cyrilzakka/clinical-trials huggingface dataset:
Long-pulsed 1064 nm Nd-YAG Laser Versus TCA 20% in Treatment of Keratosis Pilaris

Keratosis pilaris (KP) is a common disorder of keratinization. There are different treatment modalities for KP with variable results. Nd:YAG laser and chemical peels are among these treatment modalities, however, there is no enough evidence in the literature regarding their efficacy. The aim of this study is to assess and compare the efficacy of long pulsed Nd:YAG laser and trichloreacetic acid 20% in treatment of keratosis pilaris.

Keratosis pilaris (KP) is a genetic disorder of keratinization of hair follicles of skin. It's a very common benign condition that manifests as small, rough folliculocentric keratotic papules, often described as chicken bumps, chicken skin or goose-bumps, in characteristic areas of body, particularly the outer upper arms and thighs.

Trichloreacetic acid (TCA) is a type of chemical peels that is derived from acetic acid by the chlorination of 3 hydrogen ions. It can induce coagulative necrosis of proteins and cells. The depth of action depends on various factors e.g the number of layers applied and its combination with substances that potentiate its action.

Nd: YAG laser is a type of hair removing devices that operates at wave length of 1064nm. This wave length allows for less absorption at the epidermis. It is less absorbed by melanin, which leads to lower side effect and better tolerance but less efficacy in dark skinned patients.

Eligibility Criteria:
Inclusion Criteria:

* Patients above 18 years with KP.
* Patients with KP affecting back of the trunk, arms, thighs, forearms, legs and buttocks.

Exclusion Criteria:

* Pregnant or lactating females.
* Patients who had performed any laser treatment for KP within 6 months prior to the study.
* Patients with history of oral retinoids within 3 months prior to the study.
* Patients with history of hypertrophic scars or keloids.
* Patients who used any topical treatment one month prior to the session.
* Patients with acne affecting the same sites of keratosis pilaris.
* Patients with active skin diseases affecting the area involved with KP e.g. folliculitis and eczema.
Post-lobectomy Use of Glucose for Pleurodesis and Air-leak Cessation. A Feasibility Trial.

It is common practice to leave a chest drainage catheter after lung surgical resections to manage air leaks. The air leakage will usually stop in the initial postoperative days, but in a few patients, it will last for a longer period of time, preventing the removal of the chest tube that can lead to patient discomfort, increased likelihood to develop postoperative complications and longer length of hospital stay. Pleurodesis is an effective method to address postoperative air leak which consists in injecting an irritating solution into the chest cavity. This is not performed regularly after lung resections for different reasons including associated pain, costs, and fear of infections. Pleurodesis with hyperosmolar glucose solution have been used for years with good results in some Asian countries because of its simplicity and low cost. Its effectiveness for pleurodesis has been reported in cases of spontaneous pneumothorax and chylothorax, but its efficiency to stop air leaks in the postoperative period remains to be defined.


Eligibility Criteria:
Inclusion Criteria:

* Patients aged 18 years or older at the time of surgery
* Having undergone a simple lung lobectomy for malignancy, primary or metastatic
* Procedure performed through thoracotomy, sternotomy or video-assisted thoracic surgery (VATS), and associated or not to mediastinoscopy, staging thoracoscopy, mediastinal lymph nodes sampling or mediastinal lymph nodes dissection
* Normally recovery after a surgery performed between 12 and 24 hours earlier

Exclusion Criteria:

* High amount of liquid drainage from chest tube (\>500 cc in the last 8 hours)
* Minimal air leak (\<20 cc/min in one of the last 4 hours)
* Large air leak (\>500 cc/min in one of the last 4 hours)
* History of previous ipsilateral thoracotomy, lung resection, rib fracture, chest trauma, or lung/thoracic infection
* Diabetes or hyperglycemia
* Immunity disorders
* Allergy to local anaesthetics
* Hemodynamic instability
* Need for respiratory support
* Inability to give informed consent
Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia

This study will examine the physical response to clozapine or chlorpromazine in people with schizophrenia that has not improved with treatment.

