcomes between the two groups.


Eligibility Criteria:
Inclusion Criteria:

* Patient diagnosed with type 2 diabetes based on ADA definition or who only take oral antidiabetic drug;
* CAP score \>263.

Exclusion Criteria:

* Taking any kind of antibiotics two weeks before recruitment;
* History of alcohol consumption;
* pregnancy or lactation;
* Professional athletes;
* Other liver disease (viral/etc);
* High dose synthetic estrogens, methotrexate, amiodarone, steroids, chloroquine, immunosuppressive drugs;
* A history of Cardiovascular disease;
* Renal disease, Celiac disease, Cirrhosis;
* History of Upper GI surgery;
* A history of hypothyroidism or Cushing's syndrome;
* History of drug dependence;
* Body mass index (BMI) ≥35 kg/m2;
* A restrictive diet or weight change ≥ 5 kg during the 3months prior to study;
* Any change in treatment with oral hypoglycemic; anti hypertensive and antilipid agents during the study;
* Use of weight loss medications.
Post Market Clinical Follow-up Investigation to Evaluate Performance and Safety on Pressure Ulcers, PU, When Using Exufiber as Intended

The primary objective of this post market clinical follow-up (PMCF) investigation is to evaluate performance and safety of Exufiber when used as intended in Stage II-IV pressure ulcers (PU).


Eligibility Criteria:
Inclusion Criteria:

1. Both gender ≥18 years old.
2. Subjects with Stage 2, 3 or 4 cavity pressure ulcer (acc to EPUAP)
3. Exuding pressure ulcer
4. Signed Informed Consent.

Exclusion Criteria:

1. Known allergy/hypersensitivity to the dressing.
2. Infected wounds, (2 signs of infection/local inflammation and a positive swab)
3. Stage 1 PU
4. Dry wounds
5. Subjects who will have problems following the protocol
6. Subjects included in other ongoing clinical investigation at present or during the past 30 days
A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy in Japanese Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-050)

This study will evaluate the effects of anacetrapib (MK-0859) on low-density lipoprotein-cholesterol (LDL-C) when compared to placebo in Japanese participants with heterozygous familial hypercholesterolemia when added to an existing statin lipid-modifying therapy.


Eligibility Criteria:
Inclusion Criteria:

* If female, cannot be of reproductive potential
* Diagnosed with heterozygous familial hypercholesterolemia
* Have been treated with an appropriate and

stable dose of statin± other lipid-lowering medication(s) for at least 6 weeks

Exclusion Criteria:

* Previously participated in a study with a cholesteryl ester transfer protein (CETP) inhibitor
* Homozygous familial hypercholesterolemia
* Severe chronic heart failure
* Uncontrolled cardiac arrhythmias, myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery by-pass graft (CABG), unstable angina, or stroke within 3 months
Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG

Patients complaining of tachycardia but with a negative Holter ECG, are for a limited time period offered a simplified electrophysiological(EP) examination. By a full electrophysiological study(EP study)electrodes are introduced for pacing and sensing i all four heart chambers. Where as by the mini invasive EP study only one electrode is introduced to the right atrium. The simplified procedure represent a smaller risk of complications, requires less resources but should yield the same diagnoses in more than 90% of the cases. The study is a feasibility study to see if the procedure can discover arrythmias in a fairly unselected patient population.

Sykehuset Telemark performs every year approximately 800 Holter ECG examinations. Approximately 200 of these are on the indications tachycardia, and in about 170 patients the examination does not discover any tachycardia Patients who were examined in the period from August 1. 2004 to November 1. 2005 with a negative Holter are mailed a letter with information of the min invasive electrophysiological examination, and an offer of volunteer participation. Patients given their informed consent are then according to waiting list called for the mini-invasive EP-study.

The protocol of the EP stimulation consists of: determination of pacing threshold, pacing with 8 asynchronous beats 600ms and an extrasystole with decremental intervals from 550 ms to 200 ms. The seri is repeated with pacing on 400ms and with two extrasystoles as well as with isoprenaline stimulation.

Eligibility Criteria:
Inclusion Criteria:

* History of complains of tachycardia
* No arrythmias detected by a 24 hours Holter ECG
* Age 19 to 74 years

Exclusion Criteria:

* Patients younger than 18 years
* Patients older than 75
Telephone Support During Overseas Deployment for Military Spouses

Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression. The goal is to help spouses learn ways to manage stress and solve problems related to deployment and reintegration, communication, managing long distance relationships, and other common problems. The study will compare telephone support groups to online education sessions. The study will enroll 160 spouses. In the Telephone Support groups, a group leader and participants will meet 12 times over six months to focus on education, skills building and support. Education Only online sessions will provide the same education content, without skills building or support. Content includes strategies to reduce or eliminate communication difficulties during deployment, how to find help; practical concerns during deployment; fostering resilience and decreasing stress; fostering relationships while apart, negotiating roles and relationships; changes during deployment; strategies to support the spouse and the service member; and cues to alert spouses when to seek mental health services for the family or themselves. Outcomes will include resilience, depression, anxiety and coping behaviors. Telephone data collection will be conducted at baseline, six and twelve months.


Eligibility Criteria:
Inclusion Criteria:

* spouse or significant other (living as married for at least one year before deployment) of an overseas deployed military service member
* deployed at least six months

Exclusion Criteria:

* living as married for at least one year before deployment
Methylprednisolone Replacement for Dexamethasone-induced Hiccup

Dexamethasone is a potent synthetic member of the corticosteroid. It is given to cancer patients undergoing chemotherapy to counteract emetic side effect and essential drug for the chemotherapy-treated patients. Hiccup is common adverse effect of corticosteroid especially on dexamethasone varying from 3% to 60% of given patients. Discontinuance of dexamethasone relieves most hiccupping cases, but vomiting/nausea rates increase. It is not clear whether hiccup side effect is limited to the dexamethasone only or other corticosteroid group.

Methylprednisolone, synthetic corticosteroid as similar as dexamethasone, could be considered as antiemetic agent for the patients with receiving chemotherapy. The investigators perform this pilot study under hypothesis that replacing dexamethasone with methylprednisolone could maintain antiemetic role and prevent hiccup.


Eligibility Criteria:
Inclusion Criteria:

* Age olderthan 21
* A Patient on chemotherapy who was diagnosed malignant tumor
* A Patient who is newly developed hiccup in the course of chemotherapy
* A patient with the willingness to comply with the study protocol during the study period and capable of ccomplying with it
* A patient who signed the imformed consent prior to the participation of the study and who understands that he/she has a right to withdrawal from participation in the study at any time without any disadvantages

Exclusion Criteria:

* A patient with history of uncontrolled seizures, central nervous system disorder or psychiatric disorders that are considered clinically significant by the investigator that would prohibit the understanding of informed consent or that may be considered to interfere with the compliance of the administration of the study medications
* A patient with uncontrolled diabetes
* A patient who developed uncontrolled serious infection or other uncontrolled serious concomitant diseases
* A patient with disease progression after run-in period who is expected to receive another chomotherapeutic agents with different level of emetic risk
The Safety and Efficacy of Escitalopram in Pediatric Patients With Major Depressive Disorder

Depression affects approximately 2.5% of children and 8% of adolescents. Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults. This study is designed to provide a systematic evaluation of the safety and efficacy of escitalopram in the treatment of depressed pediatric patients, 12 to 17 years of age. Patients completing the study will be eligible to enter an open-label extension study.


Eligibility Criteria:
Inclusion Criteria:

* Patient must meet Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) diagnostic criteria for Major Depressive Disorder.
* Patient's current depressive episode must be at least 12 weeks in duration
* Patient must have a parent or caregiver who must agree to accompany the patient to all clinic visits.

Exclusion Criteria:

* Patients who currently meet DSM-IV criteria for:

  1. attention deficit-hyperactivity disorder
  2. obsessive-compulsive disorder
  3. posttraumatic stress disorder
  4. bipolar disorder
  5. pervasive developmental disorder
  6. mental retardation
  7. conduct disorder
  8. oppositional defiant disorder
* Patients who are considered a suicide risk (have active suicidal ideation), who have made a suicide attempt, or who have ever been hospitalized because of a suicide attempt.
Living Alone is Predictive of Non-home Discharge Following Elective Total Hip Arthroplasty: a Matched-pairs Cohort Analysis

The goal of this observational study is to assess the effect of living alone on total hip arthroplasty thirty-day outcomes. The main questions it aims to answer are:

Is living alone associated with discharge disposition (home versus non-home)? Is living alone associated with greater incidences of secondary adverse events?

Participants will be sampled from the 2021 American College of Surgeons National Surgical Quality Improvement Program


Eligibility Criteria:
Inclusion Criteria:

* Elective, non-emergent cases
* Living alone
* Living with others

Exclusion Criteria:

* Fracture in surgical diagnosis
* Hospital admission \>1 day preoperatively
* End-stage renal disease (preoperative)
* Metastatic disease (preoperative)
* Sepsis (preoperative)
* Bleeding diathesis (preoperative)
* American Society of Anesthesiologists Physical Status Classification 5
Predictive Model Identifies Painful Sedation-free Colonoscopy

Colorectal cancer is one of the most common cancers globally and a leading cause of cancer-related death. Colonoscopy is the standard screening method for colorectal cancer, significantly reducing mortality rates. However, the pain experienced during the procedure is one of the main reasons people avoid getting a colonoscopy. If operators can identify patients who are more likely to feel pain before the procedure, operators can take steps to reduce their discomfort. Previous research has developed a model to predict discomfort during colonoscopy, but this model have some limitations in clinical use. Therefore, investigators plan to develop a new model that also predicts the likelihood of painful colonoscopies.

