cyrilzakka/clinical-trials huggingface dataset:
The Effects Of DBS Of Subthalamıc Nucleus On Functionality In Patıents With Parkinson's Disease: Short-Term Results

Parkinson's disease is a progressive chronic neurodegenerative disease. In cases where drug treatment is insufficient and drug use is not possible due to drug side effects, highly effective and low-risk surgical treatment options could be used. In Parkinson's Disease; findings such as chest wall rigidity and weakness of the respiratory muscle strength occur. The aim of this study was to determine the effect of preop and postop DBS surgery on respiratory muscle strength, respiratory function and physical performance in patients with Parkinson's disease.

In the study, at least 10 patients with Parkinson's disease who had DBS surgery in Mustafa Kemal University Research and Practice Hospital, Department of Brain and Nerve Surgery will be evaluated. Demographic-physical features, pulmonary functions, respiratory muscle strength, exercise capacity, functionality, and muscle strength will be evaluated

Eligibility Criteria:
Inclusion Criteria:

* Lack of any neurological disease other than Parkinson's
* DBS surgery to be performed in the STN region

Exclusion Criteria:

* Patients with advanced cognitive impairment
* Patients with pulmonary, neurological and orthopedic diseases affecting functionalities
* Pregnancy
* Patients in whom the stimulation was canceled due to infection after surgery.
The Impact of IntegBasic Physical Fitness Rated Neuromuscular Training Intervention on the of Military Personnel

Objective: The study aims to evaluate the efficacy of an 8-week integrated neuromuscular training intervention on the fundamental physical fitness parameters of military personnel, encompassing strength, velocity, agility, and equilibrium.

Methodology: The research randomly allocated 20 military students from the National University of Defense Technology into two cohorts, utilizing an experimental methodology with longitudinal assessments at the onset, midpoint, and conclusion of the intervention to quantitatively assess the influence of the integrated neuromuscular training on velocity and agility. Participants in both the experimental and control groups were evaluated one week prior to the intervention, at the fourth week, and one week post-intervention. Statistical analysis involved a two-factor repeated measures ANOVA to compare measures across the three time points, while paired-sample t-tests were applied for pre-post comparisons. The experimental group engaged in an 8-week integrated neuromuscular training regimen, consisting of three 90-minute sessions per week, culminating in a total of 24 sessions. Concurrently, the control group adhered to a conventional physical training schedule, also structured around three 90-minute sessions per week, over the same 24-session period, thereby ensuring parity in total training duration and frequency between the experimental and control groups.


Eligibility Criteria:
Inclusion Criteria:

* Age between 18-24 years old
* Students with corresponding military status
* Meeting the diagnostic criteria for functional movement screen assessment
* No history of psychological or psychiatric disorders, and not participating in other physical training during the experimental period
* Capable of cooperating to complete the corresponding training and testing, and will not withdraw from the experiment without cause

Exclusion Criteria:

* Major sports injuries within the past 2 years, including fractures, ligament tears, muscle or tendon ruptures, and recurrent dislocations of joints
* Patients with cardiovascular and cerebrovascular diseases and related internal organ conditions
* Failure to pass the functional movement screen test
* Individuals with injuries or discomfort in other areas
Comparison of Programmed Intermittent Epidural Bolus With Continuous Epidural Infusion for Labor Epidural Analgesia

Sixteen million babies were born in 2010, approximately half were by cesarean. Labor analgesia should be the first choice for these parturients based on the consideration of security and humanization. However this labor analgesia rate is quite low in China (\<5%) while in western country, this rate is up to 60%. Programmed intermittent epidural bolus (PIEB) is the latest technique for labor analgesia which has less neurotoxicity theoretically compared with Continuous Epidural Infusion(CEI) with Patient controlled epidural analgesia (PCEA) which is used most commonly. In that study, they reported less total local anesthetic consumption, fewer manual bolus doses and greater patient satisfaction with the PIEB technique. In China, multiple factors contribute to the reasons of low labor analgesia rate. From the patient's point of view, worrying about unsatisfied analgesia, and not adapted to the symptoms of motor block, such as inability to move their legs distressing, both are important reasons of refusing labor analgesia and preferring to cesarean delivery. Therefore, in this clinical trial, we plan to find a safer and more effective regimen for labor analgesia in Chineseparturients. This clinical trial is designed to prove PIEB used Ropivacaine is safer and more effective than CEI for labor analgesia in Chinese parturients.


