cyrilzakka/clinical-trials huggingface dataset:
Quantitative Ultrasound of Trapezius Muscle in Cervical Myofascial Syndrome

The myofascial points within the trapezius muscle are hypoechogenic regions that can be depicted via ultrasound imaging. In this study we aimed to demonstrate the hypoechogenic regions within the trapezius muscle and to determine if physical therapy modalities change the appearance and size of these areas. We also wanted to explore if the presence of these areas correlate with pain.


Eligibility Criteria:
Inclusion Criteria:

* Patients with myofascial pain syndrome in the cervical region

Exclusion Criteria:

* Presence of cervical radiculopathies
* Previous history of cervical injusy
* Presence of rheumatologic diseases
Human Photoallergy Test

To evaluate the potential of a test material to produce a photo allergic response.


Eligibility Criteria:
Inclusion Criteria:

* be male or female between the ages of 18 and 60 inclusive;
* be lightly pigmented (Fitzpatrick Skin Type I, II, III);
* have read and signed the written Informed Consent Form and have completed a Health Insurance Portability and Accountability Act (HIPAA) Authorization Form in conformance with 45CFR Parts 160 and 164;
* be in general good health as determined by the subject's medical history and in the discretion of the investigator;

Exclusion Criteria:

* have a visible sunburn;
* have a history of sun hypersensitivity/photosensitivity or photosensitive dermatoses;
* have a known hypersensitivity or allergy against any of the active and non-active ingredients of the investigational products;
* subjects who are employees of the CRO and/or Bayer or is a household member of an employee;
Efficacy of a Positive Psychological Intervention in Patients With Eating Disorders

This study is aimed to test the efficacy of a positive psychological intervention for promoting positive emotions and optimistic thinking in eating disordered patients. Participants are randomly assigned to receive the positive intervention or the control condition, which consists on thinking about daily activities.

Eating disorders (ED) are very difficult conditions to treat. Therefore, interventions in this field are shifting their main target towards the disorder's impact in quality of life, rather than ED symptomatology in itself. In this sense, a focus in the promotion of positive emotions and well-being is emerging in order to buffer from the harmful effects caused by ED.

Positive psychological interventions have shown efficacy in the promotion of positive emotions and well-being. In this sense, one of these interventions is called Best Possible Self (BPS), since is aimed to enhance positive emotions and well-being. Specifically, BPS is a positive future thinking technique, which requires people to envision themselves in the future, after everything has gone as good as it possibly could. This exercise has shown efficacy improving optimism, future expectancies and positive affect compared to a control condition, in general population and depressive patients.

Furthermore, the progress of Information and Communication Technologies, has allowed the development of technology applications and devices that could enhance the quality of experience and the well-being levels. This approach is called Positive Technology and it can be used as a complement to positive psychological interventions. Positive Technology can be defined as the scientific and applied approach to improve the quality of our personal experience trying to increase wellness and generate strengths.

Taking into account the prior literature, the aim of the present study is to carry out a randomized controlled study with ED patients in order to explore if BPS is able to produce improvements in different well-being and clinical measures. The exercise will be applied through a Positive Technology system. The design employed in this study is similar to the used in other studies.

Five assessment moments were used: Before the exercise (baseline), after the first session (day 1) and post-training (1 month). Moreover, two follow-ups were included: one month after finishing the training period (1st follow-up) and three months after finishing the training (2nd follow-up)

Eligibility Criteria:
Inclusion Criteria:

* Subject has a diagnosis of Eating Disorder by a Clinical Psychologist according to DSM-IV criteria
* Subject accepts to participate in the study voluntarily

Exclusion Criteria:

* Subject suffering a severe physical condition
* Subject suffering from substance or alcohol depedence
Management Strategy of Polypoid Lesions of the Gallbladder

We retrospectively review a single-center cohort of gallbladder polyps from January 2015 to May 2020. Univariate and multivariable analyses were performed to extract potential risky factors of neoplastic polyps. Also, a comparison was conducted between laparoscopic cholecystectomy (LC) and laparoscopic polypectomy (LP) to explore factors affecting surgeons' decision on LC or LP.


