cyrilzakka/clinical-trials huggingface dataset:
Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease

The common causes of mortality are late stages of chronic kidney disease, cardiovascular disease and infections, are associated with abnormalities of the immune system, an underlying state of chronic inflammation and oxidative stress. These processes have not been carefully described in the chronic kidney disease population. The researcher can use Diffuse Optical Spectroscopy to determine the immune system in individuals with chronic kidney disease and describe the association with chronic inflammation and oxidative stress in that population.

The Diffuse Optical Spectroscopy can measure the absolute concentrations of reduced and oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin concentration, water and lipid concentrations of the tissue.

The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study. The researchers can use Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to clinical parameters such as cause of chronic kidney disease, blood pressure and dialysis-related parameters.

Eligibility Criteria:
Inclusion Criteria:

* 18 years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
* 18 years and older for control

Exclusion Criteria:

* acute kidney disease
A New Designed Balance Platform for Children

People always come across with different floors which gradually affect dynamic balance. Dynamic balance is important in activities of daily life of all people. There are various reliable and valid tests for both children and adults, but no test design which includes different floor materials has been developed. Thus, this study aimed to describe a new designed balance test platform and investigate its reliability and validity in 3-5 years old children.

Children whose families signed consent form will be included. Height and weight will be measured. Then they will be taken to the balance measurements. Design will firstly be shown to child and one trial will be permitted before starting the test. Timed-up and Go test will also be used as a reliable and valid test for dynamic balance in this age group. Single leg standing will also be used to investigate the discrimination feature of the dynamic balance tested by new design platform.

All tests will be done without socks and shoes. Timing will be the only results for all tests. Calibrated chronometers will be used for this aim. After all measurements complete, statistical analysis will be conducted.

Eligibility Criteria:
Inclusion Criteria:

* Chid aged 3-5 years (birth date: December 2013 - December 2015)
* Parents who signed consent form.

Exclusion Criteria:

* Children who have problem about musculoskeletal system, neurological disorder, vestibular system disorders.
* Children who mention painful situations which may possibly prevent to walk on the platform
* Children who have visual problems
Validity and Reliability of Autocad Software Assessment of JPS in PFPS

The overall aim of the study is to assess the reliability and validity of Autocad software to measure JPS in PFPS, especially:

1. To assess the intra-tester and between day reliability of measurement of JPS using Autocad software.
2. To assess the validity of these measurements against those found during an IKD.

Patellofemoral pain syndrome (PFPS) is a common painful musculoskeletal condition that affects physically active young adults and adolescents.

Joint position sense (JPS) is considered as a component of proprioception as it provides the clinician with information regarding the accuracy of movement as well as its relationship with movement performance and injuries. Therefore researchers use advanced instruments as 3 D video systems and isokinetic dynamometer. Since these instruments are less portable and expensive, therefore researchers used another method to evaluate JPS using high precision software using video analysis and markers in the joints. Unfortunately, video analysis requires difficult and time-consuming tasks and that this slow the evaluation process.

Although immediate feedback could help physiotherapists and athletic trainers to monitor athletes and make decisions during the training session and the rehabilitation process, such immediacy is not available for proprioceptive tests in field situations. Autocad software is available and inexpensive and provides immediate feedback

Eligibility Criteria:
inclusion criteria:

1. Anterior or retropatellar knee pain from at least 2 of the following Activities : (1) prolonged sitting; (2) stair climbing; (3) squatting; (4) running; (5) kneeling; (6) hopping/jumping; (7) kneel sitting
2. Insidious onset of symptoms unrelated to a traumatic incident.
3. Age of the subject 18-35 years to limit the possibility that PFPS over age 35 may have been complicated by arthritic changes, and also the subjects should have closed epiphyseal growth plates.
4. Patient with chronic PFPS (pain \> 3 months)

Exclusion Criteria:

1. Meniscal or other intraarticular pathologic conditions; cruciate or collateral ligament involvement.
2. A history of traumatic patellar subluxation or dislocation.
3. Previous surgery in the knee, ankle and hip joints.
4. Knee, ankle and hip joints osteoarthritis.
5. athletes weren't included.