Eligibility Criteria:
Inclusion Criteria:

* Subjects who agree to join this study
* Age: 22y-40y
* American Society of Anesthesiologists (ASA) physical status 1 or 2
* Gestation : 37-41 weeks
* Primipara
* Singleton fetus and head presentation
* In early labor: cervical dilation for 1-3cm
* Requesting labor epidural analgesia

Exclusion Criteria:

* Contraindication for epidural analgesia
* Height less than 150 cm or more than 170 cm
* Morbid obesity (BMI more than 35)
* High-risk pregnancy:(gestational diabetes mellitus, gestational hypertension, placenta previa, placental abruption, preeclampsia)
* Received parenteral opioids
* Unable to perform motor block evaluation tests
Efficacy of a Web-based Weight Loss Program

Since overweight and obesity, a risk factor for various diseases, is a prevalent problem in the modern society, it is important to search for new strategies to counteract this. In contrast to in person support, the internet provides a low cost opportunity, which is able to reach a large part of the population. Therefore a web-based weight loss program may be an adequate mean for many people. Now it is hypothesised that a web-based weight loss program is able to support a reduction of body weight and weight-related cardiovascular risk factors effectively and to promote a healthier lifestyle. It is expected that program use, compared to a control group, results in greater reductions in body weight and cardiovascular risk.


Eligibility Criteria:
Inclusion Criteria:

* age 30-65 years
* body Mass Index: 27-39,9 kg/m2
* ECOG-Performance status degree 0 or 1
* basal internet skills
* private internet access
* signed informed consent

Exclusion Criteria:

* malign diseases
* major organ diseases
* inflammatory bowel diseases
* insulin - dependent diabetes mellitus
* pregnancy, breast feeding
* treatment of eating disorders (e.g. bulimia, anorexia nervosa) within past 5 years
* parallel participation in other weight loss programs or other trials
* weight loss \> 5% within past 6 month
* chronic therapy with glucocorticoids
* subjects treated because of psychiatric disorders (e.g. schizophrenia, bipolar disorder) in the past
* subjects with expected non-compliance to protocol guidelines
Erythrocyte Ghost Mediated Retinal Diagnosis

Instead of the usual procedure of injecting ICG dye directly into an arm vein, now the dye can be placed inside of RBCs. When a small volume of the RBC's with the dye is injected into a person's arm, the individual RBCs can be seen as they flow through the retinal blood vessels.

Capillary erythrocyte movement throughout the entire human macula can be observed routinely for periods up to 20 minutes by autologous re-injection of a small volume (about 1 mL) of indocyanine green (ICG)-loaded erythrocytes, making possible for the first time quantification of blood flow in individual capillaries, including abnormal structures like choroidal neovascularization (CNV), and it makes possible characterization of vasomotion in ocular vasculatures.

Eligibility Criteria:
Inclusion Criteria:

1. A male or female, of any race who is at least 40 years of age and has clinical signs of CNV or exudative manifestations of AMD, has clinical signs of DR, or clinical signs of retinal occlusive disease.
2. Patients with subfoveal, extrafoveal or juxtafoveal CNV, which is classic, minimally classic or occult and has dimensions less than 25.0 mm2 as measured on the sodium fluorescein angiogram (SFA).
3. Patient with recurrent CNV, where previous treatment never involved the foveal avascular zone (FAZ).
4. Analysis of highspeed ICGA must show one or more welldefined feeder vessel.
5. Patient must have best corrected visual acuity based on the ETDRS chart between 20/40 and 20/320 in the study eye.
6. Patient must be willing, be able to comply with the protocol and provide informed consent.

