cyrilzakka/clinical-trials huggingface dataset:
Effects of Osteopathic Manipulative Treatment Associated With Pain Education and Clinical Hypnosis

INTRODUCTION: Chronic low back pain (CLBD) is one of the major public health problems in the world. Given the complexity of the situation, complementary and alternative practices such as pain neuroscience education (PNE), clinical hypnosis (HC) and osteopathic manipulative treatment (OMT) are options for we manage these patients. OBJECTIVE: The aim of this study will be to evaluate the effects of OMT associated with PNE through HC on pain and disability in patients with CLBP compared to PNE and HC. MATERIALS AND METHODS: The study design will be a randomized clinical trial and 40 adults diagnosed with chronic low back pain will be recruited. Subjects will be randomized in two groups: the first group (G1) will be submitted to the PNE based on information from the book "Explain Pain" with hypnotic suggestions. Group 2 (G2) will receive PNE following the book "Explain Pain" with hypnotic suggestions associated with OMT. Volunteers will be evaluated by a blind researcher the interventions performed in the allocation of groups. The evaluation moments will be pre-intervention and immediately after the end of the last intervention for G1 and G2. Volunteers continued to be evaluated 4 weeks after completion of the protocols. Pain will be evaluated as the main outcome, being evaluated by the numerical pain scale. Pain will also be assessed by the pressure threshold using a pressure algometer device (Fnd-50, PIAB 50-n, Italy) in the lumbar region. Still as the main outcome, disability will be assessed using the Oswestry Disability Questionnaire. As secondary outcomes, the patient's global impression of improvement, central sensitization, biopsychosocial factors will be evaluated. The patient's global impression of improvement will be assessed using the Percentage of Improvement Scale with a score of -5 to +5; the Central Sensitization will be assessed using the Central Sensitization Questionnaire and the biopsychosocial factors using the Start Beck Toll questionnaire. In addition, the behavior of the autonomic nervous system will be evaluated through the Heart Rate Variability (HRV), which will be analyzed through linear methods, in the domains of time and frequency, and by geometric indices. The researcher/evaluator will be blinded to the allocation of intervention groups. Given the nature of the study, it is impossible to blind the researcher/therapist and volunteers.


Eligibility Criteria:
Inclusion Criteria:

* Nonspecific Low Back Pain for at least 3 months
* Score on the numerical pain scale of at least 3 points

Exclusion Criteria:

* Data from participants with less than 95% of sinus beats
* Participants that present increased symptoms in any stages of the study
* Patients who are undergoing concomitant physical therapy treatment, patients with contraindications to exercise, smokers/alcoholics, severe vertebral or neural pathologies, previous spine surgeries, cardiorespiratory disease, LBP as a secondary complaint, pregnancy, hearing problems, or illiteracy patients, not will are able to participate the protocol.
Self-management Intervention for Children With Chronic Medical Complexity: Pilot Feasibility Trial

The investigators have developed a tool to facilitate self-management for children with medical complexity (complex, multisystem chronic diseases) called MyChildCMC (My Child's Complex Medical Condition). MyChildCMC is an online, phone application (app) that engages parents daily in ongoing monitoring of common, crosscutting acute symptoms, including respiratory distress, inadequate feeding/fluid intake, fever, altered mental status, pain, and seizure status. The MyChildCMC app also guides parents to recognize early warning signs for health deteriorations to avoid acute events (i.e., ED visits and/or hospitalizations).

Parent comments during the development of the MyChildCMC application revealed that the tool had potential in helping them manage their child's chronic conditions. This study will be the first to explore if online home monitoring using online technology is feasible, scalable, and can lead to improved CMC outcomes. This pilot trial for the MyChildCMC app was designed to determine preliminary impact by comparing outcomes (child QOL, child emergency department and hospital admissions, and parent/caregiver satisfaction with care) between the intervention and control groups. If successful, our approach will be a model for improving CMC care and reducing costs for families and children with medical complexity. Future MyChildCMC trials will integrate care coordination and a more robust alert system to help facilitate care and follow-up for patients.

Aim: Investigators will assess the impact of the MyChildCMC app by comparing the following outcomes for the child and caregiver:

1. Child Quality of Life (QOL)
2. Child Emergency Department (ED) and hospital admissions
3. Number of hospital days
4. Parent/Caregiver satisfaction with care

Eligibility Criteria:
Participant Inclusion Criteria:

Children with complex medical conditions\* ages 1 through 20 years with their primary caregiver (primary person caring for the child) who:

* have been seen at Primary Children's Hospital within 365 days,
* own a smartphone or a tablet computer with Internet access, and
* are English speaking \*Physician diagnosis was used to determine CMC diagnosis

Exclusion Criteria:

* Critically ill children in imminent death
* Non-English speakers
Proprioception in the Improvement of Sports Performance in Long Jumpers.