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Efficacy of Therapeutic Exercise (Mirror Image Exercise) in Adolescent With Chronic Low Back Pain, Through Corrective of Postural Changes; Randomized Controlled Trial

This study will include two groups. The study group will receive mirror-image postural exercise on the 3D postural analysis. The control group will receive a traditional exercise program.


Eligibility Criteria:
Inclusion Criteria:

* Having chronic mechanical low back pain.
* Having a significant translational and/or rotational deformity of the lumbar spine according to the posture index scale.
* Having normal x-ray

Exclusion Criteria:

* Severe cardiovascular disease.
* Previous spinal surgery.
* Abdominal hernia.
* True leg length discrepancy.
* Severe respiratory disease.
* Pregnancy.
* Associated pathologies of lower limbs that may interfere with the posture such as foot, knee, and hip deformities.
Singapore Cardiac Longitudinal Outcomes Database

The research project aims to perform data extraction, integration and analysis across multiple clinical, administrative, financial and pharmacy databases in the participating institutions. The key data components will include clinical cardiovascular specific data, procedural data, financial and administrative data (e.g. cost of medications and supplies, length of stay, diagnosis codes etc.), short-to-long term clinical outcomes (including hospital re-admissions, cardiovascular events, death), and quality-of-care indices (e.g. compliance to guideline-recommended therapy and medications). The research project will involve all patients proven and/or suspected with coronary artery disease (CAD), congestive heart failure (CHF) and atrial fibrillation (AF) admitted to National Heart Centre Singapore (NHCS) and NUH.

The research project is initiated by NHCS and its participating institutions include Ministry of Health (MOH), as well as National University Hospital (Singapore) Pte Ltd (NUH), Changi General Hospital (CGH), Khoo Teck Puat Hospital (KTPH), Singapore General Hospital (SGH), Tan Tock Seng Hospital (TTSH), Ng Teng Fong General Hospital (NTFGH) , SingHealth Polyclinics, National Healthcare Group Polyclinics (NHGP), Sengkang Hospital (SKH), National University Polyclinics (NUP), and Alexandra Hospital (AH).

The research project will leverage on the Health Data Grid (HDG) pilot project, now known as Business Research Analytics Insights Network (BRAIN). BRAIN will be a virtual repository that will enable access to anonymised and merged data from disparate databases at multiple institutions. The structures of BRAIN will preserve patients' privacy and confidentiality, ensure IT security and allow access only by authorised persons. The BRAIN pilot project will be co-funded by MOH and the Infocommunication Media Development Authority of Singapore (IMDA). To avoid doubt, after the BRAIN pilot project, a separate approval from the appropriate stakeholders will have to be sought for further funding of the operating costs of the BRAIN, regardless of whether the value of the BRAIN has been demonstrated during the BRAIN pilot project. There is no direct cost involved in the research project.

For the research project, MOH will contribute administrative data from the Registry of Births and Deaths, Casemix \& Subvention, the Mediclaim, and Omnibus databases, and the other participating institutions will contribute the data from the National Electronic Health Records (NEHR), Electronic Health Intelligence System (eHIntS) and Enterprise Data Warehouse (EDW) to BRAIN. Only anonymised data from BRAIN will be utilised for the research project.

Eligibility Criteria:
Inclusion Criteria:

* all patients who present to a healthcare institution with either CAD or suspected CAD (including chest pain); CHF or suspected CHF; AF or suspected AF

Exclusion Criteria:

* non-Singaporeans
UHR-OCT and HD-OCT for Preretinal Membranes: ICG Versus Membrane Blue

Using the UHR-OCT and HD-OCT to evaluate early postoperative changes in patients with diagnosis preretinal membrane after successfully performed pars-plana vitrectomy and membrane peeling with two different types of dyes.

Surgical procedures performed are pars-plana vitrectomy and membrane peeling with or without cataract extraction and IOL implantation. The type of the dyes is randomized. The study is designed to include a total of tweny cases (10 cases with ICG and 10 cases with Membrane blue)

Main outcome measures are:

UHR-OCT, HD-OCT distance and near visual acuity and contrast sensitivity amsler grid secondary outcome measures are: OCT Stratus 3000 and visual field. Clinical examinations: preoperative, and follow-up examinations after 1 week, 1 months, 3 months, 6 months and 12 months.