This is a longitudinal double-blind 12-week study of the clinical and biochemical response to clozapine or chlorpromazine in a group of treatment-refractory schizophrenic patients.

The study has 4 phases: (1) A recruitment period; (2) a period of discontinuation of psychotropic medication; (3) a drug-washout period; and (4) a 12-week double-blind trial of clozapine or chlorpromazine.

Eligibility Criteria:
Inclusion Criteria:

* 19-60 years of age
* Diagnosis of schizophrenia
* BPRS score \> 50
* Clinical Global Impressions rating \> 4
* One of the following: BPRS items rated greater than or equal to 4, conceptual disorganization, suspiciousness, hallucinations, unusual thought content.
* At least 2 six-week trials of different neuroleptics given at a dosage equivalent to at least 600 mg per day of chlorpromazine OR at least 1 eight-week trial of a neuroleptic given at a dosage equivalent to at least 800 mg per day of chlorpromazine.
* The patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent.

Exclusion Criteria:

* History of substance dependence within the past 2 months
* Major medical problems precluding the use of clozapine
* Pregnancy or lactation
* A serious suicide/homicide risk
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

The goal of this exploratory, mixed-method design study is to gather qualitative and quantitative data obtained through interviews and questionnaires with veterans who are currently enrolled at the VA for healthcare. The main question this study aims to answer is: How do veterans diagnosed with PTSD and enrolled for care at the VA understand MDMA-assisted therapy for PTSD? Using a story-completion approach, participants will be provided with a brief story starter involving a fictitious character and scenario and asking them to complete the story. Few contextual details will be offered about the character. In responding to ambiguous cues, participants are thought to project their conscious and subconscious perceptions about the phenomenon in question onto the story, a useful method for exploring stigmatized topics. The purpose of this exercise is to ascertain the participants attitudes and perceptions regarding MDMA-Assisted Therapy.

Veterans will be informed of the study by their VA providers (Behavioral Health Clinic, PCMHI, PTSD Clinic, CDRP, Primary Care). Veterans who are interested will have their contact information passed on to the study investigators. Once screened and enrolled in the study veterans will complete a brief demographics form, and three brief symptom screening questionnaires: PTSD Checklist for DSM-5, 5-Item screener for PTSD, and Patient Health Questionnaire 9. Participants then engage in the recorded interview during which they are provided with a brief story starter, as described above. In the story, a fictitious veteran with a diagnosis of PTSD is offered an opportunity to enroll in a clinical trial and receive MDMA-Assisted therapy. Participants are asked to share what questions, concerns, hopes, and expectations may be present for the fictitious veteran in the story. Interviews will then be transcribed and the PI and the collaborators will read all transcriptions and generate recurring themes that can be reliably coded. The investigators will then code the transcripts for the presence of themes. Data analytic plans include calculating the prevalence of each theme and examining their correlates with measures of severity of symptoms as well as any demographic variables. It is hoped that this data can inform educational and other roll-out efforts within the VA system as MDMA-Assisted therapy approaches FDA approval as a treatment for PTSD.

Eligibility Criteria:
Inclusion Criteria:

* Veterans enrolled in VA care
* Active diagnosis of PTSD, as determined by the referring provider or confirmed by medical records.
* Age 18 or older
* Fluent in written and spoken English

Exclusion Criteria:

* Cognitively impaired to the extent that patient cannot comprehend the survey
* Has already completed the interview
Fasting Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mg

The objective of this study was to investigate the bioequivalence of Mylan's valacyclovir hydrochloride 1000 mg tablets to GlaxoSmithKline's Valtrex® 1000 mg tablets following a single, oral 1000 mg (1 x 1000 mg) dose administered under fasting conditions.