Exclusion Criteria:

1. CNV secondary to any cause other than AMD or DR.
2. Patient with significantly compromised visual acuity in the study eye due to concomitant ocular conditions.
3. Patient participating in any other investigational drug study.
4. Patient with significant liver disease or uremia.
5. Patient with known adverse reaction to indocyanine green or iodine.
6. Patient is pregnant or nursing.
Blood Pressure Measurement Methods and Prediction of Intracranial Hemorrhage After Thrombectomy in Stroke

A monocentric, non-randomized, prospective study in which each patient is his/her own control.

The study investigates 2 methods of blood pressure measurement, within the first 24 hours after reperfusion, i) Continuous measurement of blood pressure with the Clearsight device (Edwards) and ii) intermittent blood pressure measurements with cuff.

Patients will be followed for 72 hours:

* inclusion after reperfusion: clinical evaluation with NIHSS (National Institute of Health Stroke Score) score, measurement of blood pressure.
* within 24 hours after reperfusion: blood pressure measurements
* at 24 hours: NIHSS score.
* Between 24 and 36 hours :cerebral scan (assessment of hemorrhagic transformations and cerebral infarction volumes).
* 72 hours after reperfusion: brain scanner in case of hyperdensity on the initial scanner

Eligibility Criteria:
Inclusion Criteria:

* Occlusion of internal carotid arteries or proximal middle cerebral arteries (segment M1).
* Reperfusion after a thrombectomy procedure (defined by a 2b-3 Thrombolysis In Cerebral Infarction (TICI) score).

Exclusion Criteria:

* Per-procedure hemorrhagic complications (prior to reperfusion)
* Known pregnancy
Learning Curves for Airtraq Versus King Vision Laryngoscopes

Several videolaryngoscopes have been developed but few have been compared in terms of their learning curves and efficacy. The aim of this study is to compare the learning curves of Airtraq versus King Vision in a group of residents trained in direct laryngoscopy. Four residents will perform, after a short training in manikin, 8 intubations with each device. The sequence of use of the devices will be randomized. Outcome measures will be duration of intubation attempt, glottic visualization and percentage of intubation success.


Eligibility Criteria:
Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status classification I-II.
* Elective surgery.
* General anesthesia required.

Exclusion Criteria:

* Bronchoaspiration risk.
* Pharmacological allergies.
* Craniofacial anomalies.
* Body mass index \> 30.
* Prior history of airway management complications.
* Presence of clinical signs predictive of difficult intubation.
The Role of Postoperative Antibiotics in Laparoscopic Cholecystectomy

Comparison between postoperative parenteral prophylactic antibiotics, and oral antibiotics regarding the incidence of post laparoscopic cholecystectomy infection.


Eligibility Criteria:
Inclusion Criteria:

* Adult patients (aged above 18 years) undergoing laparoscopic cholecystectomy.

Exclusion Criteria:

* patients with comorbidities (Diabetes, malignancies, Immunosuppressed). Lost of follow-up. Patients received antibiotics within 72 hr before admission. Complicated cases involved, gangrenous and perforated cholecystitis and abscess.
Bone Structure in Patients with Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography

The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone deficiency.


Eligibility Criteria:
Inclusion Criteria:

* Men and women diagnosed with Adult onset Growth Hormone Deficiency
* Age between 18-80
* Informed consent

Exclusion Criteria:

* Competing bone disease (e.g.. Mb. Paget, myelomatosis, osteogenesis imperfecta, osteoporosis, primary hyperparathyroidism)
* Ongoing medical treatment affecting bone metabolism (eg. osteoporosis medications)
* Ongoing pregnancy or breast feeding
Clinical Value of Self-assessment Risk of Osteoporosis in Chinese

This cross-sectional study aimed to validate the effectiveness of the combined use of the Osteoporosis Self-Assessment Tool for Asians (OSTA) and the One-Minute Osteoporosis Risk Test (IOF test) in a population from Wuhan, China.

