cyrilzakka/clinical-trials huggingface dataset:
Interest of Branched Chain Amino Acids Associated With a Respiratory Rehabilitation Program in Patients Broncho Chronic Obstructive Pulmonary Disease

Respiratory rehabilitation is one of the main treatments for COPD in the early stages of the disease (Stage 2 of GOLD) with a recognized effect on improving the capacity of the patients to exert effort by fighting against deconditioning. the effort. This treatment also improves the quality of life of patients and reduces the risk of respiratory exacerbations. The patients are very often malnourished and various studies have proposed the addition of oral supplementation such as hormone therapy (testosterone) to improve the exercise performance of these atrophied muscles. The use of branched-chain amino acids (AARs) such as valine, leucine, isoleucine in this indication can be fully justified because they stimulate protein synthesis and promote muscle maintenance and repair.


Eligibility Criteria:
Inclusion Criteria:

* Patients Broncho Chronic Obstructive Pulmonary Disease in stages 2 and 3 of the GOLD classification, whose Maximum Expiratory Volume on the first second is between 30% and 80% of the expected theoretical value, associated with a maximal expiratory volume ratio on the first Second / Vital Capacity less than or equal to 70% of the expected theoretical value.
* Patients of both sexes, aged 40 to 80 years
* In case of active smoking, patients must commit to interrupting it during the respiratory rehabilitation program that will be proposed to them in this study

Exclusion Criteria:

* - Age \<40 years or\> 80 years
* Patients with a contraindication to exercise,
* Phenylketonuria
* Patients treated with long-term oxygen therapy and / or home ventilation will not be included.
* Patients with acute respiratory decompensation in the three months prior to inclusion.
* Patients with known allergy to milk, gluten, soy, egg and nuts
* Patients taking part in another clinical trial or who have participated in a clinical trial in the 3 months preceding this study.
Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients

The purpose of this study is to see if it is safe to combine methadone with two HIV protease inhibitors (PIs), ritonavir (RTV) and saquinavir (SQV), in HIV-infected patients not currently taking PIs. This study will measure the interactions between methadone and the PIs.

Methadone is used treat addicts and to treat severe pain. In order to find the safest way to use methadone with PIs, it is important to evaluate how they interact.

Methadone is extensively used in the maintenance treatment of addicts and in the management of severe pain. In order to use methadone with HIV protease inhibitors correctly, it is important to evaluate and quantify interactions between the protease inhibitors and methadone.

Patients receive their usual daily dose of methadone followed with ritonavir and saquinavir, respectively, twice a day. Patients are evaluated on Day 4 for safety and tolerance, and their ritonavir dose is increased. On Day 8 patients are evaluated for a steady-state level of methadone. After 2 weeks of the protease inhibitor therapy, they return for methadone pharmacokinetic sampling at Day 15 over 24 hours. Both protease inhibitors and methadone are administered on Day 15 on an inpatient basis. On Day 30, patients are assessed for safety and tolerance.

Eligibility Criteria:
Inclusion Criteria

You may be eligible for this study if you:

* Are HIV-positive and have an HIV RNA count below 100,000 copies/ml within 30 days prior to study entry.
* Are taking methadone.
* Are at least 18 years old.
* Are within 40% of your ideal body weight and weigh at least 99 lbs.

Exclusion Criteria

You will not be eligible for this study if you:

* Are allergic to or are unable to take RTV or SQV.
* Have a history of treatment failure with indinavir, RTV, or SQV.
* Have a history of certain illnesses that might prevent you from completing the study.
* Have severe diarrhea or other stomach problems.
* Have taken any PI within 4 weeks prior to study entry.
* Would be unable to complete the study due to alcohol or drug abuse.
* Are co-enrolled in other protocols that have you taking medications that are prohibited in this study.
* Are taking PIs other than RTV or SQV.
* Are receiving certain therapies or are taking certain medications, including experimental drugs.
* Have an active opportunistic (AIDS-related) infection or disease that requires medication within 14 days prior to study entry.
* Are pregnant or breast-feeding.
COVID-Impact "Psychological IMPACT of Covid-19 on AP-HP Staff"

