cyrilzakka/clinical-trials huggingface dataset:
Cryoablation of Intercostal Nerves for Better Control of Postoperative Pain After Thoracic and Thoracoabdominal Open Surgery

The purpose of the registry is to evaluate the peri-operative and short- term outcomes of intercostal nerves cryoablation for post-operative pain control after open thoracic and thoracoabdominal aortic aneurysms repair.

The cryoablation procedure is one of the opportunities for pain control after thoracotomy. So, it is routinely performed in major several centers in aortic surgery around the world as a part of the TAA and TAAA procedure.

The Registry will include approximately 200 patients treated from January 2022 to January 2024 for thoracic or thoracoabdominal aortic aneurysm by means of open surgery and in whom intraoperative intercostal nerves cryoablation will be performed; to reach 200 patients, the enrolments can be extended until January 2027.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients ≥18 years
* Patients who will undergo TAA and TAAA open repair with intraoperative intercostal nerves cryoablation
* Subject has consented for study participation and signed the approved Informed Consent

Exclusion Criteria:

* Patients with active systemic or cutaneous infection or inflammation
* Patients who are pregnant or breastfeeding
* Patients younger than 18 years of age
* Unwilling or unable to comply with the follow-up schedule
* Inability or refusal to give informed consent
* Frank rupture
* Previous stroke with neurological sequelae
Infection Rate of Vertical Expandable Prosthetic Titanium Rib Implants (VEPTR)

The study is conducted to analyse the infection rate in children treated with VEPTR-Implants for severe spine or thoracic deformities.

Spinal and thoracic deformities in children can be treated with vertical expandable prosthetic titanium ribs (VEPTR©, Synthes GmbH®) to stimulate thoracic and spinal growth. With these implants children's symptoms and conditions can be slowed, halted or even reversed. Because of the dynamic character of the deformity and the growth of the children, the implants have to be lengthened about every half a year. With each operation there is a small risk of infection, which might increase with number of previous surgeries. Implant associated infections are often not clinical apparent and only found in microbiological analysis. To objectify the infection rate, identify potential precursors of infections and the relevance of asymptomatic infections in children with these implants a prospective study is conducted.

Eligibility Criteria:
Inclusion Criteria:

* all patients admitted at the University Children's Hospital Basel in whom a VEPTR©-implant or parts of it will be removed.

Exclusion Criteria:

* obvious contamination of an explanted component occurred in the operating room.
Non-invasive Haemodynamic Monitoring to Predict Spinal Hypotension During Caesarian Section

Spinal anaesthesia for elective caesarean section is associated with maternal hypotension, secondary to alteration of sympathetic tone and hypovolemia, in up to 70% of cases.

Our objective, in this prospective single-centre observational study, was to assess the ability of change in systolic ejection volume after 45° passive leg raising to predict hypotension after spinal anaesthesia. Systolic ejection volum was monitored with non-invasive Clearsight Device just before elective caesarean section in third trimester pregnant women.


Eligibility Criteria:
Inclusion Criteria:

* third trimester pregnant women undergoing elective ceasarean section under spinal anesthesia

Exclusion Criteria:

* emergent ceasarean section
* eclampsia or pre-eclampsia
* undergoing anti-hypertensive treatment
* arythmia
The Effectiveness of Kinesio® Tex Tape on Gluteus Medius Activation in Dancers

The purpose of this research is to determine if a specific type of elasticated athletic tape (Kinesio Tex Tape) increases muscle activation among professional level dancers. Investigators will determine if changes in muscle activation with the elasticated tape differ from changes experienced with no tape and/or sham tape, and if it coincides with subjective sense of muscle activation.


