cyrilzakka/clinical-trials huggingface dataset:
Effect of Stellate Ganglion Block on Internal Mammary Artery Dynamics

This study aims to assess the effect of a stellate ganglion block on the flow and diameter of the internal mammary artery using the pulsatility index and transient time flowmetry(TTFM) in patients undergoing coronary artery bypass grafting.

The internal mammary artery (IMA) is the preferred graft for myocardial revascularization because of its superiority over venous grafts owing to long term patency, lower mortality rates and improved post-operative outcomes.

However, conduit spasm is a recognized complication of coronary artery bypass surgery mainly affecting the arterial conduits, a major concern that can lead to acute myocardial ischemia and may contribute to reduce graft patency.

Topical application or systemic administration of many pharmacological agents has been shown to reverse or prevent graft spasm, but side effects are reported with the use of these agents.

Various vasodilators that have been tried included various organic nitrates, calcium channel blockers, sodium nitroprusside (SNP) and papaverine.

Over the last few years, there were some studies, which investigated the effect of regional anesthesia techniques such as thoracic epidural anesthesia (TEA) and stellate ganglion block (SGB) for sympatholysis and studied its effects on internal mammary artery diameter .

The stellate ganglion block with local anesthetics have been widely used to provide pain relief to treat vascular spastic disorders of upper limbs, chronic pain conditions and treatment of refractory angina.

The stellate ganglion block has also been used for increasing radial artery (RA) blood flow and preventing RA spasm by sympathetic blockade in coronary artery bypass surgery.

In our study, two groups will be compared regarding IMA blood flow and diameter. The IMA pulsatility index and diameter will be measured before and after the stellate ganglion block during both the preoperative and intraoperative periods in both groups. Transit-time flowmetry (TTFM) will be used intraoperatively to assess IMA flow. Additionally, topical nitroglycerin will be applied intraoperatively in both groups, regardless of whether they received the stellate ganglion block.

Eligibility Criteria:
Inclusion Criteria:

* Age: 18 to 65 years.
* Patients who will be slated to undergo elective coronary artery bypass graft surgery under Cardiopulmonary bypass in the Department of Cardiothoracic Surgery.

Exclusion Criteria:

* Patient not willing to participate in the study.
* Age more than 65 years.
* Ejection fraction \< 45%.
* History of strokes / Transient ischaemic attacks and vertebro basilar insufficiency
* History of Glaucoma.
* History of allergy to local anaesthetic drugs.
* Emergency coronary artery bypass graft or reoperations.
* Pre-existing contralateral phrenic nerve palsy.
* Patients with existing coagulopathy.
* Allergy to nitroglycerin.
Vector Analysis of Body Composition in Hospitalized Cirrhotic Patients

Patients with acute decompensation of cirrhosis, or acute on chronic liver failure often present with malnutrition, and due to the in-hospital stay, their nutritional intake can vary widely, with several periods of fasting, and sometimes insufficient nutritional support. Therefore patients are prone to develop malnutrition or, the already present malnutrition worsens its status.

Our aim is to evaluate the daily changes in nutritional status in patients with acute decompensation of cirrhosis and evaluate the changes in plasma and serum biomarkers.


Eligibility Criteria:
Inclusion Criteria:

* Age 18-75 years old
* Patients with confirmed cirrhosis.
* Any etiology
* Hospitalized with acute decompensation of cirrhosis
* Signed informed consent

Exclusion Criteria:

* Pregnancy
* Amputation
* Incomplete data
Bone Marrow Autotransplantation in Type 1 Diabetes

This project evaluates the effectiveness of the administration of autologous bone marrow blood in patients with brittle type 1 diabetes mellitus to restore insulin secretion. After mobilization of hematopoietic progenitors (G-CSF) during 3 days, 50 to 90 mL of bone marrow blood will be obtained by multifunction in the posterior iliac crest. The material obtained will be implanted into the pancreas through the magna pancreatic artery after femoral catheterization.