The epidemic of coronavirus induces a major influx of patients implying a rapid modification of the organizations, a work overload and a significant stress for the care teams and supports of the hospitals of the Assistance Publique - Hôpitaux de Paris (AP-HP) . To this is added the impact on each professional of the large number of very severe patients to be treated, of death and the anxiety of contamination, reinforced by the actual cases of staff themselves sick. Emergency phone numbers for professionals in the event of psychological suffering were quickly put in place at the AP-HP and Hospitals level. The objective of this study is to assess the psychopathological and psycho-traumatic consequences of this exceptional situation on the staff, during the epidemic and at a distance from it, in order to be able to target the solutions to be implemented. Hypothesis is that some personnel may develop one or more of the following disorders: adjustment disorder or other anxiety disorder, acute stress disorder, post-traumatic stress disorder (PTSD), and depressive episodes as defined in the DSM-5. This study also aimes to assess effect of support measures put in place, by comparing the evolution of those who benefited from those who did not use them, as well as the risk factors specific. The results will make it possible to have an estimate of the percentage of people who may require specific support, and to identify the staff most at risk, and thus predict the importance of the circuits and structures for support of staff which will be necessary in the short and long term. The main anticipated risk factors are: being a nurse, having a low number of years of professional experience, and being on the front line of care for affected patients.


Eligibility Criteria:
Inclusion Criteria:

* AP-HP professionals on duty during the COVID epidemic agreeing to participate in the three stages of the study.

Exclusion Criteria:

* none
Relationship Between the Biological and Psychological Correlates of PTSD

This study will determine the effectiveness of immediate treatment with prolonged exposure therapy (PE) versus delaying treatment with PE in altering neuroendocrine-related symptoms of post-traumatic stress disorder in women.

Post-Traumatic Stress Disorder (PTSD) is a psychiatric disorder that can occur following exposure to a traumatic incident in which grave physical harm occurred or was threatened. PTSD is marked by clear biological changes as well as psychological symptoms. Many people with PTSD repeatedly relive the trauma in the form of flashback episodes, memories, nightmares, or frightening thoughts. Chronic PTSD can also affect the neuroendocrine system by altering functionality of some chemicals in the brain, including cortisol and catecholamines (e.g., norepinephrine). This study will determine the effectiveness of immediate treatment with prolonged exposure therapy (PE) versus delaying treatment with PE in altering neuroendocrine-related symptoms of post-traumatic stress disorder in women.

This single-blind study will randomly assign two thirds of participants to PE therapy immediately following a traumatic event and one third to a waitlist condition (WL), in which they will receive no treatment until a later date. Participants assigned to receive PE will do so once weekly for 10 weeks. Participants assigned to the WL condition will receive no treatment for 10 weeks, and then will begin PE therapy once weekly for an additional 10 weeks. Study visits will occur at baseline, Week 10, and 6 months post-treatment for those in both conditions, with additional visits 10 weeks and 6 months post-PE therapy for those in the WL condition. Psychological measurements to be assessed at these visits will include PTSD symptoms, anxiety, depression, and PTSD-related cognitions. Physical assessments will include urine and saliva tests, as well as a dexamethasone-suppression test. Participants in the PE condition will also provide saliva samples at points throughout the study to monitor changes in cortisol and catecholamines.

Eligibility Criteria:
Inclusion Criteria:

* Chronic post-traumatic stress disorder
* Minimum of 3 months passed since traumatic event happened
* Agree to use an effective form of contraception throughout the study

Exclusion Criteria:

* History of schizophrenia, bipolar disorder, or cognitive dysfunction due to a general medical condition
* History of alcohol or other drug abuse or dependence within 3 months of study enrollment
* Mental retardation or other pervasive developmental disorder
* Unwillingness or inability to discontinue current psychotherapy treatment (stable psychiatric medication therapy taken during the study is not criteria for exclusion)
* Significant risk of violence or history of serious violent behavior within one year of study enrollment
* Medically unstable condition
* Continuing intimate relationship with the perpetrator when the trauma involves assault
* At risk for suicide risk
* Currently pregnant
Medications After Adolescent Bariatric Surgery

This study will assess the feasibility to assess practicality of early weight loss medication usage in adolescent patients post-VSG with inadequate weight loss. Participants who enroll in the study will be prescribed off-label use of weight loss medications for a period of up to 1 year.


Eligibility Criteria:
Inclusion Criteria:

* Surgical patients in the LPCH/Stanford bariatric and weight management clinics
* Inadequate weight loss after vertical sleeve gastrectomy

Exclusion Criteria:

* Adequate weight loss after surgery;
* Unwilling to consent or adhere to safety monitoring plan;
* Any life-threatening or terminal diseases
* Currently pregnant, breastfeeding, or thinking of becoming pregnant
* Allergy or medical contraindication to phentermine or topiramate;
* History of drug or alcohol abuse;
* No known medication interactions;
* Significant renal or hepatic impairment;
* Participation in a study of an investigational medication 30 days prior to screening, while the patient is on study, and for 30 days after their last dose of study treatment
Fibrin Glue for Perianal Fistulas in Crohn's Disease: a Randomized Controlled Trial