Eligibility Criteria:
Inclusion Criteria:

* healthy, adult subjects, 18 years and older
* able to swallow medication

Exclusion Criteria:

* institutionalized subjects
* history of any significant disease
* use of any prescription or OTC medications within 14 days of start of study
* received any investigational products within 30 days prior to start of study
Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer

This study is an observational study of blood and tissue biomarkers. Investigators plan to evaluate the accuracy of lung cancer biomarkers found in the blood in determining if a lung nodule is cancer or benign. Investigators also plan to examine another biomarker found in the tumor tissue to identify participants after lung cancer surgery who have a high risk for recurrent cancer. Finally, investigators plan to determine if one of the blood-based biomarkers can be used to detect any late cancer recurrence.


Eligibility Criteria:
Inclusion Criteria:

* Potentially-resectable lung nodule 8-40 mm diameter suspected (no preop diagnosis) of being a clinically node-negative lung cancer \[clinical stage IA-IB (cT1a-T2aN0), \<4cm diameter\].
* If surgical resection is recommended, patient will undergo surgery at Moffitt Cancer Center.
* If a definite tissue diagnosis is obtained and stereotactic body radiotherapy (SBRT) is the recommended treatment instead of surgery, the SBRT will be delivered at Moffitt Cancer Center.
* \>18 years old, male or female.
* ECOG performance status 0-1.
* Agree to participate in the follow-up protocol.
* Any suspected primary lung cancer cell type (except a suspected typical carcinoid tumor, carcinoma in situ or minimally-invasive carcinoma).
* Ability to understand and the willingness to sign a written, informed consent document.

Exclusion Criteria:

* Participants who are actively receiving any cancer treatment.
* Participants with uncontrolled intercurrent illness.
* Prior lung cancer within 5 years.
* Current active other major cancer except non-melanoma skin cancer.
* Patients with pure ground glass opacities (nodules) or hilar masses.
* Suspected typical carcinoid cell type (well-differentiated neuroendocrine carcinoma).
* Metastatic nodule (suspected) in the lung from an extrapulmonary cancer.
* Patient unable to provide informed consent.
* Prisoner or incarcerated individual.
* For surgical patients, a R1 or R2 resection.
Effect of Addition of Pyramidal Exercise to Intermittent Fasting on Dryness of Eye in Pre-diabetic Psoriasis Patients

insulin resistant psoriatic obese patients may complain problems of dryness of eye. Intermittent fasting may improve dryness of eye, obesity, insulin resistance, and psoriasis. Exercise, as applied in pyramidal form, if added to intermittent fasting may improve effect of intermittent fasting.

forty obese patients with dryness of eye, obesity, insulin resistance (prediabetes), and psoriasis (chronic plaque) will randomly distributed to group I (n =20 patients) or group II (n=20). Both groups will receive The intermittent fasting regimen consisted of eating ad libitum for five days and then will restrict calories ('fasting') for two days per week, for a duration of 12 weeks. On the fasting days, participants will be instructed to restrict their calories to a maximum of 600 kcal/day for females and 650 kcal/day for males.

The intermittent fasting intervention will consist of a dietary intervention based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window of 6 hours or less from 8:00 am till 2:00 pm, twice per week on 2 non-consecutive days.

Group I will receive a pyramidal training will be adopted for nearly 60 minutes (nearly two rounds of 21 minutes of running on electronic treadmill will be separated with 10 minutes of rest between the two rounds. Also, warming (4 minutes before start of pyrimidal trianing) and cooling (4 minutes after pyramidal training) will be done through gentle stretching exercises/activities. the exercise will be applied 3 times weekly for 2 weeks

Eligibility Criteria:
Inclusion Criteria:

* chronic plaque psoriasis
* obesity class I
* prediabetic persons
* dryness of both eyes

Exclusion Criteria:

* cardiac insults
* respiratory insults
* diabetics hypertensives or renal, hepatic insults
Coronary and Cerebral Perfusion Optimization in Cardiac Arrest: A Feasibility and Physiological Study

Our general objective, during this study, is to evaluate the feasibility and potential physiological benefits of using REBOA (resuscitative endovascular balloon occlusion of the aorta) CPR (cardiopulmonary resuscitation) for patients presenting with a cardiac arrest to a community hospital. This would represent the first step for doing a larger, randomized clinical trial on the use of REBOA in non-traumatic cardiac arrest.