Introduction: In jumping sports the tendinopathies of patellar and Achilles tendon are very frequent. Sports performance is the action that optimizes the relationship between physical abilities and the exercise to be performed. Good proprioceptive work favors the correct execution of the technique in jumping sports.

Aim: To evaluate the effectiveness of the lower limb proprioception exercise in the increase of sports performance, in adults and federated long jumpers Study design: Randomized single-blind multicenter study, with follow-up period. Methods: The 139 subjects included in the study will be randomly assigned to the two study groups: experimental (proprioception protocol) and control (non-intervention group). The intervention will be carried out for 4 weeks, with two weekly sessions, lasting 25 minutes. Three evaluations were carried out (baseline, post-intervention and follow-up). The study variables will be: Proprioception (evaluated by the Romberg test and the SEBT), and sports performance (evaluated with vertical, horizontal jump and competition simulation tests). The analysis of normality will be carried out by the Kolmogorov Smirnof test and in the case of homogeneity of the groups, through the t-student test of related measures and an ANOVA of repeated means, we will calculate the difference between the different evaluations and the effect intra and intersubject.

Expected results. To observe improvement in sports performance, once the proprioceptive exercises have been carried out.


Eligibility Criteria:
Inclusion Criteria:

* Jumping athletes in length
* Female
* With an age range of 18 to 35 years
* Currently participate in regional and / or national competitions.

Exclusion Criteria:

* Not signed the informed consent document
* Practice another sport discipline
* Have some type of medical diagnosis of injury to the lower limb at the time of study.
Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms

Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder in adults and the treatment of choice is by particle repositioning manoeuvres (PRM). This study aims to compare the treatment efficacy of two home-based exercises, self-Epley manoeuvre (SEM) and Brandt-Daroff exercise (BDE) in patients with posterior canal BPPV based on vertigo resolution, reduction of vertigo intensity, the Dizziness Handicap Inventory scores and the conversion of a positive to negative Dix-Hallpike test.

Study Objective:

To compare the efficacy of the self-Epley manoeuvre to the Brandt-Daroff exercise in resolving vertigo symptoms in patients with unilateral posterior canal BPPV.

Study Design:

Single-blind randomized controlled study

Sample Size:

Fifty patients were recruited in the study and were divided with 25 patients in each treatment arm.

Study Method:

Patients who satisfy the inclusion criteria and have given informed consent were randomized into the 2 treatment groups. A dedicated physiotherapist will demonstrate the selected exercise (either SEM or BDE) and observed the patient performing the exercise twice to ensure the ability of the patient to perform it correctly at home. A diary was provided for the patients to chart the therapy sessions performed at home as well as a pamphlet with simple illustrated instructions of the chosen exercise. The patients were asked to perform the home-based exercise for 2 weeks.

Primary Outcome Measure

- Resolution of vertigo symptoms in patients with unilateral posterior canal BPPV.

Secondary Outcome Measures

* Vertigo resolution at 1 and 6 months;
* The conversion of positive to negative Dix-Hallpike test between both groups after 1 month;
* Vertigo intensity in unresolved vertigo patients at 1 \& 6 months;
* The Dizziness Handicap Inventory between both groups at 1 and 6 months.

Eligibility Criteria:
Inclusion Criteria:

* patients who have had symptoms of vertigo for at least 1 week duration,
* patients with a documented positive Dix-Hallpike test on referral,
* patients with intact cognitive function and had the ability to communicate and understand instructions to perform a home-based exercise.

Exclusion Criteria:

* patients with history of prior ear surgery,
* patients with orthopaedic or connective tissue disorder that impairs functional neck or trunk range of motion,
* patients with a significant neurological disorder or spinal cord damage, and
* patients who have been prescribed with home-based exercises for BPPV.
Hepatitis B Research Network Pediatric Cohort Study (HBRN)

The purpose of this study is to describe participants 6 months to \<18 years of age with hepatitis B virus (HBV) infection in a prospective cohort in the United States (US) and Canada and identify predictors of disease activation and progression.

•Primary Aim:

o To describe participants 6 months to \<18 years of age with hepatitis B virus (HBV) infection in a prospective cohort in the United States (US) and Canada and identify predictors of disease activation and progression

Secondary Aims:

* To describe clinical, virological, and immunological characteristics of participants with HBV in the US and Canada.
* To evaluate changes in HBV infection status and hepatitis B surface antigen (HBsAg) levels and factors associated with those changes.
* To verify whether a baseline HBsAg below 1,000 IU/mL and HBV DNA below 1,000 IU/mL is an accurate predictor of people who are, or who will become, inactive carriers, defined as people who are HBsAg positive, hepatitis B "e" antigen (HBeAg) negative, have normal alanine aminotransferase (ALT) and HBV DNA under 1,000 IU/mL on at least two occasions over a period of at least 6 months with HBV DNA under 1,000 IU/mL.
* To assess the health related quality of life (HRQOL) of treatment naïve hepatitis B surface antigen (HBsAg) positive children and adolescents
* To develop a bank of biospecimens (e.g., serum, plasma, DNA, liver tissue) obtained from participants with HBV infection.
* To identify pediatric participants from 2 years to \<18 years of age with chronic HBV infection for potential participation in treatment study to be conducted by the Hepatitis B Research Network (HBRN).