Eligibility Criteria:
Inclusion Criteria:

* Preretinal membrane
* Age between 18 and 85 years
* Combined surgery possible(phacoemulsification and vitreoretinal procedure)

Exclusion Criteria:

* Age-related macular degeneration
* Previous retinal detachment surgery
* Previous laser treatment
Safety and Efficacy of Adjustable Gastric Band Operations for Patients With Body Mass Index (BMI) Between 30-40 kg/m2

This study is to evaluate the safety and efficacy of Gastric Banding for patients with body mass index (BMI) between 30-40 kg/m2 with medical conditions related to obesity.

TITLE OF STUDY:A prospective study to evaluate the safety and efficacy of LAP-BAND® Adjustable Gastric Band (LAGB®) operations for patients with BMI between 30-40 kg/m2 with co-morbidities

CLINICAL PHASE: Phase III new indication for use of the device not yet approved by FDA

STUDY OBJECTIVES

* To determine the safety and efficacy of the LAP-BAND® Adjustable Gastric Band (LAGB®) for patients with BMI between 30-40 kg/m2 with co-morbidities
* To determine long-term effects on patients' co-morbidities

STUDY VARIABLES: Morbidity \& mortality, percent of excess weight loss, nutritional status, improvement of pre-operative co-morbidities, weight loss maintained, and quality of life evaluation

DESIGN: Prospective single center study

Eligibility Criteria:
Inclusion Criteria:

* Be at least 18 and equal to or less than 60 years of age.
* BMI of at least 30 and maximum BMI of 40 with co-morbidities
* Willingness to comply with dietary restrictions required by the protocol
* History of obesity for at least 5 years
* History of at least 6 months of documented failures with traditional non-surgical weight loss methods
* Willingness to follow protocol requirements
* If female with childbearing potential, using an appropriate form of contraception

Exclusion Criteria:

* Age less than 18, age greater than 60
* Pregnancy
* History of major depressive disorder or psychosis
* Previous bariatric surgery or previous gastric surgery
* Presence of achalasia
* Presence of portal hypertension, cirrhosis, and/or varices
* Patient with inflammatory disease of the gastrointestinal tract such as Crohn's Disease
* Patients with autoimmune connective tissue disorders
* Patients with acute abdominal infections
* Any condition that, in the judgment of the investigator, would place a subject at undue risk, or potentially compromise the results or interpretation of the study
Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

The purpose of this study is to evaluate the effectiveness of a smoking cessation outreach intervention (TeaM OUT) on increasing use of smoking cessation resources in Veterans. The hypotheses are 1) patients included in the TeaM OUT group will have higher accession of cessation services, such as counseling and medication therapies, compared to patients in enhanced usual care and 2) more patients in the TeaM OUT group will have quit smoking at one year after the intervention.

Veterans with a recently diagnosed lung nodule who currently smoke will receive the TeaM OUT intervention or Enhanced Usual Care. The TeaM OUT intervention has 2 parts: 1) a letter that a) describes the nodule and the importance of cessation related to the pulmonary nodule (i.e. teachable moment) and b) notification that a Proactive IVR Quit Line will initiate contact and 2) call(s) from the Proactive IVR Quit Line which a) offers smoking cessation resources and b) helps connect the patient to those resources. The enhanced usual care group will receive a letter that provides information about how to contact the IVR Quit Line.

The IVR system will track referrals to cessation services. Additional information about smoking status and use of cessation resources will be collected from the electronic health record and surveys.