Eligibility Criteria:
Inclusion Criteria:

Surgical indications for LC included polyp diameter over 10 millimeters, or polyps accompanied by GB stones, or consideration of neoplastic polyps. Surgical indications for GB-preserving surgery included GB with normal emptying function and polyp diameter smaller than 10 millimeters, or consideration of benign non-neoplastic polyps, or asymptomatic polyps.

Exclusion Criteria:

Those do not fit for laparoscopic surgery.
En Evaluation of Navina Mini, a New Low-volume Transanal Irrigation Device.

This is an un-controlled, prospective, multi center, post market clinical follow-up investigation that will enroll male and female subjects in need of bowel management with low-volume transanal irrigation (TAI) as judged by the investigator. A total of 40 investigational subjects in need of low-volume TAI will be recruited from 2-3 sites in Sweden and will be treated with Navina Mini as per product intended purpose and per instruction of use during a period of four weeks.

Participating subjects will perform three visits during the clinical investigation and will be followed for a total of four weeks. The first visit, Visit 1, will be performed at the investigational clinic to assess eligibility, collect demographics, baseline data and instruct how to use the device. Visit 2 will be performed after two weeks of treatment through telephone contact. The final visit, Visit 3, will be performed after additional two weeks of treatment, and can be performed either at the investigational clinic or through telephone contact.


Eligibility Criteria:
Inclusion Criteria:

* Signed informed consent
* Anal incontinence or faecal outlet problems without any pathological obstruction in the ano-rectum.
* Symptom duration of \> 6 months
* Adult male and females \>18 years old
* Patient can communicate in written and oral Swedish language

Exclusion Criteria:

* Subjects treated with high volume TAI i.e., volume \> 250 ml
* Pregnancy at the time of enrollment
* Participating in another clinical investigation interfering with this investigation
* Subjects with active, symptomatic inflammatory bowel disease, radiation proctitis and or active perianal fistula disease
* Rectal bleeding of uncertain origin or active hemorrhoidal bleeding
* \< 6 months after anal or colorectal surgery
* Ongoing anti-coagulant therapy (eg. NOACS, heparin, Warfarin)
* Acute diverticulitis and diverticular abscess
* Ischemic colitis
* Colorectal cancer
* Any physical handicap that prevents usage of product
* Inability to use product or anyone to assist in its usage
* Person not suitable for the investigation according to the investigator judgement
Effect of Acetazolamide on Postural Control in Lowlanders Older Than 40 Years at Altitude

Randomized, placebo controlled trial evaluating the effect of acetazolamide on postural control in lowlanders older than 40 years travelling from 760 m to 3'100 m.

This is a randomized, placebo-controlled, double-blind parallel trial evaluating the effect of preventive acetazolamide intake on the postural control in lowlanders older than 40 years travelling to altitude. Participants living in the Bishkek area, Kyrgyzstan (760m), will be transferred by car within 4h to the Tuja Ashu high altitude clinic (3'100 m), and stay there for 2 days. Acetazolamide 375mg/day (or placebo), will be administered before departure at 760 m and during the stay at altitude. Outcomes will be assessed during the stay at 3'100 m.

An interim analysis will be carried out when 80 participants will have completed the study or after the first year. The Peto's method will be used and the trial will be stopped when pre-specified futility boundaries were crossed.