This multicenter, randomized, controlled trial was conducted by the Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif (GETAID) to evaluate the efficacy and safety of the injection of fibrin glue in perianal fistulas tracts of patients with CD. The institutional Independent Ethics Committee of Marseille, France and of Liège, Belgium approved the protocol for each participating centers. Recruitment took place at 12 sites (11 in France and 1 in Belgium)


Eligibility Criteria:
Inclusion Criteria:

* at least 18 years old
* CD confirmed by endoscopy and histology.
* CDAI should be 250 or less
* at least one perianal fistula (between anus or low rectum and perineum, vulva or vagina) draining for more than 2 months duration

Exclusion Criteria:

* treatment with an anti-TNF agent or with ciclosporin or tacrolimus within the last 3 months
* presence of a perianal abscess (\>1cm) assessed by magnetic resonance imaging (MRI) or endo-anal ultrasonography performed within the last month,
* presence of anal or rectal stenosis,
* surgery during the previous month (except seton removal),
* previous fibrin glue injection,
* pregnancy.
Physiotherapy and Rehabilitation Students' Incontinence Knowledge Level

The aim of the study is to examine the urinary incontinence knowledge level and attitudes towards treatment in Physiotherapy and Rehabilitation students. With this study, students' knowledge levels about urinary incontinence and treatment parameters will be determined, and it will be possible to show whether there is a difference between genders in terms of knowledge levels.

The aim of the study is to examine the urinary incontinence knowledge level and attitudes towards treatment in Physiotherapy and Rehabilitation students. With this study, students' knowledge levels about urinary incontinence and treatment parameters will be determined, and it will be possible to show whether there is a difference between genders in terms of knowledge levels.

At least 260 students studying in the Physiotherapy and Rehabilitation Department in Turkey will be included in the study.

Eligibility Criteria:
Inclusion Criteria:

* Being a student of Physiotherapy and Rehabilitation department in Turkey
* Being volunteer

Exclusion Criteria:

- Failing to complete surveys
Evaluation of Apexogenesis With Human Treated Dentin Matrix in Young Permanent Molars

Assess the clinical, radiographic, and tomographic outcomes of apexogenesis with human treated dentin matrix in young permanent molars compared to MTA.

The study was conducted as a split-mouth randomized clinical trial, approved by research ethics committee, Faculty of Dentistry, Tanta University, and carried out at Pediatric Dentistry Department, Faculty of Dentistry, Tanta University. The material preparation was conducted at Pharmaceutical Technology Department, Faculty of Pharmacy, Tanta University. 20 children of both sexes aged from 6 to 8 years old were selected with bilateral deeply carious young permanent mandibular first molars that are indicated for vital pulp therapy.The selected deeply carious molars were randomly divided into two groups as follows:

Group I (Study group): 20 molars were treated with human TDM. Group II: (Control group): 20 molars were treated with White MTA. The participating cases were evaluated clinically and radiographically after 6, 12 and 18 months. Tomographic evaluation was performed immediate postoperatively and at 18 months.

Eligibility Criteria:
Inclusion Criteria:

1. Bilateral immature permanent mandibular first molars with deep carious lesions.
2. Positive response to pulp testing.
3. Normal radiographic appearance.
4. Healthy children without any systemic disease that interferes with pulp healing.
5. Patient and parent cooperation.

Exclusion Criteria:

1. Clinical signs and symptoms of irreversible pulpitis as spontaneous throbbing pain, tenderness to percussion, abnormal tooth mobility, swelling, or sinus tract.
2. Presence of periapical lesion, external or internal root resorption.
3. Carious furcation involvement.
4. Dystrophic calcification of the pulp.
5. Non restorable tooth.
The Effects of Acupuncture for Major Trauma

Major trauma is a significant cause for morbidity and mortality in the world. After traumatic injury, the damage tissue could induce systemic inflammatory response (SIRS) and activate autonomic nervous system in response to stress, followed by compensatory anti-inflammatory response (CARS). Imbalance of SIRS and CARS may lead to organ failures, sepsis and death.

The investigators design a prospective clinical trial to investigate the efficacy of acupuncture for major trauma.