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Eligibility Criteria:
Inclusion Criteria:

* Newly diagnosed pulmonary nodule with plan for surveillance
* Active smoker
* Receiving care at the Portland VA Health Care System, the Minneapolis VA Health Care System, or the Ralph H. Johnson Medical Center (Charleston, SC VA)

Exclusion Criteria:

-No exclusion criteria
Determinants of Rescue Ventilation Requirement in Airway Surgery Under General Anesthesia With THRIVE

The anesthesia and surgical procedures from the time the patient enters the operating room to discharge from the recovery room are identical to those used in conventional airway surgeries performed under general anesthesia with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE). The time point at which rescue ventilation is required due to a drop in oxygen saturation below 92% during anesthesia will be recorded, and the predictive factors for this event will be investigated.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients undergoing elective airway surgery under general anesthesia with Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE)
* Patients who provide written informed consent

Exclusion Criteria:

* Patients who decline to participate in the study
A Learning Algorithm for MDI Individuals With Type 1 Diabetes to Adjust Recommendations for High Fat Meals and Exercise Management

McGill artificial pancreas lab has developed a learning algorithm using a reinforcement learning approach to adjust basal and bolus recommendations for high-fat meals and exercise management for individuals with type 1 diabetes on multiple daily injections (MDI) therapy. The reinforcement learning algorithm is integrated with a mobile application that gathers insulin, meal information (carbs (if applicable) and high-fat content), mealtime glucose value, glucose trend at mealtime, and type and timing of postprandial exercise.

The objective of this study is to assess the feasibility of a reinforcement learning algorithm to adjust basal and bolus recommendations for high-fat meals and postprandial exercise management. The investigators hypothesize that the reinforcement learning algorithm will be safe, and participants will get the benefit of improved glucose outcomes and improved patient satisfaction from the start to the end of study.

Participants (aged ≥18) will undergo multiple daily injections (MDI) therapy for 4 months using a freestyle Libre glucose sensor (Abbott Diabetes Care) and a mobile data collection application integrated with the reinforcement learning algorithm.

Eligibility Criteria:
Inclusion Criteria:

1. Signed and dated informed consent form
2. Females and males ≥ 18 years old
3. Diagnosis of type 1 diabetes of ≥ 12 months based on the clinical investigator's judgement
4. Undergoing MDI therapy
5. A self-reported diet that consists of at least 3 high-fat meals per week or participation in exercise for at least 30 minutes, two times per week

Exclusion Criteria:

1. Current use of any non-insulin antihyperglycemic medication (SGLT2 inhibitors, GLP 1 receptor agonists, metformin...)
2. Current use of glucocorticoid medication, except inhaled and/or at low stable doses
3. Pregnancy
4. Use of isophane insulin (NPH) or intermediate-acting insulin
5. Significant clinical nephropathy, neuropathy, retinopathy as per the clinical investigator's judgement
6. Acute macrovascular event (ex: acute coronary syndrome or cardiac surgery) within 6 months of admission
7. Severe diabetes ketoacidosis and/or hypoglycemia within one month of admission
8. Other severe medical illness that the clinical investigator considers may interfere with participation in or completion of the study
9. An inability or unwillingness to comply with study procedures as per the clinical investigator's judgement
Maxillary Vascular Canal Thickness and Sinus Augmentation Bleeding

This study aims to evaluate the relationship between the maxillary intra-osseous vascular canal thickness as measured by volumetric tomography and the amount of intra-operative bleeding during open sinus floor augmentation. A sample of patients will be selected, and their maxillary intra-osseous vascular canal thickness will be measured using volumetric tomography. Intraoperative bleeding will be recorded during open sinus floor augmentation. The data will be analyzed to determine if there is a correlation between the thickness of the maxillary intra-osseous vascular canal and intraoperative bleeding.


Eligibility Criteria:
Inclusion Criteria:

* Maxillary partial or total edentulism, including premolar/molar regions
* Medically healthy
* 2 to 5 mm residual bone height
* Sufficient bone width to place a standard dental implant (diameter \>4mm)
* Age: 18-65 years
* Patients who volunteered to participate in the study and signed written informed consent

Exclusion Criteria:

* Maxillary sinusitis
* Acute myocardial infarction in the last 12 months
* Use of any medication that may inhibit bone healing
* History of radiotherapy in the head and neck region
* Presence of psychiatric problems
* Smoking more than 10 cigarettes a day
* Alcoholism
* Chronic drug use
Effectiveness and Safety Study of the Next-Generation DexCom™ SEVEN® Continuous Glucose Monitoring System