Primary objective: Validate the feasibility of using REBOA in a community hospital setting during cardiac arrest as an adjunct to ACLS (advances cardiac life support) . This will be done by measuring time to REBOA placement and successful inflation. Furthermore, we will also document any REBOA related complications.

Secondary objectives: Evaluate the potential physiological benefits of REBOA for human subjects in NTCA (non traumatic cardiac arrest) that are not responding to standard ACLS.

Study Design and Methodology Trial design The trial is a single-center, single-arm, open (unblinded), feasibility, experimental study.

Study Duration The study is expected to begin in winter 2022 and last approximately 12 months. Population studied The population studied will be patients in non-traumatic cardiac arrest at Santa Cabrini Hospital, aged 18-75 years old.

Patients presenting with a witnessed cardiac arrest (out of hospital cardiac arrest (OHCA) or in hospital cardiac arrest (IHCA)) and in which ACLS was performed for at least 15 minutes or BLS for at least 30 minutes and for no more than 60 minutes will be evaluated for eligibility to participate in the study.

Number of patients 20

Eligibility Criteria:
Inclusion Criteria:

* - Patients aged 18-75 years old
* Suspected reversible cause of cardiac arrest (except for trauma), with one of any of the following prognostic signs30

  * Reactive pupils
  * Agonal breathing
  * EtCO2\>10 mmHg
  * Any cardiac activity on bedside echocardiogram
* Body habitus accommodating automated Lund University Cardiac Arrest System (LUCAS)
* Level of care includes CPR, or unable to obtain level of care (if possible, validate with relative)
* More than 15 minutes of ACLS with no ROSC or more than 30 minutes of BLS with no ROSC

Exclusion Criteria:

* Transfer accepted for ECPR

  * History of severe dementia
  * Advance Medical Directives against resuscitation
  * History of aortic pathology or surgery
  * LUCAS not compatible with the patient's body habitus
  * Pregnancy
  * Any illness resulting in loss of independent living capacity
  * Severe cardiopulmonary disease
  * Aortic dissection, aortic aneurysm, tension pneumothorax or tamponade seen on TEE/TTE
  * Strangulation
  * Suspected intracerebral hemorrhage
  * Accidental hypothermia
  * More than 60 minutes of resuscitation
Accuracy of Dental Contacts of an Occlusal Splint Made According to Conventional or Digital Techniques Using GeoMagic®.

To compare the accuracy of the occlusal splints made by conventional impression and milled with the splint made by intraoral scanner and milled.

Forty participants received two different occlusal devices from two different workflows (fully conventional and fully digital). Every splint was scanned before and after the occlusal adjustments in order to compare the volumetric changes. Furthermore, the scans were compared in a software Geomagic® Control X calculates and measures the distance from every surface point from the initial dataset (occlusal devices before adjustment) to the final dataset (occlusal device after adjustment).

Eligibility Criteria:
Inclusion Criteria:

* Patients between 18 to 70 years old.
* Patients who maintain until first molar in both arches.
* Patients who need occlusal splints due to bruxism.

Exclusion Criteria:

* Pregnant patients.
* Patients with removable prostheses.
* Patients with fixed prostheses between six to six in both arches.
* Patients with partial edentulism, do not maintain until first molar in both arches.
* Patients with Temporomandibular Disorders (TMD): articular noises, pain on palpation, limited opening.
A Phase 2/3 Multicenter, Controlled Trial Of rhBMP-2/CPM In Tibial Fractures

The primary objective of this study is to assess whether a single dose of rhBMP-2/CPM administered at the fracture site via percutaneous injection, in combination with standard of care, accelerates fracture union and return to normal function in subjects who have a closed diaphyseal tibial fracture when compared to standard of care alone.


Eligibility Criteria:
Inclusion Criteria:

* Skeletally mature, male and female subjects who are at least 18 years old.
* Closed diaphyseal tibial fracture.
* Closed reduction and definitive internal fixation by means of a reamed, locked intramedullary nail within 72 hours after injury.

