cyrilzakka/clinical-trials huggingface dataset:
Cognitive Dysfunction in Parkinson's Disease

This study plans to learn more about the brain function related to thinking problems in individuals with Parkinson's disease.

Dementia is the leading cause of nursing home placement in Parkinson's disease (PD) yet little is known about the cause(s) of cognitive dysfunction in PD and there are no effective treatments. The investigators preliminary data and other published studies suggest that abnormalities in brain activity involving networks important for normal thinking and memory may contribute to cognitive dysfunction in PD and may represent a target for treatment. This proposal will identify abnormalities in cortical activity related to cognitive dysfunction in PD using magnetoencephalography and will perform a randomized control trial of bifrontal repetitive transcranial magnetic stimulation to determine the therapeutic potential of modulating this brain activity.

Eligibility Criteria:
Inclusion Criteria:

* Diagnosis of probable PD (using United Kingdom Brain Bank criteria)
* Diagnosis of mild cognitive impairment
* No unstable medical condition

Exclusion Criteria:

* Features suggestive of other causes of Parkinsonism or other neurological disorders
* Prior deep brain stimulation (DBS) or ablation surgery
* Evidence for active depression or Hospital Anxiety and Depression Scale (HADS) score greater than or equal to 11
* Motor symptoms expected to interfere with scanning (e.g. sever tremor)
* Contraindications to TMS, MEG, or MRI such as pregnancy, pacemaker, unstable cardiac disease, skull lesion, claustrophobia, history of epilepsy, or on medications known to lower seizure threshold
* Implanted electronic devices or metal
Influence of Socio-Economic Factor on Net Survival in Patients With Multiple Sclerosis in France ( ECOVIMUS).

Background: In comparison to general population, persons with Multiple Sclerosis have a higher risk to premature death with an estimate reduced life expectancy from 7 to 14 years. However, risk factors of mortality in MS are not well identified and well known. Following the example of studies carry on cancers survival, socioeconomic status (SES) may have an influence on survival in MS.

Objective: The main objective of ECOVIMUS is to estimate net survival according to SES using the European Deprivation Index as a proxy and other major covariates (gender, initial clinical phase and years of disease onset).

Methods: In order to answer to our main objective, we will use a retrospective cohort of MS patients with a medical follow-up in one of the 18 centers included in SURVIMUS II, with a MS onset between 1960 and 2015 and with an informed vital at the date of December 31st, 2015.

The ecological score of deprivation EDI will be used as a proxy of the socioeconomic status and will be attributed from the geolocalisation to patient's residence address. Net survival is directly associated to the notion of "mortality in excess". This mortality will be estimated comparing the observed mortality in MS patients to mortality in the general population. The advantage of this methodological approach is that cause of death is not needed.

Statistical analysis: The influence of socioeconomic status on the excess of mortality will be estimated thanks to a parametric multivariate model of excess rate mortality. This model will be adjusted on other major covariates (gender, age at disease onset, and initial clinical phase) and will include potential complex effects as non-linearity, non-proportionality and interactions.

Expected results: We expect to highlight some differences of net survival in MS patients according to socioeconomic group as it was already shown in cancers. This study will complete information on factors of mortality excess in MS and knowledge on socioeconomic inequalities encountered all along MS disease course.


Eligibility Criteria:
Inclusion Criteria:

* all patients registered in 17 selected French OFSEP centres with core dataset with a sufficient level of data
* Diagnosis a of definite or probably MS according to Poser or McDonald criteria. With an MS onset date between January 1st, 1960 and December 31st, 2015.
* With a postal residence address well informed in the OFSEP database.

Exclusion Criteria:

* MS patients with less than one year's disease duration by the study end will be excluded.
Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx

The purpose of this study is to use intra-treatment 18FDG-PET/CT during definitive radiation therapy for human papillomavirus (HPV)-related oropharyngeal cancer (OPC) as an imaging biomarker to identify and select patients with a favorable response for chemoradiation dose de-escalation. This study will prospectively evaluate the clinical outcomes for patients undergoing dose de-escalation.


Eligibility Criteria:
Inclusion Criteria:

* Histologic documentation of squamous cell carcinoma of the oropharynx with p16-positive immunohistochemical staining and/or positive HPV in situ hybridization (ISH) and/or positive HPV PCR
* Stage I-III (AJCC 8th edition) with plan for concurrent chemotherapy per standard of care treatment
* Zubrod/ECOG score of 0-1
* Weight loss \<10% in the 3 months prior to diagnosis
* ≥ 18 years of age
* No prior chemotherapy for their current cancer diagnosis

Exclusion Criteria:

* Prior radiotherapy to the head and neck
* Medical contraindications to radiation therapy
* Absence of gross disease on imaging prior to beginning radiation therapy
* Distant metastatic disease
* Medical contraindication to PET/CT
* History of active cancer other than non-melanoma skin cancer within the last 5 years
Normal Variation of T1 Values With Cardiac Magnetic Resonance in Healthy Individuals

The purpose of the study is to determine the normal variation of T1 values with cardiac magnetic resonance in healthy individuals with respect to reproducibility, changes over time, and dependency on hydration status.

T1 mapping with cardiac magnetic resonance (CMR) is a novel non-invasive technique to quantitatively characterize the myocardium. T1 mapping is a surrogate marker of myocardial edema and fibrosis, and has the potential to be implemented in the diagnosis and follow-up of various cardiac diseases. However, there is limited data on the natural variation of T1 mapping in healthy individuals.

The study comprises three substudies:

1. Reproducibility: Two identical CMR examinations with T1 mapping will be performed on the same day .
2. Hydration changes: Participants will receive two liters of isotonic saline intravenously between two identical CMR with T1 mapping and echocardiographic examinations. The post-fluid order of CMR and echocardiography will be randomized.
3. Time changes: Participants will undergo CMR with T1 mapping at baseline, at 6-months follow-up, and at 1-year follow-up.

Eligibility Criteria:
Inclusion Criteria:

* Age 18-89 years
* Healthy

Exclusion Criteria:

* Chronic disease (e.g. cardiovascular disease, rheumatological disease, lung disease)
* Medications affecting the cardiovascular system (e.g. antihypertensives, statins, anticoagulants)
* Contraindications for CMR (claustrophobia, pregnancy, magnetic metallic implants)
Phenylalanine Requirement of Adults >65 Years.

Currently there are insufficient published studies on amino acid requirements in the elderly. Phenylalanine is one of the indispensable amino acids. Low levels of phenylalanine has been observed in in the blood of older adults. It is due the increased uptake by the liver and intestine. This decreased levels of phenylalanine could lead to decreased skeletal muscle protein synthesis. Requirement for elderly individuals have been set based on studies conducted in younger adults hence may be inaccurate. The goal of this study is to directly measure the phenylalanine requirement of male and female elderly subjects over 65 years using the direct amino acid oxidation (DAAO) technique.

1. To determine and compare the phenylalanine requirement of healthy elderly male and female adults over the age of 65 years using the DAAO technique (by measuring the oxidation of L-\[1-13 C\] phenylalanine to 13 CO 2 \[F 13 CO 2\] ) in response to graded intakes of phenylalanine.
2. To compare the requirement so derived to that of young healthy adult previously determined in our lab.

Eligibility Criteria:
Inclusion Criteria:

1. Healthy elderly males and females \> 65 years
2. Willingness to participate in the study and completed the screening procedures (height, weight, fasting blood sample and medical history questionnaire).
3. No recent history of weight loss
4. Absence of chronic disease or acute illness that could affect protein and AA metabolism (diabetes, cancer, liver or kidney disease, HIV, acute cold or flu, hypo or hyperthyroidism, rheumatoid arthritis treated with anti-inflammatory medications.
5. Non-smoking
6. Willingness to consume the diet provided

Exclusion Criteria:

1. Presence of disease known to affect protein and AA metabolism (diabetes, cancer, liver or kidney disease, HIV, acute cold or flu, hypo or hyperthyroidism, rheumatoid arthritis treated with anti-inflammatory medications).
2. On medications known to affect protein and amino acid metabolism (steroids).
3. Recent significant weight loss.
4. Individual on weight reducing diets.
5. Inability to tolerate the diet
6. Unwilling to have blood drawn from a venous access, or using a ventilated hood indirect calorimeter for the purposes of the study.
7. Significant coffee consumption of more than 2 cups/day
8. Significant alcohol consumption of more than one drink/day
Boswellia Serrata Extract in Acute Diarrhea

Acute diarrhea is a frequent problem worldwide, mostly due to gastrointestinal infections or food poisoning. Boswellia serrata could be active in the treatment of acute diarrhea due to its an-ti-inflammatory, antispasmodic and antimicrobial activity.


Eligibility Criteria:
Inclusion Criteria:

* presence of acute diarrhea of mild to moderate severity

Exclusion Criteria:

* patients with long term diarrhea
* iatrogenic diarrhea
* symptoms of functional gut disease or severe inter-current diseases
* severe diarrhea and dehydration requiring hospitalization and intravenous treatment
* subjects with high temperature (\> 38.5° C)
* subjects treated by other anti-diarrheal and antibiotic drugs in the last 24 hours
* severely malnourished subjects
* pregnant women
Effects of High-intensity Exercise With Hypoxia and Taurine Supplementation on Metabolic and Mitochondrial Parameters

The prevalence of obesity in Brazil is one of the highest in Latin America. As an inflammatory disease, obesity needs to be treated, and one of the best interventions is exercise. This research aims to learn more about the effects of combining high-intensity training, recovery hypoxia, and taurine supplementation. To better understand these effects, the researchers will compare hypoxia and normoxia, as well as taurine and placebo, with all participants training in the same way. The researchers will also investigate mitochondrial respiration and food consumption to connect certain aspects of obesity with overall health.

Obesity is characterized by a chronic inflammatory state, often linked with elevated oxidative stress and mitochondrial dysfunction. While physical exercise can trigger inflammatory responses due to muscle damage, it also promotes significant bodily adaptations, particularly in body composition, physical fitness, and skeletal muscle tissue, including enhanced mitochondrial dynamics. Moderate hypoxia, when combined with exercise, further amplifies these benefits by increasing the expression of genes related to mitochondrial biogenesis, GLUT1 expression, and angiogenesis. Previous findings suggest that high-intensity physical activity not only improves cardiorespiratory capacity and alters body composition but also significantly elevates inflammation. Consequently, taurine, a supplement known for its anti-inflammatory properties and ability to reduce oxidative stress, should be considered to mitigate these issues and optimize the benefits of exercise and hypoxia. Based on these premises, it is hypothesized that the combination of taurine supplementation with physical training under recovery hypoxia may reduce the significant rise in pro-inflammatory cytokines, thereby enhancing the potential benefits of exercise and moderate hypoxia.

Eligibility Criteria:
Inclusion Criteria:

* Women
* Age between 25 - 45 years old;
* BMI between 30 - 35kg/m²;
* Not be on a diet;
* Not be on a physical activity program;
* Not be menopaused.

Exclusion Criteria:

* Smokers;
* Alcoholics;
* Use thyroid medication;
* Carry out nutritional monitoring or in treatment for weight loss;
* Hypertension;
* Metabolical syndrome;
* Have any comorbidity associated to obesity;
* Drugs use.
Dermacyd Breeze (Lactic Acid) Pocket BR - Photo Evaluation

To demonstrate the absence of photoirritation and photosensitization potential of the product Dermacyd Breeze (Lactic Acid) Pocket BR.


Eligibility Criteria:
Inclusion criteria:

* Age between 18 and 60 years old;
* Phototype Skin II and III;
* Integral skin test in the region;
* Willingness in following the study procedures and to be present in the clinic at the days and scheduled time for medical evaluations and for application of occlusion;

Exclusion criteria:

* Lactation or gestation;
* Use of Antiinflammatory and/or immunosuppression drugs 15 days before the selection;
* Diseases which can cause immunity decrease, such as HIV, diabetes;
* Use of drug photosensitizer;
* History of sensitivity or irritation for topic products;
* Active cutaneous disease which can change the study results;
* History of photodermatosis active;
* Family or personal antecedent of cutaneous photoinduced neoplasias;
* Presence of a precursor lesion of cutaneous neoplasia, such as nevus melanocyte and queratoses actinium;
* Intense solar exposure in the study area;
* Use of new drugs or cosmetics during the study

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Liquid Biomarker Study in Melanoma and Non-Melanoma Skin Cancers

The goal of this observational study is to study blood samples and compare them to other biospecimens and clinical outcomes in participants who have melanoma or non-melanoma skin cancers. The main question it aims to answer is:

* Are blood based signatures able to predict progression-free survival (PFS)?

Participants undergoing regular treatment for their skin cancer will provide blood samples.

This observational study is being done to identify possible biomarkers that can be used for prognostic, prediction, or monitoring considerations in patients with melanoma or non-melanoma skin cancer undergoing treatment. Investigators plan to investigate blood factors which include circulating tumor cells (CTCs - i.e., cancer cells that can be detected in the blood) and their associated protein and mRNA expression; circulating tumor DNA (ctDNA - i.e., pieces of DNA from cancer cells that can be found in the blood); and tumor-derived exosomes (i.e., extracellular vesicles generated by cancer cells that carry nucleic acids, proteins, and metabolites).

Eligibility Criteria:
Inclusion Criteria:

* Age ≥18 years.
* Participants must meet at least one of the following criteria:
* Finding suspicious of melanoma or non-melanoma skin cancer based on clinical, radiographic, or laboratory findings. Non-melanoma skin cancers include: basal cell carcinoma, cutaneous squamous cell carcinoma, and Merkel cell carcinoma.
* A confirmed diagnosis of melanoma or non-melanoma skin cancer.

Exclusion Criteria:

* Vulnerable populations, including pregnant women, those who lack consent capacity, the mentally ill, prisoners, cognitively impaired persons, children (age \&amp;lt;18), and UW employees that report to the investigator(s) or to study team members.
* Not suitable for study participation due to other reasons at the discretion of the investigators.
An Coach-based Intervention Study of an Extended Discharge Planning Program on Patients With COPD

The purpose of this 4-year study is to investigate the relationship between cognition and learning ability on patients with COPD during hospitalization to establish and evaluate the effects of the community-extended discharge planning program. The transition theory is used as the theoretical base in this study. The patients with diagnosis of COPD in hospital will be invited to participate. The data of demographic variables, the cognitive function¸ the respiratory function, the effect of learning and the usage of medical resources after discharged will be collected. In the first year, we will establish the protocol of respiratory teaching in two modes, and to compare the differences among computer interaction game intervention, face to face teaching and routine nursing intervention, also to evaluate the related factors and the effect of learning on patients with COPD for determining the needs of patients' learning mode and the optimal frequency of nursing teaching mode during hospitalization in the second year. For the second year, build upon the results of the first year, the preliminary draft of the community-extended discharge planning program that base on the experts' meeting and the interview with the patients. Also, a pilot study that revising the content and testing the feasibility of respiratory teaching protocol will be conducted. For the 3rd and 4th year, using case-control RCT design, the community-extended discharge planning program will be tested in patients during their hospital stay and post-discharge period. The effects of this community-extended discharge planning program will be evaluated on outcome variables of patients' cognitive learning function, utilization of health care resources. The results of this study will help to develop a community-extended discharge planning for patients with COPD on cognition level and learning ability. Furthermore, the protocol of the community-extended discharge planning will serve as references to prolong the development of disease deterioration, reduce the probability of readmission and improve the quality of life.

1. To establish the protocol of resiratory teaching mode.
2. To evaluate the related factors and the effect of learning on patients with COPD.
3. A modified discharge plan with respiratory teaching will implement to COPD patients.

Eligibility Criteria:
Inclusion Criteria:

* Being COPD Diagnosed Inpatients

Exclusion Criteria:

* Cancer with active treatment plan
* Lost speak ability
* Psychiatric problem
* Active TB
Negative Pressure Wound Therapy to Reduce Surgical Site Infection

The purpose of this study is to compare the rate of surgical site infection between traditional wound care and negative pressure wound therapy. Wounds will be assessed 4-5 days after surgery and at the first clinic visit after surgery.


Eligibility Criteria:
Inclusion Criteria:

* Female and male patients 18 years of age or older
* Scheduled for an elective surgery in either open CRS or open HPBS. This includes, but is not limited to: ileocecectomy, right hemicolectomy, extended right hemicolectomy, transverse colectomy, left hemicolectomy, sigmoidectomy, proctectomy, low anterior resection, or abdominoperineal resection gastrectomy, hepatectomy, bile duct reconstruction, duodenectomy, pancreatectomy, pancreaticoduodenectomy, or pancreatic duct reconstruction

Exclusion Criteria:

* The need for emergency surgery.
* The need for use of only laparoscopic surgery.
* Presence of bowel obstruction, strangulation, peritonitis or perforation.
* The presence of local or systemic infection preoperatively.
* ASA class ≥4.
* Inability to provide informed consent and authorization.
* Known allergy or hypersensitivity to silver.
* Any clinically significant condition that, in the investigator's opinion, would significantly impair the subject's ability to comply with the study.
Effectiveness of Kinesio Tapping for the Treatment of Patients With Acute Low Back Pain: A Randomized Control Trial

The objective of the study was to determine the effectiveness of Kinesio Taping (KT) for the treatment of patients with acute low back pain.

In this study a total of 56 patients with acute low back pain were randomly allocated to the experimental group, KT along with conventional Physical therapy (PT), or the control group, conventional PT alone.

The objective of the study was to determine the effectiveness of Kinesio Taping (KT) for the treatment of patients with acute low back pain.

In this study a total of 56 patients with acute low back pain were randomly allocated to the experimental group, KT along with conventional Physical therapy (PT), or the control group, conventional PT alone. 28 Patients received KT in addition to conventional PT while 28 patients received conventional PT alone for two weeks. Oswestry disability index (ODI) and numeric pain rating scale (NPRS) were used for the measurement of outcomes.

Eligibility Criteria:
Inclusion Criteria:

* Both Genders
* Age between 18 and 60 years
* History of LBP less than

Exclusion Criteria:

* Patients having diagnosed conditions of spondylolisthesis, spondylosis, lumbar stenosis, spinal tumor, lumber fracture, renal disease and trauma were excluded from the study.
* Patients either with chronic LBP (duration more than 3 months) or contraindicated to KT (skin allergy or pre-existing skin lesion or infection) were also excluded.
* Female Pregnant patients were also excluded from the study.
Swedish Adjustable Gastric Banding Observational Cohort Study

Longitudinal prospective cohort study of patients treated consecutively by SAGB in a sample of centers representative of this activity in France.

Verification by means of a screening log (exhaustive list of all bariatric procedures performed by participating surgeons between the beginning and end of the cohort inclusion period) requested from all centers.

No comparator group. No randomization or blinding techniques

Longitudinal prospective cohort study of patients treated consecutively by SAGB in a sample of centers representative of this activity in France.

The study is originated in collaboration with HAS in France and has a target of 500 patients treated with gastric banding because of morbid obesity.

Eligibility Criteria:
Inclusion Criteria:

* morbidly obese patients (BMI\>35 with comorbidities or BMI\>40 without comorbidities) in France selected for gastric banding based on standard local clinical practice

Exclusion Criteria:

* lower BMI, contraindications based on local clinical assessment
Pilot Study of Enalapril and Renal Function in Patients With IgA Nephropathy

OBJECTIVES: I. Determine the most sensitive outcome measures (functional or morphological) of a progressive renal injury in patients with IgA nephropathy.

II. Determine which of these patients are destined to progress to further injury in order to target them for therapy.

III. Elucidate the determinants of progression in those patients who exhibit evidence of either increasing impairment of ultrafiltration capacity or ongoing destruction of nephrons.

PROTOCOL OUTLINE: Patients receive oral enalapril daily. Treatment continues for 5 years in the absence of unacceptable toxicity.

Patients undergo renal function studies every 6-12 months for 5 years. Patients undergo renal biopsy at 36-48 months after study entry.

Eligibility Criteria:
Histologically confirmed IgA nephropathy, diagnosed within the past 3 years

Clinical presentation of either isolated hematuria/proteinuria for less than 3 years OR

Acute nephritic or nephrotic syndrome

No secondary forms of IgA nephropathy associated with chronic inflammatory disease of the bowel and liver

No end stage renal failure as defined by the following: Glomerular filtration rate less than 15 mL/min AND Extensive glomerulosclerosis and tubulointerstitial damage

No systemic lupus erythematosus or systemic (extrarenal) vasculitis (Henoch-Schonlein syndrome)

Healthy volunteers will be accrued as a control group

No other concurrent medical or psychiatric illness that would preclude study