The purpose of this study is to evaluate the safety and effectiveness of the next-generation DexCom SEVEN Continuous Glucose Monitoring System (SEVEN.2 System) when worn for up to 7-days by subjects \>18 years-old with diabetes mellitus requiring insulin therapy.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 years or older
* Have been diagnosed with insulin-requiring diabetes and are on multiple daily injections (MDI) or Continuous Subcutaneous Insulin Infusion (CSII) insulin therapy
* Willing not to inject insulin or wear an insulin pump insertion set within 3 inches from the Sensor site during Sensor wear
* Willing to use only the blood glucose meter(s) provided to them for self-monitoring of blood glucose (SMBG) during Sensor wear
* Willing to participate in one, 8-hour in-clinic session and be willing to take 4 fingersticks per hour and have 4 blood draws per hour for the entire 8-hour duration
* Willing to take a minimum of 6 fingersticks per day during home use (2 for calibration purposes, 4 for comparative purposes)
* Willing to refrain from the use of acetaminophen during the Sensor insertion period and for at least 24-hours prior to Sensor insertion
* Willing not to schedule a magnetic resonance (MRI) scan, computed tomography (CT) scan, or x-ray, for the duration of the study
* Able to speak, read, and write English

Exclusion Criteria:

* Have extensive skin changes/diseases that preclude wearing the Sensor on normal skin (e.g. extensive psoriasis, recent burns or severe sunburn, extensive eczema, extensive scarring, extensive tattoos, dermatitis herpetiformis) at the proposed wear sites
* Subjects who have a known allergy to medical-grade adhesives
* Are pregnant as demonstrated by a positive pregnancy test within 72 hours of insertion
* Have a hematocrit that is less than 30%, or greater than 55%
* Current participation in another investigational study protocol (if a subject has recently completed participation in another drug study, the subject must have completed that study at least 30 days prior to being enrolled in this study)
* Have any condition that, in the opinion of the Investigator, would interfere with their participation in the trial or pose an excessive risk to study staff handling venous blood samples (e.g., known history of hepatitis B or C)
Prospective Registration of Severe Pneumocystis Jiroveci Pneumonia Requiring ICU Admission

the investigators aim to set up a multicenter registry study for severe PJP requiring ICU admission. The purpose of this study is

1. to establish a prospective severe PJP registry about clinical characteristics, laboratory and radiographic findings, critical care management and outcomes.
2. to explore the predictive factors associated with outcomes ;
3. to compare the difference between PJP patients with HIV and without HIV infection.

Pneumocystis jiroveci pneumonia (PJP) is a common opportunistic infection in immunocompromised patients. Although the mortality of patients with mild to moderate PJP has declined substantially, the reported outcomes of severe PJP requiring ICU admission, especially with mechanical ventilation are grave. The data on this group of patients is very limited and mainly comes from retrospective studies.

the investigators aim to set up a multicenter registry study for patient with severe PJP requiring ICU admission to provide comprehensive descriptive data on diagnosis, clinical course, critical care management and outcomes in a large cohort.

All patients with PJP admitted to the participating ICU during a two-year period will be enrolled. The CRF will be made available to the participating sites as a printable paper-based CRF.

The following individual patient data for study participants will be collected:

* General demographic information
* Presence of risk factors for PJP and comorbid condition
* use of prophylactic SMZ/TMP, immunosuppressive medications prior to ICU admission
* Information about PJP and co-infection diagnosis
* vital signs, laboratory(blood serum and BALF sample) and radiologic data at ICU admission and during ICU stay
* organ failures and severity of the disease at admission, new onset of organ failures during ICU stay
* Medications for PJP, time course and modalities and settings for respiratory support
* ICU, 28-day mortality, hospital, 90-day mortality

Eligibility Criteria:
Inclusion Criteria:

* diagnosis with PJP, confirmed by PCR or methenamine silver stain of sample from BALF, aspirate or sputum;
* ICU admission due to PJP-related respiratory failure

Exclusion Criteria:

* NO