This cross-sectional study was a field investigation. A total of 400 Wuhan residents who visited the Health Examination Department at our hospital were invited to participate in this study. Potential participants were informed of the aim and procedures and were asked to sign an informed consent form before participation. Inclusion criteria were as follows: age of at least 20 years, able to read and fill out the questionnaire, and willingness to participate. Exclusion criteria were as follows: severe liver, heart, or kidney impairment, and tumor. Procedures of the study were in accordance with the Declaration of Helsinki and were approved by the local ethics committee.

The study population was divided into four groups according to age and sex: Younger Women (age ≤ 55 years), Younger Men (age ≤ 55 years), Older Women (age \> 55 years), and Older Men (age \> 55 years). A research assistant and a nurse distributed the Chinese version of the IOF test to participants. The Chinese version of the IOF test includes 10 questions, two of which are specific to women and one to men. The maximum number of risk factors is 8 for women and 9 for men. Individuals were regarded as susceptible to osteoporosis risk if they answered "yes" to any of the 10 questions.

To assess the grade of osteoporosis risk, the OSTA index was calculated by the equation (body weight (kg) - age (years))\*0.2. An OSTA index of -1 to -4 is regarded as medium risk, greater than -1 as low risk, and less than -4 as high risk.

Eligibility Criteria:
Inclusion Criteria:

* age of at least 20 years, able to read and fill out the questionnaire, and willingness to participate.

Exclusion Criteria:

* severe liver, heart, or kidney impairment, and tumor. Procedures of the study were in accordance with the Declaration of Helsinki and were approved by the local ethics committee.
Substrate Metabolism, Growth Hormone Signaling, and Insulin Sensitivity During Fasting

Background: Calorie restriction increases longevity in many species and attenuate the development of chronic disorders including type 2 diabetes, cardiovascular diseases and cancer. In mice reduced activity of insulin-like growth factor I (IGF-I) and/or insulin is associated with extended longevity. Growth hormone (GH) is the main regulator of IGF-I production, but the molecular mechanism whereby GH switches from IGF-I stimulation (protein anabolism) to fatty acid oxidation (fatty acid catabolism) as well as induction of insulin resistance during fasting remains enigmatic.

Hypotheses: The changes of the global set of metabolites, induction of insulin resistance, and the shift in metabolism from protein anabolism to lipolysis together with the potentially favorable effect of calorie restriction during fasting depend on preserved fasting-induced GH secretion.

Aim: The investigators wish to provide knowledge on changes in metabolites and shift in signaling pathways that take place at the transition to the fasting state among healthy overweight and obese subjects. Furthermore the investigators wish to determine the effect of GH on the adaption of the metabolism to a fasting state.


Eligibility Criteria:
Inclusion Criteria:

* healthy men
* written consent
* body mass index (BMI) 25-40
* age 20-60 years

Exclusion Criteria:

* any kind of disease
* regular medication
Cerebral Microembolism During Hemodialysis

There is increasing evidence that renal replacement therapy (= continuous veno-venous hemodialysis) generates cerebral microembolism which is detectable on transcranial Doppler ultrasound.

The aim of this study is to monitor patients with transcranial Doppler under two conditions: during hemodialysis and in a hemodialysis-free interval (in each period cerebral embolic load is detected during 30 minutes).

The study hypothesis is that during hemodialysis the cerebral embolic load is significantly higher than in the hemodialysis-free interval.


Eligibility Criteria:
Inclusion Criteria:

* Renal replacement therapy (continuous veno-venous hemodilalysis) on the in-house intensive care unit
* Age \> 18yrs and \< 90yrs

Exclusion Criteria:

* Absent informed consent
* Preexistent neurological morbidity
* Neurocognitive disturbances
* Carotid artery stenosis \> 70%
* Patent foramen ovale
* Treatment with other extracorporeal devices
* Cardial pathology (valvular heart disease, prosthesis, endocarditis)
* Pregnancy, drug abuse
* Inclusion in an other clinical study
* Allergy against materials of the medical device used in the study (transcranial Doppler) or temporal skin/bone lesions
Prospective Validation of the CoDE-HF Algorithm for the Diagnosis of Acute Heart Failure

Acute heart failure is a life-threatening condition where the heart is suddenly unable to pump blood around the body. It can be challenging to diagnose because the symptoms often mimic other conditions. Previous studies have showed that delays in making the correct diagnosis result in worse outcomes. We therefore developed a decision-support tool called CoDE-HF that uses a computer algorithm to combine levels of a blood test called NT-proBNP with patient factors to calculate the probability of acute heart failure for an individual.

