cyrilzakka/clinical-trials huggingface dataset:
Serum IL-17 Correlated With Inflammatory Changes in Osteoarthritis and Rheumatoid Arthritis

The total number of the included subjects was 120 in 3 equal groups (RA, OA and control). All subject was subjected to serum IL17 level measurement. MSK US (of both wrists, MCPs, PIPs and DIPs) was done to all patients in RA and OA groups. Disease activity was measured by disease activity score (DAS28) for RA patients. Visual analogue scale for pain (VAS) was obtained from patients in RA and OA groups. Functional assessment was done using health assessment questionnaire (HAQ) for RA patients and the Australian/Canadian (AUSCAN) Osteoarthritis Hand Index for OA patients


Eligibility Criteria:
Inclusion Criteria:

* A patient is considered having definite RA if he/she scores at least 6 points in the established classification system
* A patient is considered having Hand OA if he /she Hand pain, aching, or stiffness plus 3 or 4 of hard tissue enlargement of 2 or more of 10 selected joints or hard tissue enlargement of 2 or more DIP joints or fewer than 3 swollen MCP joints, or deformity of at least 1 of 10 selected joints which are are the second and third distal interphalangeal (DIP), the second and third proximal interphalangeal, and the first carpometacarpal joints of both hands

Exclusion Criteria:

* Any subject with liver diseases, coronary artery diseases, kidney diseases or other inflammatory conditions was excluded from the study.
VR Education in Arterial Hypertension

The aim of this study is to compare standard education with VR augmented education in patients with arterial hypertension

To demonstrate the technical and organizational feasibility of patient education about arterial hypertension in virtual reality. Demonstrate the non-inferiority of education conducted in virtual reality to traditional face-to-face education by a physician. To define the cost-effectiveness of education in virtual reality in the reality of progressing shortage of human resources.

Patients diagnosed with arterial hypertension as part of a routine examination in an internal medicine outpatient clinic will be randomized to education about the disease directly by a physician in one arm or using a 3D movie in VR glasses filmed by a physician in an identical outpatient clinic setting. It will be concluded by questionnaire method to compare the outcome of both education namely subjective satisfaction and objectively by using questions to evaluate the success of the education.

Eligibility Criteria:
Inclusion Criteria:

* all consecutive patients with arterial hypertension

Exclusion Criteria:

* visual impairment
Exploration of Sensory-motor Representations in Children of Typical Development Aged 5 to 8

Evaluate the quality of sensorimotor representations in typically developing children aged 5 to 8 years.

The early coupling of perception and action makes it possible to build the sensorimotor representations, necessary for the functions of anticipation, adaptation and learning which will allow a harmonious development of motor skills throughout ontogenesis. One of the current hypotheses to explain the learning disorders detected in elementary school is a defect in the development of sensorimotor representations. Our study therefore aims to assess the quality of sensorimotor representations in typically developing children aged 5 to 8 years, using a motor imaging protocol, conventionally used in the literature in adults and patients. child. This motor imagery protocol consists of comparing the time taken by the subject to perform a given action and the time taken to imagine the action he has just performed. More precisely, the mental chronometry paradigm, based on the similarity or the difference between the two durations, makes it possible to assess the robustness of sensorimotor representations. While this isochrony is widely reported in the literature in adults, developmental studies describe onset around 9-10 years of age. Currently there is a lack of data to know the construction of these sensorimotor representations in younger children, especially during the transition to primary school. The originality of our protocol lies in two points: 1. the proposed tasks are particularly suited to young children and 2. the subject himself times his performance in the two situations: action carried out and action imagined. The duration of the experience will last 1 hour per participant in a single session.

Eligibility Criteria:
Inclusion Criteria:

* Child aged 5 to 8
* Child enrolled in accordance with his age
* No sensory abnormality identified
* No neurodevelopmental abnormality identified

Exclusion Criteria:

* Child not affiliated to a social security scheme.
* Refusal to participate by parents and / or child
Digital vs Conventional Impressions Study

This study aims to compare how a single cap best fit on a tooth that is fabricated with digital and conventional impression techniques.


Eligibility Criteria:
Inclusion Criteria:

* Age of patient ≥ 18 years old
* Good oral hygiene and compliance
* In need of a single full-coverage crown on any vital premolar or first molar tooth
* Opposing tooth is free of indirect restoration (crown)
* Asymptomatic tooth free of pathology
* No requirement for additional treatment (endodontic treatment, post and core, crown lengthening)
* Anticipated supragingival or equigingival crown margin
* Anticipated crown margin on natural tooth structure
* Adequate abutment height after tooth preparation (minimum 4mm)

Exclusion Criteria:

* Age of patient less than 18 years old
* Poor oral hygiene and calculus on sample teeth
* In need of a single full-coverage crown on tooth other than a vital premolar or first molar tooth
* Opposing tooth is restored with indirect restoration
* Periapical or periodontal pathology
* Anticipated pulp exposure or need for additional treatment (endodontic treatment, post and core, crown lengthening)
* Anticipated subgingival crown margin
* Anticipated crown margin on direct restoration
* Inadequate abutment height after tooth preparation
Effect of Dexamethasone as an Adjuvant to Bupivacaine in Bilateral Erector Spinae Block on Postoperative Pain and Diaphragmatic Function After Pediatric Cardiac Surgeries : A Randomized Controlled Clinical Trial

The aim of this study is to figure out the efficacy of dexamethasone addition to bupivacaine versus bupivacaine alone in bilateral erector spinae plane block on postoperative analgesia after pediatric cardiac surgeries

The recently introduced ultrasound-guided interfascial plane block, bilateral erector spinae plane block (ESPB) is a viable option for management of postoperative pain after midline sternotomy. It is expected to provide an analgesic cover spanning the entire thorax at the desired dermatomes including the midline, which could prove beneficial for cardiac surgery through midline sternotomy.

Indications for ESPB for postoperative analgesia in pediatric surgeries to date include thoracotomy, video-assisted thoracoscopic surgery, vascular ring repair and sternotomy.

Dexamethasone is a synthetic glucocorticoid acting as an anti- inflammatory. It inhibits the release of inflammatory mediators such as interleukins and cytokines. Several studies have shown that a preoperative dose of dexamethasone added to local anesthetic agents has promising results in reducing postoperative pain and improving the quality of analgesia

Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status I and II
* Undergoing cardiac surgical procedures through a midline sternotomyPreoperative ejection fraction \<35%

Exclusion Criteria:

* Low-cardiac-output syndrome
* Ventricular arrhythmia
* Preoperative inotropic support
* Known allergies to any of the study drugs
* Intubation for more than 3 hours or re-exploration
* A redo or emergency surgery
* Contraindications to regional anesthesia as coagulopathy and infection in site of block.
Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction

Study to evaluate if macitentan is safe and tolerable enough to be used for treatment of subjects with combined pre- and post-capillary pulmonary hypertension (CpcPH) due to left ventricular dysfunction.


Eligibility Criteria:
Inclusion Criteria:

1. Males and Females \>=18 years of age
2. Subjects with combined pre-and post-capillary Pulmonary Hypertension (CpcPH) due to left ventricular dysfunction (subset of WHO groups 2.1 and 2.2)
3. Optimized diuretic therapy

Exclusion Criteria:

1. Types of Pulmonary Hypertension other than WHO groups 2.1 and 2.2 (Nice classification)
2. Administration of PAH-specific therapy (i.e., Endothelin receptor antagonists (ERAs), Prostanoids, Phosphodiesterase 5 (PDE-5) inhibitors, guanylate cyclase stimulators)
Linked Color Imaging (LCI) for Colorectal Adenoma Detection

Linked color imaging (LCI) is newly developed image-enhancing endoscopy technology that differentiates the red color spectrum more effectively than white light imaging thanks to its optimal pre-process composition of light spectrum and advanced signal processing. This technology, combined in the latest generation Fujifilm's endoscopes (Fujifilm Co, Tokyo, Japan) with new high-performance LED illumination system, enhances the visibility of colonic mucosal vessels and might increase the detection rate of colorectal polyps. Data available regarding colorectal polyp or adenoma detection with LCI are encouraging but are scanty and limited to back-to back studies.

This two parallel arms, randomized, multicenter trial is aimed at evaluating whether LCI is superior to WL endoscopy in terms of adenoma detection

50-75 years-old subjects participating in the regional screening program undergoing their first colonoscopy following a positive immunochemical fecal occult blood test (FIT) and meeting all eligibility criteria are randomised 1:1 to LCI (LCI group) or WLI (WL) during insertion and withdrawal phase of colonoscopy. A randomisation list for each participating center was produced by the coordinating center via computer-generated treatment code list. Randomisation is stratified by gender, age (50-60, 61-729 years) and screening history (first vs subsequent test) through an online centralised study database.All procedures are performed with a high-definition ELUXEO 700 series videocolonscopes with or without magnification (EC-760R, EC-760ZP, FUJIFILM Co., Tokyo).

The primary outcome measure is the ADR, defined as the proportion of participants with at least one adenoma (per-patient analysis).

Eligibility Criteria:
Inclusion Criteria:

* 50-75 years-old subjects participating in the regional screening program undergoing their first colonoscopy following a positive immunochemical fecal occult blood test (FIT)

Exclusion Criteria:

* subjects not eligible for invitation in the screening program (colonoscopy already performed in the previous 5 years, personal history of CRC, colonic adenomas or IBD, severe comorbidity, including end-stage cardiovascular, pulmonary, liver or renal disease)
* patients with inadequate bowel preparation (defined as Boston Bowel Preparation Scale \> 2 in any colonic segment)
* patients with previous colonic resection
* patients on antithrombotic therapy, precluding polyp resection
* patients who were not able or refused to give informed written consent.
Auriculotemporal Nerve Block in TMJ Disorders

The retrospective study aimed to evaluate the efficacy of the Auriculotemporal Nerve Block (ATNB) in achieving unrestricted mouth opening amount and in reducing the pain scores in those patients diagnosed with disc displacement with (DDWR) and without reduction (DDWOR) according to the Diagnostic Criteria for Temporomandibular Disorders, who could not benefit from noninvasive methods but did not want further invasion.

The records of 410 patients referred to the Department of Oral and Maxillofacial Surgery with TMD symptoms were reviewed to determine the treatment modalities used and their outcomes. The subjects were examined and diagnosed according to the Turkish translation version of The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD-Axis 1 questionnaire and examination form). The pain intensity, maximal mouth opening (MMO) amounts, and self-reported outcome variables of twenty-two patients who underwent non-invasive therapies (occlusal stabilization splints, behavioral modifications, physical therapy, pharmacotherapy) but did not benefit from them and volunteered for the ATNB instead of invasive therapies (arthrocentesis, arthroscopy, and discectomy) were also evaluated. Prior to the ATNB, written informed consent was obtained from each participant. Also, each participant was warned about complications of the ATNB before the administration, such as hematoma at the injection site, positive aspiration, and temporary anesthesia of the facial nerve.

Eligibility Criteria:
Inclusion Criteria:

* Underwent non-invasive therapies (occlusal stabilization splints, behavioral modifications, physical therapy, pharmacotherapy) but did not benefit from them and volunteered for the ATNB instead of invasive therapies (arthrocentesis, arthroscopy, and discectomy).

Exclusion Criteria:

Patients with

* Symptoms of the diseases possibly related to TMD (e.g., fibromyalgia, hypothyroidism, scleroderma, rheumatoid arthritis)
* Orofacial disorders that might have been responsible for the TMD symptoms (e.g., neuralgia, migraine, myositis, trauma, neuropathic pain, infections)
* Complications due to ATNB (e.g., temporary facial nerve palsy, hematoma, positive aspiration)
* History of invasive therapies or TMJ surgeries
An Ischaemic Stroke Observational Study

A non-interventional observational clinical study to document the clinical course of patients at 12 months or more following an ischaemic stroke

Primary objective:

To document and better define the prognostic characteristics of residual disability 12 months or more following an ischaemic stroke in patients that originally participated in the preceding clinical study RN-CS-0001.

Other objective:

To inform the design of efficient Phase 2/3 studies when screening potentially efficacious interventions for signals of activity which merit further development.

Eligibility Criteria:
Inclusion Criteria:

* Capacity to give informed consent or witnessed informed consent in the event that the patient is unable to sign informed consent due to physical impairments.
* Participation in the preceding study RN-CS-0001
* Completion of at least one of the 4 functional assessment tests (ARAT, BI, NIHSS, mRS) at any time point on the previous study RN-CS-0001
* Ability to participate in all assessments and attend all visits

Exclusion Criteria:

* Any additional incidence of stroke (Ischaemic or Haemorrhagic) since participation in the previous study RN-CS-0001 (since the last CS-0001 assessment visit date).
* Incidence of significant other disease that judged by the investigator would confound completion of all functional assessments (not excluding patients that can complete at least one functional assessment with no confounding factor from significant other disease).
Investigating Muscle Failure in Diabetic Myopathy

The goal of this observational study is to assess if diabetes and obesity are independently related to functional and structural muscle deficits, and how muscular deficits relate to metabolic properties of diabetes and obesity. All studies will include clinical muscle strength and contractile examinations, functional tests, and MR imaging and spectroscopy techniques.

The main questions this project aims to answer are:

1. Is chronic hyperglycemia in type 1 and 2 diabetes associated with functional and structural deficits of skeletal muscles unrelated to the presence of neuropathy?
2. Is obesity associated with functional and structural impairments of skeletal muscles unrelated to the presence of type 2 diabetes ?
3. Does weight loss improve muscle metabolic flexibility and economy and modify skeletal muscle function and structure in obese subjects with and without type 2 diabetes?

The project will include three studies, intended to answer the hypotheses listed above:

Study 1: Evaluation of functional and structural muscular deficits of diabetic myopathy in relation to prolonged hyperglycemia prior to and 6 months following glycemic improvement in patients with type 1 and 2 diabetes

Study 2: Functional and structural muscular deficits in severely obese subjects with and without type 2 diabetes prior to assisted weight loss.

Study 3: Changes in functional and structural muscle properties following assisted weight loss in severely obese subjects with and without type 2 diabetes - a 1-year follow-up study.


Eligibility Criteria:
Inclusion Criteria:

Study 1:

* Age: 18-60 years
* BMI: 18.5 - 39, minimum weight = 50kg
* Chronic hyperglycemia: HbA1c of ≥ 70 mmol/mol with a duration of ≥ 2 months prior to enrollment
* Physical activity: Less than 3 x 60 min of structured physical activity per week

Study 2 \& 3:

* Age: 25-60 years
* BMI: ≥ 35
* Physical activity: Less than 3 x 60 min of structured physical activity per week

Healthy Control Participants:

* Age: 18-60 years
* BMI: 18.5 - 30, minimum weight = 50kg
* Physical activity: Less than 3 x 60 min of structured physical activity per week

Exclusion Criteria:

Study 1, 2, 3 and healthy controls:

* Diabetic neuropathy with expected motor deficits
* Uncontrolled cardiovascular or pulmonary disease, peripheral vascular disease, osteoarthropathy of the lower extremity, or any neurological og rheumatological disease which may affect muscle function, as well as any other disease that may effect ones ability to perform physical activity.
* Any Magnetic Resonance contraindications
* Any condition that by the principal investigator is expected to affect the participants ability to execute the study elements

Specifically for healthy control participants:

* The presence of diabetes or pre-diabetes (HbA1c ≥42 mmol/mol)
Neoadjuvant Chemotherapy Followed by Radiotherapy Alone in Patients With Breast Cancer

After neoadjuvant chemotherapy, patients normally receive either conservative breast surgery or mastectomy followed by radiation therapy. Some patients achieve a complete response after neoadjuvant chemotherapy. Considering that radiation therapy is an effective treatment for subclinical microscopic disease, the question arises whether breast surgery before radiation therapy can be avoided in the subgroup of patients with complete response after neoadjuvant chemotherapy.


Eligibility Criteria:
Inclusion Criteria:

* Age 40 years or older
* Pathologically confirmed unicentric invasive breast cancer
* Clinical stage T1-3 / N0 or N2 / M0
* Clinical conditions to receive neoadjuvant chemotherapy

Exclusion Criteria:

* Prior diagnosis of cancer (exception: in situ cervical tumor and non-melanoma skin)
* Patient is known to be pregnant
* Prior history of radiation therapy in the thoracic region
* Impossibility to perform magnetic resonance imaging
Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. Here the investigators will directly measure the acute effects of Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.


Eligibility Criteria:
Inclusion Criteria:

* 18 to 39 years of age
* Habitual Hookah smoker defined as having smoked Hookah \>=12 times in the past 12 months
* Have not smoked cigarettes within the past 12 months

Exclusion Criteria:

* Exhaled carbon monoxide level greater than 10 ppm\* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours)
* History of cardiopulmonary disease
* Use of any prescription medication with exception of oral contraceptive pills
* History of psychiatric illness
* History of neurologic disease
* BMI ≥ 35
* Evidence of any of the above by physical examination, ECG or echocardiogram
* Smoked cigarette in the past 12 months
* History of illicit drug use
* Pregnant
* Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study
Ultrasound-guided Dual TAP Block: Magnetic Resonance (MR) Evaluation of the Distribution of Local Anesthetic

Using Magnetic resonance (MR) scanning and ultrasonography the investigators wish to investigate, in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

There has been much debate as to what extent the classical TAP block will anesthetize more than the frontal dermatomes (TH10-Th12/L1). Some cadaver studies have been performed with injection of dye in the classical TAP. However, it is still not clear whether a single injection of local anesthetic in the classical TAP block position will reach the more cephalad and medial intercostal TAP plexus (Th6-Th9). In this study the investigators use MR scanning and ultrasonography to investigate in what way a known volume of local anesthetic injectate will be distributed in the transverse abdominis plane (TAP) in young healthy male volunteers. The investigators compare the anatomical distribution of the local anesthetic injectate in the TAP when performing an ultrasound-guided classical TAP block and a Dual TAP block. The investigators also want to compare the spread of anesthetized frontal dermatomes when performing an ultrasound-guided classical TAP block and a Dual TAP block.

Eligibility Criteria:
Inclusion Criteria:

* healthy male
* 18 years old or more
* had no previous abdominal surgery
* no regular medication
* no coagulation disorders
* no claustrophobia

Exclusion Criteria:

* if the volunteer is not able to accept an uncomplicated administration of a classical (single) or dual TAP block