Eligibility Criteria:
Inclusion Criteria:

* diabetes type 1 patients
* 18 to 50 years of age
* more than 5 years of evolution of the disease
* brittle diabetes (HbA1c \> 8.5 % with intensified treatment or severe hypoglycemia episodes

Exclusion Criteria:

* history of cancer
* hematologic alterations
* infectious disease positivity (HIV, HCV etc.)
* diabetic nephropathy
* cardiac failure
* liver disease
* autoimmune systemic disease
* allergy to iodine contrast or anesthesia
Clinician Utilization of Corus CAD (or ASGES) in Primary Care Provider Decision Making

This retrospective study will investigate clinician behavior in diagnosing patients with possible obstructive coronary artery disease who received a Corus CAD (Age/Sex/Gene Expression score - ASGES) result compared to patients who did not have the test performed (matched control patients).

This retrospective study will investigate clinician behavior in diagnosing patients with possible obstructive coronary artery disease who received a Corus CAD (Age/Sex/Gene Expression score - ASGES) result compared to patients who did not have the test performed (matched control patients). The data collected will be from primary care practices and will also assess one to two year health outcomes (MACE, procedure complications). Furthermore, in these real world practice settings, the study will investigate the economic impact of Corus CAD (ASGES) usage at each practice using practice specific data, when available.

Eligibility Criteria:
Inclusion Criteria:

For Corus CAD (Age/Sex/Gene Expression score - ASGES) arm:

* Symptoms suggestive of obstructive CAD, according to the opinion of the site clinician
* Age \>= 21 years
* Resulted Corus CAD (ASGES) test used during the evaluation and/or diagnosis of symptoms suggestive of obstructive coronary artery disease (CAD), preferably 1 year prior to data collection date.

For Control arm:

* Symptoms suggestive of obstructive CAD, according to the opinion of the site clinician
* Eligible for Corus CAD (ASGES) (see exclusion criteria)
* Matched to Corus CAD (ASGES) patients by sex, age +/-2.5 years, and presenting symptoms

Exclusion Criteria:

* History of myocardial infarction (MI) or CAD prior to the index evaluation
* Presentation of high risk unstable angina for the index evaluation
* Concurrent systemic infection or inflammatory process
* Concurrent MI or acute coronary syndrome
* Known diabetes mellitus diagnosis or laboratory test results suggestive of a diagnosis of diabetes mellitus (e.g., HbA1C \>=6.5)
* Use of steroids, immunosuppressive agents, or chemotherapeutic agents, at time of chest pain presentation
Multicenter Bone and Joint Health Study

The purpose of this study is to investigate opportunities for prevention and treatment of knee osteoarthritis (OA) by evaluating potentially modifiable risk factors for disease and poor pain and physical function outcomes especially among those with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.

MOST study participants in the "Existing Cohort" (3,026 subjects) were enrolled in the original study in 2003-2005. Surviving Existing Cohort participants without end-stage knee osteoarthritis will be asked to participate in the 144-, 152-, 160- and 168-month follow-up contacts. In addition, in 2016-2018 the cohort will be enriched by the recruitment of an additional 1,500 "New Cohort" participants with early or mild knee symptoms. The goal of the study is to find novel strategies to prevent disease at an early stage.

Eligibility Criteria:
Inclusion Criteria for "New Cohort" Participants:

* Age 45 to 69 Years (Adult, Senior)
* Males and Females
* Healthy Volunteers
* Community-based Sample

Exclusion Criteria for "New Cohort" Participants:

* Rheumatoid or inflammatory arthritis (based on self-report and use of medications specific to these conditions)
* Serious health condition e.g., end-stage renal disease, etc. that would likely limit follow-up to less than 2-3 years
* Plan to relocate out of geographic region in next 3 years
* Not able to walk without the aid of a person or assistive device
* Knee joint replacement surgery in either knee
* Neither knee fits in the MRI knee coil (determined during Screening Visit).
* Not competent to give informed consent
* Advanced structural tibiofemoral or patellofemoral knee OA disease (KL grade 3 or 4) in either knee (Determined by Knee X-ray Screening)
Picture of Incidental Calcium To Understand Risk Estimate (PICTURE) Trial