Exclusion Criteria:

* Concurrent fractures of the ipsilateral or contralateral lower extremity other than the ipsilateral fibula, that would impede performance on the functional assessment of weight bearing.
* Planned procedure(s) to stimulate fracture healing after intramedullary nailing.
* Neurovascular impairment of the fractured limb, deep vein thrombosis, or (impending) compartment syndrome.
Enhancing Oral Cancer Awareness Among Minorities

To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention

The study evaluates the difference in outcome of two distinct interventions aimed at enhancing oral cancer awareness and prevention among participants from African American communities in the Richmond area. Participants assigned to the first intervention arm will receive traditional educational handouts sourced from trustworthy and reliable health sources such as the CDC, American Cancer Association (ACA), and other health education resources. These handouts will be provided to the participants and provided enough time to read them based on calculated reading time, focusing on increasing awareness of oral cancer risks, preventive strategies, and the importance of regular dental check-ups. Participants assigned to the second intervention arm will engage with an AI-powered chatbot designed specifically for oral cancer education. The chatbot interaction will be initiated through a provided link, allowing participants to access information and ask questions related to oral health and cancer prevention. The chatbot is programmed to provide accurate information on oral cancer risks, symptoms, preventive measures, and the importance of regular dental check-ups

Eligibility Criteria:
Inclusion Criteria:

* Identify as African American as defined by the US Census
* Participants must be able to read, speak, and write in English

Exclusion Criteria:

* Individuals who cannot physically or mentally participate in the research project will be excluded
* Adults unable to consent
* Individuals who are not yet adults (infants, children, teenagers)
* Prisoners
Project IMPACT Immunizations (IMProving America's Communities Together) Scaled Demonstration

The primary objective of this study is to evaluate how implementing an innovative care model that provides the pharmacist access to a patient's vaccine history at the point-of-care impacts the pharmacist's ability to identify unmet vaccination needs and increase vaccination rates for routinely recommended adult vaccinations.

This multi-site study will use a pre-post design with a population-based comparison group to investigate the impact of implementing an innovative care model on the pharmacist's ability to identify unmet vaccination needs and increase vaccination rates for routinely recommended adult vaccinations. The innovative care model enables the pharmacist to utilize a bi-directional IIS to assess patients' vaccination histories, identify unmet vaccination needs, and document the care provided. The project duration has been established to allow sufficient time for each pharmacy to implement the innovative care model and monitor each pharmacy for a 6-month study period. The American Pharmacists Association (APhA) Foundation has an a priori intent to publish the project results.

Eligibility Criteria:
Inclusion Criteria:

* Individuals eligible to be enrolled in the study include any person at least 18 years of age who is eligible for a comprehensive vaccination history review as determined by the pharmacist.

Exclusion Criteria:

* n/a
Evaluation of Passive Stretching in the Hamstrings Flexibility

The present study aimed to analyze the influence of passive stretching before and after strength training on flexibility of the hamstrings in people who work out

Question: Does passive stretching before and after strength training effect the flexibility of the hamstrings in people who work out?

Design: Intervention study in humans

Participants: 40 healthy student volunteers, ranging in age from 18 to 35 years old, who work out.

Intervention: The Wells bench was used to assess the flexibility of the hamstring muscle. In this test, a person sits on a mat, with the soles of both feet maintaining contact with a box. The top of the box has an indicator marked in centimeters that is used to measure flexibility by how far the person can push the indicator without bending the legs. The knees of the seated person are extended while the hips are flexed. The subject is then asked to take a deep breath, and during exhalation, flex the trunk forward with the upper limbs extended.

The upper limbs are supported by a bench of 23 cm long aligned with a tape measure over the bench. During flexion of the trunk, the right hand is placed over the left and the tips of the fingers touch the indicator on top, and move it forward as far as possible.

Eligibility Criteria:
Inclusion Criteria:

* The healthy students volunteers who worked out at the gym between 1-15 months of activities and ranging in age from 18 to 35 years

Exclusion Criteria:

* Volunteers who had history of chronic disease diagnosed and /or musculoskeletal injury.