cyrilzakka/clinical-trials huggingface dataset:
Reiki Effects on Bone Marrow Transplant Patients

The aim of the study is to examine the effect of Reiki on fatigue, vital signs, and engraftment in bone marrow transplant patients.

Cancer is a serious and chronic disease, the number of which is increasing rapidly in our country and in the world. Today, cancer accounts for 70% of all disease diagnoses and it is estimated that the number of new cancer cases will rise to 22 million in about twenty years.

Although hematopoietic stem cell transplantation is a promising treatment for remission and complete recovery in cancer patients, the symptoms after transplantation seriously affect the quality of life of individuals. In addition to psychosocial problems, patients experience serious physical problems such as suppression of the immune system and fatigue after transplantation. Energy therapies are widely used to provide general health and well-being and to reduce or relieve the symptoms of many chronic diseases. As a result of many studies on conditions such as fatigue, pain, and anxiety, it has been determined that Reiki energy has a positive effect. When we searched the literature, it was seen that there were not enough studies examining the fatigue, vital signs, and immune systems of bone marrow transplant patients.

This randomized controlled prospective study is conducted with bone marrow transplant patients between August 2022 to February 2023. The data of the study will collect using "Personal Information Form (PIF)", "Visual Analog Scale (VAS)", and "National Cancer Institute (NCI) -Common Terminology Criteria for Adverse Events (CTCAE)". Also, vital signs and laboratory findings will be recorded.

PIF, VAS, and CTCAE will be applied to the patients who meet the inclusion criteria. Patients will be randomized 1:1 into groups to the block randomization method. There are two arms in the study; Reiki (n=21) and control group (n=21). A second-degree Reiki practitioner will apply Reiki to the patients for 30 minutes. on the second day and the third day, 30 minutes distance Reiki will be applied to the patients. In the control group, nothing will be done. Post-tests will be applied to all patients after one week and vital signs and laboratory findings will be recorded.

Eligibility Criteria:
Inclusion Criteria:

* Being over 18 years old
* Not having a communication problem,
* Autologous bone marrow transplantation has been performed
* Willingness to participate in Reiki practice,
* To be competent to answer the data collection tools to be used in the research.
* Not using complementary practices (energy therapies) in the last six months.

Exclusion Criteria:

* Having a communication problem
* Application of allogeneic bone marrow transplantation
* Not being willing to engage in Reiki practice
* Reiki practitioner or instructor,
* Have received energy therapy sessions such as Reiki/Therapeutic touch/Healing touch in the last six months
* Application of bone marrow transplantation for hematological cancers
A Feasibility and Acceptability Pilot Study Evaluating a Patient-Specific Targeted Intervention Using Patient Navigators or Routine Clinical Care

Project Lets start will provide individual support to breast cancer patients with the goal of reducing delay to chemotherapy initiation. In this study participants will identify areas of need and work with patient navigators who will provide weekly 1-1 support throughout patient's journey to beginning chemotherapy

OBJECTIVES:

Among patients with early-stage breast cancer, delays with the administration of chemotherapy significantly reduce its benefit. Interventions aimed at reducing TTC have the potential of improving outcomes and reducing health disparities. In this study we propose to develop an effective targeted intervention that is culturally sensitive and that addresses the roots of chemotherapy delay.

Our objective is to conduct a pilot study randomizing patients with breast cancer, in whom adjuvant or neoadjuvant chemotherapy has been recommended, to a culturally sensitive and patient-specific targeted intervention using patient navigators or routine clinical care

Primary Aim: To establish feasibility and acceptability.

We hypothesize that the intervention will be feasible and accepted by participants.

Secondary Aim: Explore TTC according to treatment arm. We hypothesize that the TTC will be shorter among participants randomized to the intervention

Exploratory Aim: 1) To determine if social support, interpersonal trust in a physician, and general self-efficacy changed from baseline to the end of the intervention; and 2) to determine if that change was similar between participants randomized to the intervention compared to the control arm.

We hypothesize that there will be favorable changes in scores among participants randomized to the intervention, while no change will occur among those randomized to the control arm.

Eligibility Criteria:
Inclusion Criteria:

I. At least 18 years of age. II. Diagnosis of primary invasive breast cancer. III. Chemotherapy (adjuvant or neo-adjuvant) recommended by treating physician (including pregnant women in 2nd or 3rd trimester).

IV. Patient of the University of Texas MD Anderson Cancer Center or planning on receiving treatment at our Institution.

V. Can speak, read, and understand English and/or Spanish. VI. Participant can provide consent for themself

Exclusion Criteria:

I. Hospitalized for a critical condition or who are considered medically unstable by their medical team.

II. Patients that have been previously treated with chemotherapy.
Contractile Cross Sectional Areas and Muscle Strength in Patients With Congenital Myopathies

Patients with inherited muscle diseases can have several problems in their muscles, which can be both structural and metabolic. All the different diseases can affect the contractility of the muscles. The aim of the study is to investigate the relation between muscle strength and contractile cross sectional area (CCSA) in the thigh and calf in patients affected by inherited muscle diseases.

Patients with inherited muscle diseases can have several miscellaneous problems in their muscles, which can be both structural and metabolic. Depending on the specific disease multiple symptoms may be present. All the different diseases can affect the contractility of the muscles. Examples of inherited muscle diseases are congenital myopathies and RYR1-myopathy, afflicting the muscle fiber structure. They are the first subgroups of inherited muscle diseases to be investigated in this study. Congenital myopathies are hereditary and relatively non-progressive diseases. Hypotonia is the clinical characteristic of congenital myopathies and is often presented already in the neonatal period. Almost all patients have generalized muscle weakness and hypotonia. The various subtypes of congenital myopathy are a broad group of disorders defined by the predominance of particular and specific structural abnormalities shown in muscle biopsies. Based on genetic and morphological features, they can be divided into four main groups; one with central cores, one with central nuclei, one with minicores and one with nemaline bodies. RYR1-myopathy is caused by a mutation in the RYR-gene. The RYR1-protein is important in the making of RYR1-receptors and channels responsible for the transport of calcium atoms within muscle cells, particularly in muscle contractions. Patients typically present with limb weakness, decreased fetal movement and skeletal abnormalities. About 70% of patients with malignant hyperthermia have a mutation in the RYR1-gene. MRI findings often include involvement of different muscles in the thigh and the calf.

Eligibility Criteria:
Inclusion Criteria:

* Verified inherited muscle disease.
* Age: Over 18 years old

Exclusion Criteria:

* Contraindications for an MRI.
* Claustrophobia.
* Pregnant or nursing women.
* Competing disorders (as arthritis) or other muscle disorders.
Effect Analysis of Neoadjuvant Chemoradiotherapy Combined With Surgery in Laparoscope for Advanced Colon Cancer

In this study, a randomized controlled trial was conducted on advanced colon cancer patients with preoperative tumor staging T1-4/N1-2/M0 or T4/N0/M0 to determine the effectiveness of preoperative short-term radiotherapy combined with chemotherapy and whether it can effectively reduce the postoperative local recurrence rate, so as to provide better treatment for colon cancer patients and improve the oncological treatment effect of colon cancer.

This is prospective,a single-arm, single center, clinical trail study.The patient entered the study after meeting that criteria.The ORR, R0 resection, OS and DFS of patients and neoplasm down-staging status,etc would be compared.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of colon neoplasm
* 18 years to 70 years
* Preoperative abdominal enhanced CT or MRI showed cT4, cN0-2
* ECOGS score≤2
* thoraco-abdomina CT showed no obvious metastasis（The CT of liver and lung show uncertainty tubercle,suggestive performed PET-CT) cT4,cN0-2,M0 radiography Inclusion Criteria（according postoperative enhanced CT or MRI）
* progress tubercle penetrate peritoneotome base
* progress tubercle penetrate serous surface of neighboring organ
* progress tubercle development by late mesentery or side abdominis

Exclusion Criteria:

* Appeared other system cancer
* Patient with postoperative recurrent of colon cancer
* Patient with malignancies history in recent 5 years
* Pregnant or female of suckle period
* The patient have adjuvant radiotherapy record in other system cancer before this time treatment，and Patient with surgical contraindications.
* The patient have accepted adjuvant chemoradiotherapy before this time treatment.
* Distant metastasis found during surgery
* Patients with poor radiotherapy compliance and difficulty in coordination
* Patients with mental disorders
Attempted Suicide With Acetaminophen Among 8-18 Year-old Children / Adolescents in Denmark

A: Early predictors of hepatic injury after suicide attempt with acetaminophen:

To explore the following in a pediatric population with acetaminophen overdose due to suicide attempt: 1) the prevalence of episodes of pre- and in-hospital vomiting and the relationship between the total number of vomiting episodes and hepatic injury, 2) the relevance of the early initiation of N-acetylcysteine (NAC) treatment to hepatic injury, and 3) the presence/absence of illness prior to the suicide attempt and hepatic injury.

B: Characteristics, social behaviour, trends and risk factors:

1. To explore the relationship between children admitted to a paediatric department as a result of suicide attempts with acetaminophen and their parents and friends. 2. To determine the extent to which the children had attempted to speak to their parents or other adults about their problems before their suicide attempts. 3. To determine the prevalence of self-mutilation among children with suicidal behaviour. 4. To examine the reasons for these suicide attempts.

C: Establishment of the expression of cytochrome P450 in a pediatric including the age-adjusted activities.

Urine samples will be analyzed using an HPLC tandem mass spectrometric method, which we have already established in our lab.

There will be categorized three groups for comparison:

1. An age-appropriate background population (approximately 200 patients)
2. Paediatric patients that have been admitted to Rigshospitalet, due to severe hepatic injury (approximately 50 patients)
3. Other pediatric patients admitted to their local hospital because of acetaminophen poisoning (approximately 200 patients) A control urine sample will be analyzed three months after the suicide attempt.


Eligibility Criteria:
Inclusion Criteria:

* 8-18 years-old, who tried to commit suicide with acetaminophen.
* Children are only included if they have answered all our standard questions.

Exclusion Criteria:

* Children with known liver disease prior to the suicide attempt.
* If a child have several suicide attempts during the inclusion-period, only the 1st will be included.
* Suicide attempts with other agents than acetaminophen.
* Children taking medication that enhance the induction of the cytochrome P450 system, increase the production of toxic metabolites, and aggravate the hepatic injury, such as ethanol, rifampin, isoniazid, barbiturates, and carbamazepine, will be excluded.
Performance Under SGLT-2-Inhibitors in Humans

The PUSH Study is conceived to investigate the early effects of SGLT-2-Inhibitors on the physical performance of patients with Type-II-Diabetes mellitus compared to patients under other therapy regimes. Patients shall be divided into 3 groups: I - Patients with type II diabetes mellitus under new treatment with an SGLT2-Inhibitor. II - Patients with type II diabetes mellitus without SGLT-2- Inhibitor medication. III - Patients without type II diabetes mellitus but with similar comorbidities to the previous groups.

SGLT-2-Inhibitors have been shown to improve cardiovascular outcomes in patients with type II diabetes mellitus. Present evidence shows this effect to be not directly related to better serum glucose levels because the effect was measurable within several days of initiation of the treatment.

In a prospective single-centre double-blinded comparative observational study, other aspects of the effect of SGLT-2-Inhibitors shall be analyzed from patient registry, particularly the physical performance of patients under new treatment with SGLT-2-Inhibitors. Patient consent will be sort for the analysis of clinical data during the duration of stay.

Patients included in the registry suitable for analysis shall be divided into 3 groups: I - Patients with type II diabetes mellitus under new treatment with an SGLT2-Inhibitor. II - Patients with type II diabetes mellitus without SGLT-2- Inhibitor medication. III - Patients without type II diabetes mellitus but with similar comorbidities to the previous groups.

Eligibility Criteria:
Inclusion Criteria:

* informed consent
* ambulatory patients

Exclusion Criteria:

* relevant limitations in movement
Study of the Relationship Between Serum Adiponectin and Clinical Prognosis in Patients Undergoing Cardiac Surgery

The purpose of this study is to investigate the relationship between serum adiponectin and clinical prognosis in patients undergoing cardiac surgery.

Adiponectin, an adipose tissue derived protein, is an abundant protein hormone regulatory of numerous metabolic processes. Since its discovery, adiponectin has garnered considerable attention for its role in cardiovascular pathology. It has been shown to be a predictor of cardiovascular events in both the general population and patients undergoing cardiac surgery. In this study,we are planning to investigate the relationship between serum adiponectin and clinical prognosis in patients undergoing cardiac surgery.

Eligibility Criteria:
Inclusion Criteria:

* Patients who had underwent cardiac surgery from July 2011 to August 2012 in xijing hospital.

Exclusion Criteria:

* Nothing particular.
Health Promotion in the Elderly--Prevention of Cardiovascular Disorders

To develop an epidemiologic model to estimate the benefits, costs and risks of disease prevention in the elderly.

DESIGN NARRATIVE:

The investigators extended work they had done in modeling the health benefit of reducing risk factors for cardiovascular disease. Their new model incorporating risks of importance in the elderly, including cerebrovascular disease, estimated both morbidity and mortality averted by risk reduction, and estimated the costs and risks of the interventions used to modify risk factors.

The model was designed for the counseling of elderly individuals free of cardiovascular disease, and evaluated strategies for remaining disease free. It was implemented as software running on personal computers, and marketed to physicians and other health professionals who advised the elderly on medical issues. Accompanying documentation was also developed to explain the assumptions and non-quantifiable aspects of the decision to adopt major lifestyle changes to reduce risk.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility Criteria:
No eligibility criteria
Barrow Nasal Inventory Survey

The purpose of this study is to evaluate patient nasal outcome following endo-nasal surgery. This type of surgery is conducted for pituitary and skull base tumors. There is no published data on trauma to the nose during surgery and how it impacts nasal functioning. The investigators propose to develop a survey and administer it to patients before and after surgery to learn about their perception of nasal functioning.

A 9-item patient survey (the ASK Nasal Inventory) focusing on the most common postoperative complaints, such as crusting, sinusitis, pain, and ease of breathing, was developed by the anterior skull base team at the Barrow Neurological Institute. Content was validated in structured patient interviews by four subject-matter experts with both endonasal and control groups. Eligible patients for the control group included patients undergoing any neurosurgical procedure requiring anesthesia that did not involve the endonasal corridor, such as spinal decompression procedures, craniotomies for trigeminal neuralgia, and shunting procedures. This survey was self-administered pre- and 3 months post-surgery.

Eligibility Criteria:
Inclusion Criteria:

* Adults with planned endonasal surgery for pituitary tumor or skull base lesion

Exclusion Criteria:

* Children
Cascade CGM 15-day Performance Assessment

To validate the feasibility of a 15-day wear period of the Cascade CGM system

To assess a 15-day wear period for the Cascade CGM. This study includes ten subjects who will interface with the system and take finger stick BGM glucose values for calibration. The wear period includes four in-clinic days frequent blood draws and eleven at home days at a single testing site.

Eligibility Criteria:
Inclusion Criteria:

* • Signed informed consent form

  * Diagnosis of type 1 or type 2 (on insulin therapy) diabetes mellitus for at least 6 months
  * 18 years of age or older
  * Currently self-monitoring capillary blood glucose (on average at least three times per day or more) or on a CGM for at least three months
  * Willing to have blood glucose levels manipulated into high and low glucose levels during in clinic days if deemed appropriate per the protocol based on insulin use.
  * Willing to follow all study procedures, including attending all clinic visits during which a venous line will be inserted for blood sampling, wearing CGM sensors for entire study, performing fingertip glucose tests for self-monitoring and calibration, and keeping a diary of activities.
  * Be willing to wear two investigational CGM devices.

Exclusion Criteria:

* • Known allergy to medical grade adhesives

  * Magnetic Resonance Imaging (MRI) scheduled during CGM sensor wear period
  * Persons with type 2 diabetes using diet and exercise only for diabetes management
  * Used an investigational drug within 30 days prior to study entry
  * Hematocrit \< 32% (obtained during screening)
  * Inadequate veins (in the opinion of the investigator) or known contraindication to placement of a dedicated peripheral line for venous blood withdrawal
  * Symptomatic coronary artery disease with a history of angina, or history of a myocardial infarction or coronary intervention (e.g., percutaneous transluminal coronary angioplasty \[PTCA\], stent placement), or coronary artery bypass graft (CABG) within the past six months
  * Diagnosis of the following diabetic autonomic neuropathies: orthostatic hypotension, heart rate anomalies, gastroparesis
  * Cerebrovascular incident within the past six month
  * History or presence of eczema, psoriasis, atopic or contact dermatitis
  * Subject is pregnant at the start of the study.
  * Current use or within one-week exposure to topical medications at the proposed insertion sites
  * Seizure disorder (epilepsy)
  * Malignancy within the past five years, except basal cell or squamous cell skin cancers
  * Major surgical operation within 30 days prior to screening
  * Other medical conditions that would pose safety concerns, interfere with study conduct or seriously compromise study integrity (reason for exclusion will be clearly documented by investigator or designee)
Sequential Practicing on Psychomotor Skill Acquisition in Undergraduate Dental Students

To determine the influence of hand practice sequence on psychomotor skill acquisition in a glass ceramic onlay preparation among undergraduate dental students.

Effect of bilateral transfer practice on psychomotor skill acquisition among dental students remains unresolved. Bilateral transfer assumed that training one side of the body can also improve performance on the other side. Eligible participants are fourth- to sixth-year undergraduate dental students at the Faculty of Dentistry, Chulalongkorn University during the 2024 to 2025 academic year. The participants were categorized as left- or right-handed based on self-reporting. Participants enrolled two-day study with one-week separating inverval. On the first day, they learn a video presentation on glass ceramic onlay preparation followed by two practice sessions with 2-hour within each session. The practice start with either using non-dominant or dominant hand, followed by the use of non-dominant hand. One week later, they enroll two-hour practical examination on glass ceramic onlay preparation using their non-dominant hand. No practice is allowed during one-week separating interval.

Eligibility Criteria:
Inclusion Criteria:

1. The fourth- to sixth-year undergraduate dental students at a single setting of school
2. The fifth- and sixth-year students had completed laboratory and lecture courses in operative and fixed dental prosthodontics
3. The fourth-year students are enrolled in their final laboratory and lecture courses in fixed prosthodontics.

Exclusion Criteria:

Undergraduate dental students who have prior experience with onlay preparation in laboratory or clinical settings or those who are unwillingness to adhere to the study protocol.