This is a prospective randomized controlled trial assessing the impact of notifying patients and their clinicians of an incidental finding of coronary artery calcification (CAC) indicating increased cardiovascular risk. Patients will be identified through completed radiology orders for non-gated, non-contrast chest CT in the appropriate clinical context and then will have an EHR screen for inclusion criteria. The presence of CAC will be confirmed by a board-certified physician. Eligible patients will be randomized to CAC notification or usual care using a 1:1 stratified block randomization method based on baseline statin use.


Eligibility Criteria:
Inclusion Criteria:

* Age 18 and above and \<85
* Non-gated chest CT with CAC
* An encounter after July 1, 2021 with a Stanford-affiliated clinician from one of the following clinics:

  * Stanford Internal Medicine (includes University affiliated clinics)
  * Stanford Family Medicine (includes University affiliated clinics)
  * Non-EP cardiologist

Exclusion Criteria:

* Advanced or poor-prognostic cancer
* No active primary care or cardiology care at Stanford Health Care
* Primary language other than English, Spanish, Vietnamese, Cantonese, or Mandarin
* Baseline statin or non-statin lipid lowering therapy
* Allergy to statin medication or identification of statin-associated muscle symptom
Evaluation of Retinal and Vascular Features in Macular Degeneration After Intravitreal Injections of Bevacizumab

This study evaluates the retinal and vascular features in patients with macular degeneration under the effects of Bevacizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography.

Bevacizumab is a vascular endothelial growth factor antagonist represent an efficacy treatment for exudative age-related macular degeneration acting on vascular hyperpermeability.

The optical coherence tomography and optical coherence tomography angiography represent novel and non-invasive diagnostic techniques that allow a detailed and quantitative analysis of retinal and vascular features.

The study evaluates the changes in optical coherence tomography and optical coherence tomography angiography parameters at baseline and after three monthly injections of Bevacizumab in exudative AMD.

Eligibility Criteria:
Inclusion Criteria:

* age older than 50 years, diagnosis of exudative age-related macular degeneration, treatment-naïve with Bevacizumab for exudative age-related macular degeneration.

Exclusion Criteria:

* age younger than 50 years, diagnosis of exudative macular degeneration due to other causes, previous treatments before Bevacizumab for exudative age-related macular degeneration.
Evaluation of Oral Screen Training With IQoro as Treatment for Dysphagia After Stroke

Purpose The purpose of the study is to evaluate if training with oral screen IQoro® improves swallowing in patients with dysphagia after stroke.

Method Inpatient from a stroke unit in Sweden who have been assessed with fiberoptic endoscopic evaluation of swallowing(FEES) which proves swallowing difficulties (dysphagia) were recruited. The participants were randomise to control- or intervention group. Both groups received usual care. The intervention group were instructed to oral screen (IQoro®) training for 13 weeks. Follow up with FEES was made 13 weeks post of recruitment. The assess with FEES was recorded and the recordings are going to be analyzed afterwards to compare the swallowing ability between baseline and follow up in group and between group.


Eligibility Criteria:
Inclusion Criteria:

* Inpatient at stroke unit at Vrinnevisjukhuset ward 1, due to stroke.
* Patient assessed to have dysphagia (score ≥1 on one of the studied parameters)according to FEES.
* Patient who is able to handle IQoro® according to instructions, independently or with support of assistance from relatives or staff.

