cyrilzakka/clinical-trials huggingface dataset:
Assessment of Functional Ability and Follow-up at Home for Older Medical Patients

The aim of this study is to examine the effect of an intervention that consist of assessment of functional ability, rehabilitation plan and follow-up at home for older medical patients.

The hypothesis is that assessment of functional ability, development of rehabilitation plan and follow-up at home reduce the older medical patient's risk of readmission. Also the intervention is expected to reduce mortality, number of contacts to general practitioners and emergency physician


Eligibility Criteria:
Inclusion Criteria:

* Patients admitted to Medical Visitations Section (MVA) Aarhus University Hospital
* Aged 65+
* Resident in City of Aarhus

Exclusion Criteria:

* Patients admitted from nursing home
* Patients transferred to other hospital departments
* Patients terminally ill
Analyzing the Impact of Occlusal Reduction on the Pain Following Root Canal Therapy in Molar Teeth With and Without Pain in Turkish Patients.

Introduction: This study aimed to compare the intensity of postoperative pain after single-visit root canal treatment of symptomatic or asymptomatic teeth following occlusal reduction.

Methods: A total of 140 symptomatic or asymptomatic patients in need of root canal therapy were registered in this prospective, single-center, single-blind, randomized clinical trial.

For all patients, root canal treatment was carried out in a single visit, and the teeth were restored using composite resin. The teeth were randomly allocated into two equal groups according to whether occlusal reduction was done or not. The patients' pain were assessed using a 0-3 verbal rate scale 1, 3, and 7 days following root canal treatment. The pain incidence and intensity were compared using the chi-square and Fisher's exact tests.

Root canal treatments is usually associated with post-operative pain and this is a bothersome situation for both patient and practitioner. Due to this reason number of researches focus on the factors that may relief patients pain. Occlusal reduction is one of the factors that means the chewing surface of the teeth are cut off and no longer in contact.Despite the large number of studies on this subject, no consensus has been reached. Decoupling group standardization and arriving at a more consistent conclusion were the goals of this research. The aim of this research is to evaluate the impact of occlusal reduction on postoperative pain in both symptomatic and asymptomatic molar teeth.

Eligibility Criteria:
Inclusion Criteria:

* Healty patients
* Maxillary and mandibulary first and second molars
* Irriversible pulpitis cases with or without prior discomfort

Exclusion Criteria:

* Patients under 18 years old,
* Patients older 65 years old,
* Teeth with previously undergone root canal treatment,
* Complicating systemic diseases,
* Allergies o local anesthetic agents,
* Presence of acute apical apsesses,
* History of trauma,
* Analgesic, antibiotic or antiinflamatory intake 7 days before treatment,
* Periodontal pockets deeper than 4 mm,
* Multiple teeth that require endodontic treatment,
* Pregnancy,
* Teeth that can not be restored,
* Patients who needed emergency treatment,
* Grade 2 or 3 mobility,
* Patients with bruxism
Substance Use Risk and Solution-Focused Approach

Although substance abuse is the subject of serious struggles on the basis of individuals and countries, its rate of spread cannot be stopped and it creates an agenda with new people added every day. Substance addiction, which not only creates physiological problems in individuals, but also affects human health in every aspect with psychological and social problems, adversely affects the health status of individuals as well as their families and environments. The best way to get rid of addiction is to never start. Therefore, our study focused on preventing addiction, not addiction. After applying the Substance Use Tendency Scale and Self-Control Scale to university students, an intervention and control group will be formed. Solution Focused Approach program will be applied to the intervention group. At the end of the program, post-tests will be applied to the intervention and control groups.

First of all, the Substance Use Tendency Scale (MDAS) and personal information form will be applied to the nursing students of the Faculty of Health Sciences, which consists of 750 people. A high score in any of the BCAS subscales indicates a tendency towards addiction. After this, students with a tendency will be determined. After the power analysis is performed, the appropriate number of samples will be determined. Finally, participants will be assigned to the intervention/control group by randomization. A substance use prevention psychoeducation program based on a solution-focused approach will be applied to the experimental group in 7 sessions for 6 weeks. No intervention will be made to the control group. At the end of psychoeducation, posttests will be collected from the experimental and control groups.