Eligibility Criteria:
Inclusion Criteria:

* Healthy men and women, age 40-75 yrs, without any disease and need of medication.
* Born, raised and currently living at low altitude (\<800m).
* Written informed consent.
* Kyrgyz ethnicity

Exclusion Criteria:

* Any active respiratory, cardiovascular or other disease requiring regular treatment or being otherwise relevant for tolerance of hypoxia or altitude exposure.
* Any condition that may interfere with protocol compliance including current heavy smoking (\>20 cigarettes per day or \>20 pack-years with active smoking during the last 10 years), regular use of alcohol.
* Allergy to acetazolamide and other sulfonamides.
Evaluate Efficacy and Safety in Japanese Subjects With Type 2 Diabetes Mellitus

This is a 24-week randomised, multi-centre phase III study to evaluate the efficacy and safety of dapagliflozin as monotherapy in Japanese subjects with Type 2 diabetes mellitus who have inadequate glycemic control with diet and exercise.


Eligibility Criteria:
Inclusion Criteria:

* Provision of informed consent prior to any study specific procedures
* Men or women age ≥20 years old (Either gender needs to be 40% or higher of total number of treated subjects)diagnosed with type 2 DM ; ≥6.5% and ≤10% at 1 week before randomization

Exclusion Criteria:

* Type 1 diabetes mellitus
* FPG \>240 mg/dL before randomization
* Subjects who have history of unstable or rapidly progressing renal disease
* Subjects who have severe hepatic insufficiency and/or significant abnormal liver function
* Significant cardiovascular history
"LiverColor": Machine Learning in Liver Photographs

The main goal of this project is to create a machine learning model in order to quantify liver steatosis in liver donor faster, more objective and reliable than histological analysis and surgeons point-of-view.

Surgeons (junior and senior operators) from the HBP \& Transplantation Unit took the pictures. They were taken after the laparotomy and before any type of surgical procedure. For each deceased donor case, a total of 5 pictures were taken: one for the left lobe and another for the right one before undergoing a surgical biopsy, two more (one for the left and one for the right lobe) after the histological analysis, near to the site of the surgical biopsy, and finally, one picture after liver perfusion.

Eligibility Criteria:
Inclusion Criteria:

* Livers from donor donor brain death with informed consent before inclusion in the study was obtained from all participants or families.

Exclusion Criteria:

* Age \< 18 years old
* Donor after cardiac death
* Split
* Cholestasis due to a biliary obstruction
* Total bilirubin levels above 2,5 mg/dL
* Glutamic oxaloacetic transaminase (SGOT)/ serum glutamatepyruvate transaminase (SGPT) levels and gamma-glutamyl transaminase (GGT) levels above 400 U/L
* Cirrhotic livers
Hypofractionated Radiotherapy for Prostate Cancer

Radiotherapy is a standard definitive treatment for men with localized prostate cancer.

Recent improvements in technology allow high doses of radiation to be delivered to the prostate in less days with lower doses to surrounding healthy tissues, trying to reduce side effects.

This study is being proposed to evaluate the use of moderate hypofractionated volumetric radiotherapy in localized prostate cancer patients and assessing treatment -related later adverse events using the CTCAE 4.0

Recent evidence suggests that the same or better outcomes might be achieved in prostate cancer by ussing a higher dose of radiation per fraction ( 3Gy) with the consequent decrease in total days Quality of life outcomes as well as gastrointestinal and genitourinary late toxicities will be analyzed.

It is thought that this regimen will produce comparable findings and would result in substantial health care cost savings, as well as, be more convenient for patients.

Eligibility Criteria:
Inclusion Criteria:

* Histologic confirmation of adenocarcinoma of the prostate by biopsy
* Performance Status 0-2
* Signed informed consent form

Exclusion Criteria:

* Positive lymph-nodes or metastatic disease from prostate cancer on imaging studies
* Anticoagulant treatment, individual assessment of antiplatelet therapy
* Previous pelvic radiotherapy
* Previous surgery for prostate cancer
* Previous transurethral resection of the prostate
* History of Crohn's Disease or Ulcerative Colitis
* Antecedents of rectal fistulas in the last 10 years
* Previous significant urinary obstructive symptoms
* Previous chemotherapeutic treatments
* Non-compliance with constraints established in this protocol (see special section
Comparison of Muscle Energy Technique vs Static Stretch in Vertical Jump of Basketball and Volleyball Player

A randomized control trial study was conducted in Islamic International University Islamabad from 1st August 2017 to 31st January 2018 according to the set criteria. A total number of 29 athletes age between 18-35 and playing as part time/ domestic level included in this study. Data were divided into experimental group (n=15) and control group (n=14) by random sampling technique. Post isometric relaxation technique was used in experimental group and static stretching was given in control group. Baseline reading was taken before intervention and post intervention reading taken immediately after application of intervention. Data analyzed through SPSS 20.