Exclusion Criteria:

* Patients with dysphagia of a cause other than stroke.
* Patient with impaired cognitive skill, motor and / or language ability that prevents the possibility of performing training with IQoro®, despite possible support from assistance from relatives or staff.
* Patient who wishes training with the Muppy oral screen® related to saliva leakage.
tDCS and Lower Limb Performance in Stroke

Lower limb rehabilitation is especially important, as the simple act of regaining the ability to walk has subsequent effects on the ability to engage in activities of daily living .So, this study will contribute in describing the management of lower limb motor recovery along with the therapeutic intervention (MRP) with tDCS (anodal stimulation). This study aims to address some of the drawbacks observed in previous studies like allocation concealment, small sample size due to drop outs, short term effects of tDCS and experimental designs as well.

Transcranial Direct Current Stimulation (tDCS) appears to be an intriguing adjuvant for stroke neurorehabilitation, though there are many other methods available. Depending on the polarity used, tDCS alters cortical excitability when electrodes applied over the motor cortex area (M1) to be stimulated, and the cathode above the contralateral eye (Orbital area), tDCS (thus termed anodal) increases cortical excitability. It is easy to use, safe and has minimal side effects like a sensation of itching, post-stimulation headache and sometimes mild nausea may experience. Numerous research indicates that cortical activity rises in conjunction with gait. According to a number of studies, corticospinal neuron activity either parallels or possibly even partially regulates the activity of spinal motor neurons during walking. There exist various techniques for implementing transcranial direct current stimulation in conjunction with multiple supplementary therapies.

Eligibility Criteria:
Inclusion Criteria:

* Stroke for more than 6 months.
* National Institutes of Health Stroke Scale (NIHSS) for severity level (Mild (1-4), Moderate (5-15), Moderate to Severe (16-20), Severe (21-42)

Exclusion Criteria:

* Epilepsy
* Scalp injury/ skin lesion e.g. psoriasis or eczema etc.
* Patient with lower limb amputation or any MSK/neurological disorder that limit the LE function
* Implanted medical devices including intracranial electrodes, surgical clips, shrapnel or a pacemaker
Relationship Between Neck Posture and Stiffness of Head and Neck Muscles, Pain and Proprioception in Desk Workers

In our study, posture in desk workers; it aims to evaluate the relationship between cervical range of motion, proprioception, muscle stiffness, posture and pain.

One hundred twelve participants were included in the study.

Cervical range of motion and cervical proprioception were evaluated with a cervical range of motion (CROM) goniometer device, and muscle stiffness was evaluated with myotonometer device. Pain was evaluated with visual analog scale, and Migraine disability assessment scale (MIDAS) and Neck disability index.

Posture was evaluated with Posture Screen mobile application.

Eligibility Criteria:
Inclusion Criteria:

* Volunteer individuals aged 18-65
* Individuals using a computer in a sitting position at a desk

Exclusion Criteria:

* Individuals who have had serious traumatic injuries to the head, neck and shoulder area
* Individuals who have undergone any surgery on the head, neck and shoulder region
* Individuals with any anomaly in the head, neck and shoulder region
Trial to Assess Vagus Nerve Stimulation Therapy in Children With Lennox-Gastaut Syndrome

The purpose of this study is to evaluate the clinical effectiveness of PINS vagus nerve stimulatior in children with Lennox-Gastaut Syndrome.


Eligibility Criteria:
Inclusion Criteria:

1. Age 3-14 year
2. Lennox - Gastaut syndrome diagnostic standard
3. Regular drug treatment is invalid
4. Antiepileptic drug stability in recent 3 months
5. Good health except epilepsy
6. Patients or his(her) familyscould understand this method and sign the informed consent
7. Patients with good compliance and could complete postoperative follow-up.

Exclusion Criteria:

1. Results of MRI remind epilepsy caused by intracranial space-occupying lesions
2. Had epileptic foci excision surgery or corpus callosum
3. The vagus nerve lesion and damage
4. Tumor, cardiopulmonary anomaly, progressive neurological diseases, asthma， mental disease，peptic ulcer，diabetes Type 1，bad health etc, and other surgical contraindication
5. Participated in other clinical drug test subjects within three months
6. The researchers think that is not suitable for participants'
Clinical Evaluation of Acupuncture Treatment for Negative Symptoms of Schizophrenia

To explore the effects of combined traditional Chinese and Western medicine( Chinese acupuncture combined with Amisulpride Tablets) on negative symptoms, cognitive function and social function in patients with schizophrenia, and the side effects and safety of Chinese acupuncture combined with Amisulpride Tablets.