Eligibility Criteria:
Inclusion Criteria:

* Uninjured professional level dancers

Exclusion Criteria:

* Non-professional level of dance or non-dancer; obesity (body mass index greater than 30 kg/m²)
* A history of major back, abdominal, or lower extremity surgery
* A history of muscle diseases; a history of serious cardiovascular diseases (e.g., cardiac insufficiency, arrhythmia, severe hypertension, vascular insufficiency)
* A history of serious respiratory diseases; major fractures of the lower extremities; lower extremity or trunk injury within the last year; a history of surgery within the last year, a history of stroke, acute, or chronic infections; serious metabolic diseases
* Glaucoma
* Structural disease or severe congenital deformities of the spine of a high degree
* Inguinal, femoral, or umbilical hernia; or diseases related to body equilibrium.
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene

Development of glucocorticoid (GC)-induced adrenal insufficiency is a serious adverse effect of GC treatment. It is today not possible to predict this adverse effect. The project aims at investigating a possible individual aspect, which may render subjects more or less sensitive to glucocorticoids, and thereby influence development of GC induced adrenal insufficiency. The hypothesis is that subjects with one or another of the polymorphisms in the GC receptor gene will either have increased or diminished GC sensitivity. This may be responsible for differences in development of GC induced adrenal insufficiency.

Blood is sampled from patients with rheumatoid arthritis (RA), fulfilling the inclusion criteria and patients are genotyped for the SNPs N363S, BclI, ER22/23EK and 9β and grouped according to haplotypes. SNPs will be determined by polymerase chain reaction (PCR). Patients will be included for a Synacthen test, to evaluate their adrenal function. Information from the results of the study will be able to assist clinicians to identify patients at risk and thus individualize GC therapy in a tailored fashion. Results of the study will be important for all patient groups worldwide on GC therapy.

Eligibility Criteria:
Inclusion Criteria:

* Adult patients \> 18 years)
* Caucasian classified with rheumatoid arthritis.
* 1987 ACR-classification criteria.
* Prednisolone min 5mg/day for at least 6 months.
* Presence of either BclI (high GC sensitivity) or 9β (low GC sensitivity)polymorphisms, or wildtype for for all 4 SNPs studied. Patients with or without these polymorphisms were invited to a Synacthen® test, but patients with a mixed hetero- and homozygote genotype were not

Exclusion Criteria:

* Other major organ disease
* Females pregnant
* Females not willing to pause estrogen-containing medications 6 weeks prior to Synacthen® test
* unable to give a written informed content
Yoga for Patients With Irritable Bowel Syndrome

The proposed study aims to investigate the feasibility, effectiveness, and perceived benefit of a hatha yoga intervention for patients with irritable bowel syndrome (IBS) compared to nutrition counselling. Further, the potential of both interventions to influence the gut microbiome will be inquired.


Eligibility Criteria:
Inclusion Criteria:

* Patients with irritable bowel syndrome (IBS) diagnosed by physician and confirmed by Rome III diagnostic criteria

Exclusion Criteria:

* inflammatory bowel diseases (IBD)
* total abdominal colectomy
* no sonographie or colonoscopy as diagnostic criterion
* stool lactoferrin \> 7mg/g
* pregnancy or breast feeding
* simultaneous participation in further clinical intervention trials
* Regular yoga practice or nutrition counselling in the past 12 months
* Planned surgery in the study period
* Serious illness that would interfere with the ability to practice yoga
Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer. Gastroesophageal reflux disease, postoperative quality of life, short term outcomes, and long term outcomes will be compared.


Eligibility Criteria:
Inclusion Criteria:

1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
2. Eastern Cooperative Oncology Group performance status of 0 or 1.
3. Adequate organ function.

Exclusion Criteria:

1. Patients had distant metastasis.
2. oesophageal invasion of more than 3 cm.
3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
4. Previous chemotherapy or radiation therapy for any other malignancies.
Shoulder Muscle Imbalance as a Risk Factor for Shoulder Injury in Elite Badminton Players

Background: To assess the impact of pre-season clinical measures and rotator muscles strength on the risk of significant shoulder injury (SSI) in elite badminton players Design: Prospective cohort study Participants: Nineteen elite adolescents badminton players were included and followed over the badminton season (from september 2018 to may 2019 and/or from september 2019 to may 2020) .

Independent variables: A pre-season visit consisted in clinical and isokinetic shoulder strength testing. Clinical testing consisted in the shoulder range of motion (ROM) measurements and the table-to-acromion distance (TAD)Isokinetic internal and external rotator shoulder muscles strength was tested at 60 and 240°/s. Conventional and functional (eccentric-to-concentric) ratios (FR) were calculated. SSI collection was performed by an experienced sport physician.