Vertical jump is defined as the ability of athlete to elevate off the ground from standstill.There are two types of vertical jump which re squat vertical jump and vertical stop jump. There was a strong correlation between maximal strength in half squats and sprint performance and jumping height.

Muscle energy technique(METS) is the procedure which involves voluntary contraction of muscle in specific direction with different angles against a counterforce applied by clincian.METS is used to enhance strength of group of muscle, increase afferent input to facilitate reflexive stabilization and increase endurance in coordinated movement patterns.

Athletes perform dynamic stretching before sports involvement. Study shows that three 30 seconds stretch enhance muscle length immediatley after stretching.

A study conducted in 2003 to see the effects of muscle energy technique on hamstring extensibility, the conclusion of this study that muscle energy technique produced an immediate increase in passive knee extension.

A study conducted on immediate effect of two muscle energy techniques on quadriceps muscle during vertical jump. The study suggests concentric muscle energy technique on quadriceps muscle is the most appropriate technique to potentiate height jump performance and stretch-shorten cycle function in counter-movement jump.

Athletes ususully perfrom stretching exercises in warm up before involvement to sports.Study suggest that dynamic stretching is more suitable for use as part of warmup in young athletes. Athletes invlve in high intensity exercise demand stretch shorten cycle, stretching may be important for injury prevention. Stretching also reduce the peak torque and mean power output.

Eligibility Criteria:
Inclusion Criteria:

* Athletes (volley ball and basketball players) playing at part time/domestic level.
* Athletes age between 18-35 Years.

Exclusion Criteria:

* Athletes having history of sprain or strain in lower limbs within last 6 months.
* Athletes having any neuro-musculoskeletal, cardiovascular pathology
Study of the Association of Nonalcoholic Fatty Liver Disease With Colorectal Malignant Neoplasm

The aim of this sudy is to investigate the prevalence of colorectal cancer (CRC) in patients with nonalcoholic fatty liver disease (NAFLD) and evaluate whether NAFLD is a risk factor for CRC.

As one of the most common cancer worldwide, colorectal cancer (CRC) is a major cause of cancer death in Asian countries. And during the past three decades, the incidence of CRC has been increasing rapidly in china. Many studies supported that cigarette smoking, obesity and insulin resistance were associated with CRC. In recent years, metabolic syndrome (MetS) - Including glucose tolerance, dyslipidemia, obesity, hypertension and chronic inﬂammation - and its individual components have been proven to be the risk for colorectal neoplasm. Colonoscopy is the most accurate technique for diagnosis, surveillance and exclusion of colorectal neoplasm for high-risk CRC groups. Therefore, improved risk stratiﬁcation knowledge of the target population is necessary to improve CRC patients' prognosis.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide and cause a wide spectrum of liver damage, such as steatohepatitis, cirrhosis, even end-stage liver disease and hepatocellular carcinoma. NAFLD has been found to be associated with obesity, insulin resistance, hypertension and dyslipidemia, and is considered as a liver manifestation of MetS. Although it has been also well established that MetS and its individual components are risk factors for colorectal neoplasm, as above, there is paucity of research looking at the relation between NAFLD and CRC. Therefore, the investigators aimed to investigate the prevalence of CRC in patients with NAFLD and evaluate whether NAFLD is an independent risk factor for CRC.