In this project, we wish to evaluate the performance of CoDE-HF in approximately 2,000 patients attending the Emergency Department with suspected acute heart failure. We will store surplus material from their blood tests to measure NT-proBNP and link information from their electronic health records with other routinely collected medical information in regional and national databases in order to evaluate this algorithm.


Eligibility Criteria:
Inclusion Criteria:

* Patients presenting to the Emergency Department with acute breathlessness
A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus Treated With a Stable Dose of Metformin

This study will evaluate the efficacy, safety, tolerability, and pharmacokinetics of GK Activator (2) in combination with metformin, compared to that of placebo (metformin monotherapy), in patients with type 2 diabetes mellitus. Patients will continue on their stable dose of metformin and will be randomized to receive either GK Activator (2) or placebo. The anticipated time on study treatment is less than 3 months, and the target sample size is 100-500 individuals.


Eligibility Criteria:
Inclusion Criteria:

* adult patients 30-75 years of age;
* type 2 diabetes mellitus;
* individual maximal tolerated daily dose of metformin monotherapy for \>=3 months prior to screening.

Exclusion Criteria:

* type 1 diabetes mellitus;
* any oral anti-hyperglycemic medication, other than metformin monotherapy, during last 3 months
Embryo Implantation After Induced Endometrial Injury

Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.

The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF

Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown.

We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques.

For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.

Eligibility Criteria:
Inclusion Criteria:

* 19-44 aged women
* 19-29.9 Kg/m2.
* 1st or 2nd fresh embryo transfer ( egg donation).
* 1 or 2 blastocysts available.
* written agreement.
* \> or = 6 mms endometrial thickness.

Exclusion Criteria:

* Premature ovarian failure.
* Endometrial pathology.
* Insufficient endometrial development.
* Hydrosalpinx
* Mullerian malformations.
Effect of a Carbohydrate-rich Diet in Healthy Subjects

The present research protocol will analyze whether a short-term modification (one week) of dietary habits would have an impact on the postprandial metabolism of dietary fatty acids and on their uptake by non-adipose tissues, in healthy subjects.

Each subject will participate in two protocols randomly determined and separated by a period of one month: a 7-day isocaloric diet (Protocol A) and a 7-day carbohydrate-rich diet containing +50% of the subject's energy needs. (Protocol B).

At the end of each diet, the subject will go through a postprandial metabolic study of 8 hours where different parameters will be measured thanks to PET imaging and perfusions of stables isotopes.


Eligibility Criteria:
Inclusion Criteria:

Healthy subjects: subjects with normal glucose tolerance determined according to an oral glucose tolerance test and with a BMI above 25 kg/m2 without first degree of familial history of type 2 diabetes (parents, siblings).

Exclusion Criteria:

* overt cardiovascular disease as assessed by medical history, physical exam, and abnormal ECG
* treatment with a fibrate, thiazolidinedione, beta-blocker or other drug known to affect lipid or carbohydrate metabolism (except statins, metformin, and other antihypertensive agents that can be safely interrupted)
* presence of liver or renal disease, uncontrolled thyroid disorder, previous pancreatitis, bleeding disorder, or other major illness
* smoking (\>1 cigarette/day) and/or consumption of \>2 alcoholic beverages per day
* prior history or current fasting plasma cholesterol level \> 7 mmol/l or fasting TG \> 5 mmol/l
* any other contraindication to temporarily interrupt current meds for lipids or hypertension
* being pregnant
* not be barren