Eligibility Criteria:
Inclusion Criteria:

All the elite badminton players from a high-level club and the National Institute of Sport, Expertise, and Performance

Exclusion Criteria:

Players who had SSI in the 3 months prior to the isokinetic test or had shoulder surgery
Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD

Non diabetic patients on renal replacement therapy are prone to changes in body composition with an increase in visceral fat and muscle wasting all favoured by the insulin resistant state. Malnutrition is associated with a worst prognosis in these patients. Glitazones are the most powerful insulin sensitisers available in clinical practice which also have anti-inflammatory properties. Their use has been associated with significant and favourable changes in body fat distribution in type 2 diabetic subjects. Experimental studies suggest that glitazones may attenuate muscle wasting in renal failure.

The goal of this study was to examine in non diabetic ESRD patients the effects of pioglitazone on inulin sensitivity and protein metabolism as determined by the hyperinsulinemic euglycemic clamp and on changes in body composition as determined by anthropometric measurements, dual energy X-ray absorptiometry (DEXA) and CT-scan determined changes in abdominal visceral and sub-cutaneous fat.


Eligibility Criteria:
Inclusion Criteria:

Non diabetic individuals with ESRD, on hemodialysis or peritoneal dialysis for at least 3 months. Consent form signed -

Exclusion Criteria:

No infectious complication 3 months prior to entry in the study.

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Treatment Frequency and Satisfaction in Patients With Advanced Prostate Cancer

Patients with advanced prostate cancer usually receive some kind of pharmaceutical castration or undergo surgical castration. At the investigators department the pharmaceutical treatment is most often given with a 3 month interval.

Over the last few years new drugs, which allow for lees frequent treatment, have been developed. The purpose of this study is to assess how the treatment affects patients and if our current patients would prefer to receive treatment at different intervals than they do at the present time. At the same time the investigators will assess how surgical treatment affects our patients. This will be assessed by patient questionnaires administered at our clinic.


Eligibility Criteria:
Inclusion Criteria:

* A diagnosis of advanced prostate cancer
* Receiving hormone manipulation treatment (pharmaceutical castration) OR having undergone surgical castration (orchiectomy)

Exclusion Criteria:

* Inability to read/write Danish
Phase IB Study of Gemcitabine, Docetaxel and Bevacizumab in Patients With Soft Tissue Sarcoma

1.1 To determine the recommended phase II dose for gemcitabine in combination with a fixed dose of docetaxel and bevacizumab.

1.2 To determine the efficacy of the combination of gemcitabine, docetaxel, and bevacizumab in patients with soft tissue sarcoma 1.3 To determine the toxicity profile of the combination of gemcitabine, docetaxel, and bevacizumab in patients with soft tissue sarcoma

Because the combination of gemcitabine and docetaxel has shown impressive activity in soft tissue sarcoma, we hypothesize that the addition of an antiangiogenesis agent (bevacizumab) would enhance the anticancer activity, as shown in other tumor types.

Eligibility Criteria:
Inclusion criteria:

* All patients, 18 years of age or older, with chemotherapy naive soft tissue sarcoma are eligible if there is measurable disease Prior surgery or radiotherapy for the primary tumor is allowed but needs to have been completed at least 2 weeks from entry, and patient should have completely recovered from the procedures.
* Patients must have a life expectancy of at least 12 weeks.
* Patients must have a Zubrod performance status of 0-2.
* Patients must sign an informed consent.
* Patients should have adequate bone marrow function defined by an absolute peripheral granulocyte count of \> 1,500 or cells/mm3 and platelet count \>100,000/mm3 and absence of a regular red blood cell transfusion requirement.
* Patients should have adequate hepatic function with a total bilirubin \< 2 mg/dl and serum glutamate oxaloacetate transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) \< two times the upper limit of normal, and adequate renal function as defined by a serum creatinine \< 1.5 x upper limit of normal.