This study aims to identify factors related to pain in non-sedated colonoscopy and create a more accurate prediction model to help reduce pain during the procedure.

A total of 455 patients will be divided into two groups randomly for training and validation. Participants meet the inclusion criteria for this study, and investigators will ask participants to participate voluntarily. If participants agree, investigators will collect some of participants basic information and medical history, and assess participants' pain during the procedure.

Participants will only need to follow the doctors' instructions, complete bowel investigators' preparation, and undergo the colonoscopy as usual. The data collection will not interfere with participants' regular care


Eligibility Criteria:
Inclusion Criteria:

1. Patients undergoing non-sedated colonoscopy at Ningbo University Affiliated Hospital from September 2024 to September 2025.
2. Age: Patients aged 18 to 75 years.
3. Voluntary participation: Patients who voluntarily agree to participate in the study and have signed the informed consent form.

Exclusion Criteria:

1. Patients under 18 years old.
2. Patients who are unwilling or unable to provide informed consent.
3. Patients with malignant diseases, severe chronic heart or lung diseases, or those who have received treatment or radiation therapy for coronary artery or cerebrovascular events requiring hospitalization in the past 3 months.
4. Patients with a history of colorectal resection or those with an incomplete colon.
5. Patients who do not require reaching the ileocecal valve.
6. Patients who have not completed bowel preparation or who have only used enemas for bowel cleaning.
7. Patients with severe bowel obstruction or bowel perforation.
8. Pregnant or breastfeeding women. -
Neonatal Neurological Examination to Detect Infants at Risk

The study aims to establish the diagnostic vcalue of a structured neurological examination to detect eraly neurological abnormlaities in infants at risk of neurological abnormlaiyies.

The study aims to establish the diagnostic vcalue of a structured neurological examination to detect eraly neurological abnormlaities in infants at risk of neurological abnormlaiyies.

Infants at risk of neurological abnormlaiyies, such as very pèretrm infants and infants with asphyxia or with overt neyurologocal abnormla signs suh as convilsions will be assessed with a structured neurological examination and followed over time.

Eligibility Criteria:
Inclusion Criteria:

all newborns with neonatal encephaolopathy or at risk for neurological abnormlaities, such as preterm infants born below 34 weeks or those with convusions

Exclusion Criteria:

families unwilling to sign consent
New Three-dimensional Methods of Analysis for the Detection of Coronary Artery Disease by Dobutamine Stress Echocardiography

The investigators are going to recruit patients who have a scheduled elective coronary angiography and going to do a dobutamin stress echography (DSE) before the coronary examination. Next to a regular 2D-DSE, the investigators will perform an 3-dimensional DSE, incl ventriculography. In the interventional part (coronary angiography), they will measure each stenosis with fractional flow-reserve (FFR)and herewith graduate its stenosis severity.

Background

Coronary heart disease is the leading cause of death worldwide. Non-invasive, radiation-free diagnostic needs further improvement. In this study, the investigators test the hypothesis that their method, which measures the myocardial deformation using 3D echocardiography is superior to previous ultrasound technologies with regard to diagnosis of stable coronary artery disease. The aim is establish an improved, non-invasive method to diagnose stable coronary artery disease.

Objective

The investigators want to investigate if a 3D-speckle-tracking is superior and more accurate in predicting hemodynamically significant coronary artery stenosis than predicted by 2D echocardiography? The reference variable for the hemodynamic significance of coronary artery stenosis is invasively measured by coronary flow reserve (CFR) in consideration of collateral flow (CFI).

Methods

This is a prospective observational study. The investigators will include 100 persons who are scheduled for an elective coronary angiography.

A regular 2D-stress echocardiography according to the international guidelines will be performed (incl. PLAX, SAX, 2CV, 4CV). The classification of regional wall motion abnormality is carried out according to the internationally recognized standards in 16 myocardial segments of the LV, with a grading of wall thickening (0 = dyskinetic, akinetic = 1, 2 = hypokinetic, 3 = normal). In addition, a 3D speckle tracking is performed after data transfer. To determine the functional relevance of any stenosis (reference method) a flow reserve in a maximum of two coronary arteries will be performed.

Test accuracy of 2D stress echocardiography and the new 3D method for detecting a significant stenosis (CFI \<2) are then compared.

Eligibility Criteria:
Inclusion Criteria:

* Scheduled elective coronary angiography
* Age \>/= 18 years
* Written informed consent

Exclusion Criteria

* Age \< 18 years
* Acute coronary syndrome
* Unstable angina pectoris
* Coronary 3-vessel disease
* Left-main artery affected
* Situation after myocardial infarction
* Coronary anomaly
* Situation after coronary bypass
* Congenital heart disease
* Pacemaker
* Any contraindication concerning stress-echo