Eligibility Criteria:
Inclusion Criteria:

* Male or female aged 20 years or older
* Confirmed diagnosis of major trauma with ISS ≥ 16

Exclusion Criteria:

* Pregnancy
* Malignancy
* Pacemaker
* Status epilepticus
* Severe medical disease
* Life threatening
* Prior history of drug or alcohol dependence
* Immunodeficiency
* Vagotomy
Care for Post-Concussive Symptoms

The proposed study is a pilot randomized trial of a stepped collaborative care intervention designed to decrease post-concussive symptoms and improve post-injury functioning among sports-injured youth aged 11-17. Participants with persistent post-concussive symptoms (symptoms persisting at least two months post-injury) will be recruited from Seattle Children's Hospital departments of sports medicine and rehabilitation medicine. Consent and assent will be obtained in-person. Participants will be randomized to receive either the stepped collaborative care intervention, or treatment-as-usual. Participants will be assessed on a range of symptoms and areas of functioning at four time points: 0 months, 1 month, 3 months, and 6 months after enrollment. The primary hypothesis is that the intervention group athletes, when compared to usual care control group athletes, will demonstrate clinically and statistically significant reductions in postconcussive, anxiety, and depressive symptoms over the course of the 6-month study. Secondary analyses will assess the impact of the intervention on functional impairment including missed school days and other academic outcomes. Exploratory analyses will examine MRI findings that are characteristic of postconcussive neuropathology, if available in medical record, as predictors of treatment responses.


Eligibility Criteria:
Inclusion Criteria:

* Between ages 11 and 18
* Have sustained a head impact during sports participation
* Have incurred an onset or increase of at least three post-concussive symptoms following head impact
* Have increased post-concussive symptoms following head impact have continued for at least 4 weeks
* Live with their parents or legal guardians
* Live within commuting distance of Seattle Children's Hospital
* Willing to participate in assessment and treatment
* Have at least one parent/caregiver willing to participate in assessment and treatment

Exclusion Criteria:

* Meet Diagnostic and Statistical Manual of Mental Disorders (DSM - V) criteria for a psychotic disorder or bipolar disorder
* Active suicidality
* Substance dependence
The Influence of Oral Hygiene on Local Wound and Systemic Infection in Patients With Percutaneous Endoscopic Gastrostomy Placement

Percutaneous endoscopic gastrostomy (PEG) is commonly used for long term enteral feeding of patients with severe dysphagia. The most common complication is peristomal wound infection. The possible mechanism the bacterial from the oral cavity disseminate during the PEG insertion through the stomach to the abdominal wall, in spite the routine use of antibiotic prophylaxis, have reported low rates of wound infection in patients who were already receiving antibiotics at the time of PEG Our hypothesis that washing the oral cavity with antibiotic solution prior the insertion PEG , We planned a prospective, randomised, double blind, one centre study of antibiotic mouth wash solution (0.2% Chlorhexidine gluconate) as.prophylaxis in PEG


Eligibility Criteria:
Inclusion Criteria:

* All patients scheduled to undergo PEG

Exclusion Criteria:

* Previous GI surgery
* Coagulopathy
* Sepsis
PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles and Health Care

The purpose of the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care is to use clinical data from electronic health records (EHR) and patient reported outcomes (PRO) to answer questions of clinical importance to patients, providers, and other stakeholders.

The primary objective is to create the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care, which will allow the conduct of patient-centered observational studies on weight across the multiple institutions of the PaTH network. Creating the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care will involve:

1. Recruiting patients with longitudinal weight data in the EHR to participate in the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care
2. Administering surveys to the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care approximately every 6 months to collect patient reported outcomes (PROs)
3. Collecting individual patient health record data into the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care database
4. Identifying potential participants for future research studies.
5. Tracking whether the patient participant has biospecimens in a PaTH site biorepository and prepare for possible sharing of biospecimens in future studies.

The secondary objectives are to use the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care to answer patient-centered research questions including:

(1) How do survey response rates, sample demographics and survey responses differ by recruitment technique? (2) What are patients' weight management strategies? How much are health care providers contributing to their weight management approaches? Do these relationships vary by weight status, region, age, sex, or race; (3) What are patients' reasons for seeking bariatric surgery and expectations in terms of weight change?; (4) Among patients seeking bariatric surgery, what proportion with high risk for sleep apnea by survey responses have been evaluated for or diagnosed with this health problem? (5) How does physical activity vary with patients co-morbidity status?

Eligibility Criteria:
Inclusion Criteria:

* Age in years (\>= 18 years), at the time of the initial data query
* Height - at least 1 at any time; can be outside 5-year cohort time window
* Weight : Two encounters each with weight within the 5-year cohort time window

Exclusion Criteria:

* Deceased
* Not proficient in English
* Already enrolled in the PaTH Clinical Data Research Network (CDRN) Study of Healthy Lifestyles, Body Weight and Health Care in another PaTH institution