Exclusion Criteria:

* Patients with symptomatic brain metastases are excluded from this study.
* Pregnant women or nursing mothers are not eligible for this trial. Patients of child bearing potential must use adequate contraception.
* Patients may receive no other concurrent chemotherapy or radiation therapy during this trial.
* Patients with severe medical problems such as uncontrolled diabetes mellitus or cardiovascular disease or active infections are not eligible for this trial.
Pulse Control Using USG and Manual Palpation Methods in Cardiopulmonary Resuscitation

The final approach adopted in Advanced Cardiac Life Support (ACLS) guidelines as defined by the American Heart Association (AHA) and the European Resuscitation Council (ERC) is to minimize the time between chest compressions in cardiopulmonary resuscitation (CPR). Pulse and rhythm checks are recommended between chest compressions and it is stated that this period should not exceed 10 seconds.

All guidelines also state that in cases of low cardiac output or low blood pressure, even if electrocardiographic (ECG) rhythms can be obtained, pulse checks may still fail and an arterial pulse may not be felt during chest compressions. This difficulty in sensing the arterial pulse causes delays in the decision of cardiac arrest in the patient. For this reason, there are cases of cardiac arrest in which the initiation of CPR is delayed or not started at all.

The most common method for checking the pulse is manual palpation. However, since it is an operator-dependent method, it is affected by the experience of the healthcare personnel, the vital values of the patient, and anatomical differences. Therefore, more objective criteria are required to detect a pulse. A clinical study of the reliability of pulse checks showed that most healthcare professionals are unable to detect the presence or absence of a pulse. Another study showed that pulse alone is not sufficient to initiate CPR, and 50% of decisions to initiate CPR based on heart rate are incorrect. Therefore, more objective criteria have been sought to detect the presence of a pulse. For this purpose, evaluations were made regarding the presence of end-tidal carbon dioxide, cardiac echo, and organized rhythm.


Eligibility Criteria:
Inclusion Criteria:

* All adult patients (over 18 years of age) with in-hospital or out-of-hospital cardiac arrest

Exclusion Criteria:

* Patients with traumatic arrest
* Conditions affecting carotid pulse palpation and/or USG application (patients with a history of carotid stenosis or dissection, patients undergoing neck surgery, patients with neck abscess hematoma)
* Pregnant arrest patients
PROCLAIM Registry to Evaluate the Treatment Patterns and Clinical Response in Malignancy

The purpose of this registry is to collect information on patients who are receiving treatment with Proleukin in an organized way, and to learn more about patient care during and after treatment.

The PROCLAIM Registry is a US-based, multicenter Registry designed to establish a high quality observational database of real-world clinical data on HD IL-2 when used to treat patients with mRCC, mM or other malignancies. The Registry will not, in any way, suggest changes in the treatment or management of the patients enrolled in the Registry. Therefore, physicians will continue to manage and treat patients according to standard of care and their own judgment.

The PROCLAIM Registry will start with a retrospective pilot data collection from a de-identified finite number of patient cases abstracted from their existing medical charts. The features collected will be identical to those planned for the prospective registry. The resulting database will be used to formulate hypotheses to be tested using the prospective registry database. Patients utilized in the retrospective analysis will be excluded from the prospective portion of the Registry.

In the prospective portion of the Registry, sites will enroll patients who are expected to start a course of HD IL-2 therapy. Once enrolled, the patient must receive at least one dose of HD IL-2 to remain in the Registry. Patients will be treated and followed according to the site's standard of care. This Registry will in no way induce changes in the management of individual patients. Clinical data features will be entered into an Electronic Data Capture (EDC) system, and organized into a registry database.

The data contained in the registry database will be observational data. The PROCLAIM Registry does not stipulate patient care, specific visits or interventions but merely surveys standardized parameters regarding HD IL-2 and associated therapies as they are applied by treatment centers. The collection of standard data over time permits the evaluation of trends in patient survival and subsequent therapy exposure. The database will be used to answer future queries formulated by researchers.

Eligibility Criteria:
Inclusion Criteria:

* 18 years or older
* Must have received at least one course of high dose IL-2 or Proleukin
* Signed informed consent form

Exclusion Criteria:

* Prior high dose IL-2 or Proleukin therapy
Efficacy, Safety and Underlying Mechanisms of Sphenopalatine Ganglion Acupuncture for Perennial Allergic Rhinitis

In recent years, a number of randomized controlled trials have confirmed the efficacy and safety of acupuncture in the treatment of allergic rhinitis (AR). Indeed, the latest American clinical guidelines recommended acupuncture treatment for AR patients who are interested in non-pharmacological treatment.