Eligibility Criteria:
The criteria for inclusion in the research at the stage;

* Being an active student registered as a nursing student at Fırat University
* Volunteering to participate in the research.
* Not receiving any psychological counseling and treatment
* Getting a sufficiently high score in any of the sub-dimensions according to the Substance Use Risk Profile Scale
* Not being diagnosed with substance abuse or substance abuse Exclusion criteria from the study at Phase I;
* Not complying with the principle of volunteering
* Getting a low score in all sub-dimensions according to the Substance Use Risk Profile Scale
* Being diagnosed with substance abuse or substance abuse
Implementation Research on the Intervention Mode of " Comorbidity-Co-causes-Joint-prevention" Comprehensive Demonstration District of Depression and Obesity Among Children and Adolescents in Beijing

Depression and obesity have become the most prominent health problems among adolescents and have caused a heavy burden on the health and social economy of the whole population. There are high incidence, comorbidity and co-pathogenic factors of depression and obesity in adolescents, but there is still a lack of research on joint prevention strategies and multi-sectoral collaborative prevention and control network. This project plans to screen and integrate effective intervention measures based on multi-stage optimization strategy, developing an intervention mode of \[Comorbidity-Co-causes-Joint-prevention\] for adolescents with depression or/and obesity, and then carry out with children or adolescents in Beijing based on digital platform. The investigators will be considering the accessibility, sustainability and replicability of the implement based on the RE-AIM framework including the coverage of population and organizations as well as the effect, implement and sustainability of the interventions. The research will be promoted with the help of the National Clinical Research Center for Mental Disorders and Monitoring of Student Common Diseases and Health Influencing Factors. The results of the research will establish an intervention mode of \[Comorbidity-Co-causes-Joint-prevention\] and a promotion model for adolescents' depression and obesity in Beijing, providing support for the realization of Healthy China 2030 and Healthy Beijing 2030 Plans.


Eligibility Criteria:
Inclusion Criteria:

* Stage I (screening stage):

  1. Middle school students in Beijing Economic-Technological Development Area and other districts of Beijing, both male and female;
  2. Students themselves and their guardians are willing to participate in this study and sign written informed consent file.

     Stage Ⅱ:

     Middle school students who were identified as high risk of depression and/or obesity in Stage I in Beijing Economic-Technological Development Area and other districts of Beijing, the screening criteria are as follows:

     ① CES-DC score ≥16 points;

     ② BMI ≥WS/T586-2018: Screened as overweight and obesity among school-age children and adolescents, according to the recommendation by the National Health Commission;

     ③ Students themselves and their guardians are willing to participate in this study and provide written informed consent.

     Exclusion Criteria:
* Stage I:

  1. Having serious physical or genetic disease that is not suitable for participation in the study;
  2. Have been evaluated that not suitable for this study by investigators.

Stage Ⅱ:

1. Having serious physical or genetic disease that is not suitable for participation in the study;
2. Have been evaluated that not suitable for this study by investigators.
Protocols and Guidelines for the Use of Digital Twins in Frail Older People

The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders from a biomechanical standpoint.

It is typical for the elderly to present with weakness, slowed movements and reduced levels of physical activity, all of which may be related to the loss of muscle force (dynapenia). Unfortunately, to date, the primary cause for dynapenia is difficult to identify. Digital twins may help to this end, but their development remains critical as it requires a specialized skillset and experimental data for model personalisation.

In this study, where the investigators will recruit a small group of frail elders and a cohort of healthy young individuals, all participants will undergo the following examinations: (i) gait assessment, (ii) maximal voluntary isometric contraction (MVIC) test, (iii) superimposed neuromuscular electrical stimulation, and (iv) full lower limb magnetic resonance imaging. Surface electromyography data will further be collected while the subjects perform both the gait assessment and the MVIC test. Last, clinical questionnaires will be administered, and the subjects will be asked to perform additional clinical measures (i.e., hand-grip test, bioelectrical impedance analysis).

At the end of the study, a reduced version of the experimental protocol will be developed, with the intent to provide clinicians with a protocol that can be deployed in clinical settings, accounting for the observed reliability and repeatability of each measure, the required level of expertise, and the associated costs and time expenditure.


Eligibility Criteria:
Inclusion Criteria:

* Age: 65-80 years
* Body Mass Index between 18.5 and 30 kg/m2
* Frailty syndrome diagnosed according to Fried's criteria (i.e., at least three of the following items: unintended loss of weight, weakness, self-reported exhaustion, slow walking speed, low level of physical activity)

Exclusion Criteria:

* Any musculoskeletal, neurological, rheumatic or tumoral diseases
* Dementia
* Diabetes
* Inguinal or abdominal hernia
* Severe Hypertension (Level 3)
* Severe Cardio-pulmonary insufficiency
* Diagnosis of Osteonecrosis in the lower limb joints
* Pathologies or physical conditions incompatible with the use of magnetic resonance imaging and electrostimulation (i.e., active and passive implanted biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)
* Previous interventions or traumas to the joints of the lower limb

NOTE: A group of healthy volunteers, who meet the following criteria, will be enrolled in the study:

Inclusion Criteria:

* Age: 20-40 years;
* Body Mass Index: 15-30 kg/m²;
* Physical activity level (Saltin-Grimby): 2-4
* No previous or known musculoskeletal, neurological, rheumatic or tumoral diseases
Validation of a Mobile App as an Adjuvant Treatment

Health tourism is one of the most important touristic activities. It can generate economic and social value. Balneotherapy is one of the options concerning healthcare and well-being. Although this fact it lacks information concerning effectiveness of thermal water treatments. Digital Technologies are being implemented and developed in health care systems, stimulated also by World Health Organization (WHO), in order to facilitate and improve patients' treatment and assessment. Traditional approach does not allow a follow-up due to the fact the patient leaves the thermal complex after treatment or several other reasons due to that the gap persists and social security of each country avoids support based on this lack of information. It is important to fulfil this gap and for that digital technologies seem to be the answer.

This study aims to investigate effectiveness in self-management and clinical assessment and monitorization between a smartphone app (HealthSmArt_ISAVE) and a standard approach.

This will be a single-blinded, parallel two-arm group randomised, controlled, superiority trial with a 12 months of intervention period in real thermal treatment conditions, in Caldelas, Amares, Portugal. The target population will be recruited among the patients who use the thermal environment in Caldelas- Amares.

The random sequence, with a 1:1 allocation of participants in control and intervention groups is going to be generated using an external website. The outcome data will be collected from stored data by a research assistant who is blinded to the treatment arm.

The study will be supported by clinicians, physiotherapists, and psychologists and will be developed in ISAVE in partnership with Complexo Termal de Caldelas.

The guideline SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) will be used for report elaboration and the manuscript will follow CONSORT (Consolidated Standards for Reporting Trials) guidelines for the transparent reporting of randomized trials.

Eligibility Criteria:
Inclusion Criteria:

* Adults, in treatment at Complexo Termal de Caldelas- Amares, Portugal,
* with chronic musculoskeletal problems
* respiratory issues
* with satisfactory cognitive analysis for exercise

Exclusion Criteria:

* having received intramuscular or intraarticular steroid injections within 4 weeks, pregnancy, moderate or severe cognitive impairment
Nutritional Supplementation in Children Aged 1-3 Years Experiencing Growth Concerns

This open-label clinical trial will gain evidence of the effect of an oral Nutritional Supplement (NS) to help improve catch-up growth and support learning skills in children with growth concerns.


Eligibility Criteria:
INCLUSION CRITERIA

1. Evidence of a personally signed and dated informed consent document indicating that the child's parent(s) / legally acceptable representative (LAR) has been informed of all pertinent aspects of the study.
2. Child was full-term at birth (i.e., ≥ 37 completed weeks of gestation with a birth weight of ≥ 2.5 kg and ≤ 4.5 kg).
3. Child is age 12 - 36 months and generally healthy (acute illness in a minor condition which are common in childhood such as viral or bacterial infection e.g. conjunctivitis, otitis media, upper/lower respiratory tract infection, gastroenteritis, hand foot \& mouth disease at time of enrolment is permitted).
4. Children whose parents show some concern about their child's growth, such as child is too thin for his or her length/height, child has experienced recent rapid weight loss or failure to gain weight or length/height, or child's growth curve shows a downward trajectory of growth velocity
5. Child has a weight-for-length/height ≤ 25th percentile as per WHO growth charts.
6. Parents agree to feed their child a nutritional supplement in addition to normal diet.
7. Child's parent(s) / guardian can be contacted directly by telephone or email throughout the study.
8. Child's parent is of legal age of consent, must understand the informed consent form and other study documents, and is willing and able to fulfill the requirements of the study protocol.

EXCLUSION CRITERIA

1. Child is currently breastfed or is consuming breast milk
2. Child has known or suspected cows' milk protein intolerance / allergy, lactose intolerance, soy intolerance / allergy, fish oil intolerance / allergy, or other food allergies that impact diet.
3. Child fed vegan, vegetarian, or vegetarian plus fish diets in which milk products are excluded
4. Child has chronic illness or other disease including any condition that impacts feeding or growth
5. Child having any congenital malformation (e.g., gastrointestinal tract atresia) or surgery sequelae (e.g., short bowel syndrome) potentially affecting feeding or growth
6. Child has been diagnosed with Infantile anorexia nervosa
7. Child has other medical or psychiatric condition that, in the judgement of the investigator, would make the child inappropriate for entry into the study.
8. Child or child's parent(s) not willing and/or not able to comply with scheduled visits and the requirements of the study protocol.
9. Child of any investigational site staff member or Nestlé employee directly involved in the conduct of the trial.
10. Child is currently participating in or has participated in another clinical trial within 4 weeks prior to enrolment.
Treatment of Chronic Hepatitis C With PEG Interferon alfa2a and Ribavirin in HIV-Infected Patients

Combination of PEG interferon and ribavirin is the standard treatment of chronic hepatitis C. Efficacy of this treatment has never been evaluated in HCV-HIV infected patients, who have previously been treated with a first line anti-HCV treatment. The purpose of the study is to evaluate the combination PEG interferon alfa2a-ribavirin in HIV-infected patients with chronic hepatitis C pretreated with interferon alone or interferon combined with ribavirin. The patients receive a dose of 180 µg of PEGASYS once a week and 800 to 1200 mg/day of ribavirin (according to weight) for 48 weeks. Primary outcome of the study is a sustained virological response, defined as an undetectable HCV RNA level 24 weeks after the end of anti-HCV treatment.