Eligibility Criteria:
Inclusion Criteria:

* Patients had colonoscopy and
* Patients had conventional inspections(blood routine, liver function test and abdomen B ultrasonography)

Exclusion Criteria:

* Patients were excluded with history of colorectal cancers or polyps, other extraintestinal malignancies and contraindications to colonoscopy.
* Patients were excluded who had viral hepatitis, cirrhosis, liver cancer or other liver disease.
* Patients ere excluded who drank more than 20g alcohol per day.
Omega 7 Oil and Inflammatory Biomarker Study

The purpose of the study is to determine whether the palmitoleic acid supplementation can reduce the serum inflammatory biomarkers and low quality of life scores due to musculoskeletal discomfort. The study design is a 2-arm placebo-controlled double blind crossover trial. The randomized sequence of a single crossover is divided into 1:1 and each supplementation is three weeks with no washout in between.

The purpose of the study is to investigate whether or not the supplementation of a particular omega-7 fatty acid decreases the serum biomarkers of inflammation, i.e. highly sensitive C-reactive protein, TNF-alpha and IL-6 of participants who have been experiencing decreased quality of life (QOL) and having elevated these serum markers. The study is placebo-controlled and conducted in a double blinded manner. Participants will be crossed over on supplements (active and placebo) in a random sequence. The total length of a trial is six weeks in which the participants will be asked to maintain stable diet. The baseline blood draw, physical exam, range of motion, QOL and dietary assessment and taking vitals are performed. After the blood test results and/or QOL assessment confirm the eligibility, three weeks supply of the investigational supplement will be mailed or picked up in person. The supplementation is one gel-capusule a day for three weeks. At the end of three weeks, another blood draw, physical exam, range of motion, and QOL assessment are conducted; then the other investigational supplement will be provided. The assessment of the second supplement will occur after another three-week mark. If no adverse reaction is observed and there is no concerns, the participant will be exited from the study.

The goal of enrollment is 50 participants who are between 18 to 99 years old with decreased quality of life and potentially elevated serum markers of inflammation. Volunteers will be randomized by a block of four so at any given moment, one group does not exceed more than three participants. The study takes place at Kenmore campus.

Eligibility Criteria:
Inclusion Criteria: (any of the below)

* baseline CRP 1.0 mg/L or higher
* \> 3 months (chronic) musculoskeletal pain/discomfort, which the participant is able to monitor during the course of trial (6 weeks)

Exclusion Criteria:

* Taking narcotic or opioid pain medication
* Unable to monitor NSAID or OTC pain medication quantity
* Unable to visit Kenmore Washington Clinical Research Center for three times
* Objection from his/her primary care doctor
* Employee or family member of Barlines Organics
Resistant Starch Type-3, Glucose Metabolism and Appetite

Resistant starch (RS) is considered to have many of the same health benefits as dietary fiber. The aim of this study was to examine the effects of RS3 on postprandial glycemic and insulinemic responses and appetite.

Healthy males (aged 18-35 years) participated in this study. Subjects were provided meals in the laboratory after overnight fasting on two separate occasions, at least 1 week apart. On each laboratory visit, subjects were given either a control meal (COM) or an RS3 meal (RSM). Both meals during the two visits consisted of vegetarian pasta and were matched for energy intake, composition, ingredients, and amount, but were prepared in different ways. The COM was hot, freshly cooked pasta, while the RSM was re-heated pasta that had been cooked the previous day and chilled overnight. Blood samples and subjective appetite ratings were collected at fasting and for a period of 3 h after meal consumption (i.e., 15-min intervals for glucose and 30-min intervals for insulin, ghrelin, and subjective appetite).


Eligibility Criteria:
Inclusion Criteria:

* Healthy males
* Aged between 18 and 40 years
* Normal weight (BMI 18.5-24.9 kg/m2)
* No history of serious disease or currently taking any medications
* Not dieting or seeking to lose weight.

Exclusion Criteria:

* Smokers
* Allergy to gluten-containing products, lactose intolerance, or dairy allergy
* Particular dislike to any of the foods provided during the study.