Eligibility Criteria:
Inclusion Criteria:

* Written informed consent/assent as appropriate
* At least 6 months to \<18 years of age
* Hepatitis B surface antigen (HBsAg) positive

Exclusion Criteria:

* Hepatic decompensation
* Hepatocellular carcinoma (HCC)
* Liver transplantation
* Current Hepatitis B antiviral treatment (except pregnant females)
* Known coinfection with HIV (patients with hepatitis D or hepatitis C coinfection are not excluded)
* Medical or social condition which in the opinion of the principal investigator would interfere with or prevent regular follow up.
* Unable or unwilling to return for regular follow-up
Cancer Genome Analysis

Next generation sequencing (including targeted gene seqeuncing, exome and transcriptome sequencing) will be performed from fresh frozen tumor samples to understand the genetic alteration of tumors and to aid in optimal selection of further therapeutic agents.


Eligibility Criteria:
Inclusion Criteria:

* patients with malignant tumor
* receiving or planning to receive chemotherapy
* with fresh frozen tumor tissue
* with informed consent
Oncology Research Information Exchange Network (ORIEN) Lung Cancer Study

The Moffitt Cancer Center and PatientsLikeMe.com (PLM), an online patient community, are working together to better understand the patient's entire lung cancer experience, both inside and outside the doctor's office. By combining the data that is captured by their care team in the clinic with the data participants enter at their home on PatientsLikeMe.com, the investigators hope to improve patient-physician treatment decisions, so that the patient's personal treatment goals and quality of life have the highest chances of being fulfilled.

The aim of the study is to assess the real-world patient experience by evaluating the patients' quality of life, treatment toxicities, and clinical measures over a 6-month period. The ultimate goal of this research is to improve patient-physician treatment decisions, so that the patient's personal treatment goals and quality of life have the highest chances of being fulfilled.

Aim 1. To track the toxicities/side-effects of FDA approved molecular targeted agents, immunotherapies, and combinations of treatments for NSCLC in a clinical setting for six months.

Aim 2. To assess the impact of these treatment regimens on patient toxicities, symptoms, function, and quality of life, after adjustment for clinical factors and patient characteristics during the 6 month follow-up period.

Eligibility Criteria:
Inclusion Criteria:

* \>= 18 years of age
* Diagnosed with metastatic (stage 3b/4) non-small cell lung cancer (NSCLC)
* The total combined sample size must include at least 100 people who received one or more treatments of PD-1/PDL-1 inhibitor treatment (immunotherapy), and 50 patients who received an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI). Patients receiving any other treatments will be tracked for treatment outcomes, as well as to serve as comparison participants during data analyses of outcomes associated with PD-1/PDL-1 or EGFR-TKI).
* Consented separately to the Total Cancer Care (TCC) protocol
* Have access to the internet
* Willing to enroll in the free online health tracking and patient community "PatientsLikeMe"

Exclusion Criteria:

* Patients enrolled in Phase I clinical trial protocols
* Patients enrolled in Phase II, III or IV clinical trials involving blinded therapies (patients in open label trials will be eligible)
Effect of Different Duration of Dry Needling on Muscles Strength of Flexor Forearm Muscles of Dominant Hand in Healthy Subjects

Dry needling is typically used to treat muscles, ligaments, tendons, subcutaneous fascia, scar tissue, peripheral nerves, and neurovascular bundles for the management of a variety of neuromusculoskeletal pain syndromes.However, there are contradictory research articles about the optimal duration of dry needling per session.

Dry needling is 'an invasive technique used by physical therapists to treat myofascial pain that uses a dry needle, without medication or injection, which is inserted into areas of the muscle known as trigger point defines dry needling as including both muscular and connective tissues, but not neural stimulation. The paper reads, 'dry needling is a skilled intervention that uses a thin filiform needle to penetrate the skin and stimulate underlying myofascial trigger points, muscular, and connective tissues for the management of neuromusculoskeletal pain and movement impairments.

The dry needling is reported to improve the level of pain, muscle strength, and flexibility. However, the optimal duration of dry needling to improve muscle strength is still Unknown.

Eligibility Criteria:
Inclusion Criteria:

Patient with osteoarthritis

Exclusion Criteria:

Patient with musculoskeletal disorders Metabolic disorders causing knee pain Surgery
Exercise for Oncology Care Professionals

The goal of this preference-based pilot study will be to assess the feasibility and acceptability, and impact of a 12-week exercise intervention on oncology care provider burnout. Participants self-select to participate into one of two exercise groups. Group assignment will be based on participant preference.

Group 1: Supervised circuit-based resistance exercise

Group 2: Nature-based walking


Eligibility Criteria:
Inclusion Criteria:

* 18 years of age or older;
* Able to speak/write in English;
* Must be providing formal care to cancer patients in a clinical setting within the Halifax Municipality;
* Actively practicing within the Nova Scotia Cancer Care Program; and
* Able and willing to engage in low-to-moderate intensity physical activity.

Exclusion Criteria:

* Exceeding Canadian physical activity guidelines of 150-minutes of moderate-to-vigorous physical activity per week; and
* Any health condition that would preclude safe participation in a new exercise program.
Seminal Level of Clusterin Before Testicular Sperm Extraction

Measurement of clusterin level in the semen of infertile males undergoing testicular sperm extraction.

Clusterin, known as apolipoprotein J, sulphated glycoprotein-2 or testosterone - repressed prostate message-2.

It plays important roles in several pathophysiological processes, including tissue remodelling, lipid transport, reproduction, complement regulation and apoptotic cell death .

As clusterin expression is markedly upregulated in various normal and malignant tissues undergoing apoptosis, it has been regarded as a marker for cell death.

There is a conflicting findings concerning the relationship between elevated clusterin expression and enhanced induction of apoptosis; that is, clusterin has appeared to have a powerful anti-apoptotic function through a chaperone-like activity.

In addition to the anti-apoptotic activity, seminal clusterin was reported to promote a tolerogenic response to male antigens, thereby contributing to female tolerance to seminal antigens.

In the testis, clusterin is secreted by Sertoli cells into the fluid of the seminiferous epithelium and deposited onto the membranes of elongating spermatids and mature spermatozoa.

To date, however, there has been little information with respect to the functional roles of clusterin in the male reproductive tract under physiological conditions.

In particular, it remains controversial as to whether or not clusterin helps assist the normal spermatogenesis.

Nonobstructive azoospermia (NOA) males are characterised by impaired spermatogenesis.

Although NOA patients have impaired global spermatogenic function, focal areas of spermatogenesis may still exist in their testes.

Focal spermatogenesis could possibly be obtained by testicular sperm extraction (TESE) technique .

A number of factors have been suggested to be of predictive value for patients with a good chance to retrieve sperm cell such as testicular volume, serum FSH levels , serum total testosterone and serum inhibin B levels.

Eligibility Criteria:
Inclusion Criteria:

* Infertile males , Azoospermia undergoing TESE as a preliminary step for ICSI .
* Age: 20-50 year

Exclusion Criteria:

* males \<20 years and \>50years
* Cryptorchidism .
* Testicular Agenesis and testicular atrophy .
Use of ROTEM Intraoperatively in Women With Placenta Accreta

This study evaluates the use of rapid tests for hematocrit and clotting function in women undergoing surgery for placenta accreta. Half of participants will have these rapid tests performed during surgery to guide blood product transfusion and the other half will have standard lab tests performed to guide transfusion.

Placenta accreta has become an increasingly common pregnancy complication. Serious complications are common in patients with placenta accreta, including hemorrhage, transfusion of blood products, abdominal organ injury, bladder surgery, and ICU admission. Hemorrhage, or excessive blood loss, is the most common complication and often results in impaired ability for the body to form blood clots normally.

The development of rapid testing of hematocrit and clotting function may allow for earlier identification of patients who have severe blood loss and development of clotting abnormalities. The investigators are testing whether use of this technology in patients undergoing surgery for placenta accreta, with earlier identification of patients with severe blood loss or clotting abnormality, will result in a lower need for transfusion and fewer complications.

Eligibility Criteria:
Inclusion Criteria:

* Women diagnosed with placenta accreta during pregnancy who are scheduled to have delivery by cesarean section with hysterectomy to follow.

Exclusion Criteria:

* Non-English speaking
Safety and Efficacy of Mobic® Ampoules in the Initiation of Treatment of Painful Exacerbations of Osteoarthritis, Rheumatoid Arthritis and Other Similar Painful Inflammatory Conditions

Study to determine the safety and efficacy of Mobic® ampoules in the initiation of treatment of painful exacerbations of osteoarthritis, rheumatoid arthritis and other similar painful inflammatory conditions.


Eligibility Criteria:
Inclusion Criteria:

* Painful acute exacerbations of inflammatory rheumatism (rheumatoid arthritis and ankylosing spondylitis), painful acute exacerbations of osteoarthritis and other similar conditions requiring acute treatment with an anti-inflammatory drug

Exclusion Criteria:

* none