Eligibility Criteria:
Inclusion Criteria:

* Chronic hepatitis C : Detectable HCV RNA, Previously treated with interferon or interferon combined with ribavirin, Elevated ALT level
* HIV infection (CD4\>250/µL, HIV RNA\<10 000 copies/ml) treated or not with antiretroviral therapy
* Signed informed consent

Exclusion Criteria:

* Chronic hepatitis B
* Alcohol consumption\>40g/day
* Evidence of decompensated liver disease
* Hepatocellular carcinoma
* Other relevant disorders: organ transplantation, psychiatric or cardiovascular disease, poorly controlled diabetes, seizure disorders, hemoglobinopathy, autoimmune disease
Comprehensive Home-based Dementia Care Coordination for Medicare-Medicaid Dual Eligibles in Maryland

This Center for Medicare and Medicaid funded health care innovation award will implement the MIND at Home dementia care coordination program (called MIND at Home-Plus) through two community-based service agencies (Jewish Community Services, Johns Hopkins Home Care Group) to rapidly improve the ability of 600 dually eligible older adults with dementia in the Baltimore region to remain at home while improving care quality, enhancing quality of life, and reducing total health care costs. MIND at Home participants receive an in-home needs assessment followed by up to 18 months of care coordination aimed at filling unmet needs.

The demonstration project has 3 major tasks which will be implemented in concurrent, iterative phases: (1) implement MIND-Plus in 2 community-based health service agencies to rapidly improve the ability of 600 community-living dually eligible older adults with AD in the Baltimore region to remain at home while improving care quality, enhancing quality of life, and reducing total health care costs associated with institutional care or hospitalization; (2) develop a replicable model for nationwide diffusion of the MIND program through a web-based certification package designed to prepare for implementation, build work-force capacity through training certification modules, and provide automated self-monitoring and quality improvement tools; and (3) develop and test a detailed payment model that takes a blended approach and includes provider care management fees with provider performance incentives from division of shared savings.

The investigators hypothesize that the MIND-Plus dementia care coordination program will (1) rapidly improve health \& care quality and reduce total health care costs among Medicare-Medicaid dually eligible community-living older adults with AD, (2) drive health care system transformation by creating a new CMS financed benefit that would shift the hub of dementia care coordination to well-trained, dementia competent, interdisciplinary teams based in community health agencies, (3) achieve a sustainable payment model that produces significant net savings and incentives provider performance. This "shovel ready" community-based model is expected to improve outcomes within 6 months and save an estimated net-saving of $12.5 million by over 3 years.

Eligibility Criteria:
Inclusion Criteria:

* diagnosis of dementia
* community living
* has identified study partner willing to participate
* english speaking

Exclusion Criteria:

* situation at time of referral is a medical or mental health crisis
* they plan to move out to another area or into a residential care facility in the next 6 months
* they are currently on hospice.
Understanding Patient Perspectives on the Risks of Ionizing Radiation Used for Medical Imaging

Risks from imaging-related radiation exposure have become a popular topic in the media. Because these tests are commonly applied to patients at a cancer center, it is important to understand what patients know, how they feel about what they know, where they get their information, and how satisfied they are with available risk-benefit communication on this topic.

The purpose of this study is to understand how cancer patients perceive risks and benefits of diagnostic radiation and their satisfaction with healthcare communication on this topic.


Eligibility Criteria:
Inclusion Criteria:

* English-language fluent
* 18 years of age, or older
* Provide informed consent
* Group 1: Patients undergoing chemotherapy for Stage IV colorectal carcinoma.
* Group 2: Parents of pediatric patients who have undergone treatment for stage 1-3 neuroblastoma.
* Group 3: Women who have undergone treatment for early stage breast cancer within the preceding 6 months.
* Group 4: Men undergoing surveillance imaging after treatment for testicular cancer.
* Group 5: Patients currently or previously enrolled in the MSKCC lung cancer screening program.
* Group 6: Patients enrolled in or eligible for the thoracic survivorship program.

Exclusion Criteria:

* Participants who don't speak English