Our research hypothesis：1. Medically assisted Acupuncture in schizophrenia can improve negative symptoms；2. Drug assisted Acupuncture Therapy has better cognitive function in schizophrenic patients than single drug；3. Schizophrene with acupuncture have fewer and lighter adverse reactions。This study was carried out only in Shanghai Mental Health Center. It was a parallel randomized study.Schizophrene with negative symptoms were treated with atypical antipsychotic drug amisulpride, but still remained negative symptoms. Using the mature Chinese medicine therapy acupuncture auxiliary treatment, using the more reliable clinical evaluation method (the grader blind method: The raters were not sure which patients were the study group or the control group), compared with the single drug treatment, To observe the changes of negative symptoms and cognitive function, and the incidence of adverse reactions of acupuncture therapy, to explore the "new" auxiliary means for the treatment of negative symptoms, to guide clinical individualization and accurate medical treatment.

Eligibility Criteria:
Inclusion Criteria:

* The diagnosis of schizophrenia according to International classification diagnosis-10(ICD-10)
* patients at an age between 18～60 years old of Han nationality

Exclusion Criteria:

* other psychiatric diagnoses
* Suffering from serious physical disease and can not accept the treatment
* Patients to be diagnosed according to ICD-10 for substance abused, development delayed
* Inability to sign informed consent because of capacity due due to severe mental illness, significant psychomotor agitation or slowness test completion
* claustrophobic
* metal implantation in vivo
Ketone Administration During Inactivity and Retraining

The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration. Potential changes in muscle function (cycling performance, knee-extension force and power, jump height) and mass, blood flow and the muscular extracellular matrix will be the main focus. In this context, the dominant leg of the participants (n=24) will be immobilized with a brace for 2 weeks and subsequently retrained in a 4-week progressive resistance exercise training program to stimulate muscle regeneration. During the immobilization and rehabilitation period, participants receive either ketone ester (KE) or placebo (CON). 4 experimental sessions are performed during this time frame in order to evaluate the effects of the trial.


Eligibility Criteria:
Inclusion Criteria:

* Recreational sports participation, including general fitness training, between 2 and 5 hours max per week
* Good health status confirmed by a medical screening
* Body mass index between 18 and 25

Exclusion Criteria:

* Any kind of injury/pathology that is a contra-indication to perform resistance exercise
* Intake of any medication or nutritional supplement that could impact muscle protein synthesis during the period of the study
* Intake of any whey protein, casein or branched-chain amino acid supplement or anti-inflammatory drug from 1 month prior to the start of the study
* Blood donation within 3 months prior to the start of the study
* Smoking
* Pregnant
* More than 3 alcoholic beverages per day
* Current participation in another research trial
* Any other argument to believe that the subject is unlikely to successfully complete the full study protocol
* Adherence to a high-fat, low-carbohydrate ketogenic diet (less than 20% of energy intake derived from carbohydrates)
* (Cow's) milk protein allergy
Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

The purpose of this study is to investigate whether we can improve associative memory performance in healthy subjects, by applying transcranial Direct Current Stimulation (tDCS) during a verbal paired-associate learning task

Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer's disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.

Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether it is possible to improve associative memory using tDCS, the performance in a Verbal Paired-Associate memory task of 4 groups targeting different areas will be compared.

Eligibility Criteria:
Inclusion Criteria:

* Age: 18-35 years
* Native English Speaker

Exclusion Criteria:

* History of severe head injuries, epileptic insults, or heart disease.
* Severe psychiatric disorders and severe untreated medical problems.
* acquainted with the foreign language used in the learning task
* Contraindications for tDCS (pregnant women, implanted devices)