In conventional acupuncture treatment for AR, needles are inserted at specific acupoints in the body; with several studies demonstrating acupuncture of sphenopalatine ganglion (SPG) to improve nasal symptoms and quality of life in nasal inflammatory diseases.

The investigators hypothesize that, compared with sham acupuncture and rescue medication (RM), active SPG acupuncture combined with RM would lead to greater improvements in symptoms score and reduction in overall need for antihistamines. To test this hypothesis the investigators design a randomized, double blind, controlled trial to evaluate the efficacy of SPG acupuncture in perennial AR patients (allergic to indoor allergens, including house dust mite, fungi, animal dander and so one) and to explore the potential underlying mechanisms.


Eligibility Criteria:
Inclusion Criteria:

* 1. history of physician-diagnosed PAR with at least 2 years of typical symptoms
* 2. course on each onset lasting at least 4 weeks
* 3. skin prick test and/or serum antigen specific IgE positive to indoor allergens(sIgE≥0.7kU/L,≥class 2)
* 4. good patient compliance on acupuncture treatment
* 5. total nasal symptom scores(TNSS)\>6 at V0

Exclusion Criteria:

* 1. oral steroids within 4 weeks prior to recruitment
* 2. nasal steroids and/or antihistamine 2 weeks prior to recruitment
* 3. seasonal AR
* 4. any respiratory infection within the previous 4 weeks prior to recruitment
* 5. history of nasal polyps, nasal septum deviation, asthma or autoimmune disorders
* 6. previously received acupuncture therapy for AR within 1 month prior to recruitment
* 7. women during pregnancy or lactation
Effect of Genetic Polymorphisms on Platinum Based Chemotherapy in Non Small Cell Lung Cancer

This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients


Eligibility Criteria:
Inclusion Criteria:

1. Newly diagnosed with immunohistochemically and pathologically confirmed non-small cell lung cancer (NSCLC).
2. Eastern Cooperative Oncology Group performance status (ECOG PS) = 0-2.
3. Chemotherapy naïve.
4. Age \>18 years.
5. Adequate bone marrow reserve

Exclusion Criteria:

1. Presence of Central nervous system(CNS) metastases.
2. Inadequate liver function
3. Inadequate renal function
4. Serious comorbid systemic disorder incompatible with the study.
5. Pregnancy
Measuring the Influence of Maxillary Obturator Prosthesis on Facial Morphology in Patient With Unilateral Maxillary Defects Using Stereophotogrammetry

Functional rehabilitation and quality of life after maxillofacial surgery have been emphasized in recent years. It depends mainly on outcomes of maxillofacial reconstruction and rehabilitation involving functions, esthetics, psychology acceptance and resocialization.

Tooth loss, alveolar and maxillary bone resorption or changes of the hard palate cause facial asymmetry in patient with maxillofacial surgery. The facial soft tissue over the defect become recessed as a result of loss of lip and buccal support which lead to decrease the quality of life and psychological disorders. Prosthetic intervention with maxillary obturator prosthesis is necessary to restore the contours of the resected palate and to recreate the functional separation of the oral cavity and sinus and nasal cavities. The purpose of this study is to investigate the influence of maxillary obturator on facial morphology in patient with unilateral maxillary defect by using 3 dimensional digital stereophotogrammetry compared to the intact side of the same patient


Eligibility Criteria:
Inclusion Criteria:

* adult patient of both sexes, 6 months after partial maxillectomy with good periodontal condition of remaining tooth especially abutment tooth.

Exclusion Criteria:

* patient with history of radiotherapy, bad oral hygiene patient with tumor recurrence, patient with mental instability, patient with systemic disorders like uncontrolled diabetes, compromised heart function
Analysis of a Population in Extreme Age of Life With a Hip Fracture

Observational retrospective study of pacients over 95 years admitted in traumatology ward with a osteoporotic hip fracture


Eligibility Criteria:
Inclusion Criteria:

* osteoporotic hip fracture

Exclusion Criteria: