cyrilzakka/clinical-trials huggingface dataset:
Differences in Attentional Profile of Children Diagnosed With ADHD Versus Children Diagnosed With Other Mental Conditions

Attentional symptoms characterize both ADHD and other mental conditions in children.

The diagnosis is based on clinical psychiatric evaluation.

With the expanding knowledge regarding the neurobiological basis in ADHD the investigators have learned that attention is not a general property of the whole brain, but involves several coordinated networks. This knowledge promoted the scientific community to the stage in which scientists can recognize different types of attention domains.

in the current study, the investigators use computerized battery to separate between the different attention abilities and provide specific attentional profile. in this study the investigators aim to characterize different attentional profiles in children who are diagnosed with ADHD versus children who diagnosed with other mental condition (which are common differential diagnoses of ADHD)

Attentional symptoms characterize both ADHD and other mental conditions in children.

The diagnosis of ADHD is based on clinical psychiatric evaluation in different clinical situations the differential diagnosis is not straight forward and the clinician considers a common co-morbid conditions and common differential diagnoses.

With the expanding knowledge regarding the neurobiological basis in ADHD the scientific community have learned that attention is not a general property of the whole brain, but involves several coordinated networks. This knowledge promoted us to the stage in which scientists can recognize different types of attention domains. this knowledge raises the question - can the clinician use this knowledge to make the correct diagnosis based on specific attentional profile?

In the current study, the investigators use computerized battery in order to separate between the different attention abilities and provide specific attentional profile. in this study the investigators aim to characterize different attentional profiles in children who are diagnosed with ADHD versus children who diagnosed with other mental condition (which are common differential diagnoses of ADHD)

Eligibility Criteria:
Inclusion Criteria:

* age 8-12
* normal intelligence quotient (IQ)
* suspected ADHD

Exclusion Criteria:

* Autism Spectrum Disorder
* blindness
* deafness
* abnormal intelligence quotient (IQ) (below 70)
Posterior Parasagittal In-Plane Ultrasound-Guided Infraclavicular Brachial Plexus Block

Abstract

Introduction: The brachial plexus at the infraclavicular level runs deeper compared to its course proximally, giving rise to impaired needle visualisation due to the steep angle of needle insertion with the current ultrasound-guided approach. A new posterior parasagittal in-plane ultrasound-guided infraclavicular approach was introduced to improve needle visibility. However no further follow up study was done.

Methods: We performed a case series and a cadaveric dissection to assess its feasibility in a single centre, University of Malaya Medical Centre, Kuala Lumpur, Malaysia from November 2012 to October 2013. After obtaining approval from the Medical Ethics Committee, University Malaya Medical Centre, 18 patients undergoing upper limb surgery were prospectively recruited. A cadaveric dissection was also performed. The endpoints of this study were the success rate, performance time, total anaesthesia related time, quality of anaesthesia and any incidence of complications.

Introduction Our study focus on the ultrasound guided infraclavicular brachial plexus block, which is a cord-level block of the brachial plexus for surgical procedures below mid-humerus. The brachial plexus at this level runs deeper compared to its course proximally, giving rise to impaired needle visualisation due to the steep angle of needle insertion with the current ultrasound-guided approach (lateral para-sagittal in-plane technique).1

A new ultrasound-guided posterior approach parasagittal in-plane infraclavicular block was introduced to improve needle visibility.2 However no further follow up study was done.

Therefore, we performed a case series of 18 patients with a cadaveric dissection, to assess the feasibility of this approach.

Methods After obtaining ethics committee approval from the Medical Ethics Committee, University Malaya Medical Center, Kuala Lumpur, Malaysia (Chairperson Professor Dr. Looi Lai Meng; IRB reference no. 949.14 dated 17 October 2012, amendment no.1038.76 dated 19 December 2013) and written informed consent, 18 patients undergoing surgery of the elbow, forearm, wrist, or hand were prospectively recruited based on the criteria below.

Eligibility Criteria:
Inclusion Criteria:

* patient's age between 18 and 80 years old,
* American Society of Anesthesiologists (ASA) physical status I - III,
* body mass index (BMI) between 20 and 35 kg/m2 and
* planned for surgery of the forearm, wrist, or hand.

Exclusion Criteria:

* patient's inability to give consent to the study,
* pre-existing neuropathy,
* infection at the site of puncture,
* coagulopathy, and
* allergy to amides local anaesthetics.
Brain Activity in Epilepsy

Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.

The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.

The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.

Scientific objectives of the current project:

* To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks.
* Identifying pivotal regions for BMI applications and developing online decoding algorithms.
* Comparing neural recordings to fMRI activity

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 yo
* Epilepsy patients undergoing intracranial electrode placement.
* Able to understand the procedure involved and to consent.

Exclusion Criteria:

* Age \< 18 yo
* Pregnancy
Patient Characteristics, Feasibility, and Outcomes of a Home Mechanical Ventilation Program in a Developing Country

This study aims to describe the patient characteristics, feasibility, and outcomes of an home mechanical ventilation (HMV) program at a university hospital in Thailand.

Data will be collected on all patients who were discharged with HMV between October 2014 and August 2015 at Thammasat University Hospital. Data include sex, age, co-morbid diseases, clinical features, causes of HMV, mechanical ventilator and complimentary equipment characteristics, caregiver characteristics, ventilator and patient care costs, and morbidity and mortality outcomes of patients.

Eligibility Criteria:
Inclusion Criteria:

* All hospitalized patients requiring mechanical ventilation aged 18 or more years.

Exclusion Criteria:

* None.
Can Postpartum Depression Be Prevented With Care

This study was designed to eliminate postpartum insomnia and fatigue and reduce the risk of postpartum depression through the maintenance of structural, personal, and social integrity with holistic care under the guidance of Levine's conservation model for primiparous puerperal women who experience fatigue and are at risk of developing depression. : A single-blind pretest-posttest randomized controlled study. Women were called to the hospital on the 7th postpartum day and randomly assigned by a computer program to either the intervention group (n=56) or the control group (n=56). Participants did not know which group they were in.

A nursing care program was prepared for the intervention group under the guidance of Levine's conservation model. This program was applied with 7 home visits between the 8th and 80th postpartum days. Face-to-face training and training booklets were provided in home visits. As of the fourth home visit, Pilates exercises were performed. The women in the control group received routine care. Pretest and posttest data were collected with a personal data sheet, visual analogue scale for fatigue, Postpartum Physical Symptom Severity Scale, Postpartum Sleep Quality Scale, Edinburgh Postpartum Depression Scale, and Postpartum Support Scale.

Sleep quality improved for the primiparous puerperal women of the intervention group. They had reduced postpartum fatigue and increased energy; maintained their structural, personal, and social integrity; and had decreased risk of developing postpartum depression with the holistic care provided (all p\<0.001). A negative correlation was detected between the support subscale posttest total score from the Postpartum Support Scale and the posttest scores of the Edinburgh Postpartum Depression Scale for the women of the intervention group (r=-0.303; p\<0.05)

Eligibility Criteria:
Inclusion Criteria:

* primiparous;
* reading and understanding Turkish;
* normal term delivery;
* no risky situations during pregnancy or delivery;
* high score (≥65 points) from the Visual Analogue Scale to Evaluate Fatigue Severity (VAS-F),
* score of ≥12 points from the Edinburgh Postpartum Depression Scale (EPDS);
* episiotomy;
* hemoglobin value of at least 10.0 mg/dL;
* no current or past history of psychiatric illness.

Exclusion Criteria:

* inability to communicate
* unwillingness to participate in the research.
High-tone External Muscle Stimulation for Pain Reduction

Sciatica is a common pain problem that affects not only the patient but also constitutes a socioeconomic burden and thus affects the whole society. So far, current pharmacologic therapies are inadequate for many patients. Therefore, we evaluated application of high-tone external muscle stimulation (HTEMS) compared to transcutaneous electrical nerve stimulation (TENS) on radicular pain associated with sciatica.

Hospital patients (n=100) with chronic sciatica and stable oral analgesic regimen were included into this randomized controlled cross-over trial. Each intervention was administered for a period of 45 min 5 times within 10 days, with a 3-day wash-out period before cross-over. Health impairments had been assessed using the visual analog scales (VAS) for radicular pain before and after intervention and differences in radicular pain between groups were analysed with the Mann-Whitney test.

Eligibility Criteria:
Inclusion Criteria:

* sciatica due to degenerative spine disorders
* stable oral analgesic regimen

Exclusion Criteria:

* history of drug or alcohol abuse
* cardiac pacemaker or defibrillator
* pregnancy
Bioequivalence Study Between Two Oral Formulations of Naproxen 500 mg Tablets Under Fasting Conditions

Compare the rate and extent of absorption of two oral formulations of Naproxen Tablets, administered as a 1 x 500 mg tablet under fasting conditions.


Eligibility Criteria:
Inclusion Criteria:

* healthy men or women, non-smoker, 18 years of age or older
* willing to participate and sign a copy of the informed consent form

Exclusion Criteria:

* clinically significant illnesses or surgery within 4 weeks prior to study dosing
* body mass index greater than or equal to 30.0
* recent history of drug or alcohol addiction or abuse
* pregnant or lactating women
* history of allergic response to naproxen, NSAIDs, or other related drugs, or to heparin
* history of allergic reactions such as asthma, rhinitis, nasal polyps, urticaria, and hypotension associated with the use of aspirin or other NSAIDs
* history or known presence of gastrointestinal ulceration, bleeding and perforation
* use of tobacco products within 6 months prior to study dosing
* evidence of a clinically significant disorder or whose laboratory results were deemed to be clinically significant
* receipt of any drugs as part of a research study within 30 days prior to study dosing
Effect of Continuous Intra-airway Monitoring Under Visible Double-lumen Bronchial Catheter on Postoperative Complications of Lung Surgery

The incidence of postoperative pulmonary complications (PPCs) after thoracic surgery is as high as 30-50% \[1-6\], which is the main cause of postoperative morbidity, death and prolonged hospital stay. Optimization of risk factors in PPCs procedures is the focus of current research. Double lumen bronchial tube (DLT) is a commonly used lung isolation method for adult patients. It has the advantages of good lung isolation effect, sufficient exposure of the surgical field and easy to attract secretions in the airway. However, there are still some deficiencies in clinical precise positioning, long-term continuous detection during operation, early detection of catheter displacement and other emergencies. Continuous intra-airway monitoring is the main advantage of visual double-lumen bronchial catheter. It can quickly and easily determine the position of the catheter and quickly adjust the displacement, and timely and effectively clean up the secretion in the airway, which is conducive to the analysis and treatment of intraoperative hypoxemia. Whether these potential advantages can reduce the incidence of PPCs deserves our in-depth discussion. The research group randomly divided the patients who were scheduled to undergo thoracoscopic radical resection of lung cancer in the Union Hospital affiliated to Fujian Medical University into the test group (lung isolation with visible double-lumen bronchial catheter, continuous intra-airway monitoring and intervention) and the control group: (Pulmonary isolation was performed with visual double-lumen bronchial catheter, and only intra-airway video was performed without monitoring. The effect of continuous intra-airway monitoring under visual double-lumen bronchial catheter on postoperative complications of lung surgery was evaluated by Melbourne evaluation scale.


Eligibility Criteria:
Inclusion Criteria:

* 1. Age 18-80 years, BMI 18.5-28 kg/m2, male or female
* 2. Patients who are to undergo unilateral thoracoscopic resection of more than three lung segments or lobectomies
* 3. Patients who can be extubated with 35# and 37# double-lumen bronchial catheters after pre-anesthetic evaluation
* 4. Subjects voluntarily sign the informed consent form for this trial.
* 5. Patients or their caregivers are able to fill out the survey form and can correctly understand and cooperate with the postoperative rehabilitation instructions of the medical staff.
* 6. Patients have SPO2 ≥ 96% when inhaling air preoperatively

Exclusion Criteria:

* 1. Patients with limited ability to cooperate with the study, such as the presence of cognitive dysfunction, mental illness, speech impairment or severe visual impairment or hearing impairment
* 2.ASA ≥IV
* 3. difficult airway, abnormal tracheal development, main airway stenosis, tumor, tracheoesophageal fistula
* 4. Complex sleeve pneumonectomy, unilateral total pneumonectomy, bilateral lung surgery
* 5. Preoperative anemia, Hb≤100g/L
* 6. Serum albumin ≤ 35g/L
Contingency Management and Pharmacotherapy for Smoking Cessation

In total, 70 smokers will be randomized to: standard of care smoking cessation medication varenicline alone (an FDA-approved smoking cessation medication) or varenicline plus contingency management (CM) (a behavioral procedure with rewards for target behaviors, like smoking abstinence). Patients in both conditions will receive varenicline for 12 weeks with standard smoking cessation therapy and regular breath and urine sample monitoring for smoking. Patients assigned to CM will earn chances to win prizes for each breath sample that tests negative for smoking, and urine samples that test negative for smoking will result in even greater chances for prizes. More CM patients are expected to achieve and maintain abstinence than patients receiving varenicline alone.


Eligibility Criteria:
Inclusion Criteria:

* smoke \>10 cigarettes/day, with no abstinent period exceeding 3 months in past year
* expired CO of \>8 ppm
* self-reported desire to stop smoking
* \>18 years of age
* resting systolic BP\<160 mmHg and diastolic BP\<100 mmHg and otherwise in good health
* if on antihypertensive medication, have not changed medications in the past month and do not intend to change in next 3 months
* English speaking

Exclusion Criteria:

* receipt of smoking cessation treatment (behavioral or pharmacological) in past month
* serious or unstable medical disease in past 6 months, including myocardial infarction, cancer, congestive heart failure, kidney failure, stroke, or seizures
* evidence or history of allergic reactions contraindicating varenicline or clinically significant laboratory or electrocardiographic (ECG) abnormalities
* breastfeeding, pregnant or not using effective contraception if a woman of childbearing potential
* arm circumference of \>42 cm
* serious psychiatric illness in past 6 months (e.g., schizophrenia, psychosis, suicide risk, drug or alcohol dependence other than nicotine)
* use of tobacco containing products other than cigarettes in past month and do not agree to abstain from use of these products during study participation
* ongoing use of any of the following medications: nicotine replacement therapies, monoamine oxidase inhibitors, antipsychotics, mood stabilizers, or naltrexone
* in recovery for pathological gambling, due to potential similarity with prize CM, although no increases in gambling have been noted
Oldest-old Patients Anesthesia in Orthopedic Surgeries

Average life span, life expectancy, and the number of older people, aged 65 years and over, have increased during the last decades. As life expectancy increased, the rate of emergency and elective surgical interventions has also increased in the older age group. Although good health is required to reach an advanced age, over time, organ functions may deteriorate, and some challenges may develop that will negatively affect the balance of homeostasis. Stress, such as trauma or surgery, can cause deterioration in organ functions or aggravation of impaired functions. The risk of developing undesirable events is higher, due to the diminished reserve and function, during anesthesia applied to these patients. There is a limited number of studies in the literature about the relation between the anesthesia technique and morbidity and mortality in oldest old patients operated for orthopedic surgery. In this study, we aimed to analyze the data of the oldest-old patients operated on for orthopedic surgery between 2016-2022, retrospectively, and to investigate the relationship between anesthesia technique and adverse effects including morbidity and mortality.


Eligibility Criteria:
Inclusion Criteria:

* Aged 80 years and above
* Underwent orthopedic surgery

Exclusion Criteria:

* Those who had the operation with local anesthesia
Effect of Two Pilates-based Mat Exercise Programs on the Isometric Strength of Core Muscles in Healthy Men

Based on the current evidence, it is known that Pilates is an exercise technique that has been used mainly by women in sport, fitness and rehabilitation. Most research has been developed with women. The participation of men in the research studies is reduced and methodology rigor is low, therefore, there is insufficient evidence on the effects of this type of training in men, in addition, there are no studies that have proven the effects of a Pilates-based mat exercise with resistance band on strength of core muscles.

The main objective of this research is to identify the effects of a Pilates-based mat exercise program versus a Pilates-based exercise mat program with resistance band on the isometric strength of the core muscles in men 18 to 25 years.

Fifty-eight men will be randomly assigned to one of two Pilates exercise programs. Pilates-based mat exercise and Pilates-based mat exercise with Theraband® (blue color). Interventions will be performed three times a week for eight-weeks on alternate days. Half will perform Pilates-based mat exercise and the remaining 29 will perform Pilates-based mat exercise with Theraband®. Both groups complete eleven exercises from week one to four and twelve exercises from week five to eight.

Eligibility Criteria:
Inclusion Criteria:

* Healthy volunteers.
* Perform ≤150 minutes of aerobic exercise per week.

Exclusion Criteria:

* Perform any Pilates exercise previously.
* Smoker.
* History of asthma.
* History of diabetes.
* History of hypertension.
* History of cardiovascular disease.
* History of coronary heart disease.
* Arrhythmias.
* Under medical treatment with anticoagulants, beta-blockers, calcium antagonists, bronchodilators, and/or steroids.
* Psychological, neuromotor and/or osteo-muscular conditions that may affect participation in an exercise program.
* People with metal prosthesis.
Short-term Embolization Using Gelatin Particles for FloW ModulAtion During Y90 Radioembolization

The SEGWAY trial is a prospective, single-arm clinical study to evaluate the efficacy and safety of flow diversion to protect non-tumorous liver function using short-acting gelatin sponge particles during Yttrium-90 radioembolization of liver cancer.

Short-acting gelatin sponge particles will be used during radioembolization to protect normal liver tissue in patients with liver cancer whose treatment field encompasses a substantial portion of non-tumorous liver tissue. Recanalization of the embolized hepatic artery will be assessed by angiography within 30 minutes following the procedure. Suppression of Y90 microsphere delivery to the protected, non-tumorous liver tissue will be evaluated using Y90 PET-CT imaging, by comparing the protected regions to non-protected, non-tumorous regions within the perfused area. Enhanced tumor uptake of Y90 microspheres will be quantified using the tumor-to-normal liver ratio (TNR), calculated by comparing pre-procedure SPECT-CT with post-procedure PET-CT data. Finally, preservation of liver function in protected tissue relative to unprotected tissue will be assessed six months post-procedure using signal intensity ratios on hepatobiliary phase images obtained from gadoxetic acid-enhanced MRI.

Eligibility Criteria:
Inclusion Criteria:

1. Adults aged 19 years or older
2. Patients diagnosed with primary or metastatic liver cancer based on histological and/or radiological findings
3. Patients determined, following medical, surgical, or multidisciplinary evaluation, to be best treated by radioembolization
4. Patients with no history of local treatments (e.g., ablation, chemoembolization) to the same hepatic lobe within the past year
5. Child-Pugh class A
6. Eastern Cooperative Oncology Group (ECOG) performance status of 2 or lower
7. Patients whose treatment area, as determined by planning angiography, includes at least two liver segments
8. Patients for whom normal liver tissue constitutes 50% or more of the treatment volume

Exclusion Criteria:

1. Liver cancer with vascular invasion
2. For primary liver cancer, patients who have been diagnosed with a malignancy other than the primary liver cancer within 2 years prior to study enrollment
3. Patients who have undergone biliary-enteric anastomosis
4. Patients with an estimated lung dose of 30 Gy or higher on pre-procedure 99mTc-MAA imaging
5. Patients with a